The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development

EMBO Journal

Volumn 21, Issue 13, 2002, Pages 3464-3475

  Ito, Mitsuhiro ^a   Okano, Hirotaka J ^a   Darnell, Robert B ^a   Roeder, Robert G ^a  

^a Laboratory of Biochemistry   (United States)

Author keywords

Embryonic lethality; Mediator; RNA polymerase II; TRAP; TRAP100 TRAP95 SUR2 submodule; TRAP220

Indexed keywords

E1A PROTEIN; ONCOPROTEIN; PROTEIN TRAP100; PROTEIN TRAP95; RECEPTOR PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONGENITAL MALFORMATION; EMBRYO; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; YEAST;

ABNORMALITIES, MULTIPLE; ADENOVIRUS E1A PROTEINS; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, LETHAL; GENES, REPORTER; HERPES SIMPLEX VIRUS PROTEIN VMW65; MACROMOLECULAR SUBSTANCES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CALCITRIOL; RNA POLYMERASE II; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0036645671     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf348     Document Type: Article

References (39)

1. TFIIH is negatively regulated by cdk8-containing Mediator complexes
2. IIs
3. Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a Mediator subunit
4. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
5. Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme
6. Structural organization of yeast and mammalian Mediator complexes
7. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
8. Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID
9. The coregulator exchange in transcriptional functions of nuclear receptors
10. A novel human SRB/MED-containing cofactor complex, SMCC. Involved in transcription regulation
11. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases
12. Dissecting the regulatory circuitry of a eukaryotic genome
13. The TRAP/SMCC/Mediator complex and thyroid hormone receptor function
14. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
15. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action
16. Mammalian Mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
17. A multiprotein Mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
18. An activator binding module of yeast RNA polymerase II holoenzyme
19. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
20. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs
21. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
22. RNA polymerase II holoenzymes and subcomplexes
23. Mediator of transcriptional regulation
24. Mediator protein mutations that selectively abolish activated transcription
25. Composite co-activator ARC mediates chromatin-directed transcriptional activation
26. 12bp polymorphism for schizophrenia and hypothyroidism
27. Mediator complexes and transcription
28. A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
29. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
30. Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids
31. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
32. Transcription control by E1A and MAP kinase pathway via Sur2 Mediator subunit
33. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
34. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
35. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice
36. Interaction of the Srb10 kinase with Sip4, a transcriptional activator of gluconeogenic genes in Saccharomyces cerevisiae
37. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
38. Identification of mouse TRAP100: A transcriptional coregulatory factor for thyroid hormone and vitamin D receptors
39. Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality