Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction

Molecular Cell

Volumn 10, Issue 2, 2002, Pages 409-415

  Davis, Joshua A ^a   Takagi, Yuichiro ^b   Kornberg, Roger D ^b   Asturias, Francisco J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOLOENZYME; PROTEIN; PROTEIN RPB11; PROTEIN RPB3; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; CORRELATION ANALYSIS; ELECTRON MICROSCOPY; ENZYME STRUCTURE; EUKARYOTE; PROKARYOTE; PROTEIN INTERACTION; TRANSCRIPTION REGULATION; YEAST;

EUKARYOTA; PROKARYOTA;

EID: 0036671095     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00598-1     Document Type: Article

References (31)

1. Conserved structures of mediator and RNA polymerase II holoenzyme
2. Transcription activation by catabolite activator protein (CAP)
3. Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF
4. Structure of yeast RNA polymerase II in solution: Implications for enzyme regulation and interaction with promoter DNA
5. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution
6. Structural organization of yeast and mammalian mediator complexes
7. A mediator required for activation of RNA polymerase II transcription in vitro
8. Spider and web: Processing and visualization of images in 3D electron microscopy and related fields
9. Structural basis of transcription: An RNA polymerase II elongation complex at 3.3 Å resolution
10. Improved methods for building protein models in electron density maps and the location of errors in these models
11. The structural and functional organization of the yeast mediator complex
12. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
13. An activator target in the RNA polymerase II holoenzyme
14. Requirement for a functional interaction between Mediator components Med6 and Srb4 in RNA polymerase II transcription
15. Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme
16. Mediator of transcriptional regulation
17. The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain
18. Mediator protein mutations that selectively abolish activated transcription
19. Transcription activation at class II CAP- dependent promoters: Two interactions between CAP and RNA polymerase
20. Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II
21. Mediator complexes and transcription
22. Three-dimensional reconstruction from a single-exposure random conical tilt series applied to the 50s ribosomal subunit of Escherichia coli
23. Reconstitution of transcription with five purified initiation factors and RNA polymerase II from Saccharomyces cerevisiae
24. The ultrastructure of macromolecular complexes studied with antibodies
25. RNA polymerase transcription factor IIH holoenzyme from yeast
26. Evidence for a mediator cycle at the initiation of transcription
27. Structure, function, and activator-induced conformations of the CRSP coactivator
28. Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria
29. Determination of the location of proteins L14, L17, L18, L19, L22, L23 on the surface of the 50S ribosomal subunit of Escherichia coli by immune electron microscopy
30. A transcription reinitiation intermediate that is stabilized by activator