Synthetic lethality between PAXX and XLF in mammalian development

Genes and Development

Volumn 30, Issue 19, 2016, Pages 2152-2157

  Balmus, Gabriel ^a,b   Barros, Ana C ^a,b   Wijnhoven, Paul W G ^a,c   Lescale, Chloé ^d   Hasse, Hélène Lenden ^d   Boroviak, Katharina ^b   le Sage, Carlos ^a,h   Doe, Brendan ^b   Speak, Anneliese O ^b   Galli, Antonella ^b   Jacobsen, Matt ^e   Deriano, Ludovic ^d   Adams, David J ^b   Blackford, Andrew N ^a,f,g   Jackson, Stephen P ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d INSTITUT PASTEUR   (France)

^e ASTRAZENECA   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h NONE   (United Kingdom)

Author keywords

ATM; Development; NHEJ; PAXX; Synthetic lethality; XLF

Indexed keywords

ATM PROTEIN; XRCC4 PROTEIN; DNA BINDING PROTEIN; O-(5-O-(4-COUMAROYL)-ALPHA-ARABINOFURANOSYL)-(1-3)-O-BETA-XYLOPYRANOSYL-(1-4)-XYLOPYRANOSE; PROTEIN KINASE; TRISACCHARIDE; XLF PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA REPAIR; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; EPISTASIS; FEMALE; FERTILITY; GENE; GENE INACTIVATION; GENE LOSS; GENOMIC INSTABILITY; KU80 GENE; LETHALITY; LIG4 GENE; MALE; MOUSE; NONHUMAN; PAXX GENE; PRIORITY JOURNAL; RADIOSENSITIVITY; SPLEEN LYMPHOCYTE; XLF GENE; ANIMAL; APOPTOSIS; C57BL MOUSE; GENETICS; KNOCKOUT MOUSE; LETHAL MUTATION; METABOLISM; RADIATION TOLERANCE;

ANIMALS; APOPTOSIS; DNA-BINDING PROTEINS; EMBRYONIC DEVELOPMENT; EPISTASIS, GENETIC; GENOMIC INSTABILITY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN KINASES; RADIATION TOLERANCE; SYNTHETIC LETHAL MUTATIONS; TRISACCHARIDES;

EID: 84992061350     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.290510.116     Document Type: Article

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