메뉴 건너뛰기




Volumn 229, Issue 1, 2009, Pages 152-172

Molecular mechanism and function of CD40/CD40L engagement in the immune system

Author keywords

CD40; CD40L; Cellular immunity; Graft tolerance; Humoral immunity; TRAF proteins; Tumor immunity; Tumor necrosis family

Indexed keywords

ABATACEPT; ANTINEOPLASTIC AGENT; CD40 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CP 870893; CYCLOSPORIN A; HCD 122; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G ANTIBODY; RAPAMYCIN; SGN 40; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG;

EID: 65349149089     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2009.00782.x     Document Type: Review
Times cited : (1105)

References (230)
  • 1
    • 0033524482 scopus 로고    scopus 로고
    • A two-step, two-signal model for the primary activation of precursor helper T cells
    • Bretscher PA. A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci USA 1999 96 : 185 190.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 185-190
    • Bretscher, P.A.1
  • 2
    • 2542476167 scopus 로고    scopus 로고
    • CD40/CD154 interactions at the interface of tolerance and immunity
    • Quezada SA, et al. CD40/CD154 interactions at the interface of tolerance and immunity. Annu Rev Immunol 2004 22 : 307 328.
    • (2004) Annu Rev Immunol , vol.22 , pp. 307-328
    • Quezada, S.A.1
  • 3
    • 0035202768 scopus 로고    scopus 로고
    • The immunological synapse and CD28-CD80 interactions
    • Bromley SK, et al. The immunological synapse and CD28-CD80 interactions. Nat Immunol 2001 2 : 1159 1166.
    • (2001) Nat Immunol , vol.2 , pp. 1159-1166
    • Bromley, S.K.1
  • 4
    • 84934436838 scopus 로고    scopus 로고
    • Physiological roles and mechanisms of signaling by TRAF2 and TRAF5
    • Au PY, Yeh WC. Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. Adv Exp Med Biol 2007 597 : 32 47.
    • (2007) Adv Exp Med Biol , vol.597 , pp. 32-47
    • Au, P.Y.1    Yeh, W.C.2
  • 5
    • 0026778697 scopus 로고
    • Immunosuppression in vivo by a soluble form of the CTLA-4 T-cell activation molecule
    • Linsley PS, et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T-cell activation molecule. Science 1992 257 : 792 795.
    • (1992) Science , vol.257 , pp. 792-795
    • Linsley, P.S.1
  • 6
    • 0004535499 scopus 로고    scopus 로고
    • CD40-CD40 ligand
    • van Kooten C, et al. CD40-CD40 ligand. J Leukoc Biol 2000 67 : 2 17.
    • (2000) J Leukoc Biol , vol.67 , pp. 2-17
    • Van Kooten, C.1
  • 7
    • 0029156830 scopus 로고
    • Functional CD40 antigen on B cells, dendritic cells and fibroblasts
    • Banchereau J, et al. Functional CD40 antigen on B cells, dendritic cells and fibroblasts. Adv Exp Med Biol 1995 378 : 79 83.
    • (1995) Adv Exp Med Biol , vol.378 , pp. 79-83
    • Banchereau, J.1
  • 9
    • 0030744132 scopus 로고    scopus 로고
    • Functions of CD40 on B cells, dendritic cells and other cells
    • van Kooten C, Banchereau J. Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol 1997 9 : 330 337.
    • (1997) Curr Opin Immunol , vol.9 , pp. 330-337
    • Van Kooten, C.1    Banchereau, J.2
  • 11
    • 0028905489 scopus 로고
    • Recombinant soluble trimeric CD40 ligand is biologically active
    • Mazzei GJ, et al. Recombinant soluble trimeric CD40 ligand is biologically active. J Biol Chem 1995 270 : 7025 7028.
    • (1995) J Biol Chem , vol.270 , pp. 7025-7028
    • Mazzei, G.J.1
  • 12
    • 0028795582 scopus 로고
    • 2 A crystal structure of an extracellular fragment of human CD40 ligand
    • Karpusas M, et al. 2 A crystal structure of an extracellular fragment of human CD40 ligand. Structure 1995 3 : 1031 1039.
    • (1995) Structure , vol.3 , pp. 1031-1039
    • Karpusas, M.1
  • 13
    • 0030905897 scopus 로고    scopus 로고
    • A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction
    • Carbone E, et al. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J Environ Monit 1997 185 : 2053 2060.
    • (1997) J Environ Monit , vol.185 , pp. 2053-2060
    • Carbone, E.1
  • 14
    • 3042614161 scopus 로고    scopus 로고
    • The CD40/CD40L costimulatory pathway in inflammatory bowel disease
    • Danese S, Sans M, Fiocchi C. The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut 2004 53 : 1035 1043.
    • (2004) Gut , vol.53 , pp. 1035-1043
    • Danese, S.1    Sans, M.2    Fiocchi, C.3
  • 16
    • 0142027137 scopus 로고    scopus 로고
    • Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3
    • Saemann MD, et al. Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3. Am J Transplant 2003 3 : 1341 1349.
    • (2003) Am J Transplant , vol.3 , pp. 1341-1349
    • Saemann, M.D.1
  • 17
    • 0035993570 scopus 로고    scopus 로고
    • CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when Jak3 activity is inhibited
    • Saemann MD, Kelemen P, Zeyda M, Bohmig G, Staffler G, Zlabinger GJ. CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when Jak3 activity is inhibited. Transplant Proc 2002 34 : 1407 1408.
    • (2002) Transplant Proc , vol.34 , pp. 1407-1408
    • Saemann, M.D.1    Kelemen, P.2    Zeyda, M.3    Bohmig, G.4    Staffler, G.5    Zlabinger, G.J.6
  • 18
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-kappaB activation pathways and their role in innate and adaptive immunity
    • Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004 25 : 280 288.
    • (2004) Trends Immunol , vol.25 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 19
    • 0033520080 scopus 로고    scopus 로고
    • High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization
    • Pullen SS, et al. High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization. Biochemistry 1999 38 : 10168 10177.
    • (1999) Biochemistry , vol.38 , pp. 10168-10177
    • Pullen, S.S.1
  • 20
    • 0032566341 scopus 로고    scopus 로고
    • CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
    • Pullen SS, Miller HG, Everdeen DS, Dang TT, Crute JJ, Kehry MR. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. Biochemistry 1998 37 : 11836 11845.
    • (1998) Biochemistry , vol.37 , pp. 11836-11845
    • Pullen, S.S.1    Miller, H.G.2    Everdeen, D.S.3    Dang, T.T.4    Crute, J.J.5    Kehry, M.R.6
  • 21
    • 27644531924 scopus 로고    scopus 로고
    • TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells
    • Davies CC, Mak TW, Young LS, Eliopoulos AG. TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol Cell Biol 2005 25 : 9806 9819.
    • (2005) Mol Cell Biol , vol.25 , pp. 9806-9819
    • Davies, C.C.1    Mak, T.W.2    Young, L.S.3    Eliopoulos, A.G.4
  • 22
    • 0036146317 scopus 로고    scopus 로고
    • Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent
    • Manning E, Pullen SS, Souza DJ, Kehry M, Noelle RJ. Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent. Eur J Immunol 2002 32 : 39 49.
    • (2002) Eur J Immunol , vol.32 , pp. 39-49
    • Manning, E.1    Pullen, S.S.2    Souza, D.J.3    Kehry, M.4    Noelle, R.J.5
  • 23
    • 0242580942 scopus 로고    scopus 로고
    • CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding site
    • Lu LF, Cook WJ, Lin LL, Noelle RJ. CD40 signaling through a newly identified tumor necrosis factor receptor-associated factor 2 (TRAF2) binding site. J Biol Chem 2003 278 : 45414 45418.
    • (2003) J Biol Chem , vol.278 , pp. 45414-45418
    • Lu, L.F.1    Cook, W.J.2    Lin, L.L.3    Noelle, R.J.4
  • 24
    • 34347388618 scopus 로고    scopus 로고
    • The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation
    • Lu LF, et al. The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation. Blood 2007 110 : 193 200.
    • (2007) Blood , vol.110 , pp. 193-200
    • Lu, L.F.1
  • 26
    • 0034781511 scopus 로고    scopus 로고
    • Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154
    • Haswell LE, Glennie MJ, Al-Shamkhani A. Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154. Eur J Immunol 2001 31 : 3094 3100.
    • (2001) Eur J Immunol , vol.31 , pp. 3094-3100
    • Haswell, L.E.1    Glennie, M.J.2    Al-Shamkhani, A.3
  • 27
    • 0033553392 scopus 로고    scopus 로고
    • CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs
    • Pullen SS, Dang TT, Crute JJ, Kehry MR. CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs. J Biol Chem 1999 274 : 14246 14254.
    • (1999) J Biol Chem , vol.274 , pp. 14246-14254
    • Pullen, S.S.1    Dang, T.T.2    Crute, J.J.3    Kehry, M.R.4
  • 28
    • 0035129957 scopus 로고    scopus 로고
    • Functional activity of CD40 antibodies correlates to the position of binding relative to CD154
    • Barr TA, Heath AW. Functional activity of CD40 antibodies correlates to the position of binding relative to CD154. Immunology 2001 102 : 39 43.
    • (2001) Immunology , vol.102 , pp. 39-43
    • Barr, T.A.1    Heath, A.W.2
  • 29
    • 0033516570 scopus 로고    scopus 로고
    • The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase
    • Schwenzer R, et al. The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase. J Biol Chem 1999 274 : 19368 19374.
    • (1999) J Biol Chem , vol.274 , pp. 19368-19374
    • Schwenzer, R.1
  • 30
    • 0034326624 scopus 로고    scopus 로고
    • TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
    • Zapata JM, et al. TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol 2000 165 : 5084 5096.
    • (2000) J Immunol , vol.165 , pp. 5084-5096
    • Zapata, J.M.1
  • 31
    • 0037037545 scopus 로고    scopus 로고
    • Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling
    • Arron JR, Pewzner-Jung Y, Walsh MC, Kobayashi T, Choi Y. Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J Exp Med 2002 196 : 923 934.
    • (2002) J Exp Med , vol.196 , pp. 923-934
    • Arron, J.R.1    Pewzner-Jung, Y.2    Walsh, M.C.3    Kobayashi, T.4    Choi, Y.5
  • 32
    • 33645994488 scopus 로고    scopus 로고
    • Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling
    • Xie P, Hostager BS, Munroe ME, Moore CR, Bishop GA. Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling. J Immunol 2006 176 : 5388 5400.
    • (2006) J Immunol , vol.176 , pp. 5388-5400
    • Xie, P.1    Hostager, B.S.2    Munroe, M.E.3    Moore, C.R.4    Bishop, G.A.5
  • 33
    • 0242413228 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling
    • Hostager BS, Haxhinasto SA, Rowland SL, Bishop GA. Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 2003 278 : 45382 45390.
    • (2003) J Biol Chem , vol.278 , pp. 45382-45390
    • Hostager, B.S.1    Haxhinasto, S.A.2    Rowland, S.L.3    Bishop, G.A.4
  • 34
    • 0008206988 scopus 로고    scopus 로고
    • TRAF2 is essential for Jnk but not NF-kappaB activation and regulates lymphocyte proliferation and survival
    • Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzweig MC, Choi Y. TRAF2 is essential for Jnk but not NF-kappaB activation and regulates lymphocyte proliferation and survival. Immunity 1997 7 : 703 713.
    • (1997) Immunity , vol.7 , pp. 703-713
    • Lee, S.Y.1    Reichlin, A.2    Santana, A.3    Sokol, K.A.4    Nussenzweig, M.C.5    Choi, Y.6
  • 35
    • 0031463025 scopus 로고    scopus 로고
    • Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
    • Yeh WC, et al. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 1997 7 : 715 725.
    • (1997) Immunity , vol.7 , pp. 715-725
    • Yeh, W.C.1
  • 36
    • 33847002355 scopus 로고    scopus 로고
    • Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
    • Gallagher E, et al. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol 2007 8 : 57 63.
    • (2007) Nat Immunol , vol.8 , pp. 57-63
    • Gallagher, E.1
  • 37
    • 36148954336 scopus 로고    scopus 로고
    • IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    • Vince JE, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007 131 : 682 693.
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1
  • 38
    • 40249115896 scopus 로고    scopus 로고
    • TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    • Gardam S, Sierro F, Basten A, Mackay F, Brink R. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 2008 28 : 391 401.
    • (2008) Immunity , vol.28 , pp. 391-401
    • Gardam, S.1    Sierro, F.2    Basten, A.3    Mackay, F.4    Brink, R.5
  • 39
    • 56349164232 scopus 로고    scopus 로고
    • Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
    • Vallabhapurapu S, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 2008 9 : 1364 1370.
    • (2008) Nat Immunol , vol.9 , pp. 1364-1370
    • Vallabhapurapu, S.1
  • 40
    • 56349164239 scopus 로고    scopus 로고
    • Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    • Zarnegar BJ, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 2008 9 : 1371 1378.
    • (2008) Nat Immunol , vol.9 , pp. 1371-1378
    • Zarnegar, B.J.1
  • 41
    • 0037205442 scopus 로고    scopus 로고
    • Regulation of TRAF2 signaling by self-induced degradation
    • Brown KD, Hostager BS, Bishop GA. Regulation of TRAF2 signaling by self-induced degradation. J Biol Chem 2002 277 : 19433 19438.
    • (2002) J Biol Chem , vol.277 , pp. 19433-19438
    • Brown, K.D.1    Hostager, B.S.2    Bishop, G.A.3
  • 43
    • 1542313888 scopus 로고    scopus 로고
    • Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes
    • Xie P, Hostager BS, Bishop GA. Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes. J Exp Med 2004 199 : 661 671.
    • (2004) J Exp Med , vol.199 , pp. 661-671
    • Xie, P.1    Hostager, B.S.2    Bishop, G.A.3
  • 44
    • 0037020065 scopus 로고    scopus 로고
    • CD40-mediated activation of NF-kappa B in airway epithelial cells
    • Propst SM, Estell K, Schwiebert LM. CD40-mediated activation of NF-kappa B in airway epithelial cells. J Biol Chem 2002 277 : 37054 37063.
    • (2002) J Biol Chem , vol.277 , pp. 37054-37063
    • Propst, S.M.1    Estell, K.2    Schwiebert, L.M.3
  • 45
    • 0035179082 scopus 로고    scopus 로고
    • Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation
    • Urbich C, Mallat Z, Tedgui A, Clauss M, Zeiher AM, Dimmeler S. Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation. J Clin Invest 2001 108 : 1451 1458.
    • (2001) J Clin Invest , vol.108 , pp. 1451-1458
    • Urbich, C.1    Mallat, Z.2    Tedgui, A.3    Clauss, M.4    Zeiher, A.M.5    Dimmeler, S.6
  • 46
    • 14544286868 scopus 로고    scopus 로고
    • TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs
    • Hauer J, et al. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci USA 2005 102 : 2874 2879.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2874-2879
    • Hauer, J.1
  • 47
    • 0033578329 scopus 로고    scopus 로고
    • Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
    • Nakano H, et al. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proc Natl Acad Sci USA 1999 96 : 9803 9808.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9803-9808
    • Nakano, H.1
  • 49
    • 0035839450 scopus 로고    scopus 로고
    • A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation
    • Arron JR, et al. A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J Biol Chem 2001 276 : 30011 30017.
    • (2001) J Biol Chem , vol.276 , pp. 30011-30017
    • Arron, J.R.1
  • 50
    • 0347723953 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
    • Davies CC, Mason J, Wakelam MJ, Young LS, Eliopoulos AG. Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells. J Biol Chem 2004 279 : 1010 1019.
    • (2004) J Biol Chem , vol.279 , pp. 1010-1019
    • Davies, C.C.1    Mason, J.2    Wakelam, M.J.3    Young, L.S.4    Eliopoulos, A.G.5
  • 52
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone MH, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998 282 : 1318 1321.
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1
  • 53
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997 91 : 231 241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1
  • 54
    • 59849117647 scopus 로고    scopus 로고
    • Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B
    • Qiao G, et al. Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol 2007 179 : 4473 4479.
    • (2007) J Immunol , vol.179 , pp. 4473-4479
    • Qiao, G.1
  • 55
    • 0030917141 scopus 로고    scopus 로고
    • Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
    • Hanissian SH, Geha RS. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 1997 6 : 379 387.
    • (1997) Immunity , vol.6 , pp. 379-387
    • Hanissian, S.H.1    Geha, R.S.2
  • 56
    • 0033565949 scopus 로고    scopus 로고
    • Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells
    • Revy P, et al. Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells. J Immunol 1999 163 : 787 793.
    • (1999) J Immunol , vol.163 , pp. 787-793
    • Revy, P.1
  • 57
    • 0028097932 scopus 로고
    • Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene
    • Pine R, Canova A, Schindler C. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene. EMBO J 1994 13 : 158 167.
    • (1994) EMBO J , vol.13 , pp. 158-167
    • Pine, R.1    Canova, A.2    Schindler, C.3
  • 58
    • 0028201730 scopus 로고
    • The CD40 antigen and its ligand
    • Banchereau J, et al. The CD40 antigen and its ligand. Annu Rev Immunol 1994 12 : 881 922.
    • (1994) Annu Rev Immunol , vol.12 , pp. 881-922
    • Banchereau, J.1
  • 59
    • 0025891769 scopus 로고
    • CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells
    • Barrett TB, Shu G, Clark EA. CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells. J Immunol 1991 146 : 1722 1729.
    • (1991) J Immunol , vol.146 , pp. 1722-1729
    • Barrett, T.B.1    Shu, G.2    Clark, E.A.3
  • 60
    • 0010982635 scopus 로고
    • Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50
    • Clark EA, Ledbetter JA. Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc Natl Acad Sci USA 1986 83 : 4494 4498.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4494-4498
    • Clark, E.A.1    Ledbetter, J.A.2
  • 61
    • 0025650466 scopus 로고
    • CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
    • Jabara HH, Fu SM, Geha RS, Vercelli D. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J Exp Med 1990 172 : 1861 1864.
    • (1990) J Exp Med , vol.172 , pp. 1861-1864
    • Jabara, H.H.1    Fu, S.M.2    Geha, R.S.3    Vercelli, D.4
  • 62
    • 0028525547 scopus 로고
    • The expansive role of CD40 and its ligand, gp39, in immunity
    • Foy TM, Durie FH, Noelle RJ. The expansive role of CD40 and its ligand, gp39, in immunity. Semin Immunol 1994 6 : 259 266.
    • (1994) Semin Immunol , vol.6 , pp. 259-266
    • Foy, T.M.1    Durie, F.H.2    Noelle, R.J.3
  • 63
    • 0028298229 scopus 로고
    • gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory
    • Foy TM, Laman JD, Ledbetter JA, Aruffo A, Claassen E, Noelle RJ. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J Exp Med 1994 180 : 157 163.
    • (1994) J Exp Med , vol.180 , pp. 157-163
    • Foy, T.M.1    Laman, J.D.2    Ledbetter, J.A.3    Aruffo, A.4    Claassen, E.5    Noelle, R.J.6
  • 64
    • 0027493906 scopus 로고
    • In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39
    • Foy TM, Shepherd DM, Durie FH, Aruffo A, Ledbetter JA, Noelle RJ. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J Exp Med 1993 178 : 1567 1575.
    • (1993) J Exp Med , vol.178 , pp. 1567-1575
    • Foy, T.M.1    Shepherd, D.M.2    Durie, F.H.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 65
    • 1842631032 scopus 로고    scopus 로고
    • T-cell-B-cell cooperation
    • Mitchison NA. T-cell-B-cell cooperation. Nat Rev Immunol 2004 4 : 308 312.
    • (2004) Nat Rev Immunol , vol.4 , pp. 308-312
    • Mitchison, N.A.1
  • 66
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia A. Antigen-specific interaction between T and B cells. Nature 1985 314 : 537 539.
    • (1985) Nature , vol.314 , pp. 537-539
    • Lanzavecchia, A.1
  • 67
    • 0021209335 scopus 로고
    • Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors
    • Rock KL, Benacerraf B, Abbas AK. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med 1984 160 : 1102 1113.
    • (1984) J Exp Med , vol.160 , pp. 1102-1113
    • Rock, K.L.1    Benacerraf, B.2    Abbas, A.K.3
  • 68
    • 0024340990 scopus 로고
    • Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains
    • Loughnan MS, Nossal GJ. Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains. Nature 1989 340 : 76 79.
    • (1989) Nature , vol.340 , pp. 76-79
    • Loughnan, M.S.1    Nossal, G.J.2
  • 69
    • 0023388394 scopus 로고
    • T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells
    • Loughnan MS, Takatsu K, Harada N, Nossal GJ. T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells. Proc Natl Acad Sci USA 1987 84 : 5399 5403.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5399-5403
    • Loughnan, M.S.1    Takatsu, K.2    Harada, N.3    Nossal, G.J.4
  • 70
    • 0021680253 scopus 로고
    • Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor
    • Noelle R, Krammer PH, Ohara J, Uhr JW, Vitetta ES. Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor. Proc Natl Acad Sci USA 1984 81 : 6149 6153.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 6149-6153
    • Noelle, R.1    Krammer, P.H.2    Ohara, J.3    Uhr, J.W.4    Vitetta, E.S.5
  • 71
    • 0021821215 scopus 로고
    • B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth
    • Oliver K, Noelle RJ, Uhr JW, Krammer PH, Vitetta ES. B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth. Proc Natl Acad Sci USA 1985 82 : 2465 2467.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 2465-2467
    • Oliver, K.1    Noelle, R.J.2    Uhr, J.W.3    Krammer, P.H.4    Vitetta, E.S.5
  • 72
    • 0024415578 scopus 로고
    • Cognate interactions between helper T cells and B cells. II. Dissection of cognate help by using a class II-restricted, antigen-specific, IL-2-dependent helper T cell clone
    • Bartlett WC, Michael A, McCann J, Yuan D, Claassen E, Noelle RJ. Cognate interactions between helper T cells and B cells. II. Dissection of cognate help by using a class II-restricted, antigen-specific, IL-2-dependent helper T cell clone. J Immunol 1989 143 : 1745 1754.
    • (1989) J Immunol , vol.143 , pp. 1745-1754
    • Bartlett, W.C.1    Michael, A.2    McCann, J.3    Yuan, D.4    Claassen, E.5    Noelle, R.J.6
  • 73
    • 0025668704 scopus 로고
    • Cognate interactions between helper T cells and B cells. IV. Requirements for the expression of effector phase activity by helper T cells
    • Bartlett WC, McCann J, Shepherd DM, Roy M, Noelle RJ. Cognate interactions between helper T cells and B cells. IV. Requirements for the expression of effector phase activity by helper T cells. J Immunol 1990 145 : 3956 3962.
    • (1990) J Immunol , vol.145 , pp. 3956-3962
    • Bartlett, W.C.1    McCann, J.2    Shepherd, D.M.3    Roy, M.4    Noelle, R.J.5
  • 74
    • 0023706256 scopus 로고
    • Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells
    • Brian AA. Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells. Proc Natl Acad Sci USA 1988 85 : 564 568.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 564-568
    • Brian, A.A.1
  • 75
    • 0025176086 scopus 로고
    • Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines
    • Hodgkin PD, Yamashita LC, Coffman RL, Kehry MR. Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines. J Immunol 1990 145 : 2025 2034.
    • (1990) J Immunol , vol.145 , pp. 2025-2034
    • Hodgkin, P.D.1    Yamashita, L.C.2    Coffman, R.L.3    Kehry, M.R.4
  • 76
    • 0026772133 scopus 로고
    • A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
    • Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 1992 89 : 6550 6554.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6550-6554
    • Noelle, R.J.1    Roy, M.2    Shepherd, D.M.3    Stamenkovic, I.4    Ledbetter, J.A.5    Aruffo, A.6
  • 77
    • 0026528181 scopus 로고
    • Molecular and biological characterization of a murine ligand for CD40
    • Armitage RJ, et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992 357 : 80 82.
    • (1992) Nature , vol.357 , pp. 80-82
    • Armitage, R.J.1
  • 78
    • 27744576801 scopus 로고    scopus 로고
    • Cell surface recycling of internalized antigen permits dendritic cell priming of B cells
    • Bergtold A, Desai DD, Gavhane A, Clynes R. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 2005 23 : 503 514.
    • (2005) Immunity , vol.23 , pp. 503-514
    • Bergtold, A.1    Desai, D.D.2    Gavhane, A.3    Clynes, R.4
  • 79
    • 34247149876 scopus 로고    scopus 로고
    • The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles
    • Pape KA, Catron DM, Itano AA, Jenkins MK. The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 2007 26 : 491 502.
    • (2007) Immunity , vol.26 , pp. 491-502
    • Pape, K.A.1    Catron, D.M.2    Itano, A.A.3    Jenkins, M.K.4
  • 80
    • 0032145432 scopus 로고    scopus 로고
    • Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response
    • Wykes M, Pombo A, Jenkins C, MacPherson GG. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J Immunol 1998 161 : 1313 1319.
    • (1998) J Immunol , vol.161 , pp. 1313-1319
    • Wykes, M.1    Pombo, A.2    Jenkins, C.3    MacPherson, G.G.4
  • 81
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
    • Jacob J, Kassir R, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med 1991 173 : 1165 1175.
    • (1991) J Exp Med , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 82
    • 0026670190 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
    • Jacob J, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J Exp Med 1992 176 : 679 687.
    • (1992) J Exp Med , vol.176 , pp. 679-687
    • Jacob, J.1    Kelsoe, G.2
  • 84
    • 0027373275 scopus 로고
    • In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions
    • Van den Eertwegh AJ, et al. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J Exp Med 1993 178 : 1555 1565.
    • (1993) J Exp Med , vol.178 , pp. 1555-1565
    • Van Den Eertwegh, A.J.1
  • 86
    • 0028486131 scopus 로고
    • Mice deficient for the CD40 ligand
    • Xu J, et al. Mice deficient for the CD40 ligand. Immunity 1994 1 : 423 431.
    • (1994) Immunity , vol.1 , pp. 423-431
    • Xu, J.1
  • 87
    • 34247583988 scopus 로고    scopus 로고
    • Affinity of antigen encounter and other early B-cell signals determine B-cell fate
    • Benson MJ, Erickson LD, Gleeson MW, Noelle RJ. Affinity of antigen encounter and other early B-cell signals determine B-cell fate. Curr Opin Immunol 2007 19 : 275 280.
    • (2007) Curr Opin Immunol , vol.19 , pp. 275-280
    • Benson, M.J.1    Erickson, L.D.2    Gleeson, M.W.3    Noelle, R.J.4
  • 88
    • 33751574420 scopus 로고    scopus 로고
    • Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor
    • O'Connor BP, et al. Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor. J Immunol 2006 177 : 7723 7732.
    • (2006) J Immunol , vol.177 , pp. 7723-7732
    • O'Connor, B.P.1
  • 89
    • 33645856486 scopus 로고    scopus 로고
    • Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
    • Paus D, Phan TG, Chan TD, Gardam S, Basten A, Brink R. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J Exp Med 2006 203 : 1081 1091.
    • (2006) J Exp Med , vol.203 , pp. 1081-1091
    • Paus, D.1    Phan, T.G.2    Chan, T.D.3    Gardam, S.4    Basten, A.5    Brink, R.6
  • 90
    • 33750502877 scopus 로고    scopus 로고
    • High affinity germinal center B cells are actively selected into the plasma cell compartment
    • Phan TG, et al. High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med 2006 203 : 2419 2424.
    • (2006) J Exp Med , vol.203 , pp. 2419-2424
    • Phan, T.G.1
  • 91
    • 0036196782 scopus 로고    scopus 로고
    • Short-circuiting long-lived humoral immunity by the heightened engagement of CD40
    • Erickson LD, et al. Short-circuiting long-lived humoral immunity by the heightened engagement of CD40. J Clin Invest 2002 109 : 613 620.
    • (2002) J Clin Invest , vol.109 , pp. 613-620
    • Erickson, L.D.1
  • 92
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B-cell follicles, and support immunoglobulin production
    • Breitfeld D, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B-cell follicles, and support immunoglobulin production. J Exp Med 2000 192 : 1545 1552.
    • (2000) J Exp Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1
  • 93
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (TFH) cells in normal and dysregulated immune responses
    • King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 2008 26 : 741 766.
    • (2008) Annu Rev Immunol , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 94
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000 192 : 1553 1562.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 95
    • 0032701695 scopus 로고    scopus 로고
    • In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
    • Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 1999 190 : 1123 1134.
    • (1999) J Exp Med , vol.190 , pp. 1123-1134
    • Ansel, K.M.1    McHeyzer-Williams, L.J.2    Ngo, V.N.3    McHeyzer-Williams, M.G.4    Cyster, J.G.5
  • 96
    • 0034691531 scopus 로고    scopus 로고
    • A chemokine-driven positive feedback loop organizes lymphoid follicles
    • Ansel KM, et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 2000 406 : 309 314.
    • (2000) Nature , vol.406 , pp. 309-314
    • Ansel, K.M.1
  • 97
    • 0034678345 scopus 로고    scopus 로고
    • Developmental switches in chemokine response profiles during B cell differentiation and maturation
    • Bowman EP, et al. Developmental switches in chemokine response profiles during B cell differentiation and maturation. J Exp Med 2000 191 : 1303 1318.
    • (2000) J Exp Med , vol.191 , pp. 1303-1318
    • Bowman, E.P.1
  • 98
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 1996 87 : 1037 1047.
    • (1996) Cell , vol.87 , pp. 1037-1047
    • Forster, R.1    Mattis, A.E.2    Kremmer, E.3    Wolf, E.4    Brem, G.5    Lipp, M.6
  • 99
    • 0032545987 scopus 로고    scopus 로고
    • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
    • Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 1998 391 : 799 803.
    • (1998) Nature , vol.391 , pp. 799-803
    • Gunn, M.D.1    Ngo, V.N.2    Ansel, K.M.3    Ekland, E.H.4    Cyster, J.G.5    Williams, L.T.6
  • 100
    • 0032536373 scopus 로고    scopus 로고
    • B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    • Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 1998 187 : 655 660.
    • (1998) J Exp Med , vol.187 , pp. 655-660
    • Legler, D.F.1    Loetscher, M.2    Roos, R.S.3    Clark-Lewis, I.4    Baggiolini, M.5    Moser, B.6
  • 101
    • 0026060520 scopus 로고
    • Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication
    • Rogerson B, Hackett J Jr., Peters A, Haasch D, Storb U. Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication. EMBO J 1991 10 : 4331 4341.
    • (1991) EMBO J , vol.10 , pp. 4331-4341
    • Rogerson, B.1    Hackett Jr., J.2    Peters, A.3    Haasch, D.4    Storb, U.5
  • 102
    • 4644219817 scopus 로고    scopus 로고
    • Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
    • Allen CD, et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol 2004 5 : 943 952.
    • (2004) Nat Immunol , vol.5 , pp. 943-952
    • Allen, C.D.1
  • 103
    • 33846635838 scopus 로고    scopus 로고
    • Imaging of germinal center selection events during affinity maturation
    • Allen CD, Okada T, Tang HL, Cyster JG. Imaging of germinal center selection events during affinity maturation. Science 2007 315 : 528 531.
    • (2007) Science , vol.315 , pp. 528-531
    • Allen, C.D.1    Okada, T.2    Tang, H.L.3    Cyster, J.G.4
  • 104
    • 0031035199 scopus 로고    scopus 로고
    • Follicular dendritic cells specifically express the long CR2/CD21 isoform
    • Liu YJ, et al. Follicular dendritic cells specifically express the long CR2/CD21 isoform. J Exp Med 1997 185 : 165 170.
    • (1997) J Exp Med , vol.185 , pp. 165-170
    • Liu, Y.J.1
  • 105
    • 0034596892 scopus 로고    scopus 로고
    • Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells
    • Hannum LG, Haberman AM, Anderson SM, Shlomchik MJ. Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells. J Exp Med 2000 192 : 931 942.
    • (2000) J Exp Med , vol.192 , pp. 931-942
    • Hannum, L.G.1    Haberman, A.M.2    Anderson, S.M.3    Shlomchik, M.J.4
  • 106
    • 0029870531 scopus 로고    scopus 로고
    • Centrocytes rapidly adopt a memory B cell phenotype on co-culture with autologous germinal centre T cell-enriched preparations
    • Casamayor-Palleja M, Feuillard J, Ball J, Drew M, MacLennan IC. Centrocytes rapidly adopt a memory B cell phenotype on co-culture with autologous germinal centre T cell-enriched preparations. Int Immunol 1996 8 : 737 744.
    • (1996) Int Immunol , vol.8 , pp. 737-744
    • Casamayor-Palleja, M.1    Feuillard, J.2    Ball, J.3    Drew, M.4    MacLennan, I.C.5
  • 107
    • 0027161266 scopus 로고
    • Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bc1-2 induction
    • Holder MJ, et al. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bc1-2 induction. Eur J Immunol 1993 23 : 2368 2371.
    • (1993) Eur J Immunol , vol.23 , pp. 2368-2371
    • Holder, M.J.1
  • 109
    • 0035910760 scopus 로고    scopus 로고
    • FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis
    • Hennino A, Berard M, Krammer PH, Defrance T. FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis. J Exp Med 2001 193 : 447 458.
    • (2001) J Exp Med , vol.193 , pp. 447-458
    • Hennino, A.1    Berard, M.2    Krammer, P.H.3    Defrance, T.4
  • 110
    • 0029819465 scopus 로고    scopus 로고
    • Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center
    • Tuscano JM, Druey KM, Riva A, Pena J, Thompson CB, Kehrl JH. Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center. Blood 1996 88 : 1359 1364.
    • (1996) Blood , vol.88 , pp. 1359-1364
    • Tuscano, J.M.1    Druey, K.M.2    Riva, A.3    Pena, J.4    Thompson, C.B.5    Kehrl, J.H.6
  • 111
    • 0032536872 scopus 로고    scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection
    • Takahashi Y, Dutta PR, Cerasoli DM, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J Exp Med 1998 187 : 885 895.
    • (1998) J Exp Med , vol.187 , pp. 885-895
    • Takahashi, Y.1    Dutta, P.R.2    Cerasoli, D.M.3    Kelsoe, G.4
  • 112
    • 0036098501 scopus 로고    scopus 로고
    • The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells
    • Ahonen C, et al. The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat Immunol 2002 3 : 451 456.
    • (2002) Nat Immunol , vol.3 , pp. 451-456
    • Ahonen, C.1
  • 113
    • 18644383624 scopus 로고    scopus 로고
    • The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching
    • Jabara H, et al. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity 2002 17 : 265 276.
    • (2002) Immunity , vol.17 , pp. 265-276
    • Jabara, H.1
  • 114
    • 0036195954 scopus 로고    scopus 로고
    • Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals
    • Yasui T, et al. Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Int Immunol 2002 14 : 319 329.
    • (2002) Int Immunol , vol.14 , pp. 319-329
    • Yasui, T.1
  • 116
    • 0033574060 scopus 로고    scopus 로고
    • Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation
    • Lee HH, Dempsey PW, Parks TP, Zhu X, Baltimore D, Cheng G. Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation. Proc Natl Acad Sci USA 1999 96 : 1421 1426.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1421-1426
    • Lee, H.H.1    Dempsey, P.W.2    Parks, T.P.3    Zhu, X.4    Baltimore, D.5    Cheng, G.6
  • 117
    • 0028525777 scopus 로고
    • The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency
    • Ochs HD, Hollenbaugh D, Aruffo A. The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency. Semin Immunol 1994 6 : 337 341.
    • (1994) Semin Immunol , vol.6 , pp. 337-341
    • Ochs, H.D.1    Hollenbaugh, D.2    Aruffo, A.3
  • 118
    • 42149125598 scopus 로고    scopus 로고
    • Outside inside signalling in CD40-mediated B-cell activation
    • D'Orlando O, et al. Outside inside signalling in CD40-mediated B-cell activation. J Biol Regul Homeost Agents 2007 21 : 49 62.
    • (2007) J Biol Regul Homeost Agents , vol.21 , pp. 49-62
    • D'Orlando, O.1
  • 119
    • 65349134526 scopus 로고    scopus 로고
    • The role of positive costimulatory molecules in transplantation and tolerance
    • Agarwal A, Newell KA. The role of positive costimulatory molecules in transplantation and tolerance. Curr Opin Organ Transplant 2008 13 : 366 372.
    • (2008) Curr Opin Organ Transplant , vol.13 , pp. 366-372
    • Agarwal, A.1    Newell, K.A.2
  • 120
    • 33947223664 scopus 로고    scopus 로고
    • Prospect of targeting the CD40 pathway for cancer therapy
    • Vonderheide RH. Prospect of targeting the CD40 pathway for cancer therapy. Clin Cancer Res 2007 13 : 1083 1088.
    • (2007) Clin Cancer Res , vol.13 , pp. 1083-1088
    • Vonderheide, R.H.1
  • 121
    • 12344336336 scopus 로고    scopus 로고
    • The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway
    • Toubi E, Shoenfeld Y. The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway. Autoimmunity 2004 37 : 457 464.
    • (2004) Autoimmunity , vol.37 , pp. 457-464
    • Toubi, E.1    Shoenfeld, Y.2
  • 122
    • 0026738641 scopus 로고
    • Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA-4lg
    • Lenschow DJ, et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA-4lg. Science 1992 257 : 789 792.
    • (1992) Science , vol.257 , pp. 789-792
    • Lenschow, D.J.1
  • 123
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley PS, Greene JL, Brady W, Bajorath J, Ledbetter JA, Peach R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994 1 : 793 801.
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 124
    • 0028135078 scopus 로고
    • CTLA-4Ig prolongs allograft survival while suppressing cell-mediated immunity
    • Baliga P, et al. CTLA-4Ig prolongs allograft survival while suppressing cell-mediated immunity. Transplantation 1994 58 : 1082 1090.
    • (1994) Transplantation , vol.58 , pp. 1082-1090
    • Baliga, P.1
  • 125
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • Ranheim EA, Kipps TJ. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 1993 177 : 925 935.
    • (1993) J Exp Med , vol.177 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 126
    • 0028985959 scopus 로고
    • Tumor necrosis factor-alpha facilitates induction of CD80 (B7-1) and CD54 on human B cells by activated T cells: complex regulation by IL-4, IL-10, and CD40L
    • Ranheim EA, Kipps TJ. Tumor necrosis factor-alpha facilitates induction of CD80 (B7-1) and CD54 on human B cells by activated T cells: complex regulation by IL-4, IL-10, and CD40L. Cell Immunol 1995 161 : 226 235.
    • (1995) Cell Immunol , vol.161 , pp. 226-235
    • Ranheim, E.A.1    Kipps, T.J.2
  • 127
    • 0034662277 scopus 로고    scopus 로고
    • + T cells can trigger allograft rejection
    • + T cells can trigger allograft rejection. J Immunol 2000 165 : 1111 1118.
    • (2000) J Immunol , vol.165 , pp. 1111-1118
    • Jones, N.D.1
  • 128
    • 0034784475 scopus 로고    scopus 로고
    • Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice
    • Lehnert AM, et al. Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice. Transpl Immunol 2001 9 : 51 56.
    • (2001) Transpl Immunol , vol.9 , pp. 51-56
    • Lehnert, A.M.1
  • 130
    • 0345164351 scopus 로고    scopus 로고
    • Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment
    • Li Y, Zheng XX, Li XC, Zand MS, Strom TB. Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment. Transplantation 1998 66 : 1387 1388.
    • (1998) Transplantation , vol.66 , pp. 1387-1388
    • Li, Y.1    Zheng, X.X.2    Li, X.C.3    Zand, M.S.4    Strom, T.B.5
  • 132
    • 30844436377 scopus 로고    scopus 로고
    • Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance
    • Chalermskulrat W, et al. Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance. Thorax 2006 61 : 61 67.
    • (2006) Thorax , vol.61 , pp. 61-67
    • Chalermskulrat, W.1
  • 133
    • 0030046808 scopus 로고    scopus 로고
    • CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway
    • Larsen CP, et al. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996 61 : 4 9.
    • (1996) Transplantation , vol.61 , pp. 4-9
    • Larsen, C.P.1
  • 134
    • 0028882526 scopus 로고
    • Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
    • Parker DC, et al. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci USA 1995 92 : 9560 9564.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9560-9564
    • Parker, D.C.1
  • 135
    • 0042441104 scopus 로고    scopus 로고
    • Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation
    • Quezada SA, et al. Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood 2003 102 : 1920 1926.
    • (2003) Blood , vol.102 , pp. 1920-1926
    • Quezada, S.A.1
  • 136
    • 0021330371 scopus 로고
    • Comparison of immune responsiveness in mice after single or multiple donor-specific transfusions
    • Wood ML, Gottschalk R, Monaco AP. Comparison of immune responsiveness in mice after single or multiple donor-specific transfusions. J Immunol 1984 132 : 651 655.
    • (1984) J Immunol , vol.132 , pp. 651-655
    • Wood, M.L.1    Gottschalk, R.2    Monaco, A.P.3
  • 137
    • 0033018250 scopus 로고    scopus 로고
    • Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts
    • Zheng XX, et al. Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts. Transplant Proc 1999 31 : 627 628.
    • (1999) Transplant Proc , vol.31 , pp. 627-628
    • Zheng, X.X.1
  • 139
    • 0037152164 scopus 로고    scopus 로고
    • Immune tolerance after delivery of dying cells to dendritic cells in situ
    • Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K, Steinman RM. Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med 2002 196 : 1091 1097.
    • (2002) J Exp Med , vol.196 , pp. 1091-1097
    • Liu, K.1    Iyoda, T.2    Saternus, M.3    Kimura, Y.4    Inaba, K.5    Steinman, R.M.6
  • 140
    • 0033104692 scopus 로고    scopus 로고
    • Tolerance to antigen-presenting cell-depleted islet allografts is CD4 T cell dependent
    • Coulombe M, Yang H, Wolf LA, Gill RG. Tolerance to antigen-presenting cell-depleted islet allografts is CD4 T cell dependent. J Immunol 1999 162 : 2503 2510.
    • (1999) J Immunol , vol.162 , pp. 2503-2510
    • Coulombe, M.1    Yang, H.2    Wolf, L.A.3    Gill, R.G.4
  • 141
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 142
    • 0037219716 scopus 로고    scopus 로고
    • Distinctive maturation of in vitro versus in vivo anti-CD40 mAb-matured dendritic cells in mice
    • Frleta D, et al. Distinctive maturation of in vitro versus in vivo anti-CD40 mAb-matured dendritic cells in mice. J Immunother 2003 26 : 72 84.
    • (2003) J Immunother , vol.26 , pp. 72-84
    • Frleta, D.1
  • 143
    • 0036199656 scopus 로고    scopus 로고
    • Dendritic cell development and survival require distinct NF-kappaB subunits
    • Ouaaz F, Arron J, Zheng Y, Choi Y, Beg AA. Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity 2002 16 : 257 270.
    • (2002) Immunity , vol.16 , pp. 257-270
    • Ouaaz, F.1    Arron, J.2    Zheng, Y.3    Choi, Y.4    Beg, A.A.5
  • 144
    • 0031439265 scopus 로고    scopus 로고
    • TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
    • Wong BR, et al. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 1997 186 : 2075 2080.
    • (1997) J Exp Med , vol.186 , pp. 2075-2080
    • Wong, B.R.1
  • 145
    • 0344613988 scopus 로고    scopus 로고
    • Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
    • Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999 5 : 1298 1302.
    • (1999) Nat Med , vol.5 , pp. 1298-1302
    • Li, Y.1    Li, X.C.2    Zheng, X.X.3    Wells, A.D.4    Turka, L.A.5    Strom, T.B.6
  • 146
    • 0035865066 scopus 로고    scopus 로고
    • Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death
    • Wekerle T, et al. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol 2001 166 : 2311 2316.
    • (2001) J Immunol , vol.166 , pp. 2311-2316
    • Wekerle, T.1
  • 147
    • 0345476290 scopus 로고    scopus 로고
    • Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
    • Wells AD, et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 1999 5 : 1303 1307.
    • (1999) Nat Med , vol.5 , pp. 1303-1307
    • Wells, A.D.1
  • 148
    • 0141713778 scopus 로고    scopus 로고
    • Antibody-induced transplantation tolerance: the role of dominant regulation
    • Graca L, Le Moine A, Cobbold SP, Waldmann H. Antibody-induced transplantation tolerance: the role of dominant regulation. Immunol Res 2003 28 : 181 191.
    • (2003) Immunol Res , vol.28 , pp. 181-191
    • Graca, L.1    Le Moine, A.2    Cobbold, S.P.3    Waldmann, H.4
  • 149
    • 4544263376 scopus 로고    scopus 로고
    • + cell subsets and different mechanisms
    • + cell subsets and different mechanisms. Transplantation 2004 78 : 660 667.
    • (2004) Transplantation , vol.78 , pp. 660-667
    • Banuelos, S.J.1
  • 150
    • 40049105939 scopus 로고    scopus 로고
    • Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients
    • Guillonneau C, et al. Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. J Immunol 2007 179 : 8164 8171.
    • (2007) J Immunol , vol.179 , pp. 8164-8171
    • Guillonneau, C.1
  • 151
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 2007 204 : 1765 1774.
    • (2007) J Exp Med , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 153
    • 0032103285 scopus 로고    scopus 로고
    • Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA-4
    • Markees TG, et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA-4. J Clin Invest 1998 101 : 2446 2455.
    • (1998) J Clin Invest , vol.101 , pp. 2446-2455
    • Markees, T.G.1
  • 154
    • 38949173232 scopus 로고    scopus 로고
    • Costimulation blockade in autoimmunity and transplantation
    • quiz 7-8.
    • Vincenti F. Costimulation blockade in autoimmunity and transplantation. J Allergy Clin Immunol 2008 121 : 299 306 quiz 7-8.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 299-306
    • Vincenti, F.1
  • 155
    • 34247881846 scopus 로고    scopus 로고
    • Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model
    • Mai G, del Rio ML, Tian J, Ramirez P, Buhler L, Rodriguez-Barbosa JI. Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model. Xenotransplantation 2007 14 : 243 248.
    • (2007) Xenotransplantation , vol.14 , pp. 243-248
    • Mai, G.1    Del Rio, M.L.2    Tian, J.3    Ramirez, P.4    Buhler, L.5    Rodriguez-Barbosa, J.I.6
  • 156
    • 34547631576 scopus 로고    scopus 로고
    • PD-1-PD-L1 pathway is involved in suppressing alloreactivity of heart infiltrating T cells during murine GVHD across minor histocompatibility antigen barriers
    • Schilbach K, et al. PD-1-PD-L1 pathway is involved in suppressing alloreactivity of heart infiltrating T cells during murine GVHD across minor histocompatibility antigen barriers. Transplantation 2007 84 : 214 222.
    • (2007) Transplantation , vol.84 , pp. 214-222
    • Schilbach, K.1
  • 157
    • 31144460031 scopus 로고    scopus 로고
    • Critical, but conditional, role of OX40 in memory T cell-mediated rejection
    • Vu MD, Clarkson MR, Yagita H, Turka LA, Sayegh MH, Li XC. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol 2006 176 : 1394 1401.
    • (2006) J Immunol , vol.176 , pp. 1394-1401
    • Vu, M.D.1    Clarkson, M.R.2    Yagita, H.3    Turka, L.A.4    Sayegh, M.H.5    Li, X.C.6
  • 158
    • 0347363460 scopus 로고    scopus 로고
    • The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice
    • Berney T, et al. The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice. Transplantation 2003 76 : 1669 1674.
    • (2003) Transplantation , vol.76 , pp. 1669-1674
    • Berney, T.1
  • 159
    • 26644446441 scopus 로고    scopus 로고
    • Prolonged survival of microencapsulated neonatal porcine islets in mice treated with a combination of anti-CD154 and anti-LFA-1 monoclonal antibodies
    • Kobayashi T, Harb G, Rayat GR. Prolonged survival of microencapsulated neonatal porcine islets in mice treated with a combination of anti-CD154 and anti-LFA-1 monoclonal antibodies. Transplantation 2005 80 : 821 827.
    • (2005) Transplantation , vol.80 , pp. 821-827
    • Kobayashi, T.1    Harb, G.2    Rayat, G.R.3
  • 161
    • 0036839226 scopus 로고    scopus 로고
    • CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways
    • Nicolls MR, Coulombe M, Beilke J, Gelhaus HC, Gill RG. CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways. J Immunol 2002 169 : 4831 4839.
    • (2002) J Immunol , vol.169 , pp. 4831-4839
    • Nicolls, M.R.1    Coulombe, M.2    Beilke, J.3    Gelhaus, H.C.4    Gill, R.G.5
  • 162
    • 12744274512 scopus 로고    scopus 로고
    • Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB
    • Rayat GR, Gill RG. Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB. Diabetes 2005 54 : 443 451.
    • (2005) Diabetes , vol.54 , pp. 443-451
    • Rayat, G.R.1    Gill, R.G.2
  • 163
    • 0141557857 scopus 로고    scopus 로고
    • Targeting LFA-1 synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection
    • Wang Y, Gao D, Lunsford KE, Frankel WL, Bumgardner GL. Targeting LFA-1 synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection. Am J Transplant 2003 3 : 1251 1258.
    • (2003) Am J Transplant , vol.3 , pp. 1251-1258
    • Wang, Y.1    Gao, D.2    Lunsford, K.E.3    Frankel, W.L.4    Bumgardner, G.L.5
  • 164
    • 33845898897 scopus 로고    scopus 로고
    • IL-2 pathway blocking in combination with anti-CD154 synergistically establishes mixed macrochimerism with limited dose of bone marrow cells and prolongs skin graft survival in mice
    • Lee JH, Ha J, Kim SH, Kim SJ. IL-2 pathway blocking in combination with anti-CD154 synergistically establishes mixed macrochimerism with limited dose of bone marrow cells and prolongs skin graft survival in mice. J Korean Med Sci 2006 21 : 1005 1011.
    • (2006) J Korean Med Sci , vol.21 , pp. 1005-1011
    • Lee, J.H.1    Ha, J.2    Kim, S.H.3    Kim, S.J.4
  • 165
    • 37049022155 scopus 로고    scopus 로고
    • Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantation
    • Pan H, et al. Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantation. Transplant Proc 2007 39 : 3452 3454.
    • (2007) Transplant Proc , vol.39 , pp. 3452-3454
    • Pan, H.1
  • 166
    • 33751191378 scopus 로고    scopus 로고
    • Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade
    • Wang Y, Dai H, Liu Z, Cheng X, Tellides G, Dai Z. Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade. Am J Transplant 2006 6 : 2851 2860.
    • (2006) Am J Transplant , vol.6 , pp. 2851-2860
    • Wang, Y.1    Dai, H.2    Liu, Z.3    Cheng, X.4    Tellides, G.5    Dai, Z.6
  • 167
    • 0141886132 scopus 로고    scopus 로고
    • Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms
    • Demirci G, Strom TB, Li XC. Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms. J Immunol 2003 171 : 3878 3885.
    • (2003) J Immunol , vol.171 , pp. 3878-3885
    • Demirci, G.1    Strom, T.B.2    Li, X.C.3
  • 168
    • 0033831056 scopus 로고    scopus 로고
    • A rare find - cells that improve bone marrow transplantation
    • Li XC, Strom TB. A rare find - cells that improve bone marrow transplantation. Nat Med 2000 6 : 866 867.
    • (2000) Nat Med , vol.6 , pp. 866-867
    • Li, X.C.1    Strom, T.B.2
  • 169
    • 0033379266 scopus 로고    scopus 로고
    • Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection
    • Trambley J, et al. Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest 1999 104 : 1715 1722.
    • (1999) J Clin Invest , vol.104 , pp. 1715-1722
    • Trambley, J.1
  • 170
    • 0034671978 scopus 로고    scopus 로고
    • Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts
    • Williams MA, et al. Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts. J Immunol 2000 165 : 6849 6857.
    • (2000) J Immunol , vol.165 , pp. 6849-6857
    • Williams, M.A.1
  • 171
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005 6 : 338 344.
    • (2005) Nat Immunol , vol.6 , pp. 338-344
    • Von Boehmer, H.1
  • 172
    • 0036852170 scopus 로고    scopus 로고
    • CTLA-4-Ig regulates tryptophan catabolism in vivo
    • Grohmann U, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002 3 : 1097 1101.
    • (2002) Nat Immunol , vol.3 , pp. 1097-1101
    • Grohmann, U.1
  • 173
    • 1642485023 scopus 로고    scopus 로고
    • Critical role of OX40 in CD28 and CD154-independent rejection
    • Demirci G, et al. Critical role of OX40 in CD28 and CD154-independent rejection. J Immunol 2004 172 : 1691 1698.
    • (2004) J Immunol , vol.172 , pp. 1691-1698
    • Demirci, G.1
  • 174
    • 34948883517 scopus 로고    scopus 로고
    • + Tregs
    • + Tregs. Blood 2007 110 : 2501 2510.
    • (2007) Blood , vol.110 , pp. 2501-2510
    • Vu, M.D.1
  • 177
    • 28344436464 scopus 로고    scopus 로고
    • Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth
    • Baxendale AJ, et al. Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth. Oncogene 2005 24 : 7913 7923.
    • (2005) Oncogene , vol.24 , pp. 7913-7923
    • Baxendale, A.J.1
  • 178
    • 33947260196 scopus 로고    scopus 로고
    • In vitro characterization and pre-clinical pharmacokinetics of CP-870,893, a human anti-CD40 agonist antibody
    • (Abstract).
    • Bedian V, et al. In vitro characterization and pre-clinical pharmacokinetics of CP-870,893, a human anti-CD40 agonist antibody. J Clin Oncol 2006 24 : 2539. (Abstract).
    • (2006) J Clin Oncol , vol.24
    • Bedian, V.1
  • 179
    • 33947688348 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of a fully human, antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12), in patients with relapsed and refractory multiple myeloma
    • (Abstract).
    • Bensinger W, et al. A phase 1 dose escalation study of a fully human, antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12), in patients with relapsed and refractory multiple myeloma. Blood 2006 108 : 3590. (Abstract).
    • (2006) Blood , vol.108
    • Bensinger, W.1
  • 180
    • 33847724350 scopus 로고    scopus 로고
    • + T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy
    • + T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nat Med 2007 13 : 354 360.
    • (2007) Nat Med , vol.13 , pp. 354-360
    • Berner, V.1
  • 181
    • 65349169910 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12) in patients with relapsed and refractory chronic lymphocytic leukemia
    • (Abstract).
    • Byrd JC, et al. Pharmacokinetics and pharmacodynamics from a first-in-human phase 1 dose escalation study with antagonist anti-CD40 antibody, HCD 122 (formerly CHIR-12.12) in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2006 108 : 2837. (Abstract).
    • (2006) Blood , vol.108
    • Byrd, J.C.1
  • 182
    • 18244397199 scopus 로고    scopus 로고
    • CD40 is expressed and functional on neuronal cells
    • Tan J, et al. CD40 is expressed and functional on neuronal cells. EMBO J 2002 21 : 643 652.
    • (2002) EMBO J , vol.21 , pp. 643-652
    • Tan, J.1
  • 183
    • 0024361435 scopus 로고
    • Identification of a human epithelial cell surface protein sharing an epitope with the C3d/Epstein-Barr virus receptor molecule of B lymphocytes
    • Young LS, Dawson CW, Brown KW, Rickinson AB. Identification of a human epithelial cell surface protein sharing an epitope with the C3d/Epstein-Barr virus receptor molecule of B lymphocytes. Int J Cancer 1989 43 : 786 794.
    • (1989) Int J Cancer , vol.43 , pp. 786-794
    • Young, L.S.1    Dawson, C.W.2    Brown, K.W.3    Rickinson, A.B.4
  • 185
    • 0033120913 scopus 로고    scopus 로고
    • CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma
    • Altenburg A, Baldus SE, Smola H, Pfister H, Hess S. CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma. J Immunol 1999 162 : 4140 4147.
    • (1999) J Immunol , vol.162 , pp. 4140-4147
    • Altenburg, A.1    Baldus, S.E.2    Smola, H.3    Pfister, H.4    Hess, S.5
  • 186
    • 0036215615 scopus 로고    scopus 로고
    • CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion
    • Gallagher NJ, Eliopoulos AG, Agathangelo A, Oates J, Crocker J, Young LS. CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion. Mol Pathol 2002 55 : 110 120.
    • (2002) Mol Pathol , vol.55 , pp. 110-120
    • Gallagher, N.J.1    Eliopoulos, A.G.2    Agathangelo, A.3    Oates, J.4    Crocker, J.5    Young, L.S.6
  • 187
    • 0028783879 scopus 로고
    • Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma. Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells
    • Agathanggelou A, Niedobitek G, Chen R, Nicholls J, Yin W, Young LS. Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma. Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells. Am J Pathol 1995 147 : 1152 1160.
    • (1995) Am J Pathol , vol.147 , pp. 1152-1160
    • Agathanggelou, A.1    Niedobitek, G.2    Chen, R.3    Nicholls, J.4    Yin, W.5    Young, L.S.6
  • 188
    • 0032032524 scopus 로고    scopus 로고
    • Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells
    • Kato K, Cantwell MJ, Sharma S, Kipps TJ. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. J Clin Invest 1998 101 : 1133 1141.
    • (1998) J Clin Invest , vol.101 , pp. 1133-1141
    • Kato, K.1    Cantwell, M.J.2    Sharma, S.3    Kipps, T.J.4
  • 189
    • 0029986786 scopus 로고    scopus 로고
    • CD11a-CD18 and CD102 interactions mediate human myeloma cell growth arrest induced by CD40 stimulation
    • Pellat-Deceunynck C, Amiot M, Robillard N, Wijdenes J, Bataille R. CD11a-CD18 and CD102 interactions mediate human myeloma cell growth arrest induced by CD40 stimulation. Cancer Res 1996 56 : 1909 1916.
    • (1996) Cancer Res , vol.56 , pp. 1909-1916
    • Pellat-Deceunynck, C.1    Amiot, M.2    Robillard, N.3    Wijdenes, J.4    Bataille, R.5
  • 190
    • 12944283267 scopus 로고    scopus 로고
    • CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines
    • Teoh G, et al. CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines. Blood 2000 95 : 1039 1046.
    • (2000) Blood , vol.95 , pp. 1039-1046
    • Teoh, G.1
  • 191
    • 0036841640 scopus 로고    scopus 로고
    • CD40L induces proliferation, self-renewal, rescue from apoptosis, and production of cytokines by CD40-expressing AML blasts
    • Aldinucci D, et al. CD40L induces proliferation, self-renewal, rescue from apoptosis, and production of cytokines by CD40-expressing AML blasts. Exp Hematol 2002 30 : 1283 1292.
    • (2002) Exp Hematol , vol.30 , pp. 1283-1292
    • Aldinucci, D.1
  • 192
    • 0028979118 scopus 로고
    • The role of Bcl-XL in CD40-mediated rescue from anti-mu-induced apoptosis in WEHI-231 B lymphoma cells
    • Choi MS, Boise LH, Gottschalk AR, Quintans J, Thompson CB, Klaus GG. The role of Bcl-XL in CD40-mediated rescue from anti-mu-induced apoptosis in WEHI-231 B lymphoma cells. Eur J Immunol 1995 25 : 1352 1357.
    • (1995) Eur J Immunol , vol.25 , pp. 1352-1357
    • Choi, M.S.1    Boise, L.H.2    Gottschalk, A.R.3    Quintans, J.4    Thompson, C.B.5    Klaus, G.G.6
  • 193
    • 0029073035 scopus 로고
    • Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis
    • Sarma V, et al. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem 1995 270 : 12343 12346.
    • (1995) J Biol Chem , vol.270 , pp. 12343-12346
    • Sarma, V.1
  • 194
    • 0030579195 scopus 로고    scopus 로고
    • Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis
    • Zhang X, et al. Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis. Cell Immunol 1996 173 : 149 154.
    • (1996) Cell Immunol , vol.173 , pp. 149-154
    • Zhang, X.1
  • 195
    • 0033529416 scopus 로고    scopus 로고
    • NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes
    • Lee HH, Dadgostar H, Cheng Q, Shu J, Cheng G. NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc Natl Acad Sci USA 1999 96 : 9136 9141.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9136-9141
    • Lee, H.H.1    Dadgostar, H.2    Cheng, Q.3    Shu, J.4    Cheng, G.5
  • 196
    • 0036173059 scopus 로고    scopus 로고
    • A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas
    • Pham LV, et al. A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas. Immunity 2002 16 : 37 50.
    • (2002) Immunity , vol.16 , pp. 37-50
    • Pham, L.V.1
  • 197
    • 0036566251 scopus 로고    scopus 로고
    • Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells
    • Challa A, et al. Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells. Blood 2002 99 : 3411 3418.
    • (2002) Blood , vol.99 , pp. 3411-3418
    • Challa, A.1
  • 198
    • 0034651739 scopus 로고    scopus 로고
    • Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells
    • Furman RR, Asgary Z, Mascarenhas JO, Liou HC, Schattner EJ. Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. J Immunol 2000 164 : 2200 2206.
    • (2000) J Immunol , vol.164 , pp. 2200-2206
    • Furman, R.R.1    Asgary, Z.2    Mascarenhas, J.O.3    Liou, H.C.4    Schattner, E.J.5
  • 199
    • 0028265454 scopus 로고
    • Inhibition of human B-cell lymphoma growth by CD40 stimulation
    • Funakoshi S, et al. Inhibition of human B-cell lymphoma growth by CD40 stimulation. Blood 1994 83 : 2787 2794.
    • (1994) Blood , vol.83 , pp. 2787-2794
    • Funakoshi, S.1
  • 200
    • 0031788449 scopus 로고    scopus 로고
    • CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis
    • Wingett DG, Vestal RE, Forcier K, Hadjokas N, Nielson CP. CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis. Breast Cancer Res Treat 1998 50 : 27 36.
    • (1998) Breast Cancer Res Treat , vol.50 , pp. 27-36
    • Wingett, D.G.1    Vestal, R.E.2    Forcier, K.3    Hadjokas, N.4    Nielson, C.P.5
  • 201
    • 0033912082 scopus 로고    scopus 로고
    • CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
    • Eliopoulos AG, et al. CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol Cell Biol 2000 20 : 5503 5515.
    • (2000) Mol Cell Biol , vol.20 , pp. 5503-5515
    • Eliopoulos, A.G.1
  • 202
    • 0030067795 scopus 로고    scopus 로고
    • A novel function of CD40: induction of cell death in transformed cells
    • Hess S, Engelmann H. A novel function of CD40: induction of cell death in transformed cells. J Environ Monit 1996 183 : 159 167.
    • (1996) J Environ Monit , vol.183 , pp. 159-167
    • Hess, S.1    Engelmann, H.2
  • 203
    • 10544246075 scopus 로고    scopus 로고
    • CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr virus-encoded LMP1: involvement of TRAF3 as a common mediator
    • Eliopoulos AG, et al. CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr virus-encoded LMP1: involvement of TRAF3 as a common mediator. Oncogene 1996 13 : 2243 2254.
    • (1996) Oncogene , vol.13 , pp. 2243-2254
    • Eliopoulos, A.G.1
  • 204
    • 0033135236 scopus 로고
    • Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand
    • Hirano A, et al. Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand. Blood 1991 93 : 2999 3007.
    • (1991) Blood , vol.93 , pp. 2999-3007
    • Hirano, A.1
  • 205
    • 0034900413 scopus 로고    scopus 로고
    • Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer
    • Tong AW, et al. Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer. Clin Cancer Res 2001 7 : 691 703.
    • (2001) Clin Cancer Res , vol.7 , pp. 691-703
    • Tong, A.W.1
  • 206
    • 0037277480 scopus 로고    scopus 로고
    • Prospects for CD40-directed experimental therapy of human cancer
    • Tong AW, Stone MJ. Prospects for CD40-directed experimental therapy of human cancer. Cancer Gene Ther 2003 10 : 1 13.
    • (2003) Cancer Gene Ther , vol.10 , pp. 1-13
    • Tong, A.W.1    Stone, M.J.2
  • 207
    • 0030797455 scopus 로고    scopus 로고
    • Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154
    • Mackey MF, et al. Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154. Cancer Res 1997 57 : 2569 2574.
    • (1997) Cancer Res , vol.57 , pp. 2569-2574
    • Mackey, M.F.1
  • 208
    • 0032896709 scopus 로고    scopus 로고
    • CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
    • French RR, Chan HT, Tutt AL, Glennie MJ. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat Med 1999 5 : 548 553.
    • (1999) Nat Med , vol.5 , pp. 548-553
    • French, R.R.1    Chan, H.T.2    Tutt, A.L.3    Glennie, M.J.4
  • 209
    • 0032984496 scopus 로고    scopus 로고
    • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
    • Diehl L, et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med 1999 5 : 774 779.
    • (1999) Nat Med , vol.5 , pp. 774-779
    • Diehl, L.1
  • 210
    • 0032984347 scopus 로고    scopus 로고
    • + T-cell tolerance to T-cell priming through in vivo ligation of CD40
    • + T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nat Med 1999 5 : 780 787.
    • (1999) Nat Med , vol.5 , pp. 780-787
    • Sotomayor, E.M.1
  • 211
    • 0037117542 scopus 로고    scopus 로고
    • CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity
    • van Mierlo GJ, et al. CD40 stimulation leads to effective therapy of CD40(-) tumors through induction of strong systemic cytotoxic T lymphocyte immunity. Proc Natl Acad Sci USA 2002 99 : 5561 5566.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5561-5566
    • Van Mierlo, G.J.1
  • 212
    • 0035845543 scopus 로고    scopus 로고
    • CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination
    • Kedl RM, Jordan M, Potter T, Kappler J, Marrack P, Dow S. CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination. Proc Natl Acad Sci USA 2001 98 : 10811 10816.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10811-10816
    • Kedl, R.M.1    Jordan, M.2    Potter, T.3    Kappler, J.4    Marrack, P.5    Dow, S.6
  • 213
    • 42449147062 scopus 로고    scopus 로고
    • Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines
    • Ahonen CL, et al. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood 2008 111 : 3116 3125.
    • (2008) Blood , vol.111 , pp. 3116-3125
    • Ahonen, C.L.1
  • 214
    • 0030685703 scopus 로고    scopus 로고
    • Antitumor responses induced by transgenic expression of CD40 ligand
    • Grossmann ME, Brown MP, Brenner MK. Antitumor responses induced by transgenic expression of CD40 ligand. Hum Gene Ther 1997 8 : 1935 1943.
    • (1997) Hum Gene Ther , vol.8 , pp. 1935-1943
    • Grossmann, M.E.1    Brown, M.P.2    Brenner, M.K.3
  • 215
    • 0035893748 scopus 로고    scopus 로고
    • CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunization with melanoma antigen gene-modified dendritic cells
    • Ribas A, et al. CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunization with melanoma antigen gene-modified dendritic cells. Cancer Res 2001 61 : 8787 8793.
    • (2001) Cancer Res , vol.61 , pp. 8787-8793
    • Ribas, A.1
  • 216
    • 0033587141 scopus 로고    scopus 로고
    • Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells
    • Kikuchi T, Crystal RG. Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells. Hum Gene Ther 1999 10 : 1375 1387.
    • (1999) Hum Gene Ther , vol.10 , pp. 1375-1387
    • Kikuchi, T.1    Crystal, R.G.2
  • 217
    • 0034234661 scopus 로고    scopus 로고
    • Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors
    • Kikuchi T, Moore MA, Crystal RG. Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors. Blood 2000 96 : 91 99.
    • (2000) Blood , vol.96 , pp. 91-99
    • Kikuchi, T.1    Moore, M.A.2    Crystal, R.G.3
  • 218
    • 33947419944 scopus 로고    scopus 로고
    • A humanized antibody against CD40 (SGN-CD40) is well tolerated and active in non-Hodgkin's lymphoma (NHL): results of a phase 1 study
    • (Abstract).
    • Forero-Torres A, et al. A humanized antibody against CD40 (SGN-CD40) is well tolerated and active in non-Hodgkin's lymphoma (NHL): results of a phase 1 study. J Clin Oncol 2006 24 : 7534. (Abstract).
    • (2006) J Clin Oncol , vol.24
    • Forero-Torres, A.1
  • 219
    • 0035397985 scopus 로고    scopus 로고
    • Phase I study of recombinant human CD40 ligand in cancer patients
    • Vonderheide RH, et al. Phase I study of recombinant human CD40 ligand in cancer patients. J Clin Oncol 2001 19 : 3280 3287.
    • (2001) J Clin Oncol , vol.19 , pp. 3280-3287
    • Vonderheide, R.H.1
  • 220
    • 0035575845 scopus 로고    scopus 로고
    • CD40 ligand therapy of lymphoma patients
    • Younes A. CD40 ligand therapy of lymphoma patients. J Clin Oncol 2001 19 : 4351 4353.
    • (2001) J Clin Oncol , vol.19 , pp. 4351-4353
    • Younes, A.1
  • 222
    • 0034469757 scopus 로고    scopus 로고
    • Immunogenetic therapy for B-cell malignancies
    • Kipps TJ, Chu P, Wierda WG. Immunogenetic therapy for B-cell malignancies. Semin Oncol 2000 27 : 104 109.
    • (2000) Semin Oncol , vol.27 , pp. 104-109
    • Kipps, T.J.1    Chu, P.2    Wierda, W.G.3
  • 223
    • 0034995643 scopus 로고    scopus 로고
    • A pilot study of combined immunotherapy with autologous adoptive tumour-specific T-cell transfer, vaccination with CD40-activated malignant B cells and interleukin 2
    • Schultze JL, Anderson KC, Gilleece MH, Gribben JG, Nadler LM. A pilot study of combined immunotherapy with autologous adoptive tumour-specific T-cell transfer, vaccination with CD40-activated malignant B cells and interleukin 2. Br J Haematol 2001 113 : 455 460.
    • (2001) Br J Haematol , vol.113 , pp. 455-460
    • Schultze, J.L.1    Anderson, K.C.2    Gilleece, M.H.3    Gribben, J.G.4    Nadler, L.M.5
  • 224
    • 33947506186 scopus 로고    scopus 로고
    • Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
    • Vonderheide RH, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol 2007 25 : 876 883.
    • (2007) J Clin Oncol , vol.25 , pp. 876-883
    • Vonderheide, R.H.1
  • 225
    • 33646250289 scopus 로고    scopus 로고
    • A phase I humanized anti-CD40 monoclonal antibody (SGN-40) in patients with multiple myeloma
    • (Abstract).
    • Hussein MA, et al. A phase I humanized anti-CD40 monoclonal antibody (SGN-40) in patients with multiple myeloma. Blood 2005 106 : 3576 (Abstract).
    • (2005) Blood , vol.106 , pp. 3576
    • Hussein, M.A.1
  • 226
    • 32644436462 scopus 로고    scopus 로고
    • Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation
    • Rousseau RF, et al. Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation. Blood 2006 107 : 1332 1341.
    • (2006) Blood , vol.107 , pp. 1332-1341
    • Rousseau, R.F.1
  • 227
    • 0034546367 scopus 로고    scopus 로고
    • Role for CD40-CD40 ligand interactions in the immune response to solid tumours
    • Alexandroff AB, et al. Role for CD40-CD40 ligand interactions in the immune response to solid tumours. Mol Immunol 2000 37 : 515 526.
    • (2000) Mol Immunol , vol.37 , pp. 515-526
    • Alexandroff, A.B.1
  • 228
    • 50949133383 scopus 로고    scopus 로고
    • The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells
    • Luqman M, et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood 2008 112 : 711 720.
    • (2008) Blood , vol.112 , pp. 711-720
    • Luqman, M.1
  • 229
    • 0042591416 scopus 로고    scopus 로고
    • Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors
    • Nowak AK, Robinson BW, Lake RA. Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors. Cancer Res 2003 63 : 4490 4496.
    • (2003) Cancer Res , vol.63 , pp. 4490-4496
    • Nowak, A.K.1    Robinson, B.W.2    Lake, R.A.3
  • 230
    • 0041737455 scopus 로고    scopus 로고
    • Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma
    • Honeychurch J, Glennie MJ, Johnson PW, Illidge TM. Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma. Blood 2003 102 : 1449 1457.
    • (2003) Blood , vol.102 , pp. 1449-1457
    • Honeychurch, J.1    Glennie, M.J.2    Johnson, P.W.3    Illidge, T.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.