GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3′-phosphoglycolate pathways of 4′ oxidation of 2-deoxyribose in DNA: Application to DNA damage produced by γ radiation and bleomycin

Chemical Research in Toxicology

Volumn 20, Issue 11, 2007, Pages 1701-1708

  Chen, Bingzi ^a   Zhou, Xinfeng ^a,c   Taghizadeh, Koli ^a   Chen, Jingyang ^b,d   Stubbe, JoAnne ^b   Dedon, Peter C ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Federal Service for Surveillance on Consumer Rights Protection and Human Well Being   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEOXYPENTOS 4 ULOSE; 2 DEOXYRIBOSE; 2 PHOSPHOGLYCOLIC ACID; 3' PHOSPHOGLYCOLATE; ACROLEIN; BLEOMYCIN; CARBOHYDRATE DERIVATIVE; DNA; GLYCOLIC ACID DERIVATIVE; MALONALDEHYDE; NICOTINYL ALCOHOL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME PURIFICATION; GAMMA IRRADIATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; NONHUMAN; OXIDATION KINETICS; SILYLATION; VALIDATION PROCESS;

BLEOMYCIN; DEOXYRIBOSE; DNA; DNA DAMAGE; GAMMA RAYS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCOLATES; OXIDATION-REDUCTION;

EID: 37249068201     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700164y     Document Type: Article

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