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Volumn 35, Issue 17, 2015, Pages 3017-3028

XRCC4/XLF Interaction is variably required for DNA repair and is not required for ligase IV stimulation

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DNA FRAGMENT; HISTONE H2AX; KU ANTIGEN; L115A PROTEIN; L115D PROTEIN; LIGASE; LIGASE 4; P53 BINDING PROTEIN 1; PAXX PROTEIN; PHLEOMYCIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG; XLF PROTEIN; XRCC4 PROTEIN; ATM PROTEIN, HUMAN; DNA; DNA BINDING PROTEIN; DNA LIGASE; DNA LIGASE (ATP); NHEJ1 PROTEIN, HUMAN; PAXX PROTEIN, HUMAN; XRCC4 PROTEIN, HUMAN;

EID: 84938882573     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01503-14     Document Type: Article
Times cited : (49)

References (73)
  • 2
    • 33750809977 scopus 로고    scopus 로고
    • Cernunnos-XLF, a recently identified non-homologous end-joining factor required for the development of the immune system
    • Revy P, Malivert L, de Villartay JP. 2006. Cernunnos-XLF, a recently identified non-homologous end-joining factor required for the development of the immune system. Curr Opin Allergy Clin Immunol 6:416-420. http://dx.doi.org/10.1097/01.all.0000246623.72365.43.
    • (2006) Curr Opin Allergy Clin Immunol , vol.6 , pp. 416-420
    • Revy, P.1    Malivert, L.2    de Villartay, J.P.3
  • 3
    • 31044432090 scopus 로고    scopus 로고
    • XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
    • Ahnesorg P, Smith P, Jackson SP. 2006. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124:301-313. http://dx.doi.org/10.1016/j.cell.2005.12.031.
    • (2006) Cell , vol.124 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3
  • 4
    • 37349113779 scopus 로고    scopus 로고
    • Crystal structure of human XLF: a twist in nonhomologous DNA end-joining
    • Andres SN, Modesti M, Tsai CJ, Chu G, Junop MS. 2007. Crystal structure of human XLF: a twist in nonhomologous DNA end-joining. Mol Cell 28:1093-1101. http://dx.doi.org/10.1016/j.molcel.2007.10.024.
    • (2007) Mol Cell , vol.28 , pp. 1093-1101
    • Andres, S.N.1    Modesti, M.2    Tsai, C.J.3    Chu, G.4    Junop, M.S.5
  • 9
    • 80053358977 scopus 로고    scopus 로고
    • Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions
    • Wu Q, Ochi T, Matak-Vinkovic D, Robinson CV, Chirgadze DY, Blundell TL. 2011. Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions. Biochem Soc Trans 39:1387-1392. http://dx.doi.org/10.1042/BST0391387.
    • (2011) Biochem Soc Trans , vol.39 , pp. 1387-1392
    • Wu, Q.1    Ochi, T.2    Matak-Vinkovic, D.3    Robinson, C.V.4    Chirgadze, D.Y.5    Blundell, T.L.6
  • 10
    • 34249938518 scopus 로고    scopus 로고
    • Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
    • Tsai CJ, Kim SA, Chu G. 2007. Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc Natl Acad Sci U S A 104:7851-7856. http://dx.doi.org/10.1073/pnas.0702620104.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7851-7856
    • Tsai, C.J.1    Kim, S.A.2    Chu, G.3
  • 11
  • 12
    • 34848841930 scopus 로고    scopus 로고
    • Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence
    • Gu J, Lu H, Tsai AG, Schwarz K, Lieber MR. 2007. Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res 35:5755-5762. http://dx.doi.org/10.1093/nar/gkm579.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5755-5762
    • Gu, J.1    Lu, H.2    Tsai, A.G.3    Schwarz, K.4    Lieber, M.R.5
  • 13
    • 33847193121 scopus 로고    scopus 로고
    • XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
    • Gu J, Lu H, Tippin B, Shimazaki N, Goodman MF, Lieber MR. 2007. XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J 26:1010-1023. http://dx.doi.org/10.1038/sj.emboj.7601559.
    • (2007) EMBO J , vol.26 , pp. 1010-1023
    • Gu, J.1    Lu, H.2    Tippin, B.3    Shimazaki, N.4    Goodman, M.F.5    Lieber, M.R.6
  • 15
    • 84897026324 scopus 로고    scopus 로고
    • The clinical impact of deficiency in DNA non-homologous end-joining
    • Woodbine L, Gennery AR, Jeggo PA. 2014. The clinical impact of deficiency in DNA non-homologous end-joining. DNA Repair 16:84-96. http://dx.doi.org/10.1016/j.dnarep.2014.02.011.
    • (2014) DNA Repair , vol.16 , pp. 84-96
    • Woodbine, L.1    Gennery, A.R.2    Jeggo, P.A.3
  • 16
    • 84887212606 scopus 로고    scopus 로고
    • Impaired replication stress response in cells from immunodeficiency patients carrying Cernunnos/XLF mutations
    • Schwartz M, Oren YS, Bester AC, Rahat A, Sfez R, Yitzchaik S, de Villartay JP, Kerem B. 2009. Impaired replication stress response in cells from immunodeficiency patients carrying Cernunnos/XLF mutations. PLoS One 4:e4516. http://dx.doi.org/10.1371/journal.pone.0004516.
    • (2009) PLoS One , vol.4
    • Schwartz, M.1    Oren, Y.S.2    Bester, A.C.3    Rahat, A.4    Sfez, R.5    Yitzchaik, S.6    de Villartay, J.P.7    Kerem, B.8
  • 17
    • 34248400443 scopus 로고    scopus 로고
    • Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells
    • Zha S, Alt FW, Cheng HL, Brush JW, Li G. 2007. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A 104:4518-4523. http://dx.doi.org/10.1073/pnas.0611734104.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4518-4523
    • Zha, S.1    Alt, F.W.2    Cheng, H.L.3    Brush, J.W.4    Li, G.5
  • 18
    • 49349083288 scopus 로고    scopus 로고
    • Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination
    • Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. 2008. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell 31:631-640. http://dx.doi.org/10.1016/j.molcel.2008.07.017.
    • (2008) Mol Cell , vol.31 , pp. 631-640
    • Li, G.1    Alt, F.W.2    Cheng, H.L.3    Brush, J.W.4    Goff, P.H.5    Murphy, M.M.6    Franco, S.7    Zhang, Y.8    Zha, S.9
  • 19
    • 84907013527 scopus 로고    scopus 로고
    • Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency
    • Avagyan S, Churchill M, Yamamoto K, Crowe JL, Li C, Lee BJ, Zheng T, Mukherjee S, Zha S. 2014. Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency. Blood 124:1622-1625. http://dx.doi.org/10.1182/blood-2014-05-574863.
    • (2014) Blood , vol.124 , pp. 1622-1625
    • Avagyan, S.1    Churchill, M.2    Yamamoto, K.3    Crowe, J.L.4    Li, C.5    Lee, B.J.6    Zheng, T.7    Mukherjee, S.8    Zha, S.9
  • 21
    • 84873427676 scopus 로고    scopus 로고
    • Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologousDNAend joining
    • Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. 2013. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologousDNAend joining. Proc Natl Acad Sci U S A 110:2234-2239. http://dx.doi.org/10.1073/pnas.1222573110.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 2234-2239
    • Oksenych, V.1    Kumar, V.2    Liu, X.3    Guo, C.4    Schwer, B.5    Zha, S.6    Alt, F.W.7
  • 22
    • 84857130477 scopus 로고    scopus 로고
    • Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair
    • Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. 2012. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A 109:2455-2460. http://dx.doi.org/10.1073/pnas.1121458109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2455-2460
    • Oksenych, V.1    Alt, F.W.2    Kumar, V.3    Schwer, B.4    Wesemann, D.R.5    Hansen, E.6    Patel, H.7    Su, A.8    Guo, C.9
  • 23
    • 48249121979 scopus 로고    scopus 로고
    • Complementary functions of ATM and H2AX in development and suppression of genomic instability
    • Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW. 2008. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A 105:9302-9306. http://dx.doi.org/10.1073/pnas.0803520105.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9302-9306
    • Zha, S.1    Sekiguchi, J.2    Brush, J.W.3    Bassing, C.H.4    Alt, F.W.5
  • 24
    • 84863268623 scopus 로고    scopus 로고
    • Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development
    • Liu X, Jiang W, Dubois RL, Yamamoto K, Wolner Z, Zha S. 2012. Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development. Proc Natl Acad Sci U S A 109:3903-3908. http://dx.doi.org/10.1073/pnas.1120160109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3903-3908
    • Liu, X.1    Jiang, W.2    Dubois, R.L.3    Yamamoto, K.4    Wolner, Z.5    Zha, S.6
  • 27
    • 0036316015 scopus 로고    scopus 로고
    • Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells
    • Lundin C, Erixon K, Arnaudeau C, Schultz N, Jenssen D, Meuth M, Helleday T. 2002. Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol Cell Biol 22:5869-5878. http://dx.doi.org/10.1128/MCB.22.16.5869-5878.2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 5869-5878
    • Lundin, C.1    Erixon, K.2    Arnaudeau, C.3    Schultz, N.4    Jenssen, D.5    Meuth, M.6    Helleday, T.7
  • 28
    • 0035898405 scopus 로고    scopus 로고
    • Characterization of homologous recombination induced by replication inhibition in mammalian cells
    • Saintigny Y, Delacote F, Vares G, Petitot F, Lambert S, Averbeck D, Lopez BS. 2001. Characterization of homologous recombination induced by replication inhibition in mammalian cells. EMBO J 20:3861-3870. http://dx.doi.org/10.1093/emboj/20.14.3861.
    • (2001) EMBO J , vol.20 , pp. 3861-3870
    • Saintigny, Y.1    Delacote, F.2    Vares, G.3    Petitot, F.4    Lambert, S.5    Averbeck, D.6    Lopez, B.S.7
  • 30
    • 79953134635 scopus 로고    scopus 로고
    • Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation
    • Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K. 2011. Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation. Mol Cell Biol 31:1719-1733. http://dx.doi.org/10.1128/MCB.01298-10.
    • (2011) Mol Cell Biol , vol.31 , pp. 1719-1733
    • Neal, J.A.1    Dang, V.2    Douglas, P.3    Wold, M.S.4    Lees-Miller, S.P.5    Meek, K.6
  • 31
    • 0034669204 scopus 로고    scopus 로고
    • Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
    • Junop MS, Modesti M, Guarne A, Ghirlando R, Gellert M, Yang W. 2000. Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J 19:5962-5970. http://dx.doi.org/10.1093/emboj/19.22.5962.
    • (2000) EMBO J , vol.19 , pp. 5962-5970
    • Junop, M.S.1    Modesti, M.2    Guarne, A.3    Ghirlando, R.4    Gellert, M.5    Yang, W.6
  • 33
    • 0028147898 scopus 로고
    • Production and characterization of recombinant human Ku antigen
    • Ono M, Tucker PW, Capra JD. 1994. Production and characterization of recombinant human Ku antigen. Nucleic Acids Res 22:3918-3924. http://dx.doi.org/10.1093/nar/22.19.3918.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3918-3924
    • Ono, M.1    Tucker, P.W.2    Capra, J.D.3
  • 35
    • 0023659483 scopus 로고
    • Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals
    • Hesse JE, Lieber MR, Gellert M, Mizuuchi K. 1987. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell 49:775-783. http://dx.doi.org/10.1016/0092-8674(87)90615-5.
    • (1987) Cell , vol.49 , pp. 775-783
    • Hesse, J.E.1    Lieber, M.R.2    Gellert, M.3    Mizuuchi, K.4
  • 36
    • 0033555686 scopus 로고    scopus 로고
    • A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally inCHOcells
    • Piechaczek C, Fetzer C, Baiker A, Bode J, Lipps HJ. 1999. A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally inCHOcells. Nucleic Acids Res 27:426-428. http://dx.doi.org/10.1093/nar/27.2.426.
    • (1999) Nucleic Acids Res , vol.27 , pp. 426-428
    • Piechaczek, C.1    Fetzer, C.2    Baiker, A.3    Bode, J.4    Lipps, H.J.5
  • 40
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
    • Koi M, Umar A, Chauhan DP, Cherian SP, Carethers JM, Kunkel TA, Boland CR. 1994. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res 54:4308-4312.
    • (1994) Cancer Res , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.P.3    Cherian, S.P.4    Carethers, J.M.5    Kunkel, T.A.6    Boland, C.R.7
  • 41
    • 44949096478 scopus 로고    scopus 로고
    • A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner
    • Wen Q, Scorah J, Phear G, Rodgers G, Rodgers S, Meuth M. 2008. A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell 19:1693-1705. http://dx.doi.org/10.1091/mbc.E07-09-0975.
    • (2008) Mol Biol Cell , vol.19 , pp. 1693-1705
    • Wen, Q.1    Scorah, J.2    Phear, G.3    Rodgers, G.4    Rodgers, S.5    Meuth, M.6
  • 43
    • 0023801238 scopus 로고
    • The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination
    • Lieber MR, Hesse JE, Lewis S, Bosma GC, Rosenberg N, Mizuuchi K, Bosma MJ, Gellert M. 1988. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55:7-16. http://dx.doi.org/10.1016/0092-8674(88)90004-9.
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenberg, N.5    Mizuuchi, K.6    Bosma, M.J.7    Gellert, M.8
  • 44
    • 0347683485 scopus 로고    scopus 로고
    • Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing
    • Roy R, Meier B, McAinsh AD, Feldmann HM, Jackson SP. 2004. Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing. J Biol Chem 279:86-94. http://dx.doi.org/10.1074/jbc.M306841200.
    • (2004) J Biol Chem , vol.279 , pp. 86-94
    • Roy, R.1    Meier, B.2    McAinsh, A.D.3    Feldmann, H.M.4    Jackson, S.P.5
  • 45
    • 78649707827 scopus 로고    scopus 로고
    • ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks
    • Bennardo N, Stark JM. 2010. ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks. PLoS Genet 6:e1001194. http://dx.doi.org/10.1371/journal.pgen.1001194.
    • (2010) PLoS Genet , vol.6
    • Bennardo, N.1    Stark, J.M.2
  • 47
    • 33745187351 scopus 로고    scopus 로고
    • In vitro nonhomologous DNA end joining system
    • Ma Y, Lieber MR. 2006. In vitro nonhomologous DNA end joining system. Methods Enzymol 408:502-510.
    • (2006) Methods Enzymol , vol.408 , pp. 502-510
    • Ma, Y.1    Lieber, M.R.2
  • 48
    • 84886866020 scopus 로고    scopus 로고
    • Double strand break repair functions of histone H2AX
    • Scully R, Xie A. 2013. Double strand break repair functions of histone H2AX. Mutat Res 750:5-14. http://dx.doi.org/10.1016/j.mrfmmm.2013.07.007.
    • (2013) Mutat Res , vol.750 , pp. 5-14
    • Scully, R.1    Xie, A.2
  • 49
    • 0026792892 scopus 로고
    • V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991. http://dx.doi.org/10.1016/0092-8674(92)90248-B.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 50
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma Y, Pannicke U, Schwarz K, Lieber MR. 2002. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108:781-794. http://dx.doi.org/10.1016/S0092-8674(02)00671-2.
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 51
    • 0027237601 scopus 로고
    • Coding end sequence can markedly affect the initiation of V(D)J recombination
    • Gerstein RM, Lieber MR. 1993. Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev 7:1459-1469. http://dx.doi.org/10.1101/gad.7.7b.1459.
    • (1993) Genes Dev , vol.7 , pp. 1459-1469
    • Gerstein, R.M.1    Lieber, M.R.2
  • 52
    • 34248231265 scopus 로고    scopus 로고
    • Transautophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
    • Meek K, Douglas P, Cui X, Ding Q, Lees-Miller SP. 2007. Transautophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Mol Cell Biol 27:3881-3890. http://dx.doi.org/10.1128/MCB.02366-06.
    • (2007) Mol Cell Biol , vol.27 , pp. 3881-3890
    • Meek, K.1    Douglas, P.2    Cui, X.3    Ding, Q.4    Lees-Miller, S.P.5
  • 54
    • 25444475799 scopus 로고    scopus 로고
    • Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model
    • Ma Y, Lu H, Schwarz K, Lieber MR. 2005. Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model. Cell Cycle 4:1193-1200. http://dx.doi.org/10.4161/cc.4.9.1977.
    • (2005) Cell Cycle , vol.4 , pp. 1193-1200
    • Ma, Y.1    Lu, H.2    Schwarz, K.3    Lieber, M.R.4
  • 55
    • 0033572709 scopus 로고    scopus 로고
    • Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein
    • Yoo S, Dynan WS. 1999. Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein. Nucleic Acids Res 27:4679-4686. http://dx.doi.org/10.1093/nar/27.24.4679.
    • (1999) Nucleic Acids Res , vol.27 , pp. 4679-4686
    • Yoo, S.1    Dynan, W.S.2
  • 56
    • 84874878472 scopus 로고    scopus 로고
    • XRCC4 and XLF form long helical protein filaments suitable forDNAend protection and alignment to facilitate DNA double strand break repair
    • Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP. 2013. XRCC4 and XLF form long helical protein filaments suitable forDNAend protection and alignment to facilitate DNA double strand break repair. Biochem Cell Biol 91:31-41. http://dx.doi.org/10.1139/bcb-2012-0058.
    • (2013) Biochem Cell Biol , vol.91 , pp. 31-41
    • Mahaney, B.L.1    Hammel, M.2    Meek, K.3    Tainer, J.A.4    Lees-Miller, S.P.5
  • 58
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • DeFazio LG, Stansel RM, Griffith JD, Chu G. 2002. Synapsis of DNA ends by DNA-dependent protein kinase. EMBOJ 21:3192-3200. http://dx.doi.org/10.1093/emboj/cdf299.
    • (2002) EMBOJ , vol.21 , pp. 3192-3200
    • DeFazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 59
    • 0037159220 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
    • Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP. 2002. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry 41:12706-12714. http://dx.doi.org/10.1021/bi0263558.
    • (2002) Biochemistry , vol.41 , pp. 12706-12714
    • Merkle, D.1    Douglas, P.2    Moorhead, G.B.3    Leonenko, Z.4    Yu, Y.5    Cramb, D.6    Bazett-Jones, D.P.7    Lees-Miller, S.P.8
  • 61
    • 84900463508 scopus 로고    scopus 로고
    • One ring to bring them all-the role of Ku in mammalian non-homologous end joining
    • Grundy GJ, Moulding HA, Caldecott KW, Rulten SL. 2014. One ring to bring them all-the role of Ku in mammalian non-homologous end joining. DNA Repair 17:30-38. http://dx.doi.org/10.1016/j.dnarep.2014.02.019.
    • (2014) DNA Repair , vol.17 , pp. 30-38
    • Grundy, G.J.1    Moulding, H.A.2    Caldecott, K.W.3    Rulten, S.L.4
  • 62
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker JR, Corpina RA, Goldberg J. 2001. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412:607-614. http://dx.doi.org/10.1038/35088000.
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 63
    • 80052765854 scopus 로고    scopus 로고
    • Destroying the ring: freeing DNA from Ku with ubiquitin
    • Postow L. 2011. Destroying the ring: freeing DNA from Ku with ubiquitin. FEBS Lett 585:2876-2882. http://dx.doi.org/10.1016/j.febslet.2011.05.046.
    • (2011) FEBS Lett , vol.585 , pp. 2876-2882
    • Postow, L.1
  • 64
    • 13844253934 scopus 로고    scopus 로고
    • Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs)
    • Rivera-Calzada A, Maman JD, Spagnolo L, Pearl LH, Llorca O. 2005. Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Structure 13:243-255. http://dx.doi.org/10.1016/j.str.2004.12.006.
    • (2005) Structure , vol.13 , pp. 243-255
    • Rivera-Calzada, A.1    Maman, J.D.2    Spagnolo, L.3    Pearl, L.H.4    Llorca, O.5
  • 66
    • 79952573454 scopus 로고    scopus 로고
    • Functional significance of the interaction with Ku inDNAdouble-strand break recognition of XLF
    • Yano K, Morotomi-Yano K, Lee KJ, Chen DJ. 2011. Functional significance of the interaction with Ku inDNAdouble-strand break recognition of XLF. FEBS Lett 585:841-846. http://dx.doi.org/10.1016/j.febslet.2011.02.020.
    • (2011) FEBS Lett , vol.585 , pp. 841-846
    • Yano, K.1    Morotomi-Yano, K.2    Lee, K.J.3    Chen, D.J.4
  • 67
    • 38049115657 scopus 로고    scopus 로고
    • The mechanism of human nonhomologous DNA end joining
    • Lieber MR. 2008. The mechanism of human nonhomologous DNA end joining. J Biol Chem 283:1-5. http://dx.doi.org/10.1074/jbc.R700039200.
    • (2008) J Biol Chem , vol.283 , pp. 1-5
    • Lieber, M.R.1
  • 69
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber MR. 2010. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79:181-211. http://dx.doi.org/10.1146/annurev.biochem.052308.093131.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 71
    • 3242875642 scopus 로고    scopus 로고
    • The DNAdependent protein kinase: the director at the end
    • Meek K, Gupta S, Ramsden DA, Lees-Miller SP. 2004. The DNAdependent protein kinase: the director at the end. Immunol Rev 200:132-141. http://dx.doi.org/10.1111/j.0105-2896.2004.00162.x.
    • (2004) Immunol Rev , vol.200 , pp. 132-141
    • Meek, K.1    Gupta, S.2    Ramsden, D.A.3    Lees-Miller, S.P.4
  • 72
    • 84905370561 scopus 로고    scopus 로고
    • DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells
    • Oh S, Harvey A, Zimbric J, Wang Y, Nguyen T, Jackson PJ, Hendrickson EA. 2014. DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells. DNA Repair 21:97-110. http://dx.doi.org/10.1016/j.dnarep.2014.04.015.
    • (2014) DNA Repair , vol.21 , pp. 97-110
    • Oh, S.1    Harvey, A.2    Zimbric, J.3    Wang, Y.4    Nguyen, T.5    Jackson, P.J.6    Hendrickson, E.A.7
  • 73
    • 38049144085 scopus 로고    scopus 로고
    • Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system
    • Lieber MR, Lu H, Gu J, Schwarz K. 2008. Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system. Cell Res 18:125-133. http://dx.doi.org/10.1038/cr.2007.108.
    • (2008) Cell Res , vol.18 , pp. 125-133
    • Lieber, M.R.1    Lu, H.2    Gu, J.3    Schwarz, K.4


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