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Volumn 276, Issue 1, 2017, Pages 192-212

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

Author keywords

co inhibitory blockade; co stimulation blockade; transplantation

Indexed keywords

ABATACEPT; CD2 ANTIGEN; CD28 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; OX40 LIGAND; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

EID: 85014412248     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12523     Document Type: Review
Times cited : (40)

References (338)
  • 1
    • 0027451441 scopus 로고
    • Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
    • Lin H, Bolling SF, Linsley PS, et al. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med. 1993;178:1801–1806.
    • (1993) J Exp Med , vol.178 , pp. 1801-1806
    • Lin, H.1    Bolling, S.F.2    Linsley, P.S.3
  • 2
    • 0026778697 scopus 로고
    • Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule
    • Linsley PS, Wallace PM, Johnson J, et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science. 1992;257:792–795.
    • (1992) Science , vol.257 , pp. 792-795
    • Linsley, P.S.1    Wallace, P.M.2    Johnson, J.3
  • 3
    • 0026738641 scopus 로고
    • Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg
    • Lenschow DJ, Zeng Y, Thistlethwaite JR, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg. Science. 1992;257:789–792.
    • (1992) Science , vol.257 , pp. 789-792
    • Lenschow, D.J.1    Zeng, Y.2    Thistlethwaite, J.R.3
  • 5
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996;381:434–438.
    • (1996) Nature , vol.381 , pp. 434-438
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 7
    • 0025322552 scopus 로고
    • T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
    • Linsley PS, Clark EA, Ledbetter JA. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci USA. 1990;87:5031–5035.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5031-5035
    • Linsley, P.S.1    Clark, E.A.2    Ledbetter, J.A.3
  • 8
    • 0024444165 scopus 로고
    • B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
    • Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989;143:2714–2722.
    • (1989) J Immunol , vol.143 , pp. 2714-2722
    • Freeman, G.J.1    Freedman, A.S.2    Segil, J.M.3    Lee, G.4    Whitman, J.F.5    Nadler, L.M.6
  • 9
    • 0025947446 scopus 로고
    • B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
    • Gimmi CD, Freeman GJ, Gribben JG, et al. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci USA. 1991;88:6575–6579.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6575-6579
    • Gimmi, C.D.1    Freeman, G.J.2    Gribben, J.G.3
  • 10
    • 0027767762 scopus 로고
    • Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
    • Freeman GJ, Gribben JG, Boussiotis VA, et al. Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993;262:909–911.
    • (1993) Science , vol.262 , pp. 909-911
    • Freeman, G.J.1    Gribben, J.G.2    Boussiotis, V.A.3
  • 11
    • 0027437391 scopus 로고
    • Expression and functional significance of an additional ligand for CTLA-4
    • Lenschow DJ, Su GH, Zuckerman LA, et al. Expression and functional significance of an additional ligand for CTLA-4. Proc Natl Acad Sci USA. 1993;90:11054–11058.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11054-11058
    • Lenschow, D.J.1    Su, G.H.2    Zuckerman, L.A.3
  • 12
    • 0027937702 scopus 로고
    • Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
    • Peach RJ, Bajorath J, Brady W, et al. Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1. J Exp Med. 1994;180:2049–2058.
    • (1994) J Exp Med , vol.180 , pp. 2049-2058
    • Peach, R.J.1    Bajorath, J.2    Brady, W.3
  • 13
    • 0023270567 scopus 로고
    • A new member of the immunoglobulin superfamily–CTLA-4
    • Brunet JF, Denizot F, Luciani MF, et al. A new member of the immunoglobulin superfamily–CTLA-4. Nature. 1987;328:267–270.
    • (1987) Nature , vol.328 , pp. 267-270
    • Brunet, J.F.1    Denizot, F.2    Luciani, M.F.3
  • 14
    • 0025735829 scopus 로고
    • CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location
    • Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF, Golstein P. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J Immunol. 1991;147:1037–1044.
    • (1991) J Immunol , vol.147 , pp. 1037-1044
    • Harper, K.1    Balzano, C.2    Rouvier, E.3    Mattei, M.G.4    Luciani, M.F.5    Golstein, P.6
  • 15
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas TL, Lenschow DJ, Bakker CY, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994;1:405–413.
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1    Lenschow, D.J.2    Bakker, C.Y.3
  • 16
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995;182:459–465.
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 17
    • 0026459468 scopus 로고
    • T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo
    • Turka LA, Linsley PS, Lin H, et al. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc Natl Acad Sci USA. 1992;89:11102–11105.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11102-11105
    • Turka, L.A.1    Linsley, P.S.2    Lin, H.3
  • 18
    • 0028483990 scopus 로고
    • Treatment of murine lupus with CTLA4Ig
    • Finck BK, Linsley PS, Wofsy D. Treatment of murine lupus with CTLA4Ig. Science. 1994;265:1225–1227.
    • (1994) Science , vol.265 , pp. 1225-1227
    • Finck, B.K.1    Linsley, P.S.2    Wofsy, D.3
  • 19
    • 0029162499 scopus 로고
    • Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig
    • Knoerzer DB, Karr RW, Schwartz BD, Mengle-Gaw LJ. Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. J Clin Invest. 1995;96:987–993.
    • (1995) J Clin Invest , vol.96 , pp. 987-993
    • Knoerzer, D.B.1    Karr, R.W.2    Schwartz, B.D.3    Mengle-Gaw, L.J.4
  • 20
    • 0028785417 scopus 로고
    • Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis
    • Racke MK, Scott DE, Quigley L, et al. Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. J Clin Invest. 1995;96:2195–2203.
    • (1995) J Clin Invest , vol.96 , pp. 2195-2203
    • Racke, M.K.1    Scott, D.E.2    Quigley, L.3
  • 21
    • 0033135564 scopus 로고    scopus 로고
    • CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris
    • Abrams JR, Lebwohl MG, Guzzo CA, et al. CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest. 1999;103:1243–1252.
    • (1999) J Clin Invest , vol.103 , pp. 1243-1252
    • Abrams, J.R.1    Lebwohl, M.G.2    Guzzo, C.A.3
  • 22
    • 0036275436 scopus 로고    scopus 로고
    • Costimulatory blockade in patients with rheumatoid arthritis: A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion
    • Moreland LW, Alten R, Van den Bosch F, et al. Costimulatory blockade in patients with rheumatoid arthritis: A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum. 2002;46:1470–1479.
    • (2002) Arthritis Rheum , vol.46 , pp. 1470-1479
    • Moreland, L.W.1    Alten, R.2    Van den Bosch, F.3
  • 23
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Kremer JM, Westhovens R, Leon M, et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med. 2003;349:1907–1915.
    • (2003) N Engl J Med , vol.349 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3
  • 24
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
    • Genovese MC, Becker JC, Schiff M, et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med. 2005;353:1114–1123.
    • (2005) N Engl J Med , vol.353 , pp. 1114-1123
    • Genovese, M.C.1    Becker, J.C.2    Schiff, M.3
  • 25
    • 23644455857 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial
    • Kremer JM, Dougados M, Emery P, et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 2005;52:2263–2271.
    • (2005) Arthritis Rheum , vol.52 , pp. 2263-2271
    • Kremer, J.M.1    Dougados, M.2    Emery, P.3
  • 26
    • 33745291091 scopus 로고    scopus 로고
    • Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: A randomized trial
    • Kremer JM, Genant HK, Moreland LW, et al. Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: A randomized trial. Ann Intern Med. 2006;144:865–876.
    • (2006) Ann Intern Med , vol.144 , pp. 865-876
    • Kremer, J.M.1    Genant, H.K.2    Moreland, L.W.3
  • 27
    • 54049093695 scopus 로고    scopus 로고
    • CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial
    • Viglietta V, Bourcier K, Buckle GJ, et al. CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial. Neurology. 2008;71:917–924.
    • (2008) Neurology , vol.71 , pp. 917-924
    • Viglietta, V.1    Bourcier, K.2    Buckle, G.J.3
  • 28
    • 84875167845 scopus 로고    scopus 로고
    • A randomized controlled trial to evaluate inhibition of T-cell costimulation in allergen-induced airway inflammation
    • Parulekar AD, Boomer JS, Patterson BM, et al. A randomized controlled trial to evaluate inhibition of T-cell costimulation in allergen-induced airway inflammation. Am J Respir Crit Care Med. 2013;187:494–501.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 494-501
    • Parulekar, A.D.1    Boomer, J.S.2    Patterson, B.M.3
  • 29
    • 79960912796 scopus 로고    scopus 로고
    • Co-stimulation modulation with abatacept in patients with recentonset type 1 diabetes: A randomised, double-blind, placebo-controlled trial
    • Orban T, Bundy B, Becker DJ, et al. Type 1 Diabetes TrialNet Abatacept Study Group. Co-stimulation modulation with abatacept in patients with recentonset type 1 diabetes: A randomised, double-blind, placebo-controlled trial. Lancet. 2011;378:412–419.
    • (2011) Lancet , vol.378 , pp. 412-419
    • Orban, T.1    Bundy, B.2    Becker, D.J.3
  • 30
    • 84862741536 scopus 로고    scopus 로고
    • Abatacept for Crohn's disease and ulcerative colitis
    • Sandborn WJ, Colombel JF, Sands BE, et al. Abatacept for Crohn's disease and ulcerative colitis. Gastroenterology. 2012;143(62–9):e4.
    • (2012) Gastroenterology , vol.143 , Issue.62-9
    • Sandborn, W.J.1    Colombel, J.F.2    Sands, B.E.3
  • 31
    • 77957682858 scopus 로고    scopus 로고
    • The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial
    • Merrill JT, Burgos-Vargas R, Westhovens R, et al. The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2010;62:3077–3087.
    • (2010) Arthritis Rheum , vol.62 , pp. 3077-3087
    • Merrill, J.T.1    Burgos-Vargas, R.2    Westhovens, R.3
  • 32
    • 0028234261 scopus 로고
    • In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice
    • Blazar BR, Taylor PA, Linsley PS, Vallera DA. In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice. Blood. 1994;83:3815–3825.
    • (1994) Blood , vol.83 , pp. 3815-3825
    • Blazar, B.R.1    Taylor, P.A.2    Linsley, P.S.3    Vallera, D.A.4
  • 33
    • 78650070717 scopus 로고    scopus 로고
    • + T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression
    • + T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression. Blood. 2010;116:5403–5418.
    • (2010) Blood , vol.116 , pp. 5403-5418
    • Miller, W.P.1    Srinivasan, S.2    Panoskaltsis-Mortari, A.3
  • 34
    • 0032080384 scopus 로고    scopus 로고
    • Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28
    • Saito K, Sakurai J, Ohata J, et al. Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogeneic T cells lacking CD28. J Immunol. 1998;160:4225–4231.
    • (1998) J Immunol , vol.160 , pp. 4225-4231
    • Saito, K.1    Sakurai, J.2    Ohata, J.3
  • 35
    • 0029125813 scopus 로고
    • Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules
    • Hakim FT, Cepeda R, Gray GS, June CH, Abe R. Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules. J Immunol. 1995;155:1757–1766.
    • (1995) J Immunol , vol.155 , pp. 1757-1766
    • Hakim, F.T.1    Cepeda, R.2    Gray, G.S.3    June, C.H.4    Abe, R.5
  • 36
    • 0028124625 scopus 로고
    • CTLA4Ig treatment ameliorates the lethality of murine graft-versus-host disease across major histocompatibility complex barriers
    • Wallace PM, Johnson JS, MacMaster JF, Kennedy KA, Gladstone P, Linsley PS. CTLA4Ig treatment ameliorates the lethality of murine graft-versus-host disease across major histocompatibility complex barriers. Transplantation. 1994;58:602–610.
    • (1994) Transplantation , vol.58 , pp. 602-610
    • Wallace, P.M.1    Johnson, J.S.2    MacMaster, J.F.3    Kennedy, K.A.4    Gladstone, P.5    Linsley, P.S.6
  • 37
    • 0030293633 scopus 로고    scopus 로고
    • Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD
    • Via CS, Rus V, Nguyen P, Linsley P, Gause WC. Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD. J Immunol. 1996;157:4258–4267.
    • (1996) J Immunol , vol.157 , pp. 4258-4267
    • Via, C.S.1    Rus, V.2    Nguyen, P.3    Linsley, P.4    Gause, W.C.5
  • 38
    • 84885796022 scopus 로고    scopus 로고
    • In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: A first-in-disease trial
    • Koura DT, Horan JT, Langston AA, et al. In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: A first-in-disease trial. Biol Blood Marrow Transplant. 2013;19:1638–1649.
    • (2013) Biol Blood Marrow Transplant , vol.19 , pp. 1638-1649
    • Koura, D.T.1    Horan, J.T.2    Langston, A.A.3
  • 39
    • 33947329800 scopus 로고    scopus 로고
    • CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase
    • Pree I, Bigenzahn S, Fuchs D, et al. CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase. Transplantation. 2007;83:663–667.
    • (2007) Transplantation , vol.83 , pp. 663-667
    • Pree, I.1    Bigenzahn, S.2    Fuchs, D.3
  • 40
    • 23044482250 scopus 로고    scopus 로고
    • Shortterm immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning
    • Blaha P, Bigenzahn S, Koporc Z, Sykes M, Muehlbacher F, Wekerle T. Shortterm immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning. Transplantation. 2005;80:237–243.
    • (2005) Transplantation , vol.80 , pp. 237-243
    • Blaha, P.1    Bigenzahn, S.2    Koporc, Z.3    Sykes, M.4    Muehlbacher, F.5    Wekerle, T.6
  • 41
    • 0036773925 scopus 로고    scopus 로고
    • Mechanisms of transplant tolerance induction using costimulatory blockade
    • Wekerle T, Kurtz J, Bigenzahn S, Takeuchi Y, Sykes M. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol. 2002;14:592–600.
    • (2002) Curr Opin Immunol , vol.14 , pp. 592-600
    • Wekerle, T.1    Kurtz, J.2    Bigenzahn, S.3    Takeuchi, Y.4    Sykes, M.5
  • 42
    • 0035865066 scopus 로고    scopus 로고
    • Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death
    • Wekerle T, Kurtz J, Sayegh M, et al. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol. 2001;166:2311–2316.
    • (2001) J Immunol , vol.166 , pp. 2311-2316
    • Wekerle, T.1    Kurtz, J.2    Sayegh, M.3
  • 43
    • 0034071426 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
    • Wekerle T, Kurtz J, Ito H, et al. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med. 2000;6:464–469.
    • (2000) Nat Med , vol.6 , pp. 464-469
    • Wekerle, T.1    Kurtz, J.2    Ito, H.3
  • 44
    • 0033571542 scopus 로고    scopus 로고
    • Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance
    • Wekerle T, Sayegh MH, Ito H, et al. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation. 1999;68:1348–1355.
    • (1999) Transplantation , vol.68 , pp. 1348-1355
    • Wekerle, T.1    Sayegh, M.H.2    Ito, H.3
  • 45
    • 0032526283 scopus 로고    scopus 로고
    • Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance
    • Wekerle T, Sayegh MH, Hill J, et al. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med. 1998;187:2037–2044.
    • (1998) J Exp Med , vol.187 , pp. 2037-2044
    • Wekerle, T.1    Sayegh, M.H.2    Hill, J.3
  • 46
    • 0035879193 scopus 로고    scopus 로고
    • Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression
    • Adams AB, Durham MM, Kean L, et al. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. J Immunol. 2001;167:1103–1111.
    • (2001) J Immunol , vol.167 , pp. 1103-1111
    • Adams, A.B.1    Durham, M.M.2    Kean, L.3
  • 48
    • 0036061575 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates
    • Adams AB, Shirasugi N, Durham MM, et al. Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes. 2002;51:265–270.
    • (2002) Diabetes , vol.51 , pp. 265-270
    • Adams, A.B.1    Shirasugi, N.2    Durham, M.M.3
  • 49
    • 0034235458 scopus 로고    scopus 로고
    • Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
    • Durham MM, Bingaman AW, Adams AB, et al. Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol. 2000;165:1–4.
    • (2000) J Immunol , vol.165 , pp. 1-4
    • Durham, M.M.1    Bingaman, A.W.2    Adams, A.B.3
  • 50
    • 0036493491 scopus 로고    scopus 로고
    • A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation
    • Kean LS, Durham MM, Adams AB, et al. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood. 2002;99:1840–1849.
    • (2002) Blood , vol.99 , pp. 1840-1849
    • Kean, L.S.1    Durham, M.M.2    Adams, A.B.3
  • 51
    • 10744229369 scopus 로고    scopus 로고
    • Chimerism and cure: Hematologic and pathologic correction of murine sickle cell disease
    • Kean LS, Manci EA, Perry J, et al. Chimerism and cure: Hematologic and pathologic correction of murine sickle cell disease. Blood. 2003;102:4582–4593.
    • (2003) Blood , vol.102 , pp. 4582-4593
    • Kean, L.S.1    Manci, E.A.2    Perry, J.3
  • 52
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a highaffinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Larsen CP, Pearson TC, Adams AB, et al. Rational development of LEA29Y (belatacept), a highaffinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant. 2005;5:443–453.
    • (2005) Am J Transplant , vol.5 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 53
    • 0031307384 scopus 로고    scopus 로고
    • Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation
    • Levisetti MG, Padrid PA, Szot GL, et al. Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J Immunol. 1997;159:5187–5191.
    • (1997) J Immunol , vol.159 , pp. 5187-5191
    • Levisetti, M.G.1    Padrid, P.A.2    Szot, G.L.3
  • 54
    • 23944502334 scopus 로고    scopus 로고
    • Costimulation blockade with belatacept in renal transplantation
    • Vincenti F, Larsen C, Durrbach A, et al. Belatacept Study Group. Costimulation blockade with belatacept in renal transplantation. N Engl J Med. 2005;353:770–781.
    • (2005) N Engl J Med , vol.353 , pp. 770-781
    • Vincenti, F.1    Larsen, C.2    Durrbach, A.3
  • 55
    • 84955444904 scopus 로고    scopus 로고
    • Belatacept and long-term outcomes in kidney transplantation
    • Vincenti F, Rostaing L, Grinyo J, et al. Belatacept and long-term outcomes in kidney transplantation. N Engl J Med. 2016;374:333–343.
    • (2016) N Engl J Med , vol.374 , pp. 333-343
    • Vincenti, F.1    Rostaing, L.2    Grinyo, J.3
  • 56
    • 84886791910 scopus 로고    scopus 로고
    • Long-term belatacept exposure maintains efficacy and safety at 5 years: Results from the long-term extension of the BENEFIT study
    • Rostaing L, Vincenti F, Grinyo J, et al. Long-term belatacept exposure maintains efficacy and safety at 5 years: Results from the long-term extension of the BENEFIT study. Am J Transplant. 2013;13:2875–2883.
    • (2013) Am J Transplant , vol.13 , pp. 2875-2883
    • Rostaing, L.1    Vincenti, F.2    Grinyo, J.3
  • 57
    • 79955544132 scopus 로고    scopus 로고
    • Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies)
    • Vanrenterghem Y, Bresnahan B, Campistol J, et al. Belatacept-based regimens are associated with improved cardiovascular and metabolic risk factors compared with cyclosporine in kidney transplant recipients (BENEFIT and BENEFIT-EXT studies). Transplantation. 2011;91:976–983.
    • (2011) Transplantation , vol.91 , pp. 976-983
    • Vanrenterghem, Y.1    Bresnahan, B.2    Campistol, J.3
  • 58
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995;3:541–547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 59
    • 0033770215 scopus 로고    scopus 로고
    • CD28, CTLA-4 and their ligands: Who does what and to whom?
    • Sansom DM. CD28, CTLA-4 and their ligands: Who does what and to whom? Immunology. 2000;101:169–177.
    • (2000) Immunology , vol.101 , pp. 169-177
    • Sansom, D.M.1
  • 60
    • 59849085140 scopus 로고    scopus 로고
    • Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity
    • Schmidt EM, Wang CJ, Ryan GA, et al. Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. J Immunol. 2009;182:274–282.
    • (2009) J Immunol , vol.182 , pp. 274-282
    • Schmidt, E.M.1    Wang, C.J.2    Ryan, G.A.3
  • 62
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 1995;270:985–988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 65
    • 51849108540 scopus 로고    scopus 로고
    • The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation
    • Bluestone JA, Liu W, Yabu JM, et al. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am J Transplant. 2008;8:2086–2096.
    • (2008) Am J Transplant , vol.8 , pp. 2086-2096
    • Bluestone, J.A.1    Liu, W.2    Yabu, J.M.3
  • 66
    • 84862784932 scopus 로고    scopus 로고
    • Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model
    • Riella LV, Liu T, Yang J, et al. Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model. Am J Transplant. 2012;12:846–855.
    • (2012) Am J Transplant , vol.12 , pp. 846-855
    • Riella, L.V.1    Liu, T.2    Yang, J.3
  • 67
    • 84988569115 scopus 로고    scopus 로고
    • The knife's edge of tolerance: Inducing stable multilineage mixed chimerism but with a significant risk of CMV reactivation and disease in rhesus macaques
    • Zheng HB, Watkins B, Tkachev V, et al. The knife's edge of tolerance: Inducing stable multilineage mixed chimerism but with a significant risk of CMV reactivation and disease in rhesus macaques. Am J Transplant. 2016; doi:10.1111/ajt.14006.
    • (2016) Am J Transplant
    • Zheng, H.B.1    Watkins, B.2    Tkachev, V.3
  • 68
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med. 2006;355:1018–1028.
    • (2006) N Engl J Med , vol.355 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 69
    • 33750608522 scopus 로고    scopus 로고
    • Lessons from TGN1412
    • author reply 70
    • Hanke T. Lessons from TGN1412. Lancet. 2006;368:1569–1570; author reply 70.
    • (2006) Lancet , vol.368 , pp. 1569-1570
    • Hanke, T.1
  • 70
    • 84886035929 scopus 로고    scopus 로고
    • A monovalent anti-human CD28 domain antibody antagonist: Preclinical efficacy and safety
    • Suchard SJ, Davis PM, Kansal S, et al. A monovalent anti-human CD28 domain antibody antagonist: Preclinical efficacy and safety. J Immunol. 2013;191:4599–4610.
    • (2013) J Immunol , vol.191 , pp. 4599-4610
    • Suchard, S.J.1    Davis, P.M.2    Kansal, S.3
  • 71
    • 84939184953 scopus 로고    scopus 로고
    • + T cell responses by selective CD28 blockade is independent of reduced ICOS expression
    • + T cell responses by selective CD28 blockade is independent of reduced ICOS expression. PLoS ONE. 2015;10:e0130490.
    • (2015) PLoS ONE , vol.10
    • Liu, D.1    Suchard, S.J.2    Nadler, S.G.3    Ford, M.L.4
  • 73
    • 84992455365 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and safety profile of a novel anti-CD28 domain antibody antagonist in healthy subjects
    • Shi R, Honczarenko M, Zhang S, et al. Pharmacokinetic, pharmacodynamic, and safety profile of a novel anti-CD28 domain antibody antagonist in healthy subjects. J Clin Pharmacol. 2016; doi:10.1002/jcph.791.
    • (2016) J Clin Pharmacol
    • Shi, R.1    Honczarenko, M.2    Zhang, S.3
  • 74
    • 84966290861 scopus 로고    scopus 로고
    • Integrated pharmacokinetic/pharmacodynamic analysis for determining the minimal anticipated biological effect level of a novel anti-CD28 receptor antagonist BMS-931699
    • Yang Z, Wang H, Salcedo TW, et al. Integrated pharmacokinetic/pharmacodynamic analysis for determining the minimal anticipated biological effect level of a novel anti-CD28 receptor antagonist BMS-931699. J Pharmacol Exp Ther. 2015;355:506–515.
    • (2015) J Pharmacol Exp Ther , vol.355 , pp. 506-515
    • Yang, Z.1    Wang, H.2    Salcedo, T.W.3
  • 75
    • 84872839388 scopus 로고    scopus 로고
    • Antagonist properties of monoclonal antibodies targeting human CD28: Role of valency and the heavy-chain constant domain
    • Mary C, Coulon F, Poirier N, et al. Antagonist properties of monoclonal antibodies targeting human CD28: Role of valency and the heavy-chain constant domain. mAbs. 2013;5:47–55.
    • (2013) mAbs , vol.5 , pp. 47-55
    • Mary, C.1    Coulon, F.2    Poirier, N.3
  • 76
    • 84867098490 scopus 로고    scopus 로고
    • Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab’ antibody
    • Poirier N, Mary C, Dilek N, et al. Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab’ antibody. Am J Transplant. 2012;12:2630–2640.
    • (2012) Am J Transplant , vol.12 , pp. 2630-2640
    • Poirier, N.1    Mary, C.2    Dilek, N.3
  • 77
    • 84919622359 scopus 로고    scopus 로고
    • FR104, an antagonist anti-CD28 monovalent fab’ antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal allograft
    • Poirier N, Dilek N, Mary C, et al. FR104, an antagonist anti-CD28 monovalent fab’ antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal allograft. Am J Transplant. 2015;15:88–100.
    • (2015) Am J Transplant , vol.15 , pp. 88-100
    • Poirier, N.1    Dilek, N.2    Mary, C.3
  • 78
    • 84958876635 scopus 로고    scopus 로고
    • Clinical efficacy of a new CD28-targeting antagonist of T cell co-stimulation in a nonhuman primate model of collagen-induced arthritis
    • Vierboom MP, Breedveld E, Kap YS, et al. Clinical efficacy of a new CD28-targeting antagonist of T cell co-stimulation in a nonhuman primate model of collagen-induced arthritis. Clin Exp Immunol. 2016;183:405–418.
    • (2016) Clin Exp Immunol , vol.183 , pp. 405-418
    • Vierboom, M.P.1    Breedveld, E.2    Kap, Y.S.3
  • 79
    • 84922569652 scopus 로고    scopus 로고
    • Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis
    • Haanstra KG, Dijkman K, Bashir N, et al. Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis. J Immunol. 2015;194:1454–1466.
    • (2015) J Immunol , vol.194 , pp. 1454-1466
    • Haanstra, K.G.1    Dijkman, K.2    Bashir, N.3
  • 80
    • 85017191641 scopus 로고    scopus 로고
    • Anti-CD28 antibody and belatacept exert differential effects on mechanisms of renal allograft rejection
    • Ville S, Poirier N, Branchereau J, et al. Anti-CD28 antibody and belatacept exert differential effects on mechanisms of renal allograft rejection. J Am Soc Nephrol. 2016; doi:10.1681/ASN.2015070774.
    • (2016) J Am Soc Nephrol
    • Ville, S.1    Poirier, N.2    Branchereau, J.3
  • 81
    • 84986199043 scopus 로고    scopus 로고
    • Preclinical testing of anti-human CD28 Fab’ antibody in a novel nonhuman primate (NHP) small animal rodent model of xenogenic graft-versus-host disease (GVHD)
    • Hippen KL, Watkins B, Tkachev V, et al. Preclinical testing of anti-human CD28 Fab’ antibody in a novel nonhuman primate (NHP) small animal rodent model of xenogenic graft-versus-host disease (GVHD). Transplantation. 2016; doi:10.1097/TP.0000000000001465.
    • (2016) Transplantation
    • Hippen, K.L.1    Watkins, B.2    Tkachev, V.3
  • 83
    • 0033520080 scopus 로고    scopus 로고
    • High-affinity interactions of tumor necrosis factor receptorassociated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization
    • Pullen SS, Labadia ME, Ingraham RH, et al. High-affinity interactions of tumor necrosis factor receptorassociated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization. Biochemistry. 1999;38:10168–10177.
    • (1999) Biochemistry , vol.38 , pp. 10168-10177
    • Pullen, S.S.1    Labadia, M.E.2    Ingraham, R.H.3
  • 84
    • 0027493906 scopus 로고
    • In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39
    • Foy TM, Shepherd DM, Durie FH, Aruffo A, Ledbetter JA, Noelle RJ. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J Exp Med. 1993;178:1567–1575.
    • (1993) J Exp Med , vol.178 , pp. 1567-1575
    • Foy, T.M.1    Shepherd, D.M.2    Durie, F.H.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 85
    • 0027373275 scopus 로고
    • In vivo CD40-gp39 interactions are essential for thymusdependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions
    • Van den Eertwegh AJ, Noelle RJ, Roy M, et al. In vivo CD40-gp39 interactions are essential for thymusdependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J Exp Med. 1993;178:1555–1565.
    • (1993) J Exp Med , vol.178 , pp. 1555-1565
    • Van den Eertwegh, A.J.1    Noelle, R.J.2    Roy, M.3
  • 86
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    • Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA. 1996;93:13967–13972.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13967-13972
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.G.3    Peach, R.4    Linsley, P.S.5    Turka, L.A.6
  • 87
    • 0030046808 scopus 로고    scopus 로고
    • CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway
    • Larsen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation. 1996;61:4–9.
    • (1996) Transplantation , vol.61 , pp. 4-9
    • Larsen, C.P.1    Alexander, D.Z.2    Hollenbaugh, D.3
  • 89
    • 4344586455 scopus 로고    scopus 로고
    • CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates
    • Kawai T, Sogawa H, Boskovic S, et al. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant. 2004;4:1391–1398.
    • (2004) Am J Transplant , vol.4 , pp. 1391-1398
    • Kawai, T.1    Sogawa, H.2    Boskovic, S.3
  • 90
    • 2542450949 scopus 로고    scopus 로고
    • Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: Evidence for anergy and deletion but not regulatory cells
    • Kurtz J, Shaffer J, Lie A, Anosova N, Benichou G, Sykes M. Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: Evidence for anergy and deletion but not regulatory cells. Blood. 2004;103:4336–4343.
    • (2004) Blood , vol.103 , pp. 4336-4343
    • Kurtz, J.1    Shaffer, J.2    Lie, A.3    Anosova, N.4    Benichou, G.5    Sykes, M.6
  • 91
    • 0032533476 scopus 로고    scopus 로고
    • The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo
    • Niimi M, Pearson TC, Larsen CP, et al. The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo. J Immunol. 1998;161:5331–5337.
    • (1998) J Immunol , vol.161 , pp. 5331-5337
    • Niimi, M.1    Pearson, T.C.2    Larsen, C.P.3
  • 92
    • 0035880243 scopus 로고    scopus 로고
    • Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions
    • Taylor PA, Lees CJ, Waldmann H, Noelle RJ, Blazar BR. Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions. Blood. 2001;98:467–474.
    • (2001) Blood , vol.98 , pp. 467-474
    • Taylor, P.A.1    Lees, C.J.2    Waldmann, H.3    Noelle, R.J.4    Blazar, B.R.5
  • 93
    • 0032146529 scopus 로고    scopus 로고
    • CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versushost disease lethality capacity but retain nominal antigen responses
    • Blazar BR, Taylor PA, Noelle RJ, Vallera DA. CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versushost disease lethality capacity but retain nominal antigen responses. J Clin Invest. 1998;102:473–482.
    • (1998) J Clin Invest , vol.102 , pp. 473-482
    • Blazar, B.R.1    Taylor, P.A.2    Noelle, R.J.3    Vallera, D.A.4
  • 94
    • 0030639082 scopus 로고    scopus 로고
    • + T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation
    • + T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation. J Immunol. 1997;158:29–39.
    • (1997) J Immunol , vol.158 , pp. 29-39
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3
  • 95
    • 25444485654 scopus 로고    scopus 로고
    • Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis
    • Smook ML, Heeringa P, Damoiseaux JG, et al. Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis. Atherosclerosis. 2005;183:275–282.
    • (2005) Atherosclerosis , vol.183 , pp. 275-282
    • Smook, M.L.1    Heeringa, P.2    Damoiseaux, J.G.3
  • 98
  • 100
    • 84886769415 scopus 로고    scopus 로고
    • An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig
    • Pinelli DF, Wagener ME, Liu D, et al. An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig. Am J Transplant. 2013;13:3021–3030.
    • (2013) Am J Transplant , vol.13 , pp. 3021-3030
    • Pinelli, D.F.1    Wagener, M.E.2    Liu, D.3
  • 101
    • 61949334905 scopus 로고    scopus 로고
    • Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    • Zhang N, Schroppel B, Lal G, et al. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity. 2009;30:458–469.
    • (2009) Immunity , vol.30 , pp. 458-469
    • Zhang, N.1    Schroppel, B.2    Lal, G.3
  • 102
    • 78349239341 scopus 로고    scopus 로고
    • An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching
    • Larsen CP, Page A, Linzie KH, et al. An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching. Am J Transplant. 2010;10:2396–2409.
    • (2010) Am J Transplant , vol.10 , pp. 2396-2409
    • Larsen, C.P.1    Page, A.2    Linzie, K.H.3
  • 103
    • 84890894235 scopus 로고    scopus 로고
    • Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection
    • Kim EJ, Kwun J, Gibby AC, et al. Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. Am J Transplant. 2014;14:59–69.
    • (2014) Am J Transplant , vol.14 , pp. 59-69
    • Kim, E.J.1    Kwun, J.2    Gibby, A.C.3
  • 104
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk AD, Burkly LC, Batty DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med. 1999;5:686–693.
    • (1999) Nat Med , vol.5 , pp. 686-693
    • Kirk, A.D.1    Burkly, L.C.2    Batty, D.S.3
  • 105
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA. 1997;94:8789–8794.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8789-8794
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 106
    • 0037109144 scopus 로고    scopus 로고
    • Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells
    • May AE, Kalsch T, Massberg S, Herouy Y, Schmidt R, Gawaz M. Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation. 2002;106:2111–2117.
    • (2002) Circulation , vol.106 , pp. 2111-2117
    • May, A.E.1    Kalsch, T.2    Massberg, S.3    Herouy, Y.4    Schmidt, R.5    Gawaz, M.6
  • 107
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • Henn V, Slupsky JR, Grafe M, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 1998;391:591–594.
    • (1998) Nature , vol.391 , pp. 591-594
    • Henn, V.1    Slupsky, J.R.2    Grafe, M.3
  • 108
    • 84868193077 scopus 로고    scopus 로고
    • Platelet-derived CD154: Ultrastructural localization and clinical correlation in organ transplantation
    • Charafeddine AH, Kim EJ, Maynard DM, et al. Platelet-derived CD154: Ultrastructural localization and clinical correlation in organ transplantation. Am J Transplant. 2012;12:3143–3151.
    • (2012) Am J Transplant , vol.12 , pp. 3143-3151
    • Charafeddine, A.H.1    Kim, E.J.2    Maynard, D.M.3
  • 109
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
    • Kawai T, Andrews D, Colvin RB, Sachs DH, Cosimi AB. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med. 2000;6:114.
    • (2000) Nat Med , vol.6 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3    Sachs, D.H.4    Cosimi, A.B.5
  • 110
    • 84855981278 scopus 로고    scopus 로고
    • Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates
    • Badell IR, Thompson PW, Turner AP, et al. Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates. Am J Transplant. 2012;12:126–135.
    • (2012) Am J Transplant , vol.12 , pp. 126-135
    • Badell, I.R.1    Thompson, P.W.2    Turner, A.P.3
  • 111
    • 68149165399 scopus 로고    scopus 로고
    • Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation
    • Gilson CR, Milas Z, Gangappa S, et al. Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation. J Immunol. 2009;183:1625–1635.
    • (2009) J Immunol , vol.183 , pp. 1625-1635
    • Gilson, C.R.1    Milas, Z.2    Gangappa, S.3
  • 112
    • 84864478677 scopus 로고    scopus 로고
    • A novel monoclonal antibody to CD40 prolongs islet allograft survival
    • Lowe M, Badell IR, Thompson P, et al. A novel monoclonal antibody to CD40 prolongs islet allograft survival. Am J Transplant. 2012;12:2079–2087.
    • (2012) Am J Transplant , vol.12 , pp. 2079-2087
    • Lowe, M.1    Badell, I.R.2    Thompson, P.3
  • 113
    • 0035159495 scopus 로고    scopus 로고
    • Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models
    • Rothstein DM, Livak MF, Kishimoto K, et al. Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models. J Immunol. 2001;166:322–329.
    • (2001) J Immunol , vol.166 , pp. 322-329
    • Rothstein, D.M.1    Livak, M.F.2    Kishimoto, K.3
  • 114
    • 79955527672 scopus 로고    scopus 로고
    • CD40specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates
    • Thompson P, Cardona K, Russell M, et al. CD40specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. Am J Transplant. 2011;11:947–957.
    • (2011) Am J Transplant , vol.11 , pp. 947-957
    • Thompson, P.1    Cardona, K.2    Russell, M.3
  • 115
    • 84855930967 scopus 로고    scopus 로고
    • CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHCdefined rhesus macaque transplant model
    • Page A, Srinivasan S, Singh K, et al. CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHCdefined rhesus macaque transplant model. Am J Transplant. 2012;12:115–125.
    • (2012) Am J Transplant , vol.12 , pp. 115-125
    • Page, A.1    Srinivasan, S.2    Singh, K.3
  • 116
    • 19944412462 scopus 로고    scopus 로고
    • Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival
    • Adams AB, Shirasugi N, Jones TR, et al. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol. 2005;174:54250.
    • (2005) J Immunol , vol.174 , pp. 54250
    • Adams, A.B.1    Shirasugi, N.2    Jones, T.R.3
  • 117
    • 0037443913 scopus 로고    scopus 로고
    • Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates
    • Haanstra KG, Ringers J, Sick EA, et al. Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates. Transplantation. 2003;75:637–643.
    • (2003) Transplantation , vol.75 , pp. 637-643
    • Haanstra, K.G.1    Ringers, J.2    Sick, E.A.3
  • 118
    • 0037108717 scopus 로고    scopus 로고
    • Anti-CD40 therapy extends renal allograft survival in rhesus macaques
    • Pearson TC, Trambley J, Odom K, et al. Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation. 2002;74:933–940.
    • (2002) Transplantation , vol.74 , pp. 933-940
    • Pearson, T.C.1    Trambley, J.2    Odom, K.3
  • 119
    • 67650966708 scopus 로고    scopus 로고
    • A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: Induction and maintenance therapy
    • Aoyagi T, Yamashita K, Suzuki T, et al. A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: Induction and maintenance therapy. Am J Transplant. 2009;9:1732–1741.
    • (2009) Am J Transplant , vol.9 , pp. 1732-1741
    • Aoyagi, T.1    Yamashita, K.2    Suzuki, T.3
  • 120
    • 37349029002 scopus 로고    scopus 로고
    • A novel fully human antiCD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys
    • Imai A, Suzuki T, Sugitani A, et al. A novel fully human antiCD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys. Transplantation. 2007;84:1020–1028.
    • (2007) Transplantation , vol.84 , pp. 1020-1028
    • Imai, A.1    Suzuki, T.2    Sugitani, A.3
  • 121
    • 84899515806 scopus 로고    scopus 로고
    • Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases
    • Xie JH, Yamniuk AP, Borowski V, et al. Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases. J Immunol. 2014;192:4083–4092.
    • (2014) J Immunol , vol.192 , pp. 4083-4092
    • Xie, J.H.1    Yamniuk, A.P.2    Borowski, V.3
  • 122
    • 0033590502 scopus 로고    scopus 로고
    • ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    • Hutloff A, Dittrich AM, Beier KC, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999;397:263–266.
    • (1999) Nature , vol.397 , pp. 263-266
    • Hutloff, A.1    Dittrich, A.M.2    Beier, K.C.3
  • 123
    • 77952348017 scopus 로고    scopus 로고
    • Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)
    • Simpson TR, Quezada SA, Allison JP. Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). Curr Opin Immunol. 2010;22:326–332.
    • (2010) Curr Opin Immunol , vol.22 , pp. 326-332
    • Simpson, T.R.1    Quezada, S.A.2    Allison, J.P.3
  • 124
    • 0035804254 scopus 로고    scopus 로고
    • ICOS co-stimulatory receptor is essential for T-cell activation and function
    • Dong C, Juedes AE, Temann UA, et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 2001;409:97–101.
    • (2001) Nature , vol.409 , pp. 97-101
    • Dong, C.1    Juedes, A.E.2    Temann, U.A.3
  • 125
    • 0034912364 scopus 로고    scopus 로고
    • ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses
    • Gonzalo JA, Tian J, Delaney T, et al. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat Immunol. 2001;2:597–604.
    • (2001) Nat Immunol , vol.2 , pp. 597-604
    • Gonzalo, J.A.1    Tian, J.2    Delaney, T.3
  • 126
    • 0034922160 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE
    • Rottman JB, Smith T, Tonra JR, et al. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat Immunol. 2001;2:605–611.
    • (2001) Nat Immunol , vol.2 , pp. 605-611
    • Rottman, J.B.1    Smith, T.2    Tonra, J.R.3
  • 127
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol. 2009;10:167–175.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3
  • 128
    • 84876793426 scopus 로고    scopus 로고
    • Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility
    • Xu H, Li X, Liu D, et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature. 2013;496:523–527.
    • (2013) Nature , vol.496 , pp. 523-527
    • Xu, H.1    Li, X.2    Liu, D.3
  • 129
    • 0035804268 scopus 로고    scopus 로고
    • ICOS is critical for CD40-mediated antibody class switching
    • McAdam AJ, Greenwald RJ, Levin MA, et al. ICOS is critical for CD40-mediated antibody class switching. Nature. 2001;409:102–105.
    • (2001) Nature , vol.409 , pp. 102-105
    • McAdam, A.J.1    Greenwald, R.J.2    Levin, M.A.3
  • 130
    • 58049211975 scopus 로고    scopus 로고
    • Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac grafts
    • Schenk AD, Gorbacheva V, Rabant M, Fairchild RL, Valujskikh A. Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac grafts. Am J Transplant. 2009;9:64–73.
    • (2009) Am J Transplant , vol.9 , pp. 64-73
    • Schenk, A.D.1    Gorbacheva, V.2    Rabant, M.3    Fairchild, R.L.4    Valujskikh, A.5
  • 131
    • 0034917195 scopus 로고    scopus 로고
    • Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
    • Ozkaynak E, Gao W, Shemmeri N, et al. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat Immunol. 2001;2:591–596.
    • (2001) Nat Immunol , vol.2 , pp. 591-596
    • Ozkaynak, E.1    Gao, W.2    Shemmeri, N.3
  • 132
    • 33644779799 scopus 로고    scopus 로고
    • Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse
    • Nanji SA, Hancock WW, Luo B, et al. Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse. Diabetes. 2006;55:27–33.
    • (2006) Diabetes , vol.55 , pp. 27-33
    • Nanji, S.A.1    Hancock, W.W.2    Luo, B.3
  • 133
    • 11144354562 scopus 로고    scopus 로고
    • Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival
    • Nanji SA, Hancock WW, Anderson CC, et al. Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival. Am J Transplant. 2004;4:526–536.
    • (2004) Am J Transplant , vol.4 , pp. 526-536
    • Nanji, S.A.1    Hancock, W.W.2    Anderson, C.C.3
  • 134
    • 17044374080 scopus 로고    scopus 로고
    • Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM)
    • Taylor PA, Panoskaltsis-Mortari A, Freeman GJ, et al. Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood. 2005;105:3372–3380.
    • (2005) Blood , vol.105 , pp. 3372-3380
    • Taylor, P.A.1    Panoskaltsis-Mortari, A.2    Freeman, G.J.3
  • 135
    • 84879840863 scopus 로고    scopus 로고
    • Inducible costimulator (ICOS) up-regulation on activated T cells in chronic graftversus-host disease after dog leukocyte antigen-nonidentical hematopoietic cell transplantation: A potential therapeutic target
    • Sato M, Storb R, Loretz C, et al. Inducible costimulator (ICOS) up-regulation on activated T cells in chronic graftversus-host disease after dog leukocyte antigen-nonidentical hematopoietic cell transplantation: A potential therapeutic target. Transplantation. 2013;96:34–41.
    • (2013) Transplantation , vol.96 , pp. 34-41
    • Sato, M.1    Storb, R.2    Loretz, C.3
  • 136
    • 0035889922 scopus 로고    scopus 로고
    • Opposing effects of anti-activation-inducible lymphocyteimmunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease
    • Ogawa S, Nagamatsu G, Watanabe M, et al. Opposing effects of anti-activation-inducible lymphocyteimmunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease. J Immunol. 2001;167:5741–5748.
    • (2001) J Immunol , vol.167 , pp. 5741-5748
    • Ogawa, S.1    Nagamatsu, G.2    Watanabe, M.3
  • 137
    • 84902668500 scopus 로고    scopus 로고
    • Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans
    • Flynn R, Du J, Veenstra RG, et al. Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans. Blood. 2014;123:3988–3998.
    • (2014) Blood , vol.123 , pp. 3988-3998
    • Flynn, R.1    Du, J.2    Veenstra, R.G.3
  • 138
    • 84925296544 scopus 로고    scopus 로고
    • A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation
    • Lo DJ, Anderson DJ, Song M, et al. A pilot trial targeting the ICOS-ICOS-L pathway in nonhuman primate kidney transplantation. Am J Transplant. 2015;15:984–992.
    • (2015) Am J Transplant , vol.15 , pp. 984-992
    • Lo, D.J.1    Anderson, D.J.2    Song, M.3
  • 139
    • 0033427044 scopus 로고    scopus 로고
    • Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions
    • Chen AI, McAdam AJ, Buhlmann JE, et al. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity. 1999;11:68998.
    • (1999) Immunity , vol.11 , pp. 68998
    • Chen, A.I.1    McAdam, A.J.2    Buhlmann, J.E.3
  • 140
    • 0033427047 scopus 로고    scopus 로고
    • OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection
    • Kopf M, Ruedl C, Schmitz N, et al. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity. 1999;11:699–708.
    • (1999) Immunity , vol.11 , pp. 699-708
    • Kopf, M.1    Ruedl, C.2    Schmitz, N.3
  • 143
    • 0034177891 scopus 로고    scopus 로고
    • Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation
    • Tsukada N, Akiba H, Kobata T, Aizawa Y, Yagita H, Okumura K. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation. Blood. 2000;95:2434–2439.
    • (2000) Blood , vol.95 , pp. 2434-2439
    • Tsukada, N.1    Akiba, H.2    Kobata, T.3    Aizawa, Y.4    Yagita, H.5    Okumura, K.6
  • 144
    • 0037528710 scopus 로고    scopus 로고
    • Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, Sharpe AH, Chen AI, et al. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood. 2003;101:3741–3748.
    • (2003) Blood , vol.101 , pp. 3741-3748
    • Blazar, B.R.1    Sharpe, A.H.2    Chen, A.I.3
  • 145
    • 4544268251 scopus 로고    scopus 로고
    • + (OX40) T lymphocytes during acute and chronic graft-versus-host disease after allogeneic bone marrow transplantation
    • + (OX40) T lymphocytes during acute and chronic graft-versus-host disease after allogeneic bone marrow transplantation. Br J Haematol. 2004;126:697–703.
    • (2004) Br J Haematol , vol.126 , pp. 697-703
    • Sanchez, J.1    Casano, J.2    Alvarez, M.A.3
  • 147
    • 55449090373 scopus 로고    scopus 로고
    • The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease
    • Moncrieffe H, Coles M, Stockinger B. The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease. Immunology. 2008;125:459–468.
    • (2008) Immunology , vol.125 , pp. 459-468
    • Moncrieffe, H.1    Coles, M.2    Stockinger, B.3
  • 148
    • 41849135800 scopus 로고    scopus 로고
    • CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemiaspecific effectors
    • Ge X, Brown J, Sykes M, Boussiotis VA. CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemiaspecific effectors. Biol Blood Marrow Transplant. 2008;14:518–530.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 518-530
    • Ge, X.1    Brown, J.2    Sykes, M.3    Boussiotis, V.A.4
  • 149
    • 1642485023 scopus 로고    scopus 로고
    • Critical role of OX40 in CD28 and CD154-independent rejection
    • Demirci G, Amanullah F, Kewalaramani R, et al. Critical role of OX40 in CD28 and CD154-independent rejection. J Immunol. 2004;172:1691–1698.
    • (2004) J Immunol , vol.172 , pp. 1691-1698
    • Demirci, G.1    Amanullah, F.2    Kewalaramani, R.3
  • 151
    • 84921487573 scopus 로고    scopus 로고
    • Designing chimeric antigen receptors to effectively and safely target tumors
    • Jensen MC, Riddell SR. Designing chimeric antigen receptors to effectively and safely target tumors. Curr Opin Immunol. 2015;33:9–15.
    • (2015) Curr Opin Immunol , vol.33 , pp. 9-15
    • Jensen, M.C.1    Riddell, S.R.2
  • 152
    • 84979988130 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for B cell neoplasms: Choose the right CAR for you
    • Ruella M, June CH. Chimeric antigen receptor T cells for B cell neoplasms: Choose the right CAR for you. Curr Hematol Malig Rep. 2016;11:368–384.
    • (2016) Curr Hematol Malig Rep , vol.11 , pp. 368-384
    • Ruella, M.1    June, C.H.2
  • 154
    • 0028009709 scopus 로고
    • 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells
    • Pollok KE, Kim YJ, Hurtado J, Zhou Z, Kim KK, Kwon BS. 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. Eur J Immunol. 1994;24:367–374.
    • (1994) Eur J Immunol , vol.24 , pp. 367-374
    • Pollok, K.E.1    Kim, Y.J.2    Hurtado, J.3    Zhou, Z.4    Kim, K.K.5    Kwon, B.S.6
  • 155
    • 0027285735 scopus 로고
    • Inducible T cell antigen 4-1BB. Analysis of expression and function
    • Pollok KE, Kim YJ, Zhou Z, et al. Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol. 1993;150:771–781.
    • (1993) J Immunol , vol.150 , pp. 771-781
    • Pollok, K.E.1    Kim, Y.J.2    Zhou, Z.3
  • 156
    • 1642314780 scopus 로고    scopus 로고
    • Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo
    • Dawicki W, Watts TH. Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo. Eur J Immunol. 2004;34:743–751.
    • (2004) Eur J Immunol , vol.34 , pp. 743-751
    • Dawicki, W.1    Watts, T.H.2
  • 157
    • 18944375012 scopus 로고    scopus 로고
    • Enhanced CD4 T cell responsiveness in the absence of 4-1BB
    • Lee SW, Vella AT, Kwon BS, Croft M. Enhanced CD4 T cell responsiveness in the absence of 4-1BB. J Immunol. 2005;174:6803–6808.
    • (2005) J Immunol , vol.174 , pp. 6803-6808
    • Lee, S.W.1    Vella, A.T.2    Kwon, B.S.3    Croft, M.4
  • 158
    • 0030845586 scopus 로고    scopus 로고
    • + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med. 1997;186:47–55.
    • (1997) J Exp Med , vol.186 , pp. 47-55
    • Shuford, W.W.1    Klussman, K.2    Tritchler, D.D.3
  • 159
    • 0035284861 scopus 로고    scopus 로고
    • Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, Kwon BS, Panoskaltsis-Mortari A, Kwak KB, Peschon JJ, Taylor PA. Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipients. J Immunol. 2001;166:3174–3183.
    • (2001) J Immunol , vol.166 , pp. 3174-3183
    • Blazar, B.R.1    Kwon, B.S.2    Panoskaltsis-Mortari, A.3    Kwak, K.B.4    Peschon, J.J.5    Taylor, P.A.6
  • 160
    • 0034327197 scopus 로고    scopus 로고
    • Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions
    • Blazar BR, Lees CJ, Martin PJ, et al. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol. 2000;165:4901–4909.
    • (2000) J Immunol , vol.165 , pp. 4901-4909
    • Blazar, B.R.1    Lees, C.J.2    Martin, P.J.3
  • 161
    • 9444292844 scopus 로고    scopus 로고
    • Functional assessment and specific depletion of alloreactive human T cells using flow cytometry
    • Martins SL, St John LS, Champlin RE, et al. Functional assessment and specific depletion of alloreactive human T cells using flow cytometry. Blood. 2004;104:3429–3436.
    • (2004) Blood , vol.104 , pp. 3429-3436
    • Martins, S.L.1    St John, L.S.2    Champlin, R.E.3
  • 163
    • 0032754036 scopus 로고    scopus 로고
    • Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
    • DeBenedette MA, Wen T, Bachmann MF, et al. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol. 1999;163:4833–4841.
    • (1999) J Immunol , vol.163 , pp. 4833-4841
    • DeBenedette, M.A.1    Wen, T.2    Bachmann, M.F.3
  • 164
    • 34249292281 scopus 로고    scopus 로고
    • Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice
    • Asai T, Choi BK, Kwon PM, et al. Blockade of the 4-1BB (CD137)/4-1BBL and/or CD28/CD80/CD86 costimulatory pathways promotes corneal allograft survival in mice. Immunology. 2007;121:349–358.
    • (2007) Immunology , vol.121 , pp. 349-358
    • Asai, T.1    Choi, B.K.2    Kwon, P.M.3
  • 166
    • 43249105058 scopus 로고    scopus 로고
    • Blockade of the 4-1BB pathway attenuates graft arterial disease in cardiac allografts
    • Saiki H, Suzuki J, Kosuge H, et al. Blockade of the 4-1BB pathway attenuates graft arterial disease in cardiac allografts. Int Heart J. 2008;49:105–118.
    • (2008) Int Heart J , vol.49 , pp. 105-118
    • Saiki, H.1    Suzuki, J.2    Kosuge, H.3
  • 167
    • 4544354937 scopus 로고    scopus 로고
    • Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival
    • Cho HR, Kwon B, Yagita H, et al. Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int. 2004;17:351–361.
    • (2004) Transpl Int , vol.17 , pp. 351-361
    • Cho, H.R.1    Kwon, B.2    Yagita, H.3
  • 168
    • 84890541041 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy in multiple sclerosis
    • Chalkley JJ, Berger JR. Progressive multifocal leukoencephalopathy in multiple sclerosis. Curr Neurol Neurosci Rep. 2013;13:408.
    • (2013) Curr Neurol Neurosci Rep , vol.13 , pp. 408
    • Chalkley, J.J.1    Berger, J.R.2
  • 169
    • 84890928365 scopus 로고    scopus 로고
    • Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel disease
    • Bamias G, Clark DJ, Rivera-Nieves J. Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel disease. Curr Drug Targets. 2013;14:1490–1500.
    • (2013) Curr Drug Targets , vol.14 , pp. 1490-1500
    • Bamias, G.1    Clark, D.J.2    Rivera-Nieves, J.3
  • 170
    • 29644438538 scopus 로고    scopus 로고
    • An overview of the pharmacokinetics and pharmacodynamics of efalizumab: A monoclonal antibody approved for use in psoriasis
    • Joshi A, Bauer R, Kuebler P, et al. An overview of the pharmacokinetics and pharmacodynamics of efalizumab: A monoclonal antibody approved for use in psoriasis. J Clin Pharmacol. 2006;46:10–20.
    • (2006) J Clin Pharmacol , vol.46 , pp. 10-20
    • Joshi, A.1    Bauer, R.2    Kuebler, P.3
  • 171
    • 84923141433 scopus 로고    scopus 로고
    • Sorting out the risks in progressive multifocal leukoencephalopathy
    • Calabrese LH, Molloy E, Berger J. Sorting out the risks in progressive multifocal leukoencephalopathy. Nat Rev Rheumatol. 2015;11:119–123.
    • (2015) Nat Rev Rheumatol , vol.11 , pp. 119-123
    • Calabrese, L.H.1    Molloy, E.2    Berger, J.3
  • 172
    • 80051791145 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients
    • Kothary N, Diak IL, Brinker A, Bezabeh S, Avigan M, Dal Pan G. Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients. J Am Acad Dermatol. 2011;65:546–551.
    • (2011) J Am Acad Dermatol , vol.65 , pp. 546-551
    • Kothary, N.1    Diak, I.L.2    Brinker, A.3    Bezabeh, S.4    Avigan, M.5    Dal Pan, G.6
  • 173
    • 67651158993 scopus 로고    scopus 로고
    • Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: A Review from the Research on Adverse Drug Events and Reports (RADAR) Project
    • Carson KR, Focosi D, Major EO, et al. Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: A Review from the Research on Adverse Drug Events and Reports (RADAR) Project. Lancet Oncol. 2009;10:816–824.
    • (2009) Lancet Oncol , vol.10 , pp. 816-824
    • Carson, K.R.1    Focosi, D.2    Major, E.O.3
  • 174
    • 0025802034 scopus 로고
    • Anti-LFA1 monoclonal antibody (25.3) for treatment of steroid-resistant grade III-IV acute graft-versus-host disease
    • Stoppa AM, Maraninchi D, Blaise D, et al. Anti-LFA1 monoclonal antibody (25.3) for treatment of steroid-resistant grade III-IV acute graft-versus-host disease. Transpl Int. 1991;4:3–7.
    • (1991) Transpl Int , vol.4 , pp. 3-7
    • Stoppa, A.M.1    Maraninchi, D.2    Blaise, D.3
  • 175
    • 0025916337 scopus 로고
    • Effect of anti-LFA1 (CD11a) monoclonal antibodies in acute rejection in human kidney transplantation
    • Le Mauff B, Hourmant M, Rougier JP, et al. Effect of anti-LFA1 (CD11a) monoclonal antibodies in acute rejection in human kidney transplantation. Transplantation. 1991;52:291–296.
    • (1991) Transplantation , vol.52 , pp. 291-296
    • Le Mauff, B.1    Hourmant, M.2    Rougier, J.P.3
  • 176
    • 0025840398 scopus 로고
    • Prevention of murine graft-versus-host disease and bone marrow alloengraftment across the major histocompatibility barrier after donor graft preincubation with anti-LFA1 immunotoxin
    • Blazar BR, Carroll SF, Vallera DA. Prevention of murine graft-versus-host disease and bone marrow alloengraftment across the major histocompatibility barrier after donor graft preincubation with anti-LFA1 immunotoxin. Blood. 1991;78:3093102.
    • (1991) Blood , vol.78 , pp. 3093102
    • Blazar, B.R.1    Carroll, S.F.2    Vallera, D.A.3
  • 177
    • 0028917482 scopus 로고
    • Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts
    • Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Gray GS, Vallera DA. Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts. Blood. 1995;85:2607–2618.
    • (1995) Blood , vol.85 , pp. 2607-2618
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Gray, G.S.4    Vallera, D.A.5
  • 178
    • 67650227479 scopus 로고    scopus 로고
    • Pig embryonic pancreatic tissue as a source for transplantation in diabetes: Transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression
    • Tchorsh-Yutsis D, Hecht G, Aronovich A, et al. Pig embryonic pancreatic tissue as a source for transplantation in diabetes: Transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression. Diabetes. 2009;58:1585–1594.
    • (2009) Diabetes , vol.58 , pp. 1585-1594
    • Tchorsh-Yutsis, D.1    Hecht, G.2    Aronovich, A.3
  • 179
    • 84946581113 scopus 로고    scopus 로고
    • Impact of leukocyte function-associated antigen-1 blockade on endogenous allospecific T cells to multiple minor histocompatibility antigen mismatched cardiac allograft
    • Kwun J, Farris AB, Song H, Mahle WT, Burlingham WJ, Knechtle SJ. Impact of leukocyte function-associated antigen-1 blockade on endogenous allospecific T cells to multiple minor histocompatibility antigen mismatched cardiac allograft. Transplantation. 2015;99:2485–2493.
    • (2015) Transplantation , vol.99 , pp. 2485-2493
    • Kwun, J.1    Farris, A.B.2    Song, H.3    Mahle, W.T.4    Burlingham, W.J.5    Knechtle, S.J.6
  • 180
    • 84872600153 scopus 로고    scopus 로고
    • Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients
    • Ramsey H, Pilat N, Hock K, et al. Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients. Transpl Int. 2013;26:206–218.
    • (2013) Transpl Int , vol.26 , pp. 206-218
    • Ramsey, H.1    Pilat, N.2    Hock, K.3
  • 181
    • 84861093557 scopus 로고    scopus 로고
    • Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses
    • Kitchens WH, Haridas D, Wagener ME, Song M, Ford ML. Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses. Transplantation. 2012;93:997–1005.
    • (2012) Transplantation , vol.93 , pp. 997-1005
    • Kitchens, W.H.1    Haridas, D.2    Wagener, M.E.3    Song, M.4    Ford, M.L.5
  • 182
    • 82155178641 scopus 로고    scopus 로고
    • LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function
    • Reisman NM, Floyd TL, Wagener ME, Kirk AD, Larsen CP, Ford ML. LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function. Blood. 2011;118:5851–5861.
    • (2011) Blood , vol.118 , pp. 5851-5861
    • Reisman, N.M.1    Floyd, T.L.2    Wagener, M.E.3    Kirk, A.D.4    Larsen, C.P.5    Ford, M.L.6
  • 183
    • 79955544000 scopus 로고    scopus 로고
    • LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming
    • Setoguchi K, Schenk AD, Ishii D, et al. LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming. Am J Transplant. 2011;11:923–935.
    • (2011) Am J Transplant , vol.11 , pp. 923-935
    • Setoguchi, K.1    Schenk, A.D.2    Ishii, D.3
  • 184
    • 79952668647 scopus 로고    scopus 로고
    • Integrin antagonists for transplant immunosuppression: Panacea or peril?
    • Kitchens WH, Larsen CP, Ford ML. Integrin antagonists for transplant immunosuppression: Panacea or peril? Immunotherapy. 2011;3:305–307.
    • (2011) Immunotherapy , vol.3 , pp. 305-307
    • Kitchens, W.H.1    Larsen, C.P.2    Ford, M.L.3
  • 185
    • 78649835002 scopus 로고    scopus 로고
    • LFA-1-specific therapy prolongs allograft survival in rhesus macaques
    • Badell IR, Russell MC, Thompson PW, et al. LFA-1-specific therapy prolongs allograft survival in rhesus macaques. J Clin Invest. 2010;120:4520–4531.
    • (2010) J Clin Invest , vol.120 , pp. 4520-4531
    • Badell, I.R.1    Russell, M.C.2    Thompson, P.W.3
  • 186
    • 77954892240 scopus 로고    scopus 로고
    • Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab
    • Posselt AM, Bellin MD, Tavakol M, et al. Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab. Am J Transplant. 2010;10:187080.
    • (2010) Am J Transplant , vol.10 , pp. 187080
    • Posselt, A.M.1    Bellin, M.D.2    Tavakol, M.3
  • 187
    • 70350571793 scopus 로고    scopus 로고
    • Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation
    • Wang Y, Li D, Jones D, et al. Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation. Biol Blood Marrow Transplant. 2009;15:1513–1522.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 1513-1522
    • Wang, Y.1    Li, D.2    Jones, D.3
  • 188
    • 34250202520 scopus 로고    scopus 로고
    • A phase I/II randomized openlabel multicenter trial of efalizumab, a humanized anti-CD11a, anti-LFA-1 in renal transplantation
    • Vincenti F, Mendez R, Pescovitz M, et al. A phase I/II randomized openlabel multicenter trial of efalizumab, a humanized anti-CD11a, anti-LFA-1 in renal transplantation. Am J Transplant. 2007;7:1770–1777.
    • (2007) Am J Transplant , vol.7 , pp. 1770-1777
    • Vincenti, F.1    Mendez, R.2    Pescovitz, M.3
  • 189
    • 84881136896 scopus 로고    scopus 로고
    • Heterologous immunity triggered by a single, latent virus in Mus musculus: Combined costimulation- and adhesion- blockade decrease rejection
    • Beus JM, Hashmi SS, Selvaraj SA, et al. Heterologous immunity triggered by a single, latent virus in Mus musculus: Combined costimulation- and adhesion- blockade decrease rejection. PLoS ONE. 2013;8:e71221.
    • (2013) PLoS ONE , vol.8
    • Beus, J.M.1    Hashmi, S.S.2    Selvaraj, S.A.3
  • 190
    • 84954432589 scopus 로고    scopus 로고
    • Anti-leukocyte function-associated antigen therapy in a nonhuman primate renal transplant model of costimulation blockaderesistant rejection
    • Anderson DJ, Lo DJ, Leopardi F, et al. Anti-leukocyte function-associated antigen therapy in a nonhuman primate renal transplant model of costimulation blockaderesistant rejection. Am J Transplant. 2016;16:1456–1464.
    • (2016) Am J Transplant , vol.16 , pp. 1456-1464
    • Anderson, D.J.1    Lo, D.J.2    Leopardi, F.3
  • 191
    • 84855943600 scopus 로고    scopus 로고
    • Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells
    • Kitchens WH, Haridas D, Wagener ME, et al. Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells. Am J Transplant. 2012;12:69–80.
    • (2012) Am J Transplant , vol.12 , pp. 69-80
    • Kitchens, W.H.1    Haridas, D.2    Wagener, M.E.3
  • 192
    • 77956145092 scopus 로고    scopus 로고
    • Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation
    • Turgeon NA, Avila JG, Cano JA, et al. Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation. Am J Transplant. 2010;10:2082–2091.
    • (2010) Am J Transplant , vol.10 , pp. 2082-2091
    • Turgeon, N.A.1    Avila, J.G.2    Cano, J.A.3
  • 193
    • 0027246305 scopus 로고
    • The efficacy of LFA-1 and VLA-4 antibody treatment in rat vascularized cardiac allograft rejection
    • Paul LC, Davidoff A, Benediktsson H, Issekutz TB. The efficacy of LFA-1 and VLA-4 antibody treatment in rat vascularized cardiac allograft rejection. Transplantation. 1993;55:1196–1199.
    • (1993) Transplantation , vol.55 , pp. 1196-1199
    • Paul, L.C.1    Davidoff, A.2    Benediktsson, H.3    Issekutz, T.B.4
  • 194
    • 0029149664 scopus 로고
    • Prolongation of islet allograft survival with an antibody to vascular cell adhesion molecule 1
    • discussion 9–70
    • Stegall MD, Ostrowska A, Haynes J, Karrer F, Kam I, Gill RG. Prolongation of islet allograft survival with an antibody to vascular cell adhesion molecule 1. Surgery. 1995;118:366–369; discussion 9–70.
    • (1995) Surgery , vol.118 , pp. 366-369
    • Stegall, M.D.1    Ostrowska, A.2    Haynes, J.3    Karrer, F.4    Kam, I.5    Gill, R.G.6
  • 195
    • 0029079296 scopus 로고
    • Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts
    • Molossi S, Elices M, Arrhenius T, Diaz R, Coulber C, Rabinovitch M. Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts. J Clin Invest. 1995;95:2601–2610.
    • (1995) J Clin Invest , vol.95 , pp. 2601-2610
    • Molossi, S.1    Elices, M.2    Arrhenius, T.3    Diaz, R.4    Coulber, C.5    Rabinovitch, M.6
  • 196
    • 0029014088 scopus 로고
    • Prolongation of rat islet allograft survival by treatment with monoclonal antibodies against VLA-4 and LFA-1
    • Yang H, Issekutz TB, Wright JR Jr. Prolongation of rat islet allograft survival by treatment with monoclonal antibodies against VLA-4 and LFA-1. Transplantation. 1995;60:71–76.
    • (1995) Transplantation , vol.60 , pp. 71-76
    • Yang, H.1    Issekutz, T.B.2    Wright, J.R.3
  • 197
    • 0023753444 scopus 로고
    • Locally administered monoclonal antibodies to lymphocyte function-associated antigen 1 and to L3T4 prevent cutaneous graft-vs-host disease
    • Shiohara T, Moriya N, Gotoh C, Saizawa K, Nagashima M. Locally administered monoclonal antibodies to lymphocyte function-associated antigen 1 and to L3T4 prevent cutaneous graft-vs-host disease. J Immunol. 1988;141:2261–2267.
    • (1988) J Immunol , vol.141 , pp. 2261-2267
    • Shiohara, T.1    Moriya, N.2    Gotoh, C.3    Saizawa, K.4    Nagashima, M.5
  • 198
    • 0025841706 scopus 로고
    • Reduction in the severity of graft-versus-host disease and increased survival in allogenic mice by treatment with monoclonal antibodies to cell adhesion antigens LFA-1 alpha and MALA-2
    • Harning R, Pelletier J, Lubbe K, Takei F, Merluzzi VJ. Reduction in the severity of graft-versus-host disease and increased survival in allogenic mice by treatment with monoclonal antibodies to cell adhesion antigens LFA-1 alpha and MALA-2. Transplantation. 1991;52:842–845.
    • (1991) Transplantation , vol.52 , pp. 842-845
    • Harning, R.1    Pelletier, J.2    Lubbe, K.3    Takei, F.4    Merluzzi, V.J.5
  • 199
    • 0029162797 scopus 로고
    • Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers
    • Schlegel PG, Vaysburd M, Chen Y, Butcher EC, Chao NJ. Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. J Immunol. 1995;155:3856–3865.
    • (1995) J Immunol , vol.155 , pp. 3856-3865
    • Schlegel, P.G.1    Vaysburd, M.2    Chen, Y.3    Butcher, E.C.4    Chao, N.J.5
  • 200
    • 84959900783 scopus 로고    scopus 로고
    • Fingolimod in the treatment of relapsing-remitting multiple sclerosis: Long-term experience and an update on the clinical evidence
    • Khatri BO. Fingolimod in the treatment of relapsing-remitting multiple sclerosis: Long-term experience and an update on the clinical evidence. Ther Adv Neurol Disord. 2016;9:130–147.
    • (2016) Ther Adv Neurol Disord , vol.9 , pp. 130-147
    • Khatri, B.O.1
  • 201
    • 84951864477 scopus 로고    scopus 로고
    • Optimizing treatment success in multiple sclerosis
    • Ziemssen T, Derfuss T, de Stefano N, et al. Optimizing treatment success in multiple sclerosis. J Neurol. 2016;263:1053–1065.
    • (2016) J Neurol , vol.263 , pp. 1053-1065
    • Ziemssen, T.1    Derfuss, T.2    de Stefano, N.3
  • 202
    • 0033668231 scopus 로고    scopus 로고
    • Effect of a novel immunosuppressant, FTY720, on allograft survival after renal transplant in rats
    • Ueda H, Takahara S, Azuma H, Kusaka M, Suzuki S, Katsuoka Y. Effect of a novel immunosuppressant, FTY720, on allograft survival after renal transplant in rats. Eur Surg Res. 2000;32:279–283.
    • (2000) Eur Surg Res , vol.32 , pp. 279-283
    • Ueda, H.1    Takahara, S.2    Azuma, H.3    Kusaka, M.4    Suzuki, S.5    Katsuoka, Y.6
  • 203
    • 80155171844 scopus 로고    scopus 로고
    • Group FTYPITS. FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study
    • Hoitsma AJ, Woodle ES, Abramowicz D, Proot P, Vanrenterghem Y. Group FTYPITS. FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study. Nephrol Dial Transplant. 2011;26:3802–3805.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 3802-3805
    • Hoitsma, A.J.1    Woodle, E.S.2    Abramowicz, D.3    Proot, P.4    Vanrenterghem, Y.5
  • 204
    • 84878580539 scopus 로고    scopus 로고
    • FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin
    • Huu DL, Matsushita T, Jin G, et al. FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin. Arthritis Rheum. 2013;65:1624–1635.
    • (2013) Arthritis Rheum , vol.65 , pp. 1624-1635
    • Huu, D.L.1    Matsushita, T.2    Jin, G.3
  • 205
    • 84865159873 scopus 로고    scopus 로고
    • FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal
    • Taylor PA, Kelly RM, Bade ND, Smith MJ, Stefanski HE, Blazar BR. FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal. Biol Blood Marrow Transplant. 2012;18:134152.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 134152
    • Taylor, P.A.1    Kelly, R.M.2    Bade, N.D.3    Smith, M.J.4    Stefanski, H.E.5    Blazar, B.R.6
  • 206
    • 77950681760 scopus 로고    scopus 로고
    • Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720
    • Weckbecker G, Pally C, Beerli C, et al. Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720. Transpl Int. 2010;23:543–552.
    • (2010) Transpl Int , vol.23 , pp. 543-552
    • Weckbecker, G.1    Pally, C.2    Beerli, C.3
  • 207
    • 42949096167 scopus 로고    scopus 로고
    • Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice
    • Lopes CT, Gallo AP, Palma PV, Cury PM, Bueno V. Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice. Transplant Proc. 2008;40:856–860.
    • (2008) Transplant Proc , vol.40 , pp. 856-860
    • Lopes, C.T.1    Gallo, A.P.2    Palma, P.V.3    Cury, P.M.4    Bueno, V.5
  • 208
    • 36148983810 scopus 로고    scopus 로고
    • Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)
    • Taylor PA, Ehrhardt MJ, Lees CJ, et al. Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD). Blood. 2007;110:3480–3488.
    • (2007) Blood , vol.110 , pp. 3480-3488
    • Taylor, P.A.1    Ehrhardt, M.J.2    Lees, C.J.3
  • 209
    • 0030049234 scopus 로고    scopus 로고
    • A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation
    • Suzuki S, Enosawa S, Kakefuda T, et al. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation. 1996;61:200–205.
    • (1996) Transplantation , vol.61 , pp. 200-205
    • Suzuki, S.1    Enosawa, S.2    Kakefuda, T.3
  • 210
    • 0032103938 scopus 로고    scopus 로고
    • FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo
    • Yanagawa Y, Sugahara K, Kataoka H, Kawaguchi T, Masubuchi Y, Chiba K. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J Immunol. 1998;160:5493–5499.
    • (1998) J Immunol , vol.160 , pp. 5493-5499
    • Yanagawa, Y.1    Sugahara, K.2    Kataoka, H.3    Kawaguchi, T.4    Masubuchi, Y.5    Chiba, K.6
  • 211
    • 0032525049 scopus 로고    scopus 로고
    • FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing
    • Chiba K, Yanagawa Y, Masubuchi Y, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol. 1998;160:5037–5044.
    • (1998) J Immunol , vol.160 , pp. 5037-5044
    • Chiba, K.1    Yanagawa, Y.2    Masubuchi, Y.3
  • 212
    • 33846368457 scopus 로고    scopus 로고
    • FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease
    • Hashimoto D, Asakura S, Matsuoka K, et al. FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease. Eur J Immunol. 2007;37:271–281.
    • (2007) Eur J Immunol , vol.37 , pp. 271-281
    • Hashimoto, D.1    Asakura, S.2    Matsuoka, K.3
  • 213
    • 0242363653 scopus 로고    scopus 로고
    • FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigennonidentical unrelated canine model
    • Lee RS, Kuhr CS, Sale GE, et al. FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigennonidentical unrelated canine model. Transplantation. 2003;76:1155–1158.
    • (2003) Transplantation , vol.76 , pp. 1155-1158
    • Lee, R.S.1    Kuhr, C.S.2    Sale, G.E.3
  • 214
    • 0037373487 scopus 로고    scopus 로고
    • Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720
    • Kim YM, Sachs T, Asavaroengchai W, Bronson R, Sykes M. Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. J Clin Invest. 2003;111:659–669.
    • (2003) J Clin Invest , vol.111 , pp. 659-669
    • Kim, Y.M.1    Sachs, T.2    Asavaroengchai, W.3    Bronson, R.4    Sykes, M.5
  • 215
    • 0038576227 scopus 로고    scopus 로고
    • The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade
    • Blaha P, Bigenzahn S, Koporc Z, et al. The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood. 2003;101:2886–2893.
    • (2003) Blood , vol.101 , pp. 2886-2893
    • Blaha, P.1    Bigenzahn, S.2    Koporc, Z.3
  • 216
    • 0037180926 scopus 로고    scopus 로고
    • What role for FTY720, a novel immunosuppressive agent, in canine nonmyeloablative hematopoietic stem cell transplantation?
    • Xun CQ, Little MT, Zellmer E, et al. What role for FTY720, a novel immunosuppressive agent, in canine nonmyeloablative hematopoietic stem cell transplantation? Transplantation. 2002;73:310–313.
    • (2002) Transplantation , vol.73 , pp. 310-313
    • Xun, C.Q.1    Little, M.T.2    Zellmer, E.3
  • 217
    • 0037320462 scopus 로고    scopus 로고
    • Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction
    • Murai M, Yoneyama H, Ezaki T, et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol. 2003;4:15460.
    • (2003) Nat Immunol , vol.4 , pp. 15460
    • Murai, M.1    Yoneyama, H.2    Ezaki, T.3
  • 218
    • 0032740991 scopus 로고    scopus 로고
    • Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease
    • Murai M, Yoneyama H, Harada A, et al. Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J Clin Invest. 1999;104:49–57.
    • (1999) J Clin Invest , vol.104 , pp. 49-57
    • Murai, M.1    Yoneyama, H.2    Harada, A.3
  • 219
    • 3142661927 scopus 로고    scopus 로고
    • Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning
    • Wysocki CA, Burkett SB, Panoskaltsis-Mortari A, et al. Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning. J Immunol. 2004;173:845–854.
    • (2004) J Immunol , vol.173 , pp. 845-854
    • Wysocki, C.A.1    Burkett, S.B.2    Panoskaltsis-Mortari, A.3
  • 220
    • 1542357313 scopus 로고    scopus 로고
    • An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease
    • Welniak LA, Wang Z, Sun K, et al. An absence of CCR5 on donor cells results in acceleration of acute graft-vs-host disease. Exp Hematol. 2004;32:318–324.
    • (2004) Exp Hematol , vol.32 , pp. 318-324
    • Welniak, L.A.1    Wang, Z.2    Sun, K.3
  • 221
    • 84863680262 scopus 로고    scopus 로고
    • Blockade of lymphocyte chemotaxis in visceral graftversus-host disease
    • Reshef R, Luger SM, Hexner EO, et al. Blockade of lymphocyte chemotaxis in visceral graftversus-host disease. N Engl J Med. 2012;367:135–145.
    • (2012) N Engl J Med , vol.367 , pp. 135-145
    • Reshef, R.1    Luger, S.M.2    Hexner, E.O.3
  • 222
    • 0026657206 scopus 로고
    • Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies
    • Chavin KD, Lau HT, Bromberg JS. Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies. Transplantation. 1992;54:286–291.
    • (1992) Transplantation , vol.54 , pp. 286-291
    • Chavin, K.D.1    Lau, H.T.2    Bromberg, J.S.3
  • 224
    • 67650506103 scopus 로고    scopus 로고
    • Alefacept promotes costimulation blockade based allograft survival in nonhuman primates
    • Weaver TA, Charafeddine AH, Agarwal A, et al. Alefacept promotes costimulation blockade based allograft survival in nonhuman primates. Nat Med. 2009;15:746–749.
    • (2009) Nat Med , vol.15 , pp. 746-749
    • Weaver, T.A.1    Charafeddine, A.H.2    Agarwal, A.3
  • 225
    • 84941314760 scopus 로고    scopus 로고
    • Use of alefacept for preconditioning in multiply transfused pediatric patients with nonmalignant diseases
    • Stenger EO, Chiang KY, Haight A, Qayed M, Kean L, Horan J. Use of alefacept for preconditioning in multiply transfused pediatric patients with nonmalignant diseases. Biol Blood Marrow Transplant. 2015;21:1845–1852.
    • (2015) Biol Blood Marrow Transplant , vol.21 , pp. 1845-1852
    • Stenger, E.O.1    Chiang, K.Y.2    Haight, A.3    Qayed, M.4    Kean, L.5    Horan, J.6
  • 226
    • 84939218518 scopus 로고    scopus 로고
    • Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients
    • Rigby MR, Harris KM, Pinckney A, et al. Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest. 2015;125:3285–3296.
    • (2015) J Clin Invest , vol.125 , pp. 3285-3296
    • Rigby, M.R.1    Harris, K.M.2    Pinckney, A.3
  • 227
    • 84887621720 scopus 로고    scopus 로고
    • Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial
    • Rigby MR, DiMeglio LA, Rendell MS, et al. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 2013;1:284–294.
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 284-294
    • Rigby, M.R.1    DiMeglio, L.A.2    Rendell, M.S.3
  • 228
    • 84861568296 scopus 로고    scopus 로고
    • Regulatory immune cells in transplantation
    • Wood KJ, Bushell A, Hester J. Regulatory immune cells in transplantation. Nat Rev Immunol. 2012;12:417–430.
    • (2012) Nat Rev Immunol , vol.12 , pp. 417-430
    • Wood, K.J.1    Bushell, A.2    Hester, J.3
  • 229
    • 84987819121 scopus 로고    scopus 로고
    • Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma
    • Daud AI, Loo K, Pauli ML, et al. Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest. 2016;126:3447–3452.
    • (2016) J Clin Invest , vol.126 , pp. 3447-3452
    • Daud, A.I.1    Loo, K.2    Pauli, M.L.3
  • 230
    • 84922917657 scopus 로고    scopus 로고
    • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
    • Huynh A, DuPage M, Priyadharshini B, et al. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol. 2015;16:188–196.
    • (2015) Nat Immunol , vol.16 , pp. 188-196
    • Huynh, A.1    DuPage, M.2    Priyadharshini, B.3
  • 231
    • 9444280125 scopus 로고    scopus 로고
    • + Tregulatory cells are potent inhibitors of GVHD and BM graft rejection
    • + Tregulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood. 2004;104:3804–3812.
    • (2004) Blood , vol.104 , pp. 3804-3812
    • Taylor, P.A.1    Panoskaltsis-Mortari, A.2    Swedin, J.M.3
  • 232
    • 33646703806 scopus 로고    scopus 로고
    • Overcoming T cell-mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and rapamycin
    • Steiner D, Brunicki N, Bachar-Lustig E, Taylor PA, Blazar BR, Reisner Y. Overcoming T cell-mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and rapamycin. Exp Hematol. 2006;34:802–808.
    • (2006) Exp Hematol , vol.34 , pp. 802-808
    • Steiner, D.1    Brunicki, N.2    Bachar-Lustig, E.3    Taylor, P.A.4    Blazar, B.R.5    Reisner, Y.6
  • 234
    • 84960337895 scopus 로고    scopus 로고
    • Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect
    • Brunstein CG, Miller JS, McKenna DH, et al. Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect. Blood. 2016;127:104451.
    • (2016) Blood , vol.127 , pp. 104451
    • Brunstein, C.G.1    Miller, J.S.2    McKenna, D.H.3
  • 235
    • 82755197890 scopus 로고    scopus 로고
    • Clinical perspectives for regulatory T cells in transplantation tolerance
    • Hippen KL, Riley JL, June CH, Blazar BR. Clinical perspectives for regulatory T cells in transplantation tolerance. Semin Immunol. 2011;23:462–468.
    • (2011) Semin Immunol , vol.23 , pp. 462-468
    • Hippen, K.L.1    Riley, J.L.2    June, C.H.3    Blazar, B.R.4
  • 236
    • 79956258982 scopus 로고    scopus 로고
    • Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    • Hippen KL, Merkel SC, Schirm DK, et al. Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med. 2011;3:83ra41.
    • (2011) Sci Transl Med , vol.3 , pp. 83ra41
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 237
    • 79251589897 scopus 로고    scopus 로고
    • Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
    • Golovina TN, Mikheeva T, Brusko TM, Blazar BR, Bluestone JA, Riley JL. Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS ONE. 2011;6:e15868.
    • (2011) PLoS ONE , vol.6
    • Golovina, T.N.1    Mikheeva, T.2    Brusko, T.M.3    Blazar, B.R.4    Bluestone, J.A.5    Riley, J.L.6
  • 238
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics
    • Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics. Blood. 2011;117:1061–1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 239
    • 70349438847 scopus 로고    scopus 로고
    • Engineering lymphocyte subsets: Tools, trials and tribulations
    • June CH, Blazar BR, Riley JL. Engineering lymphocyte subsets: Tools, trials and tribulations. Nat Rev Immunol. 2009;9:704–716.
    • (2009) Nat Rev Immunol , vol.9 , pp. 704-716
    • June, C.H.1    Blazar, B.R.2    Riley, J.L.3
  • 240
    • 65549127618 scopus 로고    scopus 로고
    • Human T regulatory cell therapy: Take a billion or so and call me in the morning
    • Riley JL, June CH, Blazar BR. Human T regulatory cell therapy: Take a billion or so and call me in the morning. Immunity. 2009;30:656–665.
    • (2009) Immunity , vol.30 , pp. 656-665
    • Riley, J.L.1    June, C.H.2    Blazar, B.R.3
  • 241
    • 84904899365 scopus 로고    scopus 로고
    • HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
    • Martelli MF, Di Ianni M, Ruggeri L, et al. HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse. Blood. 2014;124:638–644.
    • (2014) Blood , vol.124 , pp. 638-644
    • Martelli, M.F.1    Di Ianni, M.2    Ruggeri, L.3
  • 242
    • 84897521191 scopus 로고    scopus 로고
    • Designed” grafts for HLA-haploidentical stem cell transplantation
    • Martelli MF, Di Ianni M, Ruggeri L, et al. “Designed” grafts for HLA-haploidentical stem cell transplantation. Blood. 2014;123:967–973.
    • (2014) Blood , vol.123 , pp. 967-973
    • Martelli, M.F.1    Di Ianni, M.2    Ruggeri, L.3
  • 243
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood. 2011;117:3921–3928.
    • (2011) Blood , vol.117 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 245
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T Cells: New therapeutics for graft-versus-host disease
    • Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL. CD4(+)CD25(+) immunoregulatory T Cells: New therapeutics for graft-versus-host disease. J Exp Med. 2002;196:401–406.
    • (2002) J Exp Med , vol.196 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3    Klatzmann, D.4    Salomon, B.L.5
  • 246
    • 0141461418 scopus 로고    scopus 로고
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graftversus-host disease after bone marrow transplantation
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graftversus-host disease after bone marrow transplantation. Nat Med. 2003;9:1144–1150.
    • (2003) Nat Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 247
    • 0037025943 scopus 로고    scopus 로고
    • Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002;196:389–399.
    • (2002) J Exp Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 248
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood. 2002;99:3493–3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 249
    • 0035477990 scopus 로고    scopus 로고
    • + T cells: Costimulatory requirements and role in memory formation
    • + T cells: Costimulatory requirements and role in memory formation. J Immunol. 2001;167:3699–3707.
    • (2001) J Immunol , vol.167 , pp. 3699-3707
    • Gudmundsdottir, H.1    Turka, L.A.2
  • 250
    • 0036664218 scopus 로고    scopus 로고
    • Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice
    • Valujskikh A, Pantenburg B, Heeger PS. Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. Am J Transplant. 2002;2:501–509.
    • (2002) Am J Transplant , vol.2 , pp. 501-509
    • Valujskikh, A.1    Pantenburg, B.2    Heeger, P.S.3
  • 251
    • 0344553377 scopus 로고    scopus 로고
    • Heterologous immunity: An overlooked barrier to tolerance
    • Adams AB, Pearson TC, Larsen CP. Heterologous immunity: An overlooked barrier to tolerance. Immunol Rev. 2003;196:147–160.
    • (2003) Immunol Rev , vol.196 , pp. 147-160
    • Adams, A.B.1    Pearson, T.C.2    Larsen, C.P.3
  • 252
    • 0042532322 scopus 로고    scopus 로고
    • Heterologous immunity provides a potent barrier to transplantation tolerance
    • Adams AB, Williams MA, Jones TR, et al. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest. 2003;111:1887–1895.
    • (2003) J Clin Invest , vol.111 , pp. 1887-1895
    • Adams, A.B.1    Williams, M.A.2    Jones, T.R.3
  • 254
    • 31144460031 scopus 로고    scopus 로고
    • Critical, but conditional, role of OX40 in memory T cell-mediated rejection
    • Vu MD, Clarkson MR, Yagita H, Turka LA, Sayegh MH, Li XC. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol. 2006;176:1394–1401.
    • (2006) J Immunol , vol.176 , pp. 1394-1401
    • Vu, M.D.1    Clarkson, M.R.2    Yagita, H.3    Turka, L.A.4    Sayegh, M.H.5    Li, X.C.6
  • 255
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992;11:3887–3895.
    • (1992) EMBO J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 256
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    • Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 2001;291:319–322.
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1    Okazaki, T.2    Tanaka, Y.3
  • 257
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439:682–687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3
  • 258
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • Parry RV, Chemnitz JM, Frauwirth KA, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol. 2005;25:9543–9553.
    • (2005) Mol Cell Biol , vol.25 , pp. 9543-9553
    • Parry, R.V.1    Chemnitz, J.M.2    Frauwirth, K.A.3
  • 259
    • 35348866185 scopus 로고    scopus 로고
    • Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance
    • Wang L, Han R, Hancock WW. Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance. Eur J Immunol. 2007;37:2983–2990.
    • (2007) Eur J Immunol , vol.37 , pp. 2983-2990
    • Wang, L.1    Han, R.2    Hancock, W.W.3
  • 260
    • 21044441208 scopus 로고    scopus 로고
    • Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo
    • Ito T, Ueno T, Clarkson MR, et al. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J Immunol. 2005;174:6648–6656.
    • (2005) J Immunol , vol.174 , pp. 6648-6656
    • Ito, T.1    Ueno, T.2    Clarkson, M.R.3
  • 262
    • 0041845131 scopus 로고    scopus 로고
    • Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism
    • Blazar BR, Carreno BM, Panoskaltsis-Mortari A, et al. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol. 2003;171:1272–1277.
    • (2003) J Immunol , vol.171 , pp. 1272-1277
    • Blazar, B.R.1    Carreno, B.M.2    Panoskaltsis-Mortari, A.3
  • 263
    • 34547631576 scopus 로고    scopus 로고
    • PD-1-PD-L1 pathway is involved in suppressing alloreactivity of heart infiltrating t cells during murine gvhd across minor histocompatibility antigen barriers
    • Schilbach K, Schick J, Wehrmann M, et al. PD-1-PD-L1 pathway is involved in suppressing alloreactivity of heart infiltrating t cells during murine gvhd across minor histocompatibility antigen barriers. Transplantation. 2007;84:214–222.
    • (2007) Transplantation , vol.84 , pp. 214-222
    • Schilbach, K.1    Schick, J.2    Wehrmann, M.3
  • 265
    • 84907021169 scopus 로고    scopus 로고
    • Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease
    • Fujiwara H, Maeda Y, Kobayashi K, et al. Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease. J Immunol. 2014;193:2565–2573.
    • (2014) J Immunol , vol.193 , pp. 2565-2573
    • Fujiwara, H.1    Maeda, Y.2    Kobayashi, K.3
  • 266
    • 20144376357 scopus 로고    scopus 로고
    • Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo
    • Sandner SE, Clarkson MR, Salama AD, et al. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol. 2005;174:3408–3415.
    • (2005) J Immunol , vol.174 , pp. 3408-3415
    • Sandner, S.E.1    Clarkson, M.R.2    Salama, A.D.3
  • 267
    • 40149110241 scopus 로고    scopus 로고
    • Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy
    • Yang J, Popoola J, Khandwala S, et al. Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy. Circulation. 2008;117:660–669.
    • (2008) Circulation , vol.117 , pp. 660-669
    • Yang, J.1    Popoola, J.2    Khandwala, S.3
  • 268
    • 80051621113 scopus 로고    scopus 로고
    • The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo
    • Yang J, Riella LV, Chock S, et al. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol. 2011;187:1113–1119.
    • (2011) J Immunol , vol.187 , pp. 1113-1119
    • Yang, J.1    Riella, L.V.2    Chock, S.3
  • 269
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco LM, Salinas VH, Brown KE, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009;206:3015–3029.
    • (2009) J Exp Med , vol.206 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3
  • 270
    • 84891708632 scopus 로고    scopus 로고
    • Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
    • Saha A, Aoyama K, Taylor PA, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 2013;122:3062–3073.
    • (2013) Blood , vol.122 , pp. 3062-3073
    • Saha, A.1    Aoyama, K.2    Taylor, P.A.3
  • 271
    • 77954987288 scopus 로고    scopus 로고
    • Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice
    • Asakura S, Hashimoto D, Takashima S, et al. Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice. J Clin Invest. 2010;120:2370–2378.
    • (2010) J Clin Invest , vol.120 , pp. 2370-2378
    • Asakura, S.1    Hashimoto, D.2    Takashima, S.3
  • 272
    • 80051939651 scopus 로고    scopus 로고
    • Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): Shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant
    • Matte-Martone C, Venkatesan S, Tan HS, et al. Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): Shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant. J Immunol. 2011;187:1653–1663.
    • (2011) J Immunol , vol.187 , pp. 1653-1663
    • Matte-Martone, C.1    Venkatesan, S.2    Tan, H.S.3
  • 273
    • 84978399786 scopus 로고    scopus 로고
    • Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
    • Saha A, O'Connor RS, Thangavelu G, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642–2660.
    • (2016) J Clin Invest , vol.126 , pp. 2642-2660
    • Saha, A.1    O'Connor, R.S.2    Thangavelu, G.3
  • 274
    • 79952760899 scopus 로고    scopus 로고
    • Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients
    • Yi T, Li X, Yao S, et al. Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients. J Immunol. 2011;186:2739–2749.
    • (2011) J Immunol , vol.186 , pp. 2739-2749
    • Yi, T.1    Li, X.2    Yao, S.3
  • 275
    • 84920398319 scopus 로고    scopus 로고
    • B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease
    • Deng R, Cassady K, Li X, et al. B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease. J Immunol. 2015;194:560–574.
    • (2015) J Immunol , vol.194 , pp. 560-574
    • Deng, R.1    Cassady, K.2    Li, X.3
  • 276
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27:111–122.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 277
    • 85019333926 scopus 로고    scopus 로고
    • AntiPD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab
    • Menzies AM, Johnson DB, Ramanujam S, et al. AntiPD-1 therapy in patients with advanced melanoma and preexisting autoimmune disorders or major toxicity with ipilimumab. Ann Oncol. 2016; doi:10.1093/annonc/mdw443.
    • (2016) Ann Oncol
    • Menzies, A.M.1    Johnson, D.B.2    Ramanujam, S.3
  • 278
    • 85014366483 scopus 로고    scopus 로고
    • Sneaky side effects and ineffectiveness of an immunotherapy with ipilimumab in a case of metastatic melanoma
    • Krecke N, Zimmer A, Friesenhahn-Ochs B, Muller CS, Vogt T, Pfohler C. Sneaky side effects and ineffectiveness of an immunotherapy with ipilimumab in a case of metastatic melanoma. Dermatoendocrinol. 2016;8:e1199307.
    • (2016) Dermatoendocrinol , vol.8
    • Krecke, N.1    Zimmer, A.2    Friesenhahn-Ochs, B.3    Muller, C.S.4    Vogt, T.5    Pfohler, C.6
  • 279
    • 84997693823 scopus 로고    scopus 로고
    • Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy
    • Koelzer VH, Buser T, Willi N, et al. Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy. J Immunother Cancer. 2016;4:47.
    • (2016) J Immunother Cancer , vol.4 , pp. 47
    • Koelzer, V.H.1    Buser, T.2    Willi, N.3
  • 280
    • 84997418743 scopus 로고    scopus 로고
    • Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—An autopsy study
    • Koelzer VH, Rothschild SI, Zihler D, et al. Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—An autopsy study. J Immunother Cancer. 2016;4:13.
    • (2016) J Immunother Cancer , vol.4 , pp. 13
    • Koelzer, V.H.1    Rothschild, S.I.2    Zihler, D.3
  • 281
    • 84963860995 scopus 로고    scopus 로고
    • Clinical, endoscopic, and histologic characteristics of ipilimumab-associated colitis
    • Verschuren EC, van den Eertwegh AJ, Wonders J, et al. Clinical, endoscopic, and histologic characteristics of ipilimumab-associated colitis. Clin Gastroenterol Hepatol. 2016;14:836–842.
    • (2016) Clin Gastroenterol Hepatol , vol.14 , pp. 836-842
    • Verschuren, E.C.1    van den Eertwegh, A.J.2    Wonders, J.3
  • 282
    • 85003054266 scopus 로고    scopus 로고
    • Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders
    • Johnson DB, Sullivan RJ, Ott PA, et al. Ipilimumab therapy in patients with advanced melanoma and preexisting autoimmune disorders. JAMA Oncol. 2016;2:234–240.
    • (2016) JAMA Oncol , vol.2 , pp. 234-240
    • Johnson, D.B.1    Sullivan, R.J.2    Ott, P.A.3
  • 283
    • 84978402706 scopus 로고    scopus 로고
    • Ipilimumab for patients with relapse after allogeneic transplantation
    • Davids MS, Kim HT, Bachireddy P, et al. Leukemia and Lymphoma Society Blood Cancer Research Partnership. Ipilimumab for patients with relapse after allogeneic transplantation. N Engl J Med. 2016;375:143–153.
    • (2016) N Engl J Med , vol.375 , pp. 143-153
    • Davids, M.S.1    Kim, H.T.2    Bachireddy, P.3
  • 284
    • 84964292818 scopus 로고    scopus 로고
    • Fatal GvHD induced by PD-1 inhibitor pembrolizumab in a patient with Hodgkin's lymphoma
    • Singh AK, Porrata LF, Aljitawi O, et al. Fatal GvHD induced by PD-1 inhibitor pembrolizumab in a patient with Hodgkin's lymphoma. Bone Marrow Transplant. 2016;51:1268–1270.
    • (2016) Bone Marrow Transplant , vol.51 , pp. 1268-1270
    • Singh, A.K.1    Porrata, L.F.2    Aljitawi, O.3
  • 285
    • 84944079434 scopus 로고    scopus 로고
    • Challenges and opportunities of allogeneic donorderived CAR T cells
    • Yang Y, Jacoby E, Fry TJ. Challenges and opportunities of allogeneic donorderived CAR T cells. Curr Opin Hematol. 2015;22:509–515.
    • (2015) Curr Opin Hematol , vol.22 , pp. 509-515
    • Yang, Y.1    Jacoby, E.2    Fry, T.J.3
  • 286
    • 84890827981 scopus 로고    scopus 로고
    • Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
    • Kochenderfer JN, Dudley ME, Carpenter RO, et al. Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood. 2013;122:4129–4139.
    • (2013) Blood , vol.122 , pp. 4129-4139
    • Kochenderfer, J.N.1    Dudley, M.E.2    Carpenter, R.O.3
  • 287
    • 84960517214 scopus 로고    scopus 로고
    • Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD
    • Jacoby E, Yang Y, Qin H, Chien CD, Kochenderfer JN, Fry TJ. Murine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD. Blood. 2016;127:1361–1370.
    • (2016) Blood , vol.127 , pp. 1361-1370
    • Jacoby, E.1    Yang, Y.2    Qin, H.3    Chien, C.D.4    Kochenderfer, J.N.5    Fry, T.J.6
  • 288
    • 84926433030 scopus 로고    scopus 로고
    • Improving the safety of cell therapy products by suicide gene transfer
    • Jones BS, Lamb LS, Goldman F, Di Stasi A. Improving the safety of cell therapy products by suicide gene transfer. Front Pharmacol. 2014;5:254.
    • (2014) Front Pharmacol , vol.5 , pp. 254
    • Jones, B.S.1    Lamb, L.S.2    Goldman, F.3    Di Stasi, A.4
  • 289
    • 84908700977 scopus 로고    scopus 로고
    • The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells
    • Gargett T, Brown MP. The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells. Front Pharmacol. 2014;5:235.
    • (2014) Front Pharmacol , vol.5 , pp. 235
    • Gargett, T.1    Brown, M.P.2
  • 291
    • 69549124480 scopus 로고    scopus 로고
    • + regulatory T cells controlled by the transcription factor Egr-2
    • + regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci USA. 2009;106:13974–13979.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13974-13979
    • Okamura, T.1    Fujio, K.2    Shibuya, M.3
  • 292
    • 84960090962 scopus 로고    scopus 로고
    • Lymphocyte-activation gene 3(+) (LAG3(+)) forkhead box protein 3(-) (FOXP3(-)) regulatory T cells induced by B cells alleviates joint inflammation in collagen-induced arthritis
    • Chen SY, Hsu WT, Chen YL, Chien CH, Chiang BL. Lymphocyte-activation gene 3(+) (LAG3(+)) forkhead box protein 3(-) (FOXP3(-)) regulatory T cells induced by B cells alleviates joint inflammation in collagen-induced arthritis. J Autoimmun. 2016;68:75–85.
    • (2016) J Autoimmun , vol.68 , pp. 75-85
    • Chen, S.Y.1    Hsu, W.T.2    Chen, Y.L.3    Chien, C.H.4    Chiang, B.L.5
  • 293
    • 84953217393 scopus 로고    scopus 로고
    • + regulatory T cell-suppressive function and therapeutic efficacy
    • + regulatory T cell-suppressive function and therapeutic efficacy. Mucosal Immunol. 2016;9:137–145.
    • (2016) Mucosal Immunol , vol.9 , pp. 137-145
    • Do, J.S.1    Visperas, A.2    Sanogo, Y.O.3
  • 294
    • 84899921390 scopus 로고    scopus 로고
    • Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation
    • Sega EI, Leveson-Gower DB, Florek M, Schneidawind D, Luong RH, Negrin RS. Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation. PLoS ONE. 2014;9:e86551.
    • (2014) PLoS ONE , vol.9
    • Sega, E.I.1    Leveson-Gower, D.B.2    Florek, M.3    Schneidawind, D.4    Luong, R.H.5    Negrin, R.S.6
  • 295
    • 14744305769 scopus 로고    scopus 로고
    • B7-H3 promotes acute and chronic allograft rejection
    • Wang L, Fraser CC, Kikly K, et al. B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol. 2005;35:428–438.
    • (2005) Eur J Immunol , vol.35 , pp. 428-438
    • Wang, L.1    Fraser, C.C.2    Kikly, K.3
  • 296
    • 84865750116 scopus 로고    scopus 로고
    • Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses
    • Ueno T, Yeung MY, McGrath M, et al. Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur J Immunol. 2012;42:2343–2353.
    • (2012) Eur J Immunol , vol.42 , pp. 2343-2353
    • Ueno, T.1    Yeung, M.Y.2    McGrath, M.3
  • 297
    • 84979860701 scopus 로고    scopus 로고
    • B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality
    • Veenstra RG, Flynn R, Kreymborg K, et al. B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality. Blood. 2015;125:3335–3346.
    • (2015) Blood , vol.125 , pp. 3335-3346
    • Veenstra, R.G.1    Flynn, R.2    Kreymborg, K.3
  • 298
    • 34547894233 scopus 로고    scopus 로고
    • + regulatory T cells: Role of B7-H3 expression and antigen presentation
    • + regulatory T cells: Role of B7-H3 expression and antigen presentation. Eur J Immunol. 2007;37:2117–2126.
    • (2007) Eur J Immunol , vol.37 , pp. 2117-2126
    • Mahnke, K.1    Ring, S.2    Johnson, T.S.3
  • 299
    • 77957205276 scopus 로고    scopus 로고
    • In vivo function of immune inhibitory molecule B7-H4 in alloimmune responses
    • Yamaura K, Watanabe T, Boenisch O, et al. In vivo function of immune inhibitory molecule B7-H4 in alloimmune responses. Am J Transplant. 2010;10:2355–2362.
    • (2010) Am J Transplant , vol.10 , pp. 2355-2362
    • Yamaura, K.1    Watanabe, T.2    Boenisch, O.3
  • 300
    • 77954674575 scopus 로고    scopus 로고
    • + T cells is linked to antigen recognition and T cell differentiation
    • + T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog. 2010;6:e1000947.
    • (2010) PLoS Pathog , vol.6
    • Bengsch, B.1    Seigel, B.2    Ruhl, M.3
  • 301
    • 57849168934 scopus 로고    scopus 로고
    • + T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • + T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009;10:29–37.
    • (2009) Nat Immunol , vol.10 , pp. 29-37
    • Blackburn, S.D.1    Shin, H.2    Haining, W.N.3
  • 303
    • 35349014587 scopus 로고    scopus 로고
    • + T cell exhaustion during chronic viral infection
    • + T cell exhaustion during chronic viral infection. Immunity. 2007;27:670–684.
    • (2007) Immunity , vol.27 , pp. 670-684
    • Wherry, E.J.1    Ha, S.J.2    Kaech, S.M.3
  • 304
    • 79960419919 scopus 로고    scopus 로고
    • Cutting edge: An NK cell-independent role for Slamf4 in controlling humoral autoimmunity
    • Brown DR, Calpe S, Keszei M, et al. Cutting edge: An NK cell-independent role for Slamf4 in controlling humoral autoimmunity. J Immunol. 2011;187:21–25.
    • (2011) J Immunol , vol.187 , pp. 21-25
    • Brown, D.R.1    Calpe, S.2    Keszei, M.3
  • 305
    • 77952212719 scopus 로고    scopus 로고
    • Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus
    • Kim JR, Mathew SO, Patel RK, Pertusi RM, Mathew PA. Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus. Clin Exp Immunol. 2010;160:348–358.
    • (2010) Clin Exp Immunol , vol.160 , pp. 348-358
    • Kim, J.R.1    Mathew, S.O.2    Patel, R.K.3    Pertusi, R.M.4    Mathew, P.A.5
  • 306
    • 0242539820 scopus 로고    scopus 로고
    • Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    • Sabatos CA, Chakravarti S, Cha E, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003;4:1102–1110.
    • (2003) Nat Immunol , vol.4 , pp. 1102-1110
    • Sabatos, C.A.1    Chakravarti, S.2    Cha, E.3
  • 307
    • 0242708767 scopus 로고    scopus 로고
    • Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    • Sanchez-Fueyo A, Tian J, Picarella D, et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003;4:1093–1101.
    • (2003) Nat Immunol , vol.4 , pp. 1093-1101
    • Sanchez-Fueyo, A.1    Tian, J.2    Picarella, D.3
  • 308
    • 84864129808 scopus 로고    scopus 로고
    • Contrasting acute graft-versushost disease effects of TIM-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells
    • Veenstra RG, Taylor PA, Zhou Q, et al. Contrasting acute graft-versushost disease effects of TIM-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012;120:682–690.
    • (2012) Blood , vol.120 , pp. 682-690
    • Veenstra, R.G.1    Taylor, P.A.2    Zhou, Q.3
  • 309
    • 40849083349 scopus 로고    scopus 로고
    • Activation of Tim-3Galectin-9 pathway improves survival of fully allogeneic skin grafts
    • Wang F, He W, Yuan J, et al. Activation of Tim-3Galectin-9 pathway improves survival of fully allogeneic skin grafts. Transpl Immunol. 2008;19:12–19.
    • (2008) Transpl Immunol , vol.19 , pp. 12-19
    • Wang, F.1    He, W.2    Yuan, J.3
  • 310
    • 41249096396 scopus 로고    scopus 로고
    • + alloreactive T cell and prolongs survival of skin graft
    • + alloreactive T cell and prolongs survival of skin graft. Cell Immunol. 2007;250:68–74.
    • (2007) Cell Immunol , vol.250 , pp. 68-74
    • Wang, F.1    He, W.2    Zhou, H.3
  • 311
    • 70350552096 scopus 로고    scopus 로고
    • Galectin-9 significantly prolongs the survival of fully mismatched cardiac allografts in mice
    • He W, Fang Z, Wang F, et al. Galectin-9 significantly prolongs the survival of fully mismatched cardiac allografts in mice. Transplantation. 2009;88:782–790.
    • (2009) Transplantation , vol.88 , pp. 782-790
    • He, W.1    Fang, Z.2    Wang, F.3
  • 312
    • 78650635632 scopus 로고    scopus 로고
    • TIM-3: A novel regulatory molecule of alloimmune activation
    • Boenisch O, D'Addio F, Watanabe T, et al. TIM-3: A novel regulatory molecule of alloimmune activation. J Immunol. 2010;185:5806–5819.
    • (2010) J Immunol , vol.185 , pp. 5806-5819
    • Boenisch, O.1    D'Addio, F.2    Watanabe, T.3
  • 314
    • 84939439432 scopus 로고    scopus 로고
    • Galectin-9 in combination with EX-527 prolongs the survival of cardiac allografts in mice after cardiac transplantation
    • Tao YF, Lin F, Yan XY, et al. Galectin-9 in combination with EX-527 prolongs the survival of cardiac allografts in mice after cardiac transplantation. Transplant Proc. 2015;47:2003–2009.
    • (2015) Transplant Proc , vol.47 , pp. 2003-2009
    • Tao, Y.F.1    Lin, F.2    Yan, X.Y.3
  • 315
    • 84883460463 scopus 로고    scopus 로고
    • Galectin-9 in combination with rapamycin induces cardiac allograft tolerance in mice
    • Cai L, Zhou H, Fang Z, et al. Galectin-9 in combination with rapamycin induces cardiac allograft tolerance in mice. Transplantation. 2013;96:379–386.
    • (2013) Transplantation , vol.96 , pp. 379-386
    • Cai, L.1    Zhou, H.2    Fang, Z.3
  • 316
    • 84877154846 scopus 로고    scopus 로고
    • Galectin9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts
    • Shimmura-Tomita M, Wang M, Taniguchi H, Akiba H, Yagita H, Hori J. Galectin9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts. PLoS ONE. 2013;8:e63620.
    • (2013) PLoS ONE , vol.8
    • Shimmura-Tomita, M.1    Wang, M.2    Taniguchi, H.3    Akiba, H.4    Yagita, H.5    Hori, J.6
  • 317
    • 80054729067 scopus 로고    scopus 로고
    • Immunomodulatory effects induced by cytotoxic T lymphocyte antigen 4 immunoglobulin with donor peripheral blood mononuclear cell infusion in canine major histocompatibility complex-haplo-identical non-myeloablative hematopoietic cell transplantation
    • Chen Y, Fukuda T, Thakar MS, et al. Immunomodulatory effects induced by cytotoxic T lymphocyte antigen 4 immunoglobulin with donor peripheral blood mononuclear cell infusion in canine major histocompatibility complex-haplo-identical non-myeloablative hematopoietic cell transplantation. Cytotherapy. 2011;13:1269–1280.
    • (2011) Cytotherapy , vol.13 , pp. 1269-1280
    • Chen, Y.1    Fukuda, T.2    Thakar, M.S.3
  • 318
    • 69449102886 scopus 로고    scopus 로고
    • Establishment of long-term tolerance to SRBC in dogs by recombinant canine CTLA4-Ig
    • Graves SS, Stone D, Loretz C, et al. Establishment of long-term tolerance to SRBC in dogs by recombinant canine CTLA4-Ig. Transplantation. 2009;88:317–322.
    • (2009) Transplantation , vol.88 , pp. 317-322
    • Graves, S.S.1    Stone, D.2    Loretz, C.3
  • 319
    • 79954646791 scopus 로고    scopus 로고
    • Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: Tools for allogeneic transplantation
    • Graves SS, Stone DM, Loretz C, et al. Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: Tools for allogeneic transplantation. Transplantation. 2011;91:833–840.
    • (2011) Transplantation , vol.91 , pp. 833-840
    • Graves, S.S.1    Stone, D.M.2    Loretz, C.3
  • 320
    • 84858403778 scopus 로고    scopus 로고
    • Tolerance to vascularized composite allografts in canine mixed hematopoietic chimeras
    • Mathes DW, Hwang B, Graves SS, et al. Tolerance to vascularized composite allografts in canine mixed hematopoietic chimeras. Transplantation. 2011;92:1301–1308.
    • (2011) Transplantation , vol.92 , pp. 1301-1308
    • Mathes, D.W.1    Hwang, B.2    Graves, S.S.3
  • 321
    • 85014325995 scopus 로고    scopus 로고
    • Anti-CD28 antibody-initiated cytokine storm in canines
    • Rosinski SL, Storb R, Strong RK, et al. Anti-CD28 antibody-initiated cytokine storm in canines. Transplant Direct. 2015;1. doi:10.1097/TXD.0000000000000516.
    • (2015) Transplant Direct , vol.1
    • Rosinski, S.L.1    Storb, R.2    Strong, R.K.3
  • 322
    • 33846308903 scopus 로고    scopus 로고
    • CD154 blockade and donorspecific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1 Gy total body irradiation
    • Jochum C, Beste M, Zellmer E, Graves SS, Storb R. CD154 blockade and donorspecific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1 Gy total body irradiation. Biol Blood Marrow Transplant. 2007;13:164–171.
    • (2007) Biol Blood Marrow Transplant , vol.13 , pp. 164-171
    • Jochum, C.1    Beste, M.2    Zellmer, E.3    Graves, S.S.4    Storb, R.5
  • 323
    • 84859420445 scopus 로고    scopus 로고
    • Nonhuman primate transplant models finally evolve: Detailed immunogenetic analysis creates new models and strengthens the old
    • Kean LS, Singh K, Blazar BR, Larsen CP. Nonhuman primate transplant models finally evolve: Detailed immunogenetic analysis creates new models and strengthens the old. Am J Transplant. 2012;12:812–819.
    • (2012) Am J Transplant , vol.12 , pp. 812-819
    • Kean, L.S.1    Singh, K.2    Blazar, B.R.3    Larsen, C.P.4
  • 324
    • 0033519661 scopus 로고    scopus 로고
    • Transplantation of anergic histoincompatible bone marrow allografts
    • Guinan EC, Boussiotis VA, Neuberg D, et al. Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med. 1999;340:1704–1714.
    • (1999) N Engl J Med , vol.340 , pp. 1704-1714
    • Guinan, E.C.1    Boussiotis, V.A.2    Neuberg, D.3
  • 326
    • 77956302693 scopus 로고    scopus 로고
    • Primate testing of TGN1412: Right target, wrong cell
    • Pallardy M, Hunig T. Primate testing of TGN1412: Right target, wrong cell. Br J Pharmacol. 2010;161:509–511.
    • (2010) Br J Pharmacol , vol.161 , pp. 509-511
    • Pallardy, M.1    Hunig, T.2
  • 327
    • 0036135578 scopus 로고    scopus 로고
    • Development and homeostasis of T cell memory in rhesus macaque
    • Pitcher CJ, Hagen SI, Walker JM, et al. Development and homeostasis of T cell memory in rhesus macaque. J Immunol. 2002;168:29–43.
    • (2002) J Immunol , vol.168 , pp. 29-43
    • Pitcher, C.J.1    Hagen, S.I.2    Walker, J.M.3
  • 328
    • 84899719315 scopus 로고    scopus 로고
    • Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28
    • Poirier N, Mary C, Le Bas-Bernardet S, et al. Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28. mAbs. 2014;6:697–707.
    • (2014) mAbs , vol.6 , pp. 697-707
    • Poirier, N.1    Mary, C.2    Le Bas-Bernardet, S.3
  • 329
    • 0033529235 scopus 로고    scopus 로고
    • Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
    • Kenyon NS, Chatzipetrou M, Masetti M, et al. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc Natl Acad Sci USA. 1999;96:8132–8137.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8132-8137
    • Kenyon, N.S.1    Chatzipetrou, M.2    Masetti, M.3
  • 330
    • 0028860210 scopus 로고
    • Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys
    • Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation. 1995;59:256–262.
    • (1995) Transplantation , vol.59 , pp. 256-262
    • Kawai, T.1    Cosimi, A.B.2    Colvin, R.B.3
  • 331
    • 0030987616 scopus 로고    scopus 로고
    • Modifications of the conditioning regimen for achieving mixed chimerism and donorspecific tolerance in cynomolgus monkeys
    • Kimikawa M, Sachs DH, Colvin RB, Bartholomew A, Kawai T, Cosimi AB. Modifications of the conditioning regimen for achieving mixed chimerism and donorspecific tolerance in cynomolgus monkeys. Transplantation. 1997;64:709–716.
    • (1997) Transplantation , vol.64 , pp. 709-716
    • Kimikawa, M.1    Sachs, D.H.2    Colvin, R.B.3    Bartholomew, A.4    Kawai, T.5    Cosimi, A.B.6
  • 332
    • 0037333857 scopus 로고    scopus 로고
    • Group BGLNT. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • Boumpas DT, Furie R, Manzi S, et al. Group BGLNT. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum. 2003;48:719–727.
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3
  • 333
    • 84860821730 scopus 로고    scopus 로고
    • Immunogenetic Management Software: A new tool for visualization and analysis of complex immunogenetic datasets
    • Johnson ZP, Eady RD, Ahmad SF, et al. Immunogenetic Management Software: A new tool for visualization and analysis of complex immunogenetic datasets. Immunogenetics. 2012;64:329–336.
    • (2012) Immunogenetics , vol.64 , pp. 329-336
    • Johnson, Z.P.1    Eady, R.D.2    Ahmad, S.F.3
  • 334
    • 70449134621 scopus 로고    scopus 로고
    • Major histocompatibility complex genotyping with massively parallel pyrosequencing
    • Wiseman RW, Karl JA, Bimber BN, et al. Major histocompatibility complex genotyping with massively parallel pyrosequencing. Nat Med. 2009;15:1322–1326.
    • (2009) Nat Med , vol.15 , pp. 1322-1326
    • Wiseman, R.W.1    Karl, J.A.2    Bimber, B.N.3
  • 335
    • 85003348909 scopus 로고    scopus 로고
    • A new rhesus macaque assembly and annotation for next-generation sequencing analyses
    • Zimin AV, Cornish AS, Maudhoo MD, et al. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Biol Direct. 2014;9:20.
    • (2014) Biol Direct , vol.9 , pp. 20
    • Zimin, A.V.1    Cornish, A.S.2    Maudhoo, M.D.3
  • 336
    • 85014418523 scopus 로고    scopus 로고
    • Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and man
    • Furlan SN, Watkins B, Tkachev V, et al. Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and man. Blood. 2016; doi:10.1182/blood-2016-07-726547.
    • (2016) Blood
    • Furlan, S.N.1    Watkins, B.2    Tkachev, V.3
  • 337
    • 84954450570 scopus 로고    scopus 로고
    • Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention
    • Furlan SN, Watkins B, Tkachev V, et al. Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention. Sci Transl Med. 2015;7:315ra191.
    • (2015) Sci Transl Med , vol.7 , pp. 315ra191
    • Furlan, S.N.1    Watkins, B.2    Tkachev, V.3
  • 338
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature. 1953;172:603–606.
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3


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