-
1
-
-
85016548232
-
Elements of cancer immunity and the cancer-immune set point
-
28102259,. PMID
-
Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017;541:321-30. doi:10.1038/nature21349. PMID:28102259
-
(2017)
Nature
, vol.541
, pp. 321-330
-
-
Chen, D.S.1
Mellman, I.2
-
2
-
-
84991619059
-
Immunogenic cell death in cancer and infectious disease
-
27748397,. PMID
-
Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2017;17:97-111. doi:10.1038/nri.2016.107. PMID:27748397
-
(2017)
Nat Rev Immunol
, vol.17
, pp. 97-111
-
-
Galluzzi, L.1
Buque, A.2
Kepp, O.3
Zitvogel, L.4
Kroemer, G.5
-
3
-
-
84962896209
-
Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity
-
27141402,. PMID
-
Cheng WC, Ho PC. Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity. Oncoimmunology. 2016;5:e1119355. doi:10.1080/2162402X.2015.1119355. PMID:27141402
-
(2016)
Oncoimmunology
, vol.5
, pp. 1119355
-
-
Cheng, W.C.1
Ho, P.C.2
-
4
-
-
84956607773
-
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents
-
26678337,. PMID
-
Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. Cancer Cell. 2015;28:690-714. doi:10.1016/j.ccell.2015.10.012. PMID:26678337
-
(2015)
Cancer Cell
, vol.28
, pp. 690-714
-
-
Galluzzi, L.1
Buque, A.2
Kepp, O.3
Zitvogel, L.4
Kroemer, G.5
-
5
-
-
84880706152
-
Oncology meets immunology: the cancer-immunity cycle
-
23890059,. PMID
-
Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39:1-10. doi:10.1016/j.immuni.2013.07.012. PMID:23890059
-
(2013)
Immunity
, vol.39
, pp. 1-10
-
-
Chen, D.S.1
Mellman, I.2
-
6
-
-
84960422665
-
The Basis of Oncoimmunology
-
26967289,. PMID
-
Palucka AK, Coussens LM. The Basis of Oncoimmunology. Cell. 2016;164:1233-47. doi:10.1016/j.cell.2016.01.049. PMID:26967289
-
(2016)
Cell
, vol.164
, pp. 1233-1247
-
-
Palucka, A.K.1
Coussens, L.M.2
-
7
-
-
84959440329
-
Tumor infiltration by Tbet+ effector T cells and CD20+ B cells is associated with survival in gastric cancer patients
-
27057426, et al.,. PMID
-
Hennequin A, Derangere V, Boidot R, Apetoh L, Vincent J, Orry D, Fraisse J, Causeret S, Martin F, Arnould L, et al. Tumor infiltration by Tbet+ effector T cells and CD20+ B cells is associated with survival in gastric cancer patients. Oncoimmunology. 2016;5:e1054598. doi:10.1080/2162402X.2015.1054598. PMID:27057426
-
(2016)
Oncoimmunology
, vol.5
, pp. 1054598
-
-
Hennequin, A.1
Derangere, V.2
Boidot, R.3
Apetoh, L.4
Vincent, J.5
Orry, D.6
Fraisse, J.7
Causeret, S.8
Martin, F.9
Arnould, L.10
-
8
-
-
84954481360
-
Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells
-
25949911, et al.,. PMID
-
Sanchez-Martinez D, Azaceta G, Muntasell A, Aguilo N, Nunez D, Galvez EM, Naval J, Anel A, Palomera L, Vilches C, et al. Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells. Oncoimmunology. 2015;4:e991613. doi:10.4161/2162402X.2014.991613. PMID:25949911
-
(2015)
Oncoimmunology
, vol.4
, pp. 991613
-
-
Sanchez-Martinez, D.1
Azaceta, G.2
Muntasell, A.3
Aguilo, N.4
Nunez, D.5
Galvez, E.M.6
Naval, J.7
Anel, A.8
Palomera, L.9
Vilches, C.10
-
9
-
-
85013459761
-
Targeting NK-cell checkpoints for cancer immunotherapy
-
28236750,. PMID
-
Muntasell A, Ochoa MC, Cordeiro L, Berraondo P, Lopez-Diaz de Cerio A, Cabo M, Lopez-Botet M, Melero I. Targeting NK-cell checkpoints for cancer immunotherapy. Curr Opin Immunol. 2017;45:73-81. doi:10.1016/j.coi.2017.01.003. PMID:28236750
-
(2017)
Curr Opin Immunol
, vol.45
, pp. 73-81
-
-
Muntasell, A.1
Ochoa, M.C.2
Cordeiro, L.3
Berraondo, P.4
Lopez-Diaz de Cerio, A.5
Cabo, M.6
Lopez-Botet, M.7
Melero, I.8
-
10
-
-
84968725145
-
Natural Killer Cell-Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future
-
26903071,. PMID
-
Muntasell A, Lopez-Botet M. Natural Killer Cell-Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future. Clin Cancer Res. 2016;22:1831-3. doi:10.1158/1078-0432.CCR-15-3168. PMID:26903071
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1831-1833
-
-
Muntasell, A.1
Lopez-Botet, M.2
-
11
-
-
85029549369
-
Control of metastasis by NK cells
-
28292442,. PMID
-
Lopez-Soto A, Gonzalez S, Smyth MJ, Galluzzi L. Control of metastasis by NK cells. Cancer Cell. 2017;32:135-154. doi:10.1016/j.ccell.2017.06.009. PMID:28292442
-
(2017)
Cancer Cell
, vol.32
, pp. 135-154
-
-
Lopez-Soto, A.1
Gonzalez, S.2
Smyth, M.J.3
Galluzzi, L.4
-
12
-
-
85013073556
-
Involvement of autophagy in NK cell development and function
-
28103115,. PMID
-
Lopez-Soto A, Bravo-San Pedro JM, Kroemer G, Galluzzi L, Gonzalez S. Involvement of autophagy in NK cell development and function. Autophagy. 2017;13:633-6. doi:10.1080/15548627.2016.1274486. PMID:28103115
-
(2017)
Autophagy
, vol.13
, pp. 633-636
-
-
Lopez-Soto, A.1
Bravo-San Pedro, J.M.2
Kroemer, G.3
Galluzzi, L.4
Gonzalez, S.5
-
13
-
-
84997217103
-
Activated Allogeneic NK Cells Preferentially Kill Poor Prognosis B-Cell Chronic Lymphocytic Leukemia Cells
-
27833611, et al.,. PMID
-
Sanchez-Martinez D, Lanuza PM, Gomez N, Muntasell A, Cisneros E, Moraru M, Azaceta G, Anel A, Martinez-Lostao L, Villalba M, et al. Activated Allogeneic NK Cells Preferentially Kill Poor Prognosis B-Cell Chronic Lymphocytic Leukemia Cells. Front Immunol. 2016;7:454. doi:10.3389/fimmu.2016.00454. PMID:27833611
-
(2016)
Front Immunol
, vol.7
, pp. 454
-
-
Sanchez-Martinez, D.1
Lanuza, P.M.2
Gomez, N.3
Muntasell, A.4
Cisneros, E.5
Moraru, M.6
Azaceta, G.7
Anel, A.8
Martinez-Lostao, L.9
Villalba, M.10
-
14
-
-
84937837169
-
Molecular and cellular insights into T cell exhaustion
-
26205583,. PMID
-
Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15:486-99. doi:10.1038/nri3862. PMID:26205583
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 486-499
-
-
Wherry, E.J.1
Kurachi, M.2
-
15
-
-
84875223135
-
Proposed mechanisms of action for prostate cancer vaccines
-
23399727,. PMID
-
Geary SM, Lemke CD, Lubaroff DM, Salem AK. Proposed mechanisms of action for prostate cancer vaccines. Nat Rev Urol. 2013;10:149-60. doi:10.1038/nrurol.2013.8. PMID:23399727
-
(2013)
Nat Rev Urol
, vol.10
, pp. 149-160
-
-
Geary, S.M.1
Lemke, C.D.2
Lubaroff, D.M.3
Salem, A.K.4
-
16
-
-
84929961969
-
Perforin and granzymes: function, dysfunction and human pathology
-
25998963,. PMID
-
Voskoboinik I, Whisstock JC, Trapani JA. Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol. 2015;15:388-400. doi:10.1038/nri3839. PMID:25998963
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 388-400
-
-
Voskoboinik, I.1
Whisstock, J.C.2
Trapani, J.A.3
-
17
-
-
84961666207
-
PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity
-
27141339,. PMID
-
Lim TS, Chew V, Sieow JL, Goh S, Yeong JP, Soon AL, Ricciardi-Castagnoli P. PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity. Oncoimmunology. 2016;5:e1085146. doi:10.1080/2162402X.2015.1085146. PMID:27141339
-
(2016)
Oncoimmunology
, vol.5
, pp. 1085146
-
-
Lim, T.S.1
Chew, V.2
Sieow, J.L.3
Goh, S.4
Yeong, J.P.5
Soon, A.L.6
Ricciardi-Castagnoli, P.7
-
18
-
-
84941787327
-
Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells
-
26985398,. PMID
-
Baleeiro RB, Rietscher R, Diedrich A, Czaplewska JA, Lehr CM, Scherliess R, Hanefeld A, Gottschaldt M, Walden P. Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells. Oncoimmunology. 2015;4:e1047585. doi:10.1080/2162402X.2015.1047585. PMID:26985398
-
(2015)
Oncoimmunology
, vol.4
, pp. 1047585
-
-
Baleeiro, R.B.1
Rietscher, R.2
Diedrich, A.3
Czaplewska, J.A.4
Lehr, C.M.5
Scherliess, R.6
Hanefeld, A.7
Gottschaldt, M.8
Walden, P.9
-
19
-
-
84944463390
-
Restoration of defective cross-presentation in tumors by gemcitabine
-
26155402,. PMID
-
McDonnell AM, Joost Lesterhuis W, Khong A, Nowak AK, Lake RA, Currie AJ, Robinson BW. Restoration of defective cross-presentation in tumors by gemcitabine. Oncoimmunology. 2015;4:e1005501. doi:10.1080/2162402X.2015.1005501. PMID:26155402
-
(2015)
Oncoimmunology
, vol.4
, pp. 1005501
-
-
McDonnell, A.M.1
Joost Lesterhuis, W.2
Khong, A.3
Nowak, A.K.4
Lake, R.A.5
Currie, A.J.6
Robinson, B.W.7
-
20
-
-
85014911516
-
Dying cells actively regulate adaptive immune responses
-
28287107,. PMID
-
Yatim N, Cullen S, Albert ML. Dying cells actively regulate adaptive immune responses. Nat Rev Immunol. 2017;17:262-75. doi:10.1038/nri.2017.9. PMID:28287107
-
(2017)
Nat Rev Immunol
, vol.17
, pp. 262-275
-
-
Yatim, N.1
Cullen, S.2
Albert, M.L.3
-
21
-
-
84875463042
-
Molecular mechanisms of T cell co-stimulation and co-inhibition
-
23470321,. PMID
-
Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013;13:227-42. doi:10.1038/nri3405. PMID:23470321
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 227-242
-
-
Chen, L.1
Flies, D.B.2
-
22
-
-
85016137167
-
Immunological Mechanisms Underneath the Efficacy of Cancer Therapy
-
27803050,. PMID
-
Galluzzi L, Zitvogel L, Kroemer G. Immunological Mechanisms Underneath the Efficacy of Cancer Therapy. Cancer Immunol Res. 2016;4:895-902. doi:10.1158/2326-6066.CIR-16-0197. PMID:27803050
-
(2016)
Cancer Immunol Res
, vol.4
, pp. 895-902
-
-
Galluzzi, L.1
Zitvogel, L.2
Kroemer, G.3
-
23
-
-
80054875478
-
Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease
-
22017435,. PMID
-
Rickert RC, Jellusova J, Miletic AV. Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease. Immunol Rev. 2011;244:115-33. doi:10.1111/j.1600-065X.2011.01067.x. PMID:22017435
-
(2011)
Immunol Rev
, vol.244
, pp. 115-133
-
-
Rickert, R.C.1
Jellusova, J.2
Miletic, A.V.3
-
24
-
-
63149163677
-
The role of TNF superfamily members in T-cell function and diseases
-
19319144,. PMID
-
Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol. 2009;9:271-85. doi:10.1038/nri2526. PMID:19319144
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 271-285
-
-
Croft, M.1
-
25
-
-
84941758827
-
Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
-
26451310, et al.,. PMID
-
Dai H, Zhang W, Li X, Han Q, Guo Y, Zhang Y, Wang Y, Wang C, Shi F, Zhang Y, et al. Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. Oncoimmunology. 2015;4:e1027469. doi:10.1080/2162402X.2015.1027469. PMID:26451310
-
(2015)
Oncoimmunology
, vol.4
, pp. 1027469
-
-
Dai, H.1
Zhang, W.2
Li, X.3
Han, Q.4
Guo, Y.5
Zhang, Y.6
Wang, Y.7
Wang, C.8
Shi, F.9
Zhang, Y.10
-
26
-
-
84893711428
-
Tolerance and exhaustion: defining mechanisms of T cell dysfunction
-
24210163,. PMID
-
Schietinger A, Greenberg PD. Tolerance and exhaustion: defining mechanisms of T cell dysfunction. Trends Immunol. 2014;35:51-60. doi:10.1016/j.it.2013.10.001. PMID:24210163
-
(2014)
Trends Immunol
, vol.35
, pp. 51-60
-
-
Schietinger, A.1
Greenberg, P.D.2
-
27
-
-
84877059916
-
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
-
23298609,. PMID
-
Crespo J, Sun H, Welling TH, Tian Z, Zou W. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment. Curr Opin Immunol. 2013;25:214-21. doi:10.1016/j.coi.2012.12.003. PMID:23298609
-
(2013)
Curr Opin Immunol
, vol.25
, pp. 214-221
-
-
Crespo, J.1
Sun, H.2
Welling, T.H.3
Tian, Z.4
Zou, W.5
-
28
-
-
84951310757
-
NK cells and cancer: you can teach innate cells new tricks
-
26694935,. PMID
-
Morvan MG, Lanier LL. NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer. 2016;16:7-19. doi:10.1038/nrc.2015.5. PMID:26694935
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 7-19
-
-
Morvan, M.G.1
Lanier, L.L.2
-
29
-
-
84925743331
-
Balancing natural killer cell activation through paired receptors
-
25743219,. PMID
-
Martinet L, Smyth MJ. Balancing natural killer cell activation through paired receptors. Nat Rev Immunol. 2015;15:243-54. doi:10.1038/nri3799. PMID:25743219
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 243-254
-
-
Martinet, L.1
Smyth, M.J.2
-
30
-
-
1542615649
-
Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future
-
15039756,. PMID
-
Vivier E, Anfossi N. Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Nat Rev Immunol. 2004;4:190-8. doi:10.1038/nri1306. PMID:15039756
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 190-198
-
-
Vivier, E.1
Anfossi, N.2
-
31
-
-
84858784892
-
Targeting natural killer cells and natural killer T cells in cancer
-
22437937,. PMID
-
Vivier E, Ugolini S, Blaise D, Chabannon C, Brossay L. Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol. 2012;12:239-52. doi:10.1038/nri3174. PMID:22437937
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 239-252
-
-
Vivier, E.1
Ugolini, S.2
Blaise, D.3
Chabannon, C.4
Brossay, L.5
-
32
-
-
84944277572
-
Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells
-
26140242,. PMID
-
Wu AA, Drake V, Huang HS, Chiu S, Zheng L. Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells. Oncoimmunology. 2015;4:e1016700. doi:10.1080/2162402X.2015.1016700. PMID:26140242
-
(2015)
Oncoimmunology
, vol.4
, pp. 1016700
-
-
Wu, A.A.1
Drake, V.2
Huang, H.S.3
Chiu, S.4
Zheng, L.5
-
33
-
-
84982144414
-
Regulatory circuits of T cell function in cancer
-
27526640,. PMID
-
Speiser DE, Ho PC, Verdeil G. Regulatory circuits of T cell function in cancer. Nat Rev Immunol. 2016;16:599-611. doi:10.1038/nri.2016.80. PMID:27526640
-
(2016)
Nat Rev Immunol
, vol.16
, pp. 599-611
-
-
Speiser, D.E.1
Ho, P.C.2
Verdeil, G.3
-
34
-
-
84945451852
-
Immunological hallmarks of stromal cells in the tumour microenvironment
-
26471778,. PMID
-
Turley SJ, Cremasco V, Astarita JL. Immunological hallmarks of stromal cells in the tumour microenvironment. Nat Rev Immunol. 2015;15:669-82. doi:10.1038/nri3902. PMID:26471778
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 669-682
-
-
Turley, S.J.1
Cremasco, V.2
Astarita, J.L.3
-
35
-
-
85021662906
-
IFNgamma-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment
-
28666115, et al.,. PMID
-
Nirschl CJ, Suarez-Farinas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, et al. IFNgamma-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017;170:127-41.e15. doi:10.1016/j.cell.2017.06.016. PMID:28666115
-
(2017)
Cell
, vol.170
, pp. 127-141
-
-
Nirschl, C.J.1
Suarez-Farinas, M.2
Izar, B.3
Prakadan, S.4
Dannenfelser, R.5
Tirosh, I.6
Liu, Y.7
Zhu, Q.8
Devi, K.S.P.9
Carroll, S.L.10
-
36
-
-
85018766073
-
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses
-
28475900, et al.,. PMID
-
Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, Remark R, Sweeney R, Becker CD, Levine JH, et al. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. Cell. 2017;169:750-65.e17. doi:10.1016/j.cell.2017.04.014. PMID:28475900
-
(2017)
Cell
, vol.169
, pp. 750-765
-
-
Lavin, Y.1
Kobayashi, S.2
Leader, A.3
Amir, E.D.4
Elefant, N.5
Bigenwald, C.6
Remark, R.7
Sweeney, R.8
Becker, C.D.9
Levine, J.H.10
-
37
-
-
85018787063
-
An Immune Atlas of Clear Cell Renal Cell Carcinoma
-
28475899, et al.,. PMID
-
Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, et al. An Immune Atlas of Clear Cell Renal Cell Carcinoma. Cell. 2017;169:736-49.e18. doi:10.1016/j.cell.2017.04.016. PMID:28475899
-
(2017)
Cell
, vol.169
, pp. 736-749
-
-
Chevrier, S.1
Levine, J.H.2
Zanotelli, V.R.T.3
Silina, K.4
Schulz, D.5
Bacac, M.6
Ries, C.H.7
Ailles, L.8
Jewett, M.A.S.9
Moch, H.10
-
38
-
-
85010791215
-
Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
-
27974686,. PMID
-
Kroemer G, Galluzzi L. Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors. Oncotarget. 2017;8:5686-91. PMID:27974686
-
(2017)
Oncotarget
, vol.8
, pp. 5686-5691
-
-
Kroemer, G.1
Galluzzi, L.2
-
39
-
-
85017446141
-
Immunotherapy: Hiding in plain sight: immune escape in the era of targeted T-cell-based immunotherapies
-
28397826,. PMID
-
Daniyan AF, Brentjens RJ. Immunotherapy: Hiding in plain sight: immune escape in the era of targeted T-cell-based immunotherapies. Nat Rev Clin Oncol. 2017;14:333-4. doi:10.1038/nrclinonc.2017.49. PMID:28397826
-
(2017)
Nat Rev Clin Oncol
, vol.14
, pp. 333-334
-
-
Daniyan, A.F.1
Brentjens, R.J.2
-
40
-
-
84921418427
-
Classification of current anticancer immunotherapies
-
25537519, et al.,. PMID
-
Galluzzi L, Vacchelli E, Bravo-San Pedro JM, Buque A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado JP, Agostinis P, et al. Classification of current anticancer immunotherapies. Oncotarget. 2014;5:12472-508. doi:10.18632/oncotarget.2998. PMID:25537519
-
(2014)
Oncotarget
, vol.5
, pp. 12472-12508
-
-
Galluzzi, L.1
Vacchelli, E.2
Bravo-San Pedro, J.M.3
Buque, A.4
Senovilla, L.5
Baracco, E.E.6
Bloy, N.7
Castoldi, F.8
Abastado, J.P.9
Agostinis, P.10
-
41
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
22437870,. PMID
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252-64. doi:10.1038/nrc3239. PMID:22437870
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
42
-
-
85029354547
-
Monitoring immune-checkpoint blockade: response evaluation and biomarker development
-
28653677,;in press. PMID
-
Nishino M, Ramaiya NH, Hatabu H, Hodi FS. Monitoring immune-checkpoint blockade: response evaluation and biomarker development. Nat Rev Clin Oncol. 2017;in press. doi:10.1038/nrclinonc.2017.88. PMID:28653677
-
(2017)
Nat Rev Clin Oncol
-
-
Nishino, M.1
Ramaiya, N.H.2
Hatabu, H.3
Hodi, F.S.4
-
43
-
-
84963621254
-
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
-
27079802,. PMID
-
Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016;16:275-87. doi:10.1038/nrc.2016.36. PMID:27079802
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 275-287
-
-
Topalian, S.L.1
Taube, J.M.2
Anders, R.A.3
Pardoll, D.M.4
-
44
-
-
84927130807
-
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
-
25860605,. PMID
-
Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161:205-14. doi:10.1016/j.cell.2015.03.030. PMID:25860605
-
(2015)
Cell
, vol.161
, pp. 205-214
-
-
Sharma, P.1
Allison, J.P.2
-
45
-
-
84928774156
-
The future of immune checkpoint therapy
-
25838373,. PMID
-
Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348:56-61. doi:10.1126/science.aaa8172. PMID:25838373
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
46
-
-
80054875641
-
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps
-
22020206,. PMID
-
Sharma P, Wagner K, Wolchok JD, Allison JP. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat Rev Cancer. 2011;11:805-12. doi:10.1038/nrc3153. PMID:22020206
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 805-812
-
-
Sharma, P.1
Wagner, K.2
Wolchok, J.D.3
Allison, J.P.4
-
47
-
-
84966738229
-
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
-
27192563,. PMID
-
Schildberg FA, Klein SR, Freeman GJ, Sharpe AH. Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family. Immunity. 2016;44:955-72. doi:10.1016/j.immuni.2016.05.002. PMID:27192563
-
(2016)
Immunity
, vol.44
, pp. 955-972
-
-
Schildberg, F.A.1
Klein, S.R.2
Freeman, G.J.3
Sharpe, A.H.4
-
48
-
-
85026265866
-
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
-
28596308, et al.,. PMID
-
Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 2017;357:409-13. doi:10.1126/science.aan6733. PMID:28596308
-
(2017)
Science
, vol.357
, pp. 409-413
-
-
Le, D.T.1
Durham, J.N.2
Smith, K.N.3
Wang, H.4
Bartlett, B.R.5
Aulakh, L.K.6
Lu, S.7
Kemberling, H.8
Wilt, C.9
Luber, B.S.10
-
49
-
-
84986253403
-
Trial Watch: Immunotherapy plus radiation therapy for oncological indications
-
27757313, et al.,. PMID
-
Vacchelli E, Bloy N, Aranda F, Buque A, Cremer I, Demaria S, Eggermont A, Formenti SC, Fridman WH, Fucikova J, et al. Trial Watch: Immunotherapy plus radiation therapy for oncological indications. Oncoimmunology. 2016;5:e1214790. doi:10.1080/2162402X.2016.1214790. PMID:27757313
-
(2016)
Oncoimmunology
, vol.5
, pp. 1214790
-
-
Vacchelli, E.1
Bloy, N.2
Aranda, F.3
Buque, A.4
Cremer, I.5
Demaria, S.6
Eggermont, A.7
Formenti, S.C.8
Fridman, W.H.9
Fucikova, J.10
-
50
-
-
84879625854
-
New checkpoint inhibitors ride the immunotherapy tsunami
-
23812256,. PMID
-
Mullard A. New checkpoint inhibitors ride the immunotherapy tsunami. Nat Rev Drug Discov. 2013;12:489-92. doi:10.1038/nrd4066. PMID:23812256
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 489-492
-
-
Mullard, A.1
-
51
-
-
85009740675
-
Robust detection of immune transcripts in FFPE samples using targeted RNA sequencing
-
27911273, et al.,. PMID
-
Paluch BE, Glenn ST, Conroy JM, Papanicolau-Sengos A, Bshara W, Omilian AR, Brese E, Nesline M, Burgher B, Andreas J, et al. Robust detection of immune transcripts in FFPE samples using targeted RNA sequencing. Oncotarget. 2017;8:3197-205. PMID:27911273
-
(2017)
Oncotarget
, vol.8
, pp. 3197-3205
-
-
Paluch, B.E.1
Glenn, S.T.2
Conroy, J.M.3
Papanicolau-Sengos, A.4
Bshara, W.5
Omilian, A.R.6
Brese, E.7
Nesline, M.8
Burgher, B.9
Andreas, J.10
-
52
-
-
85008395037
-
Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity
-
28057932,. PMID
-
Lesterhuis WJ, Bosco A, Millward MJ, Small M, Nowak AK, Lake RA. Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity. Nat Rev Drug Discov. 2017;16:264-72. doi:10.1038/nrd.2016.233. PMID:28057932
-
(2017)
Nat Rev Drug Discov
, vol.16
, pp. 264-272
-
-
Lesterhuis, W.J.1
Bosco, A.2
Millward, M.J.3
Small, M.4
Nowak, A.K.5
Lake, R.A.6
-
53
-
-
84956619454
-
Acquired resistance to immunotherapy and future challenges
-
26822578,. PMID
-
Restifo NP, Smyth MJ, Snyder A. Acquired resistance to immunotherapy and future challenges. Nat Rev Cancer. 2016;16:121-6. doi:10.1038/nrc.2016.2. PMID:26822578
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 121-126
-
-
Restifo, N.P.1
Smyth, M.J.2
Snyder, A.3
-
54
-
-
85014681380
-
Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
-
28251903, et al.,. PMID
-
Roh W, Chen PL, Reuben A, Spencer CN, Prieto PA, Miller JP, Gopalakrishnan V, Wang F, Cooper ZA, Reddy SM, et al. Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Sci Transl Med. 2017;9:eaah3560. doi:10.1126/scitranslmed.aah3560. PMID:28251903
-
(2017)
Sci Transl Med
, vol.9
, pp. aah3560
-
-
Roh, W.1
Chen, P.L.2
Reuben, A.3
Spencer, C.N.4
Prieto, P.A.5
Miller, J.P.6
Gopalakrishnan, V.7
Wang, F.8
Cooper, Z.A.9
Reddy, S.M.10
-
55
-
-
85014004127
-
Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy
-
27821490, et al.,. PMID
-
Wang X, Schoenhals JE, Li A, Valdecanas DR, Ye H, Zang F, Tang C, Tang M, Liu CG, Liu X, et al. Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy. Cancer Res. 2017;77:839-50. doi:10.1158/0008-5472.CAN-15-3142. PMID:27821490
-
(2017)
Cancer Res
, vol.77
, pp. 839-850
-
-
Wang, X.1
Schoenhals, J.E.2
Li, A.3
Valdecanas, D.R.4
Ye, H.5
Zang, F.6
Tang, C.7
Tang, M.8
Liu, C.G.9
Liu, X.10
-
56
-
-
84990849572
-
Loss of IFN-gamma Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
-
27667683, et al.,. PMID
-
Gao J, Shi LZ, Zhao H, Chen J, Xiong L, He Q, Chen T, Roszik J, Bernatchez C, Woodman SE, et al. Loss of IFN-gamma Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016;167:397-404.e9. doi:10.1016/j.cell.2016.08.069. PMID:27667683
-
(2016)
Cell
, vol.167
, pp. 397-404
-
-
Gao, J.1
Shi, L.Z.2
Zhao, H.3
Chen, J.4
Xiong, L.5
He, Q.6
Chen, T.7
Roszik, J.8
Bernatchez, C.9
Woodman, S.E.10
-
57
-
-
85012158583
-
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
-
28187290,. PMID
-
Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A. Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy. Cell. 2017;168:707-23. doi:10.1016/j.cell.2017.01.017. PMID:28187290
-
(2017)
Cell
, vol.168
, pp. 707-723
-
-
Sharma, P.1
Hu-Lieskovan, S.2
Wargo, J.A.3
Ribas, A.4
-
58
-
-
84961221351
-
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
-
26997480, et al.,. PMID
-
Hugo W, Zaretsky JM, Sun L, Song C, Moreno BH, Hu-Lieskovan S, Berent-Maoz B, Pang J, Chmielowski B, Cherry G, et al. Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma. Cell. 2016;165:35-44. doi:10.1016/j.cell.2016.02.065. PMID:26997480
-
(2016)
Cell
, vol.165
, pp. 35-44
-
-
Hugo, W.1
Zaretsky, J.M.2
Sun, L.3
Song, C.4
Moreno, B.H.5
Hu-Lieskovan, S.6
Berent-Maoz, B.7
Pang, J.8
Chmielowski, B.9
Cherry, G.10
-
59
-
-
84995948061
-
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kgamma in myeloid cells
-
27828943, et al.,. PMID
-
De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Cymerman DH, Budhu S, Ghosh A, Pink M, Tchaicha J, et al. Overcoming resistance to checkpoint blockade therapy by targeting PI3Kgamma in myeloid cells. Nature. 2016;539:443-7. doi:10.1038/nature20554. PMID:27828943
-
(2016)
Nature
, vol.539
, pp. 443-447
-
-
De Henau, O.1
Rausch, M.2
Winkler, D.3
Campesato, L.F.4
Liu, C.5
Cymerman, D.H.6
Budhu, S.7
Ghosh, A.8
Pink, M.9
Tchaicha, J.10
-
60
-
-
85013925425
-
Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma
-
28228279, et al.,. PMID
-
George S, Miao D, Demetri GD, Adeegbe D, Rodig SJ, Shukla S, Lipschitz M, Amin-Mansour A, Raut CP, Carter SL, et al. Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma. Immunity. 2017;46:197-204. doi:10.1016/j.immuni.2017.02.001. PMID:28228279
-
(2017)
Immunity
, vol.46
, pp. 197-204
-
-
George, S.1
Miao, D.2
Demetri, G.D.3
Adeegbe, D.4
Rodig, S.J.5
Shukla, S.6
Lipschitz, M.7
Amin-Mansour, A.8
Raut, C.P.9
Carter, S.L.10
-
61
-
-
84959440182
-
Trial Watch-Oncolytic viruses and cancer therapy
-
27057469, et al.,. PMID
-
Pol J, Buque A, Aranda F, Bloy N, Cremer I, Eggermont A, Erbs P, Fucikova J, Galon J, Limacher JM, et al. Trial Watch-Oncolytic viruses and cancer therapy. Oncoimmunology. 2016;5:e1117740. doi:10.1080/2162402X.2015.1117740. PMID:27057469
-
(2016)
Oncoimmunology
, vol.5
, pp. 1117740
-
-
Pol, J.1
Buque, A.2
Aranda, F.3
Bloy, N.4
Cremer, I.5
Eggermont, A.6
Erbs, P.7
Fucikova, J.8
Galon, J.9
Limacher, J.M.10
-
62
-
-
84969627158
-
Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy
-
27471617, et al.,. PMID
-
Buque A, Bloy N, Aranda F, Cremer I, Eggermont A, Fridman WH, Fucikova J, Galon J, Spisek R, Tartour E, et al. Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy. Oncoimmunology. 2016;5:e1149674. doi:10.1080/2162402X.2016.1149674. PMID:27471617
-
(2016)
Oncoimmunology
, vol.5
, pp. 1149674
-
-
Buque, A.1
Bloy, N.2
Aranda, F.3
Cremer, I.4
Eggermont, A.5
Fridman, W.H.6
Fucikova, J.7
Galon, J.8
Spisek, R.9
Tartour, E.10
-
63
-
-
84940890382
-
Big opportunities for small molecules in immuno-oncology
-
26228631,. PMID
-
Adams JL, Smothers J, Srinivasan R, Hoos A. Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov. 2015;14:603-22. doi:10.1038/nrd4596. PMID:26228631
-
(2015)
Nat Rev Drug Discov
, vol.14
, pp. 603-622
-
-
Adams, J.L.1
Smothers, J.2
Srinivasan, R.3
Hoos, A.4
-
64
-
-
84960366855
-
Development of immuno-oncology drugs–from CTLA4 to PD1 to the next generations
-
26965203,. PMID
-
Hoos A. Development of immuno-oncology drugs–from CTLA4 to PD1 to the next generations. Nat Rev Drug Discov. 2016;15:235-47. doi:10.1038/nrd.2015.35. PMID:26965203
-
(2016)
Nat Rev Drug Discov
, vol.15
, pp. 235-247
-
-
Hoos, A.1
-
65
-
-
84984677958
-
Engineered T cells: the promise and challenges of cancer immunotherapy
-
27550819,. PMID
-
Fesnak AD, June CH, Levine BL. Engineered T cells: the promise and challenges of cancer immunotherapy. Nat Rev Cancer. 2016;16:566-81. doi:10.1038/nrc.2016.97. PMID:27550819
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 566-581
-
-
Fesnak, A.D.1
June, C.H.2
Levine, B.L.3
-
66
-
-
84940824279
-
Oncolytic viruses: a new class of immunotherapy drugs
-
26323545,. PMID
-
Kaufman HL, Kohlhapp FJ, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs. Nat Rev Drug Discov. 2015;14:642-62. doi:10.1038/nrd4663. PMID:26323545
-
(2015)
Nat Rev Drug Discov
, vol.14
, pp. 642-662
-
-
Kaufman, H.L.1
Kohlhapp, F.J.2
Zloza, A.3
-
67
-
-
84940378016
-
Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS
-
26320067,. PMID
-
Sanmamed MF, Pastor F, Rodriguez A, Perez-Gracia JL, Rodriguez-Ruiz ME, Jure-Kunkel M, Melero I. Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS. Semin Oncol. 2015;42:640-55. doi:10.1053/j.seminoncol.2015.05.014. PMID:26320067
-
(2015)
Semin Oncol
, vol.42
, pp. 640-655
-
-
Sanmamed, M.F.1
Pastor, F.2
Rodriguez, A.3
Perez-Gracia, J.L.4
Rodriguez-Ruiz, M.E.5
Jure-Kunkel, M.6
Melero, I.7
-
68
-
-
84874909144
-
Agonist antibodies to TNFR molecules that costimulate T and NK cells
-
23460535,. PMID
-
Melero I, Hirschhorn-Cymerman D, Morales-Kastresana A, Sanmamed MF, Wolchok JD. Agonist antibodies to TNFR molecules that costimulate T and NK cells. Clin Cancer Res. 2013;19:1044-53. doi:10.1158/1078-0432.CCR-12-2065. PMID:23460535
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1044-1053
-
-
Melero, I.1
Hirschhorn-Cymerman, D.2
Morales-Kastresana, A.3
Sanmamed, M.F.4
Wolchok, J.D.5
-
69
-
-
84953445855
-
Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
-
26137403, et al.,. PMID
-
Buque A, Bloy N, Aranda F, Castoldi F, Eggermont A, Cremer I, Fridman WH, Fucikova J, Galon J, Marabelle A, et al. Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications. Oncoimmunology. 2015;4:e1008814. doi:10.1080/2162402X.2015.1008814. PMID:26137403
-
(2015)
Oncoimmunology
, vol.4
, pp. 1008814
-
-
Buque, A.1
Bloy, N.2
Aranda, F.3
Castoldi, F.4
Eggermont, A.5
Cremer, I.6
Fridman, W.H.7
Fucikova, J.8
Galon, J.9
Marabelle, A.10
-
70
-
-
84994876820
-
Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format
-
27999756,. PMID
-
Fellermeier S, Beha N, Meyer JE, Ring S, Bader S, Kontermann RE, Muller D. Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format. Oncoimmunology. 2016;5:e1238540. doi:10.1080/2162402X.2016.1238540. PMID:27999756
-
(2016)
Oncoimmunology
, vol.5
, pp. 1238540
-
-
Fellermeier, S.1
Beha, N.2
Meyer, J.E.3
Ring, S.4
Bader, S.5
Kontermann, R.E.6
Muller, D.7
-
71
-
-
84942308926
-
Development of Next-Generation Immunomodulatory Antibodies for Cancer Therapy through Optimization of the IgG Framework
-
26373272,. PMID
-
Offringa R, Glennie MJ. Development of Next-Generation Immunomodulatory Antibodies for Cancer Therapy through Optimization of the IgG Framework. Cancer Cell. 2015;28:273-5. doi:10.1016/j.ccell.2015.08.008. PMID:26373272
-
(2015)
Cancer Cell
, vol.28
, pp. 273-275
-
-
Offringa, R.1
Glennie, M.J.2
-
72
-
-
84961223438
-
Therapeutic targeting of CD70 and CD27
-
26914723,. PMID
-
Wajant H. Therapeutic targeting of CD70 and CD27. Expert Opin Ther Targets. 2016;20:959-73. doi:10.1517/14728222.2016.1158812. PMID:26914723
-
(2016)
Expert Opin Ther Targets
, vol.20
, pp. 959-973
-
-
Wajant, H.1
-
73
-
-
85015668016
-
Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer
-
28319731,. PMID
-
Bullock TN. Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer. Curr Opin Immunol. 2017;45:82-8. doi:10.1016/j.coi.2017.02.001. PMID:28319731
-
(2017)
Curr Opin Immunol
, vol.45
, pp. 82-88
-
-
Bullock, T.N.1
-
74
-
-
84872806869
-
The CD70-CD27 axis, a new brake in the T helper 17 cell response
-
23352216,. PMID
-
Wang X, Dong C. The CD70-CD27 axis, a new brake in the T helper 17 cell response. Immunity. 2013;38:1-3. doi:10.1016/j.immuni.2013.01.005. PMID:23352216
-
(2013)
Immunity
, vol.38
, pp. 1-3
-
-
Wang, X.1
Dong, C.2
-
75
-
-
84937852364
-
The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy
-
25550693,. PMID
-
Leung J, Suh WK. The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy. Immune Netw. 2014;14:265-76. doi:10.4110/in.2014.14.6.265. PMID:25550693
-
(2014)
Immune Netw
, vol.14
, pp. 265-276
-
-
Leung, J.1
Suh, W.K.2
-
76
-
-
85015679329
-
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent
-
28280249, et al.,. PMID
-
Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science. 2017;355:1423-7. doi:10.1126/science.aaf0683. PMID:28280249
-
(2017)
Science
, vol.355
, pp. 1423-1427
-
-
Kamphorst, A.O.1
Wieland, A.2
Nasti, T.3
Yang, S.4
Zhang, R.5
Barber, D.L.6
Konieczny, B.T.7
Daugherty, C.Z.8
Koenig, L.9
Yu, K.10
-
77
-
-
85015665428
-
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
-
28280247, et al.,. PMID
-
Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355:1428-33. doi:10.1126/science.aaf1292. PMID:28280247
-
(2017)
Science
, vol.355
, pp. 1428-1433
-
-
Hui, E.1
Cheung, J.2
Zhu, J.3
Su, X.4
Taylor, M.J.5
Wallweber, H.A.6
Sasmal, D.K.7
Huang, J.8
Kim, J.M.9
Mellman, I.10
-
78
-
-
84874845333
-
Agonistic CD40 antibodies and cancer therapy
-
23460534,. PMID
-
Vonderheide RH, Glennie MJ. Agonistic CD40 antibodies and cancer therapy. Clin Cancer Res. 2013;19:1035-43. doi:10.1158/1078-0432.CCR-12-2064. PMID:23460534
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1035-1043
-
-
Vonderheide, R.H.1
Glennie, M.J.2
-
79
-
-
85010917048
-
Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists
-
27927088,. PMID
-
Beatty GL, Li Y, Long KB. Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists. Expert Rev Anticancer Ther. 2017;17:175-86. doi:10.1080/14737140.2017.1270208. PMID:27927088
-
(2017)
Expert Rev Anticancer Ther
, vol.17
, pp. 175-186
-
-
Beatty, G.L.1
Li, Y.2
Long, K.B.3
-
80
-
-
84975105592
-
CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer
-
27292635,. PMID
-
Byrne KT, Vonderheide RH. CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. Cell Rep. 2016;15:2719-32. doi:10.1016/j.celrep.2016.05.058. PMID:27292635
-
(2016)
Cell Rep
, vol.15
, pp. 2719-2732
-
-
Byrne, K.T.1
Vonderheide, R.H.2
-
81
-
-
79952808845
-
CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma
-
et al
-
Burington B, Yue P, Shi X, Advani R, Lau JT, Tan J, Stinson S, Stinson J, Januario T, de Vos S, et al. CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma. Sci Transl Med. 2011;3:74ra22. doi:10.1126/scitranslmed.3001620.
-
(2011)
Sci Transl Med
, vol.3
, pp. 74ra22
-
-
Burington, B.1
Yue, P.2
Shi, X.3
Advani, R.4
Lau, J.T.5
Tan, J.6
Stinson, S.7
Stinson, J.8
Januario, T.9
de Vos, S.10
-
82
-
-
9144261696
-
Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication
-
15557168,. PMID
-
van Mierlo GJ, Boonman ZF, Dumortier HM, den Boer AT, Fransen MF, Nouta J, van der Voort EI, Offringa R, Toes RE, Melief CJ. Activation of dendritic cells that cross-present tumor-derived antigen licenses CD8+ CTL to cause tumor eradication. J Immunol. 2004;173:6753-9. doi:10.4049/jimmunol.173.11.6753. PMID:15557168
-
(2004)
J Immunol
, vol.173
, pp. 6753-6759
-
-
van Mierlo, G.J.1
Boonman, Z.F.2
Dumortier, H.M.3
den Boer, A.T.4
Fransen, M.F.5
Nouta, J.6
van der Voort, E.I.7
Offringa, R.8
Toes, R.E.9
Melief, C.J.10
-
83
-
-
84948466049
-
Rationale for anti-OX40 cancer immunotherapy
-
26645943,. PMID
-
Aspeslagh S, Postel-Vinay S, Rusakiewicz S, Soria JC, Zitvogel L, Marabelle A. Rationale for anti-OX40 cancer immunotherapy. Eur J Cancer. 2016;52:50-66. doi:10.1016/j.ejca.2015.08.021. PMID:26645943
-
(2016)
Eur J Cancer
, vol.52
, pp. 50-66
-
-
Aspeslagh, S.1
Postel-Vinay, S.2
Rusakiewicz, S.3
Soria, J.C.4
Zitvogel, L.5
Marabelle, A.6
-
84
-
-
84923537886
-
OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal
-
25763356,. PMID
-
Linch SN, McNamara MJ, Redmond WL. OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal. Front Oncol. 2015;5:34. doi:10.3389/fonc.2015.00034. PMID:25763356
-
(2015)
Front Oncol
, vol.5
, pp. 34
-
-
Linch, S.N.1
McNamara, M.J.2
Redmond, W.L.3
-
85
-
-
2942592429
-
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
-
15173831,. PMID
-
Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol. 2004;4:420-31. doi:10.1038/nri1371. PMID:15173831
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 420-431
-
-
Sugamura, K.1
Ishii, N.2
Weinberg, A.D.3
-
86
-
-
84978543393
-
Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity
-
27622048,. PMID
-
Souza-Fonseca-Guimaraes F, Blake SJ, Makkouk A, Chester C, Kohrt HE, Smyth MJ. Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity. Oncoimmunology. 2016;5:e1192740. doi:10.1080/2162402X.2016.1192740. PMID:27622048
-
(2016)
Oncoimmunology
, vol.5
, pp. 1192740
-
-
Souza-Fonseca-Guimaraes, F.1
Blake, S.J.2
Makkouk, A.3
Chester, C.4
Kohrt, H.E.5
Smyth, M.J.6
-
87
-
-
84952932933
-
Rationale for anti-CD137 cancer immunotherapy
-
26751393,. PMID
-
Makkouk A, Chester C, Kohrt HE. Rationale for anti-CD137 cancer immunotherapy. Eur J Cancer. 2016;54:112-9. doi:10.1016/j.ejca.2015.09.026. PMID:26751393
-
(2016)
Eur J Cancer
, vol.54
, pp. 112-119
-
-
Makkouk, A.1
Chester, C.2
Kohrt, H.E.3
-
88
-
-
84962157662
-
4-1BB agonism: adding the accelerator to cancer immunotherapy
-
27034234,. PMID
-
Chester C, Ambulkar S, Kohrt HE. 4-1BB agonism: adding the accelerator to cancer immunotherapy. Cancer Immunol Immunother. 2016;65:1243-8. doi:10.1007/s00262-016-1829-2. PMID:27034234
-
(2016)
Cancer Immunol Immunother
, vol.65
, pp. 1243-1248
-
-
Chester, C.1
Ambulkar, S.2
Kohrt, H.E.3
-
89
-
-
84944535134
-
Functional expression of CD137 (4-1BB) on T helper follicular cells
-
26587331, et al.,. PMID
-
Alfaro C, Echeveste JI, Rodriguez-Ruiz ME, Solorzano JL, Perez-Gracia JL, Idoate MA, Lopez-Picazo JM, Sanchez-Paulete AR, Labiano S, Rouzaut A, et al. Functional expression of CD137 (4-1BB) on T helper follicular cells. Oncoimmunology. 2015;4:e1054597. doi:10.1080/2162402X.2015.1054597. PMID:26587331
-
(2015)
Oncoimmunology
, vol.4
, pp. 1054597
-
-
Alfaro, C.1
Echeveste, J.I.2
Rodriguez-Ruiz, M.E.3
Solorzano, J.L.4
Perez-Gracia, J.L.5
Idoate, M.A.6
Lopez-Picazo, J.M.7
Sanchez-Paulete, A.R.8
Labiano, S.9
Rouzaut, A.10
-
90
-
-
84984604984
-
Rationale for anti-GITR cancer immunotherapy
-
27591414,. PMID
-
Knee DA, Hewes B, Brogdon JL. Rationale for anti-GITR cancer immunotherapy. Eur J Cancer. 2016;67:1-10. doi:10.1016/j.ejca.2016.06.028. PMID:27591414
-
(2016)
Eur J Cancer
, vol.67
, pp. 1-10
-
-
Knee, D.A.1
Hewes, B.2
Brogdon, J.L.3
-
91
-
-
84954349721
-
GITR agonist enhances vaccination responses in lung cancer
-
26137407, et al.,. PMID
-
Zhu LX, Davoodi M, Srivastava MK, Kachroo P, Lee JM, St John M, Harris-White M, Huang M, Strieter RM, Dubinett S, et al. GITR agonist enhances vaccination responses in lung cancer. Oncoimmunology. 2015;4:e992237. doi:10.4161/2162402X.2014.992237. PMID:26137407
-
(2015)
Oncoimmunology
, vol.4
, pp. 992237
-
-
Zhu, L.X.1
Davoodi, M.2
Srivastava, M.K.3
Kachroo, P.4
Lee, J.M.5
St John, M.6
Harris-White, M.7
Huang, M.8
Strieter, R.M.9
Dubinett, S.10
-
92
-
-
79952770456
-
Anti-GITR antibodies–potential clinical applications for tumor immunotherapy
-
21154120,. PMID
-
Schaer DA, Cohen AD, Wolchok JD. Anti-GITR antibodies–potential clinical applications for tumor immunotherapy. Curr Opin Investig Drugs. 2010;11:1378-86. PMID:21154120
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 1378-1386
-
-
Schaer, D.A.1
Cohen, A.D.2
Wolchok, J.D.3
-
93
-
-
77952348017
-
Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)
-
20116985,. PMID
-
Simpson TR, Quezada SA, Allison JP. Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). Curr Opin Immunol. 2010;22:326-32. doi:10.1016/j.coi.2010.01.001. PMID:20116985
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 326-332
-
-
Simpson, T.R.1
Quezada, S.A.2
Allison, J.P.3
-
94
-
-
84962702960
-
ICOS Expression as Immunologic Marker in Immune Activating Monoclonal Antibodies
-
27033223,. PMID
-
Danielli R, Cutaia O, Fazio C, Bertocci E, Fonsatti E, Maio M, Calabro L. ICOS Expression as Immunologic Marker in Immune Activating Monoclonal Antibodies. Methods Mol Biol. 2016;1393:133-9. doi:10.1007/978-1-4939-3338-9_13. PMID:27033223
-
(2016)
Methods Mol Biol
, vol.1393
, pp. 133-139
-
-
Danielli, R.1
Cutaia, O.2
Fazio, C.3
Bertocci, E.4
Fonsatti, E.5
Maio, M.6
Calabro, L.7
-
95
-
-
84897940775
-
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy
-
24687957,. PMID
-
Fan X, Quezada SA, Sepulveda MA, Sharma P, Allison JP. Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy. J Exp Med. 2014;211:715-25. doi:10.1084/jem.20130590. PMID:24687957
-
(2014)
J Exp Med
, vol.211
, pp. 715-725
-
-
Fan, X.1
Quezada, S.A.2
Sepulveda, M.A.3
Sharma, P.4
Allison, J.P.5
-
96
-
-
84962795027
-
Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells
-
27141390,. PMID
-
van Dodewaard-de Jong JM, Santegoets SJ, van de Ven PM, Versluis J, Verheul HM, de Gruijl TD, Gerritsen WR, van den Eertwegh AJ. Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells. Oncoimmunology. 2016;5:e1105431. doi:10.1080/2162402X.2015.1105431. PMID:27141390
-
(2016)
Oncoimmunology
, vol.5
, pp. 1105431
-
-
van Dodewaard-de Jong, J.M.1
Santegoets, S.J.2
van de Ven, P.M.3
Versluis, J.4
Verheul, H.M.5
de Gruijl, T.D.6
Gerritsen, W.R.7
van den Eertwegh, A.J.8
-
97
-
-
84925121085
-
ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity
-
25769613,. PMID
-
Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O. ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity. 2015;42:538-51. doi:10.1016/j.immuni.2015.02.007. PMID:25769613
-
(2015)
Immunity
, vol.42
, pp. 538-551
-
-
Maazi, H.1
Patel, N.2
Sankaranarayanan, I.3
Suzuki, Y.4
Rigas, D.5
Soroosh, P.6
Freeman, G.J.7
Sharpe, A.H.8
Akbari, O.9
-
98
-
-
84945441052
-
CD70: An emerging target in cancer immunotherapy
-
26213107,. PMID
-
Jacobs J, Deschoolmeester V, Zwaenepoel K, Rolfo C, Silence K, Rottey S, Lardon F, Smits E, Pauwels P. CD70: An emerging target in cancer immunotherapy. Pharmacol Ther. 2015;155:1-10. doi:10.1016/j.pharmthera.2015.07.007. PMID:26213107
-
(2015)
Pharmacol Ther
, vol.155
, pp. 1-10
-
-
Jacobs, J.1
Deschoolmeester, V.2
Zwaenepoel, K.3
Rolfo, C.4
Silence, K.5
Rottey, S.6
Lardon, F.7
Smits, E.8
Pauwels, P.9
-
99
-
-
84944567385
-
Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma
-
26587319,. PMID
-
Ruf M, Moch H, Schraml P. Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma. Oncoimmunology. 2015;4:e1049805. doi:10.1080/2162402X.2015.1049805. PMID:26587319
-
(2015)
Oncoimmunology
, vol.4
, pp. 1049805
-
-
Ruf, M.1
Moch, H.2
Schraml, P.3
-
100
-
-
84883403813
-
CD70 is downregulated by interaction with CD27
-
23913967,. PMID
-
Kuka M, Munitic I, Giardino Torchia ML, Ashwell JD. CD70 is downregulated by interaction with CD27. J Immunol. 2013;191:2282-9. doi:10.4049/jimmunol.1300868. PMID:23913967
-
(2013)
J Immunol
, vol.191
, pp. 2282-2289
-
-
Kuka, M.1
Munitic, I.2
Giardino Torchia, M.L.3
Ashwell, J.D.4
-
101
-
-
84872827286
-
The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity
-
23159439,. PMID
-
Coquet JM, Middendorp S, van der Horst G, Kind J, Veraar EA, Xiao Y, Jacobs H, Borst J. The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. Immunity. 2013;38:53-65. doi:10.1016/j.immuni.2012.09.009. PMID:23159439
-
(2013)
Immunity
, vol.38
, pp. 53-65
-
-
Coquet, J.M.1
Middendorp, S.2
van der Horst, G.3
Kind, J.4
Veraar, E.A.5
Xiao, Y.6
Jacobs, H.7
Borst, J.8
-
102
-
-
84872724158
-
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus
-
23269247,. PMID
-
Munitic I, Kuka M, Allam A, Scoville JP, Ashwell JD. CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. J Immunol. 2013;190:1169-79. doi:10.4049/jimmunol.1202353. PMID:23269247
-
(2013)
J Immunol
, vol.190
, pp. 1169-1179
-
-
Munitic, I.1
Kuka, M.2
Allam, A.3
Scoville, J.P.4
Ashwell, J.D.5
-
103
-
-
84942300594
-
Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma
-
25949922,. PMID
-
Sato Y, Shimizu K, Shinga J, Hidaka M, Kawano F, Kakimi K, Yamasaki S, Asakura M, Fujii SI. Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma. Oncoimmunology. 2015;4:e995541. doi:10.1080/2162402X.2014.995541. PMID:25949922
-
(2015)
Oncoimmunology
, vol.4
, pp. 995541
-
-
Sato, Y.1
Shimizu, K.2
Shinga, J.3
Hidaka, M.4
Kawano, F.5
Kakimi, K.6
Yamasaki, S.7
Asakura, M.8
Fujii, S.I.9
-
104
-
-
9244231842
-
CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
-
15467723, et al.,. PMID
-
Orabona C, Grohmann U, Belladonna ML, Fallarino F, Vacca C, Bianchi R, Bozza S, Volpi C, Salomon BL, Fioretti MC, et al. CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86. Nat Immunol. 2004;5:1134-42. doi:10.1038/ni1124. PMID:15467723
-
(2004)
Nat Immunol
, vol.5
, pp. 1134-1142
-
-
Orabona, C.1
Grohmann, U.2
Belladonna, M.L.3
Fallarino, F.4
Vacca, C.5
Bianchi, R.6
Bozza, S.7
Volpi, C.8
Salomon, B.L.9
Fioretti, M.C.10
-
105
-
-
84864808097
-
Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells
-
22798683,. PMID
-
Bak SP, Barnkob MS, Bai A, Higham EM, Wittrup KD, Chen J. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol. 2012;189:1708-16. doi:10.4049/jimmunol.1201271. PMID:22798683
-
(2012)
J Immunol
, vol.189
, pp. 1708-1716
-
-
Bak, S.P.1
Barnkob, M.S.2
Bai, A.3
Higham, E.M.4
Wittrup, K.D.5
Chen, J.6
-
106
-
-
84995615046
-
T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells
-
27622331, et al.,. PMID
-
Marigo I, Zilio S, Desantis G, Mlecnik B, Agnellini AH, Ugel S, Sasso MS, Qualls JE, Kratochvill F, Zanovello P, et al. T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. Cancer Cell. 2016;30:377-90. doi:10.1016/j.ccell.2016.08.004. PMID:27622331
-
(2016)
Cancer Cell
, vol.30
, pp. 377-390
-
-
Marigo, I.1
Zilio, S.2
Desantis, G.3
Mlecnik, B.4
Agnellini, A.H.5
Ugel, S.6
Sasso, M.S.7
Qualls, J.E.8
Kratochvill, F.9
Zanovello, P.10
-
107
-
-
85007415459
-
CD40L confers helper functions to human intra-melanoma class-I-restricted CD4+CD8+ double positive T cells
-
28123891, et al.,. PMID
-
Parrot T, Oger R, Benlalam H, Raingeard de la Bletiere D, Jouand N, Coutolleau A, Preisser L, Khammari A, Dreno B, Guardiola P, et al. CD40L confers helper functions to human intra-melanoma class-I-restricted CD4+CD8+ double positive T cells. Oncoimmunology. 2016;5:e1250991. doi:10.1080/2162402X.2016.1250991. PMID:28123891
-
(2016)
Oncoimmunology
, vol.5
, pp. 1250991
-
-
Parrot, T.1
Oger, R.2
Benlalam, H.3
Raingeard de la Bletiere, D.4
Jouand, N.5
Coutolleau, A.6
Preisser, L.7
Khammari, A.8
Dreno, B.9
Guardiola, P.10
-
108
-
-
84979902229
-
Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy
-
27323820,. PMID
-
Shin CA, Cho HW, Shin AR, Sohn HJ, Cho HI, Kim TG. Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy. Oncotarget. 2016;7:46173-86. doi:10.18632/oncotarget.10068. PMID:27323820
-
(2016)
Oncotarget
, vol.7
, pp. 46173-46186
-
-
Shin, C.A.1
Cho, H.W.2
Shin, A.R.3
Sohn, H.J.4
Cho, H.I.5
Kim, T.G.6
-
109
-
-
84897032564
-
CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes
-
24481488,. PMID
-
Liljenfeldt L, Dieterich LC, Dimberg A, Mangsbo SM, Loskog AS. CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes. Cancer Gene Ther. 2014;21:95-102. doi:10.1038/cgt.2014.2. PMID:24481488
-
(2014)
Cancer Gene Ther
, vol.21
, pp. 95-102
-
-
Liljenfeldt, L.1
Dieterich, L.C.2
Dimberg, A.3
Mangsbo, S.M.4
Loskog, A.S.5
-
110
-
-
77953724187
-
OX40 (CD134) and OX40L
-
19760068,. PMID
-
Gough MJ, Weinberg AD. OX40 (CD134) and OX40L. Adv Exp Med Biol. 2009;647:94-107. doi:10.1007/978-0-387-89520-8_6. PMID:19760068
-
(2009)
Adv Exp Med Biol
, vol.647
, pp. 94-107
-
-
Gough, M.J.1
Weinberg, A.D.2
-
111
-
-
84969142767
-
Soluble OX40L favors tumor rejection in CT26 colon carcinoma model
-
27203665,. PMID
-
Serebrovskaya EO, Yuzhakova DV, Ryumina AP, Druzhkova IN, Sharonov GV, Kotlobay AA, Zagaynova EV, Lukyanov SA, Shirmanova MV. Soluble OX40L favors tumor rejection in CT26 colon carcinoma model. Cytokine. 2016;84:10-6. doi:10.1016/j.cyto.2016.05.005. PMID:27203665
-
(2016)
Cytokine
, vol.84
, pp. 10-16
-
-
Serebrovskaya, E.O.1
Yuzhakova, D.V.2
Ryumina, A.P.3
Druzhkova, I.N.4
Sharonov, G.V.5
Kotlobay, A.A.6
Zagaynova, E.V.7
Lukyanov, S.A.8
Shirmanova, M.V.9
-
112
-
-
79952508760
-
Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway
-
21397857,. PMID
-
Godefroy E, Manches O, Dreno B, Hochman T, Roldoi:nitzky L, Labarriere N, Guilloux Y, Goldberg J, Jotereau F, Bhardwaj N. Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway. Cancer Cell. 2011;19:333-46. doi:10.1016/j.ccr.2011.01.037. PMID:21397857
-
(2011)
Cancer Cell
, vol.19
, pp. 333-346
-
-
Godefroy, E.1
Manches, O.2
Dreno, B.3
Hochman, T.4
Roldoinitzky, L.5
Labarriere, N.6
Guilloux, Y.7
Goldberg, J.8
Jotereau, F.9
Bhardwaj, N.10
-
113
-
-
27744446078
-
Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL
-
16272289,. PMID
-
Serghides L, Bukczynski J, Wen T, Wang C, Routy JP, Boulassel MR, Sekaly RP, Ostrowski M, Bernard NF, Watts TH. Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL. J Immunol. 2005;175:6368-77. doi:10.4049/jimmunol.175.10.6368. PMID:16272289
-
(2005)
J Immunol
, vol.175
, pp. 6368-6377
-
-
Serghides, L.1
Bukczynski, J.2
Wen, T.3
Wang, C.4
Routy, J.P.5
Boulassel, M.R.6
Sekaly, R.P.7
Ostrowski, M.8
Bernard, N.F.9
Watts, T.H.10
-
114
-
-
85022188647
-
SA-4-1BBL/MPL as a novel immune adjuvant platform to combat cancer
-
26942082,. PMID
-
Srivastava AK, Yolcu ES, Dinc G, Sharma RK, Shirwan H. SA-4-1BBL/MPL as a novel immune adjuvant platform to combat cancer. Oncoimmunology. 2016;5:e1064580. doi:10.1080/2162402X.2015.1064580. PMID:26942082
-
(2016)
Oncoimmunology
, vol.5
, pp. 1064580
-
-
Srivastava, A.K.1
Yolcu, E.S.2
Dinc, G.3
Sharma, R.K.4
Shirwan, H.5
-
115
-
-
84973110970
-
CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth
-
27471634,. PMID
-
Rajendran S, Ho WT, Schwarz H. CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth. Oncoimmunology. 2016;5:e1160188. doi:10.1080/2162402X.2016.1160188. PMID:27471634
-
(2016)
Oncoimmunology
, vol.5
, pp. 1160188
-
-
Rajendran, S.1
Ho, W.T.2
Schwarz, H.3
-
116
-
-
0033560179
-
4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine
-
10202049,. PMID
-
Guinn BA, DeBenedette MA, Watts TH, Berinstein NL. 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. J Immunol. 1999;162:5003-10. PMID:10202049
-
(1999)
J Immunol
, vol.162
, pp. 5003-5010
-
-
Guinn, B.A.1
DeBenedette, M.A.2
Watts, T.H.3
Berinstein, N.L.4
-
117
-
-
34249077931
-
Cell surface 4-1BBL mediates sequential signaling pathways ‘downstream’ of TLR and is required for sustained TNF production in macrophages
-
17496895,. PMID
-
Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J. Cell surface 4-1BBL mediates sequential signaling pathways ‘downstream’ of TLR and is required for sustained TNF production in macrophages. Nat Immunol. 2007;8:601-9. doi:10.1038/ni1471. PMID:17496895
-
(2007)
Nat Immunol
, vol.8
, pp. 601-609
-
-
Kang, Y.J.1
Kim, S.O.2
Shimada, S.3
Otsuka, M.4
Seit-Nebi, A.5
Kwon, B.S.6
Watts, T.H.7
Han, J.8
-
118
-
-
84858236143
-
Pharmacological modulation of GITRL/GITR system: therapeutic perspectives
-
22029729,. PMID
-
Nocentini G, Ronchetti S, Petrillo MG, Riccardi C. Pharmacological modulation of GITRL/GITR system: therapeutic perspectives. Br J Pharmacol. 2012;165:2089-99. doi:10.1111/j.1476-5381.2011.01753.x. PMID:22029729
-
(2012)
Br J Pharmacol
, vol.165
, pp. 2089-2099
-
-
Nocentini, G.1
Ronchetti, S.2
Petrillo, M.G.3
Riccardi, C.4
-
119
-
-
84944578399
-
GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo
-
26587321, et al.,. PMID
-
Pedroza-Gonzalez A, Zhou G, Singh SP, Boor PP, Pan Q, Grunhagen D, de Jonge J, Tran TK, Verhoef C, JN IJ, et al. GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo. Oncoimmunology. 2015;4:e1051297. doi:10.1080/2162402X.2015.1051297. PMID:26587321
-
(2015)
Oncoimmunology
, vol.4
, pp. 1051297
-
-
Pedroza-Gonzalez, A.1
Zhou, G.2
Singh, S.P.3
Boor, P.P.4
Pan, Q.5
Grunhagen, D.6
de Jonge, J.7
Tran, T.K.8
Verhoef, C.9
Jn, I.10
-
120
-
-
84975879195
-
The clinical impact of ICOS signal in colorectal cancer patients
-
27467961,. PMID
-
Zhang Y, Luo Y, Qin SL, Mu YF, Qi Y, Yu MH, Zhong M. The clinical impact of ICOS signal in colorectal cancer patients. Oncoimmunology. 2016;5:e1141857. doi:10.1080/2162402X.2016.1141857. PMID:27467961
-
(2016)
Oncoimmunology
, vol.5
, pp. 1141857
-
-
Zhang, Y.1
Luo, Y.2
Qin, S.L.3
Mu, Y.F.4
Qi, Y.5
Yu, M.H.6
Zhong, M.7
-
121
-
-
80051694786
-
The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy
-
21708958,. PMID
-
Fu T, He Q, Sharma P. The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy. Cancer Res. 2011;71:5445-54. doi:10.1158/0008-5472.CAN-11-1138. PMID:21708958
-
(2011)
Cancer Res
, vol.71
, pp. 5445-5454
-
-
Fu, T.1
He, Q.2
Sharma, P.3
-
122
-
-
84923778281
-
T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
-
25317561,. PMID
-
Liu D, Xu H, Shih C, Wan Z, Ma X, Ma W, Luo D, Qi H. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature 2015;517:214-8. doi:10.1038/nature13803. PMID:25317561
-
(2015)
Nature
, vol.517
, pp. 214-218
-
-
Liu, D.1
Xu, H.2
Shih, C.3
Wan, Z.4
Ma, X.5
Ma, W.6
Luo, D.7
Qi, H.8
-
123
-
-
45949091620
-
ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival
-
18390727,. PMID
-
Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol 2008;180:5448-56. doi:10.4049/jimmunol.180.8.5448. PMID:18390727
-
(2008)
J Immunol
, vol.180
, pp. 5448-5456
-
-
Akbari, O.1
Stock, P.2
Meyer, E.H.3
Freeman, G.J.4
Sharpe, A.H.5
Umetsu, D.T.6
DeKruyff, R.H.7
-
124
-
-
84885466006
-
Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice
-
24026078, et al.,. PMID
-
He LZ, Prostak N, Thomas LJ, Vitale L, Weidlick J, Crocker A, Pilsmaker CD, Round SM, Tutt A, Glennie MJ, et al. Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice. J Immunol 2013;191:4174-83. doi:10.4049/jimmunol.1300409. PMID:24026078
-
(2013)
J Immunol
, vol.191
, pp. 4174-4183
-
-
He, L.Z.1
Prostak, N.2
Thomas, L.J.3
Vitale, L.4
Weidlick, J.5
Crocker, A.6
Pilsmaker, C.D.7
Round, S.M.8
Tutt, A.9
Glennie, M.J.10
-
125
-
-
84953284516
-
CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity
-
26608920,. PMID
-
Akhmetzyanova I, Zelinskyy G, Littwitz-Salomon E, Malyshkina A, Dietze KK, Streeck H, Brandau S, Dittmer U. CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity. J Immunol 2016;196:484-92. doi:10.4049/jimmunol.1403039. PMID:26608920
-
(2016)
J Immunol
, vol.196
, pp. 484-492
-
-
Akhmetzyanova, I.1
Zelinskyy, G.2
Littwitz-Salomon, E.3
Malyshkina, A.4
Dietze, K.K.5
Streeck, H.6
Brandau, S.7
Dittmer, U.8
-
126
-
-
42249097689
-
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
-
18362171,. PMID
-
Piconese S, Valzasina B, Colombo MP. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med 2008;205:825-39. doi:10.1084/jem.20071341. PMID:18362171
-
(2008)
J Exp Med
, vol.205
, pp. 825-839
-
-
Piconese, S.1
Valzasina, B.2
Colombo, M.P.3
-
127
-
-
0036170938
-
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
-
11812990,. PMID
-
Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002;3:135-42. doi:10.1038/ni759. PMID:11812990
-
(2002)
Nat Immunol
, vol.3
, pp. 135-142
-
-
Shimizu, J.1
Yamazaki, S.2
Takahashi, T.3
Ishida, Y.4
Sakaguchi, S.5
-
128
-
-
84897933432
-
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability
-
24416730, et al.,. PMID
-
Schaer DA, Budhu S, Liu C, Bryson C, Malandro N, Cohen A, Zhong H, Yang X, Houghton AN, Merghoub T, et al. GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability. Cancer Immunol Res 2013;1:320-31. doi:10.1158/2326-6066.CIR-13-0086. PMID:24416730
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 320-331
-
-
Schaer, D.A.1
Budhu, S.2
Liu, C.3
Bryson, C.4
Malandro, N.5
Cohen, A.6
Zhong, H.7
Yang, X.8
Houghton, A.N.9
Merghoub, T.10
-
129
-
-
84941022982
-
Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells
-
26280119, et al.,. PMID
-
Kim IK, Kim BS, Koh CH, Seok JW, Park JS, Shin KS, Bae EA, Lee GE, Jeon H, Cho J, et al. Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells. Nat Med. 2015;21:1010-7. doi:10.1038/nm.3922. PMID:26280119
-
(2015)
Nat Med
, vol.21
, pp. 1010-1017
-
-
Kim, I.K.1
Kim, B.S.2
Koh, C.H.3
Seok, J.W.4
Park, J.S.5
Shin, K.S.6
Bae, E.A.7
Lee, G.E.8
Jeon, H.9
Cho, J.10
-
130
-
-
84964689401
-
GITR drives TH9-mediated antitumor immunity
-
27467921,. PMID
-
Kim IK, Chung Y, Kang CY. GITR drives TH9-mediated antitumor immunity. Oncoimmunology. 2016;5:e1122862. doi:10.1080/2162402X.2015.1122862. PMID:27467921
-
(2016)
Oncoimmunology
, vol.5
, pp. 1122862
-
-
Kim, I.K.1
Chung, Y.2
Kang, C.Y.3
-
131
-
-
0034651736
-
Engagement of the OX-40 receptor in vivo enhances antitumor immunity
-
10657670,. PMID
-
Weinberg AD, Rivera MM, Prell R, Morris A, Ramstad T, Vetto JT, Urba WJ, Alvord G, Bunce C, Shields J. Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J Immunol. 2000;164:2160-9. doi:10.4049/jimmunol.164.4.2160. PMID:10657670
-
(2000)
J Immunol
, vol.164
, pp. 2160-2169
-
-
Weinberg, A.D.1
Rivera, M.M.2
Prell, R.3
Morris, A.4
Ramstad, T.5
Vetto, J.T.6
Urba, W.J.7
Alvord, G.8
Bunce, C.9
Shields, J.10
-
132
-
-
84976382144
-
Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer
-
27622025, et al.,. PMID
-
Timperi E, Pacella I, Schinzari V, Focaccetti C, Sacco L, Farelli F, Caronna R, Del Bene G, Longo F, Ciardi A, et al. Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer. Oncoimmunology. 2016;5:e1175800. doi:10.1080/2162402X.2016.1175800. PMID:27622025
-
(2016)
Oncoimmunology
, vol.5
, pp. 1175800
-
-
Timperi, E.1
Pacella, I.2
Schinzari, V.3
Focaccetti, C.4
Sacco, L.5
Farelli, F.6
Caronna, R.7
Del Bene, G.8
Longo, F.9
Ciardi, A.10
-
133
-
-
48549099849
-
OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor
-
18593921,. PMID
-
Gough MJ, Ruby CE, Redmond WL, Dhungel B, Brown A, Weinberg AD. OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor. Cancer Res. 2008;68:5206-15. doi:10.1158/0008-5472.CAN-07-6484. PMID:18593921
-
(2008)
Cancer Res
, vol.68
, pp. 5206-5215
-
-
Gough, M.J.1
Ruby, C.E.2
Redmond, W.L.3
Dhungel, B.4
Brown, A.5
Weinberg, A.D.6
-
134
-
-
84941670561
-
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation
-
26365427, et al.,. PMID
-
Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, Minze L, Fu YX, Ghobrial RM, Liu W, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266. doi:10.1038/ncomms9266. PMID:26365427
-
(2015)
Nat Commun
, vol.6
, pp. 8266
-
-
Xiao, X.1
Shi, X.2
Fan, Y.3
Zhang, X.4
Wu, M.5
Lan, P.6
Minze, L.7
Fu, Y.X.8
Ghobrial, R.M.9
Liu, W.10
-
135
-
-
84958625170
-
Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted
-
26423152,. PMID
-
Kim YH, Shin SM, Choi BK, Oh HS, Kim CH, Lee SJ, Kim KH, Lee DG, Park SH, Kwon BS. Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted. J Immunol. 2015;195:4721-9. doi:10.4049/jimmunol.1403076. PMID:26423152
-
(2015)
J Immunol
, vol.195
, pp. 4721-4729
-
-
Kim, Y.H.1
Shin, S.M.2
Choi, B.K.3
Oh, H.S.4
Kim, C.H.5
Lee, S.J.6
Kim, K.H.7
Lee, D.G.8
Park, S.H.9
Kwon, B.S.10
-
136
-
-
85015861938
-
Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy
-
28122327,. PMID
-
Mahne AE, Mauze S, Joyce-Shaikh B, Xia J, Bowman EP, Beebe AM, Cua DJ, Jain R. Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy. Cancer Res. 2017;77:1108-18. doi:10.1158/0008-5472.CAN-16-0797. PMID:28122327
-
(2017)
Cancer Res
, vol.77
, pp. 1108-1118
-
-
Mahne, A.E.1
Mauze, S.2
Joyce-Shaikh, B.3
Xia, J.4
Bowman, E.P.5
Beebe, A.M.6
Cua, D.J.7
Jain, R.8
-
137
-
-
84904038862
-
OX40 engagement depletes intratumoral Tregs via activating FcgammaRs, leading to antitumor efficacy
-
24732076,. PMID
-
Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS, Brogdon JL. OX40 engagement depletes intratumoral Tregs via activating FcgammaRs, leading to antitumor efficacy. Immunol Cell Biol. 2014;92:475-80. doi:10.1038/icb.2014.26. PMID:24732076
-
(2014)
Immunol Cell Biol
, vol.92
, pp. 475-480
-
-
Bulliard, Y.1
Jolicoeur, R.2
Zhang, J.3
Dranoff, G.4
Wilson, N.S.5
Brogdon, J.L.6
-
138
-
-
84884229186
-
Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
-
23897982,. PMID
-
Bulliard Y, Jolicoeur R, Windman M, Rue SM, Ettenberg S, Knee DA, Wilson NS, Dranoff G, Brogdon JL. Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med. 2013;210:1685-93. doi:10.1084/jem.20130573. PMID:23897982
-
(2013)
J Exp Med
, vol.210
, pp. 1685-1693
-
-
Bulliard, Y.1
Jolicoeur, R.2
Windman, M.3
Rue, S.M.4
Ettenberg, S.5
Knee, D.A.6
Wilson, N.S.7
Dranoff, G.8
Brogdon, J.L.9
-
139
-
-
78651466506
-
An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells
-
21251615, et al.,. PMID
-
Wilson NS, Yang B, Yang A, Loeser S, Marsters S, Lawrence D, Li Y, Pitti R, Totpal K, Yee S, et al. An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell. 2011;19:101-13. doi:10.1016/j.ccr.2010.11.012. PMID:21251615
-
(2011)
Cancer Cell
, vol.19
, pp. 101-113
-
-
Wilson, N.S.1
Yang, B.2
Yang, A.3
Loeser, S.4
Marsters, S.5
Lawrence, D.6
Li, Y.7
Pitti, R.8
Totpal, K.9
Yee, S.10
-
140
-
-
77958059390
-
Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells
-
20842060,. PMID
-
Roberts DJ, Franklin NA, Kingeter LM, Yagita H, Tutt AL, Glennie MJ, Bullock TN. Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells. J Immunother. 2010;33:769-79. doi:10.1097/CJI.0b013e3181ee238f. PMID:20842060
-
(2010)
J Immunother
, vol.33
, pp. 769-779
-
-
Roberts, D.J.1
Franklin, N.A.2
Kingeter, L.M.3
Yagita, H.4
Tutt, A.L.5
Glennie, M.J.6
Bullock, T.N.7
-
141
-
-
84935919398
-
Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb
-
26034288, et al.,. PMID
-
Weigelin B, Bolanos E, Teijeira A, Martinez-Forero I, Labiano S, Azpilikueta A, Morales-Kastresana A, Quetglas JI, Wagena E, Sanchez-Paulete AR, et al. Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb. Proc Natl Acad Sci U S A. 2015;112:7551-6. doi:10.1073/pnas.1506357112. PMID:26034288
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 7551-7556
-
-
Weigelin, B.1
Bolanos, E.2
Teijeira, A.3
Martinez-Forero, I.4
Labiano, S.5
Azpilikueta, A.6
Morales-Kastresana, A.7
Quetglas, J.I.8
Wagena, E.9
Sanchez-Paulete, A.R.10
-
142
-
-
0036195860
-
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
-
11877473,. PMID
-
Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest. 2002;109:651-9. doi:10.1172/JCI0214184. PMID:11877473
-
(2002)
J Clin Invest
, vol.109
, pp. 651-659
-
-
Wilcox, R.A.1
Flies, D.B.2
Zhu, G.3
Johnson, A.J.4
Tamada, K.5
Chapoval, A.I.6
Strome, S.E.7
Pease, L.R.8
Chen, L.9
-
143
-
-
85021095764
-
GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory
-
28649380,. PMID
-
Durham NM, Holoweckyj N, MacGill RS, McGlinchey K, Leow CC, Robbins SH. GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory. J Immunother Cancer. 2017;5:47. doi:10.1186/s40425-017-0247-0. PMID:28649380
-
(2017)
J Immunother Cancer
, vol.5
, pp. 47
-
-
Durham, N.M.1
Holoweckyj, N.2
MacGill, R.S.3
McGlinchey, K.4
Leow, C.C.5
Robbins, S.H.6
-
144
-
-
84964402230
-
Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS
-
27467927,. PMID
-
Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, Gismondi A, Santoni A, Nistico P. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203. doi:10.1080/2162402X.2015.1114203. PMID:27467927
-
(2016)
Oncoimmunology
, vol.5
, pp. 1114203
-
-
Franzese, O.1
Palermo, B.2
Di Donna, C.3
Sperduti, I.4
Ferraresi, V.5
Stabile, H.6
Gismondi, A.7
Santoni, A.8
Nistico, P.9
-
145
-
-
84976439348
-
Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma
-
27622011,. PMID
-
Homet Moreno B, Mok S, Comin-Anduix B, Hu-Lieskovan S, Ribas A. Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma. Oncoimmunology. 2016;5:e1052212. doi:10.1080/2162402X.2015.1052212. PMID:27622011
-
(2016)
Oncoimmunology
, vol.5
, pp. 1052212
-
-
Homet Moreno, B.1
Mok, S.2
Comin-Anduix, B.3
Hu-Lieskovan, S.4
Ribas, A.5
-
146
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
21436454, et al.,. PMID
-
Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, Huhn RD, Song W, Li D, Sharp LL, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 2011;331:1612-6. doi:10.1126/science.1198443. PMID:21436454
-
(2011)
Science
, vol.331
, pp. 1612-1616
-
-
Beatty, G.L.1
Chiorean, E.G.2
Fishman, M.P.3
Saboury, B.4
Teitelbaum, U.R.5
Sun, W.6
Huhn, R.D.7
Song, W.8
Li, D.9
Sharp, L.L.10
-
147
-
-
84944453397
-
Kick-starting the cancer-immunity cycle by targeting CD40
-
26140231,. PMID
-
Ellmark P, Mangsbo SM, Furebring C, Totterman TH, Norlen P. Kick-starting the cancer-immunity cycle by targeting CD40. Oncoimmunology. 2015;4:e1011484. doi:10.1080/2162402X.2015.1011484. PMID:26140231
-
(2015)
Oncoimmunology
, vol.4
, pp. 1011484
-
-
Ellmark, P.1
Mangsbo, S.M.2
Furebring, C.3
Totterman, T.H.4
Norlen, P.5
-
148
-
-
79551524395
-
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes
-
21266358, et al.,. PMID
-
Palazon A, Teijeira A, Martinez-Forero I, Hervas-Stubbs S, Roncal C, Penuelas I, Dubrot J, Morales-Kastresana A, Perez-Gracia JL, Ochoa MC, et al. Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res. 2011;71:801-11. doi:10.1158/0008-5472.CAN-10-1733. PMID:21266358
-
(2011)
Cancer Res
, vol.71
, pp. 801-811
-
-
Palazon, A.1
Teijeira, A.2
Martinez-Forero, I.3
Hervas-Stubbs, S.4
Roncal, C.5
Penuelas, I.6
Dubrot, J.7
Morales-Kastresana, A.8
Perez-Gracia, J.L.9
Ochoa, M.C.10
-
149
-
-
77958167235
-
Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
-
20616215, et al.,. PMID
-
Horton HM, Bernett MJ, Peipp M, Pong E, Karki S, Chu SY, Richards JO, Chen H, Repp R, Desjarlais JR, et al. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. Blood. 2010;116:3004-12. doi:10.1182/blood-2010-01-265280. PMID:20616215
-
(2010)
Blood
, vol.116
, pp. 3004-3012
-
-
Horton, H.M.1
Bernett, M.J.2
Peipp, M.3
Pong, E.4
Karki, S.5
Chu, S.Y.6
Richards, J.O.7
Chen, H.8
Repp, R.9
Desjarlais, J.R.10
-
150
-
-
84976493966
-
Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcgammaR Engagement
-
27265505,. PMID
-
Dahan R, Barnhart BC, Li F, Yamniuk AP, Korman AJ, Ravetch JV. Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcgammaR Engagement. Cancer Cell. 2016;29:820-31. doi:10.1016/j.ccell.2016.05.001. PMID:27265505
-
(2016)
Cancer Cell
, vol.29
, pp. 820-831
-
-
Dahan, R.1
Barnhart, B.C.2
Li, F.3
Yamniuk, A.P.4
Korman, A.J.5
Ravetch, J.V.6
-
151
-
-
80051885494
-
Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies
-
21852502,. PMID
-
Li F, Ravetch JV. Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science. 2011;333:1030-4. doi:10.1126/science.1206954. PMID:21852502
-
(2011)
Science
, vol.333
, pp. 1030-1034
-
-
Li, F.1
Ravetch, J.V.2
-
152
-
-
84983781360
-
Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity
-
27757306,. PMID
-
Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA. Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity. Oncoimmunology. 2016;5:e1211221. doi:10.1080/2162402X.2016.1211221. PMID:27757306
-
(2016)
Oncoimmunology
, vol.5
, pp. 1211221
-
-
Dubrovsky, L.1
Brea, E.J.2
Pankov, D.3
Casey, E.4
Dao, T.5
Liu, C.6
Scheinberg, D.A.7
-
153
-
-
84888357068
-
Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo
-
24218606,. PMID
-
Li F, Ravetch JV. Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. Proc Natl Acad Sci U S A. 2013;110:19501-6. doi:10.1073/pnas.1319502110. PMID:24218606
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 19501-19506
-
-
Li, F.1
Ravetch, J.V.2
-
154
-
-
84994107345
-
Neuroblastoma patients with high-affinity FCGR2A, -3A and stimulatory KIR 2DS2 treated by long-term infusion of anti-GD2 antibody ch14.18/CHO show higher ADCC levels and improved event-free survival
-
27999754,. PMID
-
Siebert N, Jensen C, Troschke-Meurer S, Zumpe M, Juttner M, Ehlert K, Kietz S, Muller I, Lode HN. Neuroblastoma patients with high-affinity FCGR2A, -3A and stimulatory KIR 2DS2 treated by long-term infusion of anti-GD2 antibody ch14.18/CHO show higher ADCC levels and improved event-free survival. Oncoimmunology. 2016;5:e1235108. doi:10.1080/2162402X.2016.1235108. PMID:27999754
-
(2016)
Oncoimmunology
, vol.5
, pp. 1235108
-
-
Siebert, N.1
Jensen, C.2
Troschke-Meurer, S.3
Zumpe, M.4
Juttner, M.5
Ehlert, K.6
Kietz, S.7
Muller, I.8
Lode, H.N.9
-
155
-
-
84961938333
-
Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions
-
26138698,. PMID
-
DiLillo DJ, Ravetch JV. Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions. Cancer Immunol Res. 2015;3:704-13. doi:10.1158/2326-6066.CIR-15-0120. PMID:26138698
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 704-713
-
-
DiLillo, D.J.1
Ravetch, J.V.2
-
156
-
-
84922189761
-
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies
-
25500122, et al.,. PMID
-
White AL, Chan HT, French RR, Willoughby J, Mockridge CI, Roghanian A, Penfold CA, Booth SG, Dodhy A, Polak ME, et al. Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies. Cancer Cell. 2015;27:138-48. doi:10.1016/j.ccell.2014.11.001. PMID:25500122
-
(2015)
Cancer Cell
, vol.27
, pp. 138-148
-
-
White, A.L.1
Chan, H.T.2
French, R.R.3
Willoughby, J.4
Mockridge, C.I.5
Roghanian, A.6
Penfold, C.A.7
Booth, S.G.8
Dodhy, A.9
Polak, M.E.10
-
157
-
-
84877822833
-
FcgammaRIotaIotaB controls the potency of agonistic anti-TNFR mAbs
-
23543215,. PMID
-
White AL, Chan HT, French RR, Beers SA, Cragg MS, Johnson PW, Glennie MJ. FcgammaRIotaIotaB controls the potency of agonistic anti-TNFR mAbs. Cancer Immunol Immunother. 2013;62:941-8. doi:10.1007/s00262-013-1398-6. PMID:23543215
-
(2013)
Cancer Immunol Immunother
, vol.62
, pp. 941-948
-
-
White, A.L.1
Chan, H.T.2
French, R.R.3
Beers, S.A.4
Cragg, M.S.5
Johnson, P.W.6
Glennie, M.J.7
-
158
-
-
80051925907
-
Interaction with FcgammaRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody
-
21742972, et al.,. PMID
-
White AL, Chan HT, Roghanian A, French RR, Mockridge CI, Tutt AL, Dixon SV, Ajona D, Verbeek JS, Al-Shamkhani A, et al. Interaction with FcgammaRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody. J Immunol. 2011;187:1754-63. doi:10.4049/jimmunol.1101135. PMID:21742972
-
(2011)
J Immunol
, vol.187
, pp. 1754-1763
-
-
White, A.L.1
Chan, H.T.2
Roghanian, A.3
French, R.R.4
Mockridge, C.I.5
Tutt, A.L.6
Dixon, S.V.7
Ajona, D.8
Verbeek, J.S.9
Al-Shamkhani, A.10
-
159
-
-
84905992571
-
Fcgamma receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization
-
25024386, et al.,. PMID
-
White AL, Dou L, Chan HT, Field VL, Mockridge CI, Moss K, Williams EL, Booth SG, French RR, Potter EA, et al. Fcgamma receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization. J Immunol. 2014;193:1828-35. doi:10.4049/jimmunol.1303204. PMID:25024386
-
(2014)
J Immunol
, vol.193
, pp. 1828-1835
-
-
White, A.L.1
Dou, L.2
Chan, H.T.3
Field, V.L.4
Mockridge, C.I.5
Moss, K.6
Williams, E.L.7
Booth, S.G.8
French, R.R.9
Potter, E.A.10
-
160
-
-
33645971964
-
Clinical medicine. Accident prompts a closer look at antibody trials
-
Marshall E. Clinical medicine. Accident prompts a closer look at antibody trials. Science. 2006;312:172.
-
(2006)
Science
, vol.312
, pp. 172
-
-
Marshall, E.1
-
161
-
-
84860257860
-
The storm has cleared: lessons from the CD28 superagonist TGN1412 trial
-
22487653,. PMID
-
Hunig T. The storm has cleared: lessons from the CD28 superagonist TGN1412 trial. Nat Rev Immunol. 2012;12:317-8. doi:10.1038/nri3192-c2. PMID:22487653
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 317-318
-
-
Hunig, T.1
-
162
-
-
33744991740
-
TGN1412: scrutinizing preclinical trials of antibody-based medicines
-
16710395,. PMID
-
Hansen S, Leslie RG. TGN1412: scrutinizing preclinical trials of antibody-based medicines. Nature. 2006;441:282. doi:10.1038/441282a. PMID:16710395
-
(2006)
Nature
, vol.441
, pp. 282
-
-
Hansen, S.1
Leslie, R.G.2
-
163
-
-
33646555791
-
TGN1412–a regulator's perspective
-
16680120,. PMID
-
Schneider CK, Kalinke U, Lower J. TGN1412–a regulator's perspective. Nat Biotechnol. 2006;24:493-6. doi:10.1038/nbt0506-493. PMID:16680120
-
(2006)
Nat Biotechnol
, vol.24
, pp. 493-496
-
-
Schneider, C.K.1
Kalinke, U.2
Lower, J.3
-
164
-
-
33646379402
-
Injury to research volunteers–the clinical-research nightmare
-
16672696,. PMID
-
Wood AJ, Darbyshire J. Injury to research volunteers–the clinical-research nightmare. N Engl J Med. 2006;354:1869-71. doi:10.1056/NEJMp068082. PMID:16672696
-
(2006)
N Engl J Med
, vol.354
, pp. 1869-1871
-
-
Wood, A.J.1
Darbyshire, J.2
-
165
-
-
84988028167
-
The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account
-
27191544,. PMID
-
Hunig T. The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account. Febs j. 2016;283:3325-34. doi:10.1111/febs.13754. PMID:27191544
-
(2016)
Febs j
, vol.283
, pp. 3325-3334
-
-
Hunig, T.1
-
166
-
-
84984801011
-
From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis
-
27586803,. PMID
-
Tyrsin D, Chuvpilo S, Matskevich A, Nemenov D, Romer PS, Tabares P, Hunig T. From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2016;34:45-8. PMID:27586803
-
(2016)
Clin Exp Rheumatol
, vol.34
, pp. 45-48
-
-
Tyrsin, D.1
Chuvpilo, S.2
Matskevich, A.3
Nemenov, D.4
Romer, P.S.5
Tabares, P.6
Hunig, T.7
-
167
-
-
84949532906
-
Experimental drug that injured UK volunteers resumes in human trials
-
25838401,. PMID
-
Dyer O. Experimental drug that injured UK volunteers resumes in human trials. Bmj. 2015;350:h1831. doi:10.1136/bmj.h1831. PMID:25838401
-
(2015)
Bmj
, vol.350
, pp. h1831
-
-
Dyer, O.1
-
168
-
-
84959386440
-
Trial Watch-Immunostimulation with cytokines in cancer therapy
-
27057468, et al.,. PMID
-
Vacchelli E, Aranda F, Bloy N, Buque A, Cremer I, Eggermont A, Fridman WH, Fucikova J, Galon J, Spisek R, et al. Trial Watch-Immunostimulation with cytokines in cancer therapy. Oncoimmunology. 2016;5:e1115942. doi:10.1080/2162402X.2015.1115942. PMID:27057468
-
(2016)
Oncoimmunology
, vol.5
, pp. 1115942
-
-
Vacchelli, E.1
Aranda, F.2
Bloy, N.3
Buque, A.4
Cremer, I.5
Eggermont, A.6
Fridman, W.H.7
Fucikova, J.8
Galon, J.9
Spisek, R.10
-
169
-
-
84944462911
-
Trial watch: Naked and vectored DNA-based anticancer vaccines
-
26155408, et al.,. PMID
-
Bloy N, Buque A, Aranda F, Castoldi F, Eggermont A, Cremer I, Sautes-Fridman C, Fucikova J, Galon J, Spisek R, et al. Trial watch: Naked and vectored DNA-based anticancer vaccines. Oncoimmunology. 2015;4:e1026531. doi:10.1080/2162402X.2015.1026531. PMID:26155408
-
(2015)
Oncoimmunology
, vol.4
, pp. 1026531
-
-
Bloy, N.1
Buque, A.2
Aranda, F.3
Castoldi, F.4
Eggermont, A.5
Cremer, I.6
Sautes-Fridman, C.7
Fucikova, J.8
Galon, J.9
Spisek, R.10
-
170
-
-
84938356701
-
Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment
-
25623164,. PMID
-
Zippelius A, Schreiner J, Herzig P, Muller P. Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment. Cancer Immunol Res. 2015;3:236-44. doi:10.1158/2326-6066.CIR-14-0226. PMID:25623164
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 236-244
-
-
Zippelius, A.1
Schreiner, J.2
Herzig, P.3
Muller, P.4
-
171
-
-
84995693608
-
Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor
-
27634762,. PMID
-
Ngiow SF, Young A, Blake SJ, Hill GR, Yagita H, Teng MW, Korman AJ, Smyth MJ. Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor. Cancer Res. 2016;76:6266-77. doi:10.1158/0008-5472.CAN-16-2141. PMID:27634762
-
(2016)
Cancer Res
, vol.76
, pp. 6266-6277
-
-
Ngiow, S.F.1
Young, A.2
Blake, S.J.3
Hill, G.R.4
Yagita, H.5
Teng, M.W.6
Korman, A.J.7
Smyth, M.J.8
-
172
-
-
84919632874
-
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence
-
25404365, et al.,. PMID
-
Buchan S, Manzo T, Flutter B, Rogel A, Edwards N, Zhang L, Sivakumaran S, Ghorashian S, Carpenter B, Bennett C, et al. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. J Immunol. 2015;194:125-33. doi:10.4049/jimmunol.1401644. PMID:25404365
-
(2015)
J Immunol
, vol.194
, pp. 125-133
-
-
Buchan, S.1
Manzo, T.2
Flutter, B.3
Rogel, A.4
Edwards, N.5
Zhang, L.6
Sivakumaran, S.7
Ghorashian, S.8
Carpenter, B.9
Bennett, C.10
-
173
-
-
84954053287
-
Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells
-
26493961, et al.,. PMID
-
Sanchez-Paulete AR, Cueto FJ, Martinez-Lopez M, Labiano S, Morales-Kastresana A, Rodriguez-Ruiz ME, Jure-Kunkel M, Azpilikueta A, Aznar MA, Quetglas JI, et al. Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells. Cancer Discov. 2016;6:71-9. doi:10.1158/2159-8290.CD-15-0510. PMID:26493961
-
(2016)
Cancer Discov
, vol.6
, pp. 71-79
-
-
Sanchez-Paulete, A.R.1
Cueto, F.J.2
Martinez-Lopez, M.3
Labiano, S.4
Morales-Kastresana, A.5
Rodriguez-Ruiz, M.E.6
Jure-Kunkel, M.7
Azpilikueta, A.8
Aznar, M.A.9
Quetglas, J.I.10
-
174
-
-
85016119137
-
Therapeutic Efficacy of 4-1BB Costimulation Is Abrogated by PD-1 Blockade in a Model of Spontaneous B-cell Lymphoma
-
28115358,. PMID
-
McKee SJ, Doff BL, Soon MS, Mattarollo SR. Therapeutic Efficacy of 4-1BB Costimulation Is Abrogated by PD-1 Blockade in a Model of Spontaneous B-cell Lymphoma. Cancer Immunol Res. 2017;5:191-7. doi:10.1158/2326-6066.CIR-16-0249. PMID:28115358
-
(2017)
Cancer Immunol Res
, vol.5
, pp. 191-197
-
-
McKee, S.J.1
Doff, B.L.2
Soon, M.S.3
Mattarollo, S.R.4
-
175
-
-
85017108448
-
Targeted agents and immunotherapies: optimizing outcomes in melanoma
-
28374786,. PMID
-
Luke JJ, Flaherty KT, Ribas A, Long GV. Targeted agents and immunotherapies: optimizing outcomes in melanoma. Nat Rev Clin Oncol. 2017;14:463-82. doi:10.1038/nrclinonc.2017.43. PMID:28374786
-
(2017)
Nat Rev Clin Oncol
, vol.14
, pp. 463-482
-
-
Luke, J.J.1
Flaherty, K.T.2
Ribas, A.3
Long, G.V.4
-
176
-
-
84959060166
-
Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
-
26855028,. PMID
-
Ryan JM, Wasser JS, Adler AJ, Vella AT. Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Expert Opin Biol Ther. 2016;16:655-74. doi:10.1517/14712598.2016.1152256. PMID:26855028
-
(2016)
Expert Opin Biol Ther
, vol.16
, pp. 655-674
-
-
Ryan, J.M.1
Wasser, J.S.2
Adler, A.J.3
Vella, A.T.4
-
177
-
-
84928811075
-
The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T-cell-dependent tumor immunity
-
25316820,. PMID
-
Mangsbo SM, Broos S, Fletcher E, Veitonmaki N, Furebring C, Dahlen E, Norlen P, Lindstedt M, Totterman TH, Ellmark P. The human agonistic CD40 antibody ADC-1013 eradicates bladder tumors and generates T-cell-dependent tumor immunity. Clin Cancer Res. 2015;21:1115-26. doi:10.1158/1078-0432.CCR-14-0913. PMID:25316820
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1115-1126
-
-
Mangsbo, S.M.1
Broos, S.2
Fletcher, E.3
Veitonmaki, N.4
Furebring, C.5
Dahlen, E.6
Norlen, P.7
Lindstedt, M.8
Totterman, T.H.9
Ellmark, P.10
-
178
-
-
84929469144
-
Immunomodulatory antibody therapy of cancer: the closer, the better
-
25351746,. PMID
-
Dronca RS, Dong H. Immunomodulatory antibody therapy of cancer: the closer, the better. Clin Cancer Res. 2015;21:944-6. doi:10.1158/1078-0432.CCR-14-2111. PMID:25351746
-
(2015)
Clin Cancer Res
, vol.21
, pp. 944-946
-
-
Dronca, R.S.1
Dong, H.2
-
179
-
-
84944474622
-
Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma
-
26155388,. PMID
-
Combe P, de Guillebon E, Thibault C, Granier C, Tartour E, Oudard S. Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma. Oncoimmunology. 2015;4:e1001236. doi:10.1080/2162402X.2014.1001236. PMID:26155388
-
(2015)
Oncoimmunology
, vol.4
, pp. 1001236
-
-
Combe, P.1
de Guillebon, E.2
Thibault, C.3
Granier, C.4
Tartour, E.5
Oudard, S.6
-
180
-
-
84921518859
-
Dendritic cell-targeted vaccines–hope or hype?
-
25190285,. PMID
-
Kastenmuller W, Kastenmuller K, Kurts C, Seder RA. Dendritic cell-targeted vaccines–hope or hype? Nat Rev Immunol. 2014;14:705-11. doi:10.1038/nri3727. PMID:25190285
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 705-711
-
-
Kastenmuller, W.1
Kastenmuller, K.2
Kurts, C.3
Seder, R.A.4
-
181
-
-
85047692172
-
Therapeutic vaccines for cancer: an overview of clinical trials
-
25001465, et al.,. PMID
-
Melero I, Gaudernack G, Gerritsen W, Huber C, Parmiani G, Scholl S, Thatcher N, Wagstaff J, Zielinski C, Faulkner I, et al. Therapeutic vaccines for cancer: an overview of clinical trials. Nat Rev Clin Oncol. 2014;11:509-24. doi:10.1038/nrclinonc.2014.111. PMID:25001465
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 509-524
-
-
Melero, I.1
Gaudernack, G.2
Gerritsen, W.3
Huber, C.4
Parmiani, G.5
Scholl, S.6
Thatcher, N.7
Wagstaff, J.8
Zielinski, C.9
Faulkner, I.10
-
182
-
-
84989271235
-
The cancer vaccine resurgence
-
27681782,. PMID
-
Mullard A. The cancer vaccine resurgence. Nat Rev Drug Discov. 2016;15:663-5. doi:10.1038/nrd.2016.201. PMID:27681782
-
(2016)
Nat Rev Drug Discov
, vol.15
, pp. 663-665
-
-
Mullard, A.1
-
183
-
-
84960372950
-
Vaccines for established cancer: overcoming the challenges posed by immune evasion
-
26965076,. PMID
-
van der Burg SH, Arens R, Ossendorp F, van Hall T, Melief CJ. Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nat Rev Cancer. 2016;16:219-33. doi:10.1038/nrc.2016.16. PMID:26965076
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 219-233
-
-
van der Burg, S.H.1
Arens, R.2
Ossendorp, F.3
van Hall, T.4
Melief, C.J.5
-
184
-
-
85020013827
-
Vaccine-based immunotherapeutic approaches to gliomas and beyond
-
28497804,. PMID
-
Weller M, Roth P, Preusser M, Wick W, Reardon DA, Platten M, Sampson JH. Vaccine-based immunotherapeutic approaches to gliomas and beyond. Nat Rev Neurol. 2017;13:363-74. doi:10.1038/nrneurol.2017.64. PMID:28497804
-
(2017)
Nat Rev Neurol
, vol.13
, pp. 363-374
-
-
Weller, M.1
Roth, P.2
Preusser, M.3
Wick, W.4
Reardon, D.A.5
Platten, M.6
Sampson, J.H.7
-
185
-
-
34548180389
-
Heat-shock protein-peptide complex-96 for the treatment of cancer
-
17696824,. PMID
-
Amato RJ. Heat-shock protein-peptide complex-96 for the treatment of cancer. Expert Opin Biol Ther. 2007;7:1267-73. doi:10.1517/14712598.7.8.1267. PMID:17696824
-
(2007)
Expert Opin Biol Ther
, vol.7
, pp. 1267-1273
-
-
Amato, R.J.1
-
186
-
-
79960406242
-
Human tumor cells killed by anthracyclines induce a tumor-specific immune response
-
21602432,. PMID
-
Fucikova J, Kralikova P, Fialova A, Brtnicky T, Rob L, Bartunkova J, Spisek R. Human tumor cells killed by anthracyclines induce a tumor-specific immune response. Cancer Res. 2011;71:4821-33. doi:10.1158/0008-5472.CAN-11-0950. PMID:21602432
-
(2011)
Cancer Res
, vol.71
, pp. 4821-4833
-
-
Fucikova, J.1
Kralikova, P.2
Fialova, A.3
Brtnicky, T.4
Rob, L.5
Bartunkova, J.6
Spisek, R.7
-
187
-
-
34249650184
-
Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications
-
17299090,. PMID
-
Spisek R, Charalambous A, Mazumder A, Vesole DH, Jagannath S, Dhodapkar MV. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood. 2007;109:4839-45. doi:10.1182/blood-2006-10-054221. PMID:17299090
-
(2007)
Blood
, vol.109
, pp. 4839-4845
-
-
Spisek, R.1
Charalambous, A.2
Mazumder, A.3
Vesole, D.H.4
Jagannath, S.5
Dhodapkar, M.V.6
-
188
-
-
34548271716
-
Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells
-
17721082,. PMID
-
Spisek R, Dhodapkar MV. Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells. Cell Cycle. 2007;6:1962-5. doi:10.4161/cc.6.16.4601. PMID:17721082
-
(2007)
Cell Cycle
, vol.6
, pp. 1962-1965
-
-
Spisek, R.1
Dhodapkar, M.V.2
-
189
-
-
84978196961
-
GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development
-
26916005,. PMID
-
Wu BX, Hong F, Zhang Y, Ansa-Addo E, Li Z. GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development. Adv Cancer Res. 2016;129:165-90. doi:10.1016/bs.acr.2015.09.001. PMID:26916005
-
(2016)
Adv Cancer Res
, vol.129
, pp. 165-190
-
-
Wu, B.X.1
Hong, F.2
Zhang, Y.3
Ansa-Addo, E.4
Li, Z.5
-
190
-
-
85016040815
-
Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination
-
27364122,. PMID
-
Fromm G, de Silva S, Giffin L, Xu X, Rose J, Schreiber TH. Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination. Cancer Immunol Res. 2016;4:766-78. doi:10.1158/2326-6066.CIR-15-0228. PMID:27364122
-
(2016)
Cancer Immunol Res
, vol.4
, pp. 766-778
-
-
Fromm, G.1
de Silva, S.2
Giffin, L.3
Xu, X.4
Rose, J.5
Schreiber, T.H.6
-
191
-
-
85019607829
-
Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist alpha-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity
-
28680744,. PMID
-
Liu Z, Hao X, Zhang Y, Zhang J, Carey CD, Falo LD, Jr., Storkus WJ, You Z. Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist alpha-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity. Oncoimmunology. 2017;6:e1315487. doi:10.1080/2162402X.2017.1315487. PMID:28680744
-
(2017)
Oncoimmunology
, vol.6
, pp. 1315487
-
-
Liu, Z.1
Hao, X.2
Zhang, Y.3
Zhang, J.4
Carey, C.D.5
Falo, L.D.6
Storkus, W.J.7
You, Z.8
-
192
-
-
84954515793
-
Reducing toxicity of 4-1BB costimulation: targeting 4-1BB ligands to the tumor stroma with bi-specific aptamer conjugates
-
25949891,. PMID
-
Schrand B, Berezhnoy A, Brenneman R, Williams A, Levay A, Gilboa E. Reducing toxicity of 4-1BB costimulation: targeting 4-1BB ligands to the tumor stroma with bi-specific aptamer conjugates. Oncoimmunology. 2015;4:e970918. doi:10.4161/21624011.2014.970918. PMID:25949891
-
(2015)
Oncoimmunology
, vol.4
, pp. 970918
-
-
Schrand, B.1
Berezhnoy, A.2
Brenneman, R.3
Williams, A.4
Levay, A.5
Gilboa, E.6
-
193
-
-
84954412874
-
Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors
-
26942084,. PMID
-
Yelamos J, Galindo M, Navarro J, Albanell J, Rovira A, Rojo F, Oliver J. Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors. Oncoimmunology. 2016;5:e1065370. doi:10.1080/2162402X.2015.1065370. PMID:26942084
-
(2016)
Oncoimmunology
, vol.5
, pp. 1065370
-
-
Yelamos, J.1
Galindo, M.2
Navarro, J.3
Albanell, J.4
Rovira, A.5
Rojo, F.6
Oliver, J.7
-
194
-
-
84979698228
-
Mechanisms and regulation of endothelial VEGF receptor signalling
-
27461391,. PMID
-
Simons M, Gordon E, Claesson-Welsh L. Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol. 2016;17:611-25. doi:10.1038/nrm.2016.87. PMID:27461391
-
(2016)
Nat Rev Mol Cell Biol
, vol.17
, pp. 611-625
-
-
Simons, M.1
Gordon, E.2
Claesson-Welsh, L.3
-
195
-
-
84954569855
-
Ten years of anti-vascular endothelial growth factor therapy
-
26775688,. PMID
-
Ferrara N, Adamis AP. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016;15:385-403. doi:10.1038/nrd.2015.17. PMID:26775688
-
(2016)
Nat Rev Drug Discov
, vol.15
, pp. 385-403
-
-
Ferrara, N.1
Adamis, A.P.2
-
196
-
-
84933050304
-
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
-
26105538,. PMID
-
Barker HE, Paget JT, Khan AA, Harrington KJ. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer. 2015;15:409-25. doi:10.1038/nrc3958. PMID:26105538
-
(2015)
Nat Rev Cancer
, vol.15
, pp. 409-425
-
-
Barker, H.E.1
Paget, J.T.2
Khan, A.A.3
Harrington, K.J.4
-
197
-
-
85017268441
-
Barriers to Radiation-Induced In Situ Tumor Vaccination
-
28348554,. PMID
-
Wennerberg E, Lhuillier C, Vanpouille-Box C, Pilones KA, Garcia-Martinez E, Rudqvist NP, Formenti SC, Demaria S. Barriers to Radiation-Induced In Situ Tumor Vaccination. Front Immunol. 2017;8:229. doi:10.3389/fimmu.2017.00229. PMID:28348554
-
(2017)
Front Immunol
, vol.8
, pp. 229
-
-
Wennerberg, E.1
Lhuillier, C.2
Vanpouille-Box, C.3
Pilones, K.A.4
Garcia-Martinez, E.5
Rudqvist, N.P.6
Formenti, S.C.7
Demaria, S.8
-
198
-
-
84997497897
-
Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking?
-
27190630,. PMID
-
Demaria S, Formenti SC. Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking? J Immunother Cancer. 2016;4:29. doi:10.1186/s40425-016-0133-1. PMID:27190630
-
(2016)
J Immunother Cancer
, vol.4
, pp. 29
-
-
Demaria, S.1
Formenti, S.C.2
-
199
-
-
84937525789
-
Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
-
26095785, et al.,. PMID
-
Golden EB, Chhabra A, Chachoua A, Adams S, Donach M, Fenton-Kerimian M, Friedman K, Ponzo F, Babb JS, Goldberg J, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol. 2015;16:795-803. PMID:26095785
-
(2015)
Lancet Oncol
, vol.16
, pp. 795-803
-
-
Golden, E.B.1
Chhabra, A.2
Chachoua, A.3
Adams, S.4
Donach, M.5
Fenton-Kerimian, M.6
Friedman, K.7
Ponzo, F.8
Babb, J.S.9
Goldberg, J.10
-
200
-
-
84919475564
-
Combination of radiotherapy and immune checkpoint inhibitors
-
25481263,. PMID
-
Pilones KA, Vanpouille-Box C, Demaria S. Combination of radiotherapy and immune checkpoint inhibitors. Semin Radiat Oncol. 2015;25:28-33. PMID:25481263
-
(2015)
Semin Radiat Oncol
, vol.25
, pp. 28-33
-
-
Pilones, K.A.1
Vanpouille-Box, C.2
Demaria, S.3
-
201
-
-
85015955711
-
Radiation-Induced Enhancement of Antitumor T-cell Immunity by VEGF-Targeted 4-1BB Costimulation
-
28082399, et al.,. PMID
-
Schrand B, Verma B, Levay A, Patel S, Castro I, Benaduce AP, Brenneman R, Umland O, Yagita H, Gilboa E, et al. Radiation-Induced Enhancement of Antitumor T-cell Immunity by VEGF-Targeted 4-1BB Costimulation. Cancer Res. 2017;77:1310-21. PMID:28082399
-
(2017)
Cancer Res
, vol.77
, pp. 1310-1321
-
-
Schrand, B.1
Verma, B.2
Levay, A.3
Patel, S.4
Castro, I.5
Benaduce, A.P.6
Brenneman, R.7
Umland, O.8
Yagita, H.9
Gilboa, E.10
-
202
-
-
84964314436
-
Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy
-
24938283,. PMID
-
Schrand B, Berezhnoy A, Brenneman R, Williams A, Levay A, Kong LY, Rao G, Zhou S, Heimberger AB, Gilboa E. Targeting 4-1BB costimulation to the tumor stroma with bispecific aptamer conjugates enhances the therapeutic index of tumor immunotherapy. Cancer Immunol Res. 2014;2:867-77. PMID:24938283
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 867-877
-
-
Schrand, B.1
Berezhnoy, A.2
Brenneman, R.3
Williams, A.4
Levay, A.5
Kong, L.Y.6
Rao, G.7
Zhou, S.8
Heimberger, A.B.9
Gilboa, E.10
-
203
-
-
85021749676
-
Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors
-
28463630, et al.,. PMID
-
Burris HA, Infante JR, Ansell SM, Nemunaitis JJ, Weiss GR, Villalobos VM, Sikic BI, Taylor MH, Northfelt DW, Carson WE, 3rd, et al. Safety and Activity of Varlilumab, a Novel and First-in-Class Agonist Anti-CD27 Antibody, in Patients With Advanced Solid Tumors. J Clin Oncol. 2017;35:2028-36. PMID:28463630
-
(2017)
J Clin Oncol
, vol.35
, pp. 2028-2036
-
-
Burris, H.A.1
Infante, J.R.2
Ansell, S.M.3
Nemunaitis, J.J.4
Weiss, G.R.5
Villalobos, V.M.6
Sikic, B.I.7
Taylor, M.H.8
Northfelt, D.W.9
Carson, W.E.10
-
204
-
-
85027297483
-
Abstract CT023: Phase I results from the combination of an immune-activating anti-CD27 antibody (varlilumab) in combination with PD-1 blockade (nivolumab): activation across multiple immune pathways without untoward immune-related adverse events
-
et al
-
Sanborn RE, Pishvain MJ, Callahan MK, Rizvi N, Kluger H, Yellin M, Rawls T, Vitale L, Halim A, Davis T, et al. Abstract CT023: Phase I results from the combination of an immune-activating anti-CD27 antibody (varlilumab) in combination with PD-1 blockade (nivolumab): activation across multiple immune pathways without untoward immune-related adverse events. Cancer Research. 2016;76:CT023.
-
(2016)
Cancer Research
, vol.76
, pp. CT023
-
-
Sanborn, R.E.1
Pishvain, M.J.2
Callahan, M.K.3
Rizvi, N.4
Kluger, H.5
Yellin, M.6
Rawls, T.7
Vitale, L.8
Halim, A.9
Davis, T.10
-
205
-
-
84946068678
-
Dacetuzumab plus rituximab, ifosfamide, carboplatin and etoposide as salvage therapy for patients with diffuse large B-cell lymphoma relapsing after rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone: a randomized, double-blind, placebo-controlled phase 2b trial
-
25651427, et al.,. PMID
-
Fayad L, Ansell SM, Advani R, Coiffier B, Stuart R, Bartlett NL, Forero-Torres A, Kuliczkowski K, Belada D, Ng E, et al. Dacetuzumab plus rituximab, ifosfamide, carboplatin and etoposide as salvage therapy for patients with diffuse large B-cell lymphoma relapsing after rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone: a randomized, double-blind, placebo-controlled phase 2b trial. Leuk Lymphoma. 2015;56:2569-78. PMID:25651427
-
(2015)
Leuk Lymphoma
, vol.56
, pp. 2569-2578
-
-
Fayad, L.1
Ansell, S.M.2
Advani, R.3
Coiffier, B.4
Stuart, R.5
Bartlett, N.L.6
Forero-Torres, A.7
Kuliczkowski, K.8
Belada, D.9
Ng, E.10
-
206
-
-
84949936992
-
A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma
-
26386124, et al.,. PMID
-
Nowak AK, Cook AM, McDonnell AM, Millward MJ, Creaney J, Francis RJ, Hasani A, Segal A, Musk AW, Turlach BA, et al. A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma. Ann Oncol. 2015;26:2483-90. PMID:26386124
-
(2015)
Ann Oncol
, vol.26
, pp. 2483-2490
-
-
Nowak, A.K.1
Cook, A.M.2
McDonnell, A.M.3
Millward, M.J.4
Creaney, J.5
Francis, R.J.6
Hasani, A.7
Segal, A.8
Musk, A.W.9
Turlach, B.A.10
-
207
-
-
84951178450
-
Abstract CT137: Combination of agonistic CD40 monoclonal antibody CP-870,893 and anti-CTLA-4 antibody tremelimumab in patients with metastatic melanoma
-
et al
-
Bajor DL, Mick R, Riese MJ, Richman LP, Xu X, Torigian DA, Stelekati E, Sweeney M, Sullivan B, Schuchter LM, et al. Abstract CT137: Combination of agonistic CD40 monoclonal antibody CP-870,893 and anti-CTLA-4 antibody tremelimumab in patients with metastatic melanoma. Cancer Research. 2015;75:CT137.
-
(2015)
Cancer Research
, vol.75
, pp. CT137
-
-
Bajor, D.L.1
Mick, R.2
Riese, M.J.3
Richman, L.P.4
Xu, X.5
Torigian, D.A.6
Stelekati, E.7
Sweeney, M.8
Sullivan, B.9
Schuchter, L.M.10
-
208
-
-
84927615313
-
Clinical and biological effects of an agonist anti-CD40 antibody: a Cancer Research UK phase I study
-
25589626, et al.,. PMID
-
Johnson P, Challis R, Chowdhury F, Gao Y, Harvey M, Geldart T, Kerr P, Chan C, Smith A, Steven N, et al. Clinical and biological effects of an agonist anti-CD40 antibody: a Cancer Research UK phase I study. Clin Cancer Res. 2015;21:1321-8. doi:10.1158/1078-0432.CCR-14-2355. PMID:25589626
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1321-1328
-
-
Johnson, P.1
Challis, R.2
Chowdhury, F.3
Gao, Y.4
Harvey, M.5
Geldart, T.6
Kerr, P.7
Chan, C.8
Smith, A.9
Steven, N.10
-
209
-
-
85018841234
-
Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody
-
27756788, et al.,. PMID
-
Segal NH, Logan TF, Hodi FS, McDermott D, Melero I, Hamid O, Schmidt H, Robert C, Chiarion-Sileni V, Ascierto PA, et al. Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody. Clin Cancer Res. 2017;23:1929-36. doi:10.1158/1078-0432.CCR-16-1272. PMID:27756788
-
(2017)
Clin Cancer Res
, vol.23
, pp. 1929-1936
-
-
Segal, N.H.1
Logan, T.F.2
Hodi, F.S.3
McDermott, D.4
Melero, I.5
Hamid, O.6
Schmidt, H.7
Robert, C.8
Chiarion-Sileni, V.9
Ascierto, P.A.10
-
210
-
-
85029504106
-
Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors
-
Tolcher AW, Sznol M, Hu-Lieskovan S, Papadopoulos KP, Patnaik A, Rasco D, Di Gravio D, Huang B, Gambhire D, Chen Y, et al. Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017;in press. doi:10.1158/1078-0432.CCR-17-1243. PMID:28634283
-
(2017)
Clin Cancer Res
-
-
Tolcher, A.W.1
Sznol, M.2
Hu-Lieskovan, S.3
Papadopoulos, K.P.4
Patnaik, A.5
Rasco, D.6
Di Gravio, D.7
Huang, B.8
Gambhire, D.9
Chen, Y.10
-
211
-
-
84938353999
-
A phase I study of PF-05082566 (anti-4-1BB) + rituximab in patients with CD20+ NHL
-
et al
-
Gopal AK, Bartlett NL, Levy R, Houot R, Smith SD, Segal NH, Thall AD, Mugundu G, Huang B, Davis C, et al. A phase I study of PF-05082566 (anti-4-1BB) + rituximab in patients with CD20+ NHL. Journal of Clinical Oncology. 2015;33:3004.
-
(2015)
Journal of Clinical Oncology
, vol.33
, pp. 3004
-
-
Gopal, A.K.1
Bartlett, N.L.2
Levy, R.3
Houot, R.4
Smith, S.D.5
Segal, N.H.6
Thall, A.D.7
Mugundu, G.8
Huang, B.9
Davis, C.10
-
212
-
-
85036497908
-
Dose escalation results from a first-in-human, phase 1 study of the glucocorticoid-induced TNF receptor-related protein (GITR) agonist AMG 228 in patients (Pts) with advanced solid tumors
-
Tran B, Carvajal RD, Marabelle A, Patel SP, LoRusso P, Rasmussen E, Juan G, Upreti VV, Ngarmchamnanrith G, Schöffski P. Dose escalation results from a first-in-human, phase 1 study of the glucocorticoid-induced TNF receptor-related protein (GITR) agonist AMG 228 in patients (Pts) with advanced solid tumors. J Clin Oncol. 2017;35:2521.
-
(2017)
J Clin Oncol
, vol.35
, pp. 2521
-
-
Tran, B.1
Carvajal, R.D.2
Marabelle, A.3
Patel, S.P.4
LoRusso, P.5
Rasmussen, E.6
Juan, G.7
Upreti, V.V.8
Ngarmchamnanrith, G.9
Schöffski, P.10
-
213
-
-
84991236330
-
First-in-human phase 1 single-dose study of TRX-518, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody in adults with advanced solid tumors
-
Koon HB, Shepard DR, Merghoub T, Schaer DA, Sirard CA, Wolchok JD. First-in-human phase 1 single-dose study of TRX-518, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody in adults with advanced solid tumors. Journal of Clinical Oncology. 2016;34:3017.
-
(2016)
Journal of Clinical Oncology
, vol.34
, pp. 3017
-
-
Koon, H.B.1
Shepard, D.R.2
Merghoub, T.3
Schaer, D.A.4
Sirard, C.A.5
Wolchok, J.D.6
-
214
-
-
85027193113
-
Preliminary results of a phase I/IIa study of BMS-986156 (glucocorticoid-induced tumor necrosis factor receptor–related gene [GITR] agonist), alone and in combination with nivolumab in pts with advanced solid tumors
-
et al
-
Siu LL, Steeghs N, Meniawy T, Joerger M, Spratlin JL, Rottey S, Nagrial A, Cooper A, Meier R, Guan X, et al. Preliminary results of a phase I/IIa study of BMS-986156 (glucocorticoid-induced tumor necrosis factor receptor–related gene [GITR] agonist), alone and in combination with nivolumab in pts with advanced solid tumors. Journal of Clinical Oncology. 2017;35:104.
-
(2017)
Journal of Clinical Oncology
, vol.35
, pp. 104
-
-
Siu, L.L.1
Steeghs, N.2
Meniawy, T.3
Joerger, M.4
Spratlin, J.L.5
Rottey, S.6
Nagrial, A.7
Cooper, A.8
Meier, R.9
Guan, X.10
-
215
-
-
85036506131
-
Phase 1 safety of ICOS agonist antibody JTX-2011 alone and with nivolumab (nivo) in advanced solid tumors; predicted vs observed pharmacokinetics (PK) in ICONIC
-
et al
-
Burris HA, Callahan MK, Tolcher AW, Kummar S, Falchook GS, Pachynski RK, Tykodi SS, Gibney GT, Seiwert TY, Gainor JF, et al. Phase 1 safety of ICOS agonist antibody JTX-2011 alone and with nivolumab (nivo) in advanced solid tumors; predicted vs observed pharmacokinetics (PK) in ICONIC. J Clin Oncol. 2017;35:3033.
-
(2017)
J Clin Oncol
, vol.35
, pp. 3033
-
-
Burris, H.A.1
Callahan, M.K.2
Tolcher, A.W.3
Kummar, S.4
Falchook, G.S.5
Pachynski, R.K.6
Tykodi, S.S.7
Gibney, G.T.8
Seiwert, T.Y.9
Gainor, J.F.10
-
216
-
-
85036598136
-
The relationship of pharmacodynamics (PD) and pharmacokinetics (PK) to clinical outcomes in a phase I study of OX40 agonistic monoclonal antibody (mAb) PF-04518600 (PF-8600)
-
et al
-
El-Khoueiry AB, Hamid O, Thompson JA, Ros W, Eskens F, Doi T, Hu-Lieskovan S, Chou J, Liao K, Ganguly BJ, et al. The relationship of pharmacodynamics (PD) and pharmacokinetics (PK) to clinical outcomes in a phase I study of OX40 agonistic monoclonal antibody (mAb) PF-04518600 (PF-8600). Journal of Clinical Oncology. 2017;35:3027.
-
(2017)
Journal of Clinical Oncology
, vol.35
, pp. 3027
-
-
El-Khoueiry, A.B.1
Hamid, O.2
Thompson, J.A.3
Ros, W.4
Eskens, F.5
Doi, T.6
Hu-Lieskovan, S.7
Chou, J.8
Liao, K.9
Ganguly, B.J.10
-
217
-
-
84994678933
-
A phase Ib dose escalation study of the OX40 agonist MOXR0916 and the PD-L1 inhibitor atezolizumab in patients with advanced solid tumors
-
et al
-
Infante JR, Hansen AR, Pishvaian MJ, Chow LQM, McArthur GA, Bauer TM, Liu SV, Sandhu SK, Tsai FY-C, Kim J, et al. A phase Ib dose escalation study of the OX40 agonist MOXR0916 and the PD-L1 inhibitor atezolizumab in patients with advanced solid tumors. Journal of Clinical Oncology. 2016;34:101.
-
(2016)
Journal of Clinical Oncology
, vol.34
, pp. 101
-
-
Infante, J.R.1
Hansen, A.R.2
Pishvaian, M.J.3
Chow, L.Q.M.4
McArthur, G.A.5
Bauer, T.M.6
Liu, S.V.7
Sandhu, S.K.8
Tsai, F.Y.-C.9
Kim, J.10
-
218
-
-
85084273994
-
Phase 1 study of MEDI0562, a humanized OX40 agonist monoclonal antibody (mAb), in adult patients (pts) with advanced solid tumors
-
PD
-
Glisson BS, Leidner R, Ferris RL, Powderly J, Rizvi N, Norton JD, Burton J, Lanasa MC, Patel SP. Phase 1 study of MEDI0562, a humanized OX40 agonist monoclonal antibody (mAb), in adult patients (pts) with advanced solid tumors. Annals of Oncology. 2016;27:1052PD. doi:10.1093/annonc/mdw378.07.
-
(2016)
Annals of Oncology
, vol.27
, pp. 1052
-
-
Glisson, B.S.1
Leidner, R.2
Ferris, R.L.3
Powderly, J.4
Rizvi, N.5
Norton, J.D.6
Burton, J.7
Lanasa, M.C.8
Patel, S.P.9
-
219
-
-
84966771330
-
Targeting T Cell Co-receptors for Cancer Therapy
-
27192570,. PMID
-
Callahan MK, Postow MA, Wolchok JD. Targeting T Cell Co-receptors for Cancer Therapy. Immunity. 2016;44:1069-78. doi:10.1016/j.immuni.2016.04.023. PMID:27192570
-
(2016)
Immunity
, vol.44
, pp. 1069-1078
-
-
Callahan, M.K.1
Postow, M.A.2
Wolchok, J.D.3
-
220
-
-
85016724516
-
Cancer immunotherapies targeting the PD-1 signaling pathway
-
28376884,. PMID
-
Iwai Y, Hamanishi J, Chamoto K, Honjo T. Cancer immunotherapies targeting the PD-1 signaling pathway. J Biomed Sci. 2017;24:26. doi:10.1186/s12929-017-0329-9. PMID:28376884
-
(2017)
J Biomed Sci
, vol.24
, pp. 26
-
-
Iwai, Y.1
Hamanishi, J.2
Chamoto, K.3
Honjo, T.4
-
221
-
-
84944449557
-
Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma-An exclamation sign with a question mark
-
26140249,. PMID
-
Kroemer G, Galluzzi L. Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma-An exclamation sign with a question mark. Oncoimmunology. 2015;4:e1058037. doi:10.1080/2162402X.2015.1058037. PMID:26140249
-
(2015)
Oncoimmunology
, vol.4
, pp. 1058037
-
-
Kroemer, G.1
Galluzzi, L.2
-
222
-
-
84976535754
-
CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma
-
27471622,. PMID
-
Yu GT, Bu LL, Zhao YY, Mao L, Deng WW, Wu TF, Zhang WF, Sun ZJ. CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma. Oncoimmunology. 2016;5:e1151594. doi:10.1080/2162402X.2016.1151594. PMID:27471622
-
(2016)
Oncoimmunology
, vol.5
, pp. 1151594
-
-
Yu, G.T.1
Bu, L.L.2
Zhao, Y.Y.3
Mao, L.4
Deng, W.W.5
Wu, T.F.6
Zhang, W.F.7
Sun, Z.J.8
-
223
-
-
84938709400
-
Trial watch: Tumor-targeting monoclonal antibodies for oncological indications
-
25949870, et al.,. PMID
-
Vacchelli E, Pol J, Bloy N, Eggermont A, Cremer I, Fridman WH, Galon J, Marabelle A, Kohrt H, Zitvogel L, et al. Trial watch: Tumor-targeting monoclonal antibodies for oncological indications. Oncoimmunology. 2015;4:e985940. doi:10.4161/2162402X.2014.985940. PMID:25949870
-
(2015)
Oncoimmunology
, vol.4
, pp. 985940
-
-
Vacchelli, E.1
Pol, J.2
Bloy, N.3
Eggermont, A.4
Cremer, I.5
Fridman, W.H.6
Galon, J.7
Marabelle, A.8
Kohrt, H.9
Zitvogel, L.10
-
224
-
-
84942375939
-
Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy
-
26137404, et al.,. PMID
-
Pol J, Vacchelli E, Aranda F, Castoldi F, Eggermont A, Cremer I, Sautes-Fridman C, Fucikova J, Galon J, Spisek R, et al. Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy. Oncoimmunology. 2015;4:e1008866. doi:10.1080/2162402X.2015.1008866. PMID:26137404
-
(2015)
Oncoimmunology
, vol.4
, pp. 1008866
-
-
Pol, J.1
Vacchelli, E.2
Aranda, F.3
Castoldi, F.4
Eggermont, A.5
Cremer, I.6
Sautes-Fridman, C.7
Fucikova, J.8
Galon, J.9
Spisek, R.10
-
225
-
-
84978499806
-
Chemotherapy and immunotherapy: A close interplay to fight cancer?
-
27622046,. PMID
-
Hanoteau A, Moser M. Chemotherapy and immunotherapy: A close interplay to fight cancer? Oncoimmunology. 2016;5:e1190061. doi:10.1080/2162402X.2016.1190061. PMID:27622046
-
(2016)
Oncoimmunology
, vol.5
, pp. 1190061
-
-
Hanoteau, A.1
Moser, M.2
-
226
-
-
85036494969
-
Varlilumab Is Safe and Active in Patients with Advanced Solid Tumors
-
Varlilumab Is Safe and Active in Patients with Advanced Solid Tumors. Cancer Discov. 2017;7:OF9. doi:10.1158/2159-8290.CD-RW2017-089.
-
(2017)
Cancer Discov
, vol.7
, pp. OF9
-
-
-
227
-
-
84942944907
-
Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rgammanull Immunodeficient Mice
-
26113085, et al.,. PMID
-
Sanmamed MF, Rodriguez I, Schalper KA, Onate C, Azpilikueta A, Rodriguez-Ruiz ME, Morales-Kastresana A, Labiano S, Perez-Gracia JL, Martin-Algarra S, et al. Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rgammanull Immunodeficient Mice. Cancer Res. 2015;75:3466-78. doi:10.1158/0008-5472.CAN-14-3510. PMID:26113085
-
(2015)
Cancer Res
, vol.75
, pp. 3466-3478
-
-
Sanmamed, M.F.1
Rodriguez, I.2
Schalper, K.A.3
Onate, C.4
Azpilikueta, A.5
Rodriguez-Ruiz, M.E.6
Morales-Kastresana, A.7
Labiano, S.8
Perez-Gracia, J.L.9
Martin-Algarra, S.10
-
228
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
23724867, et al.,. PMID
-
Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, Segal NH, Ariyan CE, Gordon RA, Reed K, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013;369:122-33. doi:10.1056/NEJMoa1302369. PMID:23724867
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
Postow, M.A.4
Rizvi, N.A.5
Lesokhin, A.M.6
Segal, N.H.7
Ariyan, C.E.8
Gordon, R.A.9
Reed, K.10
-
229
-
-
78549256115
-
Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors
-
20855968,. PMID
-
Ruter J, Antonia SJ, Burris HA, Huhn RD, Vonderheide RH. Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors. Cancer Biol Ther. 2010;10:983-93. doi:10.4161/cbt.10.10.13251. PMID:20855968
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 983-993
-
-
Ruter, J.1
Antonia, S.J.2
Burris, H.A.3
Huhn, R.D.4
Vonderheide, R.H.5
-
230
-
-
33947506186
-
Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
-
17327609, et al.,. PMID
-
Vonderheide RH, Flaherty KT, Khalil M, Stumacher MS, Bajor DL, Hutnick NA, Sullivan P, Mahany JJ, Gallagher M, Kramer A, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol. 2007;25:876-83. doi:10.1200/JCO.2006.08.3311. PMID:17327609
-
(2007)
J Clin Oncol
, vol.25
, pp. 876-883
-
-
Vonderheide, R.H.1
Flaherty, K.T.2
Khalil, M.3
Stumacher, M.S.4
Bajor, D.L.5
Hutnick, N.A.6
Sullivan, P.7
Mahany, J.J.8
Gallagher, M.9
Kramer, A.10
-
231
-
-
77958045597
-
CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893
-
20842056, et al.,. PMID
-
Kalbasi A, Fonsatti E, Natali PG, Altomonte M, Bertocci E, Cutaia O, Calabro L, Chiou M, Tap W, Chmielowski B, et al. CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893. J Immunother. 2010;33:810-6. doi:10.1097/CJI.0b013e3181ee73a7. PMID:20842056
-
(2010)
J Immunother
, vol.33
, pp. 810-816
-
-
Kalbasi, A.1
Fonsatti, E.2
Natali, P.G.3
Altomonte, M.4
Bertocci, E.5
Cutaia, O.6
Calabro, L.7
Chiou, M.8
Tap, W.9
Chmielowski, B.10
-
232
-
-
70749083844
-
Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation
-
19906293,. PMID
-
Carpenter EL, Mick R, Ruter J, Vonderheide RH. Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation. J Transl Med. 2009;7:93. doi:10.1186/1479-5876-7-93. PMID:19906293
-
(2009)
J Transl Med
, vol.7
, pp. 93
-
-
Carpenter, E.L.1
Mick, R.2
Ruter, J.3
Vonderheide, R.H.4
-
233
-
-
85014362982
-
Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia
-
27913530,. PMID
-
Frey NV, Porter DL. Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program. 2016; 2016:567-72. PMID:27913530
-
(2016)
Hematology Am Soc Hematol Educ Program
, vol.2016
, pp. 567-572
-
-
Frey, N.V.1
Porter, D.L.2
-
234
-
-
84897568616
-
Managing cytokine release syndrome associated with novel T cell-engaging therapies
-
24667956,. PMID
-
Maude SL, Barrett D, Teachey DT, Grupp SA. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J. 2014;20:119-22. doi:10.1097/PPO.0000000000000035. PMID:24667956
-
(2014)
Cancer J
, vol.20
, pp. 119-122
-
-
Maude, S.L.1
Barrett, D.2
Teachey, D.T.3
Grupp, S.A.4
-
235
-
-
73849137192
-
Recent advances in the understanding of drug-mediated infusion reactions and cytokine release syndrome
-
20047153,. PMID
-
Walker M, Makropoulos D, Achuthanandam R, Bugelski PJ. Recent advances in the understanding of drug-mediated infusion reactions and cytokine release syndrome. Curr Opin Drug Discov Devel. 2010;13:124-35. PMID:20047153
-
(2010)
Curr Opin Drug Discov Devel
, vol.13
, pp. 124-135
-
-
Walker, M.1
Makropoulos, D.2
Achuthanandam, R.3
Bugelski, P.J.4
-
236
-
-
85018509133
-
New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
-
28407743,. PMID
-
Kroschinsky F, Stolzel F, von Bonin S, Beutel G, Kochanek M, Kiehl M, Schellongowski P, Intensive Care in H, Oncological Patients Collaborative G. New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management. Crit Care. 2017;21:89. doi:10.1186/s13054-017-1678-1. PMID:28407743
-
(2017)
Crit Care
, vol.21
, pp. 89
-
-
Kroschinsky, F.1
Stolzel, F.2
von Bonin, S.3
Beutel, G.4
Kochanek, M.5
Kiehl, M.6
Schellongowski, P.7
-
237
-
-
85024126192
-
The Use of Anti-CD40 mAb in Cancer
-
25651948,. PMID
-
Remer M, White A, Glennie M, Al-Shamkhani A, Johnson P. The Use of Anti-CD40 mAb in Cancer. Curr Top Microbiol Immunol. 2017;405:165-207. PMID:25651948
-
(2017)
Curr Top Microbiol Immunol
, vol.405
, pp. 165-207
-
-
Remer, M.1
White, A.2
Glennie, M.3
Al-Shamkhani, A.4
Johnson, P.5
-
238
-
-
84867896903
-
Transcriptional control of effector and memory CD8+ T cell differentiation
-
23080391,. PMID
-
Kaech SM, Cui W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol. 2012;12:749-61. doi:10.1038/nri3307. PMID:23080391
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 749-761
-
-
Kaech, S.M.1
Cui, W.2
-
239
-
-
84957442580
-
The multifaceted role of CD4(+) T cells in CD8(+) T cell memory
-
26781939,. PMID
-
Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol. 2016;16:102-11. doi:10.1038/nri.2015.10. PMID:26781939
-
(2016)
Nat Rev Immunol
, vol.16
, pp. 102-111
-
-
Laidlaw, B.J.1
Craft, J.E.2
Kaech, S.M.3
-
240
-
-
84957442891
-
Regulatory T cell memory
-
26688349,. PMID
-
Rosenblum MD, Way SS, Abbas AK. Regulatory T cell memory. Nat Rev Immunol. 2016;16:90-101. doi:10.1038/nri.2015.1. PMID:26688349
-
(2016)
Nat Rev Immunol
, vol.16
, pp. 90-101
-
-
Rosenblum, M.D.1
Way, S.S.2
Abbas, A.K.3
-
241
-
-
84997831536
-
Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab
-
26500773,. PMID
-
Ramakrishna V, Sundarapandiyan K, Zhao B, Bylesjo M, Marsh HC, Keler T. Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab. J Immunother Cancer. 2015;3:37. doi:10.1186/s40425-015-0080-2. PMID:26500773
-
(2015)
J Immunother Cancer
, vol.3
, pp. 37
-
-
Ramakrishna, V.1
Sundarapandiyan, K.2
Zhao, B.3
Bylesjo, M.4
Marsh, H.C.5
Keler, T.6
-
242
-
-
85017393100
-
iRECIST: A clarification of tumour response assessment in the immunotherapy era
-
28385325,. PMID
-
Ferte C, Marabelle A. iRECIST: A clarification of tumour response assessment in the immunotherapy era. Eur J Cancer. 2017;77:165-7. doi:10.1016/j.ejca.2017.02.015. PMID:28385325
-
(2017)
Eur J Cancer
, vol.77
, pp. 165-167
-
-
Ferte, C.1
Marabelle, A.2
-
244
-
-
85014322386
-
iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics
-
28271869, et al.,. PMID
-
Seymour L, Bogaerts J, Perrone A, Ford R, Schwartz LH, Mandrekar S, Lin NU, Litiere S, Dancey J, Chen A, et al. iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics. Lancet Oncol. 2017;18:e143-e52. doi:10.1016/S1470-2045(17)30074-8. PMID:28271869
-
(2017)
Lancet Oncol
, vol.18
, pp. 143-152
-
-
Seymour, L.1
Bogaerts, J.2
Perrone, A.3
Ford, R.4
Schwartz, L.H.5
Mandrekar, S.6
Lin, N.U.7
Litiere, S.8
Dancey, J.9
Chen, A.10
-
245
-
-
84933277745
-
Type I interferons in anticancer immunity
-
26027717,. PMID
-
Zitvogel L, Galluzzi L, Kepp O, Smyth MJ, Kroemer G. Type I interferons in anticancer immunity. Nat Rev Immunol. 2015;15:405-14. doi:10.1038/nri3845. PMID:26027717
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 405-414
-
-
Zitvogel, L.1
Galluzzi, L.2
Kepp, O.3
Smyth, M.J.4
Kroemer, G.5
-
246
-
-
85019727443
-
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
-
28598415,. PMID
-
Vanpouille-Box C, Alard A, Aryankalayil MJ, Sarfraz Y, Diamond JM, Schneider RJ, Inghirami G, Coleman CN, Formenti SC, Demaria S. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat Commun. 2017;8:15618. doi:10.1038/ncomms15618. PMID:28598415
-
(2017)
Nat Commun
, vol.8
, pp. 15618
-
-
Vanpouille-Box, C.1
Alard, A.2
Aryankalayil, M.J.3
Sarfraz, Y.4
Diamond, J.M.5
Schneider, R.J.6
Inghirami, G.7
Coleman, C.N.8
Formenti, S.C.9
Demaria, S.10
-
247
-
-
84938506465
-
Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer
-
26300886, et al.,. PMID
-
Fucikova J, Moserova I, Urbanova L, Bezu L, Kepp O, Cremer I, Salek C, Strnad P, Kroemer G, Galluzzi L, et al. Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer. Front Immunol. 2015;6:402. doi:10.3389/fimmu.2015.00402. PMID:26300886
-
(2015)
Front Immunol
, vol.6
, pp. 402
-
-
Fucikova, J.1
Moserova, I.2
Urbanova, L.3
Bezu, L.4
Kepp, O.5
Cremer, I.6
Salek, C.7
Strnad, P.8
Kroemer, G.9
Galluzzi, L.10
-
248
-
-
34447136111
-
A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib
-
17616683, et al.,. PMID
-
de La Motte Rouge T, Galluzzi L, Olaussen KA, Zermati Y, Tasdemir E, Robert T, Ripoche H, Lazar V, Dessen P, Harper F, et al. A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib. Cancer Res. 2007;67:6253-62. doi:10.1158/0008-5472.CAN-07-0538. PMID:17616683
-
(2007)
Cancer Res
, vol.67
, pp. 6253-6262
-
-
de La Motte Rouge, T.1
Galluzzi, L.2
Olaussen, K.A.3
Zermati, Y.4
Tasdemir, E.5
Robert, T.6
Ripoche, H.7
Lazar, V.8
Dessen, P.9
Harper, F.10
-
249
-
-
84976522840
-
Epithelial NF-kappaB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment
-
27471643, et al.,. PMID
-
Saxon JA, Sherrill TP, Polosukhin VV, Sai J, Zaynagetdinov R, McLoed AG, Gulleman PM, Barham W, Cheng DS, Hunt RP, et al. Epithelial NF-kappaB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment. Oncoimmunology. 2016;5:e1168549. doi:10.1080/2162402X.2016.1168549. PMID:27471643
-
(2016)
Oncoimmunology
, vol.5
, pp. 1168549
-
-
Saxon, J.A.1
Sherrill, T.P.2
Polosukhin, V.V.3
Sai, J.4
Zaynagetdinov, R.5
McLoed, A.G.6
Gulleman, P.M.7
Barham, W.8
Cheng, D.S.9
Hunt, R.P.10
-
250
-
-
84977071041
-
Cytokine responsiveness of CD8(+) T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients
-
24883189,. PMID
-
Everson RG, Jin RM, Wang X, Safaee M, Scharnweber R, Lisiero DN, Soto H, Liau LM, Prins RM. Cytokine responsiveness of CD8(+) T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients. J Immunother Cancer. 2014;2:10. doi:10.1186/2051-1426-2-10. PMID:24883189
-
(2014)
J Immunother Cancer
, vol.2
, pp. 10
-
-
Everson, R.G.1
Jin, R.M.2
Wang, X.3
Safaee, M.4
Scharnweber, R.5
Lisiero, D.N.6
Soto, H.7
Liau, L.M.8
Prins, R.M.9
-
251
-
-
85018934527
-
Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma
-
28266140, et al.,. PMID
-
Yamazaki N, Kiyohara Y, Uhara H, Iizuka H, Uehara J, Otsuka F, Fujisawa Y, Takenouchi T, Isei T, Iwatsuki K, et al. Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma. Cancer Sci. 2017;108:1022-31. doi:10.1111/cas.13226. PMID:28266140
-
(2017)
Cancer Sci
, vol.108
, pp. 1022-1031
-
-
Yamazaki, N.1
Kiyohara, Y.2
Uhara, H.3
Iizuka, H.4
Uehara, J.5
Otsuka, F.6
Fujisawa, Y.7
Takenouchi, T.8
Isei, T.9
Iwatsuki, K.10
-
252
-
-
84906559162
-
Phenotypic models of T cell activation
-
25145757,. PMID
-
Lever M, Maini PK, van der Merwe PA, Dushek O. Phenotypic models of T cell activation. Nat Rev Immunol. 2014;14:619-29. doi:10.1038/nri3728. PMID:25145757
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 619-629
-
-
Lever, M.1
Maini, P.K.2
van der Merwe, P.A.3
Dushek, O.4
-
253
-
-
84978634373
-
T cell receptor signalling in the control of regulatory T cell differentiation and function
-
27026074,. PMID
-
Li MO, Rudensky AY. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol. 2016;16:220-33. doi:10.1038/nri.2016.26. PMID:27026074
-
(2016)
Nat Rev Immunol
, vol.16
, pp. 220-233
-
-
Li, M.O.1
Rudensky, A.Y.2
-
254
-
-
84903277871
-
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
-
24962260,. PMID
-
Pollizzi KN, Powell JD. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat Rev Immunol. 2014;14:435-46. doi:10.1038/nri3701. PMID:24962260
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 435-446
-
-
Pollizzi, K.N.1
Powell, J.D.2
-
255
-
-
84989245025
-
Cancer: Tumour-specific ablation of Treg cells induces anticancer response
-
Flemming A. Cancer: Tumour-specific ablation of Treg cells induces anticancer response. Nat Rev Drug Discov. 2016;15:676-7. doi:10.1038/nrd.2016.198.
-
(2016)
Nat Rev Drug Discov
, vol.15
, pp. 676-677
-
-
Flemming, A.1
-
256
-
-
84858800620
-
The immune contexture in human tumours: impact on clinical outcome
-
22419253,. PMID
-
Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012;12:298-306. doi:10.1038/nrc3245. PMID:22419253
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 298-306
-
-
Fridman, W.H.1
Pages, F.2
Sautes-Fridman, C.3
Galon, J.4
-
258
-
-
85030168908
-
The regulation of immune tolerance by FOXP3
-
28757603,;in press. PMID
-
Lu L, Barbi J, Pan F. The regulation of immune tolerance by FOXP3. Nat Rev Immunol. 2017;in press. doi:10.1038/nri.2017.75. PMID: 28757603
-
(2017)
Nat Rev Immunol
-
-
Lu, L.1
Barbi, J.2
Pan, F.3
-
259
-
-
84880894822
-
Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance
-
23104434,. PMID
-
Tanchot C, Terme M, Pere H, Tran T, Benhamouda N, Strioga M, Banissi C, Galluzzi L, Kroemer G, Tartour E. Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance. Cancer Microenviron. 2013;6:147-57. doi:10.1007/s12307-012-0122-y. PMID:23104434
-
(2013)
Cancer Microenviron
, vol.6
, pp. 147-157
-
-
Tanchot, C.1
Terme, M.2
Pere, H.3
Tran, T.4
Benhamouda, N.5
Strioga, M.6
Banissi, C.7
Galluzzi, L.8
Kroemer, G.9
Tartour, E.10
-
260
-
-
67650657178
-
Dacetuzumab, a humanized mAb against CD40 for the treatment of hematological malignancies
-
19513947,. PMID
-
Khubchandani S, Czuczman MS, Hernandez-Ilizaliturri FJ. Dacetuzumab, a humanized mAb against CD40 for the treatment of hematological malignancies. Curr Opin Investig Drugs. 2009;10:579-87. PMID:19513947
-
(2009)
Curr Opin Investig Drugs
, vol.10
, pp. 579-587
-
-
Khubchandani, S.1
Czuczman, M.S.2
Hernandez-Ilizaliturri, F.J.3
-
261
-
-
70349334508
-
Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
-
19636010,. PMID
-
Advani R, Forero-Torres A, Furman RR, Rosenblatt JD, Younes A, Ren H, Harrop K, Whiting N, Drachman JG. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol. 2009;27:4371-7. doi:10.1200/JCO.2008.21.3017. PMID:19636010
-
(2009)
J Clin Oncol
, vol.27
, pp. 4371-4377
-
-
Advani, R.1
Forero-Torres, A.2
Furman, R.R.3
Rosenblatt, J.D.4
Younes, A.5
Ren, H.6
Harrop, K.7
Whiting, N.8
Drachman, J.G.9
-
262
-
-
76349120845
-
A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
-
20038235,. PMID
-
Furman RR, Forero-Torres A, Shustov A, Drachman JG. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2010;51:228-35. doi:10.3109/10428190903440946. PMID:20038235
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 228-235
-
-
Furman, R.R.1
Forero-Torres, A.2
Shustov, A.3
Drachman, J.G.4
-
263
-
-
77952315198
-
A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma
-
20133895,. PMID
-
Hussein M, Berenson JR, Niesvizky R, Munshi N, Matous J, Sobecks R, Harrop K, Drachman JG, Whiting N. A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma. Haematologica. 2010;95:845-8. doi:10.3324/haematol.2009.008003. PMID:20133895
-
(2010)
Haematologica
, vol.95
, pp. 845-848
-
-
Hussein, M.1
Berenson, J.R.2
Niesvizky, R.3
Munshi, N.4
Matous, J.5
Sobecks, R.6
Harrop, K.7
Drachman, J.G.8
Whiting, N.9
-
264
-
-
84872047730
-
Pilot study of dacetuzumab in combination with rituximab and gemcitabine for relapsed or refractory diffuse large B-cell lymphoma
-
22775314,. PMID
-
Forero-Torres A, Bartlett N, Beaven A, Myint H, Nasta S, Northfelt DW, Whiting NC, Drachman JG, Lobuglio AF, Moskowitz CH. Pilot study of dacetuzumab in combination with rituximab and gemcitabine for relapsed or refractory diffuse large B-cell lymphoma. Leuk Lymphoma. 2013;54:277-83. doi:10.3109/10428194.2012.710328. PMID:22775314
-
(2013)
Leuk Lymphoma
, vol.54
, pp. 277-283
-
-
Forero-Torres, A.1
Bartlett, N.2
Beaven, A.3
Myint, H.4
Nasta, S.5
Northfelt, D.W.6
Whiting, N.C.7
Drachman, J.G.8
Lobuglio, A.F.9
Moskowitz, C.H.10
-
265
-
-
84959378533
-
Immunotherapy for cancer in the central nervous system: Current and future directions
-
27057463,. PMID
-
Binder DC, Davis AA, Wainwright DA. Immunotherapy for cancer in the central nervous system: Current and future directions. Oncoimmunology. 2016;5:e1082027. doi:10.1080/2162402X.2015.1082027. PMID:27057463
-
(2016)
Oncoimmunology
, vol.5
, pp. 1082027
-
-
Binder, D.C.1
Davis, A.A.2
Wainwright, D.A.3
-
266
-
-
84978484590
-
Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop
-
27622041, et al.,. PMID
-
Houot R, Gaulard P, Schreiber R, Mellman I, Lambotte O, Coulie PG, Fest T, Korman A, Levy R, Shipp M, et al. Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop. Oncoimmunology. 2016;5:e1186323. doi:10.1080/2162402X.2016.1186323. PMID:27622041
-
(2016)
Oncoimmunology
, vol.5
, pp. 1186323
-
-
Houot, R.1
Gaulard, P.2
Schreiber, R.3
Mellman, I.4
Lambotte, O.5
Coulie, P.G.6
Fest, T.7
Korman, A.8
Levy, R.9
Shipp, M.10
-
267
-
-
85031736840
-
Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer
-
28761757,. PMID
-
Granier C, De Guillebon E, Blanc C, Roussel H, Badoual C, Colin E, Saldmann A, Gey A, Oudard S, Tartour E. Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer. ESMO Open. 2017;2:e000213. doi:10.1136/esmoopen-2017-000213. PMID:28761757
-
(2017)
ESMO Open
, vol.2
, pp. 213
-
-
Granier, C.1
De Guillebon, E.2
Blanc, C.3
Roussel, H.4
Badoual, C.5
Colin, E.6
Saldmann, A.7
Gey, A.8
Oudard, S.9
Tartour, E.10
-
268
-
-
85026522198
-
PD-1/PD-L1 checkpoint blockades in non-small cell lung cancer: New development and challenges
-
28688973,. PMID
-
Meng X, Liu Y, Zhang J, Teng F, Xing L, Yu J. PD-1/PD-L1 checkpoint blockades in non-small cell lung cancer: New development and challenges. Cancer Lett. 2017;405:29-37. doi:10.1016/j.canlet.2017.06.033. PMID:28688973
-
(2017)
Cancer Lett
, vol.405
, pp. 29-37
-
-
Meng, X.1
Liu, Y.2
Zhang, J.3
Teng, F.4
Xing, L.5
Yu, J.6
-
269
-
-
84994120928
-
PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas
-
27805626,. PMID
-
Goodman A, Patel SP, Kurzrock R. PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat Rev Clin Oncol. 2017;14:203-20. doi:10.1038/nrclinonc.2016.168. PMID:27805626
-
(2017)
Nat Rev Clin Oncol
, vol.14
, pp. 203-220
-
-
Goodman, A.1
Patel, S.P.2
Kurzrock, R.3
-
270
-
-
84938350452
-
Combination cancer immunotherapy and new immunomodulatory targets
-
26228759,. PMID
-
Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov. 2015;14:561-84. doi:10.1038/nrd4591. PMID:26228759
-
(2015)
Nat Rev Drug Discov
, vol.14
, pp. 561-584
-
-
Mahoney, K.M.1
Rennert, P.D.2
Freeman, G.J.3
-
271
-
-
85015975300
-
Prospects for combining targeted and conventional cancer therapy with immunotherapy
-
28338065, et al.,. PMID
-
Gotwals P, Cameron S, Cipolletta D, Cremasco V, Crystal A, Hewes B, Mueller B, Quaratino S, Sabatos-Peyton C, Petruzzelli L, et al. Prospects for combining targeted and conventional cancer therapy with immunotherapy. Nat Rev Cancer. 2017;17:286-301. doi:10.1038/nrc.2017.17. PMID:28338065
-
(2017)
Nat Rev Cancer
, vol.17
, pp. 286-301
-
-
Gotwals, P.1
Cameron, S.2
Cipolletta, D.3
Cremasco, V.4
Crystal, A.5
Hewes, B.6
Mueller, B.7
Quaratino, S.8
Sabatos-Peyton, C.9
Petruzzelli, L.10
-
272
-
-
84974803082
-
Radiotherapy: Changing the Game in Immunotherapy
-
27774519,. PMID
-
Demaria S, Coleman CN, Formenti SC. Radiotherapy: Changing the Game in Immunotherapy. Trends Cancer. 2016;2:286-94. doi:10.1016/j.trecan.2016.05.002. PMID:27774519
-
(2016)
Trends Cancer
, vol.2
, pp. 286-294
-
-
Demaria, S.1
Coleman, C.N.2
Formenti, S.C.3
-
273
-
-
85040734981
-
Towards precision radiotherapy for use with immune checkpoint blockers
-
Vanpouille-Box C, Formenti SC, Demaria S. Towards precision radiotherapy for use with immune checkpoint blockers. Clin Cancer Res. 2017. doi:10.1158/1078-0432.CCR-16-0037.
-
(2017)
Clin Cancer Res
-
-
Vanpouille-Box, C.1
Formenti, S.C.2
Demaria, S.3
-
274
-
-
84995370898
-
Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
-
27845767,. PMID
-
Galluzzi L, Bravo-San Pedro JM, Demaria S, Formenti SC, Kroemer G. Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol. 2017;14:247-58. doi:10.1038/nrclinonc.2016.183. PMID:27845767
-
(2017)
Nat Rev Clin Oncol
, vol.14
, pp. 247-258
-
-
Galluzzi, L.1
Bravo-San Pedro, J.M.2
Demaria, S.3
Formenti, S.C.4
Kroemer, G.5
-
275
-
-
85007280340
-
Making the Most of Cancer Surgery with Neoadjuvant Immunotherapy
-
27920139,. PMID
-
Melero I, Berraondo P, Rodriguez-Ruiz ME, Perez-Gracia JL. Making the Most of Cancer Surgery with Neoadjuvant Immunotherapy. Cancer Discov. 2016;6:1312-4. doi:10.1158/2159-8290.CD-16-1109. PMID:27920139
-
(2016)
Cancer Discov
, vol.6
, pp. 1312-1314
-
-
Melero, I.1
Berraondo, P.2
Rodriguez-Ruiz, M.E.3
Perez-Gracia, J.L.4
-
276
-
-
84891001835
-
Diffuse large B-cell lymphoma-treatment approaches in the molecular era
-
24217204,. PMID
-
Roschewski M, Staudt LM, Wilson WH. Diffuse large B-cell lymphoma-treatment approaches in the molecular era. Nat Rev Clin Oncol. 2014;11:12-23. doi:10.1038/nrclinonc.2013.197. PMID:24217204
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 12-23
-
-
Roschewski, M.1
Staudt, L.M.2
Wilson, W.H.3
-
277
-
-
84975882004
-
Combating rituximab resistance by inducing ceramide/lysosome-involved cell death through initiation of CD20-TNFR1 co-localization
-
27467962, et al.,. PMID
-
Zhang F, Yang J, Li H, Liu M, Zhang J, Zhao L, Wang L, LingHu R, Feng F, Gao X, et al. Combating rituximab resistance by inducing ceramide/lysosome-involved cell death through initiation of CD20-TNFR1 co-localization. Oncoimmunology. 2016;5:e1143995. doi:10.1080/2162402X.2016.1143995. PMID:27467962
-
(2016)
Oncoimmunology
, vol.5
, pp. 1143995
-
-
Zhang, F.1
Yang, J.2
Li, H.3
Liu, M.4
Zhang, J.5
Zhao, L.6
Wang, L.7
LingHu, R.8
Feng, F.9
Gao, X.10
-
278
-
-
85025151450
-
Targeted therapies for renal cell carcinoma
-
28691713,. PMID
-
Posadas EM, Limvorasak S, Figlin RA. Targeted therapies for renal cell carcinoma. Nat Rev Nephrol. 2017;13:496-511. doi:10.1038/nrneph.2017.82. PMID:28691713
-
(2017)
Nat Rev Nephrol
, vol.13
, pp. 496-511
-
-
Posadas, E.M.1
Limvorasak, S.2
Figlin, R.A.3
-
279
-
-
84940705588
-
A rationally designed combined treatment with an alphavirus-based cancer vaccine, sunitinib and low-dose tumor irradiation completely blocks tumor development
-
26451295,. PMID
-
Draghiciu O, Boerma A, Hoogeboom BN, Nijman HW, Daemen T. A rationally designed combined treatment with an alphavirus-based cancer vaccine, sunitinib and low-dose tumor irradiation completely blocks tumor development. Oncoimmunology. 2015;4:e1029699. doi:10.1080/2162402X.2015.1029699. PMID:26451295
-
(2015)
Oncoimmunology
, vol.4
, pp. 1029699
-
-
Draghiciu, O.1
Boerma, A.2
Hoogeboom, B.N.3
Nijman, H.W.4
Daemen, T.5
-
280
-
-
85035352368
-
Improving outcomes in high-risk, nonmetastatic renal cancer: new data and ongoing trials
-
28762388,;in press. PMID
-
Blick C, Ritchie AWS, Eisen T, Stewart GD. Improving outcomes in high-risk, nonmetastatic renal cancer: new data and ongoing trials. Nat Rev Urol. 2017;in press. doi:10.1038/nrurol.2017.123. PMID:28762388
-
(2017)
Nat Rev Urol
-
-
Blick, C.1
Ritchie, A.W.S.2
Eisen, T.3
Stewart, G.D.4
-
281
-
-
84977125861
-
Combine and conquer: challenges for targeted therapy combinations in early phase trials
-
27377132,. PMID
-
Lopez JS, Banerji U. Combine and conquer: challenges for targeted therapy combinations in early phase trials. Nat Rev Clin Oncol. 2017;14:57-66. doi:10.1038/nrclinonc.2016.96. PMID:27377132
-
(2017)
Nat Rev Clin Oncol
, vol.14
, pp. 57-66
-
-
Lopez, J.S.1
Banerji, U.2
-
282
-
-
84887045362
-
Metabolic targets for cancer therapy
-
24113830,. PMID
-
Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nat Rev Drug Discov. 2013;12:829-46. doi:10.1038/nrd4145. PMID:24113830
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 829-846
-
-
Galluzzi, L.1
Kepp, O.2
Vander Heiden, M.G.3
Kroemer, G.4
-
283
-
-
84954328791
-
Trial Watch: Peptide-based anticancer vaccines
-
26137405, et al.,. PMID
-
Pol J, Bloy N, Buque A, Eggermont A, Cremer I, Sautes-Fridman C, Galon J, Tartour E, Zitvogel L, Kroemer G, et al. Trial Watch: Peptide-based anticancer vaccines. Oncoimmunology. 2015;4:e974411. doi:10.4161/2162402X.2014.974411. PMID:26137405
-
(2015)
Oncoimmunology
, vol.4
, pp. 974411
-
-
Pol, J.1
Bloy, N.2
Buque, A.3
Eggermont, A.4
Cremer, I.5
Sautes-Fridman, C.6
Galon, J.7
Tartour, E.8
Zitvogel, L.9
Kroemer, G.10
-
284
-
-
84994181514
-
Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor
-
27999750,. PMID
-
Le Noci V, Sommariva M, Tortoreto M, Zaffaroni N, Campiglio M, Tagliabue E, Balsari A, Sfondrini L. Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor. Oncoimmunology. 2016;5:e1234571. doi:10.1080/2162402X.2016.1234571. PMID:27999750
-
(2016)
Oncoimmunology
, vol.5
, pp. 1234571
-
-
Le Noci, V.1
Sommariva, M.2
Tortoreto, M.3
Zaffaroni, N.4
Campiglio, M.5
Tagliabue, E.6
Balsari, A.7
Sfondrini, L.8
-
285
-
-
84961671432
-
Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy
-
27141345, et al.,. PMID
-
Iribarren K, Bloy N, Buque A, Cremer I, Eggermont A, Fridman WH, Fucikova J, Galon J, Spisek R, Zitvogel L, et al. Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy. Oncoimmunology. 2016;5:e1088631. doi:10.1080/2162402X.2015.1088631. PMID:27141345
-
(2016)
Oncoimmunology
, vol.5
, pp. 1088631
-
-
Iribarren, K.1
Bloy, N.2
Buque, A.3
Cremer, I.4
Eggermont, A.5
Fridman, W.H.6
Fucikova, J.7
Galon, J.8
Spisek, R.9
Zitvogel, L.10
-
286
-
-
84940451580
-
Translating nucleic acid-sensing pathways into therapies
-
26292638,. PMID
-
Junt T, Barchet W. Translating nucleic acid-sensing pathways into therapies. Nat Rev Immunol. 2015;15:529-44. doi:10.1038/nri3875. PMID:26292638
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 529-544
-
-
Junt, T.1
Barchet, W.2
-
287
-
-
77950542752
-
Targeting Toll-like receptors: emerging therapeutics?
-
20380038,. PMID
-
Hennessy EJ, Parker AE, O'Neill LA. Targeting Toll-like receptors: emerging therapeutics? Nat Rev Drug Discov. 2010;9:293-307. doi:10.1038/nrd3203. PMID:20380038
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 293-307
-
-
Hennessy, E.J.1
Parker, A.E.2
O'Neill, L.A.3
-
288
-
-
85014927523
-
Renal cell carcinoma
-
28276433,. PMID
-
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V. Renal cell carcinoma. Nat Rev Dis Primers. 2017;3:17009. doi:10.1038/nrdp.2017.9. PMID:28276433
-
(2017)
Nat Rev Dis Primers
, vol.3
, pp. 17009
-
-
Hsieh, J.J.1
Purdue, M.P.2
Signoretti, S.3
Swanton, C.4
Albiges, L.5
Schmidinger, M.6
Heng, D.Y.7
Larkin, J.8
Ficarra, V.9
-
289
-
-
84978522783
-
The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy
-
27622042,. PMID
-
Roselli M, Formica V, Cereda V, Jochems C, Richards J, Grenga I, Orlandi A, Ferroni P, Guadagni F, Schlom J. The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy. Oncoimmunology. 2016;5:e1188243. doi:10.1080/2162402X.2016.1188243. PMID:27622042
-
(2016)
Oncoimmunology
, vol.5
, pp. 1188243
-
-
Roselli, M.1
Formica, V.2
Cereda, V.3
Jochems, C.4
Richards, J.5
Grenga, I.6
Orlandi, A.7
Ferroni, P.8
Guadagni, F.9
Schlom, J.10
-
290
-
-
84982131766
-
Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling
-
27529514, et al.,. PMID
-
Baker LC, Boult JK, Thomas M, Koehler A, Nayak T, Tessier J, Ooi CH, Birzele F, Belousov A, Zajac M, et al. Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling. Br J Cancer. 2016;115:691-702. doi:10.1038/bjc.2016.236. PMID:27529514
-
(2016)
Br J Cancer
, vol.115
, pp. 691-702
-
-
Baker, L.C.1
Boult, J.K.2
Thomas, M.3
Koehler, A.4
Nayak, T.5
Tessier, J.6
Ooi, C.H.7
Birzele, F.8
Belousov, A.9
Zajac, M.10
-
291
-
-
84979224082
-
The use of CrossMAb technology for the generation of bi- and multispecific antibodies
-
27285945,. PMID
-
Klein C, Schaefer W, Regula JT. The use of CrossMAb technology for the generation of bi- and multispecific antibodies. MAbs. 2016;8:1010-20. doi:10.1080/19420862.2016.1197457. PMID:27285945
-
(2016)
MAbs
, vol.8
, pp. 1010-1020
-
-
Klein, C.1
Schaefer, W.2
Regula, J.T.3
-
292
-
-
84961393064
-
Novel anti-angiogenic therapeutic strategies in colorectal cancer
-
26938715,. PMID
-
Tampellini M, Sonetto C, Scagliotti GV. Novel anti-angiogenic therapeutic strategies in colorectal cancer. Expert Opin Investig Drugs. 2016;25:507-20. doi:10.1517/13543784.2016.1161754. PMID:26938715
-
(2016)
Expert Opin Investig Drugs
, vol.25
, pp. 507-520
-
-
Tampellini, M.1
Sonetto, C.2
Scagliotti, G.V.3
-
293
-
-
84961589082
-
Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model
-
27141347,. PMID
-
Chang DK, Peterson E, Sun J, Goudie C, Drapkin RI, Liu JF, Matulonis U, Zhu Q, Marasco WA. Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model. Oncoimmunology. 2016;5:e1090075. doi:10.1080/2162402X.2015.1090075. PMID:27141347
-
(2016)
Oncoimmunology
, vol.5
, pp. 1090075
-
-
Chang, D.K.1
Peterson, E.2
Sun, J.3
Goudie, C.4
Drapkin, R.I.5
Liu, J.F.6
Matulonis, U.7
Zhu, Q.8
Marasco, W.A.9
-
294
-
-
84925358053
-
Mogamulizumab: 2 birds, 1 stone
-
25792728,. PMID
-
Wilcox RA. Mogamulizumab: 2 birds, 1 stone. Blood. 2015;125:1847-8. doi:10.1182/blood-2015-02-625251. PMID:25792728
-
(2015)
Blood
, vol.125
, pp. 1847-1848
-
-
Wilcox, R.A.1
-
295
-
-
84938090300
-
CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study
-
26179200, et al.,. PMID
-
Cassier PA, Italiano A, Gomez-Roca CA, Le Tourneau C, Toulmonde M, Cannarile MA, Ries C, Brillouet A, Muller C, Jegg AM, et al. CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study. Lancet Oncol. 2015;16:949-56. doi:10.1016/S1470-2045(15)00132-1. PMID:26179200
-
(2015)
Lancet Oncol
, vol.16
, pp. 949-956
-
-
Cassier, P.A.1
Italiano, A.2
Gomez-Roca, C.A.3
Le Tourneau, C.4
Toulmonde, M.5
Cannarile, M.A.6
Ries, C.7
Brillouet, A.8
Muller, C.9
Jegg, A.M.10
-
296
-
-
85024385914
-
Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy
-
Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, Ruttinger D. Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. J Immunother Cancer. 2017;5:53. doi:10.1186/s40425-017-0257-y.
-
(2017)
J Immunother Cancer
, vol.5
, pp. 53
-
-
Cannarile, M.A.1
Weisser, M.2
Jacob, W.3
Jegg, A.M.4
Ries, C.H.5
Ruttinger, D.6
-
297
-
-
84944463983
-
Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors
-
26155427,. PMID
-
Casbon AJ, Lohela M, Werb Z. Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors. Oncoimmunology. 2015;4:e1008871. doi:10.1080/2162402X.2015.1008871. PMID:26155427
-
(2015)
Oncoimmunology
, vol.4
, pp. 1008871
-
-
Casbon, A.J.1
Lohela, M.2
Werb, Z.3
-
298
-
-
84861735070
-
Treatment selection in metastatic renal cell carcinoma: expert consensus
-
22473096,. PMID
-
Escudier B, Szczylik C, Porta C, Gore M. Treatment selection in metastatic renal cell carcinoma: expert consensus. Nat Rev Clin Oncol. 2012;9:327-37. doi:10.1038/nrclinonc.2012.59. PMID:22473096
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 327-337
-
-
Escudier, B.1
Szczylik, C.2
Porta, C.3
Gore, M.4
-
299
-
-
84886405297
-
Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity
-
23965900,. PMID
-
Marabelle A, Kohrt H, Levy R. Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity. Clin Cancer Res. 2013;19:5261-3. doi:10.1158/1078-0432.CCR-13-1923. PMID:23965900
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5261-5263
-
-
Marabelle, A.1
Kohrt, H.2
Levy, R.3
-
300
-
-
84886427186
-
Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects
-
23788581,. PMID
-
Fransen MF, van der Sluis TC, Ossendorp F, Arens R, Melief CJ. Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects. Clin Cancer Res. 2013;19:5381-9. doi:10.1158/1078-0432.CCR-12-0781. PMID:23788581
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5381-5389
-
-
Fransen, M.F.1
van der Sluis, T.C.2
Ossendorp, F.3
Arens, R.4
Melief, C.J.5
-
301
-
-
84899112560
-
Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy
-
24701370,. PMID
-
Aranda F, Vacchelli E, Eggermont A, Galon J, Fridman WH, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy. Oncoimmunology. 2014;3:e27297. doi:10.4161/onci.27297. PMID:24701370
-
(2014)
Oncoimmunology
, vol.3
, pp. 27297
-
-
Aranda, F.1
Vacchelli, E.2
Eggermont, A.3
Galon, J.4
Fridman, W.H.5
Zitvogel, L.6
Kroemer, G.7
Galluzzi, L.8
-
302
-
-
84858797619
-
Trial Watch: Monoclonal antibodies in cancer therapy
-
22720209,. PMID
-
Galluzzi L, Vacchelli E, Fridman WH, Galon J, Sautes-Fridman C, Tartour E, Zucman-Rossi J, Zitvogel L, Kroemer G. Trial Watch: Monoclonal antibodies in cancer therapy. Oncoimmunology. 2012;1:28-37. doi:10.4161/onci.1.1.17938. PMID:22720209
-
(2012)
Oncoimmunology
, vol.1
, pp. 28-37
-
-
Galluzzi, L.1
Vacchelli, E.2
Fridman, W.H.3
Galon, J.4
Sautes-Fridman, C.5
Tartour, E.6
Zucman-Rossi, J.7
Zitvogel, L.8
Kroemer, G.9
-
303
-
-
84994144900
-
Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets
-
27811929,. PMID
-
Shi Y, Du L, Lin L, Wang Y. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov. 2017;16:35-52. doi:10.1038/nrd.2016.193. PMID:27811929
-
(2017)
Nat Rev Drug Discov
, vol.16
, pp. 35-52
-
-
Shi, Y.1
Du, L.2
Lin, L.3
Wang, Y.4
-
304
-
-
85010901048
-
Tumour-associated macrophages as treatment targets in oncology
-
28117416,. PMID
-
Mantovani A, Marchesi F, Malesci A, Laghi L, Allavena P. Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. 2017;14:399-416. doi:10.1038/nrclinonc.2016.217. PMID:28117416
-
(2017)
Nat Rev Clin Oncol
, vol.14
, pp. 399-416
-
-
Mantovani, A.1
Marchesi, F.2
Malesci, A.3
Laghi, L.4
Allavena, P.5
-
305
-
-
84976272206
-
The role of myeloid cells in cancer therapies
-
27339708,. PMID
-
Engblom C, Pfirschke C, Pittet MJ. The role of myeloid cells in cancer therapies. Nat Rev Cancer. 2016;16:447-62. doi:10.1038/nrc.2016.54. PMID:27339708
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 447-462
-
-
Engblom, C.1
Pfirschke, C.2
Pittet, M.J.3
-
306
-
-
85009820249
-
Radiotherapy and immunotherapy: A beneficial liaison?
-
28094262,. PMID
-
Weichselbaum RR, Liang H, Deng L, Fu YX. Radiotherapy and immunotherapy: A beneficial liaison? Nat Rev Clin Oncol. 2017;14:365-79. doi:10.1038/nrclinonc.2016.211. PMID:28094262
-
(2017)
Nat Rev Clin Oncol
, vol.14
, pp. 365-379
-
-
Weichselbaum, R.R.1
Liang, H.2
Deng, L.3
Fu, Y.X.4
-
307
-
-
84959133719
-
Combination cancer immunotherapies tailored to the tumour microenvironment
-
26598942,. PMID
-
Smyth MJ, Ngiow SF, Ribas A, Teng MW. Combination cancer immunotherapies tailored to the tumour microenvironment. Nat Rev Clin Oncol. 2016;13:143-58. doi:10.1038/nrclinonc.2015.209. PMID:26598942
-
(2016)
Nat Rev Clin Oncol
, vol.13
, pp. 143-158
-
-
Smyth, M.J.1
Ngiow, S.F.2
Ribas, A.3
Teng, M.W.4
-
308
-
-
84969988539
-
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy
-
27118494,. PMID
-
Khalil DN, Smith EL, Brentjens RJ, Wolchok JD. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat Rev Clin Oncol. 2016;13:394. doi:10.1038/nrclinonc.2016.65. PMID:27118494
-
(2016)
Nat Rev Clin Oncol
, vol.13
, pp. 394
-
-
Khalil, D.N.1
Smith, E.L.2
Brentjens, R.J.3
Wolchok, J.D.4
|