IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment

Cell

Volumn 170, Issue 1, 2017, Pages 127-141.e15

  Nirschl, Christopher J ^a   Suárez Fariñas, Mayte ^b   Izar, Benjamin ^a,c,d   Prakadan, Sanjay ^c,e,f   Dannenfelser, Ruth ^g,h   Tirosh, Itay ^c   Liu, Yong ^a   Zhu, Qian ^g,h   Devi, K Sanjana P ^a   Carroll, Shaina L ^c,e,f   Chau, David ^a   Rezaee, Melika ⁱ   Kim, Tae Gyun ^a   Huang, Ruiqi ^b   Fuentes Duculan, Judilyn ^j   Song Zhao, George X ^a   Gulati, Nicholas ^j   Lowes, Michelle A ^j   King, Sandra L ^a   Quintana, Francisco J ^c,k   Lee, Young suk ^g,h   Krueger, James G ^j   Sarin, Kavita Y ⁱ   Yoon, Charles H ^a,k   Garraway, Levi ^a,c,d,l,m   Regev, Aviv ^c,f,m   Shalek, Alex K ^a,c,e,f,n   Troyanskaya, Olga ^g,h,o   Anandasabapathy, Niroshana ^a,d,p   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e Massachusetts Institute of Technology Cambridge   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^g Princeton University   (United States)

^h PRINCETON UNIVERSITY   (United States)

ⁱ STANFORD UNIVERSITY   (United States)

^j ROCKEFELLER UNIVERSITY   (United States)

^k BRIGHAM AND WOMEN S HOSPITAL   (United States)

^l HARVARD UNIVERSITY   (United States)

^m HOWARD HUGHES MEDICAL INSTITUTE   (United States)

ⁿ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^o Simons Center for Data Analysis   (United States)

^p HARVARD STEM CELL INSTITUTE   (United States)

more..

Author keywords

dendritic cells; differentiation; homeostasis; IFN ; immunotherapy; melanoma; suppressor of cytokine signaling 2 (SOCS2); tissue mononuclear phagocytes; tolerance; tumor microenvironment

Indexed keywords

GAMMA INTERFERON; SUPPRESSOR OF CYTOKINE SIGNALING 2; IFNG PROTEIN, HUMAN; SOCS2 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING; TRANSCRIPTOME;

ADAPTIVE IMMUNITY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENETIC CONSERVATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; METASTATIC MELANOMA; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; SINGLE CELL ANALYSIS; STEADY STATE; TUMOR MICROENVIRONMENT; ANIMAL; DENDRITIC CELL; GENETICS; IMMUNOLOGY; MELANOMA; METABOLISM; METASTASIS; MONOCYTE; PATHOLOGY; SEQUENCE ANALYSIS; SKIN TUMOR;

ANIMALS; CELL DIFFERENTIATION; DENDRITIC CELLS; HOMEOSTASIS; HUMANS; INTERFERON-GAMMA; MELANOMA; MICE; MONOCYTES; NEOPLASM METASTASIS; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; SKIN NEOPLASMS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTOME; TUMOR MICROENVIRONMENT;

EID: 85021662906     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.06.016     Document Type: Article

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