메뉴 건너뛰기




Volumn 2, Issue 2, 2017, Pages

Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer

Author keywords

CD8 + T cells; checkpoint inhibitors; exhaustion; immunotherapy; tumor microenvironment

Indexed keywords


EID: 85031736840     PISSN: None     EISSN: 20597029     Source Type: Journal    
DOI: 10.1136/esmoopen-2017-000213     Document Type: Review
Times cited : (263)

References (87)
  • 1
    • 0035903326 scopus 로고    scopus 로고
    • Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    • Hawiger D, Inaba K, Dorsett Y, et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001;194:769-80.
    • (2001) J Exp Med , vol.194 , pp. 769-780
    • Hawiger, D.1    Inaba, K.2    Dorsett, Y.3
  • 2
    • 0023143676 scopus 로고
    • Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
    • Jenkins MK, Schwartz RH. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 1987;165:302-19.
    • (1987) J Exp Med , vol.165 , pp. 302-319
    • Jenkins, M.K.1    Schwartz, R.H.2
  • 3
    • 0026537347 scopus 로고
    • CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
    • Harding FA, McArthur JG, Gross JA, et al. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992;356:607-9.
    • (1992) Nature , vol.356 , pp. 607-609
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3
  • 4
    • 84941343279 scopus 로고    scopus 로고
    • Releasing the brakes on cancer immunotherapy
    • Littman DR. Releasing the brakes on cancer immunotherapy. Cell 2015;162:1186-90.
    • (2015) Cell , vol.162 , pp. 1186-1190
    • Littman, D.R.1
  • 5
    • 35748969588 scopus 로고    scopus 로고
    • Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter
    • Gibson HM, Hedgcock CJ, Aufiero BM, et al. Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J Immunol 2007;179:3831-40.
    • (2007) J Immunol , vol.179 , pp. 3831-3840
    • Gibson, H.M.1    Hedgcock, C.J.2    Aufiero, B.M.3
  • 6
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y, Josefowicz SZ, Kas A, et al. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007;445:936-40.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3
  • 7
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to Cancer therapy
    • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to Cancer therapy. Cancer Cell 2015;27:450-61.
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 8
    • 84899758346 scopus 로고    scopus 로고
    • RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
    • Xiao Y, Yu S, Zhu B, et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 2014;211:943-59.
    • (2014) J Exp Med , vol.211 , pp. 943-959
    • Xiao, Y.1    Yu, S.2    Zhu, B.3
  • 9
    • 84864324543 scopus 로고    scopus 로고
    • Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
    • Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, et al. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med 2012;209:1201-17.
    • (2012) J Exp Med , vol.209 , pp. 1201-1217
    • Yokosuka, T.1    Takamatsu, M.2    Kobayashi-Imanishi, W.3
  • 10
    • 85015665428 scopus 로고    scopus 로고
    • T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
    • Hui E, Cheung J, Zhu J, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science 2017;355:1428-33.
    • (2017) Science , vol.355 , pp. 1428-1433
    • Hui, E.1    Cheung, J.2    Zhu, J.3
  • 11
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995;270:985-8.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 12
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    • Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 2001;291:319-22.
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1    Okazaki, T.2    Tanaka, Y.3
  • 13
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999;11:141-51.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3
  • 14
    • 84925625990 scopus 로고    scopus 로고
    • On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation
    • Lesokhin AM, Callahan MK, Postow MA, et al. On being less tolerant: enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation. Sci Transl Med 2015;7:280sr1.
    • (2015) Sci Transl Med , vol.7 , pp. 280sr1
    • Lesokhin, A.M.1    Callahan, M.K.2    Postow, M.A.3
  • 15
    • 84894266990 scopus 로고    scopus 로고
    • PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8 T cells induced by melanoma vaccines
    • Fourcade J, Sun Z, Pagliano O, et al. PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8 T cells induced by melanoma vaccines. Cancer Res 2014;74:1045-55.
    • (2014) Cancer Res , vol.74 , pp. 1045-1055
    • Fourcade, J.1    Sun, Z.2    Pagliano, O.3
  • 16
    • 85015817432 scopus 로고    scopus 로고
    • Tim-3 expression on tumor-Infiltrating PD-1(+)CD8(+) T cells correlates with poor clinical outcome in renal cell carcinoma
    • Granier C, Dariane C, Combe P, et al. Tim-3 expression on tumor-Infiltrating PD-1(+)CD8(+) T cells correlates with poor clinical outcome in renal cell carcinoma. Cancer Res 2017;77:1075-82.
    • (2017) Cancer Res , vol.77 , pp. 1075-1082
    • Granier, C.1    Dariane, C.2    Combe, P.3
  • 17
    • 84868669212 scopus 로고    scopus 로고
    • Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion
    • Rangachari M, Zhu C, Sakuishi K, et al. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion. Nat Med 2012;18:1394-400.
    • (2012) Nat Med , vol.18 , pp. 1394-1400
    • Rangachari, M.1    Zhu, C.2    Sakuishi, K.3
  • 18
    • 33847208485 scopus 로고    scopus 로고
    • PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
    • Davidson D, Schraven B, Veillette A. PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes. Mol Cell Biol 2007;27:1960-73.
    • (2007) Mol Cell Biol , vol.27 , pp. 1960-1973
    • Davidson, D.1    Schraven, B.2    Veillette, A.3
  • 19
    • 85011976409 scopus 로고    scopus 로고
    • Immune checkpoint receptors in cancer: Redundant by design?
    • Li J, Ni L, Dong C. Immune checkpoint receptors in cancer: redundant by design? Curr Opin Immunol 2017;45:37-42.
    • (2017) Curr Opin Immunol , vol.45 , pp. 37-42
    • Li, J.1    Ni, L.2    Dong, C.3
  • 20
    • 84923088133 scopus 로고    scopus 로고
    • An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
    • Zhu C, Sakuishi K, Xiao S, et al. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun 2015;6:6072.
    • (2015) Nat Commun , vol.6 , pp. 6072
    • Zhu, C.1    Sakuishi, K.2    Xiao, S.3
  • 21
    • 84903945401 scopus 로고    scopus 로고
    • LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses
    • Xu F, Liu J, Liu D, et al. LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses. Cancer Res 2014;74:3418-28.
    • (2014) Cancer Res , vol.74 , pp. 3418-3428
    • Xu, F.1    Liu, J.2    Liu, D.3
  • 22
    • 84962221817 scopus 로고    scopus 로고
    • Galectin-3 shapes antitumor immune responses by suppressing CD8+ T cells via LAG-3 and inhibiting expansion of plasmacytoid dendritic cells
    • Kouo T, Huang L, Pucsek AB, et al. Galectin-3 shapes antitumor immune responses by suppressing CD8+ T cells via LAG-3 and inhibiting expansion of plasmacytoid dendritic cells. Cancer Immunol Res 2015;3:412-23.
    • (2015) Cancer Immunol Res , vol.3 , pp. 412-423
    • Kouo, T.1    Huang, L.2    Pucsek, A.B.3
  • 23
    • 0038068048 scopus 로고    scopus 로고
    • The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells
    • Workman CJ, Vignali DA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 2003;33:970-9.
    • (2003) Eur J Immunol , vol.33 , pp. 970-979
    • Workman, C.J.1    Vignali, D.A.2
  • 24
    • 84990001695 scopus 로고    scopus 로고
    • VISTA is a novel broadspectrum negative checkpoint regulator for cancer immunotherapy
    • Lines JL, Sempere LF, Broughton T, et al. VISTA is a novel broadspectrum negative checkpoint regulator for cancer immunotherapy. Cancer Immunol Res 2014;2:510-7.
    • (2014) Cancer Immunol Res , vol.2 , pp. 510-517
    • Lines, J.L.1    Sempere, L.F.2    Broughton, T.3
  • 25
    • 79952717517 scopus 로고    scopus 로고
    • VISTA, a novel mouse ig superfamily ligand that negatively regulates T cell responses
    • Wang L, Rubinstein R, Lines JL, et al. VISTA, a novel mouse ig superfamily ligand that negatively regulates T cell responses. J Exp Med 2011;208:577-92.
    • (2011) J Exp Med , vol.208 , pp. 577-592
    • Wang, L.1    Rubinstein, R.2    Lines, J.L.3
  • 26
    • 0037340417 scopus 로고    scopus 로고
    • Lineage relationship and protective immunity of memory CD8 T cell subsets
    • Wherry EJ, Teichgräber V, Becker TC, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 2003;4:225-34.
    • (2003) Nat Immunol , vol.4 , pp. 225-234
    • Wherry, E.J.1    Teichgräber, V.2    Becker, T.C.3
  • 27
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigenspecific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M, Johnson LA, Heemskerk B, et al. Tumor antigenspecific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009;114:1537-44.
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3
  • 28
    • 85011635893 scopus 로고    scopus 로고
    • Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B
    • Fisicaro P, Barili V, Montanini B, et al. Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B. Nat Med 2017;23:327-36.
    • (2017) Nat Med , vol.23 , pp. 327-336
    • Fisicaro, P.1    Barili, V.2    Montanini, B.3
  • 29
    • 0027158798 scopus 로고
    • Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
    • Moskophidis D, Lechner F, Pircher H, et al. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 1993;362:758-61.
    • (1993) Nature , vol.362 , pp. 758-761
    • Moskophidis, D.1    Lechner, F.2    Pircher, H.3
  • 30
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • Zajac AJ, Blattman JN, Murali-Krishna K, et al. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 1998;188:2205-13.
    • (1998) J Exp Med , vol.188 , pp. 2205-2213
    • Zajac, A.J.1    Blattman, J.N.2    Murali-Krishna, K.3
  • 31
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • Wherry EJ, Blattman JN, Murali-Krishna K, et al. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol 2003;77:4911-27.
    • (2003) J Virol , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3
  • 32
    • 66949111877 scopus 로고    scopus 로고
    • PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients
    • Fourcade J, Kudela P, Sun Z, et al. PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients. J Immunol 2009;182:5240-9.
    • (2009) J Immunol , vol.182 , pp. 5240-5249
    • Fourcade, J.1    Kudela, P.2    Sun, Z.3
  • 33
    • 70349562580 scopus 로고    scopus 로고
    • Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression
    • Mumprecht S, Schürch C, Schwaller J, et al. Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression. Blood 2009;114:1528-36.
    • (2009) Blood , vol.114 , pp. 1528-1536
    • Mumprecht, S.1    Schürch, C.2    Schwaller, J.3
  • 34
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIVspecific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIVspecific T cells is associated with T-cell exhaustion and disease progression. Nature 2006;443:350-4.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1    Kaufmann, D.E.2    Kiepiela, P.3
  • 35
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 36
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 2002;99:12293-7.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3
  • 37
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:1039-800.
    • (2002) Nat Med , vol.8 , pp. 1039-1800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 38
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. T cell exhaustion. Nat Immunol 2011;12:492-9.
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 39
    • 84923026945 scopus 로고    scopus 로고
    • The transcription factor NFAT promotes exhaustion of activated CD8 T cells
    • Martinez GJ, Pereira RM, Äijo T, et al. The transcription factor NFAT promotes exhaustion of activated CD8 T cells. Immunity 2015;42:265-78.
    • (2015) Immunity , vol.42 , pp. 265-278
    • Martinez, G.J.1    Pereira, R.M.2    Äijo, T.3
  • 40
    • 34248399247 scopus 로고    scopus 로고
    • Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection
    • Agnellini P, Wolint P, Rehr M, et al. Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection. Proc Natl Acad Sci U S A 2007;104:4565-70.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4565-4570
    • Agnellini, P.1    Wolint, P.2    Rehr, M.3
  • 41
    • 85006747281 scopus 로고    scopus 로고
    • Dynamic changes in chromatin accessibility occur in CD8(+) T cells responding to viral infection
    • Scott-Browne JP, López-Moyado IF, Trifari S, et al. Dynamic changes in chromatin accessibility occur in CD8(+) T cells responding to viral infection. Immunity 2016;45:1327-40.
    • (2016) Immunity , vol.45 , pp. 1327-1340
    • Scott-Browne, J.P.1    López-Moyado, I.F.2    Trifari, S.3
  • 42
    • 84986285632 scopus 로고    scopus 로고
    • A distinct gene module for dysfunction uncoupled from activation in Tumor-Infiltrating T cells
    • Singer M, Wang C, Cong L, et al. A distinct gene module for dysfunction uncoupled from activation in Tumor-Infiltrating T cells. Cell 2016;166:1500-11.
    • (2016) Cell , vol.166 , pp. 1500-1511
    • Singer, M.1    Wang, C.2    Cong, L.3
  • 43
    • 85052690015 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder Cancer (UBC)
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder Cancer (UBC). ASCO annual meeting. J Clin Oncol 2014.
    • (2014) ASCO Annual Meeting. J Clin Oncol
  • 44
    • 85052715378 scopus 로고    scopus 로고
    • Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): Association of biomarkers with clinical outcomes
    • Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): Association of biomarkers with clinical outcomes. ASCO annual meetingChicago. J Clin Oncol 2015.
    • (2015) ASCO Annual MeetingChicago. J Clin Oncol
  • 45
    • 85052686976 scopus 로고    scopus 로고
    • Peripheral and tumor immune correlates in patients with advanced melanoma treated with combination nivolumab (anti-PD-1, BMS-936558, ONO-4538) and ipilimumab
    • Peripheral and tumor immune correlates in patients with advanced melanoma treated with combination nivolumab (anti-PD-1, BMS-936558, ONO-4538) and ipilimumab. ASCOChicago (Illinois). USA. J Clin Oncol 2013.
    • (2013) ASCOChicago (Illinois). USA. J Clin Oncol
  • 46
    • 85003055100 scopus 로고    scopus 로고
    • Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy
    • Ng Tang D, Shen Y, Sun J, et al. Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy. Cancer Immunol Res 2013;1:229-34.
    • (2013) Cancer Immunol Res , vol.1 , pp. 229-234
    • Ng Tang, D.1    Shen, Y.2    Sun, J.3
  • 47
    • 54449091476 scopus 로고    scopus 로고
    • CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
    • Online First: Epub Date
    • Liakou CI, Kamat A, Tang DN, et al. CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci U S A 2008;105:14987-92. Online First: Epub Date.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14987-14992
    • Liakou, C.I.1    Kamat, A.2    Tang, D.N.3
  • 48
    • 85052714221 scopus 로고    scopus 로고
    • Antitumor activity of the anti-pd-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor pd-l1 expression with outcome 105th annual meeting AACR
    • San Diego (CA).
    • Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor PD-L1 expression with outcome 105th Annual meeting AACR. 2014. San Diego (CA). Proceedings of the 105th Annual Meeting of the American Association for Cancer Research.
    • (2014) Proceedings of the 105th Annual Meeting of the American Association for Cancer Research
  • 49
    • 84894639687 scopus 로고    scopus 로고
    • Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab
    • Tarhini AA, Edington H, Butterfield LH, et al. Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab. PLoS One 2014;9:e87705.
    • (2014) PLoS One , vol.9 , pp. e87705
    • Tarhini, A.A.1    Edington, H.2    Butterfield, L.H.3
  • 50
    • 79959206459 scopus 로고    scopus 로고
    • CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans
    • Huang RR, Jalil J, Economou JS, et al. CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans. Clin Cancer Res 2011;17:4101-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 4101-4109
    • Huang, R.R.1    Jalil, J.2    Economou, J.S.3
  • 51
    • 52649088779 scopus 로고    scopus 로고
    • Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: Surrogate marker of efficacy of tremelimumab?
    • Ménard C, Ghiringhelli F, Roux S, et al. Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab? Clin Cancer Res 2008;14:5242-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 5242-5249
    • Ménard, C.1    Ghiringhelli, F.2    Roux, S.3
  • 52
    • 84902825664 scopus 로고    scopus 로고
    • Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients
    • Cha E, Klinger M, Hou Y, et al. Improved survival with T cell clonotype stability after anti-CTLA-4 treatment in cancer patients. Sci Transl Med 2014;6:238ra70.
    • (2014) Sci Transl Med , vol.6 , pp. 238ra70
    • Cha, E.1    Klinger, M.2    Hou, Y.3
  • 53
    • 84872841412 scopus 로고    scopus 로고
    • Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
    • van Rooij N, van Buuren MM, Philips D, et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J Clin Oncol 2013;31:e439-e442.
    • (2013) J Clin Oncol , vol.31 , pp. e439-e442
    • Van Rooij, N.1    Van Buuren, M.M.2    Philips, D.3
  • 54
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley PS, Greene JL, Brady W, et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994;793-801.
    • (1994) Immunity , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3
  • 55
    • 0042922822 scopus 로고    scopus 로고
    • Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
    • Bottino C, Castriconi R, Pende D, et al. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med 2003;198:557-67.
    • (2003) J Exp Med , vol.198 , pp. 557-567
    • Bottino, C.1    Castriconi, R.2    Pende, D.3
  • 56
    • 57849101994 scopus 로고    scopus 로고
    • The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
    • Yu X, Harden K, Gonzalez LC, et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 2009;10:48-57.
    • (2009) Nat Immunol , vol.10 , pp. 48-57
    • Yu, X.1    Harden, K.2    Gonzalez, L.C.3
  • 57
    • 84966738229 scopus 로고    scopus 로고
    • Coinhibitory pathways in the B7-CD28 ligand-receptor family
    • Schildberg FA, Klein SR, Freeman GJ, et al. Coinhibitory pathways in the B7-CD28 ligand-receptor family. Immunity 2016;44:955-72.
    • (2016) Immunity , vol.44 , pp. 955-972
    • Schildberg, F.A.1    Klein, S.R.2    Freeman, G.J.3
  • 58
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang CH, Curtis JD, Maggi LB, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 2013;153:1239-51.
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1    Curtis, J.D.2    Maggi, L.B.3
  • 59
    • 55249114228 scopus 로고    scopus 로고
    • Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
    • Cham CM, Driessens G, O'Keefe JP, et al. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur J Immunol 2008;38:2438-50.
    • (2008) Eur J Immunol , vol.38 , pp. 2438-2450
    • Cham, C.M.1    Driessens, G.2    O'Keefe, J.P.3
  • 60
    • 84941344937 scopus 로고    scopus 로고
    • Metabolic competition in the tumor microenvironment is a driver of Cancer progression
    • Chang CH, Qiu J, O'Sullivan D, et al. Metabolic competition in the tumor microenvironment is a driver of Cancer progression. Cell 2015;162:1229-41.
    • (2015) Cell , vol.162 , pp. 1229-1241
    • Chang, C.H.1    Qiu, J.2    O'Sullivan, D.3
  • 61
    • 84941366350 scopus 로고    scopus 로고
    • Phosphoenolpyruvate is a metabolic checkpoint of Anti-tumor T cell responses
    • Ho PC, Bihuniak JD, Macintyre AN, et al. Phosphoenolpyruvate is a metabolic checkpoint of Anti-tumor T cell responses. Cell 2015;162:1217-28.
    • (2015) Cell , vol.162 , pp. 1217-1228
    • Ho, P.C.1    Bihuniak, J.D.2    Macintyre, A.N.3
  • 62
    • 84951313126 scopus 로고    scopus 로고
    • Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
    • Zhao E, Maj T, Kryczek I, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol 2016;17:95-103.
    • (2016) Nat Immunol , vol.17 , pp. 95-103
    • Zhao, E.1    Maj, T.2    Kryczek, I.3
  • 63
    • 13444270323 scopus 로고    scopus 로고
    • Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
    • Hirano F, Kaneko K, Tamura H, et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 2005;65:1089-96.
    • (2005) Cancer Res , vol.65 , pp. 1089-1096
    • Hirano, F.1    Kaneko, K.2    Tamura, H.3
  • 64
    • 85002934321 scopus 로고    scopus 로고
    • Tumor-Intrinsic PD-L1 signals regulate cell growth, pathogenesis, and Autophagy in ovarian cancer and melanoma
    • Clark CA, Gupta HB, Sareddy G, et al. Tumor-Intrinsic PD-L1 signals regulate cell growth, pathogenesis, and Autophagy in ovarian cancer and melanoma. Cancer Res 2016;76:6964-74.
    • (2016) Cancer Res , vol.76 , pp. 6964-6974
    • Clark, C.A.1    Gupta, H.B.2    Sareddy, G.3
  • 65
    • 84871966600 scopus 로고    scopus 로고
    • PD-1-expressing tumorinfiltrating T cells are a favorable prognostic biomarker in HPVassociated head and neck cancer
    • Badoual C, Hans S, Merillon N, et al. PD-1-expressing tumorinfiltrating T cells are a favorable prognostic biomarker in HPVassociated head and neck cancer. Cancer Res 2013;73:128-38.
    • (2013) Cancer Res , vol.73 , pp. 128-138
    • Badoual, C.1    Hans, S.2    Merillon, N.3
  • 66
    • 85016074688 scopus 로고    scopus 로고
    • Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy
    • Roussel H, De Guillebon E, Biard L, et al. Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy. Oncoimmunology 2017;6:e1286437.
    • (2017) Oncoimmunology , vol.6 , pp. e1286437
    • Roussel, H.1    De Guillebon, E.2    Biard, L.3
  • 67
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • Ji RR, Chasalow SD, Wang L, et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother 2012;61:1019-31.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1019-1031
    • Ji, R.R.1    Chasalow, S.D.2    Wang, L.3
  • 68
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014;515:568-71.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3
  • 69
    • 84982946696 scopus 로고    scopus 로고
    • Analysis of immune signatures in longitudinal tumor samples yields Insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade
    • Chen PL, Roh W, Reuben A, et al. Analysis of immune signatures in longitudinal tumor samples yields Insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade. Cancer Discov 2016;6:827-37.
    • (2016) Cancer Discov , vol.6 , pp. 827-837
    • Chen, P.L.1    Roh, W.2    Reuben, A.3
  • 70
    • 84988266244 scopus 로고    scopus 로고
    • Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
    • Im SJ, Hashimoto M, Gerner MY, et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 2016;537:417-21.
    • (2016) Nature , vol.537 , pp. 417-421
    • Im, S.J.1    Hashimoto, M.2    Gerner, M.Y.3
  • 71
    • 84981285538 scopus 로고    scopus 로고
    • CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles
    • Leong YA, Chen Y, Ong HS, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol 2016;17:1187-96.
    • (2016) Nat Immunol , vol.17 , pp. 1187-1196
    • Leong, Y.A.1    Chen, Y.2    Ong, H.S.3
  • 72
    • 84988410229 scopus 로고    scopus 로고
    • Follicular CXCR5-expressing CD8(+) T cells curtail chronic viral infection
    • He R, Hou S, Liu C, et al. Follicular CXCR5-expressing CD8(+) T cells curtail chronic viral infection. Nature 2016;537:412-28.
    • (2016) Nature , vol.537 , pp. 412-428
    • He, R.1    Hou, S.2    Liu, C.3
  • 73
    • 85015679329 scopus 로고    scopus 로고
    • Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent
    • Kamphorst AO, Wieland A, Nasti T, et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science 2017;355:1423-7.
    • (2017) Science , vol.355 , pp. 1423-1427
    • Kamphorst, A.O.1    Wieland, A.2    Nasti, T.3
  • 74
    • 84870230232 scopus 로고    scopus 로고
    • Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection
    • Paley MA, Kroy DC, Odorizzi PM, et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 2012;338:1220-5.
    • (2012) Science , vol.338 , pp. 1220-1225
    • Paley, M.A.1    Kroy, D.C.2    Odorizzi, P.M.3
  • 75
    • 84864378851 scopus 로고    scopus 로고
    • Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection
    • Angelosanto JM, Blackburn SD, Crawford A, et al. Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection. J Virol 2012;86:8161-70.
    • (2012) J Virol , vol.86 , pp. 8161-8170
    • Angelosanto, J.M.1    Blackburn, S.D.2    Crawford, A.3
  • 76
    • 84958555198 scopus 로고    scopus 로고
    • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
    • Koyama S, Akbay EA, Li YY, Yy L, et al. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat Commun 2016;7:10501.
    • (2016) Nat Commun , vol.7 , pp. 10501
    • Koyama, S.1    Akbay, E.A.2    Li, Y.Y.3    Yy, L.4
  • 77
    • 85009205136 scopus 로고    scopus 로고
    • Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck Cancer
    • Shayan G, Srivastava R, Li J, et al. Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck Cancer. Oncoimmunology 2017;6:e1261779.
    • (2017) Oncoimmunology , vol.6 , pp. e1261779
    • Shayan, G.1    Srivastava, R.2    Li, J.3
  • 78
    • 85019914536 scopus 로고    scopus 로고
    • Induction of resident memory T cells enhances the efficacy of cancer vaccine
    • Nizard M, Roussel H, Diniz MO, et al. Induction of resident memory T cells enhances the efficacy of cancer vaccine. Nat Commun 2017;8:15221.
    • (2017) Nat Commun , vol.8 , pp. 15221
    • Nizard, M.1    Roussel, H.2    Diniz, M.O.3
  • 79
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010;236:219-42.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 80
    • 84898681799 scopus 로고    scopus 로고
    • Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
    • Joller N, Lozano E, Burkett PR, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 2014;40:569-81.
    • (2014) Immunity , vol.40 , pp. 569-581
    • Joller, N.1    Lozano, E.2    Burkett, P.R.3
  • 81
    • 84946771300 scopus 로고    scopus 로고
    • TIGIT predominantly regulates the immune response via regulatory T cells
    • Kurtulus S, Sakuishi K, Ngiow SF, et al. TIGIT predominantly regulates the immune response via regulatory T cells. J Clin Invest 2015;125:4053-62.
    • (2015) J Clin Invest , vol.125 , pp. 4053-4062
    • Kurtulus, S.1    Sakuishi, K.2    Ngiow, S.F.3
  • 82
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008;322:271-5.
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 83
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson TR, Li F, Montalvo-Ortiz W, et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013;210:1695-710.
    • (2013) J Exp Med , vol.210 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3
  • 84
    • 84884229186 scopus 로고    scopus 로고
    • Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptortargeting antibodies
    • Bulliard Y, Jolicoeur R, Windman M, et al. Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptortargeting antibodies. J Exp Med 2013;210:1685-93.
    • (2013) J Exp Med , vol.210 , pp. 1685-1693
    • Bulliard, Y.1    Jolicoeur, R.2    Windman, M.3
  • 85
    • 84994364943 scopus 로고    scopus 로고
    • Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
    • Pauken KE, Sammons MA, Odorizzi PM, et al. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science 2016;354:1160-5.
    • (2016) Science , vol.354 , pp. 1160-1165
    • Pauken, K.E.1    Sammons, M.A.2    Odorizzi, P.M.3
  • 86
    • 85016548232 scopus 로고    scopus 로고
    • Elements of cancer immunity and the cancerimmune set point
    • Chen DS, Mellman I. Elements of cancer immunity and the cancerimmune set point. Nature 2017;541:321-30.
    • (2017) Nature , vol.541 , pp. 321-330
    • Chen, D.S.1    Mellman, I.2
  • 87
    • 85016842928 scopus 로고    scopus 로고
    • Is there still room for cancer vaccines at the era of checkpoint inhibitors
    • Karaki S, Anson M, Tran T, et al. Is there still room for cancer vaccines at the era of checkpoint inhibitors. Vaccines 2016;4:37.
    • (2016) Vaccines , vol.4 , pp. 37
    • Karaki, S.1    Anson, M.2    Tran, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.