-
2
-
-
0018240421
-
A gene complex controlling segmentation in Drosophila
-
Lewis, E. B. A gene complex controlling segmentation in Drosophila. Nature 276, 565-570 (1978).
-
(1978)
Nature
, vol.276
, pp. 565-570
-
-
Lewis, E.B.1
-
3
-
-
70350149728
-
Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice
-
Schuettengruber, B. & Cavalli, G. Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development 136, 3531-3542 (2009).
-
(2009)
Development
, vol.136
, pp. 3531-3542
-
-
Schuettengruber, B.1
Cavalli, G.2
-
4
-
-
33745151459
-
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities
-
Klymenko, T. et al. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev. 20, 1110-1122 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 1110-1122
-
-
Klymenko, T.1
-
5
-
-
77952429798
-
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
-
Scheuermann, J. C. et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465, 243-247 (2010).
-
(2010)
Nature
, vol.465
, pp. 243-247
-
-
Scheuermann, J.C.1
-
6
-
-
70349469565
-
Mechanisms of polycomb gene silencing: Knowns and unknowns
-
Simon, J. A. & Kingston, R. E. Mechanisms of polycomb gene silencing: knowns and unknowns. Nature Rev. Mol. Cell Biol. 10, 697-708 (2009).
-
(2009)
Nature Rev. Mol. Cell Biol.
, vol.10
, pp. 697-708
-
-
Simon, J.A.1
Kingston, R.E.2
-
7
-
-
77951947926
-
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination
-
Eskeland, R. et al. Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol. Cell 38, 452-464 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 452-464
-
-
Eskeland, R.1
-
8
-
-
55449105221
-
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
-
Ku, M. et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 4, E1000242 (2008).
-
(2008)
PLoS Genet.
, vol.4
-
-
Ku, M.1
-
9
-
-
69449086947
-
A vertebrate Polycomb response element governs segmentation of the posterior hindbrain
-
Sing, A. et al. A vertebrate Polycomb response element governs segmentation of the posterior hindbrain. Cell 138, 885-897 (2009).
-
(2009)
Cell
, vol.138
, pp. 885-897
-
-
Sing, A.1
-
10
-
-
33746407708
-
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
-
Schoeftner, S. et al. Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J. 25, 3110-3122 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 3110-3122
-
-
Schoeftner, S.1
-
11
-
-
34848812584
-
Polycomb Group proteins: An evolutionary perspective
-
Whitcomb, S. J., Basu, A., Allis, C. D. & Bernstein, E. Polycomb Group proteins: an evolutionary perspective. Trends Genet. 23, 494-502 (2007).
-
(2007)
Trends Genet.
, vol.23
, pp. 494-502
-
-
Whitcomb, S.J.1
Basu, A.2
Allis, C.D.3
Bernstein, E.4
-
12
-
-
77954676296
-
Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas
-
Shaver, S., Casas-Mollano, J. A., Cerny, R. L. & Cerutti, H. Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas. Epigenetics 5, 301-302 (2010).
-
(2010)
Epigenetics
, vol.5
, pp. 301-302
-
-
Shaver, S.1
Casas-Mollano, J.A.2
Cerny, R.L.3
Cerutti, H.4
-
13
-
-
41949089616
-
ESC ESCL and their roles in Polycomb Group mechanisms
-
Ohno, K., McCabe, D., Czermin, B., Imhof, A. & Pirrotta, V. ESC, ESCL and their roles in Polycomb Group mechanisms. Mech. Dev. 125, 527-541 (2008).
-
(2008)
Mech. Dev.
, vol.125
, pp. 527-541
-
-
Ohno, K.1
McCabe, D.2
Czermin, B.3
Imhof, A.4
Pirrotta, V.5
-
14
-
-
55949132133
-
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
-
Margueron, R. et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol. Cell 32, 503-518 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 503-518
-
-
Margueron, R.1
-
15
-
-
69449097106
-
Diversity of Polycomb group complexes in plants: Same rules Different players?
-
Hennig, L. & Derkacheva, M. Diversity of Polycomb group complexes in plants: same rules, Different players? Trends Genet. 25, 414-423 (2009).
-
(2009)
Trends Genet.
, vol.25
, pp. 414-423
-
-
Hennig, L.1
Derkacheva, M.2
-
16
-
-
55949124844
-
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
-
Shen, X. et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 32, 491-502 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 491-502
-
-
Shen, X.1
-
17
-
-
3042801308
-
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
-
Cao, R. & Zhang, Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57-67 (2004).
-
(2004)
Mol. Cell
, vol.15
, pp. 57-67
-
-
Cao, R.1
Zhang, Y.2
-
18
-
-
66249121737
-
AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2
-
Kim, H., Kang, K. & Kim, J. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Nucleic Acids Res. 37, 2940-2950 (2009).
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 2940-2950
-
-
Kim, H.1
Kang, K.2
Kim, J.3
-
19
-
-
9244265488
-
A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers
-
Wang, S., Robertson, G. P. & Zhu, J. A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers. Gene 343, 69-78 (2004).
-
(2004)
Gene
, vol.343
, pp. 69-78
-
-
Wang, S.1
Robertson, G.P.2
Zhu, J.3
-
20
-
-
34648834735
-
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
-
Nekrasov, M. et al. Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J. 26, 4078-4088 (2007).
-
(2007)
EMBO J.
, vol.26
, pp. 4078-4088
-
-
Nekrasov, M.1
-
21
-
-
75349104610
-
Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation
-
Walker, E. et al. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell 6, 153-166 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 153-166
-
-
Walker, E.1
-
22
-
-
76749083433
-
Jarid2 and PRC2 Partners in regulating gene expression
-
Li, G. et al. Jarid2 and PRC2, Partners in regulating gene expression. Genes Dev. 24, 368-380 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 368-380
-
-
Li, G.1
-
23
-
-
42149149895
-
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo
-
Sarma, K., Margueron, R., Ivanov, A., Pirrotta, V. & Reinberg, D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol. Cell. Biol. 28, 2718-2731 (2008).
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 2718-2731
-
-
Sarma, K.1
Margueron, R.2
Ivanov, A.3
Pirrotta, V.4
Reinberg, D.5
-
24
-
-
42149149344
-
Recruitment of Drosophila Polycombgroup proteins by Polycomblike A component of a novel protein complex in larvae
-
Savla, U., Benes, J., Zhang, J. & Jones, R. S. Recruitment of Drosophila Polycombgroup proteins by Polycomblike, A component of a novel protein complex in larvae. Development 135, 813-817 (2008).
-
(2008)
Development
, vol.135
, pp. 813-817
-
-
Savla, U.1
Benes, J.2
Zhang, J.3
Jones, R.S.4
-
25
-
-
11244302905
-
Roles of JUMONJI in mouse embryonic development
-
Jung, J., Mysliwiec, M. R. & Lee, Y. Roles of JUMONJI in mouse embryonic development. Dev. Dyn. 232, 21-32 (2005).
-
(2005)
Dev. Dyn.
, vol.232
, pp. 21-32
-
-
Jung, J.1
Mysliwiec, M.R.2
Lee, Y.3
-
26
-
-
72249119297
-
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
-
Peng, J. et al. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139, 1290-1302 (2009).
-
(2009)
Cell
, vol.139
, pp. 1290-1302
-
-
Peng, J.1
-
27
-
-
72249104107
-
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells
-
Shen, X. et al. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 139, 1303-1314 (2009).
-
(2009)
Cell
, vol.139
, pp. 1303-1314
-
-
Shen, X.1
-
28
-
-
77949414371
-
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
-
Pasini, D. et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464, 306-310 (2010).
-
(2010)
Nature
, vol.464
, pp. 306-310
-
-
Pasini, D.1
-
29
-
-
77953120646
-
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
-
Landeira, D. et al. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nature Cell Biol. 12, 618-624 (2010).
-
(2010)
Nature Cell Biol.
, vol.12
, pp. 618-624
-
-
Landeira, D.1
-
30
-
-
77449086407
-
In vivo residue-specific histone methylation dynamics
-
Zee, B. M. et al. In vivo residue-specific histone methylation dynamics. J. Biol. Chem. 285, 3341-3350 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 3341-3350
-
-
Zee, B.M.1
-
31
-
-
9144268924
-
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin
-
Peters, A. H. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12, 1577-1589 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 1577-1589
-
-
Peters, A.H.1
-
32
-
-
70350031643
-
CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing
-
Tie, F. et al. CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development 136, 3131-3141 (2009).
-
(2009)
Development
, vol.136
, pp. 3131-3141
-
-
Tie, F.1
-
33
-
-
34948839944
-
Facultative heterochromatin: Is there a distinctive molecular signature?
-
Trojer, P. & Reinberg, D. Facultative heterochromatin: is there a distinctive molecular signature? Mol. Cell 28, 1-13 (2007).
-
(2007)
Mol Cell
, vol.28
, pp. 1-13
-
-
Trojer, P.1
Reinberg, D.2
-
34
-
-
58049191558
-
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
-
Cui, K. et al. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4, 80-93 (2009).
-
(2009)
Cell Stem Cell
, vol.4
, pp. 80-93
-
-
Cui, K.1
-
35
-
-
67650296444
-
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing
-
Jacob, Y. et al. ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nature Struct. Mol. Biol. 16, 763-768 (2009).
-
(2009)
Nature Struct. Mol. Biol.
, vol.16
, pp. 763-768
-
-
Jacob, Y.1
-
36
-
-
34248169728
-
The polycomb group protein Suz12 is required for embryonic stem cell differentiation
-
Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M. & Helin, K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol. Cell. Biol. 27, 3769-3779 (2007).
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3769-3779
-
-
Pasini, D.1
Bracken, A.P.2
Hansen, J.B.3
Capillo, M.4
Helin, K.5
-
37
-
-
34848815014
-
H3K27 demethylases at long last
-
Swigut, T. & Wysocka, J. H3K27 demethylases, At long last. Cell 131, 29-32 (2007).
-
(2007)
Cell
, vol.131
, pp. 29-32
-
-
Swigut, T.1
Wysocka, J.2
-
38
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007).
-
(2007)
Cell
, vol.129
, pp. 823-837
-
-
Barski, A.1
-
39
-
-
34547624303
-
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
-
Mikkelsen, T. S. et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448, 553-560 (2007).
-
(2007)
Nature
, vol.448
, pp. 553-560
-
-
Mikkelsen, T.S.1
-
40
-
-
36749089980
-
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
-
Stock, J. K. et al. Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nature Cell Biol. 9, 1428-1435 (2007).
-
(2007)
Nature Cell Biol.
, vol.9
, pp. 1428-1435
-
-
Stock, J.K.1
-
41
-
-
34548424709
-
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells
-
Zhao, X. D. et al. Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 1, 286-298 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 286-298
-
-
Zhao, X.D.1
-
42
-
-
77953107585
-
Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2
-
Kanhere, A. et al. Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol. Cell 38, 675-688 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 675-688
-
-
Kanhere, A.1
-
43
-
-
51649129596
-
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
-
Mohn, F. et al. Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol. Cell 30, 755-766 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 755-766
-
-
Mohn, F.1
-
44
-
-
33646865180
-
Control of developmental regulators by Polycomb in human embryonic stem cells
-
Lee, T. I. et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125, 301-313 (2006).
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
-
45
-
-
33646882068
-
Polycomb complexes repress developmental regulators in murine embryonic stem cells
-
Boyer, L. A. et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-353 (2006).
-
(2006)
Nature
, vol.441
, pp. 349-353
-
-
Boyer, L.A.1
-
46
-
-
33646870495
-
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
-
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H. & Helin, K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20, 1123-1136 (2006).
-
(2006)
Genes Dev.
, vol.20
, pp. 1123-1136
-
-
Bracken, A.P.1
Dietrich, N.2
Pasini, D.3
Hansen, K.H.4
Helin, K.5
-
47
-
-
33745604636
-
Suz12 binds to silenced regions of the genome in a celltype-specific manner
-
Squazzo, S. L. et al. Suz12 binds to silenced regions of the genome in a celltype-specific manner. Genome Res. 16, 890-900 (2006).
-
(2006)
Genome Res.
, vol.16
, pp. 890-900
-
-
Squazzo, S.L.1
-
48
-
-
33745225872
-
Genome-wide analysis of Polycomb targets in Drosophila melanogaster
-
Schwartz, Y. B. et al. Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nature Genet. 38, 700-705 (2006).
-
(2006)
Nature Genet.
, vol.38
, pp. 700-705
-
-
Schwartz, Y.B.1
-
49
-
-
33745258986
-
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster
-
Tolhuis, B. et al. Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nature Genet. 38, 694-699 (2006).
-
(2006)
Nature Genet.
, vol.38
, pp. 694-699
-
-
Tolhuis, B.1
-
50
-
-
77953809032
-
Distinct epigenomic landscapes of pluripotent and lineagecommitted human cells
-
Hawkins, R. D. et al. Distinct epigenomic landscapes of pluripotent and lineagecommitted human cells. Cell Stem Cell 6, 479-491 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 479-491
-
-
Hawkins, R.D.1
-
51
-
-
34548434716
-
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells
-
Pan, G. et al. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell 1, 299-312 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 299-312
-
-
Pan, G.1
-
52
-
-
64849110610
-
Determination of enriched histone modifications in nongenic portions of the human genome
-
Rosenfeld, J. A. et al. Determination of enriched histone modifications in nongenic portions of the human genome. BMC Genomics 10, 143 (2009).
-
(2009)
BMC Genomics
, vol.10
, pp. 143
-
-
Rosenfeld, J.A.1
-
53
-
-
76149142791
-
Polycomb complexes act redundantly to repress genomic repeats and genes
-
Leeb, M. et al. Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev. 24, 265-276 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 265-276
-
-
Leeb, M.1
-
54
-
-
77949678340
-
Chromatin structure and the inheritance of epigenetic information
-
Margueron, R. & Reinberg, D. Chromatin structure and the inheritance of epigenetic information. Nature Rev. Genet. 11, 285-296 (2010).
-
(2010)
Nature Rev. Genet.
, vol.11
, pp. 285-296
-
-
Margueron, R.1
Reinberg, D.2
-
55
-
-
77954819820
-
Chromatin plasticity and genome organization in pluripotent embryonic stem cells
-
Mattout, A. & Meshorer, E. Chromatin plasticity and genome organization in pluripotent embryonic stem cells. Curr. Opin. Cell Biol. 22, 334-341 (2010).
-
(2010)
Curr. Opin. Cell Biol.
, vol.22
, pp. 334-341
-
-
Mattout, A.1
Meshorer, E.2
-
56
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326 (2006).
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
-
57
-
-
77950866717
-
Chromatin signature of embryonic pluripotency is established during genome activation
-
Vastenhouw, N. L. et al. Chromatin signature of embryonic pluripotency is established during genome activation. Nature 464, 922-926 (2010).
-
(2010)
Nature
, vol.464
, pp. 922-926
-
-
Vastenhouw, N.L.1
-
58
-
-
58849088872
-
Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos
-
Schuettengruber, B. et al. Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLoS Biol. 7, E13 (2009).
-
(2009)
PLoS Biol
, vol.7
-
-
Schuettengruber, B.1
-
59
-
-
55549148715
-
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment
-
Creyghton, M. P. et al. H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell 135, 649-661 (2008).
-
(2008)
Cell
, vol.135
, pp. 649-661
-
-
Creyghton, M.P.1
-
60
-
-
49649125042
-
Genome-scale DNA methylation maps of pluripotent and differentiated cells
-
Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766-770 (2008).
-
(2008)
Nature
, vol.454
, pp. 766-770
-
-
Meissner, A.1
-
61
-
-
65549107163
-
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver
-
Brunner, A. L. et al. Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res. 19, 1044-1056 (2009).
-
(2009)
Genome Res.
, vol.19
, pp. 1044-1056
-
-
Brunner, A.L.1
-
62
-
-
77952355762
-
Genome-wide evolutionary analysis of eukaryotic DNA methylation
-
Zemach, A., McDaniel, I. E., Silva, P. & Zilberman, D. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science 328, 916-919 (2010).
-
(2010)
Science
, vol.328
, pp. 916-919
-
-
Zemach, A.1
McDaniel, I.E.2
Silva, P.3
Zilberman, D.4
-
63
-
-
73149111929
-
A region of the human HOXD cluster that confers polycomb-group responsiveness
-
Woo, C. J., Kharchenko, P. V., Daheron, L., Park, P. J. & Kingston, R. E. A region of the human HOXD cluster that confers polycomb-group responsiveness. Cell 140, 99-110 (2010).
-
(2010)
Cell
, vol.140
, pp. 99-110
-
-
Woo, C.J.1
Kharchenko, P.V.2
Daheron, L.3
Park, P.J.4
Kingston, R.E.5
-
64
-
-
33845898866
-
Polycomb recruitment to DNA in vivo by the YY1 REPO domain
-
Wilkinson, F. H., Park, K. & Atchison, M. L. Polycomb recruitment to DNA in vivo by the YY1 REPO domain. Proc. Natl Acad. Sci. USA 103, 19296-19301 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 19296-19301
-
-
Wilkinson, F.H.1
Park, K.2
Atchison, M.L.3
-
65
-
-
34250364559
-
Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1
-
Xi, H. et al. Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1. Genome Res. 17, 798-806 (2007).
-
(2007)
Genome Res.
, vol.17
, pp. 798-806
-
-
Xi, H.1
-
66
-
-
0242668706
-
Role of histone H3 lysine 27 methylation in X inactivation
-
Plath, K. et al. Role of histone H3 lysine 27 methylation in X inactivation. Science 300, 131-135 (2003).
-
(2003)
Science
, vol.300
, pp. 131-135
-
-
Plath, K.1
-
67
-
-
75749124997
-
2-D structure of the A region of Xist RNA and its implication for PRC2 association
-
Maenner, S. et al. 2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol. 8, E1000276 (2010).
-
(2010)
PLoS Biol.
, vol.8
-
-
Maenner, S.1
-
68
-
-
55349109963
-
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
-
Zhao, J., Sun, B. K., Erwin, J. A., Song, J. J. & Lee, J. T. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322, 750-756 (2008).
-
(2008)
Science
, vol.322
, pp. 750-756
-
-
Zhao, J.1
Sun, B.K.2
Erwin, J.A.3
Song, J.J.4
Lee, J.T.5
-
69
-
-
19344375746
-
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation
-
Kohlmaier, A. et al. A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol. 2, E171 (2004).
-
(2004)
PLoS Biol.
, vol.2
-
-
Kohlmaier, A.1
-
70
-
-
54049138948
-
Kcnq1ot1 antisense noncoding RNA mediates lineagespecific transcriptional silencing through chromatin-level regulation
-
Pandey, R. R. et al. Kcnq1ot1 antisense noncoding RNA mediates lineagespecific transcriptional silencing through chromatin-level regulation. Mol. Cell 32, 232-246 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 232-246
-
-
Pandey, R.R.1
-
71
-
-
34250729138
-
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
-
Rinn, J. L. et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129, 1311-1323 (2007).
-
(2007)
Cell
, vol.129
, pp. 1311-1323
-
-
Rinn, J.L.1
-
72
-
-
77954572735
-
Long noncoding RNA as modular scaffold of histone modification complexes
-
Tsai, M. C. et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 329, 689-693 (2010).
-
(2010)
Science
, vol.329
, pp. 689-693
-
-
Tsai, M.C.1
-
73
-
-
67650921949
-
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
-
Khalil, A. M. et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc. Natl Acad. Sci. USA 106, 11667-11672 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 11667-11672
-
-
Khalil, A.M.1
-
74
-
-
44149123117
-
Structural basis of histone H4 recognition by p55
-
Song, J. J., Garlick, J. D. & Kingston, R. E. Structural basis of histone H4 recognition by p55. Genes Dev. 22, 1313-1318 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 1313-1318
-
-
Song, J.J.1
Garlick, J.D.2
Kingston, R.E.3
-
75
-
-
70349952171
-
Role of the polycomb protein EED in the propagation of repressive histone marks
-
Margueron, R. et al. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461, 762-767 (2009). This paper reports that PRC2 function is regulated by the mark it deposits, Thus providing a potential mechanism for the spreading of this mark.
-
(2009)
Nature
, vol.461
, pp. 762-767
-
-
Margueron, R.1
-
76
-
-
78149285100
-
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
-
Chen, S. et al. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nature Cell Biol. 12, 1108-1114 (2010).
-
(2010)
Nature Cell Biol.
, vol.12
, pp. 1108-1114
-
-
Chen, S.1
-
77
-
-
78649807567
-
Phosphorylation of the PRC2 component Ezh2 is cell cycleregulated and upregulates its binding to HOTAIR ncRNA
-
Kaneko, S. et al. Phosphorylation of the PRC2 component Ezh2 is cell cycleregulated and upregulates its binding to HOTAIR ncRNA. Genes Dev. 24, 2615-2620 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 2615-2620
-
-
Kaneko, S.1
-
78
-
-
77953096072
-
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
-
Yap, K. L. et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol. Cell 38, 662-674 (2010). In this paper, The authors suggested that ncRNA and H3K27me3 can work together to contribute to PRC1 recruitment.
-
(2010)
Mol. Cell
, vol.38
, pp. 662-674
-
-
Yap, K.L.1
-
79
-
-
63049138876
-
Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro
-
Francis, N. J., Follmer, N. E., Simon, M. D., Aghia, G. & Butler, J. D. Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro. Cell 137, 110-122 (2009).
-
(2009)
Cell
, vol.137
, pp. 110-122
-
-
Francis, N.J.1
Follmer, N.E.2
Simon, M.D.3
Aghia, G.4
Butler, J.D.5
-
80
-
-
55549103314
-
A model for transmission of the H3K27me3 epigenetic mark
-
Hansen, K. H. et al. A model for transmission of the H3K27me3 epigenetic mark. Nature Cell Biol. 10, 1291-1300 (2008).
-
(2008)
Nature Cell Biol.
, vol.10
, pp. 1291-1300
-
-
Hansen, K.H.1
-
81
-
-
48649091905
-
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency
-
Chamberlain, S. J., Yee, D. & Magnuson, T. Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency. Stem Cells 26, 1496-1505 (2008).
-
(2008)
Stem Cells
, vol.26
, pp. 1496-1505
-
-
Chamberlain, S.J.1
Yee, D.2
Magnuson, T.3
-
82
-
-
65549161255
-
The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. Elegans embryos
-
Yuzyuk, T., Fakhouri, T. H., Kiefer, J. & Mango, S. E. The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. Elegans embryos. Dev. Cell 16, 699-710 (2009).
-
(2009)
Dev. Cell
, vol.16
, pp. 699-710
-
-
Yuzyuk, T.1
Fakhouri, T.H.2
Kiefer, J.3
Mango, S.E.4
-
83
-
-
44449104974
-
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity
-
Endoh, M. et al. Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. Development 135, 1513-1524 (2008).
-
(2008)
Development
, vol.135
, pp. 1513-1524
-
-
Endoh, M.1
-
84
-
-
0037320925
-
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
-
Su, I. H. et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nature Immunol. 4, 124-131 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 124-131
-
-
Su, I.H.1
-
85
-
-
77952208495
-
Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis
-
Wang, L., Jin, Q., Lee, J. E., Su, I. H. & Ge, K. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc. Natl Acad. Sci. USA 107, 7317-7322 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 7317-7322
-
-
Wang, L.1
Jin, Q.2
Lee, J.E.3
Su, I.H.4
Ge, K.5
-
86
-
-
7544230144
-
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation
-
Caretti, G., Di Padova, M., Micales, B., Lyons, G. E. & Sartorelli, V. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 18, 2627-2638 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 2627-2638
-
-
Caretti, G.1
Di Padova, M.2
Micales, B.3
Lyons, G.E.4
Sartorelli, V.5
-
87
-
-
62149122634
-
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
-
Ezhkova, E. et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136, 1122-1135 (2009).
-
(2009)
Cell
, vol.136
, pp. 1122-1135
-
-
Ezhkova, E.1
-
88
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally, S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624-629 (2002).
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
-
89
-
-
0141816752
-
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
-
Kleer, C. G. et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl Acad. Sci. USA 100, 11606-11611 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 11606-11611
-
-
Kleer, C.G.1
-
90
-
-
70349515386
-
Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line
-
Karanikolas, B. D., Figueiredo, M. L. & Wu, L. Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line. Mol. Cancer Res. 7, 1456-1465 (2009).
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 1456-1465
-
-
Karanikolas, B.D.1
Figueiredo, M.L.2
Wu, L.3
-
91
-
-
70349238717
-
Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia
-
Li, X. et al. Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia. Am. J. Pathol. 175, 1246-1254 (2009).
-
(2009)
Am. J. Pathol.
, vol.175
, pp. 1246-1254
-
-
Li, X.1
-
92
-
-
0142105414
-
EZH2 is downstream of the pRB-E2F pathway Essential for proliferation and amplified in cancer
-
Bracken, A. P. et al. EZH2 is downstream of the pRB-E2F pathway, Essential for proliferation and amplified in cancer. EMBO J. 22, 5323-5335 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 5323-5335
-
-
Bracken, A.P.1
-
93
-
-
33947134834
-
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
-
Bracken, A. P. et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 21, 525-530 (2007).
-
(2007)
Genes Dev.
, vol.21
, pp. 525-530
-
-
Bracken, A.P.1
-
94
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
Morin, R. D. et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nature Genet. 42, 181-185 (2010). This study is the first report that somatic mutations resulting in the inactivation of PRC2 are found in diseases.
-
(2010)
Nature Genet.
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
-
95
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst, T. et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nature Genet. 42, 722-726 (2010).
-
(2010)
Nature Genet.
, vol.42
, pp. 722-726
-
-
Ernst, T.1
-
96
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
Nikoloski, G. et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nature Genet. 42, 665-667 (2010).
-
(2010)
Natured Genet.
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
-
97
-
-
77950874502
-
Comprehensive evaluation of the role of EZH2 in the growth Invasion, and aggression of a panel of prostate cancer cell lines
-
Karanikolas, B. D., Figueiredo, M. L. & Wu, L. Comprehensive evaluation of the role of EZH2 in the growth, Invasion, And aggression of a panel of prostate cancer cell lines. Prostate 70, 675-688 (2010).
-
(2010)
Prostate
, vol.70
, pp. 675-688
-
-
Karanikolas, B.D.1
Figueiredo, M.L.2
Wu, L.3
-
98
-
-
77953086963
-
ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency
-
Pereira, C. F., Piccolo, F. M., Tsubouchi, T., Sauer, S. & Ryan, N. ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell 6, 547-556 (2010).
-
(2010)
Cell Stem Cell
, vol.6
, pp. 547-556
-
-
Pereira, C.F.1
Piccolo, F.M.2
Tsubouchi, T.3
Sauer, S.4
Ryan, N.5
|