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Volumn 22, Issue 6, 2015, Pages 509-515

Challenges and opportunities of allogeneic donorderived CAR T cells

Author keywords

Adoptive immunotherapy; Allogeneic hematopoietic stem cell transplantation; Chimeric antigen receptors; Donor derived; Graft versus host disease

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84944079434     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000181     Document Type: Review
Times cited : (80)

References (76)
  • 1
    • 0018764352 scopus 로고
    • Antileukemic effect of graft-versushost disease in human recipients of allogeneic-marrow grafts
    • Weiden PL, Flournoy N, Thomas ED, et al. Antileukemic effect of graft-versushost disease in human recipients of allogeneic-marrow grafts. N Engl J Med 1979; 300:1068-1073.
    • (1979) N Engl J Med , vol.300 , pp. 1068-1073
    • Weiden, P.L.1    Flournoy, N.2    Thomas, E.D.3
  • 2
    • 0018649386 scopus 로고
    • Marrow transplantation lymphoblastic for leukemia patients with in remission
    • Thomas ED, Sanders J, Flournoy N, et al. Marrow transplantation lymphoblastic for leukemia patients with in remission. Blood 1979; 54:468-477.
    • (1979) Blood , vol.54 , pp. 468-477
    • Thomas, E.D.1    Sanders, J.2    Flournoy, N.3
  • 3
    • 0025100777 scopus 로고
    • Graft-versus-leukemia reactions after bone marrow transplantation
    • Horowitz MM, Gale RP, Sondel PM, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75:555-562.
    • (1990) Blood , vol.75 , pp. 555-562
    • Horowitz, M.M.1    Gale, R.P.2    Sondel, P.M.3
  • 4
    • 2942712161 scopus 로고    scopus 로고
    • Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation
    • Collins RH, Shpilberg O, Drobyski W, et al. Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J Clin Oncol 1997; 15:433-444.
    • (1997) J Clin Oncol , vol.15 , pp. 433-444
    • Collins, R.H.1    Shpilberg, O.2    Drobyski, W.3
  • 5
    • 36849048316 scopus 로고    scopus 로고
    • Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: A retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukem
    • Schmid C, Labopin M, Nagler A, et al. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: A retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukem. J Clin Oncol 2007.
    • (2007) J Clin Oncol , vol.25 , pp. 4938-4945
    • Schmid, C.1    Labopin, M.2    Nagler, A.3
  • 6
    • 50049106424 scopus 로고    scopus 로고
    • Population, Donor leukocyte infusions to treat hematologic malignancy relapse following allo-SCT in a pediatric
    • Levine JE, Barrett AJ, Zhang M-J, et al. Donor leukocyte infusions to treat hematologic malignancy relapse following allo-SCT in a pediatric population. Bone Marrow Transplant 2008; 42:201-205.
    • (2008) Bone Marrow Transplant , vol.42 , pp. 201-205
    • Levine, J.E.1    Barrett, A.J.2    Zhang, M.-J.3
  • 7
    • 84879350571 scopus 로고    scopus 로고
    • Outcomes of adults with acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation
    • Poon LM, Hamdi A, Saliba R, et al. Outcomes of adults with acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2013; 19:1059-1064.
    • (2013) Biol Blood Marrow Transplant , vol.19 , pp. 1059-1064
    • Poon, L.M.1    Hamdi, A.2    Saliba, R.3
  • 8
    • 84862000695 scopus 로고    scopus 로고
    • Outcomes and prognostic factors of adults with acute lymphoblastic leukemia who relapse after allogeneic hematopoietic cell transplantation. An analysis on behalf of the Acute Leukemia Working Party of EBMT
    • Spyridonidis a, Labopin M, Schmid C, et al. Outcomes and prognostic factors of adults with acute lymphoblastic leukemia who relapse after allogeneic hematopoietic cell transplantation. An analysis on behalf of the Acute Leukemia Working Party of EBMT. Leukemia 2012; 26:1211-1217.
    • (2012) Leukemia , vol.26 , pp. 1211-1217
    • Spyridonidis, A.1    Labopin, M.2    Schmid, C.3
  • 9
    • 33746029948 scopus 로고    scopus 로고
    • Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG- 1941
    • Gaynon PS, Harris RE, Altman AJ, et al. Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG- 1941. J Clin Oncol 2006; 24:3150-3156.
    • (2006) J Clin Oncol , vol.24 , pp. 3150-3156
    • Gaynon, P.S.1    Harris, R.E.2    Altman, A.J.3
  • 10
    • 84861576998 scopus 로고    scopus 로고
    • Advances in graft-versus-host disease biology and therap
    • Blazar B, Murphy W, Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol 2012; 12:443-458.
    • (2012) Nat Rev Immunol , vol.12 , pp. 443-458
    • Blazar, B.1    Murphy, W.2    Abedi, M.3
  • 11
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviè re I. The basic principles of chimeric antigen receptor design. Cancer Discov 2013; 3:388-398.
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Rivière, I.3
  • 12
    • 84927176568 scopus 로고    scopus 로고
    • Fry TJ. Immune-based therapies for childhood cancer
    • Mackall CL, Merchant MS, Fry TJ. Immune-based therapies for childhood cancer. Nat Rev Clin Oncol 2014; 11:693-703.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 693-703
    • Mackall, C.L.1    Merchant, M.S.2
  • 13
    • 84899631361 scopus 로고    scopus 로고
    • Antibody-modified T cells: CARs take the front seat for hematologic malignancies
    • Maus MV, Grupp Sa, Porter DL, June CH. Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Blood 2014; 123:2625- 2635.
    • (2014) Blood , vol.123 , pp. 2625-2635
    • Maus, M.V.1    Grupp, S.2    Porter, D.L.3    June, C.H.4
  • 14
    • 77957756405 scopus 로고    scopus 로고
    • Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells
    • Kochenderfer JN, Yu Z, Frasheri D, et al. Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells. Blood 2010; 116:3875-3886.
    • (2010) Blood , vol.116 , pp. 3875-3886
    • Kochenderfer, J.N.1    Yu, Z.2    Frasheri, D.3
  • 15
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, et al. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011; 365:725-733.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3
  • 16
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp Sa, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013; 368:1509-1518.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.1    Kalos, M.2    Barrett, D.3
  • 17
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
    • Davila ML, Riviere I, Wang X, et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med 2014; 6:224ra25.
    • (2014) Sci Transl Med , vol.6 , pp. 224ra25
    • Davila, M.L.1    Riviere, I.2    Wang, X.3
  • 18
    • 84916895684 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
    • Lee DW, Kochenderfer JN, Stetler-Stevenson M, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial. Lancet 2014; 6736:1-12.
    • (2014) Lancet , vol.6736 , pp. 1-12
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3
  • 19
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude SL, Frey N, Shaw Pa, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 2014; 371:1507- 1517.
    • (2014) N Engl J Med , vol.371 , pp. 1507-1517
    • Maude, S.L.1    Frey, N.2    Shaw, P.3
  • 20
    • 84923118622 scopus 로고    scopus 로고
    • Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
    • Kochenderfer JN, Dudley ME, Kassim SH, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol 2014; 33:540-549.
    • (2014) J Clin Oncol , vol.33 , pp. 540-549
    • Kochenderfer, J.N.1    Dudley, M.E.2    Kassim, S.H.3
  • 21
    • 18144394761 scopus 로고    scopus 로고
    • Immune reconstitution following hematopoietic progenitor cell transplantation: Challenges for the future
    • Fry TJ, Mackall CL. Immune reconstitution following hematopoietic progenitor cell transplantation: challenges for the future. Bone Marrow Transplant 2005; 35 (Suppl 1):S53-S67.
    • (2005) Bone Marrow Transplant , vol.35 , pp. S53-S67
    • Fry, T.J.1    Mackall, C.L.2
  • 22
    • 66549119153 scopus 로고    scopus 로고
    • Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect
    • Capitini CM, Herby S, Milliron M, et al. Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect. Blood 2009; 113:5002-5009.
    • (2009) Blood , vol.113 , pp. 5002-5009
    • Capitini, C.M.1    Herby, S.2    Milliron, M.3
  • 23
    • 84872695582 scopus 로고    scopus 로고
    • Graft-versus-host disease impairs vaccine responses through decreased CD4 and CD8 T cell proliferation and increased perforin-mediated CD8 T cell apoptosis
    • Capitini CM, Nasholm NM, Duncan BB, et al. Graft-versus-host disease impairs vaccine responses through decreased CD4 and CD8 T cell proliferation and increased perforin-mediated CD8 T cell apoptosis. J Immunol 2013; 190:1351-1359.
    • (2013) J Immunol , vol.190 , pp. 1351-1359
    • Capitini, C.M.1    Nasholm, N.M.2    Duncan, B.B.3
  • 24
    • 0037438372 scopus 로고    scopus 로고
    • Tissue distribution of target antigen has a decisive influence on the outcome of adoptive cancer immunotherapy
    • Meunier M, Roy-Proulx G, Labrecque N, Perreault C. Tissue distribution of target antigen has a decisive influence on the outcome of adoptive cancer immunotherapy. Blood 2003; 101:766-770.
    • (2003) Blood , vol.101 , pp. 766-770
    • Meunier, M.1    Roy-Proulx, G.2    Labrecque, N.3    Perreault, C.4
  • 25
    • 84890937525 scopus 로고    scopus 로고
    • Minor antigen distribution predicts sitespecific graft-versus-tumor activity of adoptively transferred, minor antigenspecific CD8 T Cells
    • Shand JC, Qin H, Nasholm N, et al. Minor antigen distribution predicts sitespecific graft-versus-tumor activity of adoptively transferred, minor antigenspecific CD8 T Cells. Biol Blood Marrow Transplant 2014; 20:26-36.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 26-36
    • Shand, J.C.1    Qin, H.2    Nasholm, N.3
  • 26
    • 84885163424 scopus 로고    scopus 로고
    • Potential limitations of the NSG humanized mouse as a model system to optimize engineered human T cell therapy for cancer
    • Alcantar-Orozco EM, Gornall H, Baldan V, et al. Potential limitations of the NSG humanized mouse as a model system to optimize engineered human T cell therapy for cancer. Hum Gene Ther Methods 2013; 24:310-320.
    • (2013) Hum Gene Ther Methods , vol.24 , pp. 310-320
    • Alcantar-Orozco, E.M.1    Gornall, H.2    Baldan, V.3
  • 27
    • 84922578588 scopus 로고    scopus 로고
    • Chimeric antigen receptorredirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity
    • Chan WK, Suwannasaen D, Throm RE, et al. Chimeric antigen receptorredirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity. Leukemia 2015; 29:387-395.
    • (2015) Leukemia , vol.29 , pp. 387-395
    • Chan, W.K.1    Suwannasaen, D.2    Throm, R.E.3
  • 28
    • 79960994829 scopus 로고    scopus 로고
    • Redirected tumor-specific allogeneic T cells for universal treatment of cancer
    • Marcus A, Waks T, Eshhar Z. Redirected tumor-specific allogeneic T cells for universal treatment of cancer. Blood 2011; 118:975-984.
    • (2011) Blood , vol.118 , pp. 975-984
    • Marcus, A.1    Waks, T.2    Eshhar, Z.3
  • 29
    • 84890827981 scopus 로고    scopus 로고
    • Donor-derived CD19- Targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
    • Kochenderfer JN, Dudley ME, Carpenter RO, et al. Donor-derived CD19- Targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood 2013; 122:4129-4139.
    • (2013) Blood , vol.122 , pp. 4129-4139
    • Kochenderfer, J.N.1    Dudley, M.E.2    Carpenter, R.O.3
  • 30
    • 0037085804 scopus 로고    scopus 로고
    • Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: Potential for improved immunotherap
    • Rossig C, Bollard C, Nuchtern J. Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy. Blood 2002; 99:2009-2017.
    • (2002) Blood , vol.99 , pp. 2009-2017
    • Rossig, C.1    Bollard, C.2    Nuchtern, J.3
  • 31
    • 33749514632 scopus 로고    scopus 로고
    • Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
    • Leen AM, Myers GD, Sili U, et al. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med 2006; 12:1160-1166.
    • (2006) Nat Med , vol.12 , pp. 1160-1166
    • Leen, A.M.1    Myers, G.D.2    Sili, U.3
  • 32
    • 80051907647 scopus 로고    scopus 로고
    • Expansion of T cells targeting multiple antigens of cytomegalovirus, Epstein-Barr virus and adenovirus to provide broad antiviral specificity after stem cell
    • Hanley P, Shaffer D, Cruz C, et al. Expansion of T cells targeting multiple antigens of cytomegalovirus, Epstein-Barr virus and adenovirus to provide broad antiviral specificity after stem cell. Cytotherapy 2011; 13:976- 986.
    • (2011) Cytotherapy , vol.13 , pp. 976-986
    • Hanley, P.1    Shaffer, D.2    Cruz, C.3
  • 33
    • 84884178203 scopus 로고    scopus 로고
    • Multicenter study of banked thirdparty virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation
    • Leen AM, Bollard CM, Mendizabal AM, et al. Multicenter study of banked thirdparty virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood 2013; 121:5113-5123.
    • (2013) Blood , vol.121 , pp. 5113-5123
    • Leen, A.M.1    Bollard, C.M.2    Mendizabal, A.M.3
  • 34
    • 34948860624 scopus 로고    scopus 로고
    • Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
    • Savoldo B, Rooney C, Di Stasi A, et al. Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 2007; 110:1-3.
    • (2007) Blood , vol.110 , pp. 1-3
    • Savoldo, B.1    Rooney, C.2    Di Stasi, A.3
  • 35
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells enginerred to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule MA, Savoldo B, Myers GD, et al. Virus-specific T cells enginerred to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med 2009; 14:1264-1270.
    • (2009) Nat Med , vol.14 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3
  • 36
    • 84862954607 scopus 로고    scopus 로고
    • Generation of CD19-chimeric antigen receptor modified CD8 T cells derived from virus-specific central memory T cells
    • Terakura S, Yamamoto TN, Gardner RA, et al. Generation of CD19-chimeric antigen receptor modified CD8 T cells derived from virus-specific central memory T cells. Blood 2012; 119:72-82.
    • (2012) Blood , vol.119 , pp. 72-82
    • Terakura, S.1    Yamamoto, T.N.2    Gardner, R.A.3
  • 37
    • 84977120224 scopus 로고    scopus 로고
    • Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: A Production Assistant for Cell Therapy (PACT) translational application
    • Sun J, Huye LE, Lapteva N, et al. Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: A Production Assistant for Cell Therapy (PACT) translational application. J Immunother Cancer 2015; 3:1-17.
    • (2015) J Immunother Cancer , vol.3 , pp. 1-17
    • Sun, J.1    Huye, L.E.2    Lapteva, N.3
  • 38
    • 84887821770 scopus 로고    scopus 로고
    • Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase 1 study
    • Cruz CRY, Micklethwaite KP, Savoldo B, et al. Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: A phase 1 study. Blood 2013; 122:2965- 2973.
    • (2013) Blood , vol.122 , pp. 2965-2973
    • Cruz, C.R.Y.1    Micklethwaite, K.P.2    Savoldo, B.3
  • 39
    • 84941270746 scopus 로고    scopus 로고
    • Adoptive therapy using sleeping beauty gene transfer system and artificial antigen presenting cells to manufacture T cells expressing CD19-specific chimeric antigen receptor
    • Kebriaei P, Huls H, Singh H, et al. Adoptive therapy using sleeping beauty gene transfer system and artificial antigen presenting cells to manufacture T cells expressing CD19-specific chimeric antigen receptor. Blood 2014; 124:311-1311.
    • (2014) Blood , vol.124 , pp. 311-1311
    • Kebriaei, P.1    Huls, H.2    Singh, H.3
  • 40
    • 0033959105 scopus 로고    scopus 로고
    • Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production
    • Weijtens ME, Hart EH, Bolhuis RL. Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production. Gene Ther 2000; 7:35-42.
    • (2000) Gene Ther , vol.7 , pp. 35-42
    • Weijtens, M.E.1    Hart, E.H.2    Bolhuis, R.L.3
  • 42
    • 77952753137 scopus 로고    scopus 로고
    • Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation
    • James SE, Greenberg PD, Jensen MC, et al. Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulation. J Immunol 2010; 184:4284-4294.
    • (2010) J Immunol , vol.184 , pp. 4284-4294
    • James, S.E.1    Greenberg, P.D.2    Jensen, M.C.3
  • 43
    • 84921473544 scopus 로고    scopus 로고
    • Target antigen density governs the efficacy of anti-CD20-CD28-CD3 chimeric antigen receptor-modified effector CD8 T cells
    • Watanabe K, Terakura S, Martens aC, et al. Target antigen density governs the efficacy of anti-CD20-CD28-CD3 chimeric antigen receptor-modified effector CD8 T cells. J Immunol 2014; 194:911-920.
    • (2014) J, Immunol , vol.194 , pp. 911-920
    • Watanabe, K.1    Terakura, S.2    Martens, A.3
  • 44
    • 0034665510 scopus 로고    scopus 로고
    • Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection
    • Love PE, Lee J, Shores EW. Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection. J Immunol 2000; 165:3080-3087.
    • (2000) J Immunol , vol.165 , pp. 3080-3087
    • Love, P.E.1    Lee, J.2    Shores, E.W.3
  • 45
    • 0034650693 scopus 로고    scopus 로고
    • Transgenic expression of Ly-49A in thymocytes alters repertoire selection
    • Pauza M, Smith KM, Neal H, et al. Transgenic expression of Ly-49A in thymocytes alters repertoire selection. J Immunol 2000; 164:884-892.
    • (2000) J Immunol , vol.164 , pp. 884-892
    • Pauza, M.1    Smith, K.M.2    Neal, H.3
  • 46
    • 61349149901 scopus 로고    scopus 로고
    • Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
    • Palmer E, Naeher D. Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol 2009; 9:207-213.
    • (2009) Nat Rev Immunol , vol.9 , pp. 207-213
    • Palmer, E.1    Naeher, D.2
  • 47
    • 84912569473 scopus 로고    scopus 로고
    • Functional comparison of engineered T cells carrying a native TCR versus TCR-like antibody-based chimeric antigen receptors indicates affinity/avidity thresholds
    • Oren R, Hod-Marco M, Haus-Cohen M, et al. Functional comparison of engineered T cells carrying a native TCR versus TCR-like antibody-based chimeric antigen receptors indicates affinity/avidity thresholds. J Immunol 2014; 193:5733-5743.
    • J Immunol , vol.193
    • Oren, R.1    Hod-Marco, M.2    Haus-Cohen, M.3
  • 48
    • 78649744678 scopus 로고    scopus 로고
    • Off-the-shelf T-cell therapy
    • Cooper LJN. Off-the-shelf T-cell therapy. Blood 2010; 116:4741-4743.
    • (2010) Blood , vol.116 , pp. 4741-4743
    • Cooper, L.J.N.1
  • 50
    • 85047691367 scopus 로고    scopus 로고
    • Memory CD4 T cells do not induce graftversus- host disease
    • Anderson B, McNiff J, Yan J. Memory CD4 T cells do not induce graftversus- host disease. J Clin Investig 2003; 112:101-108.
    • (2003) J Clin Investig , vol.112 , pp. 101-108
    • Anderson, B.1    McNiff, J.2    Yan, J.3
  • 51
    • 0842263996 scopus 로고    scopus 로고
    • Transfer of allogeneic CD62L-memory T cells without graft-versus-host disease
    • Chen BJ, Cui X, Sempowski GD, et al. Transfer of allogeneic CD62L-memory T cells without graft-versus-host disease. Blood 2004; 103:1534-1541.
    • (2004) Blood , vol.103 , pp. 1534-1541
    • Chen, B.J.1    Cui, X.2    Sempowski, G.D.3
  • 52
    • 4944252715 scopus 로고    scopus 로고
    • CD62L-memory T cells are less responsive to alloantigen stimulation than CD62L naive T cells: Potential for adoptive immunotherapy and allodepletion
    • Foster A, Marangolo M, Sartor M. CD62L-memory T cells are less responsive to alloantigen stimulation than CD62L naive T cells: potential for adoptive immunotherapy and allodepletion. Blood 2004; 104:2403-2410.
    • (2004) Blood , vol.104 , pp. 2403-2410
    • Foster, A.1    Marangolo, M.2    Sartor, M.3
  • 53
    • 57949103408 scopus 로고    scopus 로고
    • Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy
    • Kondo M, Sakuta K, Noguchi A, Ariyoshi N. Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy. Cytotherapy 2008; 10:842-856.
    • (2008) Cytotherapy , vol.10 , pp. 842-856
    • Kondo, M.1    Sakuta, K.2    Noguchi, A.3    Ariyoshi, N.4
  • 54
    • 84875226632 scopus 로고    scopus 로고
    • Bispecific T-cells expressing polyclonal repertoire of endogenous gd T-cell receptors and introduced CD19-specific chimeric antigen receptor
    • Deniger DC, Switzer K, Mi T, et al. Bispecific T-cells expressing polyclonal repertoire of endogenous gd T-cell receptors and introduced CD19-specific chimeric antigen receptor. Mol Ther 2013; 21:638-647.
    • (2013) Mol Ther , vol.21 , pp. 638-647
    • Deniger, D.C.1    Switzer, K.2    Mi, T.3
  • 55
    • 84885612102 scopus 로고    scopus 로고
    • Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
    • Themeli M, Kloss CC, Ciriello G, et al. Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy. Nat Biotechnol 2013; 31:928-933.
    • (2013) Nat Biotechnol , vol.31 , pp. 928-933
    • Themeli, M.1    Kloss, C.C.2    Ciriello, G.3
  • 56
    • 84928697751 scopus 로고    scopus 로고
    • The emerging Protumor role of gd T lymphocytes: Implications for cancer immunotherapy
    • Rei M, Pennington DJ, Silva-Santos B. The emerging Protumor role of gd T lymphocytes: implications for cancer immunotherapy. Cancer Res 2015; 75:798-802.
    • (2015) Cancer Res , vol.75 , pp. 798-802
    • Rei, M.1    Pennington, D.J.2    Silva-Santos, B.3
  • 57
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L, Capanni M, Urbani E, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295:2097-2101.
    • (2002) Science , vol.295 , pp. 2097-2101
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3
  • 58
    • 84902682889 scopus 로고    scopus 로고
    • Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
    • Bachanova V, Cooley S, Defor TE, et al. Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood 2014; 123:3855-3863.
    • (2014) Blood , vol.123 , pp. 3855-3863
    • Bachanova, V.1    Cooley, S.2    Defor, T.E.3
  • 59
    • 84932195488 scopus 로고    scopus 로고
    • Natural killer cell therapy in children with relapsed leukemia
    • Rubnitz J, Inaba H, Kang G, et al. Natural killer cell therapy in children with relapsed leukemia. Pediatric Blood Cancer 2015; 62:1468-1472.
    • (2015) Pediatric Blood Cancer , vol.62 , pp. 1468-1472
    • Rubnitz, J.1    Inaba, H.2    Kang, G.3
  • 60
    • 84921805688 scopus 로고    scopus 로고
    • Acute GVHD in patients receiving IL- 15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation
    • Shah NN, Baird K, Delbrook CP, et al. Acute GVHD in patients receiving IL- 15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation. Blood 2015; 125:784-792.
    • (2015) Blood , vol.125 , pp. 784-792
    • Shah, N.N.1    Baird, K.2    Delbrook, C.P.3
  • 61
    • 84934281880 scopus 로고    scopus 로고
    • Chu Y, Hochberg J, Yahr A, et al., Targeting CD20 aggressive B-cell non-Hodgkin lymphoma by anti-CD20 CAR mRNA-modified expanded natural killer cells in vitro and in NSG mice
    • Chu Y, Hochberg J, Yahr A, et al. Targeting CD20 aggressive B-cell non-Hodgkin lymphoma by anti-CD20 CAR mRNA-modified expanded natural killer cells in vitro and in NSG mice. Cancer Immunol Res 2015; 3:333- 344.
    • (2015) Cancer Immunol Res , vol.3 , pp. 333-344
  • 62
    • 84908612560 scopus 로고    scopus 로고
    • Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy
    • Heczey A, Liu D, Tian G, et al. Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy. Blood 2014; 124:2824-2833.
    • (2014) Blood , vol.124 , pp. 2824-2833
    • Heczey, A.1    Liu, D.2    Tian, G.3
  • 63
    • 84929677695 scopus 로고    scopus 로고
    • NK cells modified with an EGFRvIII-specific chimeric antigen receptor to overexpress CXCR4 improves immunotherapy of CXCL12/SDF-1a-secreting glioblastoma
    • Müller N, Michen S, Tietze S, et al. NK cells modified with an EGFRvIII-specific chimeric antigen receptor to overexpress CXCR4 improves immunotherapy of CXCL12/SDF-1a-secreting glioblastoma. J Immunother 2015; 38:197- 210.
    • (2015) J Immunother , vol.38 , pp. 197-210
    • Müller, N.1    Michen, S.2    Tietze, S.3
  • 64
    • 84894325649 scopus 로고    scopus 로고
    • Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells
    • Jiang H, Zhang W, Shang P, et al. Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells. Mol Oncol 2014; 8:297-310.
    • (2014) Mol Oncol , vol.8 , pp. 297-310
    • Jiang, H.1    Zhang, W.2    Shang, P.3
  • 65
    • 84922257867 scopus 로고    scopus 로고
    • Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor
    • Schö nfeld K, Sahm C, Zhang C, et al. Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor. Mol Ther 2015; 23:330-338.
    • (2015) Mol Ther , vol.23 , pp. 330-338
    • Schönfeld, K.1    Sahm, C.2    Zhang, C.3
  • 66
    • 84925852082 scopus 로고    scopus 로고
    • DAP12-based activating chimeric antigen receptor for NK cell tumor immunotherapy
    • Töpfer K, Cartellieri M, Michen S, et al. DAP12-based activating chimeric antigen receptor for NK cell tumor immunotherapy. J Immunol 2015; 194:3201-3212.
    • (2015) J Immunol , vol.194 , pp. 3201-3212
    • Töpfer, P.K.1    Cartellieri, M.2    Michen, S.3
  • 67
    • 84862496486 scopus 로고    scopus 로고
    • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimericantigen- receptor and eliminate expression of endogenous TCR
    • Torikai H, Reik A, Liu PQ, et al. A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimericantigen- receptor and eliminate expression of endogenous TCR. Blood 2012; 119:5697-5706.
    • (2012) Blood , vol.119 , pp. 5697-5706
    • Torikai, H.1    Reik, A.2    Liu, P.Q.3
  • 68
    • 84902084418 scopus 로고    scopus 로고
    • TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer
    • Berdien B, Mock U, Atanackovic D, Fehse B. TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer. Gene Ther 2014; 21:539-548.
    • (2014) Gene Ther , vol.21 , pp. 539-548
    • Berdien, B.1    Mock, U.2    Atanackovic, D.3    Fehse, B.4
  • 69
    • 84942903938 scopus 로고    scopus 로고
    • Multiplex genome edited T-cell manufacturing platform for 'off-the-shelf' adoptive T-cell immunotherapies
    • Epub ahead of print
    • Poirot L, Philip B, Schiffer-Mannioui C, et al. Multiplex genome edited T-cell manufacturing platform for 'off-the-shelf' adoptive T-cell immunotherapies. Cancer Res 2015. [Epub ahead of print].
    • (2015) Cancer Res
    • Poirot, L.1    Philip, B.2    Schiffer-Mannioui, C.3
  • 70
    • 84922671463 scopus 로고    scopus 로고
    • Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9
    • Mandal PK, Ferreira LMR, Collins R, et al. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell 2014; 15:643-652.
    • (2014) Cell Stem Cell , vol.15 , pp. 643-652
    • Mandal, P.K.1    Ferreira, L.M.R.2    Collins, R.3
  • 71
    • 84886849781 scopus 로고    scopus 로고
    • Toward eliminating HLA class I expression to generate universal cells from allogeneic donors
    • Torikai H, Reik A, Soldner F, et al. Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. Blood 2013; 122:1341- 1350.
    • (2013) Blood , vol.122 , pp. 1341-1350
    • Torikai, H.1    Reik, A.2    Soldner, F.3
  • 72
    • 77953647938 scopus 로고    scopus 로고
    • The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex
    • Bridgeman JS, Hawkins RE, Bagley S, et al. The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex. J Immunol 2010; 184:6938-6949.
    • (2010) J Immunol , vol.184 , pp. 6938-6949
    • Bridgeman, J.S.1    Hawkins, R.E.2    Bagley, S.3
  • 73
    • 84891594672 scopus 로고    scopus 로고
    • CD3j-based chimeric antigen receptors mediate T cell activation via cis- And trans-signalling mechanisms: Implications for optimization of receptor structure for adoptive cell therapy
    • Bridgeman JS, Ladell K, Sheard VE, et al. CD3j-based chimeric antigen receptors mediate T cell activation via cis- And trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy. Clin Exp Immunol 2014; 175:258-267..
    • (2014) Clin Exp Immunol , vol.175 , pp. 258-267
    • Bridgeman, J.S.1    Ladell, K.2    Sheard, V.E.3
  • 74
    • 80455162464 scopus 로고    scopus 로고
    • Inducible apoptosis as a safety switch for adoptive cell therapy
    • Di Stasi A, Tey S-K, Dotti G, et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med 2011; 365:1673-1683.
    • (2011) N Engl J Med , vol.365 , pp. 1673-1683
    • Di Stasi, A.1    Tey, S.-K.2    Dotti, G.3
  • 75
    • 84902654151 scopus 로고    scopus 로고
    • Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene
    • Zhou X, Stasi ADi, Tey S, et al. Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene. Blood 2014; 123:3895-3906.
    • (2014) Blood , vol.123 , pp. 3895-3906
    • Zhou, X.1    Stasi, A.2    Tey, S.3
  • 76
    • 84888270638 scopus 로고    scopus 로고
    • CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
    • Casucci M, Nicolis di Robilant B, Falcone L, et al. CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma. Blood 2013; 122:3461-3472.
    • (2013) Blood , vol.122 , pp. 3461-3472
    • Casucci, M.1    Di Nicolis, R.B.2    Falcone, L.3


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