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Volumn 14, Issue 8, 2017, Pages 463-482

Targeted agents and immunotherapies: Optimizing outcomes in melanoma

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BCL2 RELATED PROTEIN A1; BINIMETINIB; COBIMETINIB; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DABRAFENIB; DACARBAZINE; IPILIMUMAB; MITOGEN ACTIVATED PROTEIN KINASE; NIVOLUMAB; PEMBROLIZUMAB; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLACEBO; TALIMOGENE LAHERPAREPVEC; TRAMETINIB; TUMOR MARKER; VEMURAFENIB;

EID: 85017108448     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2017.43     Document Type: Review
Times cited : (954)

References (171)
  • 1
    • 84876714102 scopus 로고    scopus 로고
    • Chemotherapy in the management of advanced cutaneous malignant melanoma
    • Luke, J. J., Schwartz, G. K. Chemotherapy in the management of advanced cutaneous malignant melanoma. Clin. Dermatol. 31, 290-297 (2013).
    • (2013) Clin. Dermatol. , vol.31 , pp. 290-297
    • Luke, J.J.1    Schwartz, G.K.2
  • 2
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins, M. B. et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993. J. Clin. Oncol. 17, 2105-2116 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2105-2116
    • Atkins, M.B.1
  • 3
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 4
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach, D. R., Krummel, M. F., Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734-1736 (1996).
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 5
    • 84935009372 scopus 로고    scopus 로고
    • Genomic classification of cutaneous melanoma
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Genomic classification of cutaneous melanoma. Cell 161, 1681-1696 (2015).
    • (2015) Cell , vol.161 , pp. 1681-1696
  • 6
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013).
    • (2013) Science , vol.339 , pp. 1546-1558
    • Vogelstein, B.1
  • 7
    • 85022209780 scopus 로고    scopus 로고
    • Efficacy and safety of programmed death receptor-1 (PD-1) blockade in metastatic uveal melanoma (UM
    • 9507
    • Tsai, K. K. et al. Efficacy and safety of programmed death receptor-1 (PD-1) blockade in metastatic uveal melanoma (UM). J. Clin. Oncol. 34 (Suppl.), abstr. 9507 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Tsai, K.K.1
  • 8
    • 84885172487 scopus 로고    scopus 로고
    • Clinical activity of ipilimumab for metastatic uveal melanoma: A retrospective review of the Dana-Farber Cancer Institute, Massachusetts general hospital, memorial sloan-kettering cancer center, and university hospital of lausanne experience
    • Luke, J. J. et al. Clinical activity of ipilimumab for metastatic uveal melanoma: A retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience. Cancer 119, 3687-3695 (2013).
    • (2013) Cancer , vol.119 , pp. 3687-3695
    • Luke, J.J.1
  • 9
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin, J. A. et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135-2147 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2135-2147
    • Curtin, J.A.1
  • 10
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types
    • Kamb, A. et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 264, 436-440 (1994).
    • (1994) Science , vol.264 , pp. 436-440
    • Kamb, A.1
  • 11
    • 0021258276 scopus 로고
    • Transforming ras genes from human melanoma: A manifestation of tumour heterogeneity
    • Albino, A. P., Le Strange, R., Oliff, A. I., Furth, M. E., Old, L. J. Transforming ras genes from human melanoma: A manifestation of tumour heterogeneity Nature 308, 69-72 (1984).
    • (1984) Nature , vol.308 , pp. 69-72
    • Albino, A.P.1    Le Strange, R.2    Oliff, A.I.3    Furth, M.E.4    Old, L.J.5
  • 12
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Guldberg, P. et al. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res. 57, 3660-3663 (1997).
    • (1997) Cancer Res , vol.57 , pp. 3660-3663
    • Guldberg, P.1
  • 13
    • 84946887722 scopus 로고    scopus 로고
    • The genetic evolution of melanoma from precursor lesions
    • Shain, A. H. et al. The genetic evolution of melanoma from precursor lesions. N. Engl. J. Med. 373, 1926-1936 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 1926-1936
    • Shain, A.H.1
  • 14
    • 65649147543 scopus 로고    scopus 로고
    • BrafV600E cooperates with Pten loss to induce metastatic melanoma
    • Dankort, D. et al. BrafV600E cooperates with Pten loss to induce metastatic melanoma. Nat. Genet. 41, 544-552 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 544-552
    • Dankort, D.1
  • 15
    • 1842589300 scopus 로고    scopus 로고
    • Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines
    • Melnikova, V. O., Bolshakov, S. V., Walker, C., Ananthaswamy, H. N. Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines. Oncogene 23, 2347-2356 (2004).
    • (2004) Oncogene , vol.23 , pp. 2347-2356
    • Melnikova, V.O.1    Bolshakov, S.V.2    Walker, C.3    Ananthaswamy, H.N.4
  • 16
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012).
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 17
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin, J. A., Busam, K., Pinkel, D., Bastian, B. C. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 24, 4340-4346 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 18
    • 79953324920 scopus 로고    scopus 로고
    • Large-scale analysis of KIT aberrations in Chinese patients with melanoma
    • Kong, Y. et al. Large-scale analysis of KIT aberrations in Chinese patients with melanoma. Clin. Cancer Res. 17, 1684-1691 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1684-1691
    • Kong, Y.1
  • 19
    • 79953325104 scopus 로고    scopus 로고
    • PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
    • Paraiso, K. H. et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res. 71, 2750-2760 (2011).
    • (2011) Cancer Res , vol.71 , pp. 2750-2760
    • Paraiso, K.H.1
  • 20
    • 84891898344 scopus 로고    scopus 로고
    • Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
    • Shi, H. et al. Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. Cancer Discov. 4, 80-93 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 80-93
    • Shi, H.1
  • 21
    • 84883482902 scopus 로고    scopus 로고
    • Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436
    • Nathanson, K. L. et al. Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436). Clin. Cancer Res. 19, 4868-4878 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 4868-4878
    • Nathanson, K.L.1
  • 22
    • 84978034236 scopus 로고    scopus 로고
    • Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    • Long, G. V. et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J. Clin. Oncol. 29, 1239-1246 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1239-1246
    • Long, G.V.1
  • 23
    • 84862584008 scopus 로고    scopus 로고
    • Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma
    • Menzies, A. M. et al. Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. Clin. Cancer Res. 18, 3242-3249 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3242-3249
    • Menzies, A.M.1
  • 24
    • 84874943389 scopus 로고    scopus 로고
    • BRAF inhibitor activity in V600R metastatic melanoma
    • Klein, O. et al. BRAF inhibitor activity in V600R metastatic melanoma. Eur. J. Cancer 49, 1073-1079 (2013).
    • (2013) Eur. J. Cancer , vol.49 , pp. 1073-1079
    • Klein, O.1
  • 25
    • 84874518093 scopus 로고    scopus 로고
    • Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma
    • Greaves, W. O. et al. Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma. J. Mol. Diagn. 15, 220-226 (2013).
    • (2013) J. Mol. Diagn. , vol.15 , pp. 220-226
    • Greaves, W.O.1
  • 26
    • 84866342282 scopus 로고    scopus 로고
    • BRAFL597 mutations in melanoma are associated with sensitivity to MEK inhibitors
    • Dahlman, K. B. et al. BRAFL597 mutations in melanoma are associated with sensitivity to MEK inhibitors. Cancer Discov. 2, 791-797 (2012).
    • (2012) Cancer Discov , vol.2 , pp. 791-797
    • Dahlman, K.B.1
  • 27
    • 84886292349 scopus 로고    scopus 로고
    • Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy
    • Botton, T. et al. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment Cell Melanoma Res. 26, 845-851 (2013).
    • (2013) Pigment Cell Melanoma Res , vol.26 , pp. 845-851
    • Botton, T.1
  • 28
    • 84926131772 scopus 로고    scopus 로고
    • Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanoma
    • Bowyer, S. E. et al. Activity of trametinib in K601E and L597Q BRAF mutation-positive metastatic melanoma. Melanoma Res. 24, 504-508 (2014).
    • (2014) Melanoma Res , vol.24 , pp. 504-508
    • Bowyer, S.E.1
  • 29
    • 84861740806 scopus 로고    scopus 로고
    • Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib
    • Sen, B. et al. Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. Sci. Transl Med. 4, 136ra70 (2012).
    • (2012) Sci. Transl Med. , vol.4 , pp. 136-170
    • Sen, B.1
  • 30
    • 0036895599 scopus 로고    scopus 로고
    • Missense mutations of the BRAF gene in human lung adenocarcinoma
    • Naoki, K., Chen, T. H., Richards, W. G., Sugarbaker, D. J., Meyerson, M. Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res. 62, 7001-7003 (2002).
    • (2002) Cancer Res , vol.62 , pp. 7001-7003
    • Naoki, K.1    Chen, T.H.2    Richards, W.G.3    Sugarbaker, D.J.4    Meyerson, M.5
  • 31
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan, P. T. et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116, 855-867 (2004).
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1
  • 32
    • 84942319957 scopus 로고    scopus 로고
    • BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition
    • Yao, Z. et al. BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition. Cancer Cell 28, 370-383 (2015).
    • (2015) Cancer Cell , vol.28 , pp. 370-383
    • Yao, Z.1
  • 33
    • 79958066836 scopus 로고    scopus 로고
    • KIT as a therapeutic target in metastatic melanoma
    • Carvajal, R. D. et al. KIT as a therapeutic target in metastatic melanoma. JAMA 305, 2327-2334 (2011).
    • (2011) JAMA , vol.305 , pp. 2327-2334
    • Carvajal, R.D.1
  • 34
    • 84881512367 scopus 로고    scopus 로고
    • Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin
    • Hodi, F. S. et al. Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. J. Clin. Oncol. 31, 3182-3190 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3182-3190
    • Hodi, F.S.1
  • 35
    • 79960708519 scopus 로고    scopus 로고
    • Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
    • Guo, J. et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J. Clin. Oncol. 29, 2904-2909 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2904-2909
    • Guo, J.1
  • 36
    • 84892945383 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study
    • Thomas, N. E. et al. Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study. J. Clin. Oncol. 31, 4252-4259 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4252-4259
    • Thomas, N.E.1
  • 37
    • 84892719835 scopus 로고    scopus 로고
    • Transcriptional profiling of melanoma sentinel nodes identify patients with poor outcome and reveal an association of CD30+ T lymphocytes with progression
    • Vallacchi, V. et al. Transcriptional profiling of melanoma sentinel nodes identify patients with poor outcome and reveal an association of CD30+ T lymphocytes with progression. Cancer Res. 74, 130-140 (2014).
    • (2014) Cancer Res , vol.74 , pp. 130-140
    • Vallacchi, V.1
  • 38
    • 0027165558 scopus 로고
    • The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
    • Brichard, V. et al. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178, 489-495 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 489-495
    • Brichard, V.1
  • 39
    • 0035957422 scopus 로고    scopus 로고
    • CD4+ T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: Association with NY-ESO-1 antibody production
    • Zeng, G., Wang, X., Robbins, P. F., Rosenberg, S. A., Wang, R. F. CD4+ T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: Association with NY-ESO-1 antibody production. Proc. Natl Acad. Sci. USA 98, 3964-3969 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3964-3969
    • Zeng, G.1    Wang, X.2    Robbins, P.F.3    Rosenberg, S.A.4    Wang, R.F.5
  • 40
    • 0035110963 scopus 로고    scopus 로고
    • Use of an in vitro immunoselected tumor line to identify shared melanoma antigens recognized by HLA-A0201-restricted T cells
    • Harada, M., Li, Y. F., El-Gamil, M., Rosenberg, S. A., Robbins, P. F. Use of an in vitro immunoselected tumor line to identify shared melanoma antigens recognized by HLA-A 0201-restricted T cells. Cancer Res. 61, 1089-1094 (2001).
    • (2001) Cancer Res , vol.61 , pp. 1089-1094
    • Harada, M.1    Li, Y.F.2    El-Gamil, M.3    Rosenberg, S.A.4    Robbins, P.F.5
  • 41
    • 0033949981 scopus 로고    scopus 로고
    • Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma
    • Kawakami, Y. et al. Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma. J. Immunother. 23, 17-27 (2000).
    • (2000) J. Immunother. , vol.23 , pp. 17-27
    • Kawakami, Y.1
  • 42
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12, 252-264 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 43
    • 84982144414 scopus 로고    scopus 로고
    • Regulatory circuits of T cell function in cancer
    • Speiser, D. E., Ho, P. C., Verdeil, G. Regulatory circuits of T cell function in cancer. Nat. Rev. Immunol. 16, 599-611 (2016).
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 599-611
    • Speiser, D.E.1    Ho, P.C.2    Verdeil, G.3
  • 44
    • 84980602745 scopus 로고    scopus 로고
    • Efficacy and safety of nivolumab in patients with BRAF V600 mutant and BRAF wild-type advanced melanoma: A pooled analysis of 4 clinical trials
    • Larkin, J. et al. Efficacy and safety of nivolumab in patients with BRAF V600 mutant and BRAF wild-type advanced melanoma: A pooled analysis of 4 clinical trials. JAMA Oncol. 1, 433-440 (2015).
    • (2015) JAMA Oncol , vol.1 , pp. 433-440
    • Larkin, J.1
  • 45
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • Robert, C. et al. Pembrolizumab versus ipilimumab in advanced melanoma. N. Engl. J. Med. 372, 2521-2532 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2521-2532
    • Robert, C.1
  • 46
    • 84947285069 scopus 로고    scopus 로고
    • Analysis of BRAF and NRAS mutation status in advanced melanoma patients treated with anti-CTLA-4 antibodies: Association with overall survival
    • Mangana, J. et al. Analysis of BRAF and NRAS mutation status in advanced melanoma patients treated with anti-CTLA-4 antibodies: Association with overall survival PLoS ONE 10, e0139438 (2015).
    • (2015) PLoS ONE , vol.10 , pp. 0139438
    • Mangana, J.1
  • 47
    • 84873346707 scopus 로고    scopus 로고
    • Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma
    • Flaherty, K. T. et al. Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma. J. Clin. Oncol. 31, 373-379 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 373-379
    • Flaherty, K.T.1
  • 48
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag, G. et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467, 596-599 (2010).
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1
  • 49
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman, P. B. et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364, 2507-2516 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1
  • 50
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1
    • Eisenhauer, E. A. et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
    • (2009) Eur. J. Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1
  • 51
    • 84896714827 scopus 로고    scopus 로고
    • Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study
    • McArthur, G. A. et al. Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): Extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 15, 323-332 (2014).
    • (2014) Lancet Oncol , vol.15 , pp. 323-332
    • McArthur, G.A.1
  • 52
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild, A. et al. Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet 380, 358-365 (2012).
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1
  • 53
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • Flaherty, K. T. et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N. Engl. J. Med. 367, 107-114 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 107-114
    • Flaherty, K.T.1
  • 54
    • 79951961755 scopus 로고    scopus 로고
    • Resistance to BRAF inhibition in melanomas
    • Solit, D. B., Rosen, N. Resistance to BRAF inhibition in melanomas. N. Engl. J. Med. 364, 772-774 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 772-774
    • Solit, D.B.1    Rosen, N.2
  • 55
    • 84879467934 scopus 로고    scopus 로고
    • Ipilimumab vemurafenib, dabrafenib, and trametinib: Synergistic competitors in the clinical management of BRAF mutant malignant melanoma
    • Luke, J. J., Hodi, F. S. Ipilimumab, vemurafenib, dabrafenib, and trametinib: Synergistic competitors in the clinical management of BRAF mutant malignant melanoma. Oncologist 18, 717-725 (2013).
    • (2013) Oncologist , vol.18 , pp. 717-725
    • Luke, J.J.1    Hodi, F.S.2
  • 56
    • 84862908097 scopus 로고    scopus 로고
    • RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
    • Su, F. et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N. Engl. J. Med. 366, 207-215 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 207-215
    • Su, F.1
  • 57
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou, G. et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464, 431-435 (2010).
    • (2010) Nature , vol.464 , pp. 431-435
    • Hatzivassiliou, G.1
  • 58
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn, S. J. et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 140, 209-221 (2010).
    • (2010) Cell , vol.140 , pp. 209-221
    • Heidorn, S.J.1
  • 59
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos, P. I., Zhang, C., Bollag, G., Shokat, K. M., Rosen, N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464, 427-430 (2010).
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 60
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty, K. T. et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N. Engl. J. Med. 367, 1694-1703 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1
  • 61
    • 84916895694 scopus 로고    scopus 로고
    • Updated overall survival (OS) for BRF113220 a phase 1-2 study of dabrafenib (D) alone versus combined dabrafenib and trametinib (D+T) in pts with BRAF V600 mutation-positive (+) metastatic melanoma (MM)
    • 9010
    • Flaherty, K. et al. Updated overall survival (OS) for BRF113220, a phase 1-2 study of dabrafenib (D) alone versus combined dabrafenib and trametinib (D+T) in pts with BRAF V600 mutation-positive (+) metastatic melanoma (MM). J. Clin. Oncol. 32 (Suppl.), abstr. 9010 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Flaherty, K.1
  • 62
    • 84938739283 scopus 로고    scopus 로고
    • Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial
    • Long, G. V. et al. Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial. Lancet 386, 444-451 (2015).
    • (2015) Lancet , vol.386 , pp. 444-451
    • Long, G.V.1
  • 63
    • 84920394727 scopus 로고    scopus 로고
    • Improved overall survival in melanoma with combined dabrafenib and trametinib
    • Robert, C. et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N. Engl. J. Med. 372, 30-39 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 30-39
    • Robert, C.1
  • 64
    • 84977929608 scopus 로고    scopus 로고
    • Two year estimate of overall survival in COMBI-v a randomized open-label phase III study comparing the combination of dabrafenib (D) and trametinib (T) with vemurafenib (Vem) as first-line therapy in patients (pts) with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma [abstract 3301]
    • Robert, C. et al. Two year estimate of overall survival in COMBI-v, a randomized, open-label, phase III study comparing the combination of dabrafenib (D) and trametinib (T) with vemurafenib (Vem) as first-line therapy in patients (pts) with unresectable or metastatic BRAF V600E/K mutation-positive cutaneous melanoma [abstract 3301]. Eur. J. Cancer 51 (Suppl. 3), S663 (2015).
    • (2015) Eur. J. Cancer , vol.51 , pp. S663
    • Robert, C.1
  • 65
    • 84904916223 scopus 로고    scopus 로고
    • Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600-mutated melanoma: A phase 1b study
    • Ribas, A. et al. Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600-mutated melanoma: A phase 1b study. Lancet Oncol. 15, 954-965 (2014).
    • (2014) Lancet Oncol , vol.15 , pp. 954-965
    • Ribas, A.1
  • 66
    • 84908245075 scopus 로고    scopus 로고
    • Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
    • Larkin, J. et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N. Engl. J. Med. 371, 1867-1876 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1867-1876
    • Larkin, J.1
  • 67
    • 84990175720 scopus 로고    scopus 로고
    • Impact of baseline genetic heterogeneities on progression-free survival (PFS) in patients (pts) with advanced BRAFV600-mutated melanoma treated with cobimetinib (COBI) + vemurafenib (VEM) in the phase 3 coBRIM study [abstract 25LBA]
    • McArthur, G. et al. Impact of baseline genetic heterogeneities on progression-free survival (PFS) in patients (pts) with advanced BRAFV600-mutated melanoma treated with cobimetinib (COBI) + vemurafenib (VEM) in the phase 3 coBRIM study [abstract 25LBA]. Eur. J. Cancer 51 (Suppl. 3), S722-S723 (2015).
    • (2015) Eur. J. Cancer , vol.51 , pp. S722-S723
    • McArthur, G.1
  • 68
    • 84994499942 scopus 로고    scopus 로고
    • Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): Updated efficacy results from a randomised, double-blind, phase 3 trial
    • Ascierto, P. A. et al. Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): Updated efficacy results from a randomised, double-blind, phase 3 trial. Lancet Oncol. 17, 1248-1260 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 1248-1260
    • Ascierto, P.A.1
  • 70
    • 84929898194 scopus 로고    scopus 로고
    • BRAF and MEK inhibition for the treatment of advanced BRAF mutant melanoma
    • Richman, J., Martin-Liberal, J., Diem, S., Larkin, J. BRAF and MEK inhibition for the treatment of advanced BRAF mutant melanoma. Expert Opin. Pharmacother. 16, 1285-1297 (2015).
    • (2015) Expert Opin. Pharmacother. , vol.16 , pp. 1285-1297
    • Richman, J.1    Martin-Liberal, J.2    Diem, S.3    Larkin, J.4
  • 71
    • 84875235432 scopus 로고    scopus 로고
    • MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 study
    • Ascierto, P. A. et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 study. Lancet Oncol. 14, 249-256 (2013).
    • (2013) Lancet Oncol , vol.14 , pp. 249-256
    • Ascierto, P.A.1
  • 72
    • 84990226859 scopus 로고    scopus 로고
    • Results of NEMO: A phase III trial of binimetinib (BINI) versus dacarbazine (DTIC) in NRAS-mutant cutaneous melanoma
    • 9500
    • Dummer, R. et al. Results of NEMO: A phase III trial of binimetinib (BINI) versus dacarbazine (DTIC) in NRAS-mutant cutaneous melanoma. J. Clin. Oncol. 34 (Suppl.), abstr. 9500 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Dummer, R.1
  • 73
    • 84870289371 scopus 로고    scopus 로고
    • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
    • Kwong, L. N. et al. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat. Med. 18, 1503-1510 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1503-1510
    • Kwong, L.N.1
  • 74
    • 84855921054 scopus 로고    scopus 로고
    • P53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition
    • Ji, Z. et al. p53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition. J. Invest. Dermatol. 132, 356-364 (2012).
    • (2012) J. Invest. Dermatol. , vol.132 , pp. 356-364
    • Ji, Z.1
  • 75
    • 83355170673 scopus 로고    scopus 로고
    • Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway
    • Atefi, M. et al. Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway. PLoS ONE 6, e28973 (2011).
    • (2011) PLoS ONE , vol.6 , pp. 28973
    • Atefi, M.1
  • 77
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 78
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert, C. et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364, 2517-2526 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2517-2526
    • Robert, C.1
  • 79
    • 85020534683 scopus 로고    scopus 로고
    • Overall survival (OS) and safety results from a phase 3 trial of ipilimumab (IPI) at 3 mg/kg versus 10 mg/kg in patients with metastatic melanoma (MEL
    • 1106O
    • Ascierto, P. A. et al. Overall survival (OS) and safety results from a phase 3 trial of ipilimumab (IPI) at 3 mg/kg versus 10 mg/kg in patients with metastatic melanoma (MEL). Ann. Oncol. 27 (Suppl. 6), abstr.1106O (2016).
    • (2016) Ann. Oncol. , vol.27
    • Ascierto, P.A.1
  • 80
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • Weber, J. S., Kahler, K. C., Hauschild, A. Management of immune-related adverse events and kinetics of response with ipilimumab. J. Clin. Oncol. 30, 2691-2697 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2691-2697
    • Weber, J.S.1    Kahler, K.C.2    Hauschild, A.3
  • 81
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok, J. D. et al. Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria. Clin. Cancer Res. 15, 7412-7420 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1
  • 82
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
    • Schadendorf, D. et al. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J. Clin. Oncol. 33, 1889-1894 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1889-1894
    • Schadendorf, D.1
  • 83
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial
    • Margolin, K. et al. Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial. Lancet Oncol. 13, 459-465 (2012).
    • (2012) Lancet Oncol , vol.13 , pp. 459-465
    • Margolin, K.1
  • 84
    • 84944261579 scopus 로고    scopus 로고
    • Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center
    • Horvat, T. Z. et al. Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center. J. Clin. Oncol. 33, 3193-3198 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 3193-3198
    • Horvat, T.Z.1
  • 85
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid, O. et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369, 134-144 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 134-144
    • Hamid, O.1
  • 86
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian, S. L. et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J. Clin. Oncol. 32, 1020-1030 (2014).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1020-1030
    • Topalian, S.L.1
  • 87
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
    • Ribas, A. et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial. Lancet Oncol. 16, 908-918 (2015).
    • (2015) Lancet Oncol , vol.16 , pp. 908-918
    • Ribas, A.1
  • 88
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
    • Weber, J. S. et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 16, 375-384 (2015).
    • (2015) Lancet Oncol , vol.16 , pp. 375-384
    • Weber, J.S.1
  • 89
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert, C. et al. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 372, 320-330 (2014).
    • (2014) N. Engl. J. Med. , vol.372 , pp. 320-330
    • Robert, C.1
  • 90
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin, J. et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 373, 23-34 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 23-34
    • Larkin, J.1
  • 91
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran, M. A., Montalvo, W., Yagita, H., Allison, J. P. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl Acad. Sci. USA 107, 4275-4280 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 92
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok, J. D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122-133 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 122-133
    • Wolchok, J.D.1
  • 93
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow, M. A. et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 372, 2006-2017 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2006-2017
    • Postow, M.A.1
  • 94
    • 85011542577 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial
    • Hodi, F. S. et al. Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. Lancet Oncol. 17, 1558-1568 (2016).
    • (2016) Lancet Oncol. , vol.17 , pp. 1558-1568
    • Hodi, F.S.1
  • 95
    • 84991110530 scopus 로고    scopus 로고
    • Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): An open-label, randomised, phase 2 trial
    • Weber, J. S. et al. Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): An open-label, randomised, phase 2 trial. Lancet Oncol. 17, 943-955 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 943-955
    • Weber, J.S.1
  • 96
    • 84977142885 scopus 로고    scopus 로고
    • Talimogene laherparepvec for the treatment of advanced melanoma
    • Ott, P. A., Hodi, F. S. Talimogene laherparepvec for the treatment of advanced melanoma. Clin. Cancer Res. 22, 3127-3131 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 3127-3131
    • Ott, P.A.1    Hodi, F.S.2
  • 97
    • 0036813199 scopus 로고    scopus 로고
    • GM-CSF-based cancer vaccines
    • Dranoff, G. GM-CSF-based cancer vaccines. Immunol. Rev. 188, 147-154 (2002).
    • (2002) Immunol. Rev. , vol.188 , pp. 147-154
    • Dranoff, G.1
  • 98
    • 84933586864 scopus 로고    scopus 로고
    • Talimogene laherparepvec improves durable response rate in patients with advanced melanoma
    • Andtbacka, R. H. et al. Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J. Clin. Oncol. 33, 2780-2788 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 2780-2788
    • Andtbacka, R.H.1
  • 99
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
    • Spranger, S. et al. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. Sci. Transl Med. 5, 200ra116 (2013).
    • (2013) Sci. Transl Med. , vol.5 , pp. 116-200
    • Spranger, S.1
  • 100
    • 84936821508 scopus 로고    scopus 로고
    • Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature
    • 3001
    • Ribas, A. et al. Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature. J. Clin. Oncol. 33 (Suppl.), abstr. 3001(2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Ribas, A.1
  • 101
    • 84979599378 scopus 로고    scopus 로고
    • Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma
    • Puzanov, I. et al. Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma. J. Clin. Oncol. 34, 2619-2626 (2016).
    • (2016) J. Clin. Oncol. , vol.34 , pp. 2619-2626
    • Puzanov, I.1
  • 102
    • 84982149173 scopus 로고    scopus 로고
    • Efficacy analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma
    • 9568
    • Long, G. V. et al. Efficacy analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma. J. Clin. Oncol. 34, (Suppl.), abstr. 9568 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Long, G.V.1
  • 103
    • 85011670254 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab for advanced melanoma: Final overall survival analysis of KEYNOTE-006
    • 9504
    • Schachter, J. et al. Pembrolizumab versus ipilimumab for advanced melanoma: Final overall survival analysis of KEYNOTE-006. J. Clin. Oncol. 34 (Suppl.), abstr. 9504 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Schachter, J.1
  • 104
    • 70349609036 scopus 로고    scopus 로고
    • Simultaneous suppression of MITF and BRAF V600E enhanced inhibition of melanoma cell proliferation
    • Kido, K. et al. Simultaneous suppression of MITF and BRAF V600E enhanced inhibition of melanoma cell proliferation. Cancer Sci. 100, 1863-1869 (2009).
    • (2009) Cancer Sci. , vol.100 , pp. 1863-1869
    • Kido, K.1
  • 105
    • 0030000146 scopus 로고    scopus 로고
    • Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variants in vivo
    • Jager, E. et al. Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: Evidence for immunoselection of antigen-loss variants in vivo. Int. J. Cancer 66, 470-476 (1996).
    • (1996) Int. J. Cancer , vol.66 , pp. 470-476
    • Jager, E.1
  • 106
    • 84889606709 scopus 로고    scopus 로고
    • A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
    • Johannessen, C. M. et al. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Nature 504, 138-142 (2013).
    • (2013) Nature , vol.504 , pp. 138-142
    • Johannessen, C.M.1
  • 107
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick, D. T. et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin. Cancer Res. 19, 1225-1231 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1225-1231
    • Frederick, D.T.1
  • 108
    • 84863393623 scopus 로고    scopus 로고
    • Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
    • Wilmott, J. S. et al. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin. Cancer Res. 18, 1386-1394 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1386-1394
    • Wilmott, J.S.1
  • 109
    • 84961621847 scopus 로고    scopus 로고
    • Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma
    • Cooper, Z. A. et al. Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma. Oncoimmunology 5, e1136044 (2016).
    • (2016) Oncoimmunology , vol.5 , pp. e1136044
    • Cooper, Z.A.1
  • 110
    • 84925262623 scopus 로고    scopus 로고
    • Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAFV600E melanoma
    • Hu-Lieskovan, S. et al. Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAFV600E melanoma. Sci. Transl Med. 7, 279ra41 (2015).
    • (2015) Sci. Transl Med. , vol.7 , pp. 279-341
    • Hu-Lieskovan, S.1
  • 111
    • 84927594692 scopus 로고    scopus 로고
    • BRAF inhibition stimulates melanoma-associated macrophages to drive tumor growth
    • Wang, T. et al. BRAF inhibition stimulates melanoma-associated macrophages to drive tumor growth. Clin. Cancer Res. 21, 1652-1664 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1652-1664
    • Wang, T.1
  • 112
    • 84936821507 scopus 로고    scopus 로고
    • Phase I study combining anti-PD-L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma
    • 3003
    • Ribas, A. et al. Phase I study combining anti-PD-L1 (MEDI4736) with BRAF (dabrafenib) and/or MEK (trametinib) inhibitors in advanced melanoma. J. Clin. Oncol. 33 (Suppl.), abstr. 3003 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Ribas, A.1
  • 113
    • 85084273420 scopus 로고    scopus 로고
    • Preliminary safety and clinical activity of atezolizumab combined with cobimetinib and vemurafenib in BRAF V600-mutant metastatic melanoma
    • 1109PD
    • Hwu, P. et al. Preliminary safety and clinical activity of atezolizumab combined with cobimetinib and vemurafenib in BRAF V600-mutant metastatic melanoma. Ann. Oncol. 27 (Suppl. 6), abstr.1109PD (2016).
    • (2016) Ann. Oncol. , vol.27
    • Hwu, P.1
  • 114
    • 84982152011 scopus 로고    scopus 로고
    • Pembrolizumab (pembro) in combination with dabrafenib (D) and trametinib (T) for BRAF-mutant advanced melanoma: Phase 1 KEYNOTE-022 study
    • 3014
    • Ribas, A. et al. Pembrolizumab (pembro) in combination with dabrafenib (D) and trametinib (T) for BRAF-mutant advanced melanoma: Phase 1 KEYNOTE-022 study. J. Clin. Oncol. 34 (Suppl.), abstr. 3014 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Ribas, A.1
  • 115
    • 84983103421 scopus 로고    scopus 로고
    • Targeting oncogenic BRAF and aberrant MAPK activation in the treatment of cutaneous melanoma
    • Carlino, M. S., Long, G. V., Kefford, R. F., Rizos, H. Targeting oncogenic BRAF and aberrant MAPK activation in the treatment of cutaneous melanoma. Crit. Rev. Oncol. Hematol. 96, 385-398 (2015).
    • (2015) Crit. Rev. Oncol. Hematol. , vol.96 , pp. 385-398
    • Carlino, M.S.1    Long, G.V.2    Kefford, R.F.3    Rizos, H.4
  • 116
    • 84959536816 scopus 로고    scopus 로고
    • Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms
    • Johnson, D. B. et al. Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms. Eur. J. Cancer 51, 2792-2799 (2015).
    • (2015) Eur. J. Cancer , vol.51 , pp. 2792-2799
    • Johnson, D.B.1
  • 117
    • 84891894051 scopus 로고    scopus 로고
    • The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
    • Van Allen, E. M. et al. The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. Cancer Discov. 4, 94-109 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 94-109
    • Van Allen, E.M.1
  • 118
    • 84898738821 scopus 로고    scopus 로고
    • BRAF inhibitor resistance mechanisms in metastatic melanoma: Spectrum and clinical impact
    • Rizos, H. et al. BRAF inhibitor resistance mechanisms in metastatic melanoma: Spectrum and clinical impact. Clin. Cancer Res. 20, 1965-1977 (2014).
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1965-1977
    • Rizos, H.1
  • 119
    • 84923341318 scopus 로고    scopus 로고
    • Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma
    • Long, G. V. et al. Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma. Nat. Commun. 5, 5694 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5694
    • Long, G.V.1
  • 120
    • 84891899026 scopus 로고    scopus 로고
    • MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition
    • Wagle, N. et al. MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition. Cancer Discov. 4, 61-68 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 61-68
    • Wagle, N.1
  • 121
    • 84941350733 scopus 로고    scopus 로고
    • Non-genomic and immune evolution of melanoma acquiring MAPKi resistance
    • Hugo, W. et al. Non-genomic and immune evolution of melanoma acquiring MAPKi resistance. Cell 162, 1271-1285 (2015).
    • (2015) Cell , vol.162 , pp. 1271-1285
    • Hugo, W.1
  • 122
    • 84951757209 scopus 로고    scopus 로고
    • Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma
    • Gray, E. S. et al. Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget 6, 42008-42018 (2015).
    • (2015) Oncotarget , vol.6 , pp. 42008-42018
    • Gray, E.S.1
  • 123
    • 84899974076 scopus 로고    scopus 로고
    • Isolation and molecular characterization of circulating melanoma cells
    • Luo, X. et al. Isolation and molecular characterization of circulating melanoma cells. Cell Rep. 7, 645-653 (2014).
    • (2014) Cell Rep , vol.7 , pp. 645-653
    • Luo, X.1
  • 124
    • 84958978046 scopus 로고    scopus 로고
    • Correlation of BRAF mutation status in circulating-free DNA and tumor and association with clinical outcome across four BRAFi and MEKi clinical trials
    • Santiago-Walker, A. et al. Correlation of BRAF mutation status in circulating-free DNA and tumor and association with clinical outcome across four BRAFi and MEKi clinical trials. Clin. Cancer Res. 22, 567-574 (2016).
    • (2016) Clin. Cancer Res. , vol.22 , pp. 567-574
    • Santiago-Walker, A.1
  • 125
    • 84897933246 scopus 로고    scopus 로고
    • Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis
    • Parmenter, T. J. et al. Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discov. 4, 423-433 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 423-433
    • Parmenter, T.J.1
  • 126
    • 84918582539 scopus 로고    scopus 로고
    • Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1alpha and oxidative phosphorylation in melanoma
    • Gopal, Y. N. et al. Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1alpha and oxidative phosphorylation in melanoma. Cancer Res. 74, 7037-7047 (2014).
    • (2014) Cancer Res , vol.74 , pp. 7037-7047
    • Gopal, Y.N.1
  • 127
    • 84923957819 scopus 로고    scopus 로고
    • The Hippo effector YAP promotes resistance to RAF-A nd MEK-targeted cancer therapies
    • Lin, L. et al. The Hippo effector YAP promotes resistance to RAF-A nd MEK-targeted cancer therapies. Nat. Genet. 47, 250-256 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 250-256
    • Lin, L.1
  • 128
    • 84903740769 scopus 로고    scopus 로고
    • Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics
    • Frederick, D. T. et al. Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics. PLoS ONE 9, e101286 (2014).
    • (2014) PLoS ONE , vol.9 , pp. 101286
    • Frederick, D.T.1
  • 129
    • 84883644630 scopus 로고    scopus 로고
    • TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma
    • Corcoran, R. B. et al. TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Sci. Transl Med. 5, 196ra98 (2013).
    • (2013) Sci. Transl Med. , vol.5 , pp. 196-198
    • Corcoran, R.B.1
  • 130
    • 84875019584 scopus 로고    scopus 로고
    • BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition
    • Haq, R. et al. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc. Natl Acad. Sci. USA 110, 4321-4326 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4321-4326
    • Haq, R.1
  • 131
    • 84876436850 scopus 로고    scopus 로고
    • Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF
    • Haq, R. et al. Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF. Cancer Cell 23, 302-315 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 302-315
    • Haq, R.1
  • 132
    • 54249164136 scopus 로고    scopus 로고
    • Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells
    • Goodall, J. et al. Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. Cancer Res. 68, 7788-7794 (2008).
    • (2008) Cancer Res , vol.68 , pp. 7788-7794
    • Goodall, J.1
  • 133
    • 84904070924 scopus 로고    scopus 로고
    • A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors
    • Konieczkowski, D. J. et al. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discov. 4, 816-827 (2014).
    • (2014) Cancer Discov , vol.4 , pp. 816-827
    • Konieczkowski, D.J.1
  • 134
    • 84923345635 scopus 로고    scopus 로고
    • Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
    • Muller, J. et al. Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma. Nat. Commun. 5, 5712 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5712
    • Muller, J.1
  • 135
    • 84930754781 scopus 로고    scopus 로고
    • Downregulation of the ubiquitin ligase RNF125 underlies resistance of melanoma cells to BRAF inhibitors via JAK1 deregulation
    • Kim, H. et al. Downregulation of the ubiquitin ligase RNF125 underlies resistance of melanoma cells to BRAF inhibitors via JAK1 deregulation. Cell Rep. 11, 1458-1473 (2015).
    • (2015) Cell Rep , vol.11 , pp. 1458-1473
    • Kim, H.1
  • 136
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh, P. C. et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515, 568-571 (2014).
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1
  • 137
    • 77958012775 scopus 로고    scopus 로고
    • Gene signature in melanoma associated with clinical activity: A potential clue to unlock cancer immunotherapy
    • Gajewski, T. F., Louahed, J., Brichard, V. G. Gene signature in melanoma associated with clinical activity: A potential clue to unlock cancer immunotherapy. Cancer J. 16, 399-403 (2010).
    • (2010) Cancer J. , vol.16 , pp. 399-403
    • Gajewski, T.F.1    Louahed, J.2    Brichard, V.G.3
  • 138
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski, T. F., Schreiber, H., Fu, Y. X. Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14, 1014-1022 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 139
    • 66149156276 scopus 로고    scopus 로고
    • Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment
    • Harlin, H. et al. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res. 69, 3077-3085 (2009).
    • (2009) Cancer Res , vol.69 , pp. 3077-3085
    • Harlin, H.1
  • 140
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • Ji, R. R. et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol. Immunother. 61, 1019-1031 (2011).
    • (2011) Cancer Immunol. Immunother. , vol.61 , pp. 1019-1031
    • Ji, R.R.1
  • 141
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian, S. L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 142
    • 84941108977 scopus 로고    scopus 로고
    • Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients
    • 6017
    • Seiwert, T. Y. et al. Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients. J. Clin. Oncol. 33 (Suppl.), abstr. 6017 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Seiwert, T.Y.1
  • 143
    • 84947267135 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) for advanced urothelial cancer: Updated results and biomarker analysis from KEYNOTE-012
    • 4502
    • Plimack, E. R. et al. Pembrolizumab (MK-3475) for advanced urothelial cancer: Updated results and biomarker analysis from KEYNOTE-012. J. Clin. Oncol. 33 (Suppl.), abstr. 4502 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Plimack, E.R.1
  • 144
    • 84977741645 scopus 로고    scopus 로고
    • Correlation of gene expression signatures and clinical outcomes in patients with advanced gastric cancer treated with pembrolizumab (MK-3475
    • 3026
    • Shankaran, V. et al. Correlation of gene expression signatures and clinical outcomes in patients with advanced gastric cancer treated with pembrolizumab (MK-3475). J. Clin. Oncol. 33 (Suppl.), abstr. 3026 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Shankaran, V.1
  • 145
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic-catenin signalling prevents anti-tumour immunity
    • Spranger, S., Bao, R., Gajewski, T. F. Melanoma-intrinsic-catenin signalling prevents anti-tumour immunity. Nature 523, 231-235 (2015).
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 146
    • 84957093642 scopus 로고    scopus 로고
    • Loss of PTEN promotes resistance to T cell-mediated immunotherapy
    • Peng, W. et al. Loss of PTEN promotes resistance to T cell-mediated immunotherapy. Cancer Discov. 6, 202-216 (2016).
    • (2016) Cancer Discov , vol.6 , pp. 202-216
    • Peng, W.1
  • 147
    • 84983216790 scopus 로고    scopus 로고
    • Mutations associated with acquired resistance to PD-1 blockade in melanoma
    • Zaretsky, J. M. et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N. Engl. J. Med. 375, 819-829 (2016).
    • (2016) N. Engl. J. Med. , vol.375 , pp. 819-829
    • Zaretsky, J.M.1
  • 148
    • 85011827059 scopus 로고    scopus 로고
    • Primary resistance to PD-1 blockade mediated by JAK1/2 mutations
    • Shin, D. S. et al. Primary resistance to PD-1 blockade mediated by JAK1/2 mutations. Cancer Discov. 7, 188-201 (2017).
    • (2017) Cancer Discov , vol.7 , pp. 188-201
    • Shin, D.S.1
  • 149
    • 84977472495 scopus 로고    scopus 로고
    • Progression-free survival landmark analysis: A critical endpoint in melanoma clinical trials
    • Ascierto, P. A., Long, G. V. Progression-free survival landmark analysis: A critical endpoint in melanoma clinical trials. Lancet Oncol. 17, 1037-1039 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 1037-1039
    • Ascierto, P.A.1    Long, G.V.2
  • 150
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • Balch, C. M. et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol. 27, 6199-6206 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 6199-6206
    • Balch, C.M.1
  • 151
    • 85025441601 scopus 로고    scopus 로고
    • Baseline and postbaseline characteristics associated with treatment benefit across dabrafenib and trametinib registration pooled data [abstract]
    • Long, G. V. et al. Baseline and postbaseline characteristics associated with treatment benefit across dabrafenib and trametinib registration pooled data [abstract]. Pigment Cell Melanoma Res. 28, 793 (2015).
    • (2015) Pigment Cell Melanoma Res , vol.28 , pp. 793
    • Long, G.V.1
  • 152
    • 84922086584 scopus 로고    scopus 로고
    • Baseline tumor size as an independent prognostic factor for overall survival in patients with metastatic melanoma treated with the anti-PD-1 monoclonal antibody MK-3475
    • 3015
    • Joseph, R. et al. Baseline tumor size as an independent prognostic factor for overall survival in patients with metastatic melanoma treated with the anti-PD-1 monoclonal antibody MK-3475. J. Clin. Oncol. 32 (Suppl.), abstr. 3015 (2014).
    • (2014) J. Clin. Oncol. , vol.32
    • Joseph, R.1
  • 153
    • 85015137315 scopus 로고    scopus 로고
    • Efficacy and safety in key patient subgroups of nivolumab (NIVO) alone or combined with ipilimumab (IPI) versus IPI alone in treatment-nave patients with advanced melanoma (MEL) (CheckMate 067) [abstract 3303]
    • Larkin, J. et al. Efficacy and safety in key patient subgroups of nivolumab (NIVO) alone or combined with ipilimumab (IPI) versus IPI alone in treatment-nave patients with advanced melanoma (MEL) (CheckMate 067) [abstract 3303]. Eur. J. Cancer 51 (Suppl. 3), S664-S665 (2015).
    • (2015) Eur. J. Cancer , vol.51 , pp. S664-S665
    • Larkin, J.1
  • 154
    • 84995462969 scopus 로고    scopus 로고
    • Three-year overall survival for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001
    • 9503
    • Robert, C. et al. Three-year overall survival for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001. J. Clin. Oncol. 34 (Suppl.), abstr. 9503 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Robert, C.1
  • 155
    • 85003637289 scopus 로고    scopus 로고
    • Three-year estimate of overall survival in COMBI-v a randomized phase 3 study evaluating first-line dabrafenib (D) + trametinib (T) in patients (pts) with unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma
    • LBA40
    • Robert, C. et al. Three-year estimate of overall survival in COMBI-v, a randomized phase 3 study evaluating first-line dabrafenib (D) + trametinib (T) in patients (pts) with unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma. J. Clin. Oncol. 27 (Suppl. 6), abstr. LBA40 (2016).
    • (2016) J. Clin. Oncol. , vol.27
    • Robert, C.1
  • 156
    • 84994398716 scopus 로고    scopus 로고
    • Genomic analysis and 3-y efficacy and safety update of COMBI-d: A phase 3 study of dabrafenib (D) + trametinib (T) versus D monotherapy in patients (pts) with unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma
    • 9502
    • Flaherty, K. et al. Genomic analysis and 3-y efficacy and safety update of COMBI-d: A phase 3 study of dabrafenib (D) + trametinib (T) versus D monotherapy in patients (pts) with unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma. J. Clin. Oncol. 34 (Suppl.), abstr. 9502 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Flaherty, K.1
  • 157
    • 84929206263 scopus 로고    scopus 로고
    • Lesion-specific patterns of response and progression with anti-PD-1 treatment in metastatic melanoma (MM
    • 9077
    • Lyle, M. K. et al. Lesion-specific patterns of response and progression with anti-PD-1 treatment in metastatic melanoma (MM). J. Clin. Oncol. 32 (5s Suppl.), abstr. 9077 (2015).
    • (2015) J. Clin. Oncol. , vol.32 , Issue.5
    • Lyle, M.K.1
  • 158
    • 85003534271 scopus 로고    scopus 로고
    • Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment: A pooled analysis of individual patient data from randomised trials
    • Long, G. V. et al. Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment: A pooled analysis of individual patient data from randomised trials. Lancet Oncol. 17, 1743-1754 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 1743-1754
    • Long, G.V.1
  • 159
    • 85025470950 scopus 로고    scopus 로고
    • Update on overall survival (os) and follow-on therapies in BREAK-3 a phase III randomized trial: Dabrafenib (D) versus dacarbazine (DTIC) in patients (pts) with BRAF V600E mutation-positive metastatic melanoma MM) [abstract 1092PD]
    • Hauschild, A. et al. Update on overall survival (os) and follow-on therapies in BREAK-3, a phase III, randomized trial: Dabrafenib (D) versus dacarbazine (DTIC) in patients (pts) with BRAF V600E mutation-positive metastatic melanoma (MM) [abstract 1092PD]. Ann. Oncol.25, iv378 (2014).
    • (2014) Ann. Oncol. , vol.25 , pp. 4378
    • Hauschild, A.1
  • 160
    • 84946508118 scopus 로고    scopus 로고
    • Updated overall survival (OS) results for BRF113220, a phase I-II study of dabrafenib alone versus combined dabrafenib and trametinib in patients with BRAF V600 metastatic melanoma (MM
    • 9036
    • Daud, A. et al. Updated overall survival (OS) results for BRF113220, a phase I-II study of dabrafenib alone versus combined dabrafenib and trametinib in patients with BRAF V600 metastatic melanoma (MM). J. Clin. Oncol. 33 (Suppl.), abstr. 9036 (2015).
    • (2015) J. Clin. Oncol. , vol.33
    • Daud, A.1
  • 161
    • 84868120907 scopus 로고    scopus 로고
    • Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, phase 2 trial
    • Long, G. V. et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, phase 2 trial. Lancet Oncol. 13, 1087-1095 (2012).
    • (2012) Lancet Oncol. , vol.13 , pp. 1087-1095
    • Long, G.V.1
  • 162
    • 84861083983 scopus 로고    scopus 로고
    • Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
    • Falchook, G. S. et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial. Lancet 379, 1893-1901 (2012).
    • (2012) Lancet , vol.379 , pp. 1893-1901
    • Falchook, G.S.1
  • 163
    • 84893661769 scopus 로고    scopus 로고
    • Vemurafenib in patients with BRAFV600 mutation-positive melanoma with symptomatic brain metastases: Final results of an open-label pilot study
    • Dummer, R. et al. Vemurafenib in patients with BRAFV600 mutation-positive melanoma with symptomatic brain metastases: Final results of an open-label pilot study. Eur. J. Cancer 50, 611-621 (2014).
    • (2014) Eur. J. Cancer , vol.50 , pp. 611-621
    • Dummer, R.1
  • 164
    • 85025450451 scopus 로고    scopus 로고
    • Circulating tumor DNA (ctDNA) to track responses and to capture the genomic heterogeneity of metastatic melanoma
    • 9582
    • Sandhu, S. et al. Circulating tumor DNA (ctDNA) to track responses and to capture the genomic heterogeneity of metastatic melanoma. J. Clin. Oncol. 34 (Suppl.), abstr. 9582 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Sandhu, S.1
  • 165
    • 84901340078 scopus 로고    scopus 로고
    • Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors
    • Ackerman, A. et al. Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors. Cancer 120, 1695-1701 (2014).
    • (2014) Cancer , vol.120 , pp. 1695-1701
    • Ackerman, A.1
  • 166
    • 84898729758 scopus 로고    scopus 로고
    • Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: Data from the Italian cohort of the ipilimumab expanded access program
    • Ascierto, P. A. et al. Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: Data from the Italian cohort of the ipilimumab expanded access program. Cancer Invest. 32, 144-149 (2014).
    • (2014) Cancer Invest , vol.32 , pp. 144-149
    • Ascierto, P.A.1
  • 167
    • 84961221351 scopus 로고    scopus 로고
    • Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
    • Hugo, W. et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 165, 35-44 (2016).
    • (2016) Cell , vol.165 , pp. 35-44
    • Hugo, W.1
  • 168
    • 84941800472 scopus 로고    scopus 로고
    • Adaptive immune resistance: How cancer protects from immune attack
    • Ribas, A. Adaptive immune resistance: How cancer protects from immune attack. Cancer Discov. 5, 915-919 (2015).
    • (2015) Cancer Discov , vol.5 , pp. 915-919
    • Ribas, A.1
  • 169
    • 84990177918 scopus 로고    scopus 로고
    • Pembrolizumab (pembro) plus ipilimumab (ipi) for advanced melanoma: Results of the KEYNOTE-029 expansion cohort
    • 9506
    • Long, G. V. et al. Pembrolizumab (pembro) plus ipilimumab (ipi) for advanced melanoma: Results of the KEYNOTE-029 expansion cohort. J. Clin. Oncol. 34 (Suppl.), abstr. 9506 (2016).
    • (2016) J. Clin. Oncol. , vol.34
    • Long, G.V.1
  • 170
    • 84995684655 scopus 로고    scopus 로고
    • Preliminary results from a Phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers [abstract]
    • Gangadhar, T. C. et al. Preliminary results from a Phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers [abstract]. J. Immunother. Cancer 3 (Suppl. 2), O7 (2015).
    • (2015) J. Immunother. Cancer , vol.3 , pp. 07
    • Gangadhar, T.C.1
  • 171
    • 84971619894 scopus 로고    scopus 로고
    • Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: Early analysis of a non-randomised, open-label, phase 2 trial
    • Goldberg, S. B. et al. Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: Early analysis of a non-randomised, open-label, phase 2 trial. Lancet Oncol. 17, 976-983 (2016).
    • (2016) Lancet Oncol , vol.17 , pp. 976-983
    • Goldberg, S.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.