메뉴 건너뛰기




Volumn 167, Issue 5, 2016, Pages 1188-1200

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control

Author keywords

[No Author keywords available]

Indexed keywords

AUTOSOME; CHROMOSOME STRUCTURE; DNA METHYLATION; DNA RECOMBINATION; ENHANCER REGION; EPIGENETICS; GENE ACTIVATION; GENE CONTROL; GENE INTERACTION; GENE REPRESSION; GENETIC ASSOCIATION; GENETIC CONSERVATION; MAMMALIAN GENETICS; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; ANIMAL; CHROMOSOME; GENE EXPRESSION REGULATION; HUMAN; INSULATOR ELEMENT; MAMMAL; METABOLISM;

EID: 84995810181     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.10.024     Document Type: Review
Times cited : (310)

References (105)
  • 1
    • 84988592852 scopus 로고    scopus 로고
    • Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing
    • Amabile, A., Migliara, A., Capasso, P., Biffi, M., Cittaro, D., Naldini, L., Lombardo, A., Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing. Cell 167 (2016), 219–232.
    • (2016) Cell , vol.167 , pp. 219-232
    • Amabile, A.1    Migliara, A.2    Capasso, P.3    Biffi, M.4    Cittaro, D.5    Naldini, L.6    Lombardo, A.7
  • 2
    • 0019811465 scopus 로고
    • Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences
    • Banerji, J., Rusconi, S., Schaffner, W., Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell 27 (1981), 299–308.
    • (1981) Cell , vol.27 , pp. 299-308
    • Banerji, J.1    Rusconi, S.2    Schaffner, W.3
  • 3
    • 0034713375 scopus 로고    scopus 로고
    • Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
    • Bell, A.C., Felsenfeld, G., Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405 (2000), 482–485.
    • (2000) Nature , vol.405 , pp. 482-485
    • Bell, A.C.1    Felsenfeld, G.2
  • 4
    • 0033529654 scopus 로고    scopus 로고
    • The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
    • Bell, A.C., West, A.G., Felsenfeld, G., The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell 98 (1999), 387–396.
    • (1999) Cell , vol.98 , pp. 387-396
    • Bell, A.C.1    West, A.G.2    Felsenfeld, G.3
  • 5
    • 33747174553 scopus 로고    scopus 로고
    • Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for beta-globin transcription
    • Bender, M.A., Byron, R., Ragoczy, T., Telling, A., Bulger, M., Groudine, M., Flanking HS-62.5 and 3′ HS1, and regions upstream of the LCR, are not required for beta-globin transcription. Blood 108 (2006), 1395–1401.
    • (2006) Blood , vol.108 , pp. 1395-1401
    • Bender, M.A.1    Byron, R.2    Ragoczy, T.3    Telling, A.4    Bulger, M.5    Groudine, M.6
  • 6
    • 0019420927 scopus 로고
    • In vivo sequence requirements of the SV40 early promotor region
    • Benoist, C., Chambon, P., In vivo sequence requirements of the SV40 early promotor region. Nature 290 (1981), 304–310.
    • (1981) Nature , vol.290 , pp. 304-310
    • Benoist, C.1    Chambon, P.2
  • 7
    • 84875190221 scopus 로고    scopus 로고
    • Genome architecture: domain organization of interphase chromosomes
    • Bickmore, W.A., van Steensel, B., Genome architecture: domain organization of interphase chromosomes. Cell 152 (2013), 1270–1284.
    • (2013) Cell , vol.152 , pp. 1270-1284
    • Bickmore, W.A.1    van Steensel, B.2
  • 8
    • 0001169778 scopus 로고
    • Die Blastomerenkerne von Ascaris megalocephala und die Theorie der Chromosomenindividualität
    • Boveri, T., Die Blastomerenkerne von Ascaris megalocephala und die Theorie der Chromosomenindividualität. Arch Zellforsch, 1909, 181–268.
    • (1909) Arch Zellforsch , pp. 181-268
    • Boveri, T.1
  • 9
    • 84861529303 scopus 로고    scopus 로고
    • Enhancers as information integration hubs in development: lessons from genomics
    • Buecker, C., Wysocka, J., Enhancers as information integration hubs in development: lessons from genomics. Trends Genet. 28 (2012), 276–284.
    • (2012) Trends Genet. , vol.28 , pp. 276-284
    • Buecker, C.1    Wysocka, J.2
  • 10
    • 79551655285 scopus 로고    scopus 로고
    • Functional and mechanistic diversity of distal transcription enhancers
    • Bulger, M., Groudine, M., Functional and mechanistic diversity of distal transcription enhancers. Cell 144 (2011), 327–339.
    • (2011) Cell , vol.144 , pp. 327-339
    • Bulger, M.1    Groudine, M.2
  • 11
    • 84990998423 scopus 로고    scopus 로고
    • Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region
    • Bunting, K.L., Soong, T.D., Singh, R., Jiang, Y., Béguelin, W., Poloway, D.W., Swed, B.L., Hatzi, K., Reisacher, W., Teater, M., et al. Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region. Immunity 45 (2016), 497–512.
    • (2016) Immunity , vol.45 , pp. 497-512
    • Bunting, K.L.1    Soong, T.D.2    Singh, R.3    Jiang, Y.4    Béguelin, W.5    Poloway, D.W.6    Swed, B.L.7    Hatzi, K.8    Reisacher, W.9    Teater, M.10
  • 12
    • 0035477093 scopus 로고    scopus 로고
    • Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs
    • Butler, J.E., Kadonaga, J.T., Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs. Genes Dev. 15 (2001), 2515–2519.
    • (2001) Genes Dev. , vol.15 , pp. 2515-2519
    • Butler, J.E.1    Kadonaga, J.T.2
  • 13
    • 84875200698 scopus 로고    scopus 로고
    • Functional implications of genome topology
    • Cavalli, G., Misteli, T., Functional implications of genome topology. Nat. Struct. Mol. Biol. 20 (2013), 290–299.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 290-299
    • Cavalli, G.1    Misteli, T.2
  • 14
    • 84857781464 scopus 로고    scopus 로고
    • Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization
    • Chepelev, I., Wei, G., Wangsa, D., Tang, Q., Zhao, K., Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization. Cell Res. 22 (2012), 490–503.
    • (2012) Cell Res. , vol.22 , pp. 490-503
    • Chepelev, I.1    Wei, G.2    Wangsa, D.3    Tang, Q.4    Zhao, K.5
  • 15
    • 0024280908 scopus 로고
    • Developmental regulation of beta-globin gene switching
    • Choi, O.R., Engel, J.D., Developmental regulation of beta-globin gene switching. Cell 55 (1988), 17–26.
    • (1988) Cell , vol.55 , pp. 17-26
    • Choi, O.R.1    Engel, J.D.2
  • 16
    • 0027254748 scopus 로고
    • A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
    • Chung, J.H., Whiteley, M., Felsenfeld, G., A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74 (1993), 505–514.
    • (1993) Cell , vol.74 , pp. 505-514
    • Chung, J.H.1    Whiteley, M.2    Felsenfeld, G.3
  • 17
    • 84954287651 scopus 로고    scopus 로고
    • FTO Obesity Variant and Adipocyte Browning in Humans
    • Claussnitzer, M., Hui, C.C., Kellis, M., FTO Obesity Variant and Adipocyte Browning in Humans. N. Engl. J. Med. 374 (2016), 192–193.
    • (2016) N. Engl. J. Med. , vol.374 , pp. 192-193
    • Claussnitzer, M.1    Hui, C.C.2    Kellis, M.3
  • 18
    • 57849109058 scopus 로고    scopus 로고
    • Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
    • Core, L.J., Waterfall, J.J., Lis, J.T., Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322 (2008), 1845–1848.
    • (2008) Science , vol.322 , pp. 1845-1848
    • Core, L.J.1    Waterfall, J.J.2    Lis, J.T.3
  • 20
    • 84886853624 scopus 로고    scopus 로고
    • Topology of mammalian developmental enhancers and their regulatory landscapes
    • de Laat, W., Duboule, D., Topology of mammalian developmental enhancers and their regulatory landscapes. Nature 502 (2013), 499–506.
    • (2013) Nature , vol.502 , pp. 499-506
    • de Laat, W.1    Duboule, D.2
  • 22
    • 84943358862 scopus 로고    scopus 로고
    • Structural and functional diversity of Topologically Associating Domains
    • Dekker, J., Heard, E., Structural and functional diversity of Topologically Associating Domains. FEBS Lett. 589:20 Pt A (2015), 2877–2884.
    • (2015) FEBS Lett. , vol.589 , Issue.20 , pp. 2877-2884
    • Dekker, J.1    Heard, E.2
  • 23
    • 84960334782 scopus 로고    scopus 로고
    • The 3D Genome as Moderator of Chromosomal Communication
    • Dekker, J., Mirny, L., The 3D Genome as Moderator of Chromosomal Communication. Cell 164 (2016), 1110–1121.
    • (2016) Cell , vol.164 , pp. 1110-1121
    • Dekker, J.1    Mirny, L.2
  • 25
    • 84861095603 scopus 로고    scopus 로고
    • Topological domains in mammalian genomes identified by analysis of chromatin interactions
    • Dixon, J.R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J.S., Ren, B., Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature 485 (2012), 376–380.
    • (2012) Nature , vol.485 , pp. 376-380
    • Dixon, J.R.1    Selvaraj, S.2    Yue, F.3    Kim, A.4    Li, Y.5    Shen, Y.6    Hu, M.7    Liu, J.S.8    Ren, B.9
  • 30
    • 84908333387 scopus 로고    scopus 로고
    • Chromatin loops as allosteric modulators of enhancer-promoter interactions
    • Doyle, B., Fudenberg, G., Imakaev, M., Mirny, L.A., Chromatin loops as allosteric modulators of enhancer-promoter interactions. PLoS Comput. Biol., 10, 2014, e1003867.
    • (2014) PLoS Comput. Biol. , vol.10 , pp. e1003867
    • Doyle, B.1    Fudenberg, G.2    Imakaev, M.3    Mirny, L.A.4
  • 31
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489 (2012), 57–74.
    • (2012) Nature , vol.489 , pp. 57-74
  • 35
    • 84907584433 scopus 로고    scopus 로고
    • Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus
    • Fogarty, M.P., Cannon, M.E., Vadlamudi, S., Gaulton, K.J., Mohlke, K.L., Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus. PLoS Genet., 10, 2014, e1004633.
    • (2014) PLoS Genet. , vol.10 , pp. e1004633
    • Fogarty, M.P.1    Cannon, M.E.2    Vadlamudi, S.3    Gaulton, K.J.4    Mohlke, K.L.5
  • 36
    • 9444244427 scopus 로고    scopus 로고
    • Chromatin compaction by a polycomb group protein complex
    • Francis, N.J., Kingston, R.E., Woodcock, C.L., Chromatin compaction by a polycomb group protein complex. Science 306 (2004), 1574–1577.
    • (2004) Science , vol.306 , pp. 1574-1577
    • Francis, N.J.1    Kingston, R.E.2    Woodcock, C.L.3
  • 38
    • 84978401505 scopus 로고    scopus 로고
    • Enhancer Control of Transcriptional Bursting
    • Fukaya, T., Lim, B., Levine, M., Enhancer Control of Transcriptional Bursting. Cell 166 (2016), 358–368.
    • (2016) Cell , vol.166 , pp. 358-368
    • Fukaya, T.1    Lim, B.2    Levine, M.3
  • 40
    • 0026738877 scopus 로고
    • DNA position-specific repression of transcription by a Drosophila zinc finger protein
    • Geyer, P.K., Corces, V.G., DNA position-specific repression of transcription by a Drosophila zinc finger protein. Genes Dev. 6 (1992), 1865–1873.
    • (1992) Genes Dev. , vol.6 , pp. 1865-1873
    • Geyer, P.K.1    Corces, V.G.2
  • 41
    • 84876838711 scopus 로고    scopus 로고
    • The hierarchy of the 3D genome
    • Gibcus, J.H., Dekker, J., The hierarchy of the 3D genome. Mol. Cell 49 (2013), 773–782.
    • (2013) Mol. Cell , vol.49 , pp. 773-782
    • Gibcus, J.H.1    Dekker, J.2
  • 42
    • 84900297485 scopus 로고    scopus 로고
    • Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription
    • Giorgetti, L., Galupa, R., Nora, E.P., Piolot, T., Lam, F., Dekker, J., Tiana, G., Heard, E., Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell 157 (2014), 950–963.
    • (2014) Cell , vol.157 , pp. 950-963
    • Giorgetti, L.1    Galupa, R.2    Nora, E.P.3    Piolot, T.4    Lam, F.5    Dekker, J.6    Tiana, G.7    Heard, E.8
  • 44
    • 84902212007 scopus 로고    scopus 로고
    • The 3D genome in transcriptional regulation and pluripotency
    • Gorkin, D.U., Leung, D., Ren, B., The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell 14 (2014), 762–775.
    • (2014) Cell Stem Cell , vol.14 , pp. 762-775
    • Gorkin, D.U.1    Leung, D.2    Ren, B.3
  • 47
    • 0019469665 scopus 로고
    • Simian virus 40 tandem repeated sequences as an element of the early promoter
    • Gruss, P., Dhar, R., Khoury, G., Simian virus 40 tandem repeated sequences as an element of the early promoter. Proc. Natl. Acad. Sci. USA 78 (1981), 943–947.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 943-947
    • Gruss, P.1    Dhar, R.2    Khoury, G.3
  • 48
    • 84929001104 scopus 로고    scopus 로고
    • Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
    • GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348 (2015), 648–660.
    • (2015) Science , vol.348 , pp. 648-660
  • 49
    • 84939246295 scopus 로고    scopus 로고
    • CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function
    • Guo, Y., Xu, Q., Canzio, D., Shou, J., Li, J., Gorkin, D.U., Jung, I., Wu, H., Zhai, Y., Tang, Y., et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell 162 (2015), 900–910.
    • (2015) Cell , vol.162 , pp. 900-910
    • Guo, Y.1    Xu, Q.2    Canzio, D.3    Shou, J.4    Li, J.5    Gorkin, D.U.6    Jung, I.7    Wu, H.8    Zhai, Y.9    Tang, Y.10
  • 51
    • 0034713275 scopus 로고    scopus 로고
    • CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
    • Hark, A.T., Schoenherr, C.J., Katz, D.J., Ingram, R.S., Levorse, J.M., Tilghman, S.M., CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405 (2000), 486–489.
    • (2000) Nature , vol.405 , pp. 486-489
    • Hark, A.T.1    Schoenherr, C.J.2    Katz, D.J.3    Ingram, R.S.4    Levorse, J.M.5    Tilghman, S.M.6
  • 52
    • 57149108265 scopus 로고    scopus 로고
    • Chromosome alignment and transvection are antagonized by condensin II
    • Hartl, T.A., Smith, H.F., Bosco, G., Chromosome alignment and transvection are antagonized by condensin II. Science 322 (2008), 1384–1387.
    • (2008) Science , vol.322 , pp. 1384-1387
    • Hartl, T.A.1    Smith, H.F.2    Bosco, G.3
  • 57
    • 58149498240 scopus 로고    scopus 로고
    • CTCF-dependent enhancer-blocking by alternative chromatin loop formation
    • Hou, C., Zhao, H., Tanimoto, K., Dean, A., CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc. Natl. Acad. Sci. USA 105 (2008), 20398–20403.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 20398-20403
    • Hou, C.1    Zhao, H.2    Tanimoto, K.3    Dean, A.4
  • 61
    • 0034644120 scopus 로고    scopus 로고
    • Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
    • Kanduri, C., Pant, V., Loukinov, D., Pugacheva, E., Qi, C.F., Wolffe, A., Ohlsson, R., Lobanenkov, V.V., Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr. Biol. 10 (2000), 853–856.
    • (2000) Curr. Biol. , vol.10 , pp. 853-856
    • Kanduri, C.1    Pant, V.2    Loukinov, D.3    Pugacheva, E.4    Qi, C.F.5    Wolffe, A.6    Ohlsson, R.7    Lobanenkov, V.V.8
  • 63
    • 0026027982 scopus 로고
    • A position-effect assay for boundaries of higher order chromosomal domains
    • Kellum, R., Schedl, P., A position-effect assay for boundaries of higher order chromosomal domains. Cell 64 (1991), 941–950.
    • (1991) Cell , vol.64 , pp. 941-950
    • Kellum, R.1    Schedl, P.2
  • 65
    • 33746063711 scopus 로고    scopus 로고
    • CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    • Kurukuti, S., Tiwari, V.K., Tavoosidana, G., Pugacheva, E., Murrell, A., Zhao, Z., Lobanenkov, V., Reik, W., Ohlsson, R., CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc. Natl. Acad. Sci. USA 103 (2006), 10684–10689.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 10684-10689
    • Kurukuti, S.1    Tiwari, V.K.2    Tavoosidana, G.3    Pugacheva, E.4    Murrell, A.5    Zhao, Z.6    Lobanenkov, V.7    Reik, W.8    Ohlsson, R.9
  • 67
    • 84897138228 scopus 로고    scopus 로고
    • Looping back to leap forward: transcription enters a new era
    • Levine, M., Cattoglio, C., Tjian, R., Looping back to leap forward: transcription enters a new era. Cell 157 (2014), 13–25.
    • (2014) Cell , vol.157 , pp. 13-25
    • Levine, M.1    Cattoglio, C.2    Tjian, R.3
  • 73
    • 84984905591 scopus 로고    scopus 로고
    • CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation
    • Merkenschlager, M., Nora, E.P., CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation. Annu. Rev. Genomics Hum. Genet. 17 (2016), 17–43.
    • (2016) Annu. Rev. Genomics Hum. Genet. , vol.17 , pp. 17-43
    • Merkenschlager, M.1    Nora, E.P.2
  • 74
    • 3543018516 scopus 로고    scopus 로고
    • Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
    • Murrell, A., Heeson, S., Reik, W., Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nat. Genet. 36 (2004), 889–893.
    • (2004) Nat. Genet. , vol.36 , pp. 889-893
    • Murrell, A.1    Heeson, S.2    Reik, W.3
  • 75
    • 84923771297 scopus 로고    scopus 로고
    • CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation
    • Narendra, V., Rocha, P.P., An, D., Raviram, R., Skok, J.A., Mazzoni, E.O., Reinberg, D., CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation. Science 347 (2015), 1017–1021.
    • (2015) Science , vol.347 , pp. 1017-1021
    • Narendra, V.1    Rocha, P.P.2    An, D.3    Raviram, R.4    Skok, J.A.5    Mazzoni, E.O.6    Reinberg, D.7
  • 76
    • 79952605614 scopus 로고    scopus 로고
    • Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome
    • Nativio, R., Sparago, A., Ito, Y., Weksberg, R., Riccio, A., Murrell, A., Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome. Hum. Mol. Genet. 20 (2011), 1363–1374.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1363-1374
    • Nativio, R.1    Sparago, A.2    Ito, Y.3    Weksberg, R.4    Riccio, A.5    Murrell, A.6
  • 78
    • 0032519586 scopus 로고    scopus 로고
    • Different core promoters possess distinct regulatory activities in the Drosophila embryo
    • Ohtsuki, S., Levine, M., Cai, H.N., Different core promoters possess distinct regulatory activities in the Drosophila embryo. Genes Dev. 12 (1998), 547–556.
    • (1998) Genes Dev. , vol.12 , pp. 547-556
    • Ohtsuki, S.1    Levine, M.2    Cai, H.N.3
  • 79
    • 79952901680 scopus 로고    scopus 로고
    • Enhancer function: new insights into the regulation of tissue-specific gene expression
    • Ong, C.T., Corces, V.G., Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat. Rev. Genet. 12 (2011), 283–293.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 283-293
    • Ong, C.T.1    Corces, V.G.2
  • 80
    • 84899415536 scopus 로고    scopus 로고
    • CTCF: an architectural protein bridging genome topology and function
    • Ong, C.T., Corces, V.G., CTCF: an architectural protein bridging genome topology and function. Nat. Rev. Genet. 15 (2014), 234–246.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 234-246
    • Ong, C.T.1    Corces, V.G.2
  • 81
    • 84884840336 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila
    • Ong, C.T., Van Bortle, K., Ramos, E., Corces, V.G., Poly(ADP-ribosyl)ation regulates insulator function and intrachromosomal interactions in Drosophila. Cell 155 (2013), 148–159.
    • (2013) Cell , vol.155 , pp. 148-159
    • Ong, C.T.1    Van Bortle, K.2    Ramos, E.3    Corces, V.G.4
  • 82
    • 67549119096 scopus 로고    scopus 로고
    • CTCF: master weaver of the genome
    • Phillips, J.E., Corces, V.G., CTCF: master weaver of the genome. Cell 137 (2009), 1194–1211.
    • (2009) Cell , vol.137 , pp. 1194-1211
    • Phillips, J.E.1    Corces, V.G.2
  • 83
    • 84878188440 scopus 로고    scopus 로고
    • Chromatin insulators: linking genome organization to cellular function
    • Phillips-Cremins, J.E., Corces, V.G., Chromatin insulators: linking genome organization to cellular function. Mol. Cell 50 (2013), 461–474.
    • (2013) Mol. Cell , vol.50 , pp. 461-474
    • Phillips-Cremins, J.E.1    Corces, V.G.2
  • 87
    • 84978776432 scopus 로고    scopus 로고
    • Transcriptional enhancers: bridging the genome and phenome
    • Ren, B., Yue, F., Transcriptional enhancers: bridging the genome and phenome. Cold Spring Harb. Symp. Quant. Biol. 80 (2015), 17–26.
    • (2015) Cold Spring Harb. Symp. Quant. Biol. , vol.80 , pp. 17-26
    • Ren, B.1    Yue, F.2
  • 90
    • 84984804790 scopus 로고    scopus 로고
    • Genome-wide mapping and analysis of chromosome architecture
    • Published online September 1, 2016
    • Schmitt, A.D., Hu, M., Ren, B., Genome-wide mapping and analysis of chromosome architecture. Nat. Rev. Mol. Cell Biol., 2016, 10.1038/nrm.2016.104 Published online September 1, 2016.
    • (2016) Nat. Rev. Mol. Cell Biol.
    • Schmitt, A.D.1    Hu, M.2    Ren, B.3
  • 93
    • 84954288250 scopus 로고    scopus 로고
    • Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus
    • Smith, E.M., Lajoie, B.R., Jain, G., Dekker, J., Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus. Am. J. Hum. Genet. 98 (2016), 185–201.
    • (2016) Am. J. Hum. Genet. , vol.98 , pp. 185-201
    • Smith, E.M.1    Lajoie, B.R.2    Jain, G.3    Dekker, J.4
  • 94
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: from enhancer binding to developmental control
    • Spitz, F., Furlong, E.E., Transcription factors: from enhancer binding to developmental control. Nat. Rev. Genet. 13 (2012), 613–626.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.2
  • 95
    • 33748259774 scopus 로고    scopus 로고
    • CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus
    • Splinter, E., Heath, H., Kooren, J., Palstra, R.J., Klous, P., Grosveld, F., Galjart, N., de Laat, W., CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev. 20 (2006), 2349–2354.
    • (2006) Genes Dev. , vol.20 , pp. 2349-2354
    • Splinter, E.1    Heath, H.2    Kooren, J.3    Palstra, R.J.4    Klous, P.5    Grosveld, F.6    Galjart, N.7    de Laat, W.8
  • 96
    • 0034193691 scopus 로고    scopus 로고
    • Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function
    • Szabó, P., Tang, S.H., Rentsendorj, A., Pfeifer, G.P., Mann, J.R., Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function. Curr. Biol. 10 (2000), 607–610.
    • (2000) Curr. Biol. , vol.10 , pp. 607-610
    • Szabó, P.1    Tang, S.H.2    Rentsendorj, A.3    Pfeifer, G.P.4    Mann, J.R.5
  • 98
    • 0028337542 scopus 로고
    • Transcriptional activation: a complex puzzle with few easy pieces
    • Tjian, R., Maniatis, T., Transcriptional activation: a complex puzzle with few easy pieces. Cell 77 (1994), 5–8.
    • (1994) Cell , vol.77 , pp. 5-8
    • Tjian, R.1    Maniatis, T.2
  • 99
    • 0036923833 scopus 로고    scopus 로고
    • Looping and interaction between hypersensitive sites in the active beta-globin locus
    • Tolhuis, B., Palstra, R.J., Splinter, E., Grosveld, F., de Laat, W., Looping and interaction between hypersensitive sites in the active beta-globin locus. Mol. Cell 10 (2002), 1453–1465.
    • (2002) Mol. Cell , vol.10 , pp. 1453-1465
    • Tolhuis, B.1    Palstra, R.J.2    Splinter, E.3    Grosveld, F.4    de Laat, W.5
  • 101
    • 0022178109 scopus 로고
    • The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains
    • Udvardy, A., Maine, E., Schedl, P., The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains. J. Mol. Biol. 185 (1985), 341–358.
    • (1985) J. Mol. Biol. , vol.185 , pp. 341-358
    • Udvardy, A.1    Maine, E.2    Schedl, P.3
  • 102
    • 84924533047 scopus 로고    scopus 로고
    • Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture
    • Vietri Rudan, M., Barrington, C., Henderson, S., Ernst, C., Odom, D.T., Tanay, A., Hadjur, S., Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture. Cell Rep. 10 (2015), 1297–1309.
    • (2015) Cell Rep. , vol.10 , pp. 1297-1309
    • Vietri Rudan, M.1    Barrington, C.2    Henderson, S.3    Ernst, C.4    Odom, D.T.5    Tanay, A.6    Hadjur, S.7
  • 105
    • 84925543087 scopus 로고    scopus 로고
    • Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation
    • Zabidi, M.A., Arnold, C.D., Schernhuber, K., Pagani, M., Rath, M., Frank, O., Stark, A., Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation. Nature 518 (2015), 556–559.
    • (2015) Nature , vol.518 , pp. 556-559
    • Zabidi, M.A.1    Arnold, C.D.2    Schernhuber, K.3    Pagani, M.4    Rath, M.5    Frank, O.6    Stark, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.