Tolerance and exhaustion: Defining mechanisms of T cell dysfunction

Trends in Immunology

Volumn 35, Issue 2, 2014, Pages 51-60

  Schietinger, Andrea ^a,b   Greenberg, Philip D ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

CD8 T cells; Chronic infection; Exhaustion; Self tolerance; T cell differentiation; T cell dysfunction; Tumors

Indexed keywords

IPILIMUMAB;

CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CELL FATE; CLONAL ANERGY; EPIGENETICS; EXHAUSTION; HUMAN; IMMUNE DEFICIENCY; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; MOLECULAR IMPRINTING; NONHUMAN; PLASTICITY; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

CD8 T CELLS; CHRONIC INFECTION; EXHAUSTION; SELF-TOLERANCE; T CELL DIFFERENTIATION; T CELL DYSFUNCTION; TUMORS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CLONAL ANERGY; EPIGENESIS, GENETIC; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; INFECTION; LYMPHOCYTE ACTIVATION; MICE; NEOPLASMS; SELF TOLERANCE;

EID: 84893711428     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2013.10.001     Document Type: Review

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