Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

Nature Genetics

Volumn 49, Issue 10, 2017, Pages 1539-1545

  Will, Anja J ^a,b   Cova, Giulia ^a,b   Osterwalder, Marco ^c   Chan, Wing Lee ^a,b   Wittler, Lars ^a   Brieske, Norbert ^a   Heinrich, Verena ^a   De Villartay, Jean Pierre ^d   Vingron, Martin ^a   Klopocki, Eva ^e   Visel, Axel ^c,f,g   Lupianez, Darío G ^a,b   Mundlos, Stefan ^a,b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d IMAGINE INSTITUTE   (France)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f DOE JOINT GENOME INSTITUTE   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SONIC HEDGEHOG PROTEIN; DNA BINDING PROTEIN; IHH PROTEIN, MOUSE; XLF PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; CONTROLLED STUDY; COPY NUMBER VARIATION; DEVELOPMENTAL GENE; DEVELOPMENTAL GENETICS; DIGIT (BODY PART); DNA END JOINING REPAIR; EMBRYO; ENHANCER REGION; EPIPHYSIS PLATE; FINGER; FINGERTIP; FORELIMB; GENE CLUSTER; GENE DELETION; GENE DUPLICATION; GENE EDITING; GENE EXPRESSION REGULATION; GROWTH DISORDER; HEDGEHOG SIGNALING; LONG BONE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHALANX; PRIORITY JOURNAL; SKULL; SKULL DEFECT; SKULL SUTURE; SPATIOTEMPORAL ANALYSIS; SYNDACTYLY; TISSUE SPECIFICITY; UPREGULATION; ABNORMALITIES; ANIMAL; BONE DEVELOPMENT; BONE DYSPLASIA; C57BL MOUSE; DEFICIENCY; DNA SEQUENCE; FOOT MALFORMATION; GENE DOSAGE; GENE INACTIVATION; GENETIC TRANSCRIPTION; GENETICS; PHYSIOLOGY; POLYDACTYLY; REGULATORY SEQUENCE; REPORTER GENE;

ANIMALS; BASE SEQUENCE; BONE DISEASES, DEVELOPMENTAL; DNA COPY NUMBER VARIATIONS; DNA-BINDING PROTEINS; ENHANCER ELEMENTS, GENETIC; FOOT DEFORMITIES, CONGENITAL; GENE DELETION; GENE DOSAGE; GENE DUPLICATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; GENES, REPORTER; HEDGEHOG PROTEINS; MICE; MICE, INBRED C57BL; OSTEOGENESIS; POLYDACTYLY; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS, DNA; SKULL; TRANSCRIPTION, GENETIC;

EID: 85030184273     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3939     Document Type: Article

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