Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization

Cell

Volumn 169, Issue 5, 2017, Pages 930-944.e22

  Nora, Elphège P ^a,b   Goloborodko, Anton ^c   Valton, Anne Laure ^d   Gibcus, Johan H ^d   Uebersohn, Alec ^a,b,g   Abdennur, Nezar ^c   Dekker, Job ^d   Mirny, Leonid A ^c   Bruneau, Benoit G ^a,b,e,f  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b Roddenberry Center for Stem Cell Biology and Medicine at Gladstone   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUXIN; COHESIN; F BOX PROTEIN; TRANSCRIPTION FACTOR CTCF; CCCTC-BINDING FACTOR; CHROMATIN; INDOLEACETIC ACID DERIVATIVE; REPRESSOR PROTEIN;

ALLELE; ANEUPLOIDY; ARTICLE; ASTROCYTE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SPREADING; CELL SURVIVAL; CHROMATIN; CHROMOSOME; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; ENHANCER REGION; GENE ACTIVITY; GENOME ANALYSIS; GENOMICS; HEK293 CELL LINE; HETEROCHROMATIN; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN MISFOLDING; PROTEIN TARGETING; RICE; RNA SEQUENCE; STOP CODON; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ANIMAL; CELL CYCLE; CHEMISTRY; EMBRYONIC STEM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE;

ANIMALS; CELL CYCLE; CHROMATIN; CHROMOSOMES, MAMMALIAN; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; INDOLEACETIC ACIDS; MICE; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 85019568830     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.05.004     Document Type: Article

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