-
1
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L.B., Nik-Zainal, S., Wedge, D.C., Aparicio, S.A.J.R., Behjati, S., Biankin, A.V., Bignell, G.R., Bolli, N., Borg, A., Børresen-Dale, A.-L., et al. Australian Pancreatic Cancer Genome Initiative ICGC Breast Cancer Consortium ICGC MMML-Seq Consortium, ICGC PedBrain. Signatures of mutational processes in human cancer. Nature 500 (2013), 415–421.
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.J.R.4
Behjati, S.5
Biankin, A.V.6
Bignell, G.R.7
Bolli, N.8
Borg, A.9
Børresen-Dale, A.-L.10
-
2
-
-
84902116617
-
DNA double-strand break repair pathway choice and cancer
-
Aparicio, T., Baer, R., Gautier, J., DNA double-strand break repair pathway choice and cancer. DNA Repair (Amst.) 19 (2014), 169–175.
-
(2014)
DNA Repair (Amst.)
, vol.19
, pp. 169-175
-
-
Aparicio, T.1
Baer, R.2
Gautier, J.3
-
3
-
-
46349087126
-
Low-fidelity DNA synthesis by human DNA polymerase theta
-
Arana, M.E., Seki, M., Wood, R.D., Rogozin, I.B., Kunkel, T.A., Low-fidelity DNA synthesis by human DNA polymerase theta. Nucleic Acids Res. 36 (2008), 3847–3856.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 3847-3856
-
-
Arana, M.E.1
Seki, M.2
Wood, R.D.3
Rogozin, I.B.4
Kunkel, T.A.5
-
4
-
-
46249131123
-
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
-
Bennardo, N., Cheng, A., Huang, N., Stark, J.M., Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet., 4, 2008, e1000110.
-
(2008)
PLoS Genet.
, vol.4
, pp. e1000110
-
-
Bennardo, N.1
Cheng, A.2
Huang, N.3
Stark, J.M.4
-
5
-
-
0029791694
-
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
-
Boulton, S.J., Jackson, S.P., Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15 (1996), 5093–5103.
-
(1996)
EMBO J.
, vol.15
, pp. 5093-5103
-
-
Boulton, S.J.1
Jackson, S.P.2
-
6
-
-
77953291328
-
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
-
Bouwman, P., Aly, A., Escandell, J.M., Pieterse, M., Bartkova, J., van der Gulden, H., Hiddingh, S., Thanasoula, M., Kulkarni, A., Yang, Q., et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat. Struct. Mol. Biol. 17 (2010), 688–695.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 688-695
-
-
Bouwman, P.1
Aly, A.2
Escandell, J.M.3
Pieterse, M.4
Bartkova, J.5
van der Gulden, H.6
Hiddingh, S.7
Thanasoula, M.8
Kulkarni, A.9
Yang, Q.10
-
7
-
-
77950958141
-
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
-
Bunting, S.F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141 (2010), 243–254.
-
(2010)
Cell
, vol.141
, pp. 243-254
-
-
Bunting, S.F.1
Callén, E.2
Wong, N.3
Chen, H.-T.4
Polato, F.5
Gunn, A.6
Bothmer, A.7
Feldhahn, N.8
Fernandez-Capetillo, O.9
Cao, L.10
-
8
-
-
84923082911
-
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
-
Ceccaldi, R., Liu, J.C., Amunugama, R., Hajdu, I., Primack, B., Petalcorin, M.I.R., O'Connor, K.W., Konstantinopoulos, P.A., Elledge, S.J., Boulton, S.J., et al. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature 518 (2015), 258–262.
-
(2015)
Nature
, vol.518
, pp. 258-262
-
-
Ceccaldi, R.1
Liu, J.C.2
Amunugama, R.3
Hajdu, I.4
Primack, B.5
Petalcorin, M.I.R.6
O'Connor, K.W.7
Konstantinopoulos, P.A.8
Elledge, S.J.9
Boulton, S.J.10
-
9
-
-
77957369329
-
Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila
-
Chan, S.H., Yu, A.M., McVey, M., Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila. PLoS Genet., 6, 2010, e1001005.
-
(2010)
PLoS Genet.
, vol.6
, pp. e1001005
-
-
Chan, S.H.1
Yu, A.M.2
McVey, M.3
-
10
-
-
79251525596
-
Overexpression of POLQ confers a poor prognosis in early breast cancer patients
-
Higgins, G.S., Harris, A.L., Prevo, R., Helleday, T., McKenna, W.G., Buffa, F.M., Overexpression of POLQ confers a poor prognosis in early breast cancer patients. Oncotarget 1 (2010), 175–184.
-
(2010)
Oncotarget
, vol.1
, pp. 175-184
-
-
Higgins, G.S.1
Harris, A.L.2
Prevo, R.3
Helleday, T.4
McKenna, W.G.5
Buffa, F.M.6
-
11
-
-
0032404178
-
Double-strand break repair in Ku86- and XRCC4-deficient cells
-
Kabotyanski, E.B., Gomelsky, L., Han, J.O., Stamato, T.D., Roth, D.B., Double-strand break repair in Ku86- and XRCC4-deficient cells. Nucleic Acids Res. 26 (1998), 5333–5342.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 5333-5342
-
-
Kabotyanski, E.B.1
Gomelsky, L.2
Han, J.O.3
Stamato, T.D.4
Roth, D.B.5
-
12
-
-
84924232532
-
Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ
-
Kent, T., Chandramouly, G., McDevitt, S.M., Ozdemir, A.Y., Pomerantz, R.T., Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ. Nat. Struct. Mol. Biol. 22 (2015), 230–237.
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 230-237
-
-
Kent, T.1
Chandramouly, G.2
McDevitt, S.M.3
Ozdemir, A.Y.4
Pomerantz, R.T.5
-
13
-
-
34548401682
-
Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining
-
Lee, K., Lee, S.E., Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining. Genetics 176 (2007), 2003–2014.
-
(2007)
Genetics
, vol.176
, pp. 2003-2014
-
-
Lee, K.1
Lee, S.E.2
-
14
-
-
77955820979
-
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability
-
Lemée, F., Bergoglio, V., Fernandez-Vidal, A., Machado-Silva, A., Pillaire, M.-J., Bieth, A., Gentil, C., Baker, L., Martin, A.-L., Leduc, C., et al. DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc. Natl. Acad. Sci. USA 107 (2010), 13390–13395.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 13390-13395
-
-
Lemée, F.1
Bergoglio, V.2
Fernandez-Vidal, A.3
Machado-Silva, A.4
Pillaire, M.-J.5
Bieth, A.6
Gentil, C.7
Baker, L.8
Martin, A.-L.9
Leduc, C.10
-
15
-
-
0036304829
-
DNA polymerase theta purified from human cells is a high-fidelity enzyme
-
Maga, G., Shevelev, I., Ramadan, K., Spadari, S., Hübscher, U., DNA polymerase theta purified from human cells is a high-fidelity enzyme. J. Mol. Biol. 319 (2002), 359–369.
-
(2002)
J. Mol. Biol.
, vol.319
, pp. 359-369
-
-
Maga, G.1
Shevelev, I.2
Ramadan, K.3
Spadari, S.4
Hübscher, U.5
-
16
-
-
84923090502
-
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
-
Mateos-Gomez, P.A., Gong, F., Nair, N., Miller, K.M., Lazzerini-Denchi, E., Sfeir, A., Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination. Nature 518 (2015), 254–257.
-
(2015)
Nature
, vol.518
, pp. 254-257
-
-
Mateos-Gomez, P.A.1
Gong, F.2
Nair, N.3
Miller, K.M.4
Lazzerini-Denchi, E.5
Sfeir, A.6
-
17
-
-
84949215325
-
Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway
-
Newman, J.A., Cooper, C.D.O., Aitkenhead, H., Gileadi, O., Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. Structure 23 (2015), 2319–2330.
-
(2015)
Structure
, vol.23
, pp. 2319-2330
-
-
Newman, J.A.1
Cooper, C.D.O.2
Aitkenhead, H.3
Gileadi, O.4
-
18
-
-
0035893363
-
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
-
Pierce, A.J., Hu, P., Han, M., Ellis, N., Jasin, M., Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15 (2001), 3237–3242.
-
(2001)
Genes Dev.
, vol.15
, pp. 3237-3242
-
-
Pierce, A.J.1
Hu, P.2
Han, M.3
Ellis, N.4
Jasin, M.5
-
19
-
-
84939856357
-
Essential role for polymerase specialization in cellular nonhomologous end joining
-
Pryor, J.M., Waters, C.A., Aza, A., Asagoshi, K., Strom, C., Mieczkowski, P.A., Blanco, L., Ramsden, D.A., Essential role for polymerase specialization in cellular nonhomologous end joining. Proc. Natl. Acad. Sci. USA 112 (2015), E4537–E4545.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. E4537-E4545
-
-
Pryor, J.M.1
Waters, C.A.2
Aza, A.3
Asagoshi, K.4
Strom, C.5
Mieczkowski, P.A.6
Blanco, L.7
Ramsden, D.A.8
-
20
-
-
84901823399
-
Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans
-
Roerink, S.F., van Schendel, R., Tijsterman, M., Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans. Genome Res. 24 (2014), 954–962.
-
(2014)
Genome Res.
, vol.24
, pp. 954-962
-
-
Roerink, S.F.1
van Schendel, R.2
Tijsterman, M.3
-
21
-
-
84953374838
-
Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements
-
Sakofsky, C.J., Ayyar, S., Deem, A.K., Chung, W.-H., Ira, G., Malkova, A., Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements. Mol. Cell 60 (2015), 860–872.
-
(2015)
Mol. Cell
, vol.60
, pp. 860-872
-
-
Sakofsky, C.J.1
Ayyar, S.2
Deem, A.K.3
Chung, W.-H.4
Ira, G.5
Malkova, A.6
-
22
-
-
84945916597
-
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
-
Sfeir, A., Symington, L.S., Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?. Trends Biochem. Sci. 40 (2015), 701–714.
-
(2015)
Trends Biochem. Sci.
, vol.40
, pp. 701-714
-
-
Sfeir, A.1
Symington, L.S.2
-
23
-
-
0037356808
-
Phenotype-based identification of mouse chromosome instability mutants
-
Shima, N., Hartford, S.A., Duffy, T., Wilson, L.A., Schimenti, K.J., Schimenti, J.C., Phenotype-based identification of mouse chromosome instability mutants. Genetics 163 (2003), 1031–1040.
-
(2003)
Genetics
, vol.163
, pp. 1031-1040
-
-
Shima, N.1
Hartford, S.A.2
Duffy, T.3
Wilson, L.A.4
Schimenti, K.J.5
Schimenti, J.C.6
-
24
-
-
8644233355
-
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm
-
Shima, N., Munroe, R.J., Schimenti, J.C., The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Mol. Cell. Biol. 24 (2004), 10381–10389.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10381-10389
-
-
Shima, N.1
Munroe, R.J.2
Schimenti, J.C.3
-
25
-
-
77950462986
-
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation
-
Simsek, D., Jasin, M., Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat. Struct. Mol. Biol. 17 (2010), 410–416.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 410-416
-
-
Simsek, D.1
Jasin, M.2
-
26
-
-
84935856905
-
Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis
-
van Schendel, R., Roerink, S.F., Portegijs, V., van den Heuvel, S., Tijsterman, M., Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis. Nat. Commun., 6, 2015, 7394.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7394
-
-
van Schendel, R.1
Roerink, S.F.2
Portegijs, V.3
van den Heuvel, S.4
Tijsterman, M.5
-
27
-
-
34547589577
-
Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
-
Weinstock, D.M., Brunet, E., Jasin, M., Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat. Cell Biol. 9 (2007), 978–981.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 978-981
-
-
Weinstock, D.M.1
Brunet, E.2
Jasin, M.3
-
28
-
-
84871715412
-
DNA polymerase POLQ and cellular defense against DNA damage
-
Yousefzadeh, M.J., Wood, R.D., DNA polymerase POLQ and cellular defense against DNA damage. DNA Repair (Amst.) 12 (2013), 1–9.
-
(2013)
DNA Repair (Amst.)
, vol.12
, pp. 1-9
-
-
Yousefzadeh, M.J.1
Wood, R.D.2
-
29
-
-
84908326310
-
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ
-
Yousefzadeh, M.J., Wyatt, D.W., Takata, K., Mu, Y., Hensley, S.C., Tomida, J., Bylund, G.O., Doublié, S., Johansson, E., Ramsden, D.A., et al. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet., 10, 2014, e1004654.
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004654
-
-
Yousefzadeh, M.J.1
Wyatt, D.W.2
Takata, K.3
Mu, Y.4
Hensley, S.C.5
Tomida, J.6
Bylund, G.O.7
Doublié, S.8
Johansson, E.9
Ramsden, D.A.10
-
30
-
-
84926330291
-
Human DNA polymerase θ grasps the primer terminus to mediate DNA repair
-
Zahn, K.E., Averill, A.M., Aller, P., Wood, R.D., Doublié, S., Human DNA polymerase θ grasps the primer terminus to mediate DNA repair. Nat. Struct. Mol. Biol. 22 (2015), 304–311.
-
(2015)
Nat. Struct. Mol. Biol.
, vol.22
, pp. 304-311
-
-
Zahn, K.E.1
Averill, A.M.2
Aller, P.3
Wood, R.D.4
Doublié, S.5
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