Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models

Journal of Immunology

Volumn 166, Issue 1, 2001, Pages 322-329

  Rothstein, D M ^a   Livak, M F A ^a   Kishimoto, K ^a   Ariyan, C ^a   Qian, H Y ^a   Fecteau, S ^a   Sho, M ^a   Deng, S ^a   Zheng, X X ^a   Sayegh, M H ^a   Basadonna, G P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD45RB ANTIGEN; CD8 ANTIGEN; CYTOKINE; GLYCOPROTEIN GP 39; GLYCOPROTEIN GP 39 MONOCLONAL ANTIBODY; LYMPHOCYTE ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MB23G2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTIC INFILTRATION; MALE; MONOCYTE; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SKIN ALLOGRAFT; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TREATMENT OUTCOME;

EID: 0035159495     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.1.322     Document Type: Article

References (64)

1. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
2. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
3. Models of T cell anergy: Is there a common molecular mechanism?
4. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
5. + T cell regulation during the induction phase of the response
6. Prevention and reversal of renal allograft rejection by antibody against CD45
7. Antibody mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy
8. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
9. CD28-DB7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
10. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
11. CD40-gp30 interactions play a critical role during allograft rejection
12. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
13. Long term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
14. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
15. + T cells play a critical role in costimulation blockade-resistant allograft rejection
16. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
17. On the preclinical results of anti-CD154 and islets
18. + T cells is antigen-specific and requires expression of target alloantigen on Ia- epidermal cells
19. + cells are essential for allorejection
20. Cells mediating allograft rejection
21. + T cells
22. Differential T cell costimulatory requirements in CD28-deficient mice
23. CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection
24. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
25. Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment
26. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction
27. + T cells
28. A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines
29. T cells in inflammatory bowel disease: Protective and pathogenic roles
30. Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein tyrosine phosphatase
31. Individual isoforms of the CD45 protein tyrosine phosphatase differentially regulate IL-2 secretion and activation signal pathways involving Vav in T cells
32. CD40-CD40Linteractions are essential for thymus-dependent humeral immunity. 11. Prolonged suppression of the humeral immune response by an antibody to the ligand for CD40, CD40L
33. Quantitative comparison of rapamycin and cyclosporine effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction
34. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue
35. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
36. The CD40 pathway in allograft rejection, acceptance and tolerance
37. The CD40 ligand, CD40L, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
38. Activation of human dendritic cells through CD40 cross-linking
39. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H
40. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction
41. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
42. Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1
43. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
44. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
45. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
46. + helper and a T-killer cell
47. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalitis
48. Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand Black x New Zealand White mice: Response correlates with absence of antiantibody response
49. -/- mice
50. The second domain of the CD45 transmembrane protein tyrosine phosphatase is critical for IL-2 secretion and for recruitment of substrates in vivo
51. Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways
52. Regulation of integrin-mediated T cell adhesion by the transmembrane protein tyrosine phosphatase CD45
53. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion
54. Positive and negative regulation of Srcfamily membrane kinases by CD45
55. IL-2 knockout recipient mice reject islet cell allografts
56. Blocking the CD28-B7 T cell costimulatory pathway induces long-term cardiac allograft acceptance in the absence of IL-4
57. Acute rejection of vascularized heart allografts in the absence of IFNγ
58. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
59. Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice
60. Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA-Fc treatment
61. On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses
62. The role of CD154-CD40 Versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
63. Adoptively transferable tolerance induced by CD45RB monoclonal antibody
64. Type 2 helper T cell cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients