The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances

Developmental Cell

Volumn 39, Issue 5, 2016, Pages 529-543

  Symmons, Orsolya ^a,b   Pan, Leslie ^a   Remeseiro, Silvia ^a   Aktas, Tugce ^a,c,d   Klein, Felix ^a   Huber, Wolfgang ^a   Spitz, François ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d INSTITUT PASTEUR   (France)

Author keywords

chromatin conformation; gene expression; long distance enhancers; Shh; topological domains

Indexed keywords

PROTEIN; RNF32 PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; ZRS PROTEIN; SHH PROTEIN, MOUSE;

ALLELE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; GENE EXPRESSION; GENE LOCUS; GENOMICS; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOPOLOGICALLY ASSOCIATING DOMAIN; UPREGULATION; ANIMAL; C57BL MOUSE; CONGENITAL DISORDER; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; TRANSGENIC MOUSE;

ANIMALS; CONGENITAL ABNORMALITIES; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; HEDGEHOG PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC;

EID: 85000885269     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2016.10.015     Document Type: Article

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