Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci

Science

Volumn 346, Issue 6212, 2014, Pages 1004-1006

  Lonfat, Nicolas ^a,c   Montavon, Thomas ^a,d   Darbellay, Fabrice ^a   Gitto, Sandra ^b   Duboule, Denis ^a,b  

^a EPFL   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; MESSENGER RNA; HOMEOBOX PROTEIN HOXA13; HOMEODOMAIN PROTEIN; HOXA PROTEIN;

CONVERGENT EVOLUTION; GENE; GENOME; MORPHOGENESIS; PHYSIOLOGICAL RESPONSE; PLEIOTROPY; TOPOLOGY; VERTEBRATE;

ANIMAL EXPERIMENT; ARTICLE; CHROMATIN STRUCTURE; CONFORMATIONAL TRANSITION; CONVERGENT EVOLUTION; EMBRYO; ENHANCER REGION; GENE EXPRESSION; GENE LOCUS; GENETIC TRANSCRIPTION; GENOME; HISTONE ACETYLATION; HOX GENE; MOUSE; NONHUMAN; PLEIOTROPY; PROMOTER REGION; REGULATORY MECHANISM; TISSUE SPECIFICITY; UPREGULATION; ANIMAL; CHICK EMBRYO; GENE EXPRESSION REGULATION; GENETICS; GENITAL SYSTEM; GROWTH, DEVELOPMENT AND AGING; HOMEOBOX; HUMAN; LIMB; MOLECULAR EVOLUTION; MORPHOGENESIS; MULTIGENE FAMILY; VERTEBRATE;

ANIMALS; CHICK EMBRYO; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENETIC LOCI; GENETIC PLEIOTROPY; GENITALIA; HOMEODOMAIN PROTEINS; HUMANS; MICE; MORPHOGENESIS; MULTIGENE FAMILY; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; VERTEBRATES;

EID: 84911895715     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1257493     Document Type: Article

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