-
1
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber, M. R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem. 79, 181-211 (2010).
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
3
-
-
0021821798
-
Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice
-
Martin, G. M., Smith, A. C., Ketterer, D. J., Ogburn, C. E. & Disteche, C. M. Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice. Isr. J. Med. Sci. 21, 296-301 (1985).
-
(1985)
Isr. J. Med. Sci.
, vol.21
, pp. 296-301
-
-
Martin, G.M.1
Smith, A.C.2
Ketterer, D.J.3
Ogburn, C.E.4
Disteche, C.M.5
-
4
-
-
57949116437
-
DNA PK: The means to justify the ends?
-
Meek, K., Dang, V. & Lees-Miller, S. P. DNA PK: the means to justify the ends? Adv. Immunol. 99, 33-58 (2008).
-
(2008)
Adv. Immunol.
, vol.99
, pp. 33-58
-
-
Meek, K.1
Dang, V.2
Lees-Miller, S.P.3
-
5
-
-
84995745398
-
Different DNA end configurations dictate which NHEJ components are most important for joining efficiency
-
Chang, H. H. Y. et al. Different DNA end configurations dictate which NHEJ components are most important for joining efficiency. J. Biol. Chem. 291, 24377-24389 (2016).
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 24377-24389
-
-
Chang, H.H.Y.1
-
6
-
-
33748089029
-
DNA PK autophosphorylation facilitates Artemis endonuclease activity
-
Goodarzi, A. A. et al. DNA PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J. 25, 3880-3889 (2006).
-
(2006)
EMBO J
, vol.25
, pp. 3880-3889
-
-
Goodarzi, A.A.1
-
7
-
-
77949658435
-
DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis
-
Gu, J. et al. DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst.) 9, 429-437 (2010).
-
(2010)
DNA Repair (Amst.)
, vol.9
, pp. 429-437
-
-
Gu, J.1
-
8
-
-
84943327656
-
Unifying the DNA end-processing roles of the artemis nuclease: Ku dependent Artemis resection at blunt DNA ends
-
Chang, H. H., Watanabe, G. & Lieber, M. R. Unifying the DNA end-processing roles of the artemis nuclease: Ku dependent Artemis resection at blunt DNA ends. J. Biol. Chem. 290, 24036-24050 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 24036-24050
-
-
Chang, H.H.1
Watanabe, G.2
Lieber, M.R.3
-
9
-
-
84976386612
-
Structure-specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex
-
Chang, H. H. & Lieber, M. R. Structure-specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex. Nucleic Acids Res. 44, 4991-4997 (2016).
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 4991-4997
-
-
Chang, H.H.1
Lieber, M.R.2
-
10
-
-
34247157802
-
Nucleases of the metallo-lactamase family and their role in DNA and RNA metabolism
-
Dominski, Z. Nucleases of the metallo-lactamase family and their role in DNA and RNA metabolism. Crit. Rev. Biochem. Mol. Biol. 42, 67-93 (2007).
-
(2007)
Crit. Rev. Biochem. Mol. Biol.
, vol.42
, pp. 67-93
-
-
Dominski, Z.1
-
11
-
-
84896289647
-
Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5 exonuclease activity
-
Li, S. et al. Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5 exonuclease activity. J. Biol. Chem. 289, 7825-7834 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 7825-7834
-
-
Li, S.1
-
12
-
-
0035917489
-
Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
-
Moshous, D. et al. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105, 177-186 (2001).
-
(2001)
Cell
, vol.105
, pp. 177-186
-
-
Moshous, D.1
-
13
-
-
0037155703
-
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
-
Ma, Y., Pannicke, U., Schwarz, K. & Lieber, M. R. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108, 781-794 (2002).
-
(2002)
Cell
, vol.108
, pp. 781-794
-
-
Ma, Y.1
Pannicke, U.2
Schwarz, K.3
Lieber, M.R.4
-
14
-
-
33750685856
-
DNA-PKcs dependence of artemis endonucleolytic activity: Differences between hairpins and 5 or 3 overhangs
-
Niewolik, D. et al. DNA-PKcs dependence of artemis endonucleolytic activity: differences between hairpins and 5 or 3 overhangs. J. Biol. Chem. 281, 33900-33909 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 33900-33909
-
-
Niewolik, D.1
-
15
-
-
85013768163
-
Autoinhibition of the nuclease ARTEMIS is mediated by a physical interaction between its catalytic and Cterminal domains
-
Niewolik, D., Peter, I., Butscher, C. & Schwarz, K. Autoinhibition of the nuclease ARTEMIS is mediated by a physical interaction between its catalytic and Cterminal domains. J. Biol. Chem. 292, 3351-3365 (2017).
-
(2017)
J. Biol. Chem.
, vol.292
, pp. 3351-3365
-
-
Niewolik, D.1
Peter, I.2
Butscher, C.3
Schwarz, K.4
-
16
-
-
84863798398
-
Artemis Cterminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs
-
Malu, S. et al. Artemis Cterminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. J. Exp. Med. 209, 955-963 (2012).
-
(2012)
J. Exp. Med.
, vol.209
, pp. 955-963
-
-
Malu, S.1
-
17
-
-
84871686867
-
Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining
-
De Ioannes, P., Malu, S., Cortes, P. & Aggarwal, A. K. Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining. Cell Rep. 2, 1505-1512 (2012).
-
(2012)
Cell Rep.
, vol.2
, pp. 1505-1512
-
-
Deoannes, P.1
Malu, S.2
Cortes, P.3
Aggarwal, A.K.4
-
18
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to H2AX foci
-
Riballo, E. et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to H2AX foci. Mol. Cell 16, 715-724 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
-
19
-
-
38349146485
-
The requirement of Artemis in double-strand break repair depends on the type of DNA damage
-
Kurosawa, A. et al. The requirement of Artemis in double-strand break repair depends on the type of DNA damage. DNA Cell Biol. 27, 55-61 (2008).
-
(2008)
DNA Cell Biol.
, vol.27
, pp. 55-61
-
-
Kurosawa, A.1
-
20
-
-
34247245102
-
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
-
Kanno, S. et al. A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. EMBO J. 26, 2094-2103 (2007).
-
(2007)
EMBO J
, vol.26
, pp. 2094-2103
-
-
Kanno, S.1
-
21
-
-
80054683238
-
Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3 exonuclease and can participate in DNA end joining in a biochemical system
-
Li, S. et al. Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3 exonuclease and can participate in DNA end joining in a biochemical system. J. Biol. Chem. 286, 36368-36377 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 36368-36377
-
-
Li, S.1
-
22
-
-
84872853376
-
APLF promotes the assembly and activity of non-homologous end joining protein complexes
-
Grundy, G. J. et al. APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J. 32, 112-125 (2013).
-
(2013)
EMBO J
, vol.32
, pp. 112-125
-
-
Grundy, G.J.1
-
23
-
-
84900298762
-
Nonhomologous end joining often uses microhomology: Implications for alternative end joining
-
Pannunzio, N. R., Li, S., Watanabe, G. & Lieber, M. R. Nonhomologous end joining often uses microhomology: implications for alternative end joining. DNA Repair (Amst.) 17, 74-80 (2014).
-
(2014)
DNA Repair (Amst.)
, vol.17
, pp. 74-80
-
-
Pannunzio, N.R.1
Li, S.2
Watanabe, G.3
Lieber, M.R.4
-
24
-
-
84899860411
-
Structure-function studies of DNA polymerase lambda
-
Bebenek, K., Pedersen, L. C. & Kunkel, T. A. Structure-function studies of DNA polymerase lambda. Biochemistry 53, 2781-2792 (2014).
-
(2014)
Biochemistry
, vol.53
, pp. 2781-2792
-
-
Bebenek, K.1
Pedersen, L.C.2
Kunkel, T.A.3
-
25
-
-
84895890321
-
Sustained active site rigidity during synthesis by human DNA polymerase ?
-
Moon, A. F. et al. Sustained active site rigidity during synthesis by human DNA polymerase ?. Nat. Struct. Mol. Biol. 21, 253-260 (2014).
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 253-260
-
-
Moon, A.F.1
-
26
-
-
9744241712
-
A biochemically defined system for mammalian nonhomologous DNA end joining
-
Ma, Y. et al. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol. Cell 16, 701-713 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 701-713
-
-
Ma, Y.1
-
27
-
-
33745997776
-
Non-overlapping functions of polX family DNA polymerases, pol m, pol l, and TdT, during immunoglobulin V(D)J recombination in vivo
-
Bertocci, B., DeSmet, A., Weill, J.C. & Reynaud, C. A. Non-overlapping functions of polX family DNA polymerases, pol m, pol l, and TdT, during immunoglobulin V(D)J recombination in vivo. Immunity 25, 31-41 (2006).
-
(2006)
Immunity
, vol.25
, pp. 31-41
-
-
Bertocci, B.1
DeSmet, A.2
Weill, J.C.3
Reynaud, C.A.4
-
28
-
-
84939856357
-
Essential role for polymerase specialization in cellular nonhomologous end joining
-
Pryor, J. M. et al. Essential role for polymerase specialization in cellular nonhomologous end joining. Proc. Natl Acad. Sci. USA 112, E4537-E4545 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. E4537-E4545
-
-
Pryor, J.M.1
-
29
-
-
0037379215
-
Polymerase is a DNA-directed DNA/RNA polymerase
-
NickMcElhinny, S. A. & Ramsden, D. A. Polymerase is a DNA-directed DNA/RNA polymerase. Mol. Cell. Biol. 23, 2309-2315 (2003).
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2309-2315
-
-
NickMcElhinny, S.A.1
Ramsden, D.A.2
-
30
-
-
23044453811
-
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining
-
NickMcElhinny, S. A. et al. A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol. Cell 19, 357-366 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 357-366
-
-
NickMcElhinny, S.A.1
-
31
-
-
33847193121
-
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
-
Gu, J. et al. XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J. 26, 1010-1023 (2007).
-
(2007)
EMBO J
, vol.26
, pp. 1010-1023
-
-
Gu, J.1
-
32
-
-
33745989838
-
The polymerases for V(D)J recombination
-
Lieber, M. R. The polymerases for V(D)J recombination. Immunity 25, 7-9 (2006).
-
(2006)
Immunity
, vol.25
, pp. 7-9
-
-
Lieber, M.R.1
-
33
-
-
23844464546
-
DNA joint dependence of pol X family polymerase action in nonhomologous end joining
-
Daley, J. M., Laan, R. L. V., Suresh, A. & Wilson, T. E. DNA joint dependence of pol X family polymerase action in nonhomologous end joining. J. Biol. Chem. 280, 29030-29037 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29030-29037
-
-
Daley, J.M.1
Laan, R.L.V.2
Suresh, A.3
Wilson, T.E.4
-
34
-
-
29244463205
-
Nonhomologous end joining in yeast
-
Daley, J. M., Palmbos, P. L., Wu, D. & Wilson, T. E. Nonhomologous end joining in yeast. Ann. Rev. Genet. 39, 431-451 (2005).
-
(2005)
Ann. Rev. Genet.
, vol.39
, pp. 431-451
-
-
Daley, J.M.1
Palmbos, P.L.2
Wu, D.3
Wilson, T.E.4
-
35
-
-
12844278880
-
Rejoining of DNA double-strand breaks as a function of overhang length
-
Daley, J. M. & Wilson, T. E. Rejoining of DNA double-strand breaks as a function of overhang length. Mol. Cell. Biol. 25, 896-906 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 896-906
-
-
Daley, J.M.1
Wilson, T.E.2
-
36
-
-
36549075614
-
Evidence that base stacking potential in annealed 3 overhangs determines polymerase utilization in yeast nonhomologous end joining
-
Daley, J. M. & Wilson, T. E. Evidence that base stacking potential in annealed 3 overhangs determines polymerase utilization in yeast nonhomologous end joining. DNA Repair (Amst.) 7, 67-76 (2007).
-
(2007)
DNA Repair (Amst.)
, vol.7
, pp. 67-76
-
-
Daley, J.M.1
Wilson, T.E.2
-
37
-
-
0030743386
-
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
-
Grawunder, U. et al. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388, 492-495 (1997).
-
(1997)
Nature
, vol.388
, pp. 492-495
-
-
Grawunder, U.1
-
38
-
-
0345505218
-
Nonhomologous end joining and V(D)J recombination require an additional factor
-
Dai, Y. et al. Nonhomologous end joining and V(D)J recombination require an additional factor. Proc. Natl Acad. Sci. USA 100, 2462-2467 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2462-2467
-
-
Dai, Y.1
-
39
-
-
31044432090
-
XLF interacts with the XRCC4-DNA ligase IV complex to promote nonhomologous end-joining
-
Ahnesorg, P., Smith, P. & Jackson, S. P. XLF interacts with the XRCC4-DNA ligase IV complex to promote nonhomologous end-joining. Cell 124, 301-313 (2006).
-
(2006)
Cell
, vol.124
, pp. 301-313
-
-
Ahnesorg, P.1
Smith, P.2
Jackson, S.P.3
-
40
-
-
31044440630
-
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
-
Buck, D. et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 124, 287-299 (2006).
-
(2006)
Cell
, vol.124
, pp. 287-299
-
-
Buck, D.1
-
41
-
-
84982683322
-
Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA
-
Brouwer, I. et al. Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA. Nature 535, 566-569 (2016).
-
(2016)
Nature
, vol.535
, pp. 566-569
-
-
Brouwer, I.1
-
43
-
-
84923107266
-
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway
-
Xing, M. et al. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat. Commun. 6, 6233 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6233
-
-
Xing, M.1
-
44
-
-
84938882573
-
XRCC4/XLF interaction is variably required for DNA repair and is not required for ligase IV stimulation
-
Roy, S. et al. XRCC4/XLF interaction is variably required for DNA repair and is not required for ligase IV stimulation. Mol. Cell. Biol. 35, 3017-3028 (2015).
-
(2015)
Mol. Cell. Biol.
, vol.35
, pp. 3017-3028
-
-
Roy, S.1
-
45
-
-
85004115646
-
PAXX is an accessory cNHEJ factor that associates with Ku70 and has overlapping functions with XLF
-
Tadi, S. K. et al. PAXX is an accessory cNHEJ factor that associates with Ku70 and has overlapping functions with XLF. Cell Rep. 17, 541-555 (2016).
-
(2016)
Cell Rep.
, vol.17
, pp. 541-555
-
-
Tadi, S.K.1
-
46
-
-
20044390734
-
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase
-
Bernstein, N. K. et al. The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Mol. Cell 17, 657-670 (2005).
-
(2005)
Mol. Cell
, vol.17
, pp. 657-670
-
-
Bernstein, N.K.1
-
47
-
-
33749821755
-
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
-
Ahel, I. et al. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443, 713-716 (2006).
-
(2006)
Nature
, vol.443
, pp. 713-716
-
-
Ahel, I.1
-
48
-
-
6344238643
-
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
-
Koch, C. A. et al. Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. EMBO J. 23, 3874-3885 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 3874-3885
-
-
Koch, C.A.1
-
49
-
-
0037178839
-
Conversion of phosphoglycolate to phosphate termini on 3 overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1
-
Inamdar, K. V. et al. Conversion of phosphoglycolate to phosphate termini on 3 overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. J. Biol. Chem. 277, 27162-27168 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27162-27168
-
-
Inamdar, K.V.1
-
50
-
-
37249068201
-
GC/MS methods to quantify the 2deoxypentos4ulose and 3 phosphoglycolate pathways of 4' oxidation of 2deoxyribose in DNA: Application to DNA damage produced by gamma radiation and bleomycin
-
Chen, B. et al. GC/MS methods to quantify the 2deoxypentos4ulose and 3 phosphoglycolate pathways of 4' oxidation of 2deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin. Chem. Res. Toxicol. 20, 1701-1708 (2007).
-
(2007)
Chem. Res. Toxicol.
, vol.20
, pp. 1701-1708
-
-
Chen, B.1
-
51
-
-
13744253911
-
Deficiency in 3 phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
-
Zhou, T. et al. Deficiency in 3 phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1). Nucleic Acids Res. 33, 289-297 (2005).
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 289-297
-
-
Zhou, T.1
-
52
-
-
0027014233
-
DNA structure, mutations and human genetic diseases
-
Sinden, R. R. & Wells, R. D. DNA structure, mutations and human genetic diseases. Curr. Opin. Biotechnol. 3, 612-622 (1992).
-
(1992)
Curr. Opin. Biotechnol.
, vol.3
, pp. 612-622
-
-
Sinden, R.R.1
Wells, R.D.2
-
53
-
-
0022827675
-
Mechanism of interaction between Ku protein and DNA
-
Mimori, T. & Hardin, J. A. Mechanism of interaction between Ku protein and DNA. J. Biol. Chem. 261, 10375-10379 (1986).
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 10375-10379
-
-
Mimori, T.1
Hardin, J.A.2
-
54
-
-
34247602569
-
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNAPK
-
Costantini, S., Woodbine, L., Andreoli, L., Jeggo, P. A. & Vindigni, A. Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNAPK. DNA Repair (Amst.) 6, 712-722 (2007).
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 712-722
-
-
Costantini, S.1
Woodbine, L.2
Andreoli, L.3
Jeggo, P.A.4
Vindigni, A.5
-
55
-
-
0035191378
-
Crystal structure of an Xrcc4-DNA ligase IV complex
-
Sibanda, B. L. et al. Crystal structure of an Xrcc4-DNA ligase IV complex. Nat. Struct. Biol. 8, 1015-1019 (2001).
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 1015-1019
-
-
Sibanda, B.L.1
-
56
-
-
0032544413
-
Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo
-
Grawunder, U., Zimmer, D., Kulesza, P. & Lieber, M. R. Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo. J. Biol. Chem. 273, 24708-24714 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24708-24714
-
-
Grawunder, U.1
Zimmer, D.2
Kulesza, P.3
Lieber, M.R.4
-
57
-
-
0032537803
-
DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains
-
Grawunder, U., Zimmer, D. & Lieber, M. R. DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains. Curr. Biol. 8, 873-876 (1998).
-
(1998)
Curr. Biol.
, vol.8
, pp. 873-876
-
-
Grawunder, U.1
Zimmer, D.2
Lieber, M.R.3
-
58
-
-
0034001205
-
Ku recruits the XRCC4-ligase IV complex to DNA ends
-
NickMcElhinny, S. A., Snowden, C. M., McCarville, J. & Ramsden, D. A. Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol. Cell. Biol. 20, 2996-3003 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2996-3003
-
-
NickMcElhinny, S.A.1
Snowden, C.M.2
McCarville, J.3
Ramsden, D.A.4
-
59
-
-
0032528066
-
Cerevisiae LIF1: A function involved in DNA double-strand break repair related to mammalian XRCC4
-
Herrmann, G., Lindahl, T. & Schar, P. S. cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4. EMBO J. 17, 4188-4198 (1998).
-
(1998)
EMBO J
, vol.17
, pp. 4188-4198
-
-
Herrmann, G.1
Lindahl, T.2
Schar, P.S.3
-
60
-
-
77952582707
-
Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae
-
Westmoreland, J. W., Summers, J. A., Holland, C. L., Resnick, M. A. & Lewis, L. K. Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae. DNA Repair (Amst.) 9, 617-626 (2010).
-
(2010)
DNA Repair (Amst.)
, vol.9
, pp. 617-626
-
-
Westmoreland, J.W.1
Summers, J.A.2
Holland, C.L.3
Resnick, M.A.4
Lewis, L.K.5
-
61
-
-
73849140503
-
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
-
Sibanda, B. L., Chirgadze, D. Y. & Blundell, T. L. Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature 463, 118-121 (2010).
-
(2010)
Nature
, vol.463
, pp. 118-121
-
-
Sibanda, B.L.1
Chirgadze, D.Y.2
Blundell, T.L.3
-
62
-
-
85011345113
-
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
-
Sibanda, B. L., Chirgadze, D. Y., Ascher, D. B. & Blundell, T. L. DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science 355, 520-524 (2017).
-
(2017)
Science
, vol.355
, pp. 520-524
-
-
Sibanda, B.L.1
Chirgadze, D.Y.2
Ascher, D.B.3
Blundell, T.L.4
-
63
-
-
0031708232
-
Productive and nonproductive complexes of Ku and DNAPK at DNA termini
-
West, R. B., Yaneva, M. & Lieber, M. R. Productive and nonproductive complexes of Ku and DNAPK at DNA termini. Mol. Cell. Biol. 18, 5908-5920 (1998).
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5908-5920
-
-
West, R.B.1
Yaneva, M.2
Lieber, M.R.3
-
64
-
-
33646714595
-
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair
-
Spagnolo, L., Rivera-Calzada, A., Pearl, L. H. & Llorca, O. Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol. Cell 22, 511-519 (2006).
-
(2006)
Mol. Cell
, vol.22
, pp. 511-519
-
-
Spagnolo, L.1
Rivera-Calzada, A.2
Pearl, L.H.3
Llorca, O.4
-
65
-
-
26644444577
-
The DNA-PKcs phosphorylation sites of human artemis
-
Ma, Y. et al. The DNA-PKcs phosphorylation sites of human artemis. J. Biol. Chem. 280, 33839-33846 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33839-33846
-
-
Ma, Y.1
-
66
-
-
49349116358
-
A biochemically defined system for coding joint formation in human V(D)J recombination
-
Lu, H. et al. A biochemically defined system for coding joint formation in human V(D)J recombination. Mol. Cell 31, 485-497 (2008).
-
(2008)
Mol. Cell
, vol.31
, pp. 485-497
-
-
Lu, H.1
-
67
-
-
0024469373
-
Effects of base sequence on the loop folding in DNA hairpins
-
Blommers, M. J. et al. Effects of base sequence on the loop folding in DNA hairpins. Biochemistry 28, 7491-7498 (1989).
-
(1989)
Biochemistry
, vol.28
, pp. 7491-7498
-
-
Blommers, M.J.1
-
68
-
-
84877824758
-
Processing of damaged DNA ends for double-strand break repair in mammalian cells
-
Povirk, L. F. Processing of damaged DNA ends for double-strand break repair in mammalian cells. ISRN Mol. Biol. 2012, 345805 (2012).
-
(2012)
ISRN Mol. Biol.
, vol.2012
, pp. 345805
-
-
Povirk, L.F.1
-
69
-
-
0021045679
-
Enzyme action at 3 termini of ionizing radiation-induced DNA strand breaks
-
Henner, W. D., Grunberg, S. M. & Haseltine, W. A. Enzyme action at 3 termini of ionizing radiation-induced DNA strand breaks. J. Biol. Chem. 258, 15198-15205 (1983).
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 15198-15205
-
-
Henner, W.D.1
Grunberg, S.M.2
Haseltine, W.A.3
-
70
-
-
0021111515
-
Ray induced deoxyribonucleic acid strand breaks3' glycolate termini
-
Henner, W. D., Rodriguez, L. O., Hecht, S. M. & Haseltine, W. A. ray induced deoxyribonucleic acid strand breaks. 3' glycolate termini. J. Biol. Chem. 258, 711-713 (1983).
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 711-713
-
-
Henner, W.D.1
Rodriguez, L.O.2
Hecht, S.M.3
Haseltine, W.A.4
-
71
-
-
0141757494
-
Regulation and mechanisms of mammalian double-strand break repair
-
Valerie, K. & Povirk, L. F. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22, 5792-5812 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 5792-5812
-
-
Valerie, K.1
Povirk, L.F.2
-
72
-
-
33947541157
-
Processing of 3 phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease
-
Povirk, L. F., Zhou, T., Zhou, R., Cowan, M. J. & Yannone, S. M. Processing of 3 phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease. J. Biol. Chem. 282, 3547-3558 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 3547-3558
-
-
Povirk, L.F.1
Zhou, T.2
Zhou, R.3
Cowan, M.J.4
Yannone, S.M.5
-
73
-
-
45549099011
-
Coordinate 5 and 3 endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
-
Yannone, S. M. et al. Coordinate 5 and 3 endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase. Nucleic Acids Res. 36, 3354-3365 (2008).
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 3354-3365
-
-
Yannone, S.M.1
-
74
-
-
84875880777
-
Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair
-
Ochi, T., Gu, X. & Blundell, T. L. Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure 21, 672-679 (2013).
-
(2013)
Structure
, vol.21
, pp. 672-679
-
-
Ochi, T.1
Gu, X.2
Blundell, T.L.3
-
75
-
-
33846075032
-
Structural insight into the substrate specificity of DNA polymerase mu
-
Moon, A. F. et al. Structural insight into the substrate specificity of DNA polymerase mu. Nat. Struc. Mol. Biol. 14, 45-53 (2007).
-
(2007)
Nat. Struc. Mol. Biol.
, vol.14
, pp. 45-53
-
-
Moon, A.F.1
-
76
-
-
0034669204
-
Crystal structure of the XRCC4 DNA repair protein and implications for end joining
-
Junop, M. S. et al. Crystal structure of the XRCC4 DNA repair protein and implications for end joining. EMBO J. 19, 5962-5970 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 5962-5970
-
-
Junop, M.S.1
-
77
-
-
37349113779
-
Crystal structure of human XLF: A twist in nonhomologous DNA end-joining
-
Andres, S. N., Modesti, M., Tsai, C. J., Chu, G. & Junop, M. S. Crystal structure of human XLF: a twist in nonhomologous DNA end-joining. Mol. Cell 28, 1093-1101 (2007).
-
(2007)
Mol. Cell
, vol.28
, pp. 1093-1101
-
-
Andres, S.N.1
Modesti, M.2
Tsai, C.J.3
Chu, G.4
Junop, M.S.5
-
78
-
-
34249938518
-
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
-
Tsai, C. J., Kim, S. A. & Chu, G. Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc. Natl Acad. Sci. USA 104, 7851-7856 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 7851-7856
-
-
Tsai, C.J.1
Kim, S.A.2
Chu, G.3
-
79
-
-
85008384621
-
PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
-
Liu, X., Shao, Z., Jiang, W., Lee, B. J. & Zha, S. PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice. Nat. Commun. 8, 13816 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 13816
-
-
Liu, X.1
Shao, Z.2
Jiang, W.3
Lee, B.J.4
Zha, S.5
-
80
-
-
84992061350
-
Synthetic lethality between PAXX and XLF in mammalian development
-
Balmus, G. et al. Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 30, 2152-2157 (2016).
-
(2016)
Genes Dev.
, vol.30
, pp. 2152-2157
-
-
Balmus, G.1
-
81
-
-
84991672318
-
Specific roles of XRCC4 paralogs PAXX and XLF during V(D)J recombination
-
Lescale, C. et al. Specific roles of XRCC4 paralogs PAXX and XLF during V(D)J recombination. Cell Rep. 16, 2967-2979 (2016).
-
(2016)
Cell Rep.
, vol.16
, pp. 2967-2979
-
-
Lescale, C.1
-
82
-
-
84988954710
-
PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1arrested progenitor Bcell line
-
Kumar, V., Alt, F. W. & Frock, R. L. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1arrested progenitor Bcell line. Proc. Natl Acad. Sci. USA 113, 10619-10624 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 10619-10624
-
-
Kumar, V.1
Alt, F.W.2
Frock, R.L.3
-
83
-
-
84983598244
-
Mutations in XRCC4 cause primordial dwarfism without causing immunodeficiency
-
Saito, S., Kurosawa, A. & Adachi, N. Mutations in XRCC4 cause primordial dwarfism without causing immunodeficiency. J. Hum. Genet. 61, 679-685 (2016).
-
(2016)
J. Hum. Genet.
, vol.61
, pp. 679-685
-
-
Saito, S.1
Kurosawa, A.2
Adachi, N.3
-
84
-
-
0029655319
-
Mechanistic constraints on diversity in human V(D)J recombination
-
Gauss, G. H. & Lieber, M. R. Mechanistic constraints on diversity in human V(D)J recombination. Mol. Cell. Biol. 16, 258-269 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 258-269
-
-
Gauss, G.H.1
Lieber, M.R.2
-
85
-
-
84978864815
-
Regulation of single-strand annealing and its role in genome maintenance
-
Bhargava, R., Onyango, D. O. & Stark, J. M. Regulation of single-strand annealing and its role in genome maintenance. Trends Genet. 32, 566-575 (2016).
-
(2016)
Trends Genet.
, vol.32
, pp. 566-575
-
-
Bhargava, R.1
Onyango, D.O.2
Stark, J.M.3
-
87
-
-
0032412476
-
Mating-type gene switching in Saccharomyces cerevisiae
-
Haber, J. E. Mating-type gene switching in Saccharomyces cerevisiae. Annu. Rev. Genet. 32, 561-599 (1998).
-
(1998)
Annu. Rev. Genet.
, vol.32
, pp. 561-599
-
-
Haber, J.E.1
-
88
-
-
77649131406
-
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
-
Moynahan, M. E. & Jasin, M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat. Rev. Mol. Cell Biol. 11, 196-207 (2010).
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 196-207
-
-
Moynahan, M.E.1
Jasin, M.2
-
89
-
-
77957805302
-
Ku prevents Exo1 and Sgs1 dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
-
Mimitou, E. P. & Symington, L. S. Ku prevents Exo1 and Sgs1 dependent resection of DNA ends in the absence of a functional MRX complex or Sae2. EMBO J. 29, 3358-3369 (2010).
-
(2010)
EMBO J
, vol.29
, pp. 3358-3369
-
-
Mimitou, E.P.1
Symington, L.S.2
-
90
-
-
84876877091
-
A cell cycle-dependent regulatory circuit composed of 53BP1RIF1 and BRCA1CtIP controls DNA repair pathway choice
-
Escribano-Diaz, C. et al. A cell cycle-dependent regulatory circuit composed of 53BP1RIF1 and BRCA1CtIP controls DNA repair pathway choice. Mol. Cell 49, 872-883 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 872-883
-
-
Escribano-Diaz, C.1
-
91
-
-
84938483671
-
Biochemical mechanism of DSB end resection and its regulation
-
Daley, J. M., Niu, H., Miller, A. S. & Sung, P. Biochemical mechanism of DSB end resection and its regulation. DNA Repair (Amst.) 32, 66-74 (2015).
-
(2015)
DNA Repair (Amst.)
, vol.32
, pp. 66-74
-
-
Daley, J.M.1
Niu, H.2
Miller, A.S.3
Sung, P.4
-
92
-
-
37349096996
-
Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
-
Xie, A. et al. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol. Cell 28, 1045-1057 (2007).
-
(2007)
Mol. Cell
, vol.28
, pp. 1045-1057
-
-
Xie, A.1
-
93
-
-
84893870945
-
A polymerase theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites
-
Koole, W. et al. A polymerase theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites. Nat. Commun. 5, 3216 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 3216
-
-
Koole, W.1
-
94
-
-
84976502375
-
DNA polymerase (POLQ), double-strand break repair, and cancer
-
Wood, R. D. & Doublie, S. DNA polymerase (POLQ), double-strand break repair, and cancer. DNA Repair (Amst.) 44, 22-32 (2016).
-
(2016)
DNA Repair (Amst.)
, vol.44
, pp. 22-32
-
-
Wood, R.D.1
Doublie, S.2
-
95
-
-
84992679760
-
Essential roles for polymerase theta mediated end joining in the repair of chromosome breaks
-
Wyatt, D. W. et al. Essential roles for polymerase theta mediated end joining in the repair of chromosome breaks. Mol. Cell 63, 662-673 (2016).
-
(2016)
Mol. Cell
, vol.63
, pp. 662-673
-
-
Wyatt, D.W.1
-
96
-
-
77957369329
-
Dual roles for DNA polymerase ? In alternative end-joining repair of double-strand breaks in Drosophila
-
Chan, S. H., Yu, A. M. & McVey, M. Dual roles for DNA polymerase ? in alternative end-joining repair of double-strand breaks in Drosophila. PLoS Genet. 6, e1001005 (2010).
-
(2010)
PLoS Genet.
, vol.6
, pp. e1001005
-
-
Chan, S.H.1
Yu, A.M.2
McVey, M.3
-
97
-
-
84975263081
-
Polymerase is a robust terminal transferase that oscillates between three different mechanisms during end-joining
-
Kent, T., Mateos-Gomez, P. A., Sfeir, A. & Pomerantz, R. T. Polymerase is a robust terminal transferase that oscillates between three different mechanisms during end-joining. eLife 5, e13740 (2016).
-
(2016)
ELife
, vol.5
, pp. e13740
-
-
Kent, T.1
Mateos-Gomez, P.A.2
Sfeir, A.3
Pomerantz, R.T.4
-
98
-
-
84923090502
-
Mammalian polymerase ? Promotes alternative NHEJ and suppresses recombination
-
Mateos-Gomez, P. A. et al. Mammalian polymerase ? promotes alternative NHEJ and suppresses recombination. Nature 518, 254-257 (2015).
-
(2015)
Nature
, vol.518
, pp. 254-257
-
-
Mateos-Gomez, P.A.1
-
99
-
-
84908326310
-
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ
-
Yousefzadeh, M. J. et al. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 10, e1004654 (2014).
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004654
-
-
Yousefzadeh, M.J.1
-
100
-
-
33745216905
-
Human DNA ligases I, III, and IVpurification and new specific assays for these enzymes
-
Chen, X. et al. Human DNA ligases I, III, and IVpurification and new specific assays for these enzymes. Methods Enzymol. 409, 39-52 (2006).
-
(2006)
Methods Enzymol.
, vol.409
, pp. 39-52
-
-
Chen, X.1
-
101
-
-
58149308524
-
Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells
-
Han, L. & Yu, K. Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells. J. Exp. Med. 205, 2745-2753 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2745-2753
-
-
Han, L.1
Yu, K.2
-
102
-
-
84956606129
-
Redundant function of DNA ligase 1 and 3 in alternative end joining during immunoglobulin class switch recombination
-
Masani, S., Han, L., Meek, K. & Yu, K. Redundant function of DNA ligase 1 and 3 in alternative end joining during immunoglobulin class switch recombination. Proc. Natl Acad. Sci. USA 113, 1261-1266 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 1261-1266
-
-
Masani, S.1
Han, L.2
Meek, K.3
Yu, K.4
-
103
-
-
84945916597
-
Microhomology-mediated end joining: A back up survival mechanism or dedicated pathway?
-
Sfeir, A. & Symington, L. S. Microhomology-mediated end joining: a back up survival mechanism or dedicated pathway? Trends Biochem. Sci. 40, 701-714 (2015).
-
(2015)
Trends Biochem. Sci.
, vol.40
, pp. 701-714
-
-
Sfeir, A.1
Symington, L.S.2
-
104
-
-
84903628980
-
Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection
-
Makharashvili, N. et al. Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection. Mol. Cell 54, 1022-1033 (2014).
-
(2014)
Mol. Cell
, vol.54
, pp. 1022-1033
-
-
Makharashvili, N.1
-
105
-
-
85003674344
-
Phosphorylated CtIP Functions as a cofactor of the MRE11RAD50NBS1 endonuclease in DNA end resection
-
Anand, R., Ranjha, L., Cannavo, E. & Cejka, P. Phosphorylated CtIP Functions as a cofactor of the MRE11RAD50NBS1 endonuclease in DNA end resection. Mol. Cell 64, 940-950 (2016).
-
(2016)
Mol. Cell
, vol.64
, pp. 940-950
-
-
Anand, R.1
Ranjha, L.2
Cannavo, E.3
Cejka, P.4
-
106
-
-
84995460857
-
Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts
-
Deshpande, R. A., Lee, J. H., Arora, S. & Paull, T. T. Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts. Mol. Cell 64, 593-606 (2016).
-
(2016)
Mol. Cell
, vol.64
, pp. 593-606
-
-
Deshpande, R.A.1
Lee, J.H.2
Arora, S.3
Paull, T.T.4
-
107
-
-
66049143898
-
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/cmyc translocations during immunoglobulin class switch recombination
-
Robert, I., Dantzer, F. & Reina-San-Martin, B. Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/cmyc translocations during immunoglobulin class switch recombination. J. Exp. Med. 206, 1047-1056 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1047-1056
-
-
Robert, I.1
Dantzer, F.2
Reina-San-Martin, B.3
-
108
-
-
79251481487
-
DNA polymerases and cancer
-
Lange, S. S., Takata, K. & Wood, R. D. DNA polymerases and cancer. Nat. Rev. Cancer 11, 96-110 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 96-110
-
-
Lange, S.S.1
Takata, K.2
Wood, R.D.3
-
109
-
-
77957235402
-
Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions
-
Yu, A. M. & McVey, M. Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions. Nucleic Acids Res. 38, 5706-5717 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 5706-5717
-
-
Yu, A.M.1
McVey, M.2
-
110
-
-
0004066515
-
Lymphoid V(D)J recombination: Nucleotide insertion at signal joints as well as coding joints
-
Lieber, M. R., Hesse, J. E., Mizuuchi, K. & Gellert, M. Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints. Proc. Natl Acad. Sci. USA 85, 8588-8592 (1988).
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 8588-8592
-
-
Lieber, M.R.1
Hesse, J.E.2
Mizuuchi, K.3
Gellert, M.4
-
111
-
-
84970968585
-
Mechanisms of human lymphoid chromosomal translocations
-
Lieber, M. R. Mechanisms of human lymphoid chromosomal translocations. Nat. Rev. Cancer 16, 387-398 (2016).
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 387-398
-
-
Lieber, M.R.1
-
112
-
-
77950446108
-
The t(14;18)(q32;q21)/IGHMALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma
-
Murga Penas, E. M. et al. The t(14;18)(q32;q21)/IGHMALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma. Blood 115, 2214-2219 (2010).
-
(2010)
Blood
, vol.115
, pp. 2214-2219
-
-
Murga Penas, E.M.1
-
113
-
-
0343953047
-
Follicular lymphomas BCL2/IgH junctions contain templated nucleotide insertions: Novel insights into the mechanism of t(14;18) translocation
-
Jaeger, U. et al. Follicular lymphomas BCL2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation. Blood 95, 3520-3529 (2000).
-
(2000)
Blood
, vol.95
, pp. 3520-3529
-
-
Jaeger, U.1
-
114
-
-
0035866359
-
Templated nucleotide addition and immunoglobulin JHgene utilization in t(11;14) junctions: Implications for the mechanism of translocation and the origin of mantle cell lymphoma
-
Welzel, N. et al. Templated nucleotide addition and immunoglobulin JHgene utilization in t(11;14) junctions: implications for the mechanism of translocation and the origin of mantle cell lymphoma. Cancer Res. 61, 1629-1636 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 1629-1636
-
-
Welzel, N.1
-
115
-
-
13244268505
-
Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
-
Pan-Hammarstrom, Q. et al. Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. J. Exp. Med. 201, 189-194 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 189-194
-
-
Pan-Hammarstrom, Q.1
-
116
-
-
84955360632
-
Repair pathway choices and consequences at the double-strand break
-
Ceccaldi, R., Rondinelli, B. & D'Andrea, A. D. Repair pathway choices and consequences at the double-strand break. Trends Cell Biol. 26, 52-64 (2016).
-
(2016)
Trends Cell Biol.
, vol.26
, pp. 52-64
-
-
Ceccaldi, R.1
Rondinelli, B.2
D'Andrea, A.D.3
-
117
-
-
85010703370
-
Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency
-
Bhargava, R., Carson, C. R., Lee, G. & Stark, J. M. Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency. Proc. Natl Acad. Sci. USA 114, 728-733 (2017).
-
(2017)
Proc. Natl Acad. Sci. USA
, vol.114
, pp. 728-733
-
-
Bhargava, R.1
Carson, C.R.2
Lee, G.3
Stark, J.M.4
-
118
-
-
84964434798
-
Mechanism and regulation of DNA end resection in eukaryotes
-
Symington, L. S. Mechanism and regulation of DNA end resection in eukaryotes. Crit. Rev. Biochem. Mol. Biol. 51, 195-212 (2016).
-
(2016)
Crit. Rev. Biochem. Mol. Biol.
, vol.51
, pp. 195-212
-
-
Symington, L.S.1
-
119
-
-
53649104599
-
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
-
Mimitou, E. P. & Symington, L. S. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455, 770-774 (2008).
-
(2008)
Nature
, vol.455
, pp. 770-774
-
-
Mimitou, E.P.1
Symington, L.S.2
-
120
-
-
51549095956
-
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
-
Zhu, Z., Chung, W. H., Shim, E. Y., Lee, S. E. & Ira, G. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134, 981-994 (2008).
-
(2008)
Cell
, vol.134
, pp. 981-994
-
-
Zhu, Z.1
Chung, W.H.2
Shim, E.Y.3
Lee, S.E.4
Ira, G.5
-
121
-
-
0242384946
-
Rad51 recombinase and recombination mediators
-
Sung, P., Krejci, L., Van Komen, S. & Sehorn, M. G. Rad51 recombinase and recombination mediators. J. Biol. Chem. 278, 42729-42732 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 42729-42732
-
-
Sung, P.1
Krejci, L.2
Van Komen, S.3
Sehorn, M.G.4
-
122
-
-
1842366037
-
Two pathways for removal of nonhomologous DNA ends during double-strand break repair in S
-
Paques, F. & Haber, J. E. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in S. cerevisiae. Mol. Cell. Biol. 17, 6765-6771 (1997).
-
(1997)
Cerevisiae. Mol. Cell. Biol.
, vol.17
, pp. 6765-6771
-
-
Paques, F.1
Haber, J.E.2
-
123
-
-
42249089039
-
RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae
-
Pannunzio, N. R., Manthey, G. M. & Bailis, A. M. RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae. DNA Repair (Amst.) 7, 788-800 (2008).
-
(2008)
DNA Repair (Amst.)
, vol.7
, pp. 788-800
-
-
Pannunzio, N.R.1
Manthey, G.M.2
Bailis, A.M.3
-
124
-
-
7244220162
-
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
-
Ira, G. et al. DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431, 1011-1017 (2004).
-
(2004)
Nature
, vol.431
, pp. 1011-1017
-
-
Ira, G.1
-
125
-
-
30344463835
-
ATM-and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri, A. et al. ATM-and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8, 37-45 (2006).
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
-
126
-
-
66149114020
-
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
-
Huertas, P. & Jackson, S. P. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284, 9558-9565 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 9558-9565
-
-
Huertas, P.1
Jackson, S.P.2
-
127
-
-
43149118369
-
Cell cycle-dependent complex formation of BRCA1
-
Chen, L., Nievera, C. J., Lee, A. Y. & Wu, X. Cell cycle-dependent complex formation of BRCA1. CtIP. MRN is important for DNA double-strand break repair. J. Biol. Chem. 283, 7713-7720 (2008).
-
(2008)
CtIP. MRN Is Important for DNA Double-strand Break Repair. J. Biol. Chem.
, vol.283
, pp. 7713-7720
-
-
Chen, L.1
Nievera, C.J.2
Lee, A.Y.3
Wu, X.4
-
128
-
-
84908045717
-
Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks
-
Cannavo, E. & Cejka, P. Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks. Nature 514, 122-125 (2014).
-
(2014)
Nature
, vol.514
, pp. 122-125
-
-
Cannavo, E.1
Cejka, P.2
-
129
-
-
80052492286
-
Cell cycle regulation of DNA double-strand break end resection by Cdk1 dependent Dna2 phosphorylation
-
Chen, X. et al. Cell cycle regulation of DNA double-strand break end resection by Cdk1 dependent Dna2 phosphorylation. Nat. Struct. Mol. Biol. 18, 1015-1019 (2011).
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 1015-1019
-
-
Chen, X.1
-
130
-
-
84930948486
-
Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice
-
Tomimatsu, N. et al. Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nat. Commun. 5, 3561 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 3561
-
-
Tomimatsu, N.1
-
131
-
-
85008147245
-
Regulation of the DNA damage response by DNA-PKcs inhibitory phosphorylation of ATM
-
Zhou, Y. et al. Regulation of the DNA damage response by DNA-PKcs inhibitory phosphorylation of ATM. Mol. Cell 65, 91-104 (2017).
-
(2017)
Mol. Cell
, vol.65
, pp. 91-104
-
-
Zhou, Y.1
-
132
-
-
70350763838
-
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
-
Beucher, A. et al. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J. 28, 3413-3427 (2009).
-
(2009)
EMBO J
, vol.28
, pp. 3413-3427
-
-
Beucher, A.1
-
133
-
-
85010869906
-
DNA double-strand break resection occurs during non-homologous end joining in G1 but is distinct from resection during homologous recombination
-
Biehs, R. et al. DNA double-strand break resection occurs during non-homologous end joining in G1 but is distinct from resection during homologous recombination. Mol. Cell 65, 671-684 (2017).
-
(2017)
Mol. Cell
, vol.65
, pp. 671-684
-
-
Biehs, R.1
-
134
-
-
0027156140
-
EBP80, a transcription factor closely resembling the human autoantigen Ku, recognizes single-to double-strand transitions in DNA
-
Falzon, M., Fewell, J. & Kuff, E. L. EBP80, a transcription factor closely resembling the human autoantigen Ku, recognizes single-to double-strand transitions in DNA. J. Biol. Chem. 268, 10546-10552 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 10546-10552
-
-
Falzon, M.1
Fewell, J.2
Kuff, E.L.3
-
135
-
-
84907976219
-
Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining
-
Ghezraoui, H. et al. Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining. Mol. Cell 55, 829-842 (2014).
-
(2014)
Mol. Cell
, vol.55
, pp. 829-842
-
-
Ghezraoui, H.1
-
136
-
-
77649267656
-
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70
-
Boboila, C. et al. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc. Natl Acad. Sci. USA 107, 3034-3039 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 3034-3039
-
-
Boboila, C.1
-
137
-
-
79953032797
-
Mechanisms that promote and suppress chromosomal translocations in lymphocytes
-
Gostissa, M., Alt, F. W. & Chiarle, R. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu. Rev. Immunol. 29, 319-350 (2011).
-
(2011)
Annu. Rev. Immunol.
, vol.29
, pp. 319-350
-
-
Gostissa, M.1
Alt, F.W.2
Chiarle, R.3
-
138
-
-
80053558376
-
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
-
Chiarle, R. et al. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell 147, 107-119 (2011).
-
(2011)
Cell
, vol.147
, pp. 107-119
-
-
Chiarle, R.1
-
139
-
-
84942030685
-
Congenital defects in V(D)J recombination
-
de Villartay, J. P. Congenital defects in V(D)J recombination. Br. Med. Bull. 114, 157-167 (2015).
-
(2015)
Br. Med. Bull.
, vol.114
, pp. 157-167
-
-
De Villartay, J.P.1
-
140
-
-
0037097787
-
A founder mutation in Artemis, an SNM1 like protein, causes SCID in Athabascan-speaking Native Americans
-
Li, L. et al. A founder mutation in Artemis, an SNM1 like protein, causes SCID in Athabascan-speaking Native Americans. J. Immunol. 168, 6323-6329 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 6323-6329
-
-
Li, L.1
-
141
-
-
84959253960
-
DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency
-
Volk, T. et al. DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency. Hum. Mol. Genet. 24, 7361-7372 (2015).
-
(2015)
Hum. Mol. Genet.
, vol.24
, pp. 7361-7372
-
-
Volk, T.1
-
142
-
-
84897026324
-
The clinical impact of deficiency in DNA non-homologous end-joining
-
Woodbine, L., Gennery, A. R. & Jeggo, P. A. The clinical impact of deficiency in DNA non-homologous end-joining. DNA Repair (Amst.) 16, 84-96 (2014).
-
(2014)
DNA Repair (Amst.)
, vol.16
, pp. 84-96
-
-
Woodbine, L.1
Gennery, A.R.2
Jeggo, P.A.3
-
143
-
-
84934441094
-
When natural mutants do not fit our expectations: The intriguing case of patients with XRCC4 mutations revealed by whole-exome sequencing
-
de Villartay, J. P. When natural mutants do not fit our expectations: the intriguing case of patients with XRCC4 mutations revealed by whole-exome sequencing. EMBO Mol. Med. 7, 862-864 (2015).
-
(2015)
EMBO Mol. Med.
, vol.7
, pp. 862-864
-
-
De Villartay, J.P.1
-
144
-
-
84983001496
-
XLF deficiency results in reduced Nnucleotide addition during V(D)J recombination
-
I.Jspeert, H. et al. XLF deficiency results in reduced Nnucleotide addition during V(D)J recombination. Blood 128, 650-659 (2016).
-
(2016)
Blood
, vol.128
, pp. 650-659
-
-
Ijspeert, H.1
-
145
-
-
61749104245
-
A DNA-PKcs mutation in a radiosensitive TB SCID patient inhibits Artemis activation and nonhomologous end-joining
-
Burg, M.v.d. et al. A DNA-PKcs mutation in a radiosensitive TB SCID patient inhibits Artemis activation and nonhomologous end-joining. J. Clin. Invest. 119, 91-98 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 91-98
-
-
Burg, M.V.D.1
-
146
-
-
84879655395
-
PRKDC mutations in a SCID patient with profound neurological abnormalities
-
Woodbine, L. et al. PRKDC mutations in a SCID patient with profound neurological abnormalities. J. Clin. Invest. 123, 2969-2980 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 2969-2980
-
-
Woodbine, L.1
-
147
-
-
84942619984
-
PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity
-
Mathieu, A. L. et al. PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J. Allergy Clin. Immunol. 135, 1578-1588.e5 (2015).
-
(2015)
J. Allergy Clin. Immunol.
, vol.135
, pp. 1578e5-1588e5
-
-
Mathieu, A.L.1
-
148
-
-
84959194281
-
Mechanisms underlying structural variant formation in genomic disorders
-
Carvalho, C. M. & Lupski, J. R. Mechanisms underlying structural variant formation in genomic disorders. Nat. Rev. Genet. 17, 224-238 (2016).
-
(2016)
Nat. Rev. Genet.
, vol.17
, pp. 224-238
-
-
Carvalho, C.M.1
Lupski, J.R.2
-
149
-
-
84931292199
-
Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms
-
Abyzov, A. et al. Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms. Nat. Commun. 6, 7256 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7256
-
-
Abyzov, A.1
-
150
-
-
78650959663
-
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
-
Stephens, P. J. et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144, 27-40 (2011).
-
(2011)
Cell
, vol.144
, pp. 27-40
-
-
Stephens, P.J.1
-
151
-
-
34248157719
-
APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks
-
Iles, N., Rulten, S., ElKhamisy, S. F. & Caldecott, K. W. APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Mol. Cell. Biol. 27, 3793-3803 (2007).
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3793-3803
-
-
Iles, N.1
Rulten, S.2
ElKhamisy, S.F.3
Caldecott, K.W.4
-
152
-
-
76349105464
-
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)
-
Eustermann, S. et al. Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat. Struct. Mol. Biol. 17, 241-243 (2010).
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 241-243
-
-
Eustermann, S.1
-
153
-
-
77952716489
-
Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response
-
Li, G. Y. et al. Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response. Proc. Natl Acad. Sci. USA 107, 9129-9134 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 9129-9134
-
-
Li, G.Y.1
-
154
-
-
78650745979
-
DNA repair factor APLF is a histone chaperone
-
Mehrotra, P. V. et al. DNA repair factor APLF is a histone chaperone. Mol. Cell 41, 46-55 (2011).
-
(2011)
Mol. Cell
, vol.41
, pp. 46-55
-
-
Mehrotra, P.V.1
|