Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

Science

Volumn 354, Issue 6309, 2016, Pages 233-237

  Mylona, Anastasia ^a,d   Theillet, Francois Xavier ^b,e   Foster, Charles ^a   Cheng, Tammy M ^a   Miralles, Francesc ^a,c   Bates, Paul A ^a   Selenko, Philipp ^b   Treisman, Richard ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c ST GEORGE S HOSPITAL   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR ELK 1; SERUM RESPONSE FACTOR;

MUTATION; NUCLEAR MAGNETIC RESONANCE; PHOSPHATASE; PHOSPHATE; PROTEIN; SERUM;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MOLECULAR DOCKING; MOLECULAR INTERACTION; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION; ANIMAL; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ENZYME ACTIVATION; ETS-DOMAIN PROTEIN ELK-1; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PROTEIN DOMAINS; SERUM RESPONSE FACTOR;

EID: 84991619629     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad1872     Document Type: Article

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