OX40- and CD27-Mediated costimulation synergizes with Anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence

Journal of Immunology

Volumn 194, Issue 1, 2015, Pages 125-133

  Buchan, Sarah L ^a   Manzo, Teresa ^b   Flutter, Barry ^b   Rogel, Anne ^a   Edwards, Noha ^b   Zhang, Lei ^b   Sivakumaran, Shivajanani ^b   Ghorashian, Sara ^b   Carpenter, Ben ^b   Bennett, Clare L ^b   Freeman, Gordon J ^c   Sykes, Megan ^d   Croft, Michael ^e   Al Shamkhani, Aymen ^a   Chakraverty, Ronjon ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NewYork Presbyterian Hospital   (United States)

^e Institute of Allergy and Immunology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CD27 ANTIGEN; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN ANTIBODY; ANTIBODY; CD274 PROTEIN, MOUSE; MEMBRANE PROTEIN; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21; TNFRSF4 PROTEIN, MOUSE; TNFSF4 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; MALE; MOUSE; NONHUMAN; STEM CELL; T LYMPHOCYTE SUBPOPULATION; ADOPTIVE TRANSFER; ANIMAL; C57BL MOUSE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; TRANSPLANTATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES; ANTIGENS, CD27; ANTIGENS, CD274; BONE MARROW TRANSPLANTATION; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, OX40; T-BOX DOMAIN PROTEINS; TUMOR NECROSIS FACTORS;

EID: 84919632874     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401644     Document Type: Article

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