Tolerance to vascularized composite allografts in canine mixed hematopoietic chimeras

Transplantation

Volumn 92, Issue 12, 2011, Pages 1301-1308

  Mathes, David W ^a,b,d   Hwang, Billanna ^a   Graves, Scott S ^a,c   Edwards, James ^b   Chang, Jeff ^a,b   Storer, Barry E ^a,c   Butts Miwongtum, Tiffany ^a   Sale, George E ^a,c   Nash, Richard A ^a,c   Storb, Rainer ^a,c  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

CTA transplantation; Dog; FoxP3; Hematopoietic cell transplantation; Mixed hematopoietic chimerism; Nonmyeloablative conditioning regimen; Skin grafting; Tolerance; Vascularized Composite Allograft

Indexed keywords

CD3 ANTIGEN; GRANZYME B; TRANSCRIPTION FACTOR FOXP3;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELLULAR DISTRIBUTION; CHIMERA; COMPOSITE GRAFT; CONTROLLED STUDY; DOG; GRAFT RECIPIENT; GRAFT REJECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE COUNT; MUSCLE BIOPSY; NONHUMAN; NONMYELOABLATIVE CONDITIONING; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN BIOPSY; SKIN BLOOD FLOW; WHOLE BODY RADIATION; ALLOTRANSPLANTATION; ANGIOGENESIS; ANIMAL; BONE MARROW TRANSPLANTATION; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT;

ANIMALS; BONE MARROW TRANSPLANTATION; CHIMERA; DOGS; GRAFT REJECTION; IMMUNE TOLERANCE; NEOVASCULARIZATION, PHYSIOLOGIC; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; WHOLE-BODY IRRADIATION;

EID: 84858403778     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318237d6d4     Document Type: Article

References (50)

1. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
2. Kasiske BL, Snyder JJ, Gilbertson DT, et al. Cancer after kidney transplantation in the United States. Am J Transplant 2004; 4: 905.
3. Sykes M. Immune tolerance: Mechanisms and application in clinical transplantation (Review). J Intern Med 2007; 262: 288.
4. Guttmann RD, Santos GW, Lindquist RR. Acceptance of renal allografts in rat bone marrow chimeras. Transplantation 1971; 12: 408.
5. Colson YL, Zadach K, Nalesnik M, et al. Mixed allogeneic chimerism in the rat. Donor-specific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts. Transplantation 1995; 60: 971.
6. Luo B, Nanji SA, Schur CD, et al. Robust tolerance to fully allogeneic islet transplants achieved by chimerism with minimal conditioning. Transplantation 2005; 80: 370.
7. Steinmuller D. Skin allograft rejection by stable hematopoietic chimeras that accept organ allografts still is an enigma [Letter]. Transplantation 2001; 72: 8.
8. Huang CA, Fuchimoto Y, Scheier-Dolberg R, et al. Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model. J Clin Invest 2000; 105: 173.
9. Fuchimoto Y, Gleit ZL, Huang CA, et al. Skin-specific alloantigens in miniature swine. Transplantation 2001; 72: 122.
10. Mathes DW, Randolph MA, Solari MG, et al. Split tolerance to a composite tissue allograft in a swine model. Transplantation 2003; 75: 25.
11. Hettiaratchy S, Melendy E, Randolph MA, et al. Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation 2004; 77: 514.
12. Horner BM, Randolph MA, Duran-Struuck R, et al. Induction of tolerance to an allogeneic skin flap transplant in a preclinical large animal model. Transplant Proc 2009; 41: 539.
13. Kuo YR, Chen CC, Shih HS, et al. Prolongation of composite tissue allotransplant survival by treatment with bone marrow mesenchymal stem cells is correlated with T-cell regulation in a swine hind-limb model. Plast Reconstr Surg 2011; 127: 569.
14. Kuo YR, Goto S, Shih HS, et al. Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model. Transplantation 2009; 87: 1769.
15. Moseley RV, Sheil AG, Mitchell RM, et al. Immunologic relationships between skin and kidney homografts in dogs on immunosuppressive therapy. Transplantation 1966; 4: 678.
16. Steinmuller D, Lofgreen JS. Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen. Nature 1974; 248: 796.
17. Storb R, Yu C, Wagner JL, et al. Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood 1997; 89: 3048.
18. Storb R, Yu C, Zaucha JM, et al. Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood 1999; 94: 2523.
19. Kuhr CS, Allen MD, Junghanss C, et al. Tolerance to vascularized kidney grafts in canine mixed hematopoietic chimeras. Transplantation 2002; 73: 1487.
20. Kuhr CS, Yunusov M, Sale G, et al. Long-term tolerance to kidney allografts in a preclinical canine model. Transplantation 2007; 84: 545.
21. Yunusov MY, Kuhr C, Georges GE, et al. Survival of small bowel transplants in canine mixed hematopoietic chimeras: Preliminary Results: Transplant Proc 2002; 34: 3366.
22. Bozulic LD, Wen Y, Xu H, et al. Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants. Transplantation 2011; 91: 908.
23. Lantieri L, Meningaud JP, Grimbert P, et al. Repair of the lower and middle parts of the face by composite tissue allotransplantation in a patient with massive plexiform neurofibroma: A 1-year follow-up study. Lancet 2008; 372: 639.
24. Lanzetta M, Petruzzo P, Margreiter R, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation 2005; 79: 1210.
25. Siemionow M, Papay F, Alam D, et al. Near-total human face transplantation for a severely disfigured patient in the USA [Review]. Lancet 2009; 374: 203.
26. Breidenbach WC, Gonzales NR, Kaufman CL, et al. Outcomes of the first 2 American hand transplants at 8 and 6 years posttransplant. J Hand Surg Am 2008; 33: 1039.
27. Guo S, Han Y, Zhang X, et al. Human facial allotransplantation: A 2-year follow-up study. Lancet 2008; 372: 631.
28. Brandacher G, Ninkovic M, Piza-Katzer H, et al. The Innsbruck hand transplant program: Update at 8 years after the first transplant. Transplant Proc 2009; 41: 491.
29. Whitaker IS, Duggan EM, Alloway RR, et al. Composite tissue allotransplantation: A review of relevant immunological issues for plastic surgeons [Review]. J Plast Reconstr Aesthet Surg 2008; 61: 481.
30. Hettiaratchy S, Randolph MA, Petit F, et al. Composite tissue allotransplantation-A new era in plastic surgery? (Review). Br J Plast Surg 2004; 57: 381.
31. Wekerle T, Sykes M. Mixed chimerism and transplantation tolerance [Review]. Annu Rev Med 2001; 52: 353.
32. Schroeder ML, Storb R, Graham TC, et al. Canine radiation chimeras: An attempt to demonstrate serum blocking factors by an in vivo approach. J Immunol 1975; 114: 540.
33. Junghanss C, Takatu A, Little M-T, et al. Adoptive immunotherapy against kidney targets in dog-leukocyte antigen-identical mixed hematopoietic canine chimeras. Transplantation 2003; 75: 268.
34. Graves SS, Hogan WJ, Kuhr C, et al. Adoptive immunotherapy against allogeneic kidney grafts in dogs with stable hematopoietic trichimerism. Biol Blood Marrow Transplant 2008; 14: 1201.
35. Storb R, Rudolph RH, Thomas ED. Marrow grafts between canine siblings matched by serotyping and mixed leukocyte culture. J Clin Invest 1971; 50: 1272.
36. Zhang Z, Zhu L, Quan D, et al. Pattern of liver, kidney, heart, and intestine allograft rejection in different mouse strain combinations. Transplantation 1996; 62: 1267.
37. Prop J, Nieuwenhuis P, Wildevuur CR. Lung allograft rejection in the rat. I. Accelerated rejection caused by graft lymphocytes. Transplantation 1985; 40: 25.
38. Mahnke K, Ring S, Bedke T, et al. Interaction of regulatory T cells with antigen-presenting cells in health and disease (Review). Chem Immunol Allergy 2008; 94: 29.
39. Eljaafari A, Badet L, Kanitakis J, et al. Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation. Transplantation 2006; 82: 1764.
40. Fondi C, Nozzoli C, Benemei S, et al. Increase in FOXP3+ regulatory T cells in GVHD skin biopsies is associated with lower disease severity and treatment response. Biol Blood Marrow Transplant 2009; 15: 938.
41. Nash RA, Yunusov M, Abrams K, et al. Immunomodulatory effects of mixed hematopoietic chimerism: Immune tolerance in canine model of lung transplantation. Am J Transplant 2009; 9: 1037.
42. Graves SS, Stone DM, Loretz C, et al. Antagonistic and agonistic anticanine CD28 monoclonal antibodies: Tools for allogeneic transplantation. Transplantation 2011; 91: 833.
43. Muthukumar T, Dadhania D, Ding R, et al. MessengerRNAfor FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005; 353: 2342.
44. Wagner JL, Burnett RC, Storb R. Molecular analysis of the DLA DR region. Tissue Antigens 1996; 48: 549.
45. Wagner JL, Hayes-Lattin B, Works JD, et al. Molecular analysis and polymorphism of the DLA-DQB genes. Tissue Antigens 1998; 52: 242.
46. Ladiges WC, Storb R, Thomas ED. Canine models of bone marrow transplantation. Lab Anim Sci 1990; 40: 11.
47. Yu C, Ostrander E, Bryant E, et al. Use of (CA)n polymorphisms to determine the origin of blood cells after allogeneic canine marrow grafting. Transplantation 1994; 58: 701.
48. Graves SS, Hogan W, Kuhr CS, et al. Stable trichimerism after marrow grafting from 2 DLA-identical canine donors and nonmyeloablative conditioning. Blood 2007; 110: 418.
49. Mathes DW, Noland M, Graves S, et al. A preclinical canine model for composite tissue transplantation. J Reconstr Microsurg 2010; 26: 201.
50. Raff RF, Deeg HJ, Farewell VT, et al. The canine major histocompatibility complex. Population study of DLA-D alleles using a panel of homozygous typing cells. Tissue Antigens 1983; 21: 360.