An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching

American Journal of Transplantation

Volumn 10, Issue 11, 2010, Pages 2396-2409

  Larsen, C P ^a   Page, A ^a   Linzie, K H ^a   Russell, M ^a   Deane, T ^a   Stempora, L ^a   Strobert, E ^b   Penedo, M C T ^c   Ward, T ^c   Wiseman, R ^d   OConnor, D ^d   Miller, W ^e,f   Sen, S ^a   Singh, K ^a   Kean, L S ^a,e  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF WISCONSIN   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

chimerism; co stimulation blockade resistant rejection; tolerance induction

Indexed keywords

BASILIXIMAB; BUSULFAN; RAPAMYCIN;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ARTICLE; BLOOD GROUP TYPING; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CHIMERA; CONTROLLED STUDY; DISEASE ASSOCIATION; ENGRAFTMENT; FEMALE; GRAFT REJECTION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE COUNT; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NONHUMAN; NONMYELOABLATIVE STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; RHESUS MONKEY; T LYMPHOCYTE;

ANIMALS; BUSULFAN; FEMALE; GRAFT REJECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; MACACA MULATTA; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; SIROLIMUS; SUBSTANCE WITHDRAWAL SYNDROME; T-LYMPHOCYTES; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING;

EID: 78349239341     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2010.03272.x     Document Type: Article

References (25)

1. Adams AB, Durham MM, Kean L, et al,. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. J Immunol 2001; 167: 1103 -1111.
2. Durham MM, Bingaman AW, Adams AB, et al,. Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol 2000; 165: 1 -4.
3. Kean LS, Durham MM, Adams AB, et al,. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood 2002; 99: 1840 -1849.
4. Larsen CP, Elwood ET, Alexander DZ, et al,. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434 -438.
5. Sharabi Y, Abraham VS, Sykes M, Sachs DH,. Mixed allogeneic chimeras prepared by a non-myeloablative regimen: Requirement for chimerism to maintain tolerance. Bone Marrow Transplant 1992; 9: 191 -197.
6. Sykes M, Szot GL, Swenson KA, Pearson DA,. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat Med 1997; 3: 783 -787.
7. Tomita Y, Sachs DH, Sykes M,. Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. Blood 1994; 83: 939 -948.
8. Kawai T, Cosimi AB, Colvin RB, et al,. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59: 256 -262.
9. Kawai T, Sogawa H, Boskovic S, et al,. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant 2004; 4: 1391 -1398.
10. Aoyama A, Ng CY, Millington TM, et al,. Comparison of lung and kidney allografts in induction of tolerance by a mixed-chimerism approach in cynomolgus monkeys. Transplant Proc 2009; 41: 429 -430.
11. Kawai T, Cosimi AB, Spitzer TR, et al,. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358: 353 -361.
12. Scandling JD, Busque S, Dejbakhsh-Jones S, et al,. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008; 358: 362 -368.
13. Kirk AD,. Clinical tolerance 2008. Transplantation 2009; 87: 953 -955.
14. Kean LS, Gangappa S, Pearson TC, Larsen CP,. Transplant tolerance in non-human primates: Progress, current challenges and unmet needs. Am J Transplant 2006; 6 (5 Pt 1): 884 -893.
15. Kirk AD,. Crossing the bridge: Large animal models in translational transplantation research. Immunol Rev 2003; 196: 176 -196.
16. Kean LS, Adams AB, Strobert E, et al,. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. Am J Transplant 2007; 7: 320 -335.
17. Penedo MC, Bontrop RE, Heijmans CM, et al,. Microsatellite typing of the rhesus macaque MHC region. Immunogenetics 2005; 57: 198 -209.
18. Pitcher CJ, Hagen SI, Walker JM, et al,. Development and homeostasis of T cell memory in rhesus macaque. J Immunol 2002; 168: 29 -43.
19. Bensinger WI, Storb R,. Allogeneic peripheral blood stem cell transplantation. Rev Clin Exp Hematol 2001; 5: 67 -86.
20. Kasai M, Kiyama Y, Kawamura A,. Application of peripheral blood stem cells (PBSC) mobilized by recombinant human granulocyte colony stimulating factor for allogeneic PBSC transplantation and the comparison of allogeneic PBSC transplantation and bone marrow transplantation. Transfus Apher Sci 2002; 26: 121 -127.
21. Russell NH, Byrne JL,. Allogeneic transplantation using peripheral blood stem cells. Best Pract Res Clin Haematol 2001; 14: 685 -700.
22. Spierings E, Vermeulen CJ, Vogt MH, et al,. Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4+ T-helper cells in H-Y-mismatched transplantation. Lancet 2003; 362: 610 -615.
23. Andrade MC, Penedo MC, Ward T, et al,. Determination of genetic status in a closed colony of rhesus monkeys (Macaca mulatta). Primates 2004; 45: 183 -186.
24. OLeary CE, Wiseman RW, Karl JA, et al,. Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing. Immunogenetics 2009; 61: 689 -701.
25. Wiseman RW, Karl JA, Bimber BN, et al,. Major histocompatibility complex genotyping with massively parallel pyrosequencing. Nat Med 2009; 15: 1322 -1326.