메뉴 건너뛰기




Volumn 3, Issue 2, 2014, Pages

Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy

Author keywords

CD137; Checkpoint blockade; Immunogenic chemotherapy; Immunosuppression; IPH2101; Lirilumab; PD L1

Indexed keywords

9 B 12; 9B12; AMP 224; BMS 936559; CD134 ANTIGEN; CP 870 893; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DACETUZUMAB; FRESOLIMUMAB; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; IMP 321; IPH 2101; IPILIMUMAB; LIRILUMAB; LUCATUMUMAB; MEDI 4736; MEDI 6469; MONOCLONAL ANTIBODY; MPDL 3280 A; MSB 0010718 C; NIVOLUMAB; PEMBROLIZUMAB; PF 05082566; PIDILIZUMAB; PROGRAMMED DEATH 1 RECEPTOR; TICILIMUMAB; TRX 518; UNCLASSIFIED DRUG; UNINDEXED DRUG; URELUMAB; VARLILUMAB;

EID: 84899112560     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.27297     Document Type: Review
Times cited : (103)

References (124)
  • 1
    • 85047696843 scopus 로고    scopus 로고
    • Monoclonal antibodies: the story of a discovery that revolutionized science and medicine
    • PMID:15040588
    • Alkan SS. Monoclonal antibodies: the story of a discovery that revolutionized science and medicine. Nat Rev Immunol 2004; 4:153-6; PMID:15040588; http://dx.doi.org/10.1038/nri1265.
    • (2004) Nat Rev Immunol , vol.4 , pp. 153-156
    • Alkan, S.S.1
  • 2
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: versatile platforms for cancer immunotherapy
    • PMID:20414205
    • Weiner LM, Surana R, Wang S. Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat Rev Immunol 2010; 10:317-27; PMID:20414205; http://dx.doi.org/10.1038/nri2744.
    • (2010) Nat Rev Immunol , vol.10 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 3
    • 84874889330 scopus 로고    scopus 로고
    • Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
    • PMID:23460531
    • Melero I, Grimaldi AM, Perez-Gracia JL, Ascierto PA. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin Cancer Res 2013; 19:997-1008; PMID:23460531; http://dx.doi.org/10.1158/1078-0432.CCR-12-2214.
    • (2013) Clin Cancer Res , vol.19 , pp. 997-1008
    • Melero, I.1    Grimaldi, A.M.2    Perez-Gracia, J.L.3    Ascierto, P.A.4
  • 4
    • 33846465547 scopus 로고    scopus 로고
    • Immunostimulatory monoclonal antibodies for cancer therapy
    • PMID:17251916
    • Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 2007; 7:95-106; PMID:17251916; http://dx.doi.org/10.1038/nrc2051.
    • (2007) Nat Rev Cancer , vol.7 , pp. 95-106
    • Melero, I.1    Hervas-Stubbs, S.2    Glennie, M.3    Pardoll, D.M.4    Chen, L.5
  • 5
    • 33747135818 scopus 로고    scopus 로고
    • Therapeutic potential of immunostimulatory monoclonal antibodies
    • PMID:16831129
    • Gray JC, Johnson PW, Glennie MJ. Therapeutic potential of immunostimulatory monoclonal antibodies. Clin Sci (Lond) 2006; 111:93-106; PMID:16831129; http://dx.doi.org/10.1042/CS20060024.
    • (2006) Clin Sci (Lond) , vol.111 , pp. 93-106
    • Gray, J.C.1    Johnson, P.W.2    Glennie, M.J.3
  • 9
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • PMID:15136787
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3:391-400; PMID:15136787; http://dx.doi.org/10.1038/nrd1381.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 10
    • 84876872556 scopus 로고    scopus 로고
    • Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment
    • PMID:23243624
    • Michielsen AJ, Ryan EJ, O'Sullivan JN. Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment. Oncoimmunology 2012; 1:1445-7; PMID:23243624; http://dx.doi.org/10.4161/onci.21318.
    • (2012) Oncoimmunology , vol.1 , pp. 1445-1447
    • Michielsen, A.J.1    Ryan, E.J.2    O'Sullivan, J.N.3
  • 13
    • 84886943894 scopus 로고    scopus 로고
    • High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicator
    • PMID:22720216
    • Sorbye SW, Kilvaer T, Valkov A, Donnem T, Smeland E, Al-Shibli K, Bremnes RM, Busund LT. High expression of CD20+ lymphocytes in soft tissue sarcomas is a positive prognostic indicator. Oncoimmunology 2012; 1:75-7; PMID:22720216; http://dx.doi.org/10.4161/onci.1.1.17825.
    • (2012) Oncoimmunology , vol.1 , pp. 75-77
    • Sorbye, S.W.1    Kilvaer, T.2    Valkov, A.3    Donnem, T.4    Smeland, E.5    Al-Shibli, K.6    Bremnes, R.M.7    Busund, L.T.8
  • 14
    • 30444461383 scopus 로고    scopus 로고
    • Fcgamma receptors: old friends and new family members
    • PMID:16413920
    • Nimmerjahn F, Ravetch JV. Fcgamma receptors: old friends and new family members. Immunity 2006; 24:19-28; PMID:16413920; http://dx.doi. org/10.1016/j.immuni.2005.11.010.
    • (2006) Immunity , vol.24 , pp. 19-28
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 15
    • 84885366553 scopus 로고    scopus 로고
    • Antibody-dependent cell cytotoxicity in monoclonal antibody-mediated tumor immunotherapy
    • PMID:22720225
    • Hubert P, Amigorena S. Antibody-dependent cell cytotoxicity in monoclonal antibody-mediated tumor immunotherapy. Oncoimmunology 2012; 1:103-5; PMID:22720225; http://dx.doi.org/10.4161/onci.1.1.17963.
    • (2012) Oncoimmunology , vol.1 , pp. 103-105
    • Hubert, P.1    Amigorena, S.2
  • 16
    • 84886944363 scopus 로고    scopus 로고
    • Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody
    • PMID:23162770
    • Houot R, Kohrt H, Levy R. Boosting antibody-dependant cellular cytotoxicity against tumor cells with a CD137 stimulatory antibody. Oncoimmunology 2012; 1:957-8; PMID:23162770; http://dx.doi. org/10.4161/onci.19974.
    • (2012) Oncoimmunology , vol.1 , pp. 957-958
    • Houot, R.1    Kohrt, H.2    Levy, R.3
  • 17
    • 84877135653 scopus 로고    scopus 로고
    • Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells
    • PMID:23162748
    • Kute T, Stehle JR Jr., Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology 2012; 1:810-21; PMID:23162748; http://dx.doi.org/10.4161/onci.20447.
    • (2012) Oncoimmunology , vol.1 , pp. 810-821
    • Kute, T.1    Stehle Jr., J.R.2    Ornelles, D.3    Walker, N.4    Delbono, O.5    Vaughn, J.P.6
  • 18
    • 79955011744 scopus 로고    scopus 로고
    • Molecular mechanisms of the antitumor effects of anti-CD20 antibodies
    • PMID:21196171
    • Winiarska M, Glodkowska-Mrowka E, Bil J, Golab J. Molecular mechanisms of the antitumor effects of anti-CD20 antibodies. Front Biosci (Landmark Ed) 2011; 16:277-306; PMID:21196171; http://dx.doi. org/10.2741/3688.
    • (2011) Front Biosci (Landmark Ed) , vol.16 , pp. 277-306
    • Winiarska, M.1    Glodkowska-Mrowka, E.2    Bil, J.3    Golab, J.4
  • 19
    • 73849090193 scopus 로고    scopus 로고
    • Complement and its role in innate and adaptive immune responses
    • PMID:20010915
    • Dunkelberger JR, Song WC. Complement and its role in innate and adaptive immune responses. Cell Res 2010; 20:34-50; PMID:20010915; http://dx.doi. org/10.1038/cr.2009.139.
    • (2010) Cell Res , vol.20 , pp. 34-50
    • Dunkelberger, J.R.1    Song, W.C.2
  • 20
    • 70349437186 scopus 로고    scopus 로고
    • Complement regulators and inhibitory proteins
    • PMID:19730437
    • Zipfel PF, Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol 2009; 9:729-40; PMID:19730437.
    • (2009) Nat Rev Immunol , vol.9 , pp. 729-740
    • Zipfel, P.F.1    Skerka, C.2
  • 22
    • 84886944943 scopus 로고    scopus 로고
    • TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR(+) head and neck cancer cells
    • PMID:23894722
    • Ming Lim C, Stephenson R, Salazar AM, Ferris RL. TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR(+) head and neck cancer cells. Oncoimmunology 2013; 2:e24677; PMID:23894722; http://dx.doi.org/10.4161/onci.24677.
    • (2013) Oncoimmunology , vol.2
    • Ming Lim, C.1    Stephenson, R.2    Salazar, A.M.3    Ferris, R.L.4
  • 23
    • 33846564399 scopus 로고    scopus 로고
    • Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma
    • PMID:17096332
    • Kawaguchi Y, Kono K, Mimura K, Sugai H, Akaike H, Fujii H. Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma. Int J Cancer 2007; 120:781-7; PMID:17096332; http://dx.doi. org/10.1002/ijc.22370.
    • (2007) Int J Cancer , vol.120 , pp. 781-787
    • Kawaguchi, Y.1    Kono, K.2    Mimura, K.3    Sugai, H.4    Akaike, H.5    Fujii, H.6
  • 24
    • 84877096819 scopus 로고    scopus 로고
    • Cetuximabactivated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients
    • PMID:23444227
    • Srivastava RM, Lee SC, Andrade Filho PA, Lord CA, Jie HB, Davidson HC, López-Albaitero A, Gibson SP, Gooding WE, Ferrone S, et al. Cetuximabactivated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin Cancer Res 2013; 19:1858-72; PMID:23444227; http://dx.doi. org/10.1158/1078-0432.CCR-12-2426.
    • (2013) Clin Cancer Res , vol.19 , pp. 1858-1872
    • Srivastava, R.M.1    Lee, S.C.2    Andrade Filho, P.A.3    Lord, C.A.4    Jie, H.B.5    Davidson, H.C.6    López-Albaitero, A.7    Gibson, S.P.8    Gooding, W.E.9    Ferrone, S.10
  • 25
    • 84857789296 scopus 로고    scopus 로고
    • The secret al.y: immunostimulation by anticancer drugs
    • PMID:22301798
    • Galluzzi L, Senovilla L, Zitvogel L, Kroemer G. The secret al.y: immunostimulation by anticancer drugs. Nat Rev Drug Discov 2012; 11:215-33; PMID:22301798; http://dx.doi.org/10.1038/nrd3626.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 215-233
    • Galluzzi, L.1    Senovilla, L.2    Zitvogel, L.3    Kroemer, G.4
  • 26
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance
    • PMID:23890065
    • Zitvogel L, Galluzzi L, Smyth MJ, Kroemer G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity 2013; 39:74-88; PMID:23890065; http://dx.doi.org/10.1016/j.immuni.2013.06.014.
    • (2013) Immunity , vol.39 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4
  • 27
    • 0037093241 scopus 로고    scopus 로고
    • Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma
    • PMID:12011122
    • Witzig TE, Gordon LI, Cabanillas F, Czuczman MS, Emmanouilides C, Joyce R, Pohlman BL, Bartlett NL, Wiseman GA, Padre N, et al. Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. J Clin Oncol 2002; 20:2453-63; PMID:12011122; http://dx.doi. org/10.1200/JCO.2002.11.076.
    • (2002) J Clin Oncol , vol.20 , pp. 2453-2463
    • Witzig, T.E.1    Gordon, L.I.2    Cabanillas, F.3    Czuczman, M.S.4    Emmanouilides, C.5    Joyce, R.6    Pohlman, B.L.7    Bartlett, N.L.8    Wiseman, G.A.9    Padre, N.10
  • 28
    • 0034662510 scopus 로고    scopus 로고
    • Radioimmunotherapy with iodine (131)I tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma: updated results and long-term follow-up of the University of Michigan experience
    • PMID:10942366
    • Kaminski MS, Estes J, Zasadny KR, Francis IR, Ross CW, Tuck M, Regan D, Fisher S, Gutierrez J, Kroll S, et al. Radioimmunotherapy with iodine (131)I tositumomab for relapsed or refractory B-cell non-Hodgkin lymphoma: updated results and long-term follow-up of the University of Michigan experience. Blood 2000; 96:1259-66; PMID:10942366.
    • (2000) Blood , vol.96 , pp. 1259-1266
    • Kaminski, M.S.1    Estes, J.2    Zasadny, K.R.3    Francis, I.R.4    Ross, C.W.5    Tuck, M.6    Regan, D.7    Fisher, S.8    Gutierrez, J.9    Kroll, S.10
  • 29
    • 82255192901 scopus 로고    scopus 로고
    • The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
    • PMID:22116087
    • Walker LS, Sansom DM. The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat Rev Immunol 2011; 11:852-63; PMID:22116087; http://dx.doi.org/10.1038/nri3108.
    • (2011) Nat Rev Immunol , vol.11 , pp. 852-863
    • Walker, L.S.1    Sansom, D.M.2
  • 30
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • PMID:15122199
    • Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004; 4:336-47; PMID:15122199; http://dx.doi.org/10.1038/nri1349.
    • (2004) Nat Rev Immunol , vol.4 , pp. 336-347
    • Chen, L.1
  • 31
    • 84885714781 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
    • PMID:22754781
    • Waitz R, Fassò M, Allison JP. CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection. Oncoimmunology 2012; 1:544-6; PMID:22754781; http://dx.doi.org/10.4161/onci.19442.
    • (2012) Oncoimmunology , vol.1 , pp. 544-546
    • Waitz, R.1    Fassò, M.2    Allison, J.P.3
  • 32
    • 84886945566 scopus 로고    scopus 로고
    • The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4(+) T cells
    • PMID:23734334
    • Munir S, Andersen GH, Svane IM, Andersen MH. The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4(+) T cells. Oncoimmunology 2013; 2:e23991; PMID:23734334; http://dx.doi.org/10.4161/onci.23991.
    • (2013) Oncoimmunology , vol.2
    • Munir, S.1    Andersen, G.H.2    Svane, I.M.3    Andersen, M.H.4
  • 33
    • 84877896663 scopus 로고    scopus 로고
    • Targeting PD-1/PD-L1 interactions for cancer immunotherapy
    • PMID:23243584
    • Zitvogel L, Kroemer G. Targeting PD-1/PD-L1 interactions for cancer immunotherapy. Oncoimmunology 2012; 1:1223-5; PMID:23243584; http://dx.doi. org/10.4161/onci.21335.
    • (2012) Oncoimmunology , vol.1 , pp. 1223-1225
    • Zitvogel, L.1    Kroemer, G.2
  • 34
    • 70350433514 scopus 로고    scopus 로고
    • Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal
    • PMID:19783989
    • Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol 2009; 10:1185-92; PMID:19783989; http://dx.doi.org/10.1038/ni.1790.
    • (2009) Nat Immunol , vol.10 , pp. 1185-1192
    • Fife, B.T.1    Pauken, K.E.2    Eagar, T.N.3    Obu, T.4    Wu, J.5    Tang, Q.6    Azuma, M.7    Krummel, M.F.8    Bluestone, J.A.9
  • 35
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • PMID:17304234
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 2007; 8:239-45; PMID:17304234; http://dx.doi.org/10.1038/ni1443.
    • (2007) Nat Immunol , vol.8 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 37
    • 68849105814 scopus 로고    scopus 로고
    • Oncogenic stress sensed by the immune system: role of natural killer cell receptors
    • PMID:19629084
    • Raulet DH, Guerra N. Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat Rev Immunol 2009; 9:568-80; PMID:19629084; http://dx.doi.org/10.1038/nri2604.
    • (2009) Nat Rev Immunol , vol.9 , pp. 568-580
    • Raulet, D.H.1    Guerra, N.2
  • 38
    • 0036831613 scopus 로고    scopus 로고
    • New aspects of natural-killer-cell surveillance and therapy of cancer
    • PMID:12415255
    • Smyth MJ, Hayakawa Y, Takeda K, Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2002; 2:850-61; PMID:12415255; http://dx.doi.org/10.1038/nrc928.
    • (2002) Nat Rev Cancer , vol.2 , pp. 850-861
    • Smyth, M.J.1    Hayakawa, Y.2    Takeda, K.3    Yagita, H.4
  • 39
    • 49249089100 scopus 로고    scopus 로고
    • Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells
    • PMID:18759922
    • Joncker NT, Raulet DH. Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells. Immunol Rev 2008; 224:85-97; PMID:18759922; http://dx.doi. org/10.1111/j.1600-065X.2008.00658.x.
    • (2008) Immunol Rev , vol.224 , pp. 85-97
    • Joncker, N.T.1    Raulet, D.H.2
  • 40
    • 49249097006 scopus 로고    scopus 로고
    • Negative signaling by inhibitory receptors: the NK cell paradigm
    • PMID:18759921
    • Long EO. Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev 2008; 224:70-84; PMID:18759921; http://dx.doi. org/10.1111/j.1600-065X.2008.00660.x.
    • (2008) Immunol Rev , vol.224 , pp. 70-84
    • Long, E.O.1
  • 41
    • 80054856205 scopus 로고    scopus 로고
    • OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function
    • PMID:22017436
    • Withers DR, Gaspal FM, Bekiaris V, McConnell FM, Kim M, Anderson G, Lane PJ. OX40 and CD30 signals in CD4(+) T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function. Immunol Rev 2011; 244:134-48; PMID:22017436; http://dx.doi. org/10.1111/j.1600-065X.2011.01057.x.
    • (2011) Immunol Rev , vol.244 , pp. 134-148
    • Withers, D.R.1    Gaspal, F.M.2    Bekiaris, V.3    McConnell, F.M.4    Kim, M.5    Anderson, G.6    Lane, P.J.7
  • 42
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • PMID:19319144
    • Croft M. The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 2009; 9:271-85; PMID:19319144; http://dx.doi. org/10.1038/nri2526.
    • (2009) Nat Rev Immunol , vol.9 , pp. 271-285
    • Croft, M.1
  • 43
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    • PMID:15173831
    • Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol 2004; 4:420-31; PMID:15173831; http://dx.doi.org/10.1038/nri1371.
    • (2004) Nat Rev Immunol , vol.4 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.D.3
  • 44
    • 84886944957 scopus 로고    scopus 로고
    • OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T cells
    • PMID:22754764
    • Hombach AA, Heiders J, Foppe M, Chmielewski M, Abken H. OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T cells. Oncoimmunology 2012; 1:458-66; PMID:22754764; http://dx.doi. org/10.4161/onci.19855.
    • (2012) Oncoimmunology , vol.1 , pp. 458-466
    • Hombach, A.A.1    Heiders, J.2    Foppe, M.3    Chmielewski, M.4    Abken, H.5
  • 45
    • 33746575650 scopus 로고    scopus 로고
    • The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?
    • PMID:16868552
    • Shevach EM, Stephens GL. The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat Rev Immunol 2006; 6:613-8; PMID:16868552; http://dx.doi.org/10.1038/nri1867.
    • (2006) Nat Rev Immunol , vol.6 , pp. 613-618
    • Shevach, E.M.1    Stephens, G.L.2
  • 46
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • PMID:11812990
    • Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002; 3:135-42; PMID:11812990; http://dx.doi.org/10.1038/ni759.
    • (2002) Nat Immunol , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 47
    • 0034960320 scopus 로고    scopus 로고
    • TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
    • PMID:11420042
    • Chen W, Frank ME, Jin W, Wahl SM. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001; 14:715-25; PMID:11420042; http://dx.doi.org/10.1016/S1074-7613(01)00147-9.
    • (2001) Immunity , vol.14 , pp. 715-725
    • Chen, W.1    Frank, M.E.2    Jin, W.3    Wahl, S.M.4
  • 48
    • 84886943543 scopus 로고    scopus 로고
    • Breaking tumor-induced immunosuppression with 5¢-triphosphate siRNA silencing TGFβ and activating RIG-I
    • PMID:23762798
    • Schnurr M, Duewell P. Breaking tumor-induced immunosuppression with 5¢-triphosphate siRNA silencing TGFβ and activating RIG-I. Oncoimmunology 2013; 2:e24170; PMID:23762798; http://dx.doi. org/10.4161/onci.24170.
    • (2013) Oncoimmunology , vol.2
    • Schnurr, M.1    Duewell, P.2
  • 49
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factorbeta in T-cell biology
    • PMID:11905837
    • Gorelik L, Flavell RA. Transforming growth factorbeta in T-cell biology. Nat Rev Immunol 2002; 2:46-53; PMID:11905837; http://dx.doi.org/10.1038/nri704.
    • (2002) Nat Rev Immunol , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 50
    • 84888639681 scopus 로고    scopus 로고
    • The roles of TGFβ in the tumour microenvironment
    • PMID:24132110
    • Pickup M, Novitskiy S, Moses HL. The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer 2013; 13:788-99; PMID:24132110; http://dx.doi.org/10.1038/nrc3603.
    • (2013) Nat Rev Cancer , vol.13 , pp. 788-799
    • Pickup, M.1    Novitskiy, S.2    Moses, H.L.3
  • 51
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: a complex web in cancer progression
    • PMID:20495575
    • Ikushima H, Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer 2010; 10:415-24; PMID:20495575; http://dx.doi. org/10.1038/nrc2853.
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 52
    • 0023753622 scopus 로고
    • Phase I trial of multiple large doses of murine monoclonal antibody CO17-1A. I. Clinical aspects
    • PMID:3398068
    • LoBuglio AF, Saleh MN, Lee J, Khazaeli MB, Carrano R, Holden H, Wheeler RH. Phase I trial of multiple large doses of murine monoclonal antibody CO17-1A. I. Clinical aspects. J Natl Cancer Inst 1988; 80:932-6; PMID:3398068; http://dx.doi. org/10.1093/jnci/80.12.932.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 932-936
    • LoBuglio, A.F.1    Saleh, M.N.2    Lee, J.3    Khazaeli, M.B.4    Carrano, R.5    Holden, H.6    Wheeler, R.H.7
  • 54
    • 0022339520 scopus 로고
    • Phase II clinical trial of a murine monoclonal antibody cytotoxic for gastrointestinal adenocarcinoma
    • PMID:4053061
    • Sears HF, Herlyn D, Steplewski Z, Koprowski H. Phase II clinical trial of a murine monoclonal antibody cytotoxic for gastrointestinal adenocarcinoma. Cancer Res 1985; 45:5910-3; PMID:4053061.
    • (1985) Cancer Res , vol.45 , pp. 5910-5913
    • Sears, H.F.1    Herlyn, D.2    Steplewski, Z.3    Koprowski, H.4
  • 55
    • 0020038963 scopus 로고
    • Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours
    • PMID:6121224
    • Sears HF, Atkinson B, Mattis J, Ernst C, Herlyn D, Steplewski Z, Häyry P, Koprowski H. Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours. Lancet 1982; 1:762-5; PMID:6121224; http://dx.doi.org/10.1016/S0140-6736(82)91811-6.
    • (1982) Lancet , vol.1 , pp. 762-765
    • Sears, H.F.1    Atkinson, B.2    Mattis, J.3    Ernst, C.4    Herlyn, D.5    Steplewski, Z.6    Häyry, P.7    Koprowski, H.8
  • 56
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • PMID:8011301
    • Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994; 12:991-1045; PMID:8011301; http://dx.doi.org/10.1146/annurev. iy.12.040194.005015.
    • (1994) Annu Rev Immunol , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 57
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: a renewed sense of self
    • PMID:11951032
    • Matzinger P. The danger model: a renewed sense of self. Science 2002; 296:301-5; PMID:11951032; http://dx.doi.org/10.1126/science.1071059.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 60
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study
    • PMID:20004617
    • Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, Waterfield W, Schadendorf D, Smylie M, Guthrie T Jr., et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 2010; 11:155-64; PMID:20004617; http://dx.doi.org/10.1016/S1470-2045(09)70334-1.
    • (2010) Lancet Oncol , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3    Negrier, S.4    Lutzky, J.5    Thomas, L.6    Waterfield, W.7    Schadendorf, D.8    Smylie, M.9    Guthrie Jr., T.10
  • 61
    • 84877726569 scopus 로고    scopus 로고
    • Clinical activity and safety of anti-programmed death-1 (PD-1) (BMS-936558/MDX-1106/ONO-4538) in patients (pts) with advanced melanoma (mel)
    • Sosman J, Sznol M, McDermott D, Carvajal RD, Lawrence DP, Topalian SL, et al. Clinical activity and safety of anti-programmed death-1 (PD-1) (BMS-936558/MDX-1106/ONO-4538) in patients (pts) with advanced melanoma (mel). Ann Oncol 2012; 23: ix367-75.
    • (2012) Ann Oncol , vol.23 , pp. 9367-9375
    • Sosman, J.1    Sznol, M.2    McDermott, D.3    Carvajal, R.D.4    Lawrence, D.P.5    Topalian, S.L.6
  • 62
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • PMID:20516446
    • Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010; 28:3167-75; PMID:20516446; http://dx.doi. org/10.1200/JCO.2009.26.7609.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3    Powderly, J.D.4    Picus, J.5    Sharfman, W.H.6    Stankevich, E.7    Pons, A.8    Salay, T.M.9    McMiller, T.L.10
  • 65
    • 84871196652 scopus 로고    scopus 로고
    • Phase I study of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced solid tumors
    • abstr 2512
    • Patnaik A, Kang SP, Tolcher AW, Rasco DW, Papadopoulos KP, Beeram M, et al. Phase I study of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced solid tumors. J Clin Oncol 2012; 30:abstr 2512.
    • (2012) J Clin Oncol , vol.30
    • Patnaik, A.1    Kang, S.P.2    Tolcher, A.W.3    Rasco, D.W.4    Papadopoulos, K.P.5    Beeram, M.6
  • 66
    • 84878746239 scopus 로고    scopus 로고
    • PD-1/PD-L1 pathway as a target for cancer immunotherapy: safety and clinical activity of BMS-936559, an anti-PD-L1 antibody, in patients with solid tumors
    • abstr 2510
    • Tykodi SS, Brahmer JR, Hwu WJ, Chow LQ, Hwu P, Odunsi K, et al. PD-1/PD-L1 pathway as a target for cancer immunotherapy: safety and clinical activity of BMS-936559, an anti-PD-L1 antibody, in patients with solid tumors. J Clin Oncol 2012; 30:abstr 2510.
    • (2012) J Clin Oncol , vol.30
    • Tykodi, S.S.1    Brahmer, J.R.2    Hwu, W.J.3    Chow, L.Q.4    Hwu, P.5    Odunsi, K.6
  • 68
    • 77952315198 scopus 로고    scopus 로고
    • A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma
    • PMID:20133895
    • Hussein M, Berenson JR, Niesvizky R, Munshi N, Matous J, Sobecks R, Harrop K, Drachman JG, Whiting N. A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma. Haematologica 2010; 95:845-8; PMID:20133895; http://dx.doi.org/10.3324/haematol.2009.008003.
    • (2010) Haematologica , vol.95 , pp. 845-848
    • Hussein, M.1    Berenson, J.R.2    Niesvizky, R.3    Munshi, N.4    Matous, J.5    Sobecks, R.6    Harrop, K.7    Drachman, J.G.8    Whiting, N.9
  • 69
    • 76349120845 scopus 로고    scopus 로고
    • A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
    • PMID:20038235
    • Furman RR, Forero-Torres A, Shustov A, Drachman JG. A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma 2010; 51:228-35; PMID:20038235; http://dx.doi.org/10.3109/10428190903440946.
    • (2010) Leuk Lymphoma , vol.51 , pp. 228-235
    • Furman, R.R.1    Forero-Torres, A.2    Shustov, A.3    Drachman, J.G.4
  • 70
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • PMID:21074066
    • Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010; 37:508-16; PMID:21074066; http://dx.doi.org/10.1053/j. seminoncol.2010.09.008.
    • (2010) Semin Oncol , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.X.4    Melero, I.5
  • 71
    • 62549160588 scopus 로고    scopus 로고
    • First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting
    • PMID:18959794
    • Molckovsky A, Siu LL. First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting. J Hematol Oncol 2008; 1:20; PMID:18959794; http://dx.doi.org/10.1186/1756-8722-1-20.
    • (2008) J Hematol Oncol , vol.1 , pp. 20
    • Molckovsky, A.1    Siu, L.L.2
  • 76
    • 84880307128 scopus 로고    scopus 로고
    • Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanoma
    • PMID:23787916
    • Sherrill B, Wang J, Kotapati S, Chin K. Q-TWiST analysis comparing ipilimumab/dacarbazine vs placebo/dacarbazine for patients with stage III/IV melanoma. Br J Cancer 2013; 109:8-13; PMID:23787916; http://dx.doi.org/10.1038/bjc.2013.298.
    • (2013) Br J Cancer , vol.109 , pp. 8-13
    • Sherrill, B.1    Wang, J.2    Kotapati, S.3    Chin, K.4
  • 77
    • 84874116175 scopus 로고    scopus 로고
    • T cell profiling reveals high CD4+CTLA-4 + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment
    • PMID:22878899
    • Santegoets SJ, Stam AG, Lougheed SM, Gall H, Scholten PE, Reijm M, Jooss K, Sacks N, Hege K, Lowy I, et al. T cell profiling reveals high CD4+CTLA-4 + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment. Cancer Immunol Immunother 2013; 62:245-56; PMID:22878899; http://dx.doi. org/10.1007/s00262-012-1330-5.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 245-256
    • Santegoets, S.J.1    Stam, A.G.2    Lougheed, S.M.3    Gall, H.4    Scholten, P.E.5    Reijm, M.6    Jooss, K.7    Sacks, N.8    Hege, K.9    Lowy, I.10
  • 78
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • PMID:23550685
    • Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med 2013; 368:1365-6; PMID:23550685; http://dx.doi.org/10.1056/NEJMc1302338.
    • (2013) N Engl J Med , vol.368 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 79
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial
    • PMID:22858559
    • Reck M, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Lu H, Cuillerot JM, Lynch TJ. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 2013; 24:75-83; PMID:22858559; http://dx.doi.org/10.1093/annonc/mds213.
    • (2013) Ann Oncol , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Lu, H.8    Cuillerot, J.M.9    Lynch, T.J.10
  • 80
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • PMID:23924790
    • Le DT, Lutz E, Uram JN, Sugar EA, Onners B, Solt S, Zheng L, Diaz LA Jr., Donehower RC, Jaffee EM, et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J Immunother 2013; 36:382-9; PMID:23924790; http://dx.doi.org/10.1097/CJI.0b013e31829fb7a2.
    • (2013) J Immunother , vol.36 , pp. 382-389
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3    Sugar, E.A.4    Onners, B.5    Solt, S.6    Zheng, L.7    Diaz Jr., L.A.8    Donehower, R.C.9    Jaffee, E.M.10
  • 81
    • 84866551703 scopus 로고    scopus 로고
    • Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients
    • PMID:22956585
    • Kwek SS, Dao V, Roy R, Hou Y, Alajajian D, Simko JP, Small EJ, Fong L. Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients. J Immunol 2012; 189:3759-66; PMID:22956585; http://dx.doi.org/10.4049/jimmunol.1201529.
    • (2012) J Immunol , vol.189 , pp. 3759-3766
    • Kwek, S.S.1    Dao, V.2    Roy, R.3    Hou, Y.4    Alajajian, D.5    Simko, J.P.6    Small, E.J.7    Fong, L.8
  • 84
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • PMID:23295794
    • Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, Garbe C, Gogas H, Schachter J, Linette G, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol 2013; 31:616-22; PMID:23295794; http://dx.doi.org/10.1200/JCO.2012.44.6112.
    • (2013) J Clin Oncol , vol.31 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3    Punt, C.J.4    Haanen, J.B.5    Marmol, M.6    Garbe, C.7    Gogas, H.8    Schachter, J.9    Linette, G.10
  • 85
    • 84878570297 scopus 로고    scopus 로고
    • Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours
    • PMID:23652314
    • Millward M, Underhill C, Lobb S, McBurnie J, Meech SJ, Gomez-Navarro J, Marshall MA, Huang B, Mather CB. Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours. Br J Cancer 2013; 108:1998-2004; PMID:23652314; http://dx.doi.org/10.1038/bjc.2013.227.
    • (2013) Br J Cancer , vol.108 , pp. 1998-2004
    • Millward, M.1    Underhill, C.2    Lobb, S.3    McBurnie, J.4    Meech, S.J.5    Gomez-Navarro, J.6    Marshall, M.A.7    Huang, B.8    Mather, C.B.9
  • 86
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • PMID:23169436
    • Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, Xu H, Yao S, Pons A, Chen L, et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res 2013; 19:462-8; PMID:23169436; http://dx.doi.org/10.1158/1078-0432.CCR-12-2625.
    • (2013) Clin Cancer Res , vol.19 , pp. 462-468
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3    Wollner, I.4    Taube, J.M.5    Anders, R.A.6    Xu, H.7    Yao, S.8    Pons, A.9    Chen, L.10
  • 90
    • 84877805593 scopus 로고    scopus 로고
    • Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors
    • PMID:23483678
    • Vonderheide RH, Burg JM, Mick R, Trosko JA, Li D, Shaik MN, Tolcher AW, Hamid O. Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors. Oncoimmunology 2013; 2:e23033; PMID:23483678; http://dx.doi. org/10.4161/onci.23033.
    • (2013) Oncoimmunology , vol.2
    • Vonderheide, R.H.1    Burg, J.M.2    Mick, R.3    Trosko, J.A.4    Li, D.5    Shaik, M.N.6    Tolcher, A.W.7    Hamid, O.8
  • 92
    • 84888086049 scopus 로고    scopus 로고
    • A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
    • PMID:23983255
    • Beatty GL, Torigian DA, Chiorean EG, Saboury B, Brothers A, Alavi A, Troxel AB, Sun W, Teitelbaum UR, Vonderheide RH, et al. A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin Cancer Res 2013; 19:6286-95; PMID:23983255; http://dx.doi.org/10.1158/1078-0432.CCR-13-1320.
    • (2013) Clin Cancer Res , vol.19 , pp. 6286-6295
    • Beatty, G.L.1    Torigian, D.A.2    Chiorean, E.G.3    Saboury, B.4    Brothers, A.5    Alavi, A.6    Troxel, A.B.7    Sun, W.8    Teitelbaum, U.R.9    Vonderheide, R.H.10
  • 93
    • 84861754264 scopus 로고    scopus 로고
    • Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia
    • PMID:22475052
    • Byrd JC, Kipps TJ, Flinn IW, Cooper M, Odenike O, Bendiske J, Rediske J, Bilic S, Dey J, Baeck J, et al. Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia. Leuk Lymphoma 2012; 53:2136-42; PMID:22475052; http://dx.doi. org/10.3109/10428194.2012.681655.
    • (2012) Leuk Lymphoma , vol.53 , pp. 2136-2142
    • Byrd, J.C.1    Kipps, T.J.2    Flinn, I.W.3    Cooper, M.4    Odenike, O.5    Bendiske, J.6    Rediske, J.7    Bilic, S.8    Dey, J.9    Baeck, J.10
  • 107
    • 84874623052 scopus 로고    scopus 로고
    • Tremelimumab: a review of development to date in solid tumors
    • PMID:23444951
    • Tarhini AA. Tremelimumab: a review of development to date in solid tumors. Immunotherapy 2013; 5:215-29; PMID:23444951; http://dx.doi.org/10.2217/imt.13.9.
    • (2013) Immunotherapy , vol.5 , pp. 215-229
    • Tarhini, A.A.1
  • 108
    • 84866314973 scopus 로고    scopus 로고
    • A phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma
    • PMID:22861192
    • Bensinger W, Maziarz RT, Jagannath S, Spencer A, Durrant S, Becker PS, Ewald B, Bilic S, Rediske J, Baeck J, et al. A phase 1 study of lucatumumab, a fully human anti-CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma. Br J Haematol 2012; 159:58-66; PMID:22861192; http://dx.doi. org/10.1111/j.1365-2141.2012.09251.x.
    • (2012) Br J Haematol , vol.159 , pp. 58-66
    • Bensinger, W.1    Maziarz, R.T.2    Jagannath, S.3    Spencer, A.4    Durrant, S.5    Becker, P.S.6    Ewald, B.7    Bilic, S.8    Rediske, J.9    Baeck, J.10
  • 109
    • 79952939196 scopus 로고    scopus 로고
    • IPH-2101, a fully human anti-NK-cell inhibitory receptor mAb for the potential treatment of hematological cancers
    • PMID:21154164
    • Alici E. IPH-2101, a fully human anti-NK-cell inhibitory receptor mAb for the potential treatment of hematological cancers. Curr Opin Mol Ther 2010; 12:724-33; PMID:21154164.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 724-733
    • Alici, E.1
  • 110
    • 84875663346 scopus 로고    scopus 로고
    • Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy
    • PMID:23560068
    • Chacon JA, Wu RC, Sukhumalchandra P, Molldrem JJ, Sarnaik A, Pilon-Thomas S, Weber J, Hwu P, Radvanyi L. Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy. PLoS One 2013; 8:e60031; PMID:23560068; http://dx.doi.org/10.1371/journal. pone.0060031.
    • (2013) PLoS One , vol.8
    • Chacon, J.A.1    Wu, R.C.2    Sukhumalchandra, P.3    Molldrem, J.J.4    Sarnaik, A.5    Pilon-Thomas, S.6    Weber, J.7    Hwu, P.8    Radvanyi, L.9
  • 112
    • 84882827495 scopus 로고    scopus 로고
    • Decoding cell death signals in liver inflammation
    • PMID:23567086
    • Brenner C, Galluzzi L, Kepp O, Kroemer G. Decoding cell death signals in liver inflammation. J Hepatol 2013; 59:583-94; PMID:23567086; http://dx.doi.org/10.1016/j.jhep.2013.03.033.
    • (2013) J Hepatol , vol.59 , pp. 583-594
    • Brenner, C.1    Galluzzi, L.2    Kepp, O.3    Kroemer, G.4
  • 113
    • 57849159061 scopus 로고    scopus 로고
    • Toll-like receptors and cancer
    • PMID:19052556
    • Rakoff-Nahoum S, Medzhitov R. Toll-like receptors and cancer. Nat Rev Cancer 2009; 9:57-63; PMID:19052556; http://dx.doi.org/10.1038/nrc2541.
    • (2009) Nat Rev Cancer , vol.9 , pp. 57-63
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 114
    • 84875552922 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer therapy
    • PMID:23157435
    • Kroemer G, Galluzzi L, Kepp O, Zitvogel L. Immunogenic cell death in cancer therapy. Annu Rev Immunol 2013; 31:51-72; PMID:23157435; http://dx.doi.org/10.1146/annurev-immunol-032712-100008.
    • (2013) Annu Rev Immunol , vol.31 , pp. 51-72
    • Kroemer, G.1    Galluzzi, L.2    Kepp, O.3    Zitvogel, L.4
  • 117
    • 0036631492 scopus 로고    scopus 로고
    • Identification of tumour-associated T-cell epitopes for vaccine development
    • PMID:12094237
    • Stevanovic S. Identification of tumour-associated T-cell epitopes for vaccine development. Nat Rev Cancer 2002; 2:514-20; PMID:12094237; http://dx.doi.org/10.1038/nrc841.
    • (2002) Nat Rev Cancer , vol.2 , pp. 514-520
    • Stevanovic, S.1
  • 118
    • 67651231046 scopus 로고    scopus 로고
    • Immunotherapy: Vaccine trials in melanoma-time for reflection
    • PMID:19390551
    • Eggermont AM. Immunotherapy: Vaccine trials in melanoma-time for reflection. Nat Rev Clin Oncol 2009; 6:256-8; PMID:19390551; http://dx.doi. org/10.1038/nrclinonc.2009.42.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 256-258
    • Eggermont, A.M.1
  • 119
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • PMID:17898760
    • Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007; 449:419-26; PMID:17898760; http://dx.doi.org/10.1038/nature06175.
    • (2007) Nature , vol.449 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 120
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • PMID:22437871
    • Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer 2012; 12:265-77; PMID:22437871; http://dx.doi.org/10.1038/nrc3258.
    • (2012) Nat Rev Cancer , vol.12 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 123
    • 84887474711 scopus 로고    scopus 로고
    • Reassessing target antigens for adoptive T-cell therapy
    • PMID:24142051
    • Hinrichs CS, Restifo NP. Reassessing target antigens for adoptive T-cell therapy. Nat Biotechnol 2013; 31:999-1008; PMID:24142051; http://dx.doi. org/10.1038/nbt.2725.
    • (2013) Nat Biotechnol , vol.31 , pp. 999-1008
    • Hinrichs, C.S.1    Restifo, N.P.2
  • 124
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: harnessing the T cell response
    • PMID:22437939
    • Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012; 12:269-81; PMID:22437939; http://dx.doi.org/10.1038/nri3191.
    • (2012) Nat Rev Immunol , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.