Endocytosis machinery is required for β1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes

Cardiovascular Research

Volumn 78, Issue 1, 2008, Pages 36-44

  Morisco, Carmine ^a,b   Marrone, Chiara ^a,b   Galeotti, Jonathan ^a   Shao, Dan ^a   Vatner, Dorothy E ^a   Vatner, Stephen F ^a   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cell culture; Myocytes; Protein kinases; Protein phosphorylation

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BETA 1 ADRENERGIC RECEPTOR; BETA ARRESTIN; CONCANAVALIN A; DYNAMIN; ISOPRENALINE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA CONTENT; ENDOCYTOSIS; HEART HYPERTROPHY; IMMUNOBLOTTING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANIMALS, NEWBORN; ARRESTINS; ATRIAL NATRIURETIC FACTOR; CARDIOMEGALY; CELL SIZE; CELLS, CULTURED; CONCANAVALIN A; DYNAMINS; ENDOCYTOSIS; ENZYME ACTIVATION; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; ISOPROTERENOL; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA-1; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 41149180568     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvn008     Document Type: Article

References (34)

1. Vatner SF, Vatner DE, Homcy CJ. Beta-adrenergic receptor signaling: an acute compensatory adjustment - inappropriate for the chronic stress of heart failure? Insights from Gsalpha overexpression and other genetically engineered animal models. Circ Res 2000;86:502-506.
2. Port JD, Bristow MR. Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. J Mol Cell Cardiol 2001;33:887-905.
3. Limbird LE, Vaughan DE. Augmenting beta receptors in the heart: short-term gains offset by long-term pains? Proc Natl Acad Sci USA 1999;96:7125-7127.
4. Morisco C, Zebrowski DC, Vatner DE, Vatner SF, Sadoshima J. Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. J Mol Cell Cardiol 2001;33:561-573.
5. Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA 1999;96:7059-7064.
6. Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR et al. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science 1994;264:582-586.
7. Dorn GW II, Tepe NM, Lorenz JN, Koch WJ, Liggett SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proc Natl Acad Sci USA 1999;96:6400-6405.
8. Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y et al. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. J Clin Invest 2007;117:1335-1343.
9. Bristow MR. Beta-adrenergic receptor blockade in chronic heart failure. Circulation 2000;101:558-569.
10. Xiao RP. Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins. Sci STKE 2001;2001:RE15.
11. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annu Rev Physiol 2007;69:483-510.
12. Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF, Sadoshima J. The Akt-glycogen synthase kinase 3 beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem 2000;275:14466-14475.
13. Rocha-Singh KJ, Hines DK, Honbo NY, Karliner JS. Concanavalin A amplifies both beta-adrenergic and muscarinic cholinergic receptor-adenylate cyclase-linked pathways in cardiac myocytes. J Clin Invest 1991;88:760-766.
14. Koch WJ, Hawes BE, Inglese J, Luttrell LM, Lefkowitz RJ. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J Biol Chem 1994;269:6193-6197.
15. Krupnick JG, Santini F, Gagnon AW, Keen JH, Benovic JL. Modulation of the arrestin-clathrin interaction in cells. Characterization of beta-arrestin dominant-negative mutants. J Biol Chem 1997;272:32507-32512.
16. Kao AW, Ceresa BP, Santeler SR, Pessin JE. Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling. J Biol Chem 1998;273:25450- 25457.
17. Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ. Beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. J Biol Chem 2000;275:11312-11319.
18. Tong H, Rockman HA, Koch WJ, Steenbergen C, Murphy E. G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. Circ Res 2004;94:1133-1141.
19. Tachibana H, Naga Prasad SV, Lefkowitz RJ, Koch WJ, Rockman HA. Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation 2005;111:591-597.
20. Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA et al. Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J Biol Chem 1997;272:31051-31057.
21. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA et al. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science 1995;268:1350-1353.
22. Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF et al. Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 2002;22:2799-2809.
23. Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC et al. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell 1999;96:677-687.
24. Naga Prasad SV, Barak LS, Rapacciuolo A, Caron MG, Rockman HA. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. J Biol Chem 2001;276:18953-18959.
25. Pinson A, Schluter KD, Zhou XJ, Schwartz P, Kessler-Icekson G, Piper HM. Alpha- and beta-adrenergic stimulation of protein synthesis in cultured adult ventricular cardiomyocytes. J Mol Cell Cardiol 1993;25:477-490.
26. Suzuki T, Nguyen CT, Nantel F, Bonin H, Valiquette M, Frielle T et al. Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts. Mol Pharmacol 1992;41:542-548.
27. Oakley RH, Laporte SA, Holt JA, Caron MG, Barak LS. Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem 2000;275:17201-17210.
28. Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J Biol Chem 1995;270:17953-17961.
29. Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA et al. Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Proc Natl Acad Sci USA 1999;96:12559-12564.
30. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem 2001;276:42063-42069.
31. Rybin VO, Xu X, Lisanti MP, Steinberg SF. Differential targeting of beta-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem 2000;275:41447-41457.
32. Pitcher JA, Touhara K, Payne ES, Lefkowitz RJ. Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. J Biol Chem 1995;270:11707-11710.
33. Stephens L, Smrcka A, Cooke FT, Jackson TR, Sternweis PC, Hawkins PT. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell 1994;77:83-93.
34. Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J Jr et al. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci USA 1998;95:7000-7005.