CD28, CTLA-4 and their ligands: Who does what and to whom?

Immunology

Volumn 101, Issue 2, 2000, Pages 169-177

  Sansom, D M ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; LIGAND;

ANTIGEN EXPRESSION; BINDING COMPETITION; CELL INTERACTION; CYTOKINE PRODUCTION; HUMORAL IMMUNITY; IMMUNOREGULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; HUMANS; IMMUNOCONJUGATES; LIGANDS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 0033770215     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00121.x     Document Type: Review

References (111)

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3. Regulation of surface and intracellular expression of CTLA-4 on mouse T tells
4. The role of the CD28 receptor during T cell responses to antigen
5. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation
6. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
7. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
8. Interaction of CTLA-4 with AP-50, a clathrin-coated pit adaptor protein
9. Intracellular trafficking of CTLA-4 and focal localisation towards sites of TCR engagement
10. T cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB1
11. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
12. B70 antigen is a second ligand for CTLA-4 and CD28
13. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
14. Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
15. CTLA-4 is a second receptor for the B cell activation antigen B7
16. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation
17. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
18. B7/BB1, the ligand for CD28 is expressed on repeatedly activated human T cells in vitro
19. Expression and function of the murine B7 antigen, the major costimulatoty molecule expressed on peritoneal exudate cells
20. The tissue distribution of the B7-2 costimulator in mice - Abundant expression on dendritic cells in-situ and during maturation in-vitro
21. Differential expression and modulation of costimulatory molecules CD80 and CD86 on monocytes from patients with systemic lupus erythematosus
22. Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cells
23. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2
24. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
25. Selective induction of B7/BB1 on interferon-gamma stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway
26. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2
27. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression
28. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells
29. Mutual regulation between B7-1 (CD80) expressed on T cells and IL-4
30. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
31. Role of costimulators in T cell differentiation - Studies using antigen-presenting cells lacking expression of CD80 or CD86
32. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
33. + TCR-transgenic T cells
34. Biased dependency of CD80 versus CD86 in the induction of transcription factors regulating the human IL-2 promoter
35. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
36. Human B7-1 (CD80) and 1994, B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
37. Structure and dimerization of a soluble form of B7-1
38. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo J Exp Med
39. Molecular events in the induction of a non responsive state in interleukin 2 producing helper T lymphocyte clones
40. Allogeneic non- T spleen cells restore the responsivenes of normal T cell clones stimulated with antigen and chemically modified antigen presenting cells
41. A cell culture model for T lymphocte clonal anergy
42. Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells
43. Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells
44. Murine B7 antigen provides an efficient costimulatory signal for activation of murine lymphocytes via the T cell receptor/CD3 complex
45. CD28 delivers a costimulatory signal involved in antigen specific IL-2 production by human T cells
46. CD28-mediated signalling co-stimulates murine T cells and prevents the induction of anergy in T cell clones
47. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA-4Ig
48. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
49. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
50. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival
51. Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients
52. + T cells from tolerance induction by the superantigen staphylococcal enterotoxin B
53. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
54. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
55. CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris
56. CD28: A signalling perspective
57. Differential T cell costimulatory requirements in CD28 deficient mice
58. Absence of B7-dependent responses in CD28-deficient mice
59. Induction of unresponsiveness and impaired T cell expansion by staphylococcal enterotoxin B in CD28-deficient mice
60. CD28 costimulation can promote T cell survival by enhancing expression of Bcl-X(L)
61. Activation of human T cells with superantigen and CD28 confers resistance to apoptosis by CD95
62. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
63. Expression of bcl-X (L) restores cell survival, but not proliferation and effector differentiation, in CD28-deficient T lymphocytes
64. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers
65. T cell activation determined by T cell receptor number and tunable thresholds
66. The duration of antigenic stimulation determines the fate of naive and effector T cells
67. A receptor/cytoskeletal movement triggered by costimulation during T cell activation
68. T lymphocyte costimulation mediated by reorganization of membrane microdomains1
69. + immunoregulatory T cells that control autoimmune diabetes
70. CTLA-4 can function as a negative regulator of T cell activation
71. CTLA-4 ligation blocks CD28-dependent T cell activation
72. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
73. Is CTLA-4 a negative regulator for T cell activation?
74. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
75. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
76. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
77. CTLA-4-Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
78. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
79. + T cells
80. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
81. Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells
82. + cells
83. + regulatroy T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
84. Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4 (+) T cell responses
85. Structural analysis of CTLA-4 function in vivo
86. CTLA-4-Mediated inhibition of early events of T cell proliferation
87. Regulation of T cell receptor signalling by tyrosine phosphatase SYP association with CTLA-4
88. Molecular basis of T cell inactivation by CTLA-4
89. CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts
90. B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28
91. CTLA-4 binding to lipid linkase phosphatidyl-3-kinase in T cells
92. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation
93. Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail
94. Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
95. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-β) production by murine CD4 (+) T cells
96. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
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100. + regulatory cells that control intestinal inflammation
101. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production and generation of CTL
102. Differential effects of anti-B7-1 and B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
103. CD28/B7 regulation of Th-1 and Th-2 subsets in the development of autoimmune diabetes
104. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
105. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
106. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 response
107. CD28 costimulation promotes the production of Th2 cytokines
108. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
109. The role of B7 costimulation in CD4/CD8 T cell homeostasis
110. A negative regulatory function of B7 revaled in B7-1 transgenic mice