Chronic hyperinsulinemia causes selective insulin resistance and down-regulates uncoupling protein 3 (ucp3) through the activation of sterol regulatory element-binding protein (srebp)-1 transcription factor in the mouse heart

Journal of Biological Chemistry

Volumn 290, Issue 52, 2015, Pages 30947-30961

  Harmancey, Romain ^a,b   Haight, Derek L ^a   Watts, Kayla A ^b   Taegtmeyer, Heinrich ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BINS; CARDIOLOGY; CHEMICAL ACTIVATION; CYTOLOGY; DIAGNOSIS; ENZYME ACTIVITY; INSULIN; INTERFERENCE SUPPRESSION; MAMMALS; PROTEINS;

FUNCTIONAL RECOVERY; MITOGEN ACTIVATED PROTEIN KINASE; MYOCARDIAL INFARCTION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; STEROL REGULATORY ELEMENT-BINDING PROTEINS; STEROL REGULATORY ELEMENTS;

HEART;

4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPOXY]PHENOXY]ACETIC ACID; ACYL COENZYME A DESATURASE 1; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; HUMAN INSULIN; ISOPHANE INSULIN; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUSCLE RING FINGER 1 PROTEIN; NICOTINIC ACID; PIRINIXIC ACID; PROTEIN BNIP3; PROTEIN KINASE B; PYRUVATE DEHYDROGENASE KINASE 4; ROSIGLITAZONE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR FOXO; UNCOUPLING PROTEIN 3; ION CHANNEL; MITOCHONDRIAL PROTEIN; SREBF1 PROTEIN, MOUSE; UCP3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CHRONIC DISEASE; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; DRUG DOSE INCREASE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE CELL; HYPERINSULINEMIA; IMMUNOBLOTTING; INSULIN RESISTANCE; INTRON; LIPOGENESIS; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SITE DIRECTED MUTAGENESIS; ANIMAL; BIOSYNTHESIS; CARDIAC MUSCLE; CELL CULTURE; DNA RESPONSIVE ELEMENT; GENETICS; HYPERINSULINISM; METABOLISM; PATHOLOGY;

ANIMALS; CELLS, CULTURED; CHRONIC DISEASE; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; HYPERINSULINISM; ION CHANNELS; MALE; MICE; MITOCHONDRIAL PROTEINS; MYOCARDIAL INFARCTION; MYOCARDIUM; RESPONSE ELEMENTS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCOUPLING PROTEIN 3;

EID: 84951807748     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.673988     Document Type: Article

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