메뉴 건너뛰기




Volumn 28, Issue 6, 2017, Pages 416-427

Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; PHOSPHODIESTERASE IV;

EID: 85014089561     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2017.02.002     Document Type: Review
Times cited : (35)

References (93)
  • 1
    • 77957278198 scopus 로고    scopus 로고
    • An inositol 1,4,5-triphosphate (IP3)-IP3 receptor pathway is required for insulin-stimulated glucose transporter 4 translocation and glucose uptake in cardiomyocytes
    • Contreras-Ferrat, A.E., An inositol 1,4,5-triphosphate (IP3)-IP3 receptor pathway is required for insulin-stimulated glucose transporter 4 translocation and glucose uptake in cardiomyocytes. Endocrinology 151 (2010), 4665–4677.
    • (2010) Endocrinology , vol.151 , pp. 4665-4677
    • Contreras-Ferrat, A.E.1
  • 2
    • 85008400398 scopus 로고    scopus 로고
    • beta-adrenergic receptor and insulin resistance in the heart
    • Mangmool, S., et al. beta-adrenergic receptor and insulin resistance in the heart. Biomol. Ther. 25 (2017), 44–56.
    • (2017) Biomol. Ther. , vol.25 , pp. 44-56
    • Mangmool, S.1
  • 3
    • 84994309796 scopus 로고    scopus 로고
    • Glucose transporters in cardiac metabolism and hypertrophy
    • Shao, D., Tian, R., Glucose transporters in cardiac metabolism and hypertrophy. Compr. Physiol. 6 (2015), 331–351.
    • (2015) Compr. Physiol. , vol.6 , pp. 331-351
    • Shao, D.1    Tian, R.2
  • 4
    • 79955782045 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia
    • Ciccarelli, M., et al. G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation 123 (2011), 1953–1962.
    • (2011) Circulation , vol.123 , pp. 1953-1962
    • Ciccarelli, M.1
  • 5
    • 77952288736 scopus 로고    scopus 로고
    • An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p
    • Rane, S., et al. An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cell. Signal. 22 (2010), 1054–1062.
    • (2010) Cell. Signal. , vol.22 , pp. 1054-1062
    • Rane, S.1
  • 6
    • 84904994548 scopus 로고    scopus 로고
    • Insulin inhibits cardiac contractility by inducing a Gi-biased beta2-adrenergic signaling in hearts
    • Fu, Q., et al. Insulin inhibits cardiac contractility by inducing a Gi-biased beta2-adrenergic signaling in hearts. Diabetes 63 (2014), 2676–2689.
    • (2014) Diabetes , vol.63 , pp. 2676-2689
    • Fu, Q.1
  • 7
    • 84913556601 scopus 로고    scopus 로고
    • Demonstration of a direct interaction between beta2-adrenergic receptor and insulin receptor by BRET and bioinformatics
    • Mandic, M., et al. Demonstration of a direct interaction between beta2-adrenergic receptor and insulin receptor by BRET and bioinformatics. PLoS One, 9, 2014, e112664.
    • (2014) PLoS One , vol.9 , pp. e112664
    • Mandic, M.1
  • 8
    • 85004065368 scopus 로고    scopus 로고
    • Markers of sympathetic nervous system activity associate with complex plasma lipids in metabolic syndrome subjects
    • Nestel, P.J., et al. Markers of sympathetic nervous system activity associate with complex plasma lipids in metabolic syndrome subjects. Atherosclerosis 256 (2016), 21–28.
    • (2016) Atherosclerosis , vol.256 , pp. 21-28
    • Nestel, P.J.1
  • 9
    • 84863283393 scopus 로고    scopus 로고
    • Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
    • Battiprolu, P.K., et al. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J. Clin. Invest. 122 (2012), 1109–1118.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1109-1118
    • Battiprolu, P.K.1
  • 10
    • 84953212764 scopus 로고    scopus 로고
    • Sustained betaAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner
    • Mangmool, S., et al. Sustained betaAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner. Mol. Endocrinol. 30 (2016), 118–132.
    • (2016) Mol. Endocrinol. , vol.30 , pp. 118-132
    • Mangmool, S.1
  • 11
    • 13444291022 scopus 로고    scopus 로고
    • Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes
    • Morisco, C., et al. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ. Res. 96 (2005), 180–188.
    • (2005) Circ. Res. , vol.96 , pp. 180-188
    • Morisco, C.1
  • 12
    • 85000770394 scopus 로고    scopus 로고
    • Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control
    • Inoue, T., et al. Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control. BMJ Open Diabetes Res. Care, 4, 2016, e000223.
    • (2016) BMJ Open Diabetes Res. Care , vol.4 , pp. e000223
    • Inoue, T.1
  • 13
    • 84871749894 scopus 로고    scopus 로고
    • Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation
    • Zhu, Y., et al. Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation. Mol. Endocrinol. 27 (2013), 172–184.
    • (2013) Mol. Endocrinol. , vol.27 , pp. 172-184
    • Zhu, Y.1
  • 14
    • 84951807748 scopus 로고    scopus 로고
    • Chronic hyperinsulinemia causes selective insulin resistance and down-regulates uncoupling protein 3 (UCP3) through the activation of sterol regulatory element-binding protein (SREBP)-1 transcription factor in the mouse heart
    • Harmancey, R., et al. Chronic hyperinsulinemia causes selective insulin resistance and down-regulates uncoupling protein 3 (UCP3) through the activation of sterol regulatory element-binding protein (SREBP)-1 transcription factor in the mouse heart. J. Biol. Chem. 290 (2015), 30947–30961.
    • (2015) J. Biol. Chem. , vol.290 , pp. 30947-30961
    • Harmancey, R.1
  • 15
    • 84855453214 scopus 로고    scopus 로고
    • p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure
    • Shimizu, I., et al. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab. 15 (2012), 51–64.
    • (2012) Cell Metab. , vol.15 , pp. 51-64
    • Shimizu, I.1
  • 16
    • 84947437819 scopus 로고    scopus 로고
    • Beta-adrenergic blockade increases GLUT4 and improves glycemic control in insulin-treated diabetic Wistar rats
    • Alves-Wagner, A.B., Beta-adrenergic blockade increases GLUT4 and improves glycemic control in insulin-treated diabetic Wistar rats. Auton. Neurosci. 193 (2015), 108–116.
    • (2015) Auton. Neurosci. , vol.193 , pp. 108-116
    • Alves-Wagner, A.B.1
  • 17
    • 84858706089 scopus 로고    scopus 로고
    • Differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome
    • Ayers, K., et al. Differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome. Hypertension 59 (2012), 893–898.
    • (2012) Hypertension , vol.59 , pp. 893-898
    • Ayers, K.1
  • 18
    • 79551494642 scopus 로고    scopus 로고
    • Improved diabetic control in advanced heart failure patients treated with left ventricular assist devices
    • Uriel, N., et al. Improved diabetic control in advanced heart failure patients treated with left ventricular assist devices. Eur. J. Heart Fail. 13 (2011), 195–199.
    • (2011) Eur. J. Heart Fail. , vol.13 , pp. 195-199
    • Uriel, N.1
  • 19
    • 84994723646 scopus 로고    scopus 로고
    • Interaction of beta1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling
    • Zhu, W., et al. Interaction of beta1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling. JCI Insight, 1, 2016, e84969.
    • (2016) JCI Insight , vol.1 , pp. e84969
    • Zhu, W.1
  • 20
    • 84875604499 scopus 로고    scopus 로고
    • Conformational biosensors reveal GPCR signalling from endosomes
    • Irannejad, R., et al. Conformational biosensors reveal GPCR signalling from endosomes. Nature 495 (2013), 534–538.
    • (2013) Nature , vol.495 , pp. 534-538
    • Irannejad, R.1
  • 21
    • 41149180568 scopus 로고    scopus 로고
    • Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes
    • Morisco, C., et al. Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes. Cardiovasc. Res. 78 (2008), 36–44.
    • (2008) Cardiovasc. Res. , vol.78 , pp. 36-44
    • Morisco, C.1
  • 22
    • 84946176992 scopus 로고    scopus 로고
    • Trafficking of beta-adrenergic receptors: implications in intracellular receptor signaling
    • Fu, Q., Xiang, Y.K., Trafficking of beta-adrenergic receptors: implications in intracellular receptor signaling. Prog. Mol. Biol. Transl. Sci. 132 (2015), 151–188.
    • (2015) Prog. Mol. Biol. Transl. Sci. , vol.132 , pp. 151-188
    • Fu, Q.1    Xiang, Y.K.2
  • 23
    • 77950286813 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
    • Nikolaev, V.O., et al. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science 327 (2010), 1653–1657.
    • (2010) Science , vol.327 , pp. 1653-1657
    • Nikolaev, V.O.1
  • 24
    • 84987654715 scopus 로고    scopus 로고
    • Genetically encoded biosensors reveal PKA hyperphosphorylation on the myofilaments in rabbit heart failure
    • Barbagallo, F., et al. Genetically encoded biosensors reveal PKA hyperphosphorylation on the myofilaments in rabbit heart failure. Circ. Res. 119 (2016), 931–943.
    • (2016) Circ. Res. , vol.119 , pp. 931-943
    • Barbagallo, F.1
  • 25
    • 79960346334 scopus 로고    scopus 로고
    • Compartmentalization of beta-adrenergic signals in cardiomyocytes
    • Xiang, Y.K., Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ. Res. 109 (2011), 231–244.
    • (2011) Circ. Res. , vol.109 , pp. 231-244
    • Xiang, Y.K.1
  • 26
    • 84953250455 scopus 로고    scopus 로고
    • Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of beta2-AR/PI3K/AKT signaling pathway
    • Wu, M.P., et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of beta2-AR/PI3K/AKT signaling pathway. Pharmacol. Res. 104 (2016), 115–123.
    • (2016) Pharmacol. Res. , vol.104 , pp. 115-123
    • Wu, M.P.1
  • 27
    • 84949519043 scopus 로고    scopus 로고
    • Biased beta2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery
    • Woo, A.Y., et al. Biased beta2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery. Br. J. Pharmacol. 172 (2015), 5444–5456.
    • (2015) Br. J. Pharmacol. , vol.172 , pp. 5444-5456
    • Woo, A.Y.1
  • 28
    • 84988458382 scopus 로고    scopus 로고
    • Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: findings from get with the guidelines-heart failure registry
    • Echouffo-Tcheugui, J.B., Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: findings from get with the guidelines-heart failure registry. Am. Heart J. 182 (2016), 9–20.
    • (2016) Am. Heart J. , vol.182 , pp. 9-20
    • Echouffo-Tcheugui, J.B.1
  • 29
    • 85019701932 scopus 로고    scopus 로고
    • Novel protein glycan-derived markers of systemic inflammation and C-reactive protein in relation to glycemia, insulin resistance, and insulin secretion
    • Published online December 28, 2016
    • Lorenzo, C., et al. Novel protein glycan-derived markers of systemic inflammation and C-reactive protein in relation to glycemia, insulin resistance, and insulin secretion. Diabetes Care, 2016, 10.2337/dc16-1569 Published online December 28, 2016.
    • (2016) Diabetes Care
    • Lorenzo, C.1
  • 30
    • 84927575168 scopus 로고    scopus 로고
    • Heart failure: mitochondrial dysfunction and oxidative stress in CHF
    • Okonko, D.O., Shah, A.M., Heart failure: mitochondrial dysfunction and oxidative stress in CHF. Nat. Rev. Cardiol. 12 (2015), 6–8.
    • (2015) Nat. Rev. Cardiol. , vol.12 , pp. 6-8
    • Okonko, D.O.1    Shah, A.M.2
  • 31
    • 84988613811 scopus 로고    scopus 로고
    • The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice
    • Boly, C.A., et al. The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice. Cardiovasc. Diabetol., 15, 2016, 135.
    • (2016) Cardiovasc. Diabetol. , vol.15 , pp. 135
    • Boly, C.A.1
  • 32
    • 84922594993 scopus 로고    scopus 로고
    • Insulin induces IRS2-dependent and GRK2-mediated beta2AR internalization to attenuate betaAR signaling in cardiomyocytes
    • Fu, Q., et al. Insulin induces IRS2-dependent and GRK2-mediated beta2AR internalization to attenuate betaAR signaling in cardiomyocytes. Cell. Signal. 27 (2015), 707–715.
    • (2015) Cell. Signal. , vol.27 , pp. 707-715
    • Fu, Q.1
  • 33
    • 84997040259 scopus 로고    scopus 로고
    • Inhibiting insulin-mediated beta2AR activation prevents diabetes-associated cardiac dysfunction
    • Wang, Q., et al. Inhibiting insulin-mediated beta2AR activation prevents diabetes-associated cardiac dysfunction. Circulation 135 (2016), 73–88.
    • (2016) Circulation , vol.135 , pp. 73-88
    • Wang, Q.1
  • 34
    • 85011691071 scopus 로고    scopus 로고
    • High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2-adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts
    • Published online
    • Fu, Q., et al. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2-adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. J. Physiol., 2016, 10.1113/JP273314 Published online.
    • (2016) J. Physiol.
    • Fu, Q.1
  • 35
    • 84999652745 scopus 로고    scopus 로고
    • The role of reactive oxygen species in beta-adrenergic signaling in cardiomyocytes from mice with the metabolic syndrome
    • Llano-Diez, M., et al. The role of reactive oxygen species in beta-adrenergic signaling in cardiomyocytes from mice with the metabolic syndrome. PLoS One, 11, 2016, e0167090.
    • (2016) PLoS One , vol.11 , pp. e0167090
    • Llano-Diez, M.1
  • 36
    • 85006277085 scopus 로고    scopus 로고
    • beta-adrenergic responsiveness in the type 2 diabetic heart: effects on cardiac reserve
    • Published online December 14, 2016
    • Wilson, G.A., et al. beta-adrenergic responsiveness in the type 2 diabetic heart: effects on cardiac reserve. Med. Sci. Sports Exerc., 2016, 10.1249/MSS.0000000000001184 Published online December 14, 2016.
    • (2016) Med. Sci. Sports Exerc.
    • Wilson, G.A.1
  • 37
    • 84901449344 scopus 로고    scopus 로고
    • A long lasting beta1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes
    • Fu, Q., et al. A long lasting beta1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J. Biol. Chem. 289 (2014), 14771–14781.
    • (2014) J. Biol. Chem. , vol.289 , pp. 14771-14781
    • Fu, Q.1
  • 38
    • 84942520519 scopus 로고    scopus 로고
    • Interaction between phosphodiesterases in the regulation of the cardiac beta-adrenergic pathway
    • Zhao, C.Y., et al. Interaction between phosphodiesterases in the regulation of the cardiac beta-adrenergic pathway. J. Mol. Cell Cardiol. 88 (2015), 29–38.
    • (2015) J. Mol. Cell Cardiol. , vol.88 , pp. 29-38
    • Zhao, C.Y.1
  • 39
    • 84864349212 scopus 로고    scopus 로고
    • Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis
    • Pantalone, K.M., et al. Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis. Diabetes Obes. Metab. 14 (2012), 803–809.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 803-809
    • Pantalone, K.M.1
  • 40
    • 85006437105 scopus 로고    scopus 로고
    • Comparable attenuation of sympathetic nervous system activity in obese subjects with normal glucose tolerance, impaired glucose tolerance, and treatment naive type 2 diabetes following equivalent weight loss
    • Straznicky, N.E., et al. Comparable attenuation of sympathetic nervous system activity in obese subjects with normal glucose tolerance, impaired glucose tolerance, and treatment naive type 2 diabetes following equivalent weight loss. Front. Physiol., 7, 2016, 516.
    • (2016) Front. Physiol. , vol.7 , pp. 516
    • Straznicky, N.E.1
  • 41
    • 85008507504 scopus 로고    scopus 로고
    • Galectin-3 and fibulin-1 in systolic heart failure - relation to glucose metabolism and left ventricular contractile reserve
    • Holmager, P., et al. Galectin-3 and fibulin-1 in systolic heart failure - relation to glucose metabolism and left ventricular contractile reserve. BMC Cardiovasc. Disord., 17, 2017, 22.
    • (2017) BMC Cardiovasc. Disord. , vol.17 , pp. 22
    • Holmager, P.1
  • 42
    • 84878324997 scopus 로고    scopus 로고
    • Abnormal myocardial perfusion and risk of heart failure in patients with type 2 diabetes mellitus
    • Utrera-Lagunas, M., Abnormal myocardial perfusion and risk of heart failure in patients with type 2 diabetes mellitus. Exp. Clin. Cardiol. 18 (2013), e44–e46.
    • (2013) Exp. Clin. Cardiol. , vol.18 , pp. e44-e46
    • Utrera-Lagunas, M.1
  • 43
    • 84996629771 scopus 로고    scopus 로고
    • Association of insulin resistance and glycemic metabolic abnormalities with LV structure and function in middle age: the CARDIA study
    • Published online August 11, 2016
    • Kishi, S., et al. Association of insulin resistance and glycemic metabolic abnormalities with LV structure and function in middle age: the CARDIA study. JACC Cardiovasc. Imaging, 2016, 10.1016/j.jcmg.2016.02.033 Published online August 11, 2016.
    • (2016) JACC Cardiovasc. Imaging
    • Kishi, S.1
  • 44
    • 79961051091 scopus 로고    scopus 로고
    • Taking the heart failure battle inside the cell: small molecule targeting of Gbetagamma subunits
    • Kamal, F.A., et al. Taking the heart failure battle inside the cell: small molecule targeting of Gbetagamma subunits. J. Mol. Cell. Cardiol. 51 (2011), 462–467.
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 462-467
    • Kamal, F.A.1
  • 45
    • 84926611120 scopus 로고    scopus 로고
    • The evolving impact of g protein-coupled receptor kinases in cardiac health and disease
    • Sato, P.Y., et al. The evolving impact of g protein-coupled receptor kinases in cardiac health and disease. Physiol. Rev. 95 (2015), 377–404.
    • (2015) Physiol. Rev. , vol.95 , pp. 377-404
    • Sato, P.Y.1
  • 46
    • 77956226186 scopus 로고    scopus 로고
    • Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure
    • Casey, L.M., et al. Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure. Circ. Res. 107 (2010), 532–539.
    • (2010) Circ. Res. , vol.107 , pp. 532-539
    • Casey, L.M.1
  • 47
    • 84869435029 scopus 로고    scopus 로고
    • Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility
    • Thal, D.M., et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem. Biol. 7 (2012), 1830–1839.
    • (2012) ACS Chem. Biol. , vol.7 , pp. 1830-1839
    • Thal, D.M.1
  • 48
    • 84929001066 scopus 로고    scopus 로고
    • Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction
    • Schumacher, S.M., et al. Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction. Sci. Transl. Med., 7, 2015, 277ra31.
    • (2015) Sci. Transl. Med. , vol.7 , pp. 277ra31
    • Schumacher, S.M.1
  • 49
    • 84960087595 scopus 로고    scopus 로고
    • Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells
    • Horinouchi, T., et al. Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells. Br. J. Pharmacol. 173 (2016), 1018–1032.
    • (2016) Br. J. Pharmacol. , vol.173 , pp. 1018-1032
    • Horinouchi, T.1
  • 50
    • 84995366693 scopus 로고    scopus 로고
    • Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels
    • Lucas, E., et al. Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels. Cardiovasc. Diabetol., 15, 2016, 155.
    • (2016) Cardiovasc. Diabetol. , vol.15 , pp. 155
    • Lucas, E.1
  • 51
    • 84921450860 scopus 로고    scopus 로고
    • Impact of diabetes mellitus on lymphocyte GRK2 protein levels in patients with heart failure
    • Rengo, G., et al. Impact of diabetes mellitus on lymphocyte GRK2 protein levels in patients with heart failure. Eur. J. Clin. Invest. 45 (2015), 187–195.
    • (2015) Eur. J. Clin. Invest. , vol.45 , pp. 187-195
    • Rengo, G.1
  • 52
    • 84910029573 scopus 로고    scopus 로고
    • Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns
    • Lucas, E., et al. Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns. Biochim. Biophys. Acta 1842:12 Pt A (2014), 2448–2456.
    • (2014) Biochim. Biophys. Acta , vol.1842 , Issue.12 , pp. 2448-2456
    • Lucas, E.1
  • 53
    • 84937704367 scopus 로고    scopus 로고
    • Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2
    • Vila-Bedmar, R., et al. Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2. Sci. Signal., 8, 2015, ra73.
    • (2015) Sci. Signal. , vol.8 , pp. ra73
    • Vila-Bedmar, R.1
  • 54
    • 84856427725 scopus 로고    scopus 로고
    • GRK2 at the control shaft of cellular metabolism
    • Ciccarelli, M., et al. GRK2 at the control shaft of cellular metabolism. Curr. Pharm. Des. 18 (2012), 121–127.
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 121-127
    • Ciccarelli, M.1
  • 55
    • 77951773194 scopus 로고    scopus 로고
    • Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents
    • Shimizu, I., et al. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J. Clin. Invest. 120 (2010), 1506–1514.
    • (2010) J. Clin. Invest. , vol.120 , pp. 1506-1514
    • Shimizu, I.1
  • 56
    • 84906061866 scopus 로고    scopus 로고
    • Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training
    • Riehle, C., et al. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Mol. Cell. Biol. 34 (2014), 3450–3460.
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 3450-3460
    • Riehle, C.1
  • 57
    • 84871518109 scopus 로고    scopus 로고
    • Molecular basis of physiological heart growth: fundamental concepts and new players
    • Maillet, M., et al. Molecular basis of physiological heart growth: fundamental concepts and new players. Nat. Rev. Mol. Cell Biol. 14 (2013), 38–48.
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 38-48
    • Maillet, M.1
  • 58
    • 84964413063 scopus 로고    scopus 로고
    • Distinct endothelial cell responses in the heart and kidney microvasculature characterize the progression of heart failure with preserved ejection fraction in the obese ZSF1 rat with cardiorenal metabolic syndrome
    • van Dijk, C.G., et al. Distinct endothelial cell responses in the heart and kidney microvasculature characterize the progression of heart failure with preserved ejection fraction in the obese ZSF1 rat with cardiorenal metabolic syndrome. Circ. Heart Fail., 9, 2016, e002760.
    • (2016) Circ. Heart Fail. , vol.9 , pp. e002760
    • van Dijk, C.G.1
  • 59
    • 84942827206 scopus 로고    scopus 로고
    • PPARgamma-PI3K/AKT-NO signal pathway is involved in cardiomyocyte hypertrophy induced by high glucose and insulin
    • Peng, X., et al. PPARgamma-PI3K/AKT-NO signal pathway is involved in cardiomyocyte hypertrophy induced by high glucose and insulin. J. Diabetes Complications 29 (2015), 755–760.
    • (2015) J. Diabetes Complications , vol.29 , pp. 755-760
    • Peng, X.1
  • 60
    • 84995528351 scopus 로고    scopus 로고
    • Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3beta signaling
    • Chowdhury, D., et al. Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3beta signaling. Mol. Cell. Biochem. 425 (2017), 155–168.
    • (2017) Mol. Cell. Biochem. , vol.425 , pp. 155-168
    • Chowdhury, D.1
  • 61
    • 84988811694 scopus 로고    scopus 로고
    • TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner
    • Yang, B., et al. TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner. Am. J. Transl. Res. 8 (2016), 3848–3860.
    • (2016) Am. J. Transl. Res. , vol.8 , pp. 3848-3860
    • Yang, B.1
  • 62
    • 84946489752 scopus 로고    scopus 로고
    • Increased cardiac remodeling in cardiac-specific Flt-1 receptor knockout mice with pressure overload
    • Mei, L., et al. Increased cardiac remodeling in cardiac-specific Flt-1 receptor knockout mice with pressure overload. Cell Tissue Res. 362 (2015), 389–398.
    • (2015) Cell Tissue Res. , vol.362 , pp. 389-398
    • Mei, L.1
  • 63
    • 84867711595 scopus 로고    scopus 로고
    • beta-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gbetagamma/Erk-dependent pathway
    • Vidal, M., et al. beta-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gbetagamma/Erk-dependent pathway. Cardiovasc. Res. 96 (2012), 255–264.
    • (2012) Cardiovasc. Res. , vol.96 , pp. 255-264
    • Vidal, M.1
  • 64
    • 79952792120 scopus 로고    scopus 로고
    • Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1
    • Bhavsar, P.K., et al. Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1. J. Cardiovasc. Transl. Res. 3 (2010), 688–695.
    • (2010) J. Cardiovasc. Transl. Res. , vol.3 , pp. 688-695
    • Bhavsar, P.K.1
  • 65
    • 84155180926 scopus 로고    scopus 로고
    • beta2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo
    • Murray, D.R., et al. beta2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. J. Mol. Cell Cardiol. 52 (2012), 206–218.
    • (2012) J. Mol. Cell Cardiol. , vol.52 , pp. 206-218
    • Murray, D.R.1
  • 66
    • 84857643399 scopus 로고    scopus 로고
    • Reverse remodeling in heart failure?mechanisms and therapeutic opportunities
    • Koitabashi, N., Kass, D.A., Reverse remodeling in heart failure?mechanisms and therapeutic opportunities. Nat. Rev. Cardiol. 9 (2011), 147–157.
    • (2011) Nat. Rev. Cardiol. , vol.9 , pp. 147-157
    • Koitabashi, N.1    Kass, D.A.2
  • 67
    • 84992702465 scopus 로고    scopus 로고
    • The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance
    • Published online August 4, 2016
    • Ramalingam, L., et al. The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochim. Biophys. Acta, 2016, 10.1016/j.bbadis.2016.07.019 Published online August 4, 2016.
    • (2016) Biochim. Biophys. Acta
    • Ramalingam, L.1
  • 68
    • 84884532534 scopus 로고    scopus 로고
    • Metabolic actions of angiotensin II and insulin: a microvascular endothelial balancing act
    • Muniyappa, R., Yavuz, S., Metabolic actions of angiotensin II and insulin: a microvascular endothelial balancing act. Mol. Cell Endocrinol. 378 (2013), 59–69.
    • (2013) Mol. Cell Endocrinol. , vol.378 , pp. 59-69
    • Muniyappa, R.1    Yavuz, S.2
  • 69
    • 84964507430 scopus 로고    scopus 로고
    • High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy
    • Huang, J.P., et al. High-fructose and high-fat feeding correspondingly lead to the development of lysoPC-associated apoptotic cardiomyopathy and adrenergic signaling-related cardiac hypertrophy. Int. J Cardiol. 215 (2016), 65–76.
    • (2016) Int. J Cardiol. , vol.215 , pp. 65-76
    • Huang, J.P.1
  • 70
    • 85010505660 scopus 로고    scopus 로고
    • Beta2-adrenergic signaling affects the phenotype of human cardiac progenitor cells through EMT modulation
    • Published online January 7, 2017
    • Pagano, F., et al. Beta2-adrenergic signaling affects the phenotype of human cardiac progenitor cells through EMT modulation. Pharmacol. Res., 2017, 10.1016/j.phrs.2017.01.016 Published online January 7, 2017.
    • (2017) Pharmacol. Res.
    • Pagano, F.1
  • 71
    • 84991720209 scopus 로고    scopus 로고
    • CaMKII induces permeability transition through Drp1 phosphorylation during chronic beta-AR stimulation
    • Xu, S., et al. CaMKII induces permeability transition through Drp1 phosphorylation during chronic beta-AR stimulation. Nat. Commun., 7, 2016, 13189.
    • (2016) Nat. Commun. , vol.7 , pp. 13189
    • Xu, S.1
  • 72
    • 84907538533 scopus 로고    scopus 로고
    • Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation
    • Ambrose, L.J., et al. Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation. J. Cardiovasc. Pharmacol. Ther. 19 (2014), 574–585.
    • (2014) J. Cardiovasc. Pharmacol. Ther. , vol.19 , pp. 574-585
    • Ambrose, L.J.1
  • 73
    • 84944810078 scopus 로고    scopus 로고
    • Increased energy demand during adrenergic receptor stimulation contributes to Ca(2+) wave generation
    • Bovo, E., et al. Increased energy demand during adrenergic receptor stimulation contributes to Ca(2+) wave generation. Biophys. J. 109 (2015), 1583–1591.
    • (2015) Biophys. J. , vol.109 , pp. 1583-1591
    • Bovo, E.1
  • 74
    • 84903535463 scopus 로고    scopus 로고
    • Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3beta to regulate aerobic glycolysis
    • Landis, J., Shaw, L.M., Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3beta to regulate aerobic glycolysis. J. Biol. Chem. 289 (2014), 18603–18613.
    • (2014) J. Biol. Chem. , vol.289 , pp. 18603-18613
    • Landis, J.1    Shaw, L.M.2
  • 75
    • 79960564311 scopus 로고    scopus 로고
    • R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals
    • Kelsall, I.R., et al. R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals. J. Neurochem. 118 (2011), 596–610.
    • (2011) J. Neurochem. , vol.118 , pp. 596-610
    • Kelsall, I.R.1
  • 76
    • 84925457539 scopus 로고    scopus 로고
    • Myocardial glycogen dynamics: new perspectives on disease mechanisms
    • Chandramouli, C., et al. Myocardial glycogen dynamics: new perspectives on disease mechanisms. Clin. Exp. Pharmacol. Physiol. 42 (2015), 415–425.
    • (2015) Clin. Exp. Pharmacol. Physiol. , vol.42 , pp. 415-425
    • Chandramouli, C.1
  • 77
    • 84902313581 scopus 로고    scopus 로고
    • Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action
    • Martin, S.D., et al. Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action. Mol. Metab. 3 (2014), 408–418.
    • (2014) Mol. Metab. , vol.3 , pp. 408-418
    • Martin, S.D.1
  • 78
    • 84985905161 scopus 로고    scopus 로고
    • The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high-glucose-induced injured H9c2 cardiomyoblasts
    • Ji, L., et al. The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high-glucose-induced injured H9c2 cardiomyoblasts. Can. J. Physiol. Pharmacol. 94 (2016), 996–1006.
    • (2016) Can. J. Physiol. Pharmacol. , vol.94 , pp. 996-1006
    • Ji, L.1
  • 79
    • 85008625948 scopus 로고    scopus 로고
    • Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice
    • Manna, P., et al. Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice. Arch. Biochem. Biophys. 615 (2017), 22–34.
    • (2017) Arch. Biochem. Biophys. , vol.615 , pp. 22-34
    • Manna, P.1
  • 80
    • 84861762743 scopus 로고    scopus 로고
    • Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat
    • Ma, L., et al. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. Am. J. Physiol. Heart Circ. Physiol. 302 (2012), H2341–H2351.
    • (2012) Am. J. Physiol. Heart Circ. Physiol. , vol.302 , pp. H2341-H2351
    • Ma, L.1
  • 81
    • 84938828500 scopus 로고    scopus 로고
    • Rutaecarpine and evodiamine selected as beta1-AR inhibitor candidates using beta1-AR/CMC-offline-UPLC/MS prevent cardiac ischemia-reperfusion injury via energy modulation
    • Xue, H., et al. Rutaecarpine and evodiamine selected as beta1-AR inhibitor candidates using beta1-AR/CMC-offline-UPLC/MS prevent cardiac ischemia-reperfusion injury via energy modulation. J. Pharm. Biomed. Anal. 115 (2015), 307–314.
    • (2015) J. Pharm. Biomed. Anal. , vol.115 , pp. 307-314
    • Xue, H.1
  • 82
    • 84983628302 scopus 로고    scopus 로고
    • Carvedilol-responsive microRNAs, miR-199a-3p and -214 protect cardiomyocytes from simulated ischemia-reperfusion injury
    • Park, K.M., et al. Carvedilol-responsive microRNAs, miR-199a-3p and -214 protect cardiomyocytes from simulated ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 311 (2016), H371–H383.
    • (2016) Am. J. Physiol. Heart Circ. Physiol. , vol.311 , pp. H371-H383
    • Park, K.M.1
  • 83
    • 84962791574 scopus 로고    scopus 로고
    • Therapeutic synergy and complementarity for ischemia/reperfusion injury: beta1-adrenergic blockade and phosphodiesterase-3 inhibition
    • Huang, M.H., et al. Therapeutic synergy and complementarity for ischemia/reperfusion injury: beta1-adrenergic blockade and phosphodiesterase-3 inhibition. Int. J. Cardiol. 214 (2016), 374–380.
    • (2016) Int. J. Cardiol. , vol.214 , pp. 374-380
    • Huang, M.H.1
  • 84
    • 77954061566 scopus 로고    scopus 로고
    • Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats
    • Zhang, Q., et al. Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats. Br. J. Pharmacol. 160 (2010), 1561–1572.
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 1561-1572
    • Zhang, Q.1
  • 85
    • 80053221896 scopus 로고    scopus 로고
    • beta2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways
    • Fajardo, G., et al. beta2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways. J. Mol. Cell Cardiol. 51 (2011), 781–789.
    • (2011) J. Mol. Cell Cardiol. , vol.51 , pp. 781-789
    • Fajardo, G.1
  • 86
    • 84978128490 scopus 로고    scopus 로고
    • beta-arrestin-biased signaling through the beta2-adrenergic receptor promotes cardiomyocyte contraction
    • Carr 3rd, R., et al. beta-arrestin-biased signaling through the beta2-adrenergic receptor promotes cardiomyocyte contraction. Proc. Natl. Acad. Sci. U. S. A. 113 (2016), E4107–E4116.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , pp. E4107-E4116
    • Carr, R.1
  • 87
    • 84864286944 scopus 로고    scopus 로고
    • Selective beta2-adrenoreceptor stimulation attenuates myocardial cell death and preserves cardiac function after ischemia-reperfusion injury
    • Bhushan, S., et al. Selective beta2-adrenoreceptor stimulation attenuates myocardial cell death and preserves cardiac function after ischemia-reperfusion injury. Arterioscler. Thromb. Vasc. Biol. 32 (2012), 1865–1874.
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 1865-1874
    • Bhushan, S.1
  • 88
    • 84890116705 scopus 로고    scopus 로고
    • The heart is better protected against myocardial infarction in the fed state compared to the fasted state
    • Liepinsh, E., et al. The heart is better protected against myocardial infarction in the fed state compared to the fasted state. Metabolism 63 (2014), 127–136.
    • (2014) Metabolism , vol.63 , pp. 127-136
    • Liepinsh, E.1
  • 89
    • 77949783907 scopus 로고    scopus 로고
    • Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
    • Ji, L., et al. Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress. Am. J. Physiol. Endocrinol. Metab. 298 (2010), E871–E880.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , pp. E871-E880
    • Ji, L.1
  • 90
    • 84925883988 scopus 로고    scopus 로고
    • High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury
    • Salie, R., et al. High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury. Cardiovasc. Diabetol., 13, 2014, 109.
    • (2014) Cardiovasc. Diabetol. , vol.13 , pp. 109
    • Salie, R.1
  • 91
    • 84893407463 scopus 로고    scopus 로고
    • Glucosa-insulin-potassium (GIK) solution used with diabetic patients provides better recovery after coronary bypass operations
    • Straus, S., et al. Glucosa-insulin-potassium (GIK) solution used with diabetic patients provides better recovery after coronary bypass operations. Med. Arch. 67 (2013), 84–87.
    • (2013) Med. Arch. , vol.67 , pp. 84-87
    • Straus, S.1
  • 92
    • 84949218414 scopus 로고    scopus 로고
    • Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial
    • Published online December 9, 2016
    • Ellis, K.L., et al. Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial. Pharmacogenomics, 2016, 10.1038/tpj.2015.84 Published online December 9, 2016.
    • (2016) Pharmacogenomics
    • Ellis, K.L.1
  • 93
    • 85007297398 scopus 로고    scopus 로고
    • Insulin signaling and heart failure
    • Riehle, C., Abel, E.D., Insulin signaling and heart failure. Circulation Res. 118 (2016), 1151–1169.
    • (2016) Circulation Res. , vol.118 , pp. 1151-1169
    • Riehle, C.1    Abel, E.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.