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Volumn 144, Issue 20, 2017, Pages 3646-3658

The three-dimensional genome: Regulating gene expression during pluripotency and development

Author keywords

3D chromatin structure; Enhancers; Gene regulation; Non coding mutations; Stem cells

Indexed keywords

CELL LINEAGE; CELL MATURATION; CHROMATIN; CYTOARCHITECTURE; ENHANCER REGION; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENOME; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; ANIMAL; CELL NUCLEUS; CHEMISTRY; CHROMATIN IMMUNOPRECIPITATION; CRISPR CAS SYSTEM; CYTOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENOMICS; METABOLISM; MOUSE;

EID: 85032014269     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.148304     Document Type: Review
Times cited : (84)

References (119)
  • 2
    • 58149463874 scopus 로고    scopus 로고
    • Chromosomal dynamics at the Shh locus: Limb bud-specific differential regulation of competence and active transcription
    • Amano, T., Sagai, T., Tanabe, H., Mizushina, Y., Nakazawa, H. and Shiroishi, T. (2009). Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Dev. Cell 16, 47-57.
    • (2009) Dev. Cell , vol.16 , pp. 47-57
    • Amano, T.1    Sagai, T.2    Tanabe, H.3    Mizushina, Y.4    Nakazawa, H.5    Shiroishi, T.6
  • 4
    • 84988810647 scopus 로고    scopus 로고
    • CRISPR/Cas9 genome editing in embryonic stem cells
    • Andrey, G. and Spielmann, M. (2017). CRISPR/Cas9 genome editing in embryonic stem cells. Methods Mol. Biol. 1468, 221-234.
    • (2017) Methods Mol. Biol , vol.1468 , pp. 221-234
    • Andrey, G.1    Spielmann, M.2
  • 8
    • 84874381107 scopus 로고    scopus 로고
    • Genome-wide quantitative enhancer activity maps identified by STARR-seq
    • Arnold, C. D., Gerlach, D., Stelzer, C., Boryn, L. M., Rath, M. and Stark, A. (2013). Genome-wide quantitative enhancer activity maps identified by STARR-seq. Science 339, 1074-1077.
    • (2013) Science , vol.339 , pp. 1074-1077
    • Arnold, C.D.1    Gerlach, D.2    Stelzer, C.3    Boryn, L.M.4    Rath, M.5    Stark, A.6
  • 9
    • 85012155358 scopus 로고    scopus 로고
    • Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution
    • Arnold, C. D., Zabidi, M. A., Pagani, M., Rath, M., Schernhuber, K., Kazmar, T. and Stark, A. (2017). Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution. Nat. Biotechnol. 35, 136-144.
    • (2017) Nat. Biotechnol , vol.35 , pp. 136-144
    • Arnold, C.D.1    Zabidi, M.A.2    Pagani, M.3    Rath, M.4    Schernhuber, K.5    Kazmar, T.6    Stark, A.7
  • 10
    • 0019811465 scopus 로고
    • Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences
    • Banerji, J., Rusconi, S. and Schaffner, W. (1981). Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell 27, 299-308.
    • (1981) Cell , vol.27 , pp. 299-308
    • Banerji, J.1    Rusconi, S.2    Schaffner, W.3
  • 11
    • 84962648703 scopus 로고    scopus 로고
    • Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping
    • Bartman, C. R., Hsu, S. C., Hsiung, C. C.-S., Raj, A. and Blobel, G. A. (2016). Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping. Mol. Cell 62, 237-247.
    • (2016) Mol. Cell , vol.62 , pp. 237-247
    • Bartman, C.R.1    Hsu, S.C.2    Hsiung, C.C.3    Raj, A.4    Blobel, G.A.5
  • 16
    • 84991585399 scopus 로고    scopus 로고
    • Organization and function of the 3D genome
    • Bonev, B. and Cavalli, G. (2016). Organization and function of the 3D genome. Nat. Rev. Genet. 17, 661-678.
    • (2016) Nat. Rev. Genet , vol.17 , pp. 661-678
    • Bonev, B.1    Cavalli, G.2
  • 17
    • 84940511295 scopus 로고    scopus 로고
    • Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo
    • Bothma, J. P., Garcia, H. G., Ng, S., Perry, M. W., Gregor, T. and Levine, M. (2015). Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo. eLife 4.
    • (2015) Elife , pp. 4
    • Bothma, J.P.1    Garcia, H.G.2    Ng, S.3    Perry, M.W.4    Gregor, T.5    Levine, M.6
  • 18
    • 84943358548 scopus 로고    scopus 로고
    • Architectural hallmarks of the pluripotent genome
    • Bouwman, B. A. M. and de Laat, W. (2015). Architectural hallmarks of the pluripotent genome. FEBS Lett. 589, 2905-2913.
    • (2015) FEBS Lett , vol.589 , pp. 2905-2913
    • Bouwman, B.A.M.1    De Laat, W.2
  • 19
    • 84888877924 scopus 로고    scopus 로고
    • Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
    • Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y. and Greenleaf, W. J. (2013). Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat. Methods 10, 1213-1218.
    • (2013) Nat. Methods , vol.10 , pp. 1213-1218
    • Buenrostro, J.D.1    Giresi, P.G.2    Zaba, L.C.3    Chang, H.Y.4    Greenleaf, W.J.5
  • 25
    • 84886853624 scopus 로고    scopus 로고
    • Topology of mammalian developmental enhancers and their regulatory landscapes
    • de Laat, W. and Duboule, D. (2013). Topology of mammalian developmental enhancers and their regulatory landscapes. Nature 502, 499-506.
    • (2013) Nature , vol.502 , pp. 499-506
    • De Laat, W.1    Duboule, D.2
  • 27
    • 84861964135 scopus 로고    scopus 로고
    • Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor
    • Deng, W., Lee, J., Wang, H., Miller, J., Reik, A., Gregory, P. D., Dean, A. and Blobel, G. A. (2012). Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell 149, 1233-1244.
    • (2012) Cell , vol.149 , pp. 1233-1244
    • Deng, W.1    Lee, J.2    Wang, H.3    Miller, J.4    Reik, A.5    Gregory, P.D.6    Dean, A.7    Blobel, G.A.8
  • 29
    • 85027929606 scopus 로고    scopus 로고
    • Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization
    • Denholtz, M., Bonora, G., Chronis, C., Splinter, E., de Laat, W., Ernst, J., Pellegrini, M. and Plath, K. (2013). Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization. Cell Stem Cell 13, 602-616.
    • (2013) Cell Stem Cell , vol.13 , pp. 602-616
    • Denholtz, M.1    Bonora, G.2    Chronis, C.3    Splinter, E.4    De Laat, W.5    Ernst, J.6    Pellegrini, M.7    Plath, K.8
  • 30
    • 84885393469 scopus 로고    scopus 로고
    • Transcriptional regulation by Polycomb group proteins
    • Di Croce, L. and Helin, K. (2013). Transcriptional regulation by Polycomb group proteins. Nat. Struct. Mol. Biol. 20, 1147-1155.
    • (2013) Nat. Struct. Mol. Biol , vol.20 , pp. 1147-1155
    • Di Croce, L.1    Helin, K.2
  • 31
    • 84861095603 scopus 로고    scopus 로고
    • Topological domains in mammalian genomes identified by analysis of chromatin interactions
    • Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J. S. and Ren, B. (2012). Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485, 376-380.
    • (2012) Nature , vol.485 , pp. 376-380
    • Dixon, J.R.1    Selvaraj, S.2    Yue, F.3    Kim, A.4    Li, Y.5    Shen, Y.6    Hu, M.7    Liu, J.S.8    Ren, B.9
  • 33
    • 84971406209 scopus 로고    scopus 로고
    • Chromatin domains: The unit of chromosome organization
    • Dixon, J. R., Gorkin, D. U. and Ren, B. (2016). Chromatin domains: the unit of chromosome organization. Mol. Cell 62, 668-680.
    • (2016) Mol. Cell , vol.62 , pp. 668-680
    • Dixon, J.R.1    Gorkin, D.U.2    Ren, B.3
  • 34
    • 34248524473 scopus 로고    scopus 로고
    • Mapping networks of physical interactions between genomic elements using 5C technology
    • Dostie, J. and Dekker, J. (2007). Mapping networks of physical interactions between genomic elements using 5C technology. Nat. Protoc. 2, 988-1002.
    • (2007) Nat. Protoc , vol.2 , pp. 988-1002
    • Dostie, J.1    Dekker, J.2
  • 36
    • 5444255213 scopus 로고    scopus 로고
    • The active spatial organization of the beta-globin locus requires the transcription factor EKLF
    • Drissen, R., Palstra, R. J., Gillemans, N., Splinter, E., Grosveld, F., Philipsen, S. and de Laat, W. (2004). The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev. 18, 2485-2490.
    • (2004) Genes Dev , vol.18 , pp. 2485-2490
    • Drissen, R.1    Palstra, R.J.2    Gillemans, N.3    Splinter, E.4    Grosveld, F.5    Philipsen, S.6    De Laat, W.7
  • 37
    • 77954922964 scopus 로고    scopus 로고
    • Activator-Mediator binding regulates Mediator-cofactor interactions
    • Ebmeier, C. C. and Taatjes, D. J. (2010). Activator-Mediator binding regulates Mediator-cofactor interactions. Proc. Natl. Acad. Sci. USA 107, 11283-11288.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 11283-11288
    • Ebmeier, C.C.1    Taatjes, D.J.2
  • 49
    • 84995810181 scopus 로고    scopus 로고
    • Insulated neighborhoods: Structural and functional units of mammalian gene control
    • Hnisz, D., Day, D. S. and Young, R. A. (2016). Insulated neighborhoods: structural and functional units of mammalian gene control. Cell 167, 1188-1200.
    • (2016) Cell , vol.167 , pp. 1188-1200
    • Hnisz, D.1    Day, D.S.2    Young, R.A.3
  • 50
    • 85017104605 scopus 로고    scopus 로고
    • Chromatin architecture emerges during zygotic genome activation independent of transcription
    • Hug, C. B., Grimaldi, A. G., Kruse, K. and Vaquerizas, J. M. (2017). Chromatin architecture emerges during zygotic genome activation independent of transcription. Cell 169, 216-228.e219.
    • (2017) Cell , vol.169 , pp. 216-228
    • Hug, C.B.1    Grimaldi, A.G.2    Kruse, K.3    Vaquerizas, J.M.4
  • 55
    • 0033617267 scopus 로고    scopus 로고
    • Breaking colinearity in the mouse HoxD complex
    • Kondo, T. and Duboule, D. (1999). Breaking colinearity in the mouse HoxD complex. Cell 97, 407-417.
    • (1999) Cell , vol.97 , pp. 407-417
    • Kondo, T.1    Duboule, D.2
  • 60
    • 40349084105 scopus 로고    scopus 로고
    • Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells
    • Levasseur, D. N., Wang, J., Dorschner, M. O., Stamatoyannopoulos, J. A. and Orkin, S. H. (2008). Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes Dev. 22, 575-580.
    • (2008) Genes Dev , vol.22 , pp. 575-580
    • Levasseur, D.N.1    Wang, J.2    Dorschner, M.O.3    Stamatoyannopoulos, J.A.4    Orkin, S.H.5
  • 61
    • 84915816838 scopus 로고    scopus 로고
    • CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells
    • Li, Y., Rivera, C. M., Ishii, H., Jin, F., Selvaraj, S., Lee, A. Y., Dixon, J. R. and Ren, B. (2014). CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells. PLoS ONE 9, e114485.
    • (2014) Plos ONE , vol.9
    • Li, Y.1    Rivera, C.M.2    Ishii, H.3    Jin, F.4    Selvaraj, S.5    Lee, A.Y.6    Dixon, J.R.7    Ren, B.8
  • 64
    • 84911895715 scopus 로고    scopus 로고
    • Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci
    • Lonfat, N., Montavon, T., Darbellay, F., Gitto, S. and Duboule, D. (2014). Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci. Science 346, 1004-1006.
    • (2014) Science , vol.346 , pp. 1004-1006
    • Lonfat, N.1    Montavon, T.2    Darbellay, F.3    Gitto, S.4    Duboule, D.5
  • 65
    • 84995753074 scopus 로고    scopus 로고
    • Ever-changing landscapes: Transcriptional enhancers in development and evolution
    • Long, H. K., Prescott, S. L. and Wysocka, J. (2016). Ever-changing landscapes: transcriptional enhancers in development and evolution. Cell 167, 1170-1187.
    • (2016) Cell , vol.167 , pp. 1170-1187
    • Long, H.K.1    Prescott, S.L.2    Wysocka, J.3
  • 67
    • 84956894592 scopus 로고    scopus 로고
    • Breaking TADs: How alterations of chromatin domains result in disease
    • Lupiáñez, D. G., Spielmann, M. and Mundlos, S. (2016). Breaking TADs: how alterations of chromatin domains result in disease. Trends Genet. 32, 225-237.
    • (2016) Trends Genet , vol.32 , pp. 225-237
    • Lupiáñez, D.G.1    Spielmann, M.2    Mundlos, S.3
  • 69
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron, R. and Reinberg, D. (2011). The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349.
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 70
    • 84875249885 scopus 로고    scopus 로고
    • An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape
    • Marinić, M., Aktas, T., Ruf, S. and Spitz, F. (2013). An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev. Cell 24, 530-542.
    • (2013) Dev. Cell , vol.24 , pp. 530-542
    • Marinić, M.1    Aktas, T.2    Ruf, S.3    Spitz, F.4
  • 71
    • 79251558860 scopus 로고    scopus 로고
    • Chromatin plasticity in pluripotent cells
    • Melcer, S. and Meshorer, E. (2010). Chromatin plasticity in pluripotent cells. Essays Biochem. 48, 245-262.
    • (2010) Essays Biochem , vol.48 , pp. 245-262
    • Melcer, S.1    Meshorer, E.2
  • 72
    • 29744447772 scopus 로고    scopus 로고
    • Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells
    • Meshorer, E., Yellajoshula, D., George, E., Scambler, P. J., Brown, D. T. and Misteli, T. (2006). Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev. Cell 10, 105-116.
    • (2006) Dev. Cell , vol.10 , pp. 105-116
    • Meshorer, E.1    Yellajoshula, D.2    George, E.3    Scambler, P.J.4    Brown, D.T.5    Misteli, T.6
  • 73
    • 38949109998 scopus 로고    scopus 로고
    • Modeling Hox gene regulation in digits: Reverse collinearity and the molecular origin of thumbness
    • Montavon, T., Le Garrec, J.-F., Kerszberg, M. and Duboule, D. (2008). Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness. Genes Dev. 22, 346-359.
    • (2008) Genes Dev , vol.22 , pp. 346-359
    • Montavon, T.1    Le Garrec, J.-F.2    Kerszberg, M.3    Duboule, D.4
  • 78
    • 0141730403 scopus 로고    scopus 로고
    • The beta-globin nuclear compartment in development and erythroid differentiation. Nat
    • Palstra, R.-J., Tolhuis, B., Splinter, E., Nijmeijer, R., Grosveld, F. and de Laat, W. (2003). The beta-globin nuclear compartment in development and erythroid differentiation. Nat. Genet. 35, 190-194.
    • (2003) Genet , vol.35 , pp. 190-194
    • Palstra, R.-J.1    Tolhuis, B.2    Splinter, E.3    Nijmeijer, R.4    Grosveld, F.5    De Laat, W.6
  • 79
    • 45749154811 scopus 로고    scopus 로고
    • Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription
    • Palstra, R.-J., Simonis, M., Klous, P., Brasset, E., Eijkelkamp, B. and de Laat, W. (2008). Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription. PLoS ONE 3, e1661.
    • (2008) Plos ONE , pp. 3
    • Palstra, R.-J.1    Simonis, M.2    Klous, P.3    Brasset, E.4    Eijkelkamp, B.5    De Laat, W.6
  • 82
    • 85011623248 scopus 로고    scopus 로고
    • Limb development: A paradigm of gene regulation
    • Petit, F., Sears, K. E. and Ahituv, N. (2017). Limb development: a paradigm of gene regulation. Nat. Rev. Genet. 18, 245-258.
    • (2017) Nat. Rev. Genet , vol.18 , pp. 245-258
    • Petit, F.1    Sears, K.E.2    Ahituv, N.3
  • 86
    • 79951516056 scopus 로고    scopus 로고
    • A unique chromatin signature uncovers early developmental enhancers in humans
    • Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A. and Wysocka, J. (2011). A unique chromatin signature uncovers early developmental enhancers in humans. Nature 470, 279-283.
    • (2011) Nature , vol.470 , pp. 279-283
    • Rada-Iglesias, A.1    Bajpai, R.2    Swigut, T.3    Brugmann, S.A.4    Flynn, R.A.5    Wysocka, J.6
  • 88
    • 79953176250 scopus 로고    scopus 로고
    • Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor
    • Ruf, S., Symmons, O., Uslu, V. V., Dolle, D., Hot, C., Ettwiller, L. and Spitz, F. (2011). Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Nat. Genet. 43, 379-386.
    • (2011) Nat. Genet , vol.43 , pp. 379-386
    • Ruf, S.1    Symmons, O.2    Uslu, V.V.3    Dolle, D.4    Hot, C.5    Ettwiller, L.6    Spitz, F.7
  • 89
    • 14844341770 scopus 로고    scopus 로고
    • Elimination of a long-range cis-regulatory module causes complete loss of limbspecific Shh expression and truncation of the mouse limb
    • Sagai, T., Hosoya, M., Mizushina, Y., Tamura, M. and Shiroishi, T. (2005). Elimination of a long-range cis-regulatory module causes complete loss of limbspecific Shh expression and truncation of the mouse limb. Development 132, 797-803.
    • (2005) Development , vol.132 , pp. 797-803
    • Sagai, T.1    Hosoya, M.2    Mizushina, Y.3    Tamura, M.4    Shiroishi, T.5
  • 91
    • 84865800494 scopus 로고    scopus 로고
    • The long-range interaction landscape of gene promoters
    • Sanyal, A., Lajoie, B. R., Jain, G. and Dekker, J. (2012). The long-range interaction landscape of gene promoters. Nature 489, 109-113.
    • (2012) Nature , vol.489 , pp. 109-113
    • Sanyal, A.1    Lajoie, B.R.2    Jain, G.3    Dekker, J.4
  • 92
    • 84964681430 scopus 로고    scopus 로고
    • Chromosome conformation capture technologies and their impact in understanding genome function
    • Sati, S. and Cavalli, G. (2017). Chromosome conformation capture technologies and their impact in understanding genome function. Chromosoma 126, 33-44.
    • (2017) Chromosoma , vol.126 , pp. 33-44
    • Sati, S.1    Cavalli, G.2
  • 95
    • 84899450857 scopus 로고    scopus 로고
    • Transcriptional enhancers: From properties to genome-wide predictions
    • Shlyueva, D., Stampfel, G. and Stark, A. (2014). Transcriptional enhancers: from properties to genome-wide predictions. Nat. Rev. Genet. 15, 272-286.
    • (2014) Nat. Rev. Genet , vol.15 , pp. 272-286
    • Shlyueva, D.1    Stampfel, G.2    Stark, A.3
  • 96
    • 33750212321 scopus 로고    scopus 로고
    • Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C)
    • Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., van Steensel, B. and de Laat, W. (2006). Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat. Genet. 38, 1348-1354.
    • (2006) Nat. Genet , vol.38 , pp. 1348-1354
    • Simonis, M.1    Klous, P.2    Splinter, E.3    Moshkin, Y.4    Willemsen, R.5    De Wit, E.6    Van Steensel, B.7    De Laat, W.8
  • 97
    • 77956276383 scopus 로고    scopus 로고
    • DNase-seq: A high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells
    • 2010, pdb prot5384
    • Song, L. and Crawford, G. E. (2010). DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells. Cold Spring Harb. Protoc. 2010, pdb prot5384.
    • (2010) Cold Spring Harb. Protoc
    • Song, L.1    Crawford, G.E.2
  • 98
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: From enhancer binding to developmental control
    • Spitz, F. and Furlong, E. E. M. (2012). Transcription factors: from enhancer binding to developmental control. Nat. Rev. Genet. 13, 613-626.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.M.2
  • 101
    • 85000885269 scopus 로고    scopus 로고
    • The Shh topological domain facilitates the action of remote enhancers by reducing the effects of genomic distances
    • Symmons, O., Pan, L., Remeseiro, S., Aktas, T., Klein, F., Huber, W. and Spitz, F. (2016). The Shh topological domain facilitates the action of remote enhancers by reducing the effects of genomic distances. Dev. Cell 39, 529-543.
    • (2016) Dev. Cell , vol.39 , pp. 529-543
    • Symmons, O.1    Pan, L.2    Remeseiro, S.3    Aktas, T.4    Klein, F.5    Huber, W.6    Spitz, F.7
  • 103
    • 0036923833 scopus 로고    scopus 로고
    • Looping and interaction between hypersensitive sites in the active beta-globin locus
    • Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F. and de Laat, W. (2002). Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol. Cell 10, 1453-1465.
    • (2002) Mol. Cell , vol.10 , pp. 1453-1465
    • Tolhuis, B.1    Palstra, R.-J.2    Splinter, E.3    Grosveld, F.4    De Laat, W.5
  • 104
    • 84924366664 scopus 로고    scopus 로고
    • A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes
    • Tsujimura, T., Klein, F. A., Langenfeld, K., Glaser, J., Huber, W. and Spitz, F. (2015). A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes. PLoS Genet. 11, e1004897.
    • (2015) Plos Genet , vol.11
    • Tsujimura, T.1    Klein, F.A.2    Langenfeld, K.3    Glaser, J.4    Huber, W.5    Spitz, F.6
  • 105
    • 23044431656 scopus 로고    scopus 로고
    • Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin
    • Vakoc, C. R., Mandat, S. A., Olenchock, B. A. and Blobel, G. A. (2005). Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol. Cell 19, 381-391.
    • (2005) Mol. Cell , vol.19 , pp. 381-391
    • Vakoc, C.R.1    Mandat, S.A.2    Olenchock, B.A.3    Blobel, G.A.4
  • 107
    • 34247272882 scopus 로고    scopus 로고
    • Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression
    • Vernimmen, D., De Gobbi, M., Sloane-Stanley, J. A., Wood, W. G. and Higgs, D. R. (2007). Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression. EMBO J. 26, 2041-2051.
    • (2007) EMBO J , vol.26 , pp. 2041-2051
    • Vernimmen, D.1    De Gobbi, M.2    Sloane-Stanley, J.A.3    Wood, W.G.4    Higgs, D.R.5
  • 108
    • 33846112470 scopus 로고    scopus 로고
    • VISTA Enhancer Browser–a database of tissue-specific human enhancers
    • Visel, A., Minovitsky, S., Dubchak, I. and Pennacchio, L. A. (2007). VISTA Enhancer Browser–a database of tissue-specific human enhancers. Nucleic Acids Res. 35, D88-D92.
    • (2007) Nucleic Acids Res , vol.35 , pp. D88-D92
    • Visel, A.1    Minovitsky, S.2    Dubchak, I.3    Pennacchio, L.A.4
  • 109
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A.W., Zhang, F. and Jaenisch, R. (2013). One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153, 910-918.
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3    Dawlaty, M.M.4    Cheng, A.W.5    Zhang, F.6    Jaenisch, R.7
  • 110
    • 84887835943 scopus 로고    scopus 로고
    • Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency
    • Wei, Z., Gao, F., Kim, S., Yang, H., Lyu, J., An, W., Wang, K. and Lu, W. (2013). Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency. Cell Stem Cell 13, 36-47.
    • (2013) Cell Stem Cell , vol.13 , pp. 36-47
    • Wei, Z.1    Gao, F.2    Kim, S.3    Yang, H.4    Lyu, J.5    An, W.6    Wang, K.7    Lu, W.8
  • 114
    • 84983072055 scopus 로고    scopus 로고
    • Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity
    • Williamson, I., Lettice, L. A., Hill, R. E. and Bickmore, W. A. (2016). Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity. Development 143, 2994-3001.
    • (2016) Development , vol.143 , pp. 2994-3001
    • Williamson, I.1    Lettice, L.A.2    Hill, R.E.3    Bickmore, W.A.4
  • 116
    • 85017425829 scopus 로고    scopus 로고
    • Multiplexed engineering and analysis of combinatorial enhancer activity in single cells
    • Xie, S., Duan, J., Li, B., Zhou, P. and Hon, G. C. (2017). Multiplexed engineering and analysis of combinatorial enhancer activity in single cells. Mol. Cell 66, 285-299.e285.
    • (2017) Mol. Cell , vol.66 , pp. 285-299
    • Xie, S.1    Duan, J.2    Li, B.3    Zhou, P.4    Hon, G.C.5
  • 117
    • 84925543087 scopus 로고    scopus 로고
    • Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation
    • Zabidi, M. A., Arnold, C. D., Schernhuber, K., Pagani, M., Rath, M., Frank, O. and Stark, A. (2015). Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation. Nature 518, 556-559.
    • (2015) Nature , vol.518 , pp. 556-559
    • Zabidi, M.A.1    Arnold, C.D.2    Schernhuber, K.3    Pagani, M.4    Rath, M.5    Frank, O.6    Stark, A.7
  • 118
    • 70449805406 scopus 로고    scopus 로고
    • Vertebrate limb bud development: Moving towards integrative analysis of organogenesis
    • Zeller, R., López-Ríos, J. and Zuniga, A. (2009). Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat. Rev. Genet. 10, 845-858.
    • (2009) Nat. Rev. Genet , vol.10 , pp. 845-858
    • Zeller, R.1    López-Ríos, J.2    Zuniga, A.3
  • 119
    • 85016499498 scopus 로고    scopus 로고
    • Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes
    • Zhan, Y., Mariani, L., Barozzi, I., Schulz, E. G., Blüthgen, N., Stadler, M., Tiana, G. and Giorgetti, L. (2017). Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes. Genome Res. 27, 479-490.
    • (2017) Genome Res , vol.27 , pp. 479-490
    • Zhan, Y.1    Mariani, L.2    Barozzi, I.3    Schulz, E.G.4    Blüthgen, N.5    Stadler, M.6    Tiana, G.7    Giorgetti, L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.