Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival

Transplant International

Volumn 17, Issue 7, 2004, Pages 351-361

  Cho, H R ^a,b   Kwon, B ^a,b   Yagita, H ^c   La, S ^a   Lee, E A ^a   Kim, J E ^a   Akiba, H ^c   Kim, J ^a   Suh, J H ^d   Vinay, D S ^e   Ju, S A ^a   Kim, B S ^a   Mittler, R S ^f   Okumura, K ^c   Kwon, B S ^a,e  

^a University of Ulsan   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Ulsan University College of Medicine   (South Korea)

^e LSU EYE CENTER   (United States)

^f EMORY UNIVERSITY   (United States)

Author keywords

Co stimulation; Rodent; T cells; Transplantation

Indexed keywords

ALLOANTIGEN; CD137 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4 1BBL; UNCLASSIFIED DRUG;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXIC T LYMPHOCYTE; DRUG SCREENING; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOPROPHYLAXIS; IN VIVO STUDY; LYMPH NODE; LYMPHATIC DRAINAGE; LYMPHOCYTIC INFILTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; PROTEIN INTERACTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VASCULITIS;

4-1BB LIGAND; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD137; CELL DIVISION; DENDRITIC CELLS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; ISOANTIGENS; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, MUTANT STRAINS; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4544354937     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2004.tb00454.x     Document Type: Article

References (43)

1. Vinay DS, Kwon BS. Role of 4-1BB in immune responses. Sem Immunol 1998; 10:481.
2. Kwon B, Moon CH, Kang S, Seo SK, Kwon BS. 4-1BB: still in the midst of darkness. Mol Cells 2000; 10:119.
3. Goodwin RG, Din WS, Davis-Smith T, et al. Molecular cloning a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol 1993; 23:2631.
4. Pollok KE, Kim YJ, Hurtado J, et al. 4-1BB T cell antigen binds to mature B cells and macrophages, and costimulates anti-μ-primed splenic B cells. Eur J Immunol 1994; 24:367.
5. - T lymphocytes by 4-1BB ligand. J Immunol 1997; 158:551.
6. Futagawa T, Akiba H, Kodama T, et al. Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol 2002; 14:275.
7. + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 1999; 186:47.
8. Melero I, Shufford WW, Newby SA, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecules eradicate established tumors. Nat Med 1997; 3:682.
9. Wilcox RA, Flies DB, Zhu G, et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest 2002; 109:651.
10. Diehl L, van Mierlo GJD, den Boer AT, et al. In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulation pathway. J Immunol 2002; 168:3755.
11. DeBenedette MA, Wen T, Bachmann MF, et al. Analysis of 4-1BB ligand-deficient mice and of mice lacking both 4-1BB and CD28 reveals a role for 4-1BB in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol 1999; 163:4833.
12. Tan JT, Whitmire JK, Ahmed R, Pearson TC, Larsen CP. 4-1BB ligand, a member of the TNF superfamily, is important for the generation of antiviral CD8 T cell responses. J Immunol 1999; 163:4859.
13. Tan JT, Whitmire JK, Murali-Krishna K, et al. 4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination. J Immunol 2000; 164:2320.
14. Kwon BS, Hurtado JC, Lee ZH, et al. Immune responses in 4-1BB (CD137)-deficient mice. J Immunol 2002; 168:5483.
15. Bertram EM, Lau P, Watts TH. Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J Immunol 2002; 168:3777.
16. Ye Z, Hellstrom I, Hayden-Ledbetter M, Dahlin A, Ledbetter JA, Hellstrom KE. Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB. Nat Med 2002; 8:343.
17. Gramaglia I, Cooper D, Miner KT, Kwon BS, Croft M. Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand. Eur J Immunol 2000; 30:392.
18. Cannons JL, Lau P, Ghumman B, et al. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J Immunol 2001; 167:1313.
19. Wen T, Bukczynski J, Watts TH. 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J Immunol 2002; 168:4897.
20. Maus MV, Thomas AK, Leonard DGB, et al. Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligand for the T-cell receptor, CD28 and 4-1BB. Nat Biotech 2002; 20:143.
21. Cooper D, Bansal-Pakala P, Croft M. 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity. Eur J Immunol 2002; 32:521.
22. Takahashi C, Mittler RS, Vella AT. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol 1999: 162:5037.
23. + T cell responses. Nat Immunol. 2002; 3:536.
24. L and Bfl-1. J Immunol 2002; 169:4882.
25. + T cells. Trends Immunol 2002; 23:378.
26. Kwon B, Kim B-S, Cho HR, Park J-E, Kwon BS. Involvement of tumor necrosis factor receptor superfamily (TN FRSF) members in the pathogenesis of inflammatory disease. Exp Mol Med 2003; 35:8.
27. Blazar BR, Kwon BS, Panoskaltsis-Mortari A, Kwak KB, Peschon JJ, Taylor PA. Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplantation recipients. J Immunol 2001; 166:3174.
28. Tan JT, Ha J, Cho HR, et al. Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses. Transplantation 2000; 70:175.
29. + T cell responses by administration of antig-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases. J Immunol 2001; 167:4981.
30. Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK. Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med 1999; 190:1535.
31. Sun Y, Lin X, Chen HM, et al. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J. Immunol. 2002; 168:1457.
32. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381:434.
33. Schuchin EJ, Langmuir PB, Palmer E, Sayegh MH, Wells AD, Turka LA. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J Immunol 2001; 166:973.
34. Catalina MD, Carroll MC, Arizpe H, Takashima A, Estess P, Siegelman MH. The route of antigen entry determines the requirement for L-selectin during immune responses. J Exp Med 1996; 184:2341.
35. Corry RJ, Winn HJ, Russel PS. Primary vascularized allografts of hearts in mice. Transplantation 1973; 16:343.
36. + T cells. Am J Transplant 2003; 3:543.
37. Denton MD, Magee CC, Sayegh MH. Immunosuppressive strategies in transplantation. Lancet 1999; 353:1083.
38. Waldman H. Transplantation tolerance - where do we stand? Nat Med 1999; 5:1245.
39. Wilcox RA, Chapoval AI, Gorski KS, et al. Cutting edge: Expression of functional CD137 receptor by dendritic cells. J Immunol 2002; 168:4262.
40. Seko Y, Takahashi N, Oshima H, et al. Expression of tumor necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, X40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxackievirus B3. J Pathol 2001; 195:593.
41. Seo SK, Park HY, Choi JH, et al. Blocking 4-1BB/4-1BB ligand interations prevents herpetic stromal keratitis. J Immunol. 2003; 171:576.
42. Sun Y, Chen HM, Subushi SK, et al. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 2002; 8:1405.
43. 1 mice. J Clin Invest 2003; 111:1505.