메뉴 건너뛰기




Volumn 6, Issue 12, 2017, Pages

Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications

Author keywords

CD137; CD40; GITR; ICOS; OX40; PD 1

Indexed keywords

ATEZOLIZUMAB; CD134 ANTIGEN; CD137 ANTIGEN; CD27 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CETUXIMAB; DACETUZUMAB; EMACTUZUMAB; FC RECEPTOR; IPILIMUMAB; MONOCLONAL ANTIBODY; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; RITUXIMAB; TICILIMUMAB; TUMOR NECROSIS FACTOR RECEPTOR; UTOMILUMAB; VANUCIZUMAB; VARLILUMAB; VASCULOTROPIN;

EID: 85030158829     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2017.1371896     Document Type: Review
Times cited : (33)

References (308)
  • 1
    • 85016548232 scopus 로고    scopus 로고
    • Elements of cancer immunity and the cancer-immune set point
    • 28102259,. PMID
    • Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017;541:321-30. doi:10.1038/nature21349. PMID:28102259
    • (2017) Nature , vol.541 , pp. 321-330
    • Chen, D.S.1    Mellman, I.2
  • 2
    • 84991619059 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer and infectious disease
    • 27748397,. PMID
    • Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2017;17:97-111. doi:10.1038/nri.2016.107. PMID:27748397
    • (2017) Nat Rev Immunol , vol.17 , pp. 97-111
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 3
    • 84962896209 scopus 로고    scopus 로고
    • Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity
    • 27141402,. PMID
    • Cheng WC, Ho PC. Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity. Oncoimmunology. 2016;5:e1119355. doi:10.1080/2162402X.2015.1119355. PMID:27141402
    • (2016) Oncoimmunology , vol.5 , pp. 1119355
    • Cheng, W.C.1    Ho, P.C.2
  • 4
    • 84956607773 scopus 로고    scopus 로고
    • Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents
    • 26678337,. PMID
    • Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. Cancer Cell. 2015;28:690-714. doi:10.1016/j.ccell.2015.10.012. PMID:26678337
    • (2015) Cancer Cell , vol.28 , pp. 690-714
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 5
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: the cancer-immunity cycle
    • 23890059,. PMID
    • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39:1-10. doi:10.1016/j.immuni.2013.07.012. PMID:23890059
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 6
    • 84960422665 scopus 로고    scopus 로고
    • The Basis of Oncoimmunology
    • 26967289,. PMID
    • Palucka AK, Coussens LM. The Basis of Oncoimmunology. Cell. 2016;164:1233-47. doi:10.1016/j.cell.2016.01.049. PMID:26967289
    • (2016) Cell , vol.164 , pp. 1233-1247
    • Palucka, A.K.1    Coussens, L.M.2
  • 7
    • 84959440329 scopus 로고    scopus 로고
    • Tumor infiltration by Tbet+ effector T cells and CD20+ B cells is associated with survival in gastric cancer patients
    • 27057426, et al.,. PMID
    • Hennequin A, Derangere V, Boidot R, Apetoh L, Vincent J, Orry D, Fraisse J, Causeret S, Martin F, Arnould L, et al. Tumor infiltration by Tbet+ effector T cells and CD20+ B cells is associated with survival in gastric cancer patients. Oncoimmunology. 2016;5:e1054598. doi:10.1080/2162402X.2015.1054598. PMID:27057426
    • (2016) Oncoimmunology , vol.5 , pp. 1054598
    • Hennequin, A.1    Derangere, V.2    Boidot, R.3    Apetoh, L.4    Vincent, J.5    Orry, D.6    Fraisse, J.7    Causeret, S.8    Martin, F.9    Arnould, L.10
  • 8
    • 84954481360 scopus 로고    scopus 로고
    • Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells
    • 25949911, et al.,. PMID
    • Sanchez-Martinez D, Azaceta G, Muntasell A, Aguilo N, Nunez D, Galvez EM, Naval J, Anel A, Palomera L, Vilches C, et al. Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells. Oncoimmunology. 2015;4:e991613. doi:10.4161/2162402X.2014.991613. PMID:25949911
    • (2015) Oncoimmunology , vol.4 , pp. 991613
    • Sanchez-Martinez, D.1    Azaceta, G.2    Muntasell, A.3    Aguilo, N.4    Nunez, D.5    Galvez, E.M.6    Naval, J.7    Anel, A.8    Palomera, L.9    Vilches, C.10
  • 10
    • 84968725145 scopus 로고    scopus 로고
    • Natural Killer Cell-Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future
    • 26903071,. PMID
    • Muntasell A, Lopez-Botet M. Natural Killer Cell-Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future. Clin Cancer Res. 2016;22:1831-3. doi:10.1158/1078-0432.CCR-15-3168. PMID:26903071
    • (2016) Clin Cancer Res , vol.22 , pp. 1831-1833
    • Muntasell, A.1    Lopez-Botet, M.2
  • 11
    • 85029549369 scopus 로고    scopus 로고
    • Control of metastasis by NK cells
    • 28292442,. PMID
    • Lopez-Soto A, Gonzalez S, Smyth MJ, Galluzzi L. Control of metastasis by NK cells. Cancer Cell. 2017;32:135-154. doi:10.1016/j.ccell.2017.06.009. PMID:28292442
    • (2017) Cancer Cell , vol.32 , pp. 135-154
    • Lopez-Soto, A.1    Gonzalez, S.2    Smyth, M.J.3    Galluzzi, L.4
  • 12
    • 85013073556 scopus 로고    scopus 로고
    • Involvement of autophagy in NK cell development and function
    • 28103115,. PMID
    • Lopez-Soto A, Bravo-San Pedro JM, Kroemer G, Galluzzi L, Gonzalez S. Involvement of autophagy in NK cell development and function. Autophagy. 2017;13:633-6. doi:10.1080/15548627.2016.1274486. PMID:28103115
    • (2017) Autophagy , vol.13 , pp. 633-636
    • Lopez-Soto, A.1    Bravo-San Pedro, J.M.2    Kroemer, G.3    Galluzzi, L.4    Gonzalez, S.5
  • 14
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • 26205583,. PMID
    • Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15:486-99. doi:10.1038/nri3862. PMID:26205583
    • (2015) Nat Rev Immunol , vol.15 , pp. 486-499
    • Wherry, E.J.1    Kurachi, M.2
  • 15
    • 84875223135 scopus 로고    scopus 로고
    • Proposed mechanisms of action for prostate cancer vaccines
    • 23399727,. PMID
    • Geary SM, Lemke CD, Lubaroff DM, Salem AK. Proposed mechanisms of action for prostate cancer vaccines. Nat Rev Urol. 2013;10:149-60. doi:10.1038/nrurol.2013.8. PMID:23399727
    • (2013) Nat Rev Urol , vol.10 , pp. 149-160
    • Geary, S.M.1    Lemke, C.D.2    Lubaroff, D.M.3    Salem, A.K.4
  • 16
    • 84929961969 scopus 로고    scopus 로고
    • Perforin and granzymes: function, dysfunction and human pathology
    • 25998963,. PMID
    • Voskoboinik I, Whisstock JC, Trapani JA. Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol. 2015;15:388-400. doi:10.1038/nri3839. PMID:25998963
    • (2015) Nat Rev Immunol , vol.15 , pp. 388-400
    • Voskoboinik, I.1    Whisstock, J.C.2    Trapani, J.A.3
  • 17
    • 84961666207 scopus 로고    scopus 로고
    • PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity
    • 27141339,. PMID
    • Lim TS, Chew V, Sieow JL, Goh S, Yeong JP, Soon AL, Ricciardi-Castagnoli P. PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity. Oncoimmunology. 2016;5:e1085146. doi:10.1080/2162402X.2015.1085146. PMID:27141339
    • (2016) Oncoimmunology , vol.5 , pp. 1085146
    • Lim, T.S.1    Chew, V.2    Sieow, J.L.3    Goh, S.4    Yeong, J.P.5    Soon, A.L.6    Ricciardi-Castagnoli, P.7
  • 18
    • 84941787327 scopus 로고    scopus 로고
    • Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells
    • 26985398,. PMID
    • Baleeiro RB, Rietscher R, Diedrich A, Czaplewska JA, Lehr CM, Scherliess R, Hanefeld A, Gottschaldt M, Walden P. Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells. Oncoimmunology. 2015;4:e1047585. doi:10.1080/2162402X.2015.1047585. PMID:26985398
    • (2015) Oncoimmunology , vol.4 , pp. 1047585
    • Baleeiro, R.B.1    Rietscher, R.2    Diedrich, A.3    Czaplewska, J.A.4    Lehr, C.M.5    Scherliess, R.6    Hanefeld, A.7    Gottschaldt, M.8    Walden, P.9
  • 20
    • 85014911516 scopus 로고    scopus 로고
    • Dying cells actively regulate adaptive immune responses
    • 28287107,. PMID
    • Yatim N, Cullen S, Albert ML. Dying cells actively regulate adaptive immune responses. Nat Rev Immunol. 2017;17:262-75. doi:10.1038/nri.2017.9. PMID:28287107
    • (2017) Nat Rev Immunol , vol.17 , pp. 262-275
    • Yatim, N.1    Cullen, S.2    Albert, M.L.3
  • 21
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • 23470321,. PMID
    • Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013;13:227-42. doi:10.1038/nri3405. PMID:23470321
    • (2013) Nat Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 22
    • 85016137167 scopus 로고    scopus 로고
    • Immunological Mechanisms Underneath the Efficacy of Cancer Therapy
    • 27803050,. PMID
    • Galluzzi L, Zitvogel L, Kroemer G. Immunological Mechanisms Underneath the Efficacy of Cancer Therapy. Cancer Immunol Res. 2016;4:895-902. doi:10.1158/2326-6066.CIR-16-0197. PMID:27803050
    • (2016) Cancer Immunol Res , vol.4 , pp. 895-902
    • Galluzzi, L.1    Zitvogel, L.2    Kroemer, G.3
  • 23
    • 80054875478 scopus 로고    scopus 로고
    • Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease
    • 22017435,. PMID
    • Rickert RC, Jellusova J, Miletic AV. Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease. Immunol Rev. 2011;244:115-33. doi:10.1111/j.1600-065X.2011.01067.x. PMID:22017435
    • (2011) Immunol Rev , vol.244 , pp. 115-133
    • Rickert, R.C.1    Jellusova, J.2    Miletic, A.V.3
  • 24
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • 19319144,. PMID
    • Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol. 2009;9:271-85. doi:10.1038/nri2526. PMID:19319144
    • (2009) Nat Rev Immunol , vol.9 , pp. 271-285
    • Croft, M.1
  • 25
    • 84941758827 scopus 로고    scopus 로고
    • Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
    • 26451310, et al.,. PMID
    • Dai H, Zhang W, Li X, Han Q, Guo Y, Zhang Y, Wang Y, Wang C, Shi F, Zhang Y, et al. Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. Oncoimmunology. 2015;4:e1027469. doi:10.1080/2162402X.2015.1027469. PMID:26451310
    • (2015) Oncoimmunology , vol.4 , pp. 1027469
    • Dai, H.1    Zhang, W.2    Li, X.3    Han, Q.4    Guo, Y.5    Zhang, Y.6    Wang, Y.7    Wang, C.8    Shi, F.9    Zhang, Y.10
  • 26
    • 84893711428 scopus 로고    scopus 로고
    • Tolerance and exhaustion: defining mechanisms of T cell dysfunction
    • 24210163,. PMID
    • Schietinger A, Greenberg PD. Tolerance and exhaustion: defining mechanisms of T cell dysfunction. Trends Immunol. 2014;35:51-60. doi:10.1016/j.it.2013.10.001. PMID:24210163
    • (2014) Trends Immunol , vol.35 , pp. 51-60
    • Schietinger, A.1    Greenberg, P.D.2
  • 27
    • 84877059916 scopus 로고    scopus 로고
    • T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
    • 23298609,. PMID
    • Crespo J, Sun H, Welling TH, Tian Z, Zou W. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment. Curr Opin Immunol. 2013;25:214-21. doi:10.1016/j.coi.2012.12.003. PMID:23298609
    • (2013) Curr Opin Immunol , vol.25 , pp. 214-221
    • Crespo, J.1    Sun, H.2    Welling, T.H.3    Tian, Z.4    Zou, W.5
  • 28
    • 84951310757 scopus 로고    scopus 로고
    • NK cells and cancer: you can teach innate cells new tricks
    • 26694935,. PMID
    • Morvan MG, Lanier LL. NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer. 2016;16:7-19. doi:10.1038/nrc.2015.5. PMID:26694935
    • (2016) Nat Rev Cancer , vol.16 , pp. 7-19
    • Morvan, M.G.1    Lanier, L.L.2
  • 29
    • 84925743331 scopus 로고    scopus 로고
    • Balancing natural killer cell activation through paired receptors
    • 25743219,. PMID
    • Martinet L, Smyth MJ. Balancing natural killer cell activation through paired receptors. Nat Rev Immunol. 2015;15:243-54. doi:10.1038/nri3799. PMID:25743219
    • (2015) Nat Rev Immunol , vol.15 , pp. 243-254
    • Martinet, L.1    Smyth, M.J.2
  • 30
    • 1542615649 scopus 로고    scopus 로고
    • Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future
    • 15039756,. PMID
    • Vivier E, Anfossi N. Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Nat Rev Immunol. 2004;4:190-8. doi:10.1038/nri1306. PMID:15039756
    • (2004) Nat Rev Immunol , vol.4 , pp. 190-198
    • Vivier, E.1    Anfossi, N.2
  • 31
    • 84858784892 scopus 로고    scopus 로고
    • Targeting natural killer cells and natural killer T cells in cancer
    • 22437937,. PMID
    • Vivier E, Ugolini S, Blaise D, Chabannon C, Brossay L. Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol. 2012;12:239-52. doi:10.1038/nri3174. PMID:22437937
    • (2012) Nat Rev Immunol , vol.12 , pp. 239-252
    • Vivier, E.1    Ugolini, S.2    Blaise, D.3    Chabannon, C.4    Brossay, L.5
  • 32
    • 84944277572 scopus 로고    scopus 로고
    • Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells
    • 26140242,. PMID
    • Wu AA, Drake V, Huang HS, Chiu S, Zheng L. Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells. Oncoimmunology. 2015;4:e1016700. doi:10.1080/2162402X.2015.1016700. PMID:26140242
    • (2015) Oncoimmunology , vol.4 , pp. 1016700
    • Wu, A.A.1    Drake, V.2    Huang, H.S.3    Chiu, S.4    Zheng, L.5
  • 33
    • 84982144414 scopus 로고    scopus 로고
    • Regulatory circuits of T cell function in cancer
    • 27526640,. PMID
    • Speiser DE, Ho PC, Verdeil G. Regulatory circuits of T cell function in cancer. Nat Rev Immunol. 2016;16:599-611. doi:10.1038/nri.2016.80. PMID:27526640
    • (2016) Nat Rev Immunol , vol.16 , pp. 599-611
    • Speiser, D.E.1    Ho, P.C.2    Verdeil, G.3
  • 34
    • 84945451852 scopus 로고    scopus 로고
    • Immunological hallmarks of stromal cells in the tumour microenvironment
    • 26471778,. PMID
    • Turley SJ, Cremasco V, Astarita JL. Immunological hallmarks of stromal cells in the tumour microenvironment. Nat Rev Immunol. 2015;15:669-82. doi:10.1038/nri3902. PMID:26471778
    • (2015) Nat Rev Immunol , vol.15 , pp. 669-682
    • Turley, S.J.1    Cremasco, V.2    Astarita, J.L.3
  • 38
    • 85010791215 scopus 로고    scopus 로고
    • Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
    • 27974686,. PMID
    • Kroemer G, Galluzzi L. Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors. Oncotarget. 2017;8:5686-91. PMID:27974686
    • (2017) Oncotarget , vol.8 , pp. 5686-5691
    • Kroemer, G.1    Galluzzi, L.2
  • 39
    • 85017446141 scopus 로고    scopus 로고
    • Immunotherapy: Hiding in plain sight: immune escape in the era of targeted T-cell-based immunotherapies
    • 28397826,. PMID
    • Daniyan AF, Brentjens RJ. Immunotherapy: Hiding in plain sight: immune escape in the era of targeted T-cell-based immunotherapies. Nat Rev Clin Oncol. 2017;14:333-4. doi:10.1038/nrclinonc.2017.49. PMID:28397826
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 333-334
    • Daniyan, A.F.1    Brentjens, R.J.2
  • 41
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • 22437870,. PMID
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252-64. doi:10.1038/nrc3239. PMID:22437870
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 42
    • 85029354547 scopus 로고    scopus 로고
    • Monitoring immune-checkpoint blockade: response evaluation and biomarker development
    • 28653677,;in press. PMID
    • Nishino M, Ramaiya NH, Hatabu H, Hodi FS. Monitoring immune-checkpoint blockade: response evaluation and biomarker development. Nat Rev Clin Oncol. 2017;in press. doi:10.1038/nrclinonc.2017.88. PMID:28653677
    • (2017) Nat Rev Clin Oncol
    • Nishino, M.1    Ramaiya, N.H.2    Hatabu, H.3    Hodi, F.S.4
  • 43
    • 84963621254 scopus 로고    scopus 로고
    • Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
    • 27079802,. PMID
    • Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016;16:275-87. doi:10.1038/nrc.2016.36. PMID:27079802
    • (2016) Nat Rev Cancer , vol.16 , pp. 275-287
    • Topalian, S.L.1    Taube, J.M.2    Anders, R.A.3    Pardoll, D.M.4
  • 44
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • 25860605,. PMID
    • Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161:205-14. doi:10.1016/j.cell.2015.03.030. PMID:25860605
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 45
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • 25838373,. PMID
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348:56-61. doi:10.1126/science.aaa8172. PMID:25838373
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 46
    • 80054875641 scopus 로고    scopus 로고
    • Novel cancer immunotherapy agents with survival benefit: recent successes and next steps
    • 22020206,. PMID
    • Sharma P, Wagner K, Wolchok JD, Allison JP. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Nat Rev Cancer. 2011;11:805-12. doi:10.1038/nrc3153. PMID:22020206
    • (2011) Nat Rev Cancer , vol.11 , pp. 805-812
    • Sharma, P.1    Wagner, K.2    Wolchok, J.D.3    Allison, J.P.4
  • 47
    • 84966738229 scopus 로고    scopus 로고
    • Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
    • 27192563,. PMID
    • Schildberg FA, Klein SR, Freeman GJ, Sharpe AH. Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family. Immunity. 2016;44:955-72. doi:10.1016/j.immuni.2016.05.002. PMID:27192563
    • (2016) Immunity , vol.44 , pp. 955-972
    • Schildberg, F.A.1    Klein, S.R.2    Freeman, G.J.3    Sharpe, A.H.4
  • 50
    • 84879625854 scopus 로고    scopus 로고
    • New checkpoint inhibitors ride the immunotherapy tsunami
    • 23812256,. PMID
    • Mullard A. New checkpoint inhibitors ride the immunotherapy tsunami. Nat Rev Drug Discov. 2013;12:489-92. doi:10.1038/nrd4066. PMID:23812256
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 489-492
    • Mullard, A.1
  • 52
    • 85008395037 scopus 로고    scopus 로고
    • Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity
    • 28057932,. PMID
    • Lesterhuis WJ, Bosco A, Millward MJ, Small M, Nowak AK, Lake RA. Dynamic versus static biomarkers in cancer immune checkpoint blockade: unravelling complexity. Nat Rev Drug Discov. 2017;16:264-72. doi:10.1038/nrd.2016.233. PMID:28057932
    • (2017) Nat Rev Drug Discov , vol.16 , pp. 264-272
    • Lesterhuis, W.J.1    Bosco, A.2    Millward, M.J.3    Small, M.4    Nowak, A.K.5    Lake, R.A.6
  • 53
    • 84956619454 scopus 로고    scopus 로고
    • Acquired resistance to immunotherapy and future challenges
    • 26822578,. PMID
    • Restifo NP, Smyth MJ, Snyder A. Acquired resistance to immunotherapy and future challenges. Nat Rev Cancer. 2016;16:121-6. doi:10.1038/nrc.2016.2. PMID:26822578
    • (2016) Nat Rev Cancer , vol.16 , pp. 121-126
    • Restifo, N.P.1    Smyth, M.J.2    Snyder, A.3
  • 54
    • 85014681380 scopus 로고    scopus 로고
    • Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
    • 28251903, et al.,. PMID
    • Roh W, Chen PL, Reuben A, Spencer CN, Prieto PA, Miller JP, Gopalakrishnan V, Wang F, Cooper ZA, Reddy SM, et al. Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Sci Transl Med. 2017;9:eaah3560. doi:10.1126/scitranslmed.aah3560. PMID:28251903
    • (2017) Sci Transl Med , vol.9 , pp. aah3560
    • Roh, W.1    Chen, P.L.2    Reuben, A.3    Spencer, C.N.4    Prieto, P.A.5    Miller, J.P.6    Gopalakrishnan, V.7    Wang, F.8    Cooper, Z.A.9    Reddy, S.M.10
  • 55
    • 85014004127 scopus 로고    scopus 로고
    • Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy
    • 27821490, et al.,. PMID
    • Wang X, Schoenhals JE, Li A, Valdecanas DR, Ye H, Zang F, Tang C, Tang M, Liu CG, Liu X, et al. Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy. Cancer Res. 2017;77:839-50. doi:10.1158/0008-5472.CAN-15-3142. PMID:27821490
    • (2017) Cancer Res , vol.77 , pp. 839-850
    • Wang, X.1    Schoenhals, J.E.2    Li, A.3    Valdecanas, D.R.4    Ye, H.5    Zang, F.6    Tang, C.7    Tang, M.8    Liu, C.G.9    Liu, X.10
  • 56
    • 84990849572 scopus 로고    scopus 로고
    • Loss of IFN-gamma Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
    • 27667683, et al.,. PMID
    • Gao J, Shi LZ, Zhao H, Chen J, Xiong L, He Q, Chen T, Roszik J, Bernatchez C, Woodman SE, et al. Loss of IFN-gamma Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy. Cell. 2016;167:397-404.e9. doi:10.1016/j.cell.2016.08.069. PMID:27667683
    • (2016) Cell , vol.167 , pp. 397-404
    • Gao, J.1    Shi, L.Z.2    Zhao, H.3    Chen, J.4    Xiong, L.5    He, Q.6    Chen, T.7    Roszik, J.8    Bernatchez, C.9    Woodman, S.E.10
  • 57
    • 85012158583 scopus 로고    scopus 로고
    • Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
    • 28187290,. PMID
    • Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A. Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy. Cell. 2017;168:707-23. doi:10.1016/j.cell.2017.01.017. PMID:28187290
    • (2017) Cell , vol.168 , pp. 707-723
    • Sharma, P.1    Hu-Lieskovan, S.2    Wargo, J.A.3    Ribas, A.4
  • 60
    • 85013925425 scopus 로고    scopus 로고
    • Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma
    • 28228279, et al.,. PMID
    • George S, Miao D, Demetri GD, Adeegbe D, Rodig SJ, Shukla S, Lipschitz M, Amin-Mansour A, Raut CP, Carter SL, et al. Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma. Immunity. 2017;46:197-204. doi:10.1016/j.immuni.2017.02.001. PMID:28228279
    • (2017) Immunity , vol.46 , pp. 197-204
    • George, S.1    Miao, D.2    Demetri, G.D.3    Adeegbe, D.4    Rodig, S.J.5    Shukla, S.6    Lipschitz, M.7    Amin-Mansour, A.8    Raut, C.P.9    Carter, S.L.10
  • 63
    • 84940890382 scopus 로고    scopus 로고
    • Big opportunities for small molecules in immuno-oncology
    • 26228631,. PMID
    • Adams JL, Smothers J, Srinivasan R, Hoos A. Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov. 2015;14:603-22. doi:10.1038/nrd4596. PMID:26228631
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 603-622
    • Adams, J.L.1    Smothers, J.2    Srinivasan, R.3    Hoos, A.4
  • 64
    • 84960366855 scopus 로고    scopus 로고
    • Development of immuno-oncology drugs–from CTLA4 to PD1 to the next generations
    • 26965203,. PMID
    • Hoos A. Development of immuno-oncology drugs–from CTLA4 to PD1 to the next generations. Nat Rev Drug Discov. 2016;15:235-47. doi:10.1038/nrd.2015.35. PMID:26965203
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 235-247
    • Hoos, A.1
  • 65
    • 84984677958 scopus 로고    scopus 로고
    • Engineered T cells: the promise and challenges of cancer immunotherapy
    • 27550819,. PMID
    • Fesnak AD, June CH, Levine BL. Engineered T cells: the promise and challenges of cancer immunotherapy. Nat Rev Cancer. 2016;16:566-81. doi:10.1038/nrc.2016.97. PMID:27550819
    • (2016) Nat Rev Cancer , vol.16 , pp. 566-581
    • Fesnak, A.D.1    June, C.H.2    Levine, B.L.3
  • 66
    • 84940824279 scopus 로고    scopus 로고
    • Oncolytic viruses: a new class of immunotherapy drugs
    • 26323545,. PMID
    • Kaufman HL, Kohlhapp FJ, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs. Nat Rev Drug Discov. 2015;14:642-62. doi:10.1038/nrd4663. PMID:26323545
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 642-662
    • Kaufman, H.L.1    Kohlhapp, F.J.2    Zloza, A.3
  • 67
    • 84940378016 scopus 로고    scopus 로고
    • Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS
    • 26320067,. PMID
    • Sanmamed MF, Pastor F, Rodriguez A, Perez-Gracia JL, Rodriguez-Ruiz ME, Jure-Kunkel M, Melero I. Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS. Semin Oncol. 2015;42:640-55. doi:10.1053/j.seminoncol.2015.05.014. PMID:26320067
    • (2015) Semin Oncol , vol.42 , pp. 640-655
    • Sanmamed, M.F.1    Pastor, F.2    Rodriguez, A.3    Perez-Gracia, J.L.4    Rodriguez-Ruiz, M.E.5    Jure-Kunkel, M.6    Melero, I.7
  • 70
    • 84994876820 scopus 로고    scopus 로고
    • Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format
    • 27999756,. PMID
    • Fellermeier S, Beha N, Meyer JE, Ring S, Bader S, Kontermann RE, Muller D. Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format. Oncoimmunology. 2016;5:e1238540. doi:10.1080/2162402X.2016.1238540. PMID:27999756
    • (2016) Oncoimmunology , vol.5 , pp. 1238540
    • Fellermeier, S.1    Beha, N.2    Meyer, J.E.3    Ring, S.4    Bader, S.5    Kontermann, R.E.6    Muller, D.7
  • 71
    • 84942308926 scopus 로고    scopus 로고
    • Development of Next-Generation Immunomodulatory Antibodies for Cancer Therapy through Optimization of the IgG Framework
    • 26373272,. PMID
    • Offringa R, Glennie MJ. Development of Next-Generation Immunomodulatory Antibodies for Cancer Therapy through Optimization of the IgG Framework. Cancer Cell. 2015;28:273-5. doi:10.1016/j.ccell.2015.08.008. PMID:26373272
    • (2015) Cancer Cell , vol.28 , pp. 273-275
    • Offringa, R.1    Glennie, M.J.2
  • 72
    • 84961223438 scopus 로고    scopus 로고
    • Therapeutic targeting of CD70 and CD27
    • 26914723,. PMID
    • Wajant H. Therapeutic targeting of CD70 and CD27. Expert Opin Ther Targets. 2016;20:959-73. doi:10.1517/14728222.2016.1158812. PMID:26914723
    • (2016) Expert Opin Ther Targets , vol.20 , pp. 959-973
    • Wajant, H.1
  • 73
    • 85015668016 scopus 로고    scopus 로고
    • Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer
    • 28319731,. PMID
    • Bullock TN. Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer. Curr Opin Immunol. 2017;45:82-8. doi:10.1016/j.coi.2017.02.001. PMID:28319731
    • (2017) Curr Opin Immunol , vol.45 , pp. 82-88
    • Bullock, T.N.1
  • 74
    • 84872806869 scopus 로고    scopus 로고
    • The CD70-CD27 axis, a new brake in the T helper 17 cell response
    • 23352216,. PMID
    • Wang X, Dong C. The CD70-CD27 axis, a new brake in the T helper 17 cell response. Immunity. 2013;38:1-3. doi:10.1016/j.immuni.2013.01.005. PMID:23352216
    • (2013) Immunity , vol.38 , pp. 1-3
    • Wang, X.1    Dong, C.2
  • 75
    • 84937852364 scopus 로고    scopus 로고
    • The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy
    • 25550693,. PMID
    • Leung J, Suh WK. The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy. Immune Netw. 2014;14:265-76. doi:10.4110/in.2014.14.6.265. PMID:25550693
    • (2014) Immune Netw , vol.14 , pp. 265-276
    • Leung, J.1    Suh, W.K.2
  • 77
    • 85015665428 scopus 로고    scopus 로고
    • T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
    • 28280247, et al.,. PMID
    • Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355:1428-33. doi:10.1126/science.aaf1292. PMID:28280247
    • (2017) Science , vol.355 , pp. 1428-1433
    • Hui, E.1    Cheung, J.2    Zhu, J.3    Su, X.4    Taylor, M.J.5    Wallweber, H.A.6    Sasmal, D.K.7    Huang, J.8    Kim, J.M.9    Mellman, I.10
  • 78
    • 84874845333 scopus 로고    scopus 로고
    • Agonistic CD40 antibodies and cancer therapy
    • 23460534,. PMID
    • Vonderheide RH, Glennie MJ. Agonistic CD40 antibodies and cancer therapy. Clin Cancer Res. 2013;19:1035-43. doi:10.1158/1078-0432.CCR-12-2064. PMID:23460534
    • (2013) Clin Cancer Res , vol.19 , pp. 1035-1043
    • Vonderheide, R.H.1    Glennie, M.J.2
  • 79
    • 85010917048 scopus 로고    scopus 로고
    • Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists
    • 27927088,. PMID
    • Beatty GL, Li Y, Long KB. Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists. Expert Rev Anticancer Ther. 2017;17:175-86. doi:10.1080/14737140.2017.1270208. PMID:27927088
    • (2017) Expert Rev Anticancer Ther , vol.17 , pp. 175-186
    • Beatty, G.L.1    Li, Y.2    Long, K.B.3
  • 80
    • 84975105592 scopus 로고    scopus 로고
    • CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer
    • 27292635,. PMID
    • Byrne KT, Vonderheide RH. CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer. Cell Rep. 2016;15:2719-32. doi:10.1016/j.celrep.2016.05.058. PMID:27292635
    • (2016) Cell Rep , vol.15 , pp. 2719-2732
    • Byrne, K.T.1    Vonderheide, R.H.2
  • 84
    • 84923537886 scopus 로고    scopus 로고
    • OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal
    • 25763356,. PMID
    • Linch SN, McNamara MJ, Redmond WL. OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal. Front Oncol. 2015;5:34. doi:10.3389/fonc.2015.00034. PMID:25763356
    • (2015) Front Oncol , vol.5 , pp. 34
    • Linch, S.N.1    McNamara, M.J.2    Redmond, W.L.3
  • 85
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    • 15173831,. PMID
    • Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol. 2004;4:420-31. doi:10.1038/nri1371. PMID:15173831
    • (2004) Nat Rev Immunol , vol.4 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.D.3
  • 86
    • 84978543393 scopus 로고    scopus 로고
    • Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity
    • 27622048,. PMID
    • Souza-Fonseca-Guimaraes F, Blake SJ, Makkouk A, Chester C, Kohrt HE, Smyth MJ. Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity. Oncoimmunology. 2016;5:e1192740. doi:10.1080/2162402X.2016.1192740. PMID:27622048
    • (2016) Oncoimmunology , vol.5 , pp. 1192740
    • Souza-Fonseca-Guimaraes, F.1    Blake, S.J.2    Makkouk, A.3    Chester, C.4    Kohrt, H.E.5    Smyth, M.J.6
  • 87
    • 84952932933 scopus 로고    scopus 로고
    • Rationale for anti-CD137 cancer immunotherapy
    • 26751393,. PMID
    • Makkouk A, Chester C, Kohrt HE. Rationale for anti-CD137 cancer immunotherapy. Eur J Cancer. 2016;54:112-9. doi:10.1016/j.ejca.2015.09.026. PMID:26751393
    • (2016) Eur J Cancer , vol.54 , pp. 112-119
    • Makkouk, A.1    Chester, C.2    Kohrt, H.E.3
  • 88
    • 84962157662 scopus 로고    scopus 로고
    • 4-1BB agonism: adding the accelerator to cancer immunotherapy
    • 27034234,. PMID
    • Chester C, Ambulkar S, Kohrt HE. 4-1BB agonism: adding the accelerator to cancer immunotherapy. Cancer Immunol Immunother. 2016;65:1243-8. doi:10.1007/s00262-016-1829-2. PMID:27034234
    • (2016) Cancer Immunol Immunother , vol.65 , pp. 1243-1248
    • Chester, C.1    Ambulkar, S.2    Kohrt, H.E.3
  • 90
    • 84984604984 scopus 로고    scopus 로고
    • Rationale for anti-GITR cancer immunotherapy
    • 27591414,. PMID
    • Knee DA, Hewes B, Brogdon JL. Rationale for anti-GITR cancer immunotherapy. Eur J Cancer. 2016;67:1-10. doi:10.1016/j.ejca.2016.06.028. PMID:27591414
    • (2016) Eur J Cancer , vol.67 , pp. 1-10
    • Knee, D.A.1    Hewes, B.2    Brogdon, J.L.3
  • 92
    • 79952770456 scopus 로고    scopus 로고
    • Anti-GITR antibodies–potential clinical applications for tumor immunotherapy
    • 21154120,. PMID
    • Schaer DA, Cohen AD, Wolchok JD. Anti-GITR antibodies–potential clinical applications for tumor immunotherapy. Curr Opin Investig Drugs. 2010;11:1378-86. PMID:21154120
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1378-1386
    • Schaer, D.A.1    Cohen, A.D.2    Wolchok, J.D.3
  • 93
    • 77952348017 scopus 로고    scopus 로고
    • Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)
    • 20116985,. PMID
    • Simpson TR, Quezada SA, Allison JP. Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). Curr Opin Immunol. 2010;22:326-32. doi:10.1016/j.coi.2010.01.001. PMID:20116985
    • (2010) Curr Opin Immunol , vol.22 , pp. 326-332
    • Simpson, T.R.1    Quezada, S.A.2    Allison, J.P.3
  • 94
    • 84962702960 scopus 로고    scopus 로고
    • ICOS Expression as Immunologic Marker in Immune Activating Monoclonal Antibodies
    • 27033223,. PMID
    • Danielli R, Cutaia O, Fazio C, Bertocci E, Fonsatti E, Maio M, Calabro L. ICOS Expression as Immunologic Marker in Immune Activating Monoclonal Antibodies. Methods Mol Biol. 2016;1393:133-9. doi:10.1007/978-1-4939-3338-9_13. PMID:27033223
    • (2016) Methods Mol Biol , vol.1393 , pp. 133-139
    • Danielli, R.1    Cutaia, O.2    Fazio, C.3    Bertocci, E.4    Fonsatti, E.5    Maio, M.6    Calabro, L.7
  • 95
    • 84897940775 scopus 로고    scopus 로고
    • Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy
    • 24687957,. PMID
    • Fan X, Quezada SA, Sepulveda MA, Sharma P, Allison JP. Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy. J Exp Med. 2014;211:715-25. doi:10.1084/jem.20130590. PMID:24687957
    • (2014) J Exp Med , vol.211 , pp. 715-725
    • Fan, X.1    Quezada, S.A.2    Sepulveda, M.A.3    Sharma, P.4    Allison, J.P.5
  • 96
    • 84962795027 scopus 로고    scopus 로고
    • Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells
    • 27141390,. PMID
    • van Dodewaard-de Jong JM, Santegoets SJ, van de Ven PM, Versluis J, Verheul HM, de Gruijl TD, Gerritsen WR, van den Eertwegh AJ. Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells. Oncoimmunology. 2016;5:e1105431. doi:10.1080/2162402X.2015.1105431. PMID:27141390
    • (2016) Oncoimmunology , vol.5 , pp. 1105431
    • van Dodewaard-de Jong, J.M.1    Santegoets, S.J.2    van de Ven, P.M.3    Versluis, J.4    Verheul, H.M.5    de Gruijl, T.D.6    Gerritsen, W.R.7    van den Eertwegh, A.J.8
  • 97
    • 84925121085 scopus 로고    scopus 로고
    • ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity
    • 25769613,. PMID
    • Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O. ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity. 2015;42:538-51. doi:10.1016/j.immuni.2015.02.007. PMID:25769613
    • (2015) Immunity , vol.42 , pp. 538-551
    • Maazi, H.1    Patel, N.2    Sankaranarayanan, I.3    Suzuki, Y.4    Rigas, D.5    Soroosh, P.6    Freeman, G.J.7    Sharpe, A.H.8    Akbari, O.9
  • 99
    • 84944567385 scopus 로고    scopus 로고
    • Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma
    • 26587319,. PMID
    • Ruf M, Moch H, Schraml P. Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma. Oncoimmunology. 2015;4:e1049805. doi:10.1080/2162402X.2015.1049805. PMID:26587319
    • (2015) Oncoimmunology , vol.4 , pp. 1049805
    • Ruf, M.1    Moch, H.2    Schraml, P.3
  • 100
    • 84883403813 scopus 로고    scopus 로고
    • CD70 is downregulated by interaction with CD27
    • 23913967,. PMID
    • Kuka M, Munitic I, Giardino Torchia ML, Ashwell JD. CD70 is downregulated by interaction with CD27. J Immunol. 2013;191:2282-9. doi:10.4049/jimmunol.1300868. PMID:23913967
    • (2013) J Immunol , vol.191 , pp. 2282-2289
    • Kuka, M.1    Munitic, I.2    Giardino Torchia, M.L.3    Ashwell, J.D.4
  • 101
    • 84872827286 scopus 로고    scopus 로고
    • The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity
    • 23159439,. PMID
    • Coquet JM, Middendorp S, van der Horst G, Kind J, Veraar EA, Xiao Y, Jacobs H, Borst J. The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. Immunity. 2013;38:53-65. doi:10.1016/j.immuni.2012.09.009. PMID:23159439
    • (2013) Immunity , vol.38 , pp. 53-65
    • Coquet, J.M.1    Middendorp, S.2    van der Horst, G.3    Kind, J.4    Veraar, E.A.5    Xiao, Y.6    Jacobs, H.7    Borst, J.8
  • 102
    • 84872724158 scopus 로고    scopus 로고
    • CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus
    • 23269247,. PMID
    • Munitic I, Kuka M, Allam A, Scoville JP, Ashwell JD. CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. J Immunol. 2013;190:1169-79. doi:10.4049/jimmunol.1202353. PMID:23269247
    • (2013) J Immunol , vol.190 , pp. 1169-1179
    • Munitic, I.1    Kuka, M.2    Allam, A.3    Scoville, J.P.4    Ashwell, J.D.5
  • 103
    • 84942300594 scopus 로고    scopus 로고
    • Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma
    • 25949922,. PMID
    • Sato Y, Shimizu K, Shinga J, Hidaka M, Kawano F, Kakimi K, Yamasaki S, Asakura M, Fujii SI. Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma. Oncoimmunology. 2015;4:e995541. doi:10.1080/2162402X.2014.995541. PMID:25949922
    • (2015) Oncoimmunology , vol.4 , pp. 995541
    • Sato, Y.1    Shimizu, K.2    Shinga, J.3    Hidaka, M.4    Kawano, F.5    Kakimi, K.6    Yamasaki, S.7    Asakura, M.8    Fujii, S.I.9
  • 105
    • 84864808097 scopus 로고    scopus 로고
    • Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells
    • 22798683,. PMID
    • Bak SP, Barnkob MS, Bai A, Higham EM, Wittrup KD, Chen J. Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells. J Immunol. 2012;189:1708-16. doi:10.4049/jimmunol.1201271. PMID:22798683
    • (2012) J Immunol , vol.189 , pp. 1708-1716
    • Bak, S.P.1    Barnkob, M.S.2    Bai, A.3    Higham, E.M.4    Wittrup, K.D.5    Chen, J.6
  • 106
    • 84995615046 scopus 로고    scopus 로고
    • T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells
    • 27622331, et al.,. PMID
    • Marigo I, Zilio S, Desantis G, Mlecnik B, Agnellini AH, Ugel S, Sasso MS, Qualls JE, Kratochvill F, Zanovello P, et al. T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells. Cancer Cell. 2016;30:377-90. doi:10.1016/j.ccell.2016.08.004. PMID:27622331
    • (2016) Cancer Cell , vol.30 , pp. 377-390
    • Marigo, I.1    Zilio, S.2    Desantis, G.3    Mlecnik, B.4    Agnellini, A.H.5    Ugel, S.6    Sasso, M.S.7    Qualls, J.E.8    Kratochvill, F.9    Zanovello, P.10
  • 108
    • 84979902229 scopus 로고    scopus 로고
    • Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy
    • 27323820,. PMID
    • Shin CA, Cho HW, Shin AR, Sohn HJ, Cho HI, Kim TG. Co-expression of CD40L with CD70 or OX40L increases B-cell viability and antitumor efficacy. Oncotarget. 2016;7:46173-86. doi:10.18632/oncotarget.10068. PMID:27323820
    • (2016) Oncotarget , vol.7 , pp. 46173-46186
    • Shin, C.A.1    Cho, H.W.2    Shin, A.R.3    Sohn, H.J.4    Cho, H.I.5    Kim, T.G.6
  • 109
    • 84897032564 scopus 로고    scopus 로고
    • CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes
    • 24481488,. PMID
    • Liljenfeldt L, Dieterich LC, Dimberg A, Mangsbo SM, Loskog AS. CD40L gene therapy tilts the myeloid cell profile and promotes infiltration of activated T lymphocytes. Cancer Gene Ther. 2014;21:95-102. doi:10.1038/cgt.2014.2. PMID:24481488
    • (2014) Cancer Gene Ther , vol.21 , pp. 95-102
    • Liljenfeldt, L.1    Dieterich, L.C.2    Dimberg, A.3    Mangsbo, S.M.4    Loskog, A.S.5
  • 110
    • 77953724187 scopus 로고    scopus 로고
    • OX40 (CD134) and OX40L
    • 19760068,. PMID
    • Gough MJ, Weinberg AD. OX40 (CD134) and OX40L. Adv Exp Med Biol. 2009;647:94-107. doi:10.1007/978-0-387-89520-8_6. PMID:19760068
    • (2009) Adv Exp Med Biol , vol.647 , pp. 94-107
    • Gough, M.J.1    Weinberg, A.D.2
  • 112
    • 79952508760 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway
    • 21397857,. PMID
    • Godefroy E, Manches O, Dreno B, Hochman T, Roldoi:nitzky L, Labarriere N, Guilloux Y, Goldberg J, Jotereau F, Bhardwaj N. Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway. Cancer Cell. 2011;19:333-46. doi:10.1016/j.ccr.2011.01.037. PMID:21397857
    • (2011) Cancer Cell , vol.19 , pp. 333-346
    • Godefroy, E.1    Manches, O.2    Dreno, B.3    Hochman, T.4    Roldoinitzky, L.5    Labarriere, N.6    Guilloux, Y.7    Goldberg, J.8    Jotereau, F.9    Bhardwaj, N.10
  • 113
    • 27744446078 scopus 로고    scopus 로고
    • Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL
    • 16272289,. PMID
    • Serghides L, Bukczynski J, Wen T, Wang C, Routy JP, Boulassel MR, Sekaly RP, Ostrowski M, Bernard NF, Watts TH. Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL. J Immunol. 2005;175:6368-77. doi:10.4049/jimmunol.175.10.6368. PMID:16272289
    • (2005) J Immunol , vol.175 , pp. 6368-6377
    • Serghides, L.1    Bukczynski, J.2    Wen, T.3    Wang, C.4    Routy, J.P.5    Boulassel, M.R.6    Sekaly, R.P.7    Ostrowski, M.8    Bernard, N.F.9    Watts, T.H.10
  • 114
    • 85022188647 scopus 로고    scopus 로고
    • SA-4-1BBL/MPL as a novel immune adjuvant platform to combat cancer
    • 26942082,. PMID
    • Srivastava AK, Yolcu ES, Dinc G, Sharma RK, Shirwan H. SA-4-1BBL/MPL as a novel immune adjuvant platform to combat cancer. Oncoimmunology. 2016;5:e1064580. doi:10.1080/2162402X.2015.1064580. PMID:26942082
    • (2016) Oncoimmunology , vol.5 , pp. 1064580
    • Srivastava, A.K.1    Yolcu, E.S.2    Dinc, G.3    Sharma, R.K.4    Shirwan, H.5
  • 115
    • 84973110970 scopus 로고    scopus 로고
    • CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth
    • 27471634,. PMID
    • Rajendran S, Ho WT, Schwarz H. CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth. Oncoimmunology. 2016;5:e1160188. doi:10.1080/2162402X.2016.1160188. PMID:27471634
    • (2016) Oncoimmunology , vol.5 , pp. 1160188
    • Rajendran, S.1    Ho, W.T.2    Schwarz, H.3
  • 116
    • 0033560179 scopus 로고    scopus 로고
    • 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine
    • 10202049,. PMID
    • Guinn BA, DeBenedette MA, Watts TH, Berinstein NL. 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. J Immunol. 1999;162:5003-10. PMID:10202049
    • (1999) J Immunol , vol.162 , pp. 5003-5010
    • Guinn, B.A.1    DeBenedette, M.A.2    Watts, T.H.3    Berinstein, N.L.4
  • 117
    • 34249077931 scopus 로고    scopus 로고
    • Cell surface 4-1BBL mediates sequential signaling pathways ‘downstream’ of TLR and is required for sustained TNF production in macrophages
    • 17496895,. PMID
    • Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J. Cell surface 4-1BBL mediates sequential signaling pathways ‘downstream’ of TLR and is required for sustained TNF production in macrophages. Nat Immunol. 2007;8:601-9. doi:10.1038/ni1471. PMID:17496895
    • (2007) Nat Immunol , vol.8 , pp. 601-609
    • Kang, Y.J.1    Kim, S.O.2    Shimada, S.3    Otsuka, M.4    Seit-Nebi, A.5    Kwon, B.S.6    Watts, T.H.7    Han, J.8
  • 118
    • 84858236143 scopus 로고    scopus 로고
    • Pharmacological modulation of GITRL/GITR system: therapeutic perspectives
    • 22029729,. PMID
    • Nocentini G, Ronchetti S, Petrillo MG, Riccardi C. Pharmacological modulation of GITRL/GITR system: therapeutic perspectives. Br J Pharmacol. 2012;165:2089-99. doi:10.1111/j.1476-5381.2011.01753.x. PMID:22029729
    • (2012) Br J Pharmacol , vol.165 , pp. 2089-2099
    • Nocentini, G.1    Ronchetti, S.2    Petrillo, M.G.3    Riccardi, C.4
  • 119
    • 84944578399 scopus 로고    scopus 로고
    • GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo
    • 26587321, et al.,. PMID
    • Pedroza-Gonzalez A, Zhou G, Singh SP, Boor PP, Pan Q, Grunhagen D, de Jonge J, Tran TK, Verhoef C, JN IJ, et al. GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo. Oncoimmunology. 2015;4:e1051297. doi:10.1080/2162402X.2015.1051297. PMID:26587321
    • (2015) Oncoimmunology , vol.4 , pp. 1051297
    • Pedroza-Gonzalez, A.1    Zhou, G.2    Singh, S.P.3    Boor, P.P.4    Pan, Q.5    Grunhagen, D.6    de Jonge, J.7    Tran, T.K.8    Verhoef, C.9    Jn, I.10
  • 120
    • 84975879195 scopus 로고    scopus 로고
    • The clinical impact of ICOS signal in colorectal cancer patients
    • 27467961,. PMID
    • Zhang Y, Luo Y, Qin SL, Mu YF, Qi Y, Yu MH, Zhong M. The clinical impact of ICOS signal in colorectal cancer patients. Oncoimmunology. 2016;5:e1141857. doi:10.1080/2162402X.2016.1141857. PMID:27467961
    • (2016) Oncoimmunology , vol.5 , pp. 1141857
    • Zhang, Y.1    Luo, Y.2    Qin, S.L.3    Mu, Y.F.4    Qi, Y.5    Yu, M.H.6    Zhong, M.7
  • 121
    • 80051694786 scopus 로고    scopus 로고
    • The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy
    • 21708958,. PMID
    • Fu T, He Q, Sharma P. The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy. Cancer Res. 2011;71:5445-54. doi:10.1158/0008-5472.CAN-11-1138. PMID:21708958
    • (2011) Cancer Res , vol.71 , pp. 5445-5454
    • Fu, T.1    He, Q.2    Sharma, P.3
  • 122
    • 84923778281 scopus 로고    scopus 로고
    • T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction
    • 25317561,. PMID
    • Liu D, Xu H, Shih C, Wan Z, Ma X, Ma W, Luo D, Qi H. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature 2015;517:214-8. doi:10.1038/nature13803. PMID:25317561
    • (2015) Nature , vol.517 , pp. 214-218
    • Liu, D.1    Xu, H.2    Shih, C.3    Wan, Z.4    Ma, X.5    Ma, W.6    Luo, D.7    Qi, H.8
  • 123
    • 45949091620 scopus 로고    scopus 로고
    • ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival
    • 18390727,. PMID
    • Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol 2008;180:5448-56. doi:10.4049/jimmunol.180.8.5448. PMID:18390727
    • (2008) J Immunol , vol.180 , pp. 5448-5456
    • Akbari, O.1    Stock, P.2    Meyer, E.H.3    Freeman, G.J.4    Sharpe, A.H.5    Umetsu, D.T.6    DeKruyff, R.H.7
  • 124
    • 84885466006 scopus 로고    scopus 로고
    • Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice
    • 24026078, et al.,. PMID
    • He LZ, Prostak N, Thomas LJ, Vitale L, Weidlick J, Crocker A, Pilsmaker CD, Round SM, Tutt A, Glennie MJ, et al. Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice. J Immunol 2013;191:4174-83. doi:10.4049/jimmunol.1300409. PMID:24026078
    • (2013) J Immunol , vol.191 , pp. 4174-4183
    • He, L.Z.1    Prostak, N.2    Thomas, L.J.3    Vitale, L.4    Weidlick, J.5    Crocker, A.6    Pilsmaker, C.D.7    Round, S.M.8    Tutt, A.9    Glennie, M.J.10
  • 126
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    • 18362171,. PMID
    • Piconese S, Valzasina B, Colombo MP. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med 2008;205:825-39. doi:10.1084/jem.20071341. PMID:18362171
    • (2008) J Exp Med , vol.205 , pp. 825-839
    • Piconese, S.1    Valzasina, B.2    Colombo, M.P.3
  • 127
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • 11812990,. PMID
    • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002;3:135-42. doi:10.1038/ni759. PMID:11812990
    • (2002) Nat Immunol , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 128
    • 84897933432 scopus 로고    scopus 로고
    • GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability
    • 24416730, et al.,. PMID
    • Schaer DA, Budhu S, Liu C, Bryson C, Malandro N, Cohen A, Zhong H, Yang X, Houghton AN, Merghoub T, et al. GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability. Cancer Immunol Res 2013;1:320-31. doi:10.1158/2326-6066.CIR-13-0086. PMID:24416730
    • (2013) Cancer Immunol Res , vol.1 , pp. 320-331
    • Schaer, D.A.1    Budhu, S.2    Liu, C.3    Bryson, C.4    Malandro, N.5    Cohen, A.6    Zhong, H.7    Yang, X.8    Houghton, A.N.9    Merghoub, T.10
  • 129
    • 84941022982 scopus 로고    scopus 로고
    • Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells
    • 26280119, et al.,. PMID
    • Kim IK, Kim BS, Koh CH, Seok JW, Park JS, Shin KS, Bae EA, Lee GE, Jeon H, Cho J, et al. Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells. Nat Med. 2015;21:1010-7. doi:10.1038/nm.3922. PMID:26280119
    • (2015) Nat Med , vol.21 , pp. 1010-1017
    • Kim, I.K.1    Kim, B.S.2    Koh, C.H.3    Seok, J.W.4    Park, J.S.5    Shin, K.S.6    Bae, E.A.7    Lee, G.E.8    Jeon, H.9    Cho, J.10
  • 130
    • 84964689401 scopus 로고    scopus 로고
    • GITR drives TH9-mediated antitumor immunity
    • 27467921,. PMID
    • Kim IK, Chung Y, Kang CY. GITR drives TH9-mediated antitumor immunity. Oncoimmunology. 2016;5:e1122862. doi:10.1080/2162402X.2015.1122862. PMID:27467921
    • (2016) Oncoimmunology , vol.5 , pp. 1122862
    • Kim, I.K.1    Chung, Y.2    Kang, C.Y.3
  • 132
    • 84976382144 scopus 로고    scopus 로고
    • Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer
    • 27622025, et al.,. PMID
    • Timperi E, Pacella I, Schinzari V, Focaccetti C, Sacco L, Farelli F, Caronna R, Del Bene G, Longo F, Ciardi A, et al. Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer. Oncoimmunology. 2016;5:e1175800. doi:10.1080/2162402X.2016.1175800. PMID:27622025
    • (2016) Oncoimmunology , vol.5 , pp. 1175800
    • Timperi, E.1    Pacella, I.2    Schinzari, V.3    Focaccetti, C.4    Sacco, L.5    Farelli, F.6    Caronna, R.7    Del Bene, G.8    Longo, F.9    Ciardi, A.10
  • 133
    • 48549099849 scopus 로고    scopus 로고
    • OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor
    • 18593921,. PMID
    • Gough MJ, Ruby CE, Redmond WL, Dhungel B, Brown A, Weinberg AD. OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor. Cancer Res. 2008;68:5206-15. doi:10.1158/0008-5472.CAN-07-6484. PMID:18593921
    • (2008) Cancer Res , vol.68 , pp. 5206-5215
    • Gough, M.J.1    Ruby, C.E.2    Redmond, W.L.3    Dhungel, B.4    Brown, A.5    Weinberg, A.D.6
  • 134
    • 84941670561 scopus 로고    scopus 로고
    • GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation
    • 26365427, et al.,. PMID
    • Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, Minze L, Fu YX, Ghobrial RM, Liu W, et al. GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation. Nat Commun. 2015;6:8266. doi:10.1038/ncomms9266. PMID:26365427
    • (2015) Nat Commun , vol.6 , pp. 8266
    • Xiao, X.1    Shi, X.2    Fan, Y.3    Zhang, X.4    Wu, M.5    Lan, P.6    Minze, L.7    Fu, Y.X.8    Ghobrial, R.M.9    Liu, W.10
  • 135
    • 84958625170 scopus 로고    scopus 로고
    • Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted
    • 26423152,. PMID
    • Kim YH, Shin SM, Choi BK, Oh HS, Kim CH, Lee SJ, Kim KH, Lee DG, Park SH, Kwon BS. Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted. J Immunol. 2015;195:4721-9. doi:10.4049/jimmunol.1403076. PMID:26423152
    • (2015) J Immunol , vol.195 , pp. 4721-4729
    • Kim, Y.H.1    Shin, S.M.2    Choi, B.K.3    Oh, H.S.4    Kim, C.H.5    Lee, S.J.6    Kim, K.H.7    Lee, D.G.8    Park, S.H.9    Kwon, B.S.10
  • 136
    • 85015861938 scopus 로고    scopus 로고
    • Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy
    • 28122327,. PMID
    • Mahne AE, Mauze S, Joyce-Shaikh B, Xia J, Bowman EP, Beebe AM, Cua DJ, Jain R. Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy. Cancer Res. 2017;77:1108-18. doi:10.1158/0008-5472.CAN-16-0797. PMID:28122327
    • (2017) Cancer Res , vol.77 , pp. 1108-1118
    • Mahne, A.E.1    Mauze, S.2    Joyce-Shaikh, B.3    Xia, J.4    Bowman, E.P.5    Beebe, A.M.6    Cua, D.J.7    Jain, R.8
  • 137
    • 84904038862 scopus 로고    scopus 로고
    • OX40 engagement depletes intratumoral Tregs via activating FcgammaRs, leading to antitumor efficacy
    • 24732076,. PMID
    • Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS, Brogdon JL. OX40 engagement depletes intratumoral Tregs via activating FcgammaRs, leading to antitumor efficacy. Immunol Cell Biol. 2014;92:475-80. doi:10.1038/icb.2014.26. PMID:24732076
    • (2014) Immunol Cell Biol , vol.92 , pp. 475-480
    • Bulliard, Y.1    Jolicoeur, R.2    Zhang, J.3    Dranoff, G.4    Wilson, N.S.5    Brogdon, J.L.6
  • 138
    • 84884229186 scopus 로고    scopus 로고
    • Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
    • 23897982,. PMID
    • Bulliard Y, Jolicoeur R, Windman M, Rue SM, Ettenberg S, Knee DA, Wilson NS, Dranoff G, Brogdon JL. Activating Fc gamma receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med. 2013;210:1685-93. doi:10.1084/jem.20130573. PMID:23897982
    • (2013) J Exp Med , vol.210 , pp. 1685-1693
    • Bulliard, Y.1    Jolicoeur, R.2    Windman, M.3    Rue, S.M.4    Ettenberg, S.5    Knee, D.A.6    Wilson, N.S.7    Dranoff, G.8    Brogdon, J.L.9
  • 139
    • 78651466506 scopus 로고    scopus 로고
    • An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells
    • 21251615, et al.,. PMID
    • Wilson NS, Yang B, Yang A, Loeser S, Marsters S, Lawrence D, Li Y, Pitti R, Totpal K, Yee S, et al. An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell. 2011;19:101-13. doi:10.1016/j.ccr.2010.11.012. PMID:21251615
    • (2011) Cancer Cell , vol.19 , pp. 101-113
    • Wilson, N.S.1    Yang, B.2    Yang, A.3    Loeser, S.4    Marsters, S.5    Lawrence, D.6    Li, Y.7    Pitti, R.8    Totpal, K.9    Yee, S.10
  • 140
    • 77958059390 scopus 로고    scopus 로고
    • Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells
    • 20842060,. PMID
    • Roberts DJ, Franklin NA, Kingeter LM, Yagita H, Tutt AL, Glennie MJ, Bullock TN. Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression of tumor infiltrating CD8(+) T cells. J Immunother. 2010;33:769-79. doi:10.1097/CJI.0b013e3181ee238f. PMID:20842060
    • (2010) J Immunother , vol.33 , pp. 769-779
    • Roberts, D.J.1    Franklin, N.A.2    Kingeter, L.M.3    Yagita, H.4    Tutt, A.L.5    Glennie, M.J.6    Bullock, T.N.7
  • 142
    • 0036195860 scopus 로고    scopus 로고
    • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    • 11877473,. PMID
    • Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest. 2002;109:651-9. doi:10.1172/JCI0214184. PMID:11877473
    • (2002) J Clin Invest , vol.109 , pp. 651-659
    • Wilcox, R.A.1    Flies, D.B.2    Zhu, G.3    Johnson, A.J.4    Tamada, K.5    Chapoval, A.I.6    Strome, S.E.7    Pease, L.R.8    Chen, L.9
  • 143
    • 85021095764 scopus 로고    scopus 로고
    • GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory
    • 28649380,. PMID
    • Durham NM, Holoweckyj N, MacGill RS, McGlinchey K, Leow CC, Robbins SH. GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory. J Immunother Cancer. 2017;5:47. doi:10.1186/s40425-017-0247-0. PMID:28649380
    • (2017) J Immunother Cancer , vol.5 , pp. 47
    • Durham, N.M.1    Holoweckyj, N.2    MacGill, R.S.3    McGlinchey, K.4    Leow, C.C.5    Robbins, S.H.6
  • 144
    • 84964402230 scopus 로고    scopus 로고
    • Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS
    • 27467927,. PMID
    • Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, Gismondi A, Santoni A, Nistico P. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203. doi:10.1080/2162402X.2015.1114203. PMID:27467927
    • (2016) Oncoimmunology , vol.5 , pp. 1114203
    • Franzese, O.1    Palermo, B.2    Di Donna, C.3    Sperduti, I.4    Ferraresi, V.5    Stabile, H.6    Gismondi, A.7    Santoni, A.8    Nistico, P.9
  • 145
    • 84976439348 scopus 로고    scopus 로고
    • Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma
    • 27622011,. PMID
    • Homet Moreno B, Mok S, Comin-Anduix B, Hu-Lieskovan S, Ribas A. Combined treatment with dabrafenib and trametinib with immune-stimulating antibodies for BRAF mutant melanoma. Oncoimmunology. 2016;5:e1052212. doi:10.1080/2162402X.2015.1052212. PMID:27622011
    • (2016) Oncoimmunology , vol.5 , pp. 1052212
    • Homet Moreno, B.1    Mok, S.2    Comin-Anduix, B.3    Hu-Lieskovan, S.4    Ribas, A.5
  • 146
  • 147
    • 84944453397 scopus 로고    scopus 로고
    • Kick-starting the cancer-immunity cycle by targeting CD40
    • 26140231,. PMID
    • Ellmark P, Mangsbo SM, Furebring C, Totterman TH, Norlen P. Kick-starting the cancer-immunity cycle by targeting CD40. Oncoimmunology. 2015;4:e1011484. doi:10.1080/2162402X.2015.1011484. PMID:26140231
    • (2015) Oncoimmunology , vol.4 , pp. 1011484
    • Ellmark, P.1    Mangsbo, S.M.2    Furebring, C.3    Totterman, T.H.4    Norlen, P.5
  • 149
    • 77958167235 scopus 로고    scopus 로고
    • Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
    • 20616215, et al.,. PMID
    • Horton HM, Bernett MJ, Peipp M, Pong E, Karki S, Chu SY, Richards JO, Chen H, Repp R, Desjarlais JR, et al. Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies. Blood. 2010;116:3004-12. doi:10.1182/blood-2010-01-265280. PMID:20616215
    • (2010) Blood , vol.116 , pp. 3004-3012
    • Horton, H.M.1    Bernett, M.J.2    Peipp, M.3    Pong, E.4    Karki, S.5    Chu, S.Y.6    Richards, J.O.7    Chen, H.8    Repp, R.9    Desjarlais, J.R.10
  • 150
    • 84976493966 scopus 로고    scopus 로고
    • Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcgammaR Engagement
    • 27265505,. PMID
    • Dahan R, Barnhart BC, Li F, Yamniuk AP, Korman AJ, Ravetch JV. Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcgammaR Engagement. Cancer Cell. 2016;29:820-31. doi:10.1016/j.ccell.2016.05.001. PMID:27265505
    • (2016) Cancer Cell , vol.29 , pp. 820-831
    • Dahan, R.1    Barnhart, B.C.2    Li, F.3    Yamniuk, A.P.4    Korman, A.J.5    Ravetch, J.V.6
  • 151
    • 80051885494 scopus 로고    scopus 로고
    • Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies
    • 21852502,. PMID
    • Li F, Ravetch JV. Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science. 2011;333:1030-4. doi:10.1126/science.1206954. PMID:21852502
    • (2011) Science , vol.333 , pp. 1030-1034
    • Li, F.1    Ravetch, J.V.2
  • 152
    • 84983781360 scopus 로고    scopus 로고
    • Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity
    • 27757306,. PMID
    • Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA. Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity. Oncoimmunology. 2016;5:e1211221. doi:10.1080/2162402X.2016.1211221. PMID:27757306
    • (2016) Oncoimmunology , vol.5 , pp. 1211221
    • Dubrovsky, L.1    Brea, E.J.2    Pankov, D.3    Casey, E.4    Dao, T.5    Liu, C.6    Scheinberg, D.A.7
  • 153
    • 84888357068 scopus 로고    scopus 로고
    • Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo
    • 24218606,. PMID
    • Li F, Ravetch JV. Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. Proc Natl Acad Sci U S A. 2013;110:19501-6. doi:10.1073/pnas.1319502110. PMID:24218606
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 19501-19506
    • Li, F.1    Ravetch, J.V.2
  • 154
    • 84994107345 scopus 로고    scopus 로고
    • Neuroblastoma patients with high-affinity FCGR2A, -3A and stimulatory KIR 2DS2 treated by long-term infusion of anti-GD2 antibody ch14.18/CHO show higher ADCC levels and improved event-free survival
    • 27999754,. PMID
    • Siebert N, Jensen C, Troschke-Meurer S, Zumpe M, Juttner M, Ehlert K, Kietz S, Muller I, Lode HN. Neuroblastoma patients with high-affinity FCGR2A, -3A and stimulatory KIR 2DS2 treated by long-term infusion of anti-GD2 antibody ch14.18/CHO show higher ADCC levels and improved event-free survival. Oncoimmunology. 2016;5:e1235108. doi:10.1080/2162402X.2016.1235108. PMID:27999754
    • (2016) Oncoimmunology , vol.5 , pp. 1235108
    • Siebert, N.1    Jensen, C.2    Troschke-Meurer, S.3    Zumpe, M.4    Juttner, M.5    Ehlert, K.6    Kietz, S.7    Muller, I.8    Lode, H.N.9
  • 155
    • 84961938333 scopus 로고    scopus 로고
    • Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions
    • 26138698,. PMID
    • DiLillo DJ, Ravetch JV. Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions. Cancer Immunol Res. 2015;3:704-13. doi:10.1158/2326-6066.CIR-15-0120. PMID:26138698
    • (2015) Cancer Immunol Res , vol.3 , pp. 704-713
    • DiLillo, D.J.1    Ravetch, J.V.2
  • 156
    • 84922189761 scopus 로고    scopus 로고
    • Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies
    • 25500122, et al.,. PMID
    • White AL, Chan HT, French RR, Willoughby J, Mockridge CI, Roghanian A, Penfold CA, Booth SG, Dodhy A, Polak ME, et al. Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies. Cancer Cell. 2015;27:138-48. doi:10.1016/j.ccell.2014.11.001. PMID:25500122
    • (2015) Cancer Cell , vol.27 , pp. 138-148
    • White, A.L.1    Chan, H.T.2    French, R.R.3    Willoughby, J.4    Mockridge, C.I.5    Roghanian, A.6    Penfold, C.A.7    Booth, S.G.8    Dodhy, A.9    Polak, M.E.10
  • 159
    • 84905992571 scopus 로고    scopus 로고
    • Fcgamma receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization
    • 25024386, et al.,. PMID
    • White AL, Dou L, Chan HT, Field VL, Mockridge CI, Moss K, Williams EL, Booth SG, French RR, Potter EA, et al. Fcgamma receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization. J Immunol. 2014;193:1828-35. doi:10.4049/jimmunol.1303204. PMID:25024386
    • (2014) J Immunol , vol.193 , pp. 1828-1835
    • White, A.L.1    Dou, L.2    Chan, H.T.3    Field, V.L.4    Mockridge, C.I.5    Moss, K.6    Williams, E.L.7    Booth, S.G.8    French, R.R.9    Potter, E.A.10
  • 160
    • 33645971964 scopus 로고    scopus 로고
    • Clinical medicine. Accident prompts a closer look at antibody trials
    • Marshall E. Clinical medicine. Accident prompts a closer look at antibody trials. Science. 2006;312:172.
    • (2006) Science , vol.312 , pp. 172
    • Marshall, E.1
  • 161
    • 84860257860 scopus 로고    scopus 로고
    • The storm has cleared: lessons from the CD28 superagonist TGN1412 trial
    • 22487653,. PMID
    • Hunig T. The storm has cleared: lessons from the CD28 superagonist TGN1412 trial. Nat Rev Immunol. 2012;12:317-8. doi:10.1038/nri3192-c2. PMID:22487653
    • (2012) Nat Rev Immunol , vol.12 , pp. 317-318
    • Hunig, T.1
  • 162
    • 33744991740 scopus 로고    scopus 로고
    • TGN1412: scrutinizing preclinical trials of antibody-based medicines
    • 16710395,. PMID
    • Hansen S, Leslie RG. TGN1412: scrutinizing preclinical trials of antibody-based medicines. Nature. 2006;441:282. doi:10.1038/441282a. PMID:16710395
    • (2006) Nature , vol.441 , pp. 282
    • Hansen, S.1    Leslie, R.G.2
  • 163
    • 33646555791 scopus 로고    scopus 로고
    • TGN1412–a regulator's perspective
    • 16680120,. PMID
    • Schneider CK, Kalinke U, Lower J. TGN1412–a regulator's perspective. Nat Biotechnol. 2006;24:493-6. doi:10.1038/nbt0506-493. PMID:16680120
    • (2006) Nat Biotechnol , vol.24 , pp. 493-496
    • Schneider, C.K.1    Kalinke, U.2    Lower, J.3
  • 164
    • 33646379402 scopus 로고    scopus 로고
    • Injury to research volunteers–the clinical-research nightmare
    • 16672696,. PMID
    • Wood AJ, Darbyshire J. Injury to research volunteers–the clinical-research nightmare. N Engl J Med. 2006;354:1869-71. doi:10.1056/NEJMp068082. PMID:16672696
    • (2006) N Engl J Med , vol.354 , pp. 1869-1871
    • Wood, A.J.1    Darbyshire, J.2
  • 165
    • 84988028167 scopus 로고    scopus 로고
    • The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account
    • 27191544,. PMID
    • Hunig T. The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account. Febs j. 2016;283:3325-34. doi:10.1111/febs.13754. PMID:27191544
    • (2016) Febs j , vol.283 , pp. 3325-3334
    • Hunig, T.1
  • 166
    • 84984801011 scopus 로고    scopus 로고
    • From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis
    • 27586803,. PMID
    • Tyrsin D, Chuvpilo S, Matskevich A, Nemenov D, Romer PS, Tabares P, Hunig T. From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2016;34:45-8. PMID:27586803
    • (2016) Clin Exp Rheumatol , vol.34 , pp. 45-48
    • Tyrsin, D.1    Chuvpilo, S.2    Matskevich, A.3    Nemenov, D.4    Romer, P.S.5    Tabares, P.6    Hunig, T.7
  • 167
    • 84949532906 scopus 로고    scopus 로고
    • Experimental drug that injured UK volunteers resumes in human trials
    • 25838401,. PMID
    • Dyer O. Experimental drug that injured UK volunteers resumes in human trials. Bmj. 2015;350:h1831. doi:10.1136/bmj.h1831. PMID:25838401
    • (2015) Bmj , vol.350 , pp. h1831
    • Dyer, O.1
  • 170
    • 84938356701 scopus 로고    scopus 로고
    • Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment
    • 25623164,. PMID
    • Zippelius A, Schreiner J, Herzig P, Muller P. Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment. Cancer Immunol Res. 2015;3:236-44. doi:10.1158/2326-6066.CIR-14-0226. PMID:25623164
    • (2015) Cancer Immunol Res , vol.3 , pp. 236-244
    • Zippelius, A.1    Schreiner, J.2    Herzig, P.3    Muller, P.4
  • 171
    • 84995693608 scopus 로고    scopus 로고
    • Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor
    • 27634762,. PMID
    • Ngiow SF, Young A, Blake SJ, Hill GR, Yagita H, Teng MW, Korman AJ, Smyth MJ. Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor. Cancer Res. 2016;76:6266-77. doi:10.1158/0008-5472.CAN-16-2141. PMID:27634762
    • (2016) Cancer Res , vol.76 , pp. 6266-6277
    • Ngiow, S.F.1    Young, A.2    Blake, S.J.3    Hill, G.R.4    Yagita, H.5    Teng, M.W.6    Korman, A.J.7    Smyth, M.J.8
  • 172
    • 84919632874 scopus 로고    scopus 로고
    • OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence
    • 25404365, et al.,. PMID
    • Buchan S, Manzo T, Flutter B, Rogel A, Edwards N, Zhang L, Sivakumaran S, Ghorashian S, Carpenter B, Bennett C, et al. OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence. J Immunol. 2015;194:125-33. doi:10.4049/jimmunol.1401644. PMID:25404365
    • (2015) J Immunol , vol.194 , pp. 125-133
    • Buchan, S.1    Manzo, T.2    Flutter, B.3    Rogel, A.4    Edwards, N.5    Zhang, L.6    Sivakumaran, S.7    Ghorashian, S.8    Carpenter, B.9    Bennett, C.10
  • 174
    • 85016119137 scopus 로고    scopus 로고
    • Therapeutic Efficacy of 4-1BB Costimulation Is Abrogated by PD-1 Blockade in a Model of Spontaneous B-cell Lymphoma
    • 28115358,. PMID
    • McKee SJ, Doff BL, Soon MS, Mattarollo SR. Therapeutic Efficacy of 4-1BB Costimulation Is Abrogated by PD-1 Blockade in a Model of Spontaneous B-cell Lymphoma. Cancer Immunol Res. 2017;5:191-7. doi:10.1158/2326-6066.CIR-16-0249. PMID:28115358
    • (2017) Cancer Immunol Res , vol.5 , pp. 191-197
    • McKee, S.J.1    Doff, B.L.2    Soon, M.S.3    Mattarollo, S.R.4
  • 175
    • 85017108448 scopus 로고    scopus 로고
    • Targeted agents and immunotherapies: optimizing outcomes in melanoma
    • 28374786,. PMID
    • Luke JJ, Flaherty KT, Ribas A, Long GV. Targeted agents and immunotherapies: optimizing outcomes in melanoma. Nat Rev Clin Oncol. 2017;14:463-82. doi:10.1038/nrclinonc.2017.43. PMID:28374786
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 463-482
    • Luke, J.J.1    Flaherty, K.T.2    Ribas, A.3    Long, G.V.4
  • 176
    • 84959060166 scopus 로고    scopus 로고
    • Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?
    • 26855028,. PMID
    • Ryan JM, Wasser JS, Adler AJ, Vella AT. Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Expert Opin Biol Ther. 2016;16:655-74. doi:10.1517/14712598.2016.1152256. PMID:26855028
    • (2016) Expert Opin Biol Ther , vol.16 , pp. 655-674
    • Ryan, J.M.1    Wasser, J.S.2    Adler, A.J.3    Vella, A.T.4
  • 178
    • 84929469144 scopus 로고    scopus 로고
    • Immunomodulatory antibody therapy of cancer: the closer, the better
    • 25351746,. PMID
    • Dronca RS, Dong H. Immunomodulatory antibody therapy of cancer: the closer, the better. Clin Cancer Res. 2015;21:944-6. doi:10.1158/1078-0432.CCR-14-2111. PMID:25351746
    • (2015) Clin Cancer Res , vol.21 , pp. 944-946
    • Dronca, R.S.1    Dong, H.2
  • 179
    • 84944474622 scopus 로고    scopus 로고
    • Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma
    • 26155388,. PMID
    • Combe P, de Guillebon E, Thibault C, Granier C, Tartour E, Oudard S. Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma. Oncoimmunology. 2015;4:e1001236. doi:10.1080/2162402X.2014.1001236. PMID:26155388
    • (2015) Oncoimmunology , vol.4 , pp. 1001236
    • Combe, P.1    de Guillebon, E.2    Thibault, C.3    Granier, C.4    Tartour, E.5    Oudard, S.6
  • 180
    • 84921518859 scopus 로고    scopus 로고
    • Dendritic cell-targeted vaccines–hope or hype?
    • 25190285,. PMID
    • Kastenmuller W, Kastenmuller K, Kurts C, Seder RA. Dendritic cell-targeted vaccines–hope or hype? Nat Rev Immunol. 2014;14:705-11. doi:10.1038/nri3727. PMID:25190285
    • (2014) Nat Rev Immunol , vol.14 , pp. 705-711
    • Kastenmuller, W.1    Kastenmuller, K.2    Kurts, C.3    Seder, R.A.4
  • 182
    • 84989271235 scopus 로고    scopus 로고
    • The cancer vaccine resurgence
    • 27681782,. PMID
    • Mullard A. The cancer vaccine resurgence. Nat Rev Drug Discov. 2016;15:663-5. doi:10.1038/nrd.2016.201. PMID:27681782
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 663-665
    • Mullard, A.1
  • 183
    • 84960372950 scopus 로고    scopus 로고
    • Vaccines for established cancer: overcoming the challenges posed by immune evasion
    • 26965076,. PMID
    • van der Burg SH, Arens R, Ossendorp F, van Hall T, Melief CJ. Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nat Rev Cancer. 2016;16:219-33. doi:10.1038/nrc.2016.16. PMID:26965076
    • (2016) Nat Rev Cancer , vol.16 , pp. 219-233
    • van der Burg, S.H.1    Arens, R.2    Ossendorp, F.3    van Hall, T.4    Melief, C.J.5
  • 185
    • 34548180389 scopus 로고    scopus 로고
    • Heat-shock protein-peptide complex-96 for the treatment of cancer
    • 17696824,. PMID
    • Amato RJ. Heat-shock protein-peptide complex-96 for the treatment of cancer. Expert Opin Biol Ther. 2007;7:1267-73. doi:10.1517/14712598.7.8.1267. PMID:17696824
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 1267-1273
    • Amato, R.J.1
  • 186
    • 79960406242 scopus 로고    scopus 로고
    • Human tumor cells killed by anthracyclines induce a tumor-specific immune response
    • 21602432,. PMID
    • Fucikova J, Kralikova P, Fialova A, Brtnicky T, Rob L, Bartunkova J, Spisek R. Human tumor cells killed by anthracyclines induce a tumor-specific immune response. Cancer Res. 2011;71:4821-33. doi:10.1158/0008-5472.CAN-11-0950. PMID:21602432
    • (2011) Cancer Res , vol.71 , pp. 4821-4833
    • Fucikova, J.1    Kralikova, P.2    Fialova, A.3    Brtnicky, T.4    Rob, L.5    Bartunkova, J.6    Spisek, R.7
  • 187
    • 34249650184 scopus 로고    scopus 로고
    • Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications
    • 17299090,. PMID
    • Spisek R, Charalambous A, Mazumder A, Vesole DH, Jagannath S, Dhodapkar MV. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood. 2007;109:4839-45. doi:10.1182/blood-2006-10-054221. PMID:17299090
    • (2007) Blood , vol.109 , pp. 4839-4845
    • Spisek, R.1    Charalambous, A.2    Mazumder, A.3    Vesole, D.H.4    Jagannath, S.5    Dhodapkar, M.V.6
  • 188
    • 34548271716 scopus 로고    scopus 로고
    • Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells
    • 17721082,. PMID
    • Spisek R, Dhodapkar MV. Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells. Cell Cycle. 2007;6:1962-5. doi:10.4161/cc.6.16.4601. PMID:17721082
    • (2007) Cell Cycle , vol.6 , pp. 1962-1965
    • Spisek, R.1    Dhodapkar, M.V.2
  • 189
    • 84978196961 scopus 로고    scopus 로고
    • GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development
    • 26916005,. PMID
    • Wu BX, Hong F, Zhang Y, Ansa-Addo E, Li Z. GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development. Adv Cancer Res. 2016;129:165-90. doi:10.1016/bs.acr.2015.09.001. PMID:26916005
    • (2016) Adv Cancer Res , vol.129 , pp. 165-190
    • Wu, B.X.1    Hong, F.2    Zhang, Y.3    Ansa-Addo, E.4    Li, Z.5
  • 190
    • 85016040815 scopus 로고    scopus 로고
    • Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination
    • 27364122,. PMID
    • Fromm G, de Silva S, Giffin L, Xu X, Rose J, Schreiber TH. Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination. Cancer Immunol Res. 2016;4:766-78. doi:10.1158/2326-6066.CIR-15-0228. PMID:27364122
    • (2016) Cancer Immunol Res , vol.4 , pp. 766-778
    • Fromm, G.1    de Silva, S.2    Giffin, L.3    Xu, X.4    Rose, J.5    Schreiber, T.H.6
  • 191
    • 85019607829 scopus 로고    scopus 로고
    • Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist alpha-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity
    • 28680744,. PMID
    • Liu Z, Hao X, Zhang Y, Zhang J, Carey CD, Falo LD, Jr., Storkus WJ, You Z. Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist alpha-GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity. Oncoimmunology. 2017;6:e1315487. doi:10.1080/2162402X.2017.1315487. PMID:28680744
    • (2017) Oncoimmunology , vol.6 , pp. 1315487
    • Liu, Z.1    Hao, X.2    Zhang, Y.3    Zhang, J.4    Carey, C.D.5    Falo, L.D.6    Storkus, W.J.7    You, Z.8
  • 192
    • 84954515793 scopus 로고    scopus 로고
    • Reducing toxicity of 4-1BB costimulation: targeting 4-1BB ligands to the tumor stroma with bi-specific aptamer conjugates
    • 25949891,. PMID
    • Schrand B, Berezhnoy A, Brenneman R, Williams A, Levay A, Gilboa E. Reducing toxicity of 4-1BB costimulation: targeting 4-1BB ligands to the tumor stroma with bi-specific aptamer conjugates. Oncoimmunology. 2015;4:e970918. doi:10.4161/21624011.2014.970918. PMID:25949891
    • (2015) Oncoimmunology , vol.4 , pp. 970918
    • Schrand, B.1    Berezhnoy, A.2    Brenneman, R.3    Williams, A.4    Levay, A.5    Gilboa, E.6
  • 193
    • 84954412874 scopus 로고    scopus 로고
    • Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors
    • 26942084,. PMID
    • Yelamos J, Galindo M, Navarro J, Albanell J, Rovira A, Rojo F, Oliver J. Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors. Oncoimmunology. 2016;5:e1065370. doi:10.1080/2162402X.2015.1065370. PMID:26942084
    • (2016) Oncoimmunology , vol.5 , pp. 1065370
    • Yelamos, J.1    Galindo, M.2    Navarro, J.3    Albanell, J.4    Rovira, A.5    Rojo, F.6    Oliver, J.7
  • 194
    • 84979698228 scopus 로고    scopus 로고
    • Mechanisms and regulation of endothelial VEGF receptor signalling
    • 27461391,. PMID
    • Simons M, Gordon E, Claesson-Welsh L. Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol. 2016;17:611-25. doi:10.1038/nrm.2016.87. PMID:27461391
    • (2016) Nat Rev Mol Cell Biol , vol.17 , pp. 611-625
    • Simons, M.1    Gordon, E.2    Claesson-Welsh, L.3
  • 195
    • 84954569855 scopus 로고    scopus 로고
    • Ten years of anti-vascular endothelial growth factor therapy
    • 26775688,. PMID
    • Ferrara N, Adamis AP. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016;15:385-403. doi:10.1038/nrd.2015.17. PMID:26775688
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 385-403
    • Ferrara, N.1    Adamis, A.P.2
  • 196
    • 84933050304 scopus 로고    scopus 로고
    • The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
    • 26105538,. PMID
    • Barker HE, Paget JT, Khan AA, Harrington KJ. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer. 2015;15:409-25. doi:10.1038/nrc3958. PMID:26105538
    • (2015) Nat Rev Cancer , vol.15 , pp. 409-425
    • Barker, H.E.1    Paget, J.T.2    Khan, A.A.3    Harrington, K.J.4
  • 198
    • 84997497897 scopus 로고    scopus 로고
    • Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking?
    • 27190630,. PMID
    • Demaria S, Formenti SC. Can abscopal effects of local radiotherapy be predicted by modeling T cell trafficking? J Immunother Cancer. 2016;4:29. doi:10.1186/s40425-016-0133-1. PMID:27190630
    • (2016) J Immunother Cancer , vol.4 , pp. 29
    • Demaria, S.1    Formenti, S.C.2
  • 199
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
    • 26095785, et al.,. PMID
    • Golden EB, Chhabra A, Chachoua A, Adams S, Donach M, Fenton-Kerimian M, Friedman K, Ponzo F, Babb JS, Goldberg J, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol. 2015;16:795-803. PMID:26095785
    • (2015) Lancet Oncol , vol.16 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3    Adams, S.4    Donach, M.5    Fenton-Kerimian, M.6    Friedman, K.7    Ponzo, F.8    Babb, J.S.9    Goldberg, J.10
  • 200
    • 84919475564 scopus 로고    scopus 로고
    • Combination of radiotherapy and immune checkpoint inhibitors
    • 25481263,. PMID
    • Pilones KA, Vanpouille-Box C, Demaria S. Combination of radiotherapy and immune checkpoint inhibitors. Semin Radiat Oncol. 2015;25:28-33. PMID:25481263
    • (2015) Semin Radiat Oncol , vol.25 , pp. 28-33
    • Pilones, K.A.1    Vanpouille-Box, C.2    Demaria, S.3
  • 204
    • 85027297483 scopus 로고    scopus 로고
    • Abstract CT023: Phase I results from the combination of an immune-activating anti-CD27 antibody (varlilumab) in combination with PD-1 blockade (nivolumab): activation across multiple immune pathways without untoward immune-related adverse events
    • et al
    • Sanborn RE, Pishvain MJ, Callahan MK, Rizvi N, Kluger H, Yellin M, Rawls T, Vitale L, Halim A, Davis T, et al. Abstract CT023: Phase I results from the combination of an immune-activating anti-CD27 antibody (varlilumab) in combination with PD-1 blockade (nivolumab): activation across multiple immune pathways without untoward immune-related adverse events. Cancer Research. 2016;76:CT023.
    • (2016) Cancer Research , vol.76 , pp. CT023
    • Sanborn, R.E.1    Pishvain, M.J.2    Callahan, M.K.3    Rizvi, N.4    Kluger, H.5    Yellin, M.6    Rawls, T.7    Vitale, L.8    Halim, A.9    Davis, T.10
  • 205
    • 84946068678 scopus 로고    scopus 로고
    • Dacetuzumab plus rituximab, ifosfamide, carboplatin and etoposide as salvage therapy for patients with diffuse large B-cell lymphoma relapsing after rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone: a randomized, double-blind, placebo-controlled phase 2b trial
    • 25651427, et al.,. PMID
    • Fayad L, Ansell SM, Advani R, Coiffier B, Stuart R, Bartlett NL, Forero-Torres A, Kuliczkowski K, Belada D, Ng E, et al. Dacetuzumab plus rituximab, ifosfamide, carboplatin and etoposide as salvage therapy for patients with diffuse large B-cell lymphoma relapsing after rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone: a randomized, double-blind, placebo-controlled phase 2b trial. Leuk Lymphoma. 2015;56:2569-78. PMID:25651427
    • (2015) Leuk Lymphoma , vol.56 , pp. 2569-2578
    • Fayad, L.1    Ansell, S.M.2    Advani, R.3    Coiffier, B.4    Stuart, R.5    Bartlett, N.L.6    Forero-Torres, A.7    Kuliczkowski, K.8    Belada, D.9    Ng, E.10
  • 206
    • 84949936992 scopus 로고    scopus 로고
    • A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma
    • 26386124, et al.,. PMID
    • Nowak AK, Cook AM, McDonnell AM, Millward MJ, Creaney J, Francis RJ, Hasani A, Segal A, Musk AW, Turlach BA, et al. A phase 1b clinical trial of the CD40-activating antibody CP-870,893 in combination with cisplatin and pemetrexed in malignant pleural mesothelioma. Ann Oncol. 2015;26:2483-90. PMID:26386124
    • (2015) Ann Oncol , vol.26 , pp. 2483-2490
    • Nowak, A.K.1    Cook, A.M.2    McDonnell, A.M.3    Millward, M.J.4    Creaney, J.5    Francis, R.J.6    Hasani, A.7    Segal, A.8    Musk, A.W.9    Turlach, B.A.10
  • 208
    • 84927615313 scopus 로고    scopus 로고
    • Clinical and biological effects of an agonist anti-CD40 antibody: a Cancer Research UK phase I study
    • 25589626, et al.,. PMID
    • Johnson P, Challis R, Chowdhury F, Gao Y, Harvey M, Geldart T, Kerr P, Chan C, Smith A, Steven N, et al. Clinical and biological effects of an agonist anti-CD40 antibody: a Cancer Research UK phase I study. Clin Cancer Res. 2015;21:1321-8. doi:10.1158/1078-0432.CCR-14-2355. PMID:25589626
    • (2015) Clin Cancer Res , vol.21 , pp. 1321-1328
    • Johnson, P.1    Challis, R.2    Chowdhury, F.3    Gao, Y.4    Harvey, M.5    Geldart, T.6    Kerr, P.7    Chan, C.8    Smith, A.9    Steven, N.10
  • 210
    • 85029504106 scopus 로고    scopus 로고
    • Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors
    • Tolcher AW, Sznol M, Hu-Lieskovan S, Papadopoulos KP, Patnaik A, Rasco D, Di Gravio D, Huang B, Gambhire D, Chen Y, et al. Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017;in press. doi:10.1158/1078-0432.CCR-17-1243. PMID:28634283
    • (2017) Clin Cancer Res
    • Tolcher, A.W.1    Sznol, M.2    Hu-Lieskovan, S.3    Papadopoulos, K.P.4    Patnaik, A.5    Rasco, D.6    Di Gravio, D.7    Huang, B.8    Gambhire, D.9    Chen, Y.10
  • 212
    • 85036497908 scopus 로고    scopus 로고
    • Dose escalation results from a first-in-human, phase 1 study of the glucocorticoid-induced TNF receptor-related protein (GITR) agonist AMG 228 in patients (Pts) with advanced solid tumors
    • Tran B, Carvajal RD, Marabelle A, Patel SP, LoRusso P, Rasmussen E, Juan G, Upreti VV, Ngarmchamnanrith G, Schöffski P. Dose escalation results from a first-in-human, phase 1 study of the glucocorticoid-induced TNF receptor-related protein (GITR) agonist AMG 228 in patients (Pts) with advanced solid tumors. J Clin Oncol. 2017;35:2521.
    • (2017) J Clin Oncol , vol.35 , pp. 2521
    • Tran, B.1    Carvajal, R.D.2    Marabelle, A.3    Patel, S.P.4    LoRusso, P.5    Rasmussen, E.6    Juan, G.7    Upreti, V.V.8    Ngarmchamnanrith, G.9    Schöffski, P.10
  • 213
    • 84991236330 scopus 로고    scopus 로고
    • First-in-human phase 1 single-dose study of TRX-518, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody in adults with advanced solid tumors
    • Koon HB, Shepard DR, Merghoub T, Schaer DA, Sirard CA, Wolchok JD. First-in-human phase 1 single-dose study of TRX-518, an anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) monoclonal antibody in adults with advanced solid tumors. Journal of Clinical Oncology. 2016;34:3017.
    • (2016) Journal of Clinical Oncology , vol.34 , pp. 3017
    • Koon, H.B.1    Shepard, D.R.2    Merghoub, T.3    Schaer, D.A.4    Sirard, C.A.5    Wolchok, J.D.6
  • 214
    • 85027193113 scopus 로고    scopus 로고
    • Preliminary results of a phase I/IIa study of BMS-986156 (glucocorticoid-induced tumor necrosis factor receptor–related gene [GITR] agonist), alone and in combination with nivolumab in pts with advanced solid tumors
    • et al
    • Siu LL, Steeghs N, Meniawy T, Joerger M, Spratlin JL, Rottey S, Nagrial A, Cooper A, Meier R, Guan X, et al. Preliminary results of a phase I/IIa study of BMS-986156 (glucocorticoid-induced tumor necrosis factor receptor–related gene [GITR] agonist), alone and in combination with nivolumab in pts with advanced solid tumors. Journal of Clinical Oncology. 2017;35:104.
    • (2017) Journal of Clinical Oncology , vol.35 , pp. 104
    • Siu, L.L.1    Steeghs, N.2    Meniawy, T.3    Joerger, M.4    Spratlin, J.L.5    Rottey, S.6    Nagrial, A.7    Cooper, A.8    Meier, R.9    Guan, X.10
  • 216
    • 85036598136 scopus 로고    scopus 로고
    • The relationship of pharmacodynamics (PD) and pharmacokinetics (PK) to clinical outcomes in a phase I study of OX40 agonistic monoclonal antibody (mAb) PF-04518600 (PF-8600)
    • et al
    • El-Khoueiry AB, Hamid O, Thompson JA, Ros W, Eskens F, Doi T, Hu-Lieskovan S, Chou J, Liao K, Ganguly BJ, et al. The relationship of pharmacodynamics (PD) and pharmacokinetics (PK) to clinical outcomes in a phase I study of OX40 agonistic monoclonal antibody (mAb) PF-04518600 (PF-8600). Journal of Clinical Oncology. 2017;35:3027.
    • (2017) Journal of Clinical Oncology , vol.35 , pp. 3027
    • El-Khoueiry, A.B.1    Hamid, O.2    Thompson, J.A.3    Ros, W.4    Eskens, F.5    Doi, T.6    Hu-Lieskovan, S.7    Chou, J.8    Liao, K.9    Ganguly, B.J.10
  • 218
  • 219
    • 84966771330 scopus 로고    scopus 로고
    • Targeting T Cell Co-receptors for Cancer Therapy
    • 27192570,. PMID
    • Callahan MK, Postow MA, Wolchok JD. Targeting T Cell Co-receptors for Cancer Therapy. Immunity. 2016;44:1069-78. doi:10.1016/j.immuni.2016.04.023. PMID:27192570
    • (2016) Immunity , vol.44 , pp. 1069-1078
    • Callahan, M.K.1    Postow, M.A.2    Wolchok, J.D.3
  • 220
    • 85016724516 scopus 로고    scopus 로고
    • Cancer immunotherapies targeting the PD-1 signaling pathway
    • 28376884,. PMID
    • Iwai Y, Hamanishi J, Chamoto K, Honjo T. Cancer immunotherapies targeting the PD-1 signaling pathway. J Biomed Sci. 2017;24:26. doi:10.1186/s12929-017-0329-9. PMID:28376884
    • (2017) J Biomed Sci , vol.24 , pp. 26
    • Iwai, Y.1    Hamanishi, J.2    Chamoto, K.3    Honjo, T.4
  • 221
    • 84944449557 scopus 로고    scopus 로고
    • Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma-An exclamation sign with a question mark
    • 26140249,. PMID
    • Kroemer G, Galluzzi L. Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma-An exclamation sign with a question mark. Oncoimmunology. 2015;4:e1058037. doi:10.1080/2162402X.2015.1058037. PMID:26140249
    • (2015) Oncoimmunology , vol.4 , pp. 1058037
    • Kroemer, G.1    Galluzzi, L.2
  • 222
    • 84976535754 scopus 로고    scopus 로고
    • CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma
    • 27471622,. PMID
    • Yu GT, Bu LL, Zhao YY, Mao L, Deng WW, Wu TF, Zhang WF, Sun ZJ. CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma. Oncoimmunology. 2016;5:e1151594. doi:10.1080/2162402X.2016.1151594. PMID:27471622
    • (2016) Oncoimmunology , vol.5 , pp. 1151594
    • Yu, G.T.1    Bu, L.L.2    Zhao, Y.Y.3    Mao, L.4    Deng, W.W.5    Wu, T.F.6    Zhang, W.F.7    Sun, Z.J.8
  • 225
    • 84978499806 scopus 로고    scopus 로고
    • Chemotherapy and immunotherapy: A close interplay to fight cancer?
    • 27622046,. PMID
    • Hanoteau A, Moser M. Chemotherapy and immunotherapy: A close interplay to fight cancer? Oncoimmunology. 2016;5:e1190061. doi:10.1080/2162402X.2016.1190061. PMID:27622046
    • (2016) Oncoimmunology , vol.5 , pp. 1190061
    • Hanoteau, A.1    Moser, M.2
  • 226
    • 85036494969 scopus 로고    scopus 로고
    • Varlilumab Is Safe and Active in Patients with Advanced Solid Tumors
    • Varlilumab Is Safe and Active in Patients with Advanced Solid Tumors. Cancer Discov. 2017;7:OF9. doi:10.1158/2159-8290.CD-RW2017-089.
    • (2017) Cancer Discov , vol.7 , pp. OF9
  • 229
    • 78549256115 scopus 로고    scopus 로고
    • Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors
    • 20855968,. PMID
    • Ruter J, Antonia SJ, Burris HA, Huhn RD, Vonderheide RH. Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors. Cancer Biol Ther. 2010;10:983-93. doi:10.4161/cbt.10.10.13251. PMID:20855968
    • (2010) Cancer Biol Ther , vol.10 , pp. 983-993
    • Ruter, J.1    Antonia, S.J.2    Burris, H.A.3    Huhn, R.D.4    Vonderheide, R.H.5
  • 231
    • 77958045597 scopus 로고    scopus 로고
    • CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893
    • 20842056, et al.,. PMID
    • Kalbasi A, Fonsatti E, Natali PG, Altomonte M, Bertocci E, Cutaia O, Calabro L, Chiou M, Tap W, Chmielowski B, et al. CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893. J Immunother. 2010;33:810-6. doi:10.1097/CJI.0b013e3181ee73a7. PMID:20842056
    • (2010) J Immunother , vol.33 , pp. 810-816
    • Kalbasi, A.1    Fonsatti, E.2    Natali, P.G.3    Altomonte, M.4    Bertocci, E.5    Cutaia, O.6    Calabro, L.7    Chiou, M.8    Tap, W.9    Chmielowski, B.10
  • 232
    • 70749083844 scopus 로고    scopus 로고
    • Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation
    • 19906293,. PMID
    • Carpenter EL, Mick R, Ruter J, Vonderheide RH. Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation. J Transl Med. 2009;7:93. doi:10.1186/1479-5876-7-93. PMID:19906293
    • (2009) J Transl Med , vol.7 , pp. 93
    • Carpenter, E.L.1    Mick, R.2    Ruter, J.3    Vonderheide, R.H.4
  • 233
    • 85014362982 scopus 로고    scopus 로고
    • Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia
    • 27913530,. PMID
    • Frey NV, Porter DL. Cytokine release syndrome with novel therapeutics for acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program. 2016; 2016:567-72. PMID:27913530
    • (2016) Hematology Am Soc Hematol Educ Program , vol.2016 , pp. 567-572
    • Frey, N.V.1    Porter, D.L.2
  • 234
    • 84897568616 scopus 로고    scopus 로고
    • Managing cytokine release syndrome associated with novel T cell-engaging therapies
    • 24667956,. PMID
    • Maude SL, Barrett D, Teachey DT, Grupp SA. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J. 2014;20:119-22. doi:10.1097/PPO.0000000000000035. PMID:24667956
    • (2014) Cancer J , vol.20 , pp. 119-122
    • Maude, S.L.1    Barrett, D.2    Teachey, D.T.3    Grupp, S.A.4
  • 235
    • 73849137192 scopus 로고    scopus 로고
    • Recent advances in the understanding of drug-mediated infusion reactions and cytokine release syndrome
    • 20047153,. PMID
    • Walker M, Makropoulos D, Achuthanandam R, Bugelski PJ. Recent advances in the understanding of drug-mediated infusion reactions and cytokine release syndrome. Curr Opin Drug Discov Devel. 2010;13:124-35. PMID:20047153
    • (2010) Curr Opin Drug Discov Devel , vol.13 , pp. 124-135
    • Walker, M.1    Makropoulos, D.2    Achuthanandam, R.3    Bugelski, P.J.4
  • 236
    • 85018509133 scopus 로고    scopus 로고
    • New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
    • 28407743,. PMID
    • Kroschinsky F, Stolzel F, von Bonin S, Beutel G, Kochanek M, Kiehl M, Schellongowski P, Intensive Care in H, Oncological Patients Collaborative G. New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management. Crit Care. 2017;21:89. doi:10.1186/s13054-017-1678-1. PMID:28407743
    • (2017) Crit Care , vol.21 , pp. 89
    • Kroschinsky, F.1    Stolzel, F.2    von Bonin, S.3    Beutel, G.4    Kochanek, M.5    Kiehl, M.6    Schellongowski, P.7
  • 238
    • 84867896903 scopus 로고    scopus 로고
    • Transcriptional control of effector and memory CD8+ T cell differentiation
    • 23080391,. PMID
    • Kaech SM, Cui W. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol. 2012;12:749-61. doi:10.1038/nri3307. PMID:23080391
    • (2012) Nat Rev Immunol , vol.12 , pp. 749-761
    • Kaech, S.M.1    Cui, W.2
  • 239
    • 84957442580 scopus 로고    scopus 로고
    • The multifaceted role of CD4(+) T cells in CD8(+) T cell memory
    • 26781939,. PMID
    • Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol. 2016;16:102-11. doi:10.1038/nri.2015.10. PMID:26781939
    • (2016) Nat Rev Immunol , vol.16 , pp. 102-111
    • Laidlaw, B.J.1    Craft, J.E.2    Kaech, S.M.3
  • 240
    • 84957442891 scopus 로고    scopus 로고
    • Regulatory T cell memory
    • 26688349,. PMID
    • Rosenblum MD, Way SS, Abbas AK. Regulatory T cell memory. Nat Rev Immunol. 2016;16:90-101. doi:10.1038/nri.2015.1. PMID:26688349
    • (2016) Nat Rev Immunol , vol.16 , pp. 90-101
    • Rosenblum, M.D.1    Way, S.S.2    Abbas, A.K.3
  • 241
    • 84997831536 scopus 로고    scopus 로고
    • Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab
    • 26500773,. PMID
    • Ramakrishna V, Sundarapandiyan K, Zhao B, Bylesjo M, Marsh HC, Keler T. Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab. J Immunother Cancer. 2015;3:37. doi:10.1186/s40425-015-0080-2. PMID:26500773
    • (2015) J Immunother Cancer , vol.3 , pp. 37
    • Ramakrishna, V.1    Sundarapandiyan, K.2    Zhao, B.3    Bylesjo, M.4    Marsh, H.C.5    Keler, T.6
  • 242
    • 85017393100 scopus 로고    scopus 로고
    • iRECIST: A clarification of tumour response assessment in the immunotherapy era
    • 28385325,. PMID
    • Ferte C, Marabelle A. iRECIST: A clarification of tumour response assessment in the immunotherapy era. Eur J Cancer. 2017;77:165-7. doi:10.1016/j.ejca.2017.02.015. PMID:28385325
    • (2017) Eur J Cancer , vol.77 , pp. 165-167
    • Ferte, C.1    Marabelle, A.2
  • 243
    • 85036552408 scopus 로고    scopus 로고
    • IrRECIST and iRECIST: the devil is in the details
    • 28383646,. PMID
    • Le Lay J, Jarraya H, Lebellec L, Penel N. IrRECIST and iRECIST: the devil is in the details. Ann Oncol. 2017. PMID:28383646
    • (2017) Ann Oncol
    • Le Lay, J.1    Jarraya, H.2    Lebellec, L.3    Penel, N.4
  • 248
    • 34447136111 scopus 로고    scopus 로고
    • A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib
    • 17616683, et al.,. PMID
    • de La Motte Rouge T, Galluzzi L, Olaussen KA, Zermati Y, Tasdemir E, Robert T, Ripoche H, Lazar V, Dessen P, Harper F, et al. A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib. Cancer Res. 2007;67:6253-62. doi:10.1158/0008-5472.CAN-07-0538. PMID:17616683
    • (2007) Cancer Res , vol.67 , pp. 6253-6262
    • de La Motte Rouge, T.1    Galluzzi, L.2    Olaussen, K.A.3    Zermati, Y.4    Tasdemir, E.5    Robert, T.6    Ripoche, H.7    Lazar, V.8    Dessen, P.9    Harper, F.10
  • 250
    • 84977071041 scopus 로고    scopus 로고
    • Cytokine responsiveness of CD8(+) T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients
    • 24883189,. PMID
    • Everson RG, Jin RM, Wang X, Safaee M, Scharnweber R, Lisiero DN, Soto H, Liau LM, Prins RM. Cytokine responsiveness of CD8(+) T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients. J Immunother Cancer. 2014;2:10. doi:10.1186/2051-1426-2-10. PMID:24883189
    • (2014) J Immunother Cancer , vol.2 , pp. 10
    • Everson, R.G.1    Jin, R.M.2    Wang, X.3    Safaee, M.4    Scharnweber, R.5    Lisiero, D.N.6    Soto, H.7    Liau, L.M.8    Prins, R.M.9
  • 251
    • 85018934527 scopus 로고    scopus 로고
    • Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma
    • 28266140, et al.,. PMID
    • Yamazaki N, Kiyohara Y, Uhara H, Iizuka H, Uehara J, Otsuka F, Fujisawa Y, Takenouchi T, Isei T, Iwatsuki K, et al. Cytokine biomarkers to predict antitumor responses to nivolumab suggested in a phase 2 study for advanced melanoma. Cancer Sci. 2017;108:1022-31. doi:10.1111/cas.13226. PMID:28266140
    • (2017) Cancer Sci , vol.108 , pp. 1022-1031
    • Yamazaki, N.1    Kiyohara, Y.2    Uhara, H.3    Iizuka, H.4    Uehara, J.5    Otsuka, F.6    Fujisawa, Y.7    Takenouchi, T.8    Isei, T.9    Iwatsuki, K.10
  • 252
  • 253
    • 84978634373 scopus 로고    scopus 로고
    • T cell receptor signalling in the control of regulatory T cell differentiation and function
    • 27026074,. PMID
    • Li MO, Rudensky AY. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol. 2016;16:220-33. doi:10.1038/nri.2016.26. PMID:27026074
    • (2016) Nat Rev Immunol , vol.16 , pp. 220-233
    • Li, M.O.1    Rudensky, A.Y.2
  • 254
    • 84903277871 scopus 로고    scopus 로고
    • Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
    • 24962260,. PMID
    • Pollizzi KN, Powell JD. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat Rev Immunol. 2014;14:435-46. doi:10.1038/nri3701. PMID:24962260
    • (2014) Nat Rev Immunol , vol.14 , pp. 435-446
    • Pollizzi, K.N.1    Powell, J.D.2
  • 255
    • 84989245025 scopus 로고    scopus 로고
    • Cancer: Tumour-specific ablation of Treg cells induces anticancer response
    • Flemming A. Cancer: Tumour-specific ablation of Treg cells induces anticancer response. Nat Rev Drug Discov. 2016;15:676-7. doi:10.1038/nrd.2016.198.
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 676-677
    • Flemming, A.1
  • 256
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • 22419253,. PMID
    • Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012;12:298-306. doi:10.1038/nrc3245. PMID:22419253
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3    Galon, J.4
  • 257
    • 85030623849 scopus 로고    scopus 로고
    • The immune contexture in cancer prognosis and treatment
    • 28741618,;in press. PMID
    • Fridman WH, Zitvogel L, Sautes-Fridman C, Kroemer G. The immune contexture in cancer prognosis and treatment. Nat Rev Clin Oncol. 2017;in press. doi:10.1038/nrclinonc.2017.101. PMID:28741618
    • (2017) Nat Rev Clin Oncol
    • Fridman, W.H.1    Zitvogel, L.2    Sautes-Fridman, C.3    Kroemer, G.4
  • 258
    • 85030168908 scopus 로고    scopus 로고
    • The regulation of immune tolerance by FOXP3
    • 28757603,;in press. PMID
    • Lu L, Barbi J, Pan F. The regulation of immune tolerance by FOXP3. Nat Rev Immunol. 2017;in press. doi:10.1038/nri.2017.75. PMID: 28757603
    • (2017) Nat Rev Immunol
    • Lu, L.1    Barbi, J.2    Pan, F.3
  • 260
    • 67650657178 scopus 로고    scopus 로고
    • Dacetuzumab, a humanized mAb against CD40 for the treatment of hematological malignancies
    • 19513947,. PMID
    • Khubchandani S, Czuczman MS, Hernandez-Ilizaliturri FJ. Dacetuzumab, a humanized mAb against CD40 for the treatment of hematological malignancies. Curr Opin Investig Drugs. 2009;10:579-87. PMID:19513947
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 579-587
    • Khubchandani, S.1    Czuczman, M.S.2    Hernandez-Ilizaliturri, F.J.3
  • 261
    • 70349334508 scopus 로고    scopus 로고
    • Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
    • 19636010,. PMID
    • Advani R, Forero-Torres A, Furman RR, Rosenblatt JD, Younes A, Ren H, Harrop K, Whiting N, Drachman JG. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol. 2009;27:4371-7. doi:10.1200/JCO.2008.21.3017. PMID:19636010
    • (2009) J Clin Oncol , vol.27 , pp. 4371-4377
    • Advani, R.1    Forero-Torres, A.2    Furman, R.R.3    Rosenblatt, J.D.4    Younes, A.5    Ren, H.6    Harrop, K.7    Whiting, N.8    Drachman, J.G.9
  • 262
    • 76349120845 scopus 로고    scopus 로고
    • A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
    • 20038235,. PMID
    • Furman RR, Forero-Torres A, Shustov A, Drachman JG. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2010;51:228-35. doi:10.3109/10428190903440946. PMID:20038235
    • (2010) Leuk Lymphoma , vol.51 , pp. 228-235
    • Furman, R.R.1    Forero-Torres, A.2    Shustov, A.3    Drachman, J.G.4
  • 263
    • 77952315198 scopus 로고    scopus 로고
    • A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma
    • 20133895,. PMID
    • Hussein M, Berenson JR, Niesvizky R, Munshi N, Matous J, Sobecks R, Harrop K, Drachman JG, Whiting N. A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma. Haematologica. 2010;95:845-8. doi:10.3324/haematol.2009.008003. PMID:20133895
    • (2010) Haematologica , vol.95 , pp. 845-848
    • Hussein, M.1    Berenson, J.R.2    Niesvizky, R.3    Munshi, N.4    Matous, J.5    Sobecks, R.6    Harrop, K.7    Drachman, J.G.8    Whiting, N.9
  • 265
    • 84959378533 scopus 로고    scopus 로고
    • Immunotherapy for cancer in the central nervous system: Current and future directions
    • 27057463,. PMID
    • Binder DC, Davis AA, Wainwright DA. Immunotherapy for cancer in the central nervous system: Current and future directions. Oncoimmunology. 2016;5:e1082027. doi:10.1080/2162402X.2015.1082027. PMID:27057463
    • (2016) Oncoimmunology , vol.5 , pp. 1082027
    • Binder, D.C.1    Davis, A.A.2    Wainwright, D.A.3
  • 268
    • 85026522198 scopus 로고    scopus 로고
    • PD-1/PD-L1 checkpoint blockades in non-small cell lung cancer: New development and challenges
    • 28688973,. PMID
    • Meng X, Liu Y, Zhang J, Teng F, Xing L, Yu J. PD-1/PD-L1 checkpoint blockades in non-small cell lung cancer: New development and challenges. Cancer Lett. 2017;405:29-37. doi:10.1016/j.canlet.2017.06.033. PMID:28688973
    • (2017) Cancer Lett , vol.405 , pp. 29-37
    • Meng, X.1    Liu, Y.2    Zhang, J.3    Teng, F.4    Xing, L.5    Yu, J.6
  • 269
    • 84994120928 scopus 로고    scopus 로고
    • PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas
    • 27805626,. PMID
    • Goodman A, Patel SP, Kurzrock R. PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas. Nat Rev Clin Oncol. 2017;14:203-20. doi:10.1038/nrclinonc.2016.168. PMID:27805626
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 203-220
    • Goodman, A.1    Patel, S.P.2    Kurzrock, R.3
  • 270
    • 84938350452 scopus 로고    scopus 로고
    • Combination cancer immunotherapy and new immunomodulatory targets
    • 26228759,. PMID
    • Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov. 2015;14:561-84. doi:10.1038/nrd4591. PMID:26228759
    • (2015) Nat Rev Drug Discov , vol.14 , pp. 561-584
    • Mahoney, K.M.1    Rennert, P.D.2    Freeman, G.J.3
  • 272
    • 84974803082 scopus 로고    scopus 로고
    • Radiotherapy: Changing the Game in Immunotherapy
    • 27774519,. PMID
    • Demaria S, Coleman CN, Formenti SC. Radiotherapy: Changing the Game in Immunotherapy. Trends Cancer. 2016;2:286-94. doi:10.1016/j.trecan.2016.05.002. PMID:27774519
    • (2016) Trends Cancer , vol.2 , pp. 286-294
    • Demaria, S.1    Coleman, C.N.2    Formenti, S.C.3
  • 273
    • 85040734981 scopus 로고    scopus 로고
    • Towards precision radiotherapy for use with immune checkpoint blockers
    • Vanpouille-Box C, Formenti SC, Demaria S. Towards precision radiotherapy for use with immune checkpoint blockers. Clin Cancer Res. 2017. doi:10.1158/1078-0432.CCR-16-0037.
    • (2017) Clin Cancer Res
    • Vanpouille-Box, C.1    Formenti, S.C.2    Demaria, S.3
  • 274
    • 84995370898 scopus 로고    scopus 로고
    • Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
    • 27845767,. PMID
    • Galluzzi L, Bravo-San Pedro JM, Demaria S, Formenti SC, Kroemer G. Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol. 2017;14:247-58. doi:10.1038/nrclinonc.2016.183. PMID:27845767
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 247-258
    • Galluzzi, L.1    Bravo-San Pedro, J.M.2    Demaria, S.3    Formenti, S.C.4    Kroemer, G.5
  • 275
    • 85007280340 scopus 로고    scopus 로고
    • Making the Most of Cancer Surgery with Neoadjuvant Immunotherapy
    • 27920139,. PMID
    • Melero I, Berraondo P, Rodriguez-Ruiz ME, Perez-Gracia JL. Making the Most of Cancer Surgery with Neoadjuvant Immunotherapy. Cancer Discov. 2016;6:1312-4. doi:10.1158/2159-8290.CD-16-1109. PMID:27920139
    • (2016) Cancer Discov , vol.6 , pp. 1312-1314
    • Melero, I.1    Berraondo, P.2    Rodriguez-Ruiz, M.E.3    Perez-Gracia, J.L.4
  • 276
    • 84891001835 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma-treatment approaches in the molecular era
    • 24217204,. PMID
    • Roschewski M, Staudt LM, Wilson WH. Diffuse large B-cell lymphoma-treatment approaches in the molecular era. Nat Rev Clin Oncol. 2014;11:12-23. doi:10.1038/nrclinonc.2013.197. PMID:24217204
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 12-23
    • Roschewski, M.1    Staudt, L.M.2    Wilson, W.H.3
  • 277
    • 84975882004 scopus 로고    scopus 로고
    • Combating rituximab resistance by inducing ceramide/lysosome-involved cell death through initiation of CD20-TNFR1 co-localization
    • 27467962, et al.,. PMID
    • Zhang F, Yang J, Li H, Liu M, Zhang J, Zhao L, Wang L, LingHu R, Feng F, Gao X, et al. Combating rituximab resistance by inducing ceramide/lysosome-involved cell death through initiation of CD20-TNFR1 co-localization. Oncoimmunology. 2016;5:e1143995. doi:10.1080/2162402X.2016.1143995. PMID:27467962
    • (2016) Oncoimmunology , vol.5 , pp. 1143995
    • Zhang, F.1    Yang, J.2    Li, H.3    Liu, M.4    Zhang, J.5    Zhao, L.6    Wang, L.7    LingHu, R.8    Feng, F.9    Gao, X.10
  • 278
    • 85025151450 scopus 로고    scopus 로고
    • Targeted therapies for renal cell carcinoma
    • 28691713,. PMID
    • Posadas EM, Limvorasak S, Figlin RA. Targeted therapies for renal cell carcinoma. Nat Rev Nephrol. 2017;13:496-511. doi:10.1038/nrneph.2017.82. PMID:28691713
    • (2017) Nat Rev Nephrol , vol.13 , pp. 496-511
    • Posadas, E.M.1    Limvorasak, S.2    Figlin, R.A.3
  • 279
    • 84940705588 scopus 로고    scopus 로고
    • A rationally designed combined treatment with an alphavirus-based cancer vaccine, sunitinib and low-dose tumor irradiation completely blocks tumor development
    • 26451295,. PMID
    • Draghiciu O, Boerma A, Hoogeboom BN, Nijman HW, Daemen T. A rationally designed combined treatment with an alphavirus-based cancer vaccine, sunitinib and low-dose tumor irradiation completely blocks tumor development. Oncoimmunology. 2015;4:e1029699. doi:10.1080/2162402X.2015.1029699. PMID:26451295
    • (2015) Oncoimmunology , vol.4 , pp. 1029699
    • Draghiciu, O.1    Boerma, A.2    Hoogeboom, B.N.3    Nijman, H.W.4    Daemen, T.5
  • 280
    • 85035352368 scopus 로고    scopus 로고
    • Improving outcomes in high-risk, nonmetastatic renal cancer: new data and ongoing trials
    • 28762388,;in press. PMID
    • Blick C, Ritchie AWS, Eisen T, Stewart GD. Improving outcomes in high-risk, nonmetastatic renal cancer: new data and ongoing trials. Nat Rev Urol. 2017;in press. doi:10.1038/nrurol.2017.123. PMID:28762388
    • (2017) Nat Rev Urol
    • Blick, C.1    Ritchie, A.W.S.2    Eisen, T.3    Stewart, G.D.4
  • 281
    • 84977125861 scopus 로고    scopus 로고
    • Combine and conquer: challenges for targeted therapy combinations in early phase trials
    • 27377132,. PMID
    • Lopez JS, Banerji U. Combine and conquer: challenges for targeted therapy combinations in early phase trials. Nat Rev Clin Oncol. 2017;14:57-66. doi:10.1038/nrclinonc.2016.96. PMID:27377132
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 57-66
    • Lopez, J.S.1    Banerji, U.2
  • 286
    • 84940451580 scopus 로고    scopus 로고
    • Translating nucleic acid-sensing pathways into therapies
    • 26292638,. PMID
    • Junt T, Barchet W. Translating nucleic acid-sensing pathways into therapies. Nat Rev Immunol. 2015;15:529-44. doi:10.1038/nri3875. PMID:26292638
    • (2015) Nat Rev Immunol , vol.15 , pp. 529-544
    • Junt, T.1    Barchet, W.2
  • 287
    • 77950542752 scopus 로고    scopus 로고
    • Targeting Toll-like receptors: emerging therapeutics?
    • 20380038,. PMID
    • Hennessy EJ, Parker AE, O'Neill LA. Targeting Toll-like receptors: emerging therapeutics? Nat Rev Drug Discov. 2010;9:293-307. doi:10.1038/nrd3203. PMID:20380038
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 293-307
    • Hennessy, E.J.1    Parker, A.E.2    O'Neill, L.A.3
  • 289
    • 84978522783 scopus 로고    scopus 로고
    • The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy
    • 27622042,. PMID
    • Roselli M, Formica V, Cereda V, Jochems C, Richards J, Grenga I, Orlandi A, Ferroni P, Guadagni F, Schlom J. The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy. Oncoimmunology. 2016;5:e1188243. doi:10.1080/2162402X.2016.1188243. PMID:27622042
    • (2016) Oncoimmunology , vol.5 , pp. 1188243
    • Roselli, M.1    Formica, V.2    Cereda, V.3    Jochems, C.4    Richards, J.5    Grenga, I.6    Orlandi, A.7    Ferroni, P.8    Guadagni, F.9    Schlom, J.10
  • 290
    • 84982131766 scopus 로고    scopus 로고
    • Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling
    • 27529514, et al.,. PMID
    • Baker LC, Boult JK, Thomas M, Koehler A, Nayak T, Tessier J, Ooi CH, Birzele F, Belousov A, Zajac M, et al. Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling. Br J Cancer. 2016;115:691-702. doi:10.1038/bjc.2016.236. PMID:27529514
    • (2016) Br J Cancer , vol.115 , pp. 691-702
    • Baker, L.C.1    Boult, J.K.2    Thomas, M.3    Koehler, A.4    Nayak, T.5    Tessier, J.6    Ooi, C.H.7    Birzele, F.8    Belousov, A.9    Zajac, M.10
  • 291
    • 84979224082 scopus 로고    scopus 로고
    • The use of CrossMAb technology for the generation of bi- and multispecific antibodies
    • 27285945,. PMID
    • Klein C, Schaefer W, Regula JT. The use of CrossMAb technology for the generation of bi- and multispecific antibodies. MAbs. 2016;8:1010-20. doi:10.1080/19420862.2016.1197457. PMID:27285945
    • (2016) MAbs , vol.8 , pp. 1010-1020
    • Klein, C.1    Schaefer, W.2    Regula, J.T.3
  • 292
    • 84961393064 scopus 로고    scopus 로고
    • Novel anti-angiogenic therapeutic strategies in colorectal cancer
    • 26938715,. PMID
    • Tampellini M, Sonetto C, Scagliotti GV. Novel anti-angiogenic therapeutic strategies in colorectal cancer. Expert Opin Investig Drugs. 2016;25:507-20. doi:10.1517/13543784.2016.1161754. PMID:26938715
    • (2016) Expert Opin Investig Drugs , vol.25 , pp. 507-520
    • Tampellini, M.1    Sonetto, C.2    Scagliotti, G.V.3
  • 293
    • 84961589082 scopus 로고    scopus 로고
    • Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model
    • 27141347,. PMID
    • Chang DK, Peterson E, Sun J, Goudie C, Drapkin RI, Liu JF, Matulonis U, Zhu Q, Marasco WA. Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model. Oncoimmunology. 2016;5:e1090075. doi:10.1080/2162402X.2015.1090075. PMID:27141347
    • (2016) Oncoimmunology , vol.5 , pp. 1090075
    • Chang, D.K.1    Peterson, E.2    Sun, J.3    Goudie, C.4    Drapkin, R.I.5    Liu, J.F.6    Matulonis, U.7    Zhu, Q.8    Marasco, W.A.9
  • 294
    • 84925358053 scopus 로고    scopus 로고
    • Mogamulizumab: 2 birds, 1 stone
    • 25792728,. PMID
    • Wilcox RA. Mogamulizumab: 2 birds, 1 stone. Blood. 2015;125:1847-8. doi:10.1182/blood-2015-02-625251. PMID:25792728
    • (2015) Blood , vol.125 , pp. 1847-1848
    • Wilcox, R.A.1
  • 295
    • 84938090300 scopus 로고    scopus 로고
    • CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study
    • 26179200, et al.,. PMID
    • Cassier PA, Italiano A, Gomez-Roca CA, Le Tourneau C, Toulmonde M, Cannarile MA, Ries C, Brillouet A, Muller C, Jegg AM, et al. CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study. Lancet Oncol. 2015;16:949-56. doi:10.1016/S1470-2045(15)00132-1. PMID:26179200
    • (2015) Lancet Oncol , vol.16 , pp. 949-956
    • Cassier, P.A.1    Italiano, A.2    Gomez-Roca, C.A.3    Le Tourneau, C.4    Toulmonde, M.5    Cannarile, M.A.6    Ries, C.7    Brillouet, A.8    Muller, C.9    Jegg, A.M.10
  • 297
    • 84944463983 scopus 로고    scopus 로고
    • Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors
    • 26155427,. PMID
    • Casbon AJ, Lohela M, Werb Z. Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors. Oncoimmunology. 2015;4:e1008871. doi:10.1080/2162402X.2015.1008871. PMID:26155427
    • (2015) Oncoimmunology , vol.4 , pp. 1008871
    • Casbon, A.J.1    Lohela, M.2    Werb, Z.3
  • 298
    • 84861735070 scopus 로고    scopus 로고
    • Treatment selection in metastatic renal cell carcinoma: expert consensus
    • 22473096,. PMID
    • Escudier B, Szczylik C, Porta C, Gore M. Treatment selection in metastatic renal cell carcinoma: expert consensus. Nat Rev Clin Oncol. 2012;9:327-37. doi:10.1038/nrclinonc.2012.59. PMID:22473096
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 327-337
    • Escudier, B.1    Szczylik, C.2    Porta, C.3    Gore, M.4
  • 299
    • 84886405297 scopus 로고    scopus 로고
    • Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity
    • 23965900,. PMID
    • Marabelle A, Kohrt H, Levy R. Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity. Clin Cancer Res. 2013;19:5261-3. doi:10.1158/1078-0432.CCR-13-1923. PMID:23965900
    • (2013) Clin Cancer Res , vol.19 , pp. 5261-5263
    • Marabelle, A.1    Kohrt, H.2    Levy, R.3
  • 300
    • 84886427186 scopus 로고    scopus 로고
    • Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects
    • 23788581,. PMID
    • Fransen MF, van der Sluis TC, Ossendorp F, Arens R, Melief CJ. Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects. Clin Cancer Res. 2013;19:5381-9. doi:10.1158/1078-0432.CCR-12-0781. PMID:23788581
    • (2013) Clin Cancer Res , vol.19 , pp. 5381-5389
    • Fransen, M.F.1    van der Sluis, T.C.2    Ossendorp, F.3    Arens, R.4    Melief, C.J.5
  • 303
    • 84994144900 scopus 로고    scopus 로고
    • Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets
    • 27811929,. PMID
    • Shi Y, Du L, Lin L, Wang Y. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov. 2017;16:35-52. doi:10.1038/nrd.2016.193. PMID:27811929
    • (2017) Nat Rev Drug Discov , vol.16 , pp. 35-52
    • Shi, Y.1    Du, L.2    Lin, L.3    Wang, Y.4
  • 304
    • 85010901048 scopus 로고    scopus 로고
    • Tumour-associated macrophages as treatment targets in oncology
    • 28117416,. PMID
    • Mantovani A, Marchesi F, Malesci A, Laghi L, Allavena P. Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. 2017;14:399-416. doi:10.1038/nrclinonc.2016.217. PMID:28117416
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 399-416
    • Mantovani, A.1    Marchesi, F.2    Malesci, A.3    Laghi, L.4    Allavena, P.5
  • 305
    • 84976272206 scopus 로고    scopus 로고
    • The role of myeloid cells in cancer therapies
    • 27339708,. PMID
    • Engblom C, Pfirschke C, Pittet MJ. The role of myeloid cells in cancer therapies. Nat Rev Cancer. 2016;16:447-62. doi:10.1038/nrc.2016.54. PMID:27339708
    • (2016) Nat Rev Cancer , vol.16 , pp. 447-462
    • Engblom, C.1    Pfirschke, C.2    Pittet, M.J.3
  • 306
    • 85009820249 scopus 로고    scopus 로고
    • Radiotherapy and immunotherapy: A beneficial liaison?
    • 28094262,. PMID
    • Weichselbaum RR, Liang H, Deng L, Fu YX. Radiotherapy and immunotherapy: A beneficial liaison? Nat Rev Clin Oncol. 2017;14:365-79. doi:10.1038/nrclinonc.2016.211. PMID:28094262
    • (2017) Nat Rev Clin Oncol , vol.14 , pp. 365-379
    • Weichselbaum, R.R.1    Liang, H.2    Deng, L.3    Fu, Y.X.4
  • 307
    • 84959133719 scopus 로고    scopus 로고
    • Combination cancer immunotherapies tailored to the tumour microenvironment
    • 26598942,. PMID
    • Smyth MJ, Ngiow SF, Ribas A, Teng MW. Combination cancer immunotherapies tailored to the tumour microenvironment. Nat Rev Clin Oncol. 2016;13:143-58. doi:10.1038/nrclinonc.2015.209. PMID:26598942
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 143-158
    • Smyth, M.J.1    Ngiow, S.F.2    Ribas, A.3    Teng, M.W.4
  • 308
    • 84969988539 scopus 로고    scopus 로고
    • The future of cancer treatment: immunomodulation, CARs and combination immunotherapy
    • 27118494,. PMID
    • Khalil DN, Smith EL, Brentjens RJ, Wolchok JD. The future of cancer treatment: immunomodulation, CARs and combination immunotherapy. Nat Rev Clin Oncol. 2016;13:394. doi:10.1038/nrclinonc.2016.65. PMID:27118494
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 394
    • Khalil, D.N.1    Smith, E.L.2    Brentjens, R.J.3    Wolchok, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.