Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics

Cell Reports

Volumn 15, Issue 2, 2016, Pages 436-450

  Poss, Zachary C ^a   Ebmeier, Christopher C ^a   Odell, Aaron T ^a   Tangpeerachaikul, Anupong ^b   Lee, Thomas ^a   Pelish, Henry E ^b   Shair, Matthew D ^b   Dowell, Robin D ^a   Old, William M ^a   Taatjes, Dylan J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

CDK8 Mediator; Cholesterol; MED13; MED13L; Mediator; SILAC; SIRT1

Indexed keywords

CORTISTATIN A; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 19; CYCLIN DEPENDENT KINASE 8; PHOSPHOTRANSFERASE INHIBITOR; PROTEOME; RNA POLYMERASE II; UNCLASSIFIED DRUG; PHOSPHOPROTEIN; POLYCYCLIC HYDROCARBON; PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ARTICLE; CHROMATIN; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; GENE EXPRESSION; HUMAN; HUMAN CELL; METABOLIC REGULATION; PRIORITY JOURNAL; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA SEQUENCE; SIGNAL TRANSDUCTION; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENE KNOCKDOWN; GENETIC TRANSCRIPTION; HCT 116 CELL LINE; METABOLISM; PROCEDURES; REPRODUCIBILITY;

CYCLIN-DEPENDENT KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; PHOSPHOPROTEINS; POLYCYCLIC COMPOUNDS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEOME; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 84962054069     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.03.030     Document Type: Article

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