Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients

Journal of Immunology

Volumn 186, Issue 5, 2011, Pages 2739-2749

  Yi, Tangsheng ^a   Li, Xiaofan ^a,b   Yao, Sheng ^c   Wang, Lin ^a   Chen, Yuhong ^a,d   Zhao, Dongchang ^a   Johnston, Heather F ^a   Young, James S ^a   Liu, Hongjun ^a   Todorov, Ivan ^a   Forman, Stephen J ^a   Chen, Lieping ^c   Zeng, Defu ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b FUJIAN MEDICAL UNIVERSITY   (China)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G2A ANTIBODY;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; GLOMERULONEPHRITIS; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; IMMUNE RESPONSE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; REGULATORY T LYMPHOCYTE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD80; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; GRAFT VS HOST DISEASE; IMMUNITY, INNATE; INTERFERON-GAMMA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; PEPTIDES; T-LYMPHOCYTES, REGULATORY;

EID: 79952760899     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002939     Document Type: Article

References (52)

1. Welniak, L. A., B. R. Blazar, and W. J. Murphy. 2007. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu. Rev. Immunol. 25: 139-170.
2. Ferrara, J. L., and J. H. Antin. 2004. The pathophysiology of graft-vs.-host disease. In Thomas' Hematopoietic Cell Transplantation. K. G. Blume, S. J. Forman, and F. R. Appelbaum, eds. Blackwell Publishing, Malden, MA, p. 353-368.
3. Albert, M. H., Y. Liu, C. Anasetti, and X. Z. Yu. 2005. Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation. Eur. J. Immunol. 35: 2598-2607.
4. Chen, X., S. Vodanovic-Jankovic, B. Johnson, M. Keller, R. Komorowski, and W. R. Drobyski. 2007. Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. Blood 110: 3804-3813.
5. + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9: 1144-1150.
6. + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196: 389-399.
7. Nguyen, V. H., R. Zeiser, D. L. Dasilva, D. S. Chang, A. Beilhack, C. H. Contag, and R. S. Negrin. 2007. In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood 109: 2649-2656.
8. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193: 1311-1318.
9. + regulatory T cells ameliorate ongoing chronic graft-versus-host disease. Blood 112: 2129-2138.
10. + T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations. Blood 107: 2993-3001.
11. Teshima, T., R. Ordemann, P. Reddy, S. Gagin, C. Liu, K. R. Cooke, and J. L. Ferrara. 2002. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat. Med. 8: 575-581.
12. Shlomchik, W. D., M. S. Couzens, C. B. Tang, J. McNiff, M. E. Robert, J. Liu, M. J. Shlomchik, and S. G. Emerson. 1999. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 285: 412-415.
13. Bluestone, J. A., and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3: 253-257.
14. + regulatory T cells via a TGF-β and retinoic acid-dependent mechanism. J. Exp. Med. 204: 1757-1764.
15. Mucida, D., Y. Park, G. Kim, O. Turovskaya, I. Scott, M. Kronenberg, and H. Cheroutre. 2007. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256-260. (Pubitemid 47076203)
16. Sun, C. M., J. A. Hall, R. B. Blank, N. Bouladoux, M. Oukka, J. R. Mora, and Y. Belkaid. 2007. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204: 1775-1785.
17. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
18. - cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10. J. Immunol. 172: 5213-5221.
19. Wong, J., D. Mathis, and C. Benoist. 2007. TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J. Exp. Med. 204: 2039-2045.
20. Francisco, L. M., V. H. Salinas, K. E. Brown, V. K. Vanguri, G. J. Freeman, V. K. Kuchroo, and A. H. Sharpe. 2009. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. Exp. Med. 206: 3015-3029.
21. Blazar, B. R., B. M. Carreno, A. Panoskaltsis-Mortari, L. Carter, Y. Iwai, H. Yagita, H. Nishimura, and P. A. Taylor. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-γ-dependent mechanism. J. Immunol. 171: 1272-1277.
22. Yi, T., D. Zhao, C. L. Lin, C. Zhang, Y. Chen, I. Todorov, T. LeBon, F. Kandeel, S. Forman, and D. Zeng. 2008. Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood 112: 2101-2110.
23. Asavaroengchai, W., H. Wang, S. Wang, L. Wang, R. Bronson, M. Sykes, and Y. G. Yang. 2007. An essential role for IFN-γ in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. Biol. Blood Marrow Transplant. 13: 46-55.
24. Yi, T., Y. Chen, L. Wang, G. Du, D. Huang, D. Zhao, H. Johnston, J. Young, I. Todorov, D. T. Umetsu, L. Chen, Y. Iwakura, F. Kandeel, S. Forman, and D. Zeng. 2009. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 114: 3101-3112.
25. Chen, L. 2004. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol. 4: 336-347.
26. Dong, H., G. Zhu, K. Tamada, and L. Chen. 1999. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5: 1365-1369.
27. Butte, M. J., M. E. Keir, T. B. Phamduy, A. H. Sharpe, and G. J. Freeman. 2007. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27: 111-122.
28. Latchman, Y. E., S. C. Liang, Y. Wu, T. Chernova, R. A. Sobel, M. Klemm, V. K. Kuchroo, G. J. Freeman, and A. H. Sharpe. 2004. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl. Acad. Sci. USA 101: 10691-10696.
29. Park, J. J., R. Omiya, Y. Matsumura, Y. Sakoda, A. Kuramasu, M. M. Augustine, S. Yao, F. Tsushima, H. Narazaki, S. Anand, et al. 2010. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood 116: 1291-1298.
30. Wilcox, R. A., A. L. Feldman, D. A. Wada, Z. Z. Yang, N. I. Comfere, H. Dong, E. D. Kwon, A. J. Novak, S. N. Markovic, M. R. Pittelkow, et al. 2009. B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood 114: 2149-2158.
31. + regulatory T cells. Proc. Natl. Acad. Sci. USA 105: 9331-9336.
32. + T lymphocytes. Immunity 20: 327-336.
33. H-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8: 345-350.
34. + T cells in transplants that can mediate chronic graft-versus-host disease. J. Immunol. 186: 856-868.
35. Wang, Y. D., W. D. Chen, M. Wang, D. Yu, B. M. Forman, and W. Huang. 2008. Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response. Hepatology 48: 1632-1643.
36. Li, N., Y. Chen, W. He, T. Yi, D. Zhao, C. Zhang, C. L. Lin, I. Todorov, F. Kandeel, S. Forman, and D. Zeng. 2009. Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI. Blood 113: 953-962.
37. Collison, L. W., C. J. Workman, T. T. Kuo, K. Boyd, Y. Wang, K. M. Vignali, R. Cross, D. Sehy, R. S. Blumberg, and D. A. Vignali. 2007. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450: 566-569.
38. Snapper, C. M., C. Peschel, and W. E. Paul. 1988. IFN-γ stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide. J. Immunol. 140: 2121-2127.
39. Collison, L. W., V. Chaturvedi, A. L. Henderson, P. R. Giacomin, C. Guy, J. Bankoti, D. Finkelstein, K. Forbes, C. J. Workman, S. A. Brown, et al. 2010. IL-35-mediated induction of a potent regulatory T cell population. Nat. Immunol. 11: 1093-1101.
40. Hirano, F., K. Kaneko, H. Tamura, H. Dong, S. Wang, M. Ichikawa, C. Rietz, D. B. Flies, J. S. Lau, G. Zhu, et al. 2005. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 65: 1089-1096. (Pubitemid 40216472)
41. + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J. Clin. Invest. 119: 551-564.
42. Keir, M. E., M. J. Butte, G. J. Freeman, and A. H. Sharpe. 2008. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704.
43. + T cells. J. Immunol. 157: 3250-3259.
44. + T cell expressed CD80 regulates central nervous system effector function and survival during experimental autoimmune encephalomyelitis. J. Immunol. 177: 2948-2958.
45. + T cells activates a calcium-dependent signaling pathway. J. Immunol. 182: 766-773.
46. Oh-hora, M., and A. Rao. 2009. The calcium/NFAT pathway: role in development and function of regulatory T cells. Microbes Infect. 11: 612-619.
47. Burman, A. C., T. Banovic, R. D. Kuns, A. D. Clouston, A. C. Stanley, E. S. Morris, V. Rowe, H. Bofinger, R. Skoczylas, N. Raffelt, et al. 2007. IFNγ differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood 110: 1064-1072. (Pubitemid 47267449)
48. Furlan, R., E. Brambilla, F. Ruffini, P. L. Poliani, A. Bergami, P. C. Marconi, D. M. Franciotta, G. Penna, G. Comi, L. Adorini, and G. Martino. 2001. Intrathecal delivery of IFN-γ protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes. J. Immunol. 167: 1821-1829. (Pubitemid 32703187)
49. Knoechel, B., J. Lohr, E. Kahn, J. A. Bluestone, and A. K. Abbas. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202: 1375-1386.
50. + regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ. Arthritis Res. Ther. 7: R402-R415.
51. + regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J. Exp. Med. 199: 25-34.
52. Sawitzki, B., C. I. Kingsley, V. Oliveira, M. Karim, M. Herber, and K. J. Wood. 2005. IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J. Exp. Med. 201: 1925-1935.