Mammalian Srb/mediator complex is targeted by adenovirus E1A protein

Nature

Volumn 399, Issue 6733, 1999, Pages 276-279

  Boyer, Thomas G ^a,d   Martin, Michelle E D ^a   Lees, Emma ^b   Ricciardi, Robert P ^c   Berk, Arnold J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ADENOVIRUS; ARTICLE; CAENORHABDITIS ELEGANS; CELL COMMUNICATION; HELA CELL; HERPES SIMPLEX VIRUS; HOST CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; VIRUS GENE;

ADENOVIRUS E1A PROTEINS; AMINO ACID SEQUENCE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; ZINC FINGERS;

ADENOVIRIDAE; CAENORHABDITIS ELEGANS; DNA VIRUSES; HERPES; MAMMALIA; NEMATODA; SIMPLEXVIRUS;

EID: 0033587187     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/20466     Document Type: Article

References (28)

1. Whyte, P., Williamson, N. M. & Harlow, E. Cellular targets for transformation by the adenovirus E1A. Cell 56, 67-75 (1989).
2. Zhu, L. et al. Growth suppression by members of the retinoblastoma protein family. Cold Spring Harbor Symp. Quant. Biol. 59, 75-84 (1994).
3. Arany, Z., Sellers, W. R., Livingston, D. M. & Eckner, R. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell 77, 799-800 (1994).
4. Meyer, V. E. & Young, R. A. RNA polymerase II holoenzymes and subcomplexes. J. Biol. Chem. 273, 27757-27760 (1998).
5. Myers, L. C. et al. The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev. 12, 45-54 (1998).
6. Singh, N. & Han, M. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabiditis elegans vulval induction. Genes Dev. 9, 2251-2265 (1995).
7. Boyer, T. G. & Berk, A. J. Functional interaction of adenovirus E1A with holo-TFIID. Genes Dev. 7, 1810-1823 (1993).
8. Webster, L. C. & Ricciardi, R. P. trans-Dominant mutants of E1A provide genetic evidence that the zinc finger of the transactivating domain binds a transcription factor. Mol. Cell Biol. 11, 4287-4296 (1991).
9. Brauer, A. W., Oman, C. L. & Margolies, M. N. Use of o-phthalaldehyde to reduce background during automated Edman degradation. Analyt. Biochem. 137, 134-142 (1984).
10. Graham, F. L., Smiley, J., Russell, W. & Nairn, R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59-74 (1977).
11. Flint, J. & Shenk, T. Adenovirus E1A protein: paradigm viral transactivator. Annu. Rev. Genet. 23, 141-161 (1989).
12. Tassan, J.-P., Jaquenoud, M., Leopold, P., Schultz, S. J. & Nigg, E. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl Acad. Sci. USA 92, 8871-8875 (1995).
13. Liao, S. M. et al. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374, 193-196 (1995).
14. Rickert, P., Seghezzi, W., Shanahan, F., Cho, H. & Lees, E. Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. Oncogene 12, 2631-2640 (1996).
15. Gold, M. O., Tassan, J.-P., Nigg, E. A., Rice, A. P. & Herrmann, C. H. Viral transactivators E1A and VP16 interact with a large complex that is associated with CTD kinase activity and contains CDK8. Nucleic Acids Res. 24, 3771-3777 (1996).
16. Jiang, Y. W. et al. Mammalian mediator of transcriptional regulation and its possible role as an endpoint of signal transduction pathways. Proc. Natl Acad Sci. USA 95, 8538-8543 (1998).
17. Greenblattn, J. RNA polymerase II holoenzyme and transcriptional regulation. Curr. Opin. Cell Biol. 9, 310-319 (1997).
18. Kaiser, K. & Meisterernst, M. The human general co-factors. Trends Biochem. Sci. 9, 342-345 (1996).
19. Janknecht, R. & Nordheim, A. Gene regulation by Ets proteins. Biochem. Biophys. Acta 1155, 346-356 (1993).
20. Faris, M., Kokot, N., Lee, L. & Nel, A. E. Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation. J. Biol. Chem. 271, 27366-27373 (1996).
21. Denhardt, D. T. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho protein in the mammalian cell: the potential for multiplex signalling. Biochem. J. 318, 729-747 (1996).
22. Sun, X. et al. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. Mol Cell 2, 213-222 (1998).
23. Cho, H. et al. A human RNA polymerase II complex containing factors that modify chromatin structure. Mol. Cell. Biol 18, 5355-5363 (1998).
24. Gu, W. et al. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol. Cell 3, 97-108 (1999).
25. Ryu, S., Zhou, S., Ladurner, A. G. & Tijan, R. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1I. Nature 397, 446-450 (1999).
26. Holstege, F. C. P. et al. Dissecting the regulatory circuitry ofa eukaryotic genome. Cell 95, 717-728 (1998).
27. Mes-Masson, A. M., McLaughlin, J., Daley, G. Q., Paskind, M. & Witte, O. N. Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome. Proc. Natl Acad Sci. USA 83, 9768-9772 (1986).
28. Bryant, G. O., Martel, L. S., Burley, S. K. & Berk, A. J. Radical mutagenesis reveals TATA-box binding protein surfaces required for activated transcription in vivo. Genes Dev. 10, 2491-2504 (1996).