PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation

Cell Stem Cell

Volumn 20, Issue 5, 2017, Pages 689-705.e9

  Cruz Molina, Sara ^a   Respuela, Patricia ^a   Tebartz, Christina ^a   Kolovos, Petros ^b   Nikolic, Milos ^a   Fueyo, Raquel ^c   van Ijcken, Wilfred F J ^b   Grosveld, Frank ^b   Frommolt, Peter ^a   Bazzi, Hisham ^a   Rada Iglesias, Alvaro ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

Author keywords

anterior neural; differentiation; enhancers; facilitators; permissive; pluripotency; poised; polycomb; PRC2; topology

Indexed keywords

LHX5 PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR SIX3; TRANSCRIPTION FACTOR SOX1; UNCLASSIFIED DRUG; SUZ12 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CALCIUM CELL LEVEL; CELL DEATH; CELL DIFFERENTIATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME; CONTROLLED STUDY; CPG ISLAND; DEVELOPMENTAL GENE; DOWN REGULATION; EMBRYO; ENDOPLASMIC RETICULUM STRESS; ENHANCER REGION; GENE DELETION; GENE TARGETING; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NEURAL STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; RNA SEQUENCE; TRANSCRIPTION INITIATION SITE; ANIMAL; CELL LINE; CYTOLOGY; EMBRYONIC STEM CELL; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; EMBRYONIC STEM CELLS; FLUORESCENT ANTIBODY TECHNIQUE; MICE; PLURIPOTENT STEM CELLS; POLYCOMB REPRESSIVE COMPLEX 2; POLYMERASE CHAIN REACTION;

EID: 85014581667     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.02.004     Document Type: Article

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