Polymerase Mu is a DNA-directed DNA/RNA polymerase

Molecular and Cellular Biology

Volumn 23, Issue 7, 2003, Pages 2309-2315

  Nick McElhinny, Stephanie A ^a,b   Ramsden, Dale A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOTIDE; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED RNA POLYMERASE; DNA POLYMERASE MU; DOUBLE STRANDED DNA; RIBONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; DNA REPAIR; DNA STRAND BREAKAGE; DNA TEMPLATE; ENZYME ANALYSIS; ENZYME SPECIFICITY; HUMAN; PRIORITY JOURNAL;

CATIONS, DIVALENT; DEOXYRIBONUCLEOTIDES; DNA LIGASES; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA POLYMERASE BETA; DNA-DIRECTED DNA POLYMERASE; DNA-DIRECTED RNA POLYMERASES; HUMANS; OLIGONUCLEOTIDES; RIBONUCLEOTIDES; SUBSTRATE SPECIFICITY;

EID: 0037379215     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.7.2309-2315.2003     Document Type: Article

References (26)

1. Aoufouchi, S., E. Flatter, A. Dahan, A. Faili, B. Bertocci, S. Storck, F. Delbos, L. Cocea, N. Gupta, J. C. Weill, and C. A. Reynaud. 2000. Two novel human and mouse DNA polymerases of the polX family. Nucleic Acids Res. 28:3684-3693.
2. Arzumanov, A. A., L. S. Victorova, M. V. Jasko, D. S. Yesipov, and A. A. Krayevsky. 2000. Terminal deoxynucleotidyl transferase catalyzes the reaction of DNA phosphorylation. Nucleic Acids Res. 28:1276-1281.
3. Bjursell, G., and L. Skoog. 1980. Control of nucleotide pools in mammalian cells. Antibiot. Chemother. 28:78-85.
4. Boule, J. B., F. Rougeon, and C. Papanicolaou. 2001. Terminal deoxynucleotidyl transferase indiscriminately incorporates ribonucleotides and deoxyribonucleotides. J. Biol. Chem. 276:31388-31393.
5. Burgers, P. M., E. V. Koonin, E. Bruford, L. Blanco, K. C. Burtis, M. F. Christman, W. C. Copeland, E. C. Friedberg, F. Hanaoka, D. C. Hinkle, C. W. Lawrence, M. Nakanishi, H. Ohmori, L. Prakash, S. Prakash, C. A. Reynaud, A. Sugino, T. Todo, Z. Wang, J. C. Weill, and R. Woodgate. 2001. Eukaryotic DNA polymerases: proposal for a revised nomenclature. J. Biol. Chem. 276:43487-43490,
6. Chang, L. M., and F. J. Bollum. 1986. Molecular biology of terminal transferase. Crit. Rev. Biochem. 21:27-52.
7. Dominguez, O., J. F. Ruiz, T. Lain de Lera, M. Garcia-Diaz, M. A. Gonzalez, T. Kirchhoff, A. C. Martinez, A. Bernad, and L. Blanco. 2000. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. EMBO J. 19:1731-1742.
8. Eder, P. S., and J. A. Walder. 1991. Ribonuclease H from K562 human erythroleukemia cells. Purification, characterization, and substrate specificity. J. Biol. Chem. 266:6472-6479.
9. Gellert, M. 2002, V(D)J recombination: rag proteins, repair factors, and regulation. Annu. Rev. Biochem. 71:101-132.
10. Gilfillan, S., C. Benoist, and D. Mathis. 1995. Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire. Immunol. Rev. 148:201-219.
11. Joyce, C. M. 1997. Choosing the right sugar: how polymerases select a nucleotide substrate. Proc. Natl. Acad. Sci. USA 94:1619-1622.
12. Kato, K. I., J. M. Goncalves, G. E. Houts, and F. J. Bollum. 1967. Deoxynucleotide-polymerizing enzymes of calf thymus gland. II. Properties of the terminal deoxynucleotidyltransferase. J. Biol. Chem. 242:2780-2789.
13. Kornberg, A., and T. Baker. 1992. DNA replication, 2nd ed. W. H. Freeman and Company, New York, N.Y.
14. Mahajan, K. N., S. A. Nick McElhinny, B. S. Mitchell, and D. A. Ramsden. 2002. Association of DNA polymerase μ (pol μ) with Ku and ligase IV: role for pol μ in end-joining double-strand break repair. Mol. Cell. Biol. 22:5194-5202.
15. McCormick, P. J., L. L. Danhauser, Y. M. Rustum, and J. S. Bertram. 1983. Changes in ribo- and deoxyribonucleoside triphosphate pools within the cell cycle of a synchronized mouse fibroblast cell line. Biochim. Biophys. Acta 756:36-40.
16. Nick McElhinny, S. A., C. M. Snowden, J. McCarville, and D. A. Ramsden. 2000. Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol. Cell. Biol. 20:2996-3003.
17. Prasad, R., A. Kumar, S. G. Widen, J. R. Casas-Finet, and S. H. Wilson. 1993. Identification of residues in the single-stranded DNA-binding site of the 8-kDa domain of rat DNA polymerase beta by UV cross-linking. J. Biol. Chem. 268:22746-22755.
18. Reichard, P. 1988. Interactions between deoxyribonucleotide and DNA synthesis. Annu. Rev. Biochem. 57:349-374.
19. Robins, P., and T. Lindahl. 1996. DNA ligase IV from HeLa cell nuclei. J. Biol. Chem. 271:24257-24261.
20. Roychoudhury, R. 1972. Enzymic synthesis of polynucleotides. Oligodeoxynucleotides with one 3′-terminal ribonucleotide as primers for polydeoxynucleotide synthesis. J. Biol. Chem. 247:3910-3917.
21. Roychoudhury, R., and H. Kossel. 1971. Synthetic polynucleotides, Enzymic synthesis of ribonucleotide terminated oligodeoxynucleotides and their use as primers for the enzymic synthesis of polydeoxynucleotides. Eur. J. Biochem. 22:310-320.
22. Rydberg, B., and J. Game. 2002. Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts. Proc. Natl. Acad. Sci. USA 99:16654-16659.
23. Singhal, R. K., and S. H. Wilson, 1993. Short gap-filling synthesis by DNA polymerase beta is processive. J. Biol. Chem. 268:15906-15911.
24. Takata, M., M. S. Sasaki, E. Sonoda, C. Morrison, M. Hashimoto, H. Utsumi, Y. Yamaguchi-Iwai, A. Shinohara, and S. Takeda. 1998. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17:5497-5508.
25. Traut, T. W. 1994. Physiological concentrations of purines and pyrimidines. Mol. Cell. Biochem. 140:1-22.
26. Zhang, Y., X. Wu, F. Yuan, Z. Xie, and Z. Wang. 2001. Highly frequent frameshift DNA synthesis by human DNA polymerase mu. Mol. Cell. Biol. 21:7995-8006.