Reactivation of developmentally silenced globin genes by forced chromatin looping

Cell

Volumn 158, Issue 4, 2014, Pages 849-860

  Deng, Wulan ^a,b   Rupon, Jeremy W ^a   Krivega, Ivan ^c   Breda, Laura ^d   Motta, Irene ^d   Jahn, Kristen S ^a   Reik, Andreas ^e   Gregory, Philip D ^e   Rivella, Stefano ^d   Dean, Ann ^c   Blobel, Gerd A ^a,f  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e SANGAMO BIOSCIENCES INC   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GLOBIN MESSENGER RNA; HEMOGLOBIN F; HEMOGLOBIN GAMMA CHAIN; TRANSCRIPTION FACTOR GATA 1; ZINC FINGER PROTEIN; CHROMATIN; HEMOGLOBIN BETA CHAIN; GLOBIN;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONFORMATION; CONTROLLED STUDY; DEVELOPMENTAL GENE; EMBRYO; ERYTHROID PRECURSOR CELL; FORCED CHROMATIN LOOPING; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GLOBIN GENE; GLOBIN SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS INFECTION; ANIMAL; ANIMAL EMBRYO; CHEMISTRY; ERYTHROBLAST; GENETIC PROCEDURES; GENETICS; HEMOGLOBINOPATHIES; METABOLISM; PRIMARY CELL CULTURE; TRANSCRIPTION INITIATION; ANIMAL CELL; CELL DIFFERENTIATION; EMBRYO DEVELOPMENT; ERYTHROID CELL; GENE SILENCING; GENE TARGETING; IN VITRO STUDY; PROTEIN ASSEMBLY; PROTEIN SYNTHESIS; REDUCTION; WILD TYPE;

ANIMALS; ANTIGENS, CD34; BETA-GLOBINS; CHROMATIN; EMBRYO, MAMMALIAN; ERYTHROBLASTS; FETAL HEMOGLOBIN; GENETIC TECHNIQUES; HEMOGLOBINOPATHIES; HUMANS; LOCUS CONTROL REGION; MICE; PRIMARY CELL CULTURE; TRANSCRIPTIONAL ACTIVATION;

EID: 84908439526     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2014.05.050     Document Type: Article

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