TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4

Molecular and Cellular Biology

Volumn 22, Issue 15, 2002, Pages 5626-5637

  Malik, Sohail ^a   Wallberg, Annika E ^a   Kang, Yun Kyoung ^a   Roeder, Robert G ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 4; HISTONE ACETYLTRANSFERASE; PROTEIN P300; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2;

ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA TEMPLATE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN INTERACTION; TATA BOX; TRANSCRIPTION INITIATION;

ACETYLTRANSFERASES; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL EXTRACTS; CELL LINE; CELL NUCLEUS; CHROMATIN; DNA; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HELA CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HISTONE ACETYLTRANSFERASES; HUMANS; IMMEDIATE-EARLY PROTEINS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PHOSPHOPROTEINS; PROTEIN BINDING; REPRESSOR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0036318299     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.15.5626-5637.2002     Document Type: Article

References (53)

1. Promoter-dependent transcription by RNA polymerase II using immobilized enzyme complexes
2. Requirement of TRAP/Mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID TAFs
3. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
4. The many HATs of transcription coactivators
5. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
6. CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression
7. ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR in vitro
8. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
9. Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of TATA box-binding protein-associated factors
10. Activator-dependent transcription by mammalian RNA polymerase II: In vitro reconstitution with general transcription factors and cofactors
11. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes
12. Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4
13. A novel human SRB/MED-containing complex, SMCC, involved in transcription regulation
14. Functional domains of the nuclear receptor hepatocyte nuclear factor 4
15. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha
16. Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins
17. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
18. ACF consists of two subunits, Acf-1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly
19. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
20. The human general co-factors
21. ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
22. Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300
23. Transcription of eukaryotic protein-coding genes
24. An activator binding module of yeast RNA polymerase II holoenzyme
25. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
26. A dynamic model for PC4 coactivator function in RNA polymerase II transcription
27. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs
28. Transcriptional activation by the orphan nuclear receptor ARP-1
29. TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4
30. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
31. The RXR heterodimers and orphan receptors
32. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo
33. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
34. Mediator of transcriptional regulation
35. Composite co-activator ARC mediates chromatin-directed transcriptional activation
36. Transcriptional activation by recruitment
37. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
38. The role of general initiation factors in transcription by RNA polymerase II
39. Role of general and gene-specific cofactors in the regulation of eukaryotic transcription
40. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Spl
41. Orphan receptor HNF-4 and liver-specific gene expression
42. Liverenriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
43. Nuclear receptors in nematodes: Themes and variations
44. Acetylation regulates transcription factor activity at multiple levels
45. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
46. TAFs mediate transcriptional activation and promoter selectivity
47. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
48. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4
49. The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex
50. Coactivator and corepressor complexes in nuclear receptor function
51. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
52. A transcription reinitiation intermediate that is stabilized by activator