메뉴 건너뛰기




Volumn 62, Issue 5, 2013, Pages 941-948

FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs

Author keywords

Anti CD40; Cancer therapy; CIMT 2012; Immunomodulatory; Isotype

Indexed keywords

ALEMTUZUMAB; BMS 936959; CD27 ANTIBODY; CD40 ANTIBODY; CP 870893; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DROZITUMAB; FAS ANTIGEN; FC RECEPTOR IIB; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MONOCLONAL ANTIBODY; NIVOLUMAB; OX40 ANTIBODY; PD1 ANTIBODY; RITUXIMAB; TUMOR NECROSIS FACTOR RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

EID: 84877822833     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1398-6     Document Type: Review
Times cited : (35)

References (58)
  • 1
    • 66849135251 scopus 로고    scopus 로고
    • Cancer immunotherapy: Co-stimulatory agonists and co-inhibitory antagonists
    • 10.1111/j.1365-2249.2009.03912.x 19659765 10.1111/j.1365-2249.2009.03912. x 1:CAS:528:DC%2BD1MXos1Ojtbo%3D
    • Peggs KS, Quezada SA, Allison JP (2009) Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists. Clin Exp Immunol 157(1):9-19. doi: 10.1111/j.1365-2249.2009.03912.x
    • (2009) Clin Exp Immunol , vol.157 , Issue.1 , pp. 9-19
    • Peggs, K.S.1    Quezada, S.A.2    Allison, J.P.3
  • 2
    • 84856867834 scopus 로고    scopus 로고
    • Immunotherapy earns its spot in the ranks of cancer therapy
    • 10.1084/jem.20112275 22330682 10.1084/jem.20112275 1:CAS:528: DC%2BC38Xis1Krsr0%3D
    • Pardoll D, Drake C (2012) Immunotherapy earns its spot in the ranks of cancer therapy. J Exp Med 209(2):201-209. doi: 10.1084/jem.20112275
    • (2012) J Exp Med , vol.209 , Issue.2 , pp. 201-209
    • Pardoll, D.1    Drake, C.2
  • 3
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • 10.1038/nature10673 10.1038/nature10673
    • Mellman I, Coukos G, Dranoff G (2012) Cancer immunotherapy comes of age. Nature 480(7378):480-489. doi: 10.1038/nature10673
    • (2012) Nature , vol.480 , Issue.7378 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 5
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • 10.1056/NEJMoa1003466 20525992 10.1056/NEJMoa1003466 1:CAS:528: DC%2BC3cXhtVCrtrbN
    • Hodi FS, O'Day SJ, McDermott DF et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711-723. doi: 10.1056/NEJMoa1003466
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 6
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • 10.1056/NEJMoa1200690 22658127 10.1056/NEJMoa1200690 1:CAS:528: DC%2BC38XhtV2rs7fN
    • Topalian SL, Hodi FS, Brahmer JR et al (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366(26):2443-2454. doi: 10.1056/NEJMoa1200690
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 7
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • 0.1056/NEJMoa1200694 22658128 10.1056/NEJMoa1200694 1:CAS:528: DC%2BC38XhtV2rsbnJ
    • Brahmer JR, Tykodi SS, Chow LQ et al (2012) Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366(26):2455-2465. doi: 0.1056/NEJMoa1200694
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 8
    • 80053648839 scopus 로고    scopus 로고
    • Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
    • 10.1073/pnas.1110814108 21933959 10.1073/pnas.1110814108 1:CAS:528:DC%2BC3MXhtlWksrbK
    • Yuan J, Adamow M, Ginsberg BA et al (2011) Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proc Natl Acad Sci 108(40):16723-16728. doi: 10.1073/pnas.1110814108
    • (2011) Proc Natl Acad Sci , vol.108 , Issue.40 , pp. 16723-16728
    • Yuan, J.1    Adamow, M.2    Ginsberg, B.A.3
  • 9
    • 73949113479 scopus 로고    scopus 로고
    • Anti-CD20 monoclonal antibodies: Historical and future perspectives
    • 10.3324/haematol.2008.001628 19773256 10.3324/haematol.2008.001628
    • Lim SH, Beers SA, French RR, Johnson PW, Glennie MJ, Cragg MS (2009) Anti-CD20 monoclonal antibodies: historical and future perspectives. Haematologica 95(1):135-143. doi: 10.3324/haematol.2008.001628
    • (2009) Haematologica , vol.95 , Issue.1 , pp. 135-143
    • Lim, S.H.1    Beers, S.A.2    French, R.R.3    Johnson, P.W.4    Glennie, M.J.5    Cragg, M.S.6
  • 10
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • 10.1056/NEJMra043186 17611206 10.1056/NEJMra043186 1:CAS:528: DC%2BD2sXnsVygu7s%3D
    • Hudis CA (2007) Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med 357(1):39-51. doi: 10.1056/NEJMra043186
    • (2007) N Engl J Med , vol.357 , Issue.1 , pp. 39-51
    • Hudis, C.A.1
  • 11
    • 0032589668 scopus 로고    scopus 로고
    • The role of CAMPATH-1 antibodies in the treatment of lymphoid malignancies
    • 10561018 1:CAS:528:DyaK1MXnslGjt74%3D
    • Dyer MJ (1999) The role of CAMPATH-1 antibodies in the treatment of lymphoid malignancies. Semin Oncol 26(5 Suppl 14):52-57
    • (1999) Semin Oncol , vol.26 , Issue.5 SUPPL. 14 , pp. 52-57
    • Dyer, M.J.1
  • 12
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • 10.1038/nri2744 20414205 10.1038/nri2744 1:CAS:528:DC%2BC3cXltV2kurg%3D
    • Weiner LM, Surana R, Wang S (2010) Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat Rev Immunol 10(5):317-327. doi: 10.1038/nri2744
    • (2010) Nat Rev Immunol , vol.10 , Issue.5 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 13
    • 27144457667 scopus 로고    scopus 로고
    • Monoclonal antibody successes in the clinic
    • 10.1038/nbt0905-1073 16151394 10.1038/nbt0905-1073 1:CAS:528: DC%2BD2MXpvVyrs74%3D
    • Reichert JM, Rosensweig CJ, Faden LB, Dewitz MC (2005) Monoclonal antibody successes in the clinic. Nat Biotechnol 23(9):1073-1078. doi: 10.1038/nbt0905-1073
    • (2005) Nat Biotechnol , vol.23 , Issue.9 , pp. 1073-1078
    • Reichert, J.M.1    Rosensweig, C.J.2    Faden, L.B.3    Dewitz, M.C.4
  • 14
    • 84862245287 scopus 로고    scopus 로고
    • Translating basic mechanisms of IgG effector activity into next generation cancer therapies
    • 22896758
    • Nimmerjahn F, Ravetch JV (2012) Translating basic mechanisms of IgG effector activity into next generation cancer therapies. Cancer Immun 12:13-19
    • (2012) Cancer Immun , vol.12 , pp. 13-19
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 15
    • 37549036732 scopus 로고    scopus 로고
    • Fcgamma receptors as regulators of immune responses
    • 10.1038/nri2206 18064051 10.1038/nri2206 1:CAS:528:DC%2BD2sXhsVKrsLnK
    • Nimmerjahn F, Ravetch JV (2008) Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8(1):34-47. doi: 10.1038/nri2206
    • (2008) Nat Rev Immunol , vol.8 , Issue.1 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 16
    • 3042592452 scopus 로고    scopus 로고
    • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
    • 10.1084/jem.20040119 15210744 10.1084/jem.20040119 1:CAS:528: DC%2BD2cXltFKlurs%3D
    • Uchida J, Hamaguchi Y, Oliver JA, Ravetch JV, Poe JC, Haas KM, Tedder TF (2004) The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med 199(12):1659-1669. doi: 10.1084/jem.20040119
    • (2004) J Exp Med , vol.199 , Issue.12 , pp. 1659-1669
    • Uchida, J.1    Hamaguchi, Y.2    Oliver, J.A.3    Ravetch, J.V.4    Poe, J.C.5    Haas, K.M.6    Tedder, T.F.7
  • 17
    • 51649123832 scopus 로고    scopus 로고
    • Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV
    • 10.1182/blood-2008-01-135160 18495955 10.1182/blood-2008-01-135160 1:CAS:528:DC%2BD1cXpvVOktrc%3D
    • Minard-Colin V, Xiu Y, Poe JC, Horikawa M, Magro CM, Hamaguchi Y, Haas KM, Tedder TF (2008) Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood 112(4):1205-1213. doi: 10.1182/blood-2008-01-135160
    • (2008) Blood , vol.112 , Issue.4 , pp. 1205-1213
    • Minard-Colin, V.1    Xiu, Y.2    Poe, J.C.3    Horikawa, M.4    Magro, C.M.5    Hamaguchi, Y.6    Haas, K.M.7    Tedder, T.F.8
  • 18
    • 77954679392 scopus 로고    scopus 로고
    • Antigenic modulation limits the efficacy of anti-CD20 antibodies: Implications for antibody selection
    • 10.1182/blood-2010-01-263533 20223920 10.1182/blood-2010-01-263533 1:CAS:528:DC%2BC3cXovVWltLw%3D
    • Beers SA, French RR, Chan HT et al (2010) Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Blood 115(25):5191-5201. doi: 10.1182/blood-2010-01-263533
    • (2010) Blood , vol.115 , Issue.25 , pp. 5191-5201
    • Beers, S.A.1    French, R.R.2    Chan, H.T.3
  • 19
    • 33645053518 scopus 로고    scopus 로고
    • Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy
    • 10.1084/jem.20052283 16520392 10.1084/jem.20052283 1:CAS:528: DC%2BD28XjsVSqurY%3D
    • Hamaguchi Y, Xiu Y, Komura K, Nimmerjahn F, Tedder TF (2006) Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 203(3):743-753. doi: 10.1084/jem.20052283
    • (2006) J Exp Med , vol.203 , Issue.3 , pp. 743-753
    • Hamaguchi, Y.1    Xiu, Y.2    Komura, K.3    Nimmerjahn, F.4    Tedder, T.F.5
  • 20
    • 28544449847 scopus 로고    scopus 로고
    • Divergent immunoglobulin g subclass activity through selective Fc receptor binding
    • 10.1126/science.1118948 16322460 10.1126/science.1118948 1:CAS:528:DC%2BD2MXht1GqsrjM
    • Nimmerjahn F, Ravetch JV (2005) Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science 310(5753):1510-1512. doi: 10.1126/science.1118948
    • (2005) Science , vol.310 , Issue.5753 , pp. 1510-1512
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 21
    • 0036464719 scopus 로고    scopus 로고
    • Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene
    • 11806974 10.1182/blood.V99.3.754 1:CAS:528:DC%2BD38XhtVals7k%3D
    • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, Watier H (2002) Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood 99(3):754-758
    • (2002) Blood , vol.99 , Issue.3 , pp. 754-758
    • Cartron, G.1    Dacheux, L.2    Salles, G.3    Solal-Celigny, P.4    Bardos, P.5    Colombat, P.6    Watier, H.7
  • 22
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • 10.1200/JCO.2003.05.013 12975461 10.1200/JCO.2003.05.013 1:CAS:528:DC%2BD2cXpsVajsb8%3D
    • Weng WK, Levy R (2003) Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 21(21):3940-3947. doi: 10.1200/JCO.2003.05.013
    • (2003) J Clin Oncol , vol.21 , Issue.21 , pp. 3940-3947
    • Weng, W.K.1    Levy, R.2
  • 23
    • 61449239114 scopus 로고    scopus 로고
    • Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • 10.1200/JCO.2008.18.0463 19164213 10.1200/JCO.2008.18.0463 1:CAS:528:DC%2BD1MXktVCisr8%3D
    • Bibeau F, Lopez-Crapez E, Di Fiore F et al (2009) Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol 27(7):1122-1129. doi: 10.1200/JCO.2008.18.0463
    • (2009) J Clin Oncol , vol.27 , Issue.7 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3
  • 24
    • 42949157368 scopus 로고    scopus 로고
    • Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
    • 10.1200/JCO.2007.14.8957 18347005 10.1200/JCO.2007.14.8957 1:CAS:528:DC%2BD1cXmsFemsLg%3D
    • Musolino A, Naldi N, Bortesi B et al (2008) Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol 26(11):1789-1796. doi: 10.1200/JCO.2007.14.8957
    • (2008) J Clin Oncol , vol.26 , Issue.11 , pp. 1789-1796
    • Musolino, A.1    Naldi, N.2    Bortesi, B.3
  • 25
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • 10.1038/74704 10742152 10.1038/74704 1:CAS:528:DC%2BD3cXisVOru7Y%3D
    • Clynes RA, Towers TL, Presta LG, Ravetch JV (2000) Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 6(4):443-446. doi: 10.1038/74704
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 26
    • 80052533015 scopus 로고    scopus 로고
    • Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
    • 10.1182/blood-2011-01-330357 21768293 10.1182/blood-2011-01-330357
    • Lim SH, Vaughan AT, Ashton-Key M et al (2011) Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy. Blood 118(9):2530-2540. doi: 10.1182/blood-2011-01-330357
    • (2011) Blood , vol.118 , Issue.9 , pp. 2530-2540
    • Lim, S.H.1    Vaughan, A.T.2    Ashton-Key, M.3
  • 27
    • 35748949531 scopus 로고    scopus 로고
    • Optimizing engagement of the immune system by anti-tumor antibodies: An engineer's perspective
    • 10.1016/j.drudis.2007.08.009 17993407 10.1016/j.drudis.2007.08.009 1:CAS:528:DC%2BD2sXht1ylsrbF
    • Desjarlais JR, Lazar GA, Zhukovsky EA, Chu SY (2007) Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective. Drug Discov Today 12(21-22):898-910. doi: 10.1016/j.drudis.2007.08. 009
    • (2007) Drug Discov Today , vol.12 , Issue.21-22 , pp. 898-910
    • Desjarlais, J.R.1    Lazar, G.A.2    Zhukovsky, E.A.3    Chu, S.Y.4
  • 29
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • 10.1146/annurev.immunol.16.1.111 9597126 10.1146/annurev.immunol.16.1.111 1:CAS:528:DyaK1cXislyitLg%3D
    • Grewal IS, Flavell RA (1998) CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 16:111-135. doi: 10.1146/annurev.immunol.16.1.111
    • (1998) Annu Rev Immunol , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 30
    • 3343015039 scopus 로고    scopus 로고
    • The role of the CD40 pathway in the pathogenesis and treatment of cancer
    • 10.1016/j.coph.2004.02.008 15251129 10.1016/j.coph.2004.02.008 1:CAS:528:DC%2BD2cXls1Wgu70%3D
    • Eliopoulos AG, Young LS (2004) The role of the CD40 pathway in the pathogenesis and treatment of cancer. Curr Opin Pharmacol 4(4):360-367. doi: 10.1016/j.coph.2004.02.008
    • (2004) Curr Opin Pharmacol , vol.4 , Issue.4 , pp. 360-367
    • Eliopoulos, A.G.1    Young, L.S.2
  • 31
    • 0032896709 scopus 로고    scopus 로고
    • CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
    • 10.1038/8426 10229232 10.1038/8426 1:CAS:528:DyaK1MXivVKrs7g%3D
    • French RR, Chan HT, Tutt AL, Glennie MJ (1999) CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat Med 5(5):548-553. doi: 10.1038/8426
    • (1999) Nat Med , vol.5 , Issue.5 , pp. 548-553
    • French, R.R.1    Chan, H.T.2    Tutt, A.L.3    Glennie, M.J.4
  • 32
    • 33947223664 scopus 로고    scopus 로고
    • Prospect of targeting the CD40 pathway for cancer therapy
    • 10.1158/1078-0432.CCR-06-1893 17317815 10.1158/1078-0432.CCR-06-1893 1:CAS:528:DC%2BD2sXhvF2hs7c%3D
    • Vonderheide RH (2007) Prospect of targeting the CD40 pathway for cancer therapy. Clin Cancer Res 13(4):1083-1088. doi: 10.1158/1078-0432.CCR-06-1893
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1083-1088
    • Vonderheide, R.H.1
  • 33
    • 0037087379 scopus 로고    scopus 로고
    • T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody
    • 11884438 1:CAS:528:DC%2BD38XitFSktrY%3D
    • Tutt AL, O'Brien L, Hussain A, Crowther GR, French RR, Glennie MJ (2002) T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody. J Immunol 168(6):2720-2728
    • (2002) J Immunol , vol.168 , Issue.6 , pp. 2720-2728
    • Tutt, A.L.1    O'Brien, L.2    Hussain, A.3    Crowther, G.R.4    French, R.R.5    Glennie, M.J.6
  • 35
    • 33947506186 scopus 로고    scopus 로고
    • Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
    • 10.1200/JCO.2006.08.3311 17327609 10.1200/JCO.2006.08.3311 1:CAS:528:DC%2BD2sXjvVKmtLk%3D
    • Vonderheide RH, Flaherty KT, Khalil M et al (2007) Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol 25(7):876-883. doi: 10.1200/JCO.2006.08.3311
    • (2007) J Clin Oncol , vol.25 , Issue.7 , pp. 876-883
    • Vonderheide, R.H.1    Flaherty, K.T.2    Khalil, M.3
  • 36
    • 70349334508 scopus 로고    scopus 로고
    • Phase i study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
    • 10.1200/JCO.2008.21.3017 19636010 10.1200/JCO.2008.21.3017 1:CAS:528:DC%2BD1MXht1WisbnN
    • Advani R, Forero-Torres A, Furman RR et al (2009) Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol 27(26):4371-4377. doi: 10.1200/JCO.2008.21. 3017
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4371-4377
    • Advani, R.1    Forero-Torres, A.2    Furman, R.R.3
  • 37
    • 50949133383 scopus 로고    scopus 로고
    • The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells
    • 10.1182/blood-2007-04-084756 18497318 10.1182/blood-2007-04-084756 1:CAS:528:DC%2BD1cXpsVaisr0%3D
    • Luqman M, Klabunde S, Lin K et al (2008) The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood 112(3):711-720. doi: 10.1182/blood-2007-04-084756
    • (2008) Blood , vol.112 , Issue.3 , pp. 711-720
    • Luqman, M.1    Klabunde, S.2    Lin, K.3
  • 38
    • 22844449094 scopus 로고    scopus 로고
    • Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease
    • 10.1111/j.1365-2036.2005.02526.x 16011669 10.1111/j.1365-2036.2005.02526. x 1:CAS:528:DC%2BD2MXpt1Cjt7g%3D
    • Kasran A, Boon L, Wortel CH et al (2005) Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease. Aliment Pharmacol Ther 22(2):111-122. doi: 10.1111/j.1365-2036. 2005.02526.x
    • (2005) Aliment Pharmacol Ther , vol.22 , Issue.2 , pp. 111-122
    • Kasran, A.1    Boon, L.2    Wortel, C.H.3
  • 39
    • 79955839464 scopus 로고    scopus 로고
    • A cancer research UK phase i study evaluating safety, tolerability, and biological effects of chimeric anti-CD40 monoclonal antibody (MAb), Chi Lob 7/4
    • abstract 2507
    • Johnson PW, Steve NM, Chowdhury F, Dobbyn J, Hall E, Ashton-Key M, Hodges E, Ottensmeier CH, Williams A, Glennie M (2010) A cancer research UK phase I study evaluating safety, tolerability, and biological effects of chimeric anti-CD40 monoclonal antibody (MAb), Chi Lob 7/4. J Clin Oncol 28(Suppl; abstract 2507)
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Johnson, P.W.1    Steve, N.M.2    Chowdhury, F.3    Dobbyn, J.4    Hall, E.5    Ashton-Key, M.6    Hodges, E.7    Ottensmeier, C.H.8    Williams, A.9    Glennie, M.10
  • 40
    • 77952315198 scopus 로고    scopus 로고
    • A phase i multidose study of dacetuzumab (SGN-40; Humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma
    • 10.3324/haematol.2009.008003 20133895 10.3324/haematol.2009.008003 1:CAS:528:DC%2BC3cXht1yrsbzF
    • Hussein M, Berenson JR, Niesvizky R et al (2010) A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma. Haematologica 95(5):845-848. doi: 10.3324/haematol.2009.008003
    • (2010) Haematologica , vol.95 , Issue.5 , pp. 845-848
    • Hussein, M.1    Berenson, J.R.2    Niesvizky, R.3
  • 41
    • 0027985361 scopus 로고
    • Properties of mouse CD40: The role of homotypic adhesion in the activation of B cells via CD40
    • 10.1002/eji.1830241248 7525301 10.1002/eji.1830241121 1:CAS:528:DyaK2cXmvFyks7s%3D
    • Klaus GG, Holman M, Hasbold J (1994) Properties of mouse CD40: the role of homotypic adhesion in the activation of B cells via CD40. Eur J Immunol 24(11):2714-2719. doi: 10.1002/eji.1830241248
    • (1994) Eur J Immunol , vol.24 , Issue.11 , pp. 2714-2719
    • Klaus, G.G.1    Holman, M.2    Hasbold, J.3
  • 42
    • 80051925907 scopus 로고    scopus 로고
    • Interaction with FcgammaRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody
    • 10.4049/jimmunol.1101135 21742972 10.4049/jimmunol.1101135 1:CAS:528:DC%2BC3MXpslOrtLY%3D
    • White AL, Chan HT, Roghanian A et al (2011) Interaction with FcgammaRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody. J Immunol 187(4):1754-1763. doi: 10.4049/jimmunol.1101135
    • (2011) J Immunol , vol.187 , Issue.4 , pp. 1754-1763
    • White, A.L.1    Chan, H.T.2    Roghanian, A.3
  • 43
    • 80051885494 scopus 로고    scopus 로고
    • Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies
    • 10.1126/science.1206954 21852502 10.1126/science.1206954 1:CAS:528:DC%2BC3MXhtVWrtr%2FM
    • Li F, Ravetch JV (2011) Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science 333(6045):1030-1034. doi: 10.1126/science.1206954
    • (2011) Science , vol.333 , Issue.6045 , pp. 1030-1034
    • Li, F.1    Ravetch, J.V.2
  • 44
    • 77951610700 scopus 로고    scopus 로고
    • FcgammaRIIB in autoimmunity and infection: Evolutionary and therapeutic implications
    • 10.1038/nri2762 20414206 10.1038/nri2762 1:CAS:528:DC%2BC3cXltV2ktb8%3D
    • Smith KG, Clatworthy MR (2010) FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol 10(5):328-343. doi: 10.1038/nri2762
    • (2010) Nat Rev Immunol , vol.10 , Issue.5 , pp. 328-343
    • Smith, K.G.1    Clatworthy, M.R.2
  • 45
    • 0043176281 scopus 로고    scopus 로고
    • Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    • 10.1126/science.1087262 12855817 10.1126/science.1087262 1:CAS:528:DC%2BD3sXlvVKnsLs%3D
    • Yamamoto M, Sato S, Hemmi H et al (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301(5633):640-643. doi: 10.1126/science.1087262
    • (2003) Science , vol.301 , Issue.5633 , pp. 640-643
    • Yamamoto, M.1    Sato, S.2    Hemmi, H.3
  • 46
    • 0038446861 scopus 로고    scopus 로고
    • Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: Implications for agonistic antibody-based therapeutics
    • 12847219 1:CAS:528:DC%2BD3sXltFymt74%3D
    • Xu Y, Szalai AJ, Zhou T, Zinn KR, Chaudhuri TR, Li X, Koopman WJ, Kimberly RP (2003) Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics. J Immunol 171(2):562-568
    • (2003) J Immunol , vol.171 , Issue.2 , pp. 562-568
    • Xu, Y.1    Szalai, A.J.2    Zhou, T.3    Zinn, K.R.4    Chaudhuri, T.R.5    Li, X.6    Koopman, W.J.7    Kimberly, R.P.8
  • 47
    • 84863594998 scopus 로고    scopus 로고
    • Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement
    • 10.1073/pnas.1208698109 22723355 10.1073/pnas.1208698109 1:CAS:528:DC%2BC38XhtFCitL%2FI
    • Li F, Ravetch JV (2012) Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement. Proc Natl Acad Sci 109(27):10966-10971. doi: 10.1073/pnas.1208698109
    • (2012) Proc Natl Acad Sci , vol.109 , Issue.27 , pp. 10966-10971
    • Li, F.1    Ravetch, J.V.2
  • 48
    • 78651466506 scopus 로고    scopus 로고
    • An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells
    • 10.1016/j.ccr.2010.11.012 21251615 10.1016/j.ccr.2010.11.012 1:CAS:528:DC%2BC3MXpvVamtA%3D%3D
    • Wilson NS, Yang B, Yang A et al (2011) An Fcgamma receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. Cancer Cell 19(1):101-113. doi: 10.1016/j.ccr.2010.11.012
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 101-113
    • Wilson, N.S.1    Yang, B.2    Yang, A.3
  • 49
    • 22544487815 scopus 로고    scopus 로고
    • FcgammaRIV: A novel FcR with distinct IgG subclass specificity
    • 10.1016/j.immuni.2005.05.010 16039578 10.1016/j.immuni.2005.05.010 1:CAS:528:DC%2BD2MXnsVeltrk%3D
    • Nimmerjahn F, Bruhns P, Horiuchi K, Ravetch JV (2005) FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity 23(1):41-51. doi: 10.1016/j.immuni.2005.05.010
    • (2005) Immunity , vol.23 , Issue.1 , pp. 41-51
    • Nimmerjahn, F.1    Bruhns, P.2    Horiuchi, K.3    Ravetch, J.V.4
  • 50
    • 84863890977 scopus 로고    scopus 로고
    • Design of CD40 agonists and their use in growing B cells for cancer immunotherapy
    • 10(3109/08830185),2012,703272 22804572 10.3109/08830185.2012.703272 1:CAS:528:DC%2BC38XhtVOjsbbL
    • Kornbluth RS, Stempniak M, Stone GW (2012) Design of CD40 agonists and their use in growing B cells for cancer immunotherapy. Int Rev Immunol 31(4):279-288. doi: 10(3109/08830185),2012,703272
    • (2012) Int Rev Immunol , vol.31 , Issue.4 , pp. 279-288
    • Kornbluth, R.S.1    Stempniak, M.2    Stone, G.W.3
  • 51
    • 0035871757 scopus 로고    scopus 로고
    • Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4
    • 11290766 1:CAS:528:DC%2BD3MXivVKnu7o%3D
    • Chuntharapai A, Dodge K, Grimmer K, Schroeder K, Marsters SA, Koeppen H, Ashkenazi A, Kim KJ (2001) Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4. J Immunol 166(8):4891-4898
    • (2001) J Immunol , vol.166 , Issue.8 , pp. 4891-4898
    • Chuntharapai, A.1    Dodge, K.2    Grimmer, K.3    Schroeder, K.4    Marsters, S.A.5    Koeppen, H.6    Ashkenazi, A.7    Kim, K.J.8
  • 52
    • 10744220151 scopus 로고    scopus 로고
    • Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    • 10.1084/jem.20031457 14769851 10.1084/jem.20031457 1:CAS:528: DC%2BD2cXhsFKhuro%3D
    • Takeda K, Yamaguchi N, Akiba H et al (2004) Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy. J Exp Med 199(4):437-448. doi: 10.1084/jem.20031457
    • (2004) J Exp Med , vol.199 , Issue.4 , pp. 437-448
    • Takeda, K.1    Yamaguchi, N.2    Akiba, H.3
  • 53
    • 65549114676 scopus 로고    scopus 로고
    • Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    • 10.1182/blood-2008-09-179754 19018092 10.1182/blood-2008-09-179754 1:CAS:528:DC%2BD1MXlt1yjsL0%3D
    • Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S, Daeron M (2009) Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113(16):3716-3725. doi: 10.1182/blood-2008-09-179754
    • (2009) Blood , vol.113 , Issue.16 , pp. 3716-3725
    • Bruhns, P.1    Iannascoli, B.2    England, P.3    Mancardi, D.A.4    Fernandez, N.5    Jorieux, S.6    Daeron, M.7
  • 54
    • 49449109842 scopus 로고    scopus 로고
    • Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies
    • 10.1016/j.molimm.2008.06.027 18691763 10.1016/j.molimm.2008.06.027 1:CAS:528:DC%2BD1cXhtVaisLjF
    • Chu SY, Vostiar I, Karki S et al (2008) Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies. Mol Immunol 45(15):3926-3933. doi: 10.1016/j.molimm.2008.06.027
    • (2008) Mol Immunol , vol.45 , Issue.15 , pp. 3926-3933
    • Chu, S.Y.1    Vostiar, I.2    Karki, S.3
  • 55
    • 84859991126 scopus 로고    scopus 로고
    • Mouse model recapitulating human Fcgamma receptor structural and functional diversity
    • 10.1073/pnas.1203954109 22474370 10.1073/pnas.1203954109 1:CAS:528:DC%2BC38Xmt12muro%3D
    • Smith P, DiLillo DJ, Bournazos S, Li F, Ravetch JV (2012) Mouse model recapitulating human Fcgamma receptor structural and functional diversity. Proc Natl Acad Sci 109(16):6181-6186. doi: 10.1073/pnas.1203954109
    • (2012) Proc Natl Acad Sci , vol.109 , Issue.16 , pp. 6181-6186
    • Smith, P.1    Dilillo, D.J.2    Bournazos, S.3    Li, F.4    Ravetch, J.V.5
  • 56
    • 0032926595 scopus 로고    scopus 로고
    • Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells
    • 10050669 10.1093/intimm/11.1.11 1:CAS:528:DyaK1MXhtVWgur8%3D
    • Pound JD, Challa A, Holder MJ et al (1999) Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells. Int Immunol 11(1):11-20
    • (1999) Int Immunol , vol.11 , Issue.1 , pp. 11-20
    • Pound, J.D.1    Challa, A.2    Holder, M.J.3
  • 57
    • 0042505740 scopus 로고    scopus 로고
    • Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists
    • 10.1084/jem.20021024 12707299 10.1084/jem.20021024 1:CAS:528: DC%2BD3sXjt1Wlsro%3D
    • Luhder F, Huang Y, Dennehy KM et al (2003) Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. J Exp Med 197(8):955-966. doi: 10.1084/jem.20021024
    • (2003) J Exp Med , vol.197 , Issue.8 , pp. 955-966
    • Luhder, F.1    Huang, Y.2    Dennehy, K.M.3
  • 58
    • 79960497321 scopus 로고    scopus 로고
    • Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies
    • 10.1182/blood-2010-09-305847 21444918 10.1182/blood-2010-09-305847 1:CAS:528:DC%2BC3MXpsVWmtLk%3D
    • Niederfellner G, Lammens A, Mundigl O et al (2011) Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies. Blood 118(2):358-367. doi: 10.1182/blood-2010-09-305847
    • (2011) Blood , vol.118 , Issue.2 , pp. 358-367
    • Niederfellner, G.1    Lammens, A.2    Mundigl, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.