Compartmentalization of β-adrenergic signals in cardiomyocytes

Circulation Research

Volumn 109, Issue 2, 2011, Pages 231-244

  Xiang, Yang K ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

adrenergic receptor; phosphodiesterase; protein kinase A

Indexed keywords

ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IIIA; PHOSPHODIESTERASE IIIB; PHOSPHODIESTERASE IV; PHOSPHOLAMBAN; TROPONIN I; UNCLASSIFIED DRUG;

ACCURACY; ADRENERGIC SYSTEM; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME SYNTHESIS; GENE EXPRESSION; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HUMAN; INTRACELLULAR SIGNALING; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SYMPATHETIC GANGLION;

ADENYLATE CYCLASE; HUMANS; MYOCYTES, CARDIAC; PHOSPHORIC DIESTER HYDROLASES; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION;

EID: 79960346334     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.231340     Document Type: Review

References (146)

1. Xiang Y, Kobilka BK. Myocyte adrenoceptor signaling pathways. Science. 2003;300:1530-1532. (Pubitemid 36682874)
2. Xiao RP, Zhu W, Zheng M, Cao C, Zhang Y, Lakatta EG, Han Q. Subtype-specific alpha1-and beta-adrenoceptor signaling in the heart. Trends Pharmacol Sci. 2006;27:330-337. (Pubitemid 43850004)
3. Lefkowitz RJ. Seven transmembrane receptors: Something old, something new. Acta Physiol (Oxf). 2007;190:9-19. (Pubitemid 46570176)
4. Salazar NC, Chen J, Rockman HA. Cardiac GPCR: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta. 2007;1768: 1006-1018. (Pubitemid 46463942)
5. Dorn GW II, Liggett SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clin Transl Sci. 2008;1:255-262.
6. Pleger ST, Boucher M, Most P, Koch WJ. Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapy. J Card Fail. 2007;13:401-414. (Pubitemid 46977786)
7. Rasmussen HH, Figtree GA, Krum H, Bundgaard H. The use of beta3-adrenergic receptor agonists in the treatment of heart failure. Curr Opin Invest Drugs. 2009;10:955-962.
8. Zaccolo M. cAMP signal transduction in the heart: Understanding spatial control for the development of novel therapeutic strategies. Br J Pharmacol. 2009;158:50-60.
9. Zaccolo M, Movsesian MA. cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology. Circ Res. 2007;100:1569-1578. (Pubitemid 46897260)
10. McConnachie G, Langeberg LK, Scott JD. AKAP signaling complexes: getting to the heart of the matter. Trends Mol Med. 2006;12:317-323. (Pubitemid 44110003)
11. Carnegie GK, Means CK, Scott JD. A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life. 2009;61: 394-406.
12. Mauban JR, O'Donnell M, Warrier S, Manni S, Bond M. Akap-scaffolding proteins and regulation of cardiac physiology. Physiology (Bethesda). 2009;24:78-87.
13. Steinberg SF, Brunton LL. Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol. 2001;41:751-773. (Pubitemid 32385905)
14. Houslay MD, Baillie GS, Maurice DH. cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ Res. 2007;100:950-966. (Pubitemid 46598920)
15. Cooper DM. Compartmentalization of adenylate cyclase and cAMP signalling. Biochem Soc Trans. 2005;33:1319-1322. (Pubitemid 41779677)
16. Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechêne P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G. Spatiotemporal dynamics of beta-adrenergic cAMP signals and l-type Ca2+ channel regulation in adult rat ventricular myocytes: Role of phosphodiesterases. Circ Res. 2008;102:1091-1100. (Pubitemid 351667863)
17. Rochais F, Vilardaga JP, Nikolaev VO, Bünemann M, Lohse MJ, Engelhardt S. Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J Clin Invest. 2007;117:229-235. (Pubitemid 46048469)
18. Jarnaess E, Taskén K. Spatiotemporal control of cAMP signalling processes by anchored signalling complexes. Biochem Soc Trans. 2007;35: 931-937. (Pubitemid 350206399)
19. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005;123:25-35. (Pubitemid 41414526)
20. Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science. 2002;295:496-499. (Pubitemid 34101639)
21. Communal C, Singh K, Pimentel DR, Colucci WS. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation. 1998;98:1329-1334. (Pubitemid 28443398)
22. Singh K, Xiao L, Remondino A, Sawyer DB, Colucci WS. Adrenergic regulation of cardiac myocyte apoptosis. J Cell Physiol. 2001;189: 257-265. (Pubitemid 33063293)
23. Singh K, Communal C, Sawyer DB, Colucci WS. Adrenergic regulation of myocardial apoptosis. Cardiovasc Res. 2000;45:713-719. (Pubitemid 30047138)
24. Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase a-independent activation of Ca2+/calmodulin kinase II. J Clin Invest. 2003;111: 617-625. (Pubitemid 36278580)
25. Choi DJ, Rockman HA. Beta-adrenergic receptor desensitization in cardiac hypertrophy and heart failure. Cell Biochem Biophys. 1999;31: 321-329. (Pubitemid 129548433)
26. Sugden PH. Signalling pathways in cardiac myocyte hypertrophy. Ann Med. 2001;33:611-622. (Pubitemid 34081499)
27. Patel HH, Murray F, Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol. 2008;48:359-391. (Pubitemid 351738158)
28. Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW, Kobilka BK. Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes. J Cell Biol. 2007;176:521-533.
29. Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD. Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell. 2006;23:925-931. (Pubitemid 44363046)
30. Fraser ID, Cong M, Kim J, Rollins EN, Daaka Y, Lefkowitz RJ, Scott JD. Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr Biol. 2000;10:409-412. (Pubitemid 30213389)
31. Malbon CC. A-kinase anchoring proteins: Trafficking in G-protein-coupled receptors and the proteins that regulate receptor biology. Curr Opin Drug Discov Devel. 2007;10:573-579. (Pubitemid 47367772)
32. Gardner LA, Tavalin SJ, Goehring AS, Scott JD, Bahouth SW. AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem. 2006;281:33537-33553. (Pubitemid 46036735)
33. De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK. Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol. 2010;78:340-349.
34. Richter W, Day P, Agrawal R, Bruss MD, Granier S, Wang YL, Rasmussen SG, Horner K, Wang P, Lei T, Patterson AJ, Kobilka B, Conti M. Signaling from beta1-and beta2-adrenergic receptors is defined by differential interactions with PDE4. Embo J. 2008;27:384-393. (Pubitemid 351161657)
35. De Arcangelis V, Liu R, Soto D, Xiang Y. Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes. J Biol Chem. 2009;284:33824-33832.
36. Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B. Phosphodiesterase 4D is required for {beta}2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci USA. 2005.
37. Zaccolo M, Pozzan T. Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science. 2002; 295:1711-1715. (Pubitemid 34202906)
38. Soto D, De Arcangelis V, Zhang J, Xiang Y. Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circ Res. 2009; 104:770-779.
39. Balijepalli RC, Foell JD, Hall DD, Hell JW, Kamp TJ. Localization of cardiac L-type Ca(2 +) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation. Proc Natl Acad Sci USA. 2006;103:7500-7505. (Pubitemid 43727862)
40. Rybin VO, Xu X, Lisanti MP, Steinberg SF. Differential targeting of beta-adrenergic receptor subtypes and adenylyl cyclase to cardiomyo-cyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 2000;275:41447-41457. (Pubitemid 32054981)
41. Xiang Y, Rybin VO, Steinberg SF, Kobilka B. Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem. 2002;277:34280-34286.
42. Ostrom RS, Insel PA. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: Implications for molecular pharmacology. Br J Pharmacol. 2004;143:235-245. (Pubitemid 39315143)
43. Penela P, Ribas C, Mayor F Jr. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal. 2003;15:973-981. (Pubitemid 37130155)
44. Jurevicius J, Skeberdis VA, Fischmeister R. Role of cyclic nucleotide phosphodiesterase isoforms in camp compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes. J Physiol. 2003;551:239-252. (Pubitemid 37062925)
45. Xiao RP, Lakatta EG. S1-adrenoceptor stimulation and ß2- adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2 +, and Ca2+ current in single rat ventricular cells. Circ Res. 1993;73:286-300. (Pubitemid 23212109)
46. Chen-Izu Y, Xiao RP, Izu LT, Cheng H, Kuschel M, Spurgeon H, Lakatta EG. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2 +) channels. Biophys J. 2000;79:2547-2556.
47. Nikolaev VO, Bünemann M, Schmitteckert E, Lohse MJ, Engelhardt S. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ Res. 2006;99:1084-1091. (Pubitemid 44729932)
48. Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 2010;327:1653-1657.
49. Willoughby D, Cooper DM. Organization and Ca2 + regulation of adenylyl cyclases in cAMP microdomains. Physiol Rev. 2007;87:965-1010. (Pubitemid 47084674)
50. Dessauer CW. Adenylyl cyclase-A-kinase anchoring protein complexes: The next dimension in cAMP signaling. Mol Pharmacol. 2009; 76:935-941.
51. Defer N, Best-Belpomme M, Hanoune J. Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am J Physiol Renal Physiol. 2000;279:F400-F416.
52. Qin K, Sethi PR, Lambert NA. Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins. Faseb J. 2008;22:2920-2927.
53. Hein P, Bünemann M. Coupling mode of receptors and G proteins. Naunyn Schmiedebergs Arch Pharmacol. 2009;379:435-443.
54. Tian WN, Duzic E, Lanier SM, Deth RC. Determinants of alpha 2-adrenergic receptor activation of G proteins: Evidence for a pre-coupled receptor/G protein state. Mol Pharmacol. 1994;45:524-531.
55. Weitl N, Seifert R. Distinct interactions of human beta1-and beta2-adrenoceptors with isoproterenol, epinephrine, norepinephrine, and dopamine. J Pharmacol Exp Ther. 2008;327:760-769.
56. sa has properties of a constitutively active receptor. J Biol Chem. 1998;273:5109-5116. (Pubitemid 28108671)
57. Seifert R, Wenzel-Seifert K, Kobilka BK. GPCR-Galpha fusion proteins: Molecular analysis of receptor-g-protein coupling. Trends Pharmacol Sci. 1999;20:383-389. (Pubitemid 29421620)
58. Lin F, Wang H, Malbon CC. Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensiti-zation. J Biol Chem. 2000;275:19025-19034. (Pubitemid 30422869)
59. Cong M, Perry SJ, Lin FT, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, Lefkowitz RJ. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem. 2001;276:15192-15199.
60. Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, Lefkowitz RJ. The beta2-adrenergic receptor interacts with the Na+/H +-exchanger regulatory factor to control Na+/H+ exchange. Nature. 1998;392:626-630. (Pubitemid 28207723)
61. Cong M, Perry SJ, Hu LA, Hanson PI, Claing A, Lefkowitz RJ. Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. J Biol Chem. 2001;276:45145-45152.
62. Wang Y, Lauffer B, Von Zastrow M, Kobilka BK, Xiang Y. N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. Mol Pharmacol. 2007;72:429-439. (Pubitemid 47124123)
63. Hu LA, Tang Y, Miller WE, Cong M, Lau AG, Lefkowitz RJ, Hall RA. Beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. J Biol Chem. 2000; 275:38659-38666. (Pubitemid 32009197)
64. Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ. GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. J Biol Chem. 2003;278: 26295-26301. (Pubitemid 36835399)
65. Xu J, Paquet M, Lau AG, Wood JD, Ross CA, Hall RA. Beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. J Biol Chem. 2001;276:41310-41317.
66. Fujita A, Kurachi Y. SAP family proteins. Biochem Biophys Res Commun. 2000;269:1-6. (Pubitemid 30440244)
67. Gardner LA, Naren AP, Bahouth SW. Assembly of an SAP97-AKAP79-cAMP- dependent protein kinase scaffold at the type 1 PSD-95/DLG/ZO1 motif of the human beta(1)-adrenergic receptor generates a receptosome involved in receptor recycling and networking. J Biol Chem. 2007;282:5085-5099. (Pubitemid 47100997)
68. Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL, Scott JD. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron. 2000;27:107-119.
69. Willoughby D, Wong W, Schaack J, Scott JD, Cooper DM. An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. Embo J. 2006;25:2051-2061.
70. Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M. Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res. 2004;95:67-75. (Pubitemid 38931837)
71. Mongillo M, Tocchetti CG, Terrin A, Lissandron V, Cheung YF, Dostmann WR, Pozzan T, Kass DA, Paolocci N, Houslay MD, Zaccolo M. Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res. 2006;98:226-234.
72. Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem. 2007;76:481-511.
73. Miller CL, Yan C. Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications. J Cardiovasc Transl Res. 2010;3:507-515.
74. Richter W, Jin SL, Conti M. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue. Biochem J. 2005;388:803-811. (Pubitemid 40941566)
75. Richter W, Xie M, Scheitrum C, Krall J, Movsesian MA, Conti M. Conserved expression and functions of PDE4 in rodent and human heart. Basic Res Cardiol. 2011;106:249-262.
76. Patrucco E, Albergine MS, Santana LF, Beavo JA. Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes. J Mol Cell Cardiol. 2010;49:330-333.
77. De Arcangelis V, Soto D, Xiang Y. Phosphodiesterase 4 and phos-phatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor. Mol Pharmacol. 2008;74:1453-1462.
78. Bruss MD, Richter W, Horner K, Jin SL, Conti M. Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts. J Biol Chem. 2008;283:22430-22442.
79. Kerfant BG, Zhao D, Lorenzen-Schmidt I, Wilson LS, Cai S, Chen SR, Maurice DH, Backx PH. PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circ Res. 2007;101:400-408. (Pubitemid 47267708)
80. Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci USA. 2005;102:14771-14776. (Pubitemid 41457131)
81. Ding B, Abe J, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: Implication in heart failure. Circulation. 2005;111:2469-2476. (Pubitemid 40696135)
82. Conti M, Richter W, Mehats C, Livera G, Park JY, Jin C. Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling. J Biol Chem. 2003;278:5493-5496. (Pubitemid 36800786)
83. Perry SJ, Baillie GS, Kohout TA, McPhee I, Magiera MM, Ang KL, Miller WE, McLean AJ, Conti M, Houslay MD, Lefkowitz RJ. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science. 2002;298:834-836. (Pubitemid 35231537)
84. Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD. Beta-arrestin-mediated pde4 camp phosphodiesterase recruitment regulates beta-adrenoceptor switching from gs to gi. Proc Natl Acad Sci USA. 2003;100:940-945. (Pubitemid 36183934)
85. Halls ML, Cooper DM. Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex. Embo J. 2010;29:2772-2787.
86. Hein P, Rochais F, Hoffmann C, Dorsch S, Nikolaev VO, Engelhardt S, Berlot CH, Lohse MJ, Bünemann M. Gs activation is time-limiting in initiating receptor-mediated signaling. J Biol Chem. 2006;281: 33345-33351. (Pubitemid 46036716)
87. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem. 2001;276:42063-42069.
88. Corbin JD, Keely SL. Characterization and regulation of heart adenosine 3':5'-monophosphate-dependent protein kinase isozymes. J Biol Chem. 1977;252:910-918. (Pubitemid 8041882)
89. Davare MA, Avdonin V, Hall DD, Peden EM, Burette A, Weinberg RJ, Horne MC, Hoshi T, Hell JW. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science. 2001;293: 98-101. (Pubitemid 32625503)
90. Naren AP, Cobb B, Li C, Roy K, Nelson D, Heda GD, Liao J, Kirk KL, Sorscher EJ, Hanrahan J, Clancy JP. A macromolecular complex of beta 2 adrenergic receptor, cftr, and ezrin/radixin/moesin-binding phospho-protein 50 is regulated by pka. Proc Natl Acad Sci USA. 2003;100: 342-346. (Pubitemid 36078076)
91. Barbuti A, DiFrancesco D. Control of cardiac rate by "funny" channels in health and disease. Ann N Y Acad Sci. 2008;1123:213-223. (Pubitemid 351431319)
92. Shenoy SK, Lefkowitz RJ. Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem J. 2003;375:503-515. (Pubitemid 37433499)
93. Ferguson SS, Barak LS, Zhang J, Caron MG. G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. Can J Physiol Pharmacol. 1996;74:1095-1110. (Pubitemid 27047505)
94. Cassel D, Selinger Z. Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes. Biochim Biophys Acta. 1976;452:538-551.
95. Brandt DR, Ross EM. Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2 + studied in reconstituted receptor-gs vesicles. J Biol Chem. 1986;261:1656-1664. (Pubitemid 17204998)
96. Shakur Y, Holst LS, Landstrom TR, Movsesian M, Degerman E, Man-ganiello V. Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog Nucleic Acid Res Mol Biol. 2001;66: 241-277.
97. MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD. Long PDE4 camp specific phosphodiesterases are activated by protein kinase a-mediated phosphorylation of a single serine residue in upstream conserved region 1 (UCR1). Br J Pharmacol. 2002;136:421-433. (Pubitemid 34620523)
98. Xiang Y, Devic E, Kobilka B. The PDZ binding motif of the beta 1 adrenergic receptor modulates receptor trafficking and signaling in cardiac myocytes. J Biol Chem. 2002;277:33783-33790.
99. Gage RM, Kim KA, Cao TT, von Zastrow M. A transplantable sorting signal that is sufficient to mediate rapid recycling of G protein-coupled receptors. J Biol Chem. 2001;276:44712-44720.
100. Yudowski GA, Puthenveedu MA, Henry AG, von Zastrow M. Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway. Mol Biol Cell. 2009;20:2774-2784.
101. Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y. Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes. J Biol Chem. 2009;284:32279-32287.
102. Tran TM, Friedman J, Qunaibi E, Baameur F, Moore RH, Clark RB. Characterization of agonist stimulation of camp-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Mol Pharmacol. 2004;65:196-206. (Pubitemid 38113900)
103. Bolger GB, Baillie GS, Li X, Lynch MJ, Herzyk P, Mohamed A, Mitchell LH, McCahill A, Hundsrucker C, Klussmann E, Adams DR, Houslay MD. Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J. 2006;398:23-36. (Pubitemid 44231298)
104. Li X, Baillie GS, Houslay MD. Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem. 2009;284:16170-16182.
105. Li X, Vadrevu S, Dunlop A, Day J, Advant N, Troeger J, Klussmann E, Jaffrey E, Hay RT, Adams DR, Houslay MD, Baillie GS. Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochem J. 2010;428:55-65.
106. Hulme JT, Lin TW, Westenbroek RE, Scheuer T, Catterall WA. Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with a kinase-anchoring protein 15. Proc Natl Acad Sci USA. 2003;100:13093-13098. (Pubitemid 37340031)
107. Hulme JT, Westenbroek RE, Scheuer T, Catterall WA. Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation. Proc Natl Acad Sci USA. 2006;103:16574-16579. (Pubitemid 44715237)
108. Gray PC, Johnson BD, Westenbroek RE, Hays LG, Yates JR III, Scheuer T, Catterall WA, Murphy BJ. Primary structure and function of an A kinase anchoring protein associated with calcium channels. Neuron. 1998;20:1017-1026. (Pubitemid 28247406)
109. Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E. AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep. 2007;8:1061-1067. (Pubitemid 350042342)
110. Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101:365-376.
111. Cuello F, Bardswell SC, Haworth RS, Yin X, Lutz S, Wieland T, Mayr M, Kentish JC, Avkiran M. Protein kinase D selectively targets cardiac troponin i and regulates myofilament Ca2+ sensitivity in ventricular myocytes. Circulation research. 2007;100:864-873. (Pubitemid 46555692)
112. Haworth RS, Roberts NA, Cuello F, Avkiran M. Regulation of protein kinase D activity in adult myocardium: Novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A. J Mol Cell Cardiol. 2007;43:686-695. (Pubitemid 350166389)
113. Pare GC, Bauman AL, McHenry M, Michel JJ, Dodge-Kafka KL, Kapiloff MS. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. J Cell Sci. 2005;118:5637-5646. (Pubitemid 43079302)
114. Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, Scott JD. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature. 2005;437:574-578. (Pubitemid 41613557)
115. Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN, McKinsey TA. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol. 2004;24:8374-8385. (Pubitemid 39245060)
116. De Arcangelis V, Coletti D, Conti M, Lagarde M, Molinaro M, Adamo S, Nemoz G, Naro F. IGFi-induced differentiation of l6 myogenic cells requires the activity of cAMP-phosphodiesterase. Mol Biol Cell. 2003; 14:1392-1404. (Pubitemid 36547409)
117. Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci USA. 2006; 103:12923-12928. (Pubitemid 44298662)
118. Kapiloff MS, Piggott LA, Sadana R, Li J, Heredia LA, Henson E, Efendiev R, Dessauer CW. An adenylyl cyclase-makapbeta signaling complex regulates cAMP levels in cardiac myocytes. J Biol Chem. 2009;284:23540-23546.
119. Liu S, Zhang J, Xiang YK. FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyo-cytes. Biochem Biophys Res Commun. 2011;404:581-586.
120. Dodge KL, Khouangsathiene S, Kapiloff MS, Mouton R, Hill EV, Houslay MD, Langeberg LK, Scott JD. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. Embo J. 2001;20:1921-1930. (Pubitemid 32397394)
121. Yin X, Cuello F, Mayr U, Hao Z, Hornshaw M, Ehler E, Avkiran M, Mayr M. Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. Mol Cell Proteomics. 2010;9:497-509.
122. Dodge-Kafka KL, Bauman A, Mayer N, Henson E, Heredia L, Ahn J, McAvoy T, Nairn AC, Kapiloff MS. Camp-stimulated protein phos-phatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3. J Biol Chem. 2010; 285:11078-11086.
123. Marks AR, Reiken S, Marx SO. Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor? Circulation. 2002;105:272-275. (Pubitemid 34106169)
124. Messer AE, Jacques AM, Marston SB. Troponin phosphorylation and regulatory function in human heart muscle: Dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure. J Mol Cell Cardiol. 2007;42:247-259. (Pubitemid 44970468)
125. Rapundalo ST. Cardiac protein phosphorylation: functional and patho-physiological correlates. Cardiovasc Res. 1998;38:559-588. (Pubitemid 28319868)
126. Devic E, Xiang Y, Gould D, Kobilka B. Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Mol Pharmacol. 2001;60:577-583. (Pubitemid 32781566)
127. Rohrer DK, Desai KH, Jasper JR, Stevens ME, Regula DP, Jr., Barsh GS, Bernstein D, Kobilka BK. Targeted disruption of the mouse beta1-adrenergic receptor gene: Developmental and cardiovascular effects. Proc Natl Acad Sci USA. 1996;93:7375-7380. (Pubitemid 26243558)
128. Rohrer DK, Chruscinski A, Schauble EH, Bernstein D, Kobilka BK. Cardiovascular and metabolic alterations in mice lacking both beta1-and beta2-adrenergic receptors. J Biol Chem. 1999;274:16701-16708.
129. Chruscinski AJ, Rohrer DK, Schauble E, Desai KH, Bernstein D, Kobilka BK. Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem. 1999;274:16694-16700.
130. Xiang Y, Kobilka B. The PDZ-binding motif of the beta2-adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes. Proc Natl Acad Sci USA. 2003;100:10776-10781. (Pubitemid 37140104)
131. Wang Y, De Arcangelis V, Gao X, Ramani B, Jung YS, Xiang Y. Norepinephrine-and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. J Biol Chem. 2008;283:1799-1807.
132. Skeberdis VA, Jurevicius J, Fischmeister R. Beta-2 adrenergic activation of L-type Ca+ + current in cardiac myocytes. J Pharmacol Exp Ther. 1997;283:452-461. (Pubitemid 27514598)
133. Zhou YY, Cheng H, Bogdanov KY, Hohl C, Altschuld R, Lakatta EG, Xiao RP. Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling. Am J Physiol. 1997;273:H1611-H1618.
134. Kuschel M, Zhou YY, Cheng H, Zhang SJ, Chen Y, Lakatta EG, Xiao RP. G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling. J Biol Chem. 1999;274:22048-22052.
135. Gauthier C, Langin D, Balligand JL. Beta3-adrenoceptors in the cardiovascular system. Trends Pharmacol Sci. 2000;21:426-431.
136. Münunzel T, Gori T. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009;54:1491-1499.
137. Ma H, Green RD. Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists. Mol Pharmacol. 1992;42: 831-837. (Pubitemid 23021487)
138. Warrier S, Belevych AE, Ruse M, Eckert RL, Zaccolo M, Pozzan T, Harvey RD. Beta-adrenergic-and muscarinic receptor-induced changes in cAMp activity in adult cardiac myocytes detected with FRET-based biosensor. Am J Physiol Cell Physiol. 2005;289:C455-C461. (Pubitemid 41008892)
139. Iancu RV, Ramamurthy G, Harvey RD. Spatial and temporal aspects of cAMP signalling in cardiac myocytes. Clin Exp Pharmacol Physiol. 2008;35:1343-1348.
140. Abi-Gerges A, Richter W, Lefebvre F, Mateo P, Varin A, Heymes C, Samuel JL, Lugnier C, Conti M, Fischmeister R, Vandecasteele G. Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. Circ Res. 2009;105:784-792.
141. Salloum FN, Abbate A, Das A, Houser JE, Mudrick CA, Qureshi IZ, Hoke NN, Roy SK, Brown WR, Prabhakar S, Kukreja RC. Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice. Am J Physiol Heart Circ Physiol. 2008;294: H1398-H1406 (Pubitemid 351468739)
142. Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED. Phosphodiesterase type 5 is highly expressed in the hyper-trophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation. 2007;116:238-248. (Pubitemid 47196559)
143. Pokreisz P, Vandenwijngaert S, Bito V, Van den Bergh A, Lenaerts I, Busch C, Marsboom G, Gheysens O, Vermeersch P, Biesmans L, Liu X, Gillijns H, Pellens M, Van Lommel A, Buys E, Schoonjans L, Van-haecke J, Verbeken E, Sipido K, Herijgers P, Bloch KD, Janssens SP. Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice. Circulation. 2009;119:408-416.
144. Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe J, Yan C. Role of Ca2 +/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res. 2009; 105:956-964.
145. Yanaka N, Kurosawa Y, Minami K, Kawai E, Omori K. cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles. Biosci Biotechnol Biochem. 2003;67:973-979. (Pubitemid 39251854)
146. Mokni W, Keravis T, Etienne-Selloum N, Walter A, Kane MO, Schini-Kerth VB, Lugnier C. Concerted regulation of cgmp and camp phosphodiesterases in early cardiac hypertrophy induced by angiotensin II. PLoS One. 2010;5:e14227.