Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway

Pharmacological Research

Volumn 104, Issue , 2016, Pages 115-123

  Wu, Mei Ping ^a,b   Zhang, Yi Shuai ^b   Zhou, Qian Mei ^a   Xiong, Jian ^b,c   Dong, Yao Rong ^a   Yan, Chen ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Apoptosis; Beta2 adrenergic receptor; Cardiomyocyte; Higenamine; Ischemia reperfusion

Indexed keywords

ALKALOID; BETA 2 ADRENERGIC RECEPTOR; CARDIOTONIC AGENT; CASPASE 3; HIGENAMINE; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL; APOPTOSIS; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL CULTURE; DRUG EFFECTS; MALE; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ALKALOIDS; ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CASPASE 3; CELLS, CULTURED; HYDROGEN PEROXIDE; MALE; MICE, INBRED C57BL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; TETRAHYDROISOQUINOLINES;

EID: 84953250455     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.12.032     Document Type: Article

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