메뉴 건너뛰기




Volumn 9, Issue 3, 2012, Pages 147-157

Reverse remodeling in heart failure-mechanisms and therapeutic opportunities

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM BINDING PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; G PROTEIN COUPLED RECEPTOR KINASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HYDRALAZINE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN S100A1; RUBOXISTAURIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; SOTRASTAURIN; SPIRONOLACTONE; THYMOSIN BETA4; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84857643399     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2011.172     Document Type: Review
Times cited : (194)

References (143)
  • 1
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2010 update: A report from the american heart association
    • Lloyd-Jones, D. et al. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121, e46-e215 (2010).
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1
  • 2
    • 0034162004 scopus 로고    scopus 로고
    • Cardiac remodeling-concepts and clinical implications: A consensus paper from an International Forum on Cardiac Remodeling
    • DOI 10.1016/S0735-1097(99)00630-0, PII S0735109799006300
    • Cohn, J. N., Ferrari, R. & Sharpe, N. Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J. Am. Coll. Cardiol. 35, 569-582 (2000). (Pubitemid 30167013)
    • (2000) Journal of the American College of Cardiology , vol.35 , Issue.3 , pp. 569-582
    • Cohn, J.N.1    Ferrari, R.2    Sharpe, N.3
  • 3
    • 31444448021 scopus 로고    scopus 로고
    • Controversies in ventricular remodelling
    • DOI 10.1016/S0140-6736(06)68074-4, PII S0140673606680744
    • Opie, L. H., Commerford, P. J., Gersh, B. J. & Pfeffer, M. A. Controversies in ventricular remodelling. Lancet 367, 356-367 (2006). (Pubitemid 43151469)
    • (2006) Lancet , vol.367 , Issue.9507 , pp. 356-367
    • Opie, L.H.1    Commerford, P.J.2    Gersh, B.J.3    Pfeffer, M.A.4
  • 4
    • 78650710691 scopus 로고    scopus 로고
    • Molecular pathways underlying cardiac remodeling during pathophysiological stimulation
    • Kehat, I. & Molkentin, J. D. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation 122, 2727-2735 (2010).
    • (2010) Circulation , vol.122 , pp. 2727-2735
    • Kehat, I.1    Molkentin, J.D.2
  • 5
    • 34249275677 scopus 로고    scopus 로고
    • Reversing chronic remodeling in heart failure
    • DOI 10.1586/14779072.5.3.585
    • Mudd, J. O. & Kass, D. A. Reversing chronic remodeling in heart failure. Expert Rev. Cardiovasc. Ther. 5, 585-598 (2007). (Pubitemid 46805584)
    • (2007) Expert Review of Cardiovascular Therapy , vol.5 , Issue.3 , pp. 585-598
    • Mudd, J.O.1    Kass, D.A.2
  • 6
    • 0021968215 scopus 로고
    • Influence of chronic captopril therapy on the infarcted left ventricle of the rat
    • Pfeffer, J. M., Pfeffer, M. A. & Braunwald, E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ. Res. 57, 84-95 (1985). (Pubitemid 15238844)
    • (1985) Circulation Research , vol.57 , Issue.1 , pp. 84-95
    • Pfeffer, J.M.1    Pfeffer, M.A.2    Braunwald, E.3
  • 7
    • 0018744646 scopus 로고
    • Left ventricular radius to wall thickness ratio
    • DOI 10.1016/0002-9149(79)90152-8
    • Gaasch, W. H. Left ventricular radius to wall thickness ratio. Am. J. Cardiol. 43, 1189-1194 (1979). (Pubitemid 9191003)
    • (1979) American Journal of Cardiology , vol.43 , Issue.6 , pp. 1189-1194
    • Gaasch, W.H.1
  • 8
    • 0036143851 scopus 로고    scopus 로고
    • Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress
    • DOI 10.1161/hc0102.101365
    • Esposito, G. et al. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105, 85-92 (2002). (Pubitemid 34049147)
    • (2002) Circulation , vol.105 , Issue.1 , pp. 85-92
    • Esposito, G.1    Rapacciuolo, A.2    Naga Prasad, S.V.3    Takaoka, H.4    Thomas, S.A.5    Koch, W.J.6    Rockman, H.A.7
  • 9
    • 33745185351 scopus 로고    scopus 로고
    • Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction
    • Perrino, C. et al. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J. Clin. Invest. 116, 1547-1560 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 1547-1560
    • Perrino, C.1
  • 11
    • 79251556005 scopus 로고    scopus 로고
    • The progression of hypertensive heart disease
    • Drazner, M. H. The progression of hypertensive heart disease. Circulation 123, 327-334 (2011).
    • (2011) Circulation , vol.123 , pp. 327-334
    • Drazner, M.H.1
  • 12
    • 80052783805 scopus 로고    scopus 로고
    • Progression from normal to reduced left ventricular ejection fraction in patients with concentric left ventricular hypertrophy after long-term follow-up
    • Krishnamoorthy, A. et al. Progression from normal to reduced left ventricular ejection fraction in patients with concentric left ventricular hypertrophy after long-term follow-up. Am. J. Cardiol. 108, 997-1001 (2011).
    • (2011) Am. J. Cardiol. , vol.108 , pp. 997-1001
    • Krishnamoorthy, A.1
  • 13
    • 39749168495 scopus 로고    scopus 로고
    • Tackling heart failure in the twenty-first century
    • DOI 10.1038/nature06798, PII NATURE06798
    • Mudd, J. O. & Kass, D. A. Tackling heart failure in the twenty-first century. Nature 451, 919-928 (2008). (Pubitemid 351301747)
    • (2008) Nature , vol.451 , Issue.7181 , pp. 919-928
    • Mudd, J.O.1    Kass, D.A.2
  • 14
    • 0028945136 scopus 로고
    • Reverse remodeling from cardiomyoplasty in human heart failure external constraint versus active assist
    • Kass, D. A. et al. Reverse remodeling from cardiomyoplasty in human heart failure. External constraint versus active assist. Circulation 91, 2314-2318 (1995).
    • (1995) Circulation , vol.91 , pp. 2314-2318
    • Kass, D.A.1
  • 16
    • 0032537621 scopus 로고    scopus 로고
    • Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure
    • Dipla, K., Mattiello, J. A., Jeevanandam, V., Houser, S. R. & Margulies, K. B. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation 97, 2316-2322 (1998). (Pubitemid 28280385)
    • (1998) Circulation , vol.97 , Issue.23 , pp. 2316-2322
    • Dipla, K.1    Mattiello, J.A.2    Jeevanandam, V.3    Houser, S.R.4    Margulies, K.B.5
  • 17
    • 0032213728 scopus 로고    scopus 로고
    • 1 and endothelin-1 from fibroblasts
    • DOI 10.1016/S0008-6363(98)00121-7, PII S0008636398001217
    • Gray, M. O., Long, C. S., Kalinyak, J. E., Li, H. T. & Karliner, J. S. Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF β1 and endothelin 1 from fibroblasts. Cardiovasc. Res. 40, 352-363 (1998). (Pubitemid 28506046)
    • (1998) Cardiovascular Research , vol.40 , Issue.2 , pp. 352-363
    • Gray, M.O.1    Long, C.S.2    Kalinyak, J.E.3    Li, H.-T.4    Karliner, J.S.5
  • 18
    • 0025759178 scopus 로고
    • Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin converting enzyme inhibition
    • Sharpe, N. et al. Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin converting enzyme inhibition. Lancet 337, 872-876 (1991).
    • (1991) Lancet , vol.337 , pp. 872-876
    • Sharpe, N.1
  • 19
    • 0041909380 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: The CHARM-alternative trial
    • DOI 10.1016/S0140-6736(03)14284-5
    • Granger, C. B. et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin converting enzyme inhibitors: the CHARM-Alternative trial. Lancet 362, 772-776 (2003). (Pubitemid 37093917)
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 772-776
    • Granger, C.B.1    McMurray, J.J.V.2    Yusuf, S.3    Held, P.4    Michelson, E.L.5    Olofsson, B.6    Ostergren, J.7    Pfeffer, M.A.8    Swedberg, K.9
  • 21
    • 79954579275 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism
    • Habashi, J. P. et al. Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science 332, 361-365 (2011).
    • (2011) Science , vol.332 , pp. 361-365
    • Habashi, J.P.1
  • 22
    • 79959370726 scopus 로고    scopus 로고
    • Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure
    • Avila, M. D., Morgan, J. P. & Yan, X. Genetically modified mouse models used for studying the role of the AT2 receptor in cardiac hypertrophy and heart failure. J. Biomed. Biotechnol. 2011, 141039 (2011).
    • (2011) J. Biomed. Biotechnol. 2011 , pp. 141039
    • Avila, M.D.1    Morgan, J.P.2    Yan, X.3
  • 24
    • 0034890764 scopus 로고    scopus 로고
    • Cardiac nitric oxide production due to angiotensin-converting enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilated cardiomyopathy
    • DOI 10.1016/S0735-1097(01)01404-8, PII S0735109701014048
    • Wittstein, I. S. et al. Cardiac nitric oxide production due to angiotensin-converting enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilatedcardiomyopathy. J. Am. Coll. Cardiol. 38, 429-435 (2001). (Pubitemid 32721771)
    • (2001) Journal of the American College of Cardiology , vol.38 , Issue.2 , pp. 429-435
    • Wittstein, I.S.1    Kass, D.A.2    Pak, P.H.3    Maughan W.Lowell4    Fetics, B.5    Hare, J.M.6
  • 25
    • 2942518221 scopus 로고    scopus 로고
    • Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: A substudy of the Heart Outcomes Prevention Evaluation (HOPE) trial
    • DOI 10.1016/j.jacc.2003.10.073, PII S0735109704005844
    • Lonn, E. et al. Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction: a substudy of the Heart Outcomes Prevention Evaluation (HOPE) Trial. J. Am. Coll. Cardiol. 43, 2200-2206 (2004). (Pubitemid 38757585)
    • (2004) Journal of the American College of Cardiology , vol.43 , Issue.12 , pp. 2200-2206
    • Lonn, E.1    Shaikholeslami, R.2    Yi, Q.3    Bosch, J.4    Sullivan, B.5    Tanser, P.6    Magi, A.7    Yusuf, S.8
  • 27
    • 0028275578 scopus 로고
    • Collagen metabolism in cultured adult rat cardiac fibroblasts: Response to angiotensin II and aldosterone
    • DOI 10.1006/jmcc.1994.1098
    • Brilla, C. G., Zhou, G., Matsubara, L. & Weber, K. T. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J. Mol. Cell Cardiol. 26, 809-820 (1994). (Pubitemid 24223231)
    • (1994) Journal of Molecular and Cellular Cardiology , vol.26 , Issue.7 , pp. 809-820
    • Brilla, C.G.1    Zhou, G.2    Matsubara, L.3    Weber, K.T.4
  • 28
    • 18244379073 scopus 로고    scopus 로고
    • Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure
    • Yoshida, M. et al. Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure. Congest. Heart Fail. 11, 12-16 (2005).
    • (2005) Congest. Heart Fail. , vol.11 , pp. 12-16
    • Yoshida, M.1
  • 29
    • 0242543981 scopus 로고    scopus 로고
    • Additive Improvement of Left Ventricular Remodeling and Neurohormonal Activation by Aldosterone Receptor Blockade with Eplerenone and ACE Inhibition in Rats with Myocardial Infarction
    • DOI 10.1016/j.jacc.2003.05.003
    • Fraccarollo, D. et al. Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction. J. Am. Coll. Cardiol. 42, 1666-1673 (2003). (Pubitemid 37378451)
    • (2003) Journal of the American College of Cardiology , vol.42 , Issue.9 , pp. 1666-1673
    • Fraccarollo, D.1    Galuppo, P.2    Hildemann, S.3    Christ, M.4    Ertl, G.5    Bauersachs, J.6
  • 30
    • 18244387434 scopus 로고    scopus 로고
    • Aldosterone receptor blockade prevents the transition to cardiac pump dysfunction induced by β-adrenoreceptor activation
    • DOI 10.1161/01.HYP.0000164567.62172.c5
    • Veliotes, D. G. et al. Aldosterone receptor blockade prevents the transition to cardiac pump dysfunction induced by β-adrenoreceptor activation. Hypertension 45, 914-920 (2005). (Pubitemid 40628937)
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 914-920
    • Veliotes, D.G.A.1    Woodiwiss, A.J.2    Deftereos, D.A.J.3    Gray, D.4    Osadchii, O.5    Norton, G.R.6
  • 31
    • 0038526268 scopus 로고    scopus 로고
    • Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction
    • DOI 10.1161/01.CIR.0000068340.96506.0F
    • Hayashi, M. et al. Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardial infarction. Circulation 107, 2559-2565 (2003). (Pubitemid 36628936)
    • (2003) Circulation , vol.107 , Issue.20 , pp. 2559-2565
    • Hayashi, M.1    Tsutamoto, T.2    Wada, A.3    Tsutsui, T.4    Ishii, C.5    Ohno, K.6    Fujii, M.7    Taniguchi, A.8    Hamatani, T.9    Nozato, Y.10    Kataoka, K.11    Morigami, N.12    Ohnishi, M.13    Kinoshita, M.14    Horie, M.15
  • 32
    • 77954739690 scopus 로고    scopus 로고
    • Randomized double-blind multicenter placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild to moderate heart failure and left ventricular systolic dysfunction
    • Udelson, J. E. et al. Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild to moderate heart failure and left ventricular systolic dysfunction. Circ. Heart Fail. 3, 347-353 (2010).
    • (2010) Circ. Heart Fail. , vol.3 , pp. 347-353
    • Udelson, J.E.1
  • 34
    • 79955463305 scopus 로고    scopus 로고
    • Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
    • Solomon, S. D. et al. Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. Eur. Heart J. 32, 1227-1234 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 1227-1234
    • Solomon, S.D.1
  • 35
    • 0026558346 scopus 로고
    • Adrenergic effects on the biology of the adult mammalian cardiocyte
    • Mann, D. L., Kent, R. L., Parsons, B. & Cooper, G. 4th. Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 85, 790-804 (1992).
    • (1992) Circulation , vol.85 , pp. 790-804
    • Mann, D.L.1    Kent, R.L.2    Parsons, B.3    Cooper, I.V.G.4
  • 38
    • 0038662725 scopus 로고    scopus 로고
    • β-Blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure
    • DOI 10.1161/01.CIR.0000068316.53218.49
    • Reiken, S. et al. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation 107, 2459-2466 (2003). (Pubitemid 36605229)
    • (2003) Circulation , vol.107 , Issue.19 , pp. 2459-2466
    • Reiken, S.1    Wehrens, X.H.T.2    Vest, J.A.3    Barbone, A.4    Klotz, S.5    Mancini, D.6    Burkhoff, D.7    Marks, A.R.8
  • 39
    • 0342437444 scopus 로고    scopus 로고
    • Improvement of postreceptor events by metoprolol treatment in patients with chronic heart failure
    • DOI 10.1016/S0735-1097(97)00248-9, PII S0735109797002489
    • Bohm, M., Deutsch, H. J., Hartmann, D., Rosee, K. L. & Stablein, A. Improvement of postreceptor events by metoprolol treatment in patients with chronic heart failure. J. Am. Coll. Cardiol. 30, 992-996 (1997). (Pubitemid 27435892)
    • (1997) Journal of the American College of Cardiology , vol.30 , Issue.4 , pp. 992-996
    • Bohm, M.1    Deutsch, H.J.2    Hartmann, D.3    La Rosee, K.4    Stablein, A.5
  • 40
    • 0034711128 scopus 로고    scopus 로고
    • The effects of β1-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study
    • Beanlands, R. S. et al. The effects of β1-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: a double-blind, placebo-controlled, positron-emission tomography study. Circulation 102, 2070-2075 (2000).
    • (2000) Circulation , vol.102 , pp. 2070-2075
    • Beanlands, R.S.1
  • 42
    • 0033133519 scopus 로고    scopus 로고
    • Mapping of regional myocardial strain and work during ventricular pacing: Experimental study using magnetic resonance imaging tagging
    • Prinzen, F. W., Hunter, W. C., Wyman, B. T. & McVeigh, E. R. Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging. J. Am. Coll. Cardiol. 33, 1735-1742 (1999).
    • (1999) J. Am. Coll. Cardiol. , vol.33 , pp. 1735-1742
    • Prinzen, F.W.1    Hunter, W.C.2    Wyman, B.T.3    McVeigh, E.R.4
  • 43
    • 33746048385 scopus 로고    scopus 로고
    • Pathobiology of Left Ventricular Dyssynchrony and Resynchronization
    • DOI 10.1016/j.pcad.2006.05.001, PII S0033062006000648
    • Spragg, D. D. & Kass, D. A. Pathobiology of left ventricular dyssynchrony and resynchronization. Prog. Cardiovasc. Dis. 49, 26-41 (2006). (Pubitemid 44080800)
    • (2006) Progress in Cardiovascular Diseases , vol.49 , Issue.1 , pp. 26-41
    • Spragg, D.D.1    Kass, D.A.2
  • 44
    • 0036199464 scopus 로고    scopus 로고
    • Relation between local myocardial growth and blood flow during chronic ventricular pacing
    • DOI 10.1016/S0008-6363(01)00513-2, PII S0008636301005132
    • van Oosterhout, M. F., Arts, T., Bassingthwaighte, J. B., Reneman, R. S. & Prinzen, F. W. Relation between local myocardial growth and blood flow during chronic ventricular pacing. Cardiovasc. Res. 53, 831-840 (2002). (Pubitemid 34261021)
    • (2002) Cardiovascular Research , vol.53 , Issue.4 , pp. 831-840
    • Van Oosterhout, M.F.M.1    Arts, T.2    Bassingthwaighte, J.B.3    Reneman, R.S.4    Prinzen, F.W.5
  • 45
    • 0034687592 scopus 로고    scopus 로고
    • Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block
    • Nelson, G. S. et al. Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation 102, 3053-3059 (2000).
    • (2000) Circulation , vol.102 , pp. 3053-3059
    • Nelson, G.S.1
  • 46
    • 0037192318 scopus 로고    scopus 로고
    • Tissue doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure
    • Yu, C. M. et al. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation 105, 438-445 (2002).
    • (2002) Circulation , vol.105 , pp. 438-445
    • Yu, C.M.1
  • 47
    • 2442479695 scopus 로고    scopus 로고
    • Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    • Bristow, M. R. et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N. Engl. J. Med. 350, 2140-2150 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2140-2150
    • Bristow, M.R.1
  • 49
    • 78649323502 scopus 로고    scopus 로고
    • Rethinking resynch: Exploring mechanisms of cardiac resynchroniztion beyond wall motion control
    • Chakir, K. & Kass, D. A. Rethinking resynch: exploring mechanisms of cardiac resynchroniztion beyond wall motion control. Drug Discov. Today Dis. Mech. 7, e103-e107 (2010).
    • (2010) Drug Discov. Today Dis. Mech. , vol.7
    • Chakir, K.1    Kass, D.A.2
  • 50
    • 80052929596 scopus 로고    scopus 로고
    • Gas-biased β2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart
    • Chakir, K. et al. Gas-biased β2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Sci. Transl. Med. 3, 100ra88 (2011).
    • (2011) Sci. Transl. Med. , vol.3
    • Chakir, K.1
  • 51
    • 63649086323 scopus 로고    scopus 로고
    • Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy
    • Aiba, T. et al. Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation 119, 1220-1230 (2009).
    • (2009) Circulation , vol.119 , pp. 1220-1230
    • Aiba, T.1
  • 52
    • 70350440594 scopus 로고    scopus 로고
    • Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level
    • Barth, A. S. et al. Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level. Circ. Cardiovasc. Genet. 2, 371-378 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 371-378
    • Barth, A.S.1
  • 53
    • 80052970615 scopus 로고    scopus 로고
    • Redox regulation of mitochondrial ATP synthase: Implications for cardiac resynchronization therapy
    • Wang, S. B. et al. Redox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy. Circ. Res. 109, 750-757 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 750-757
    • Wang, S.B.1
  • 54
    • 0032544226 scopus 로고    scopus 로고
    • Regression of cellular hypertrophy after left ventricular assist device support
    • Zafeiridis, A., Jeevanandam, V., Houser, S. R. & Margulies, K. B. Regression of cellular hypertrophy after left ventricular assist device support. Circulation 98, 656-662 (1998). (Pubitemid 28387492)
    • (1998) Circulation , vol.98 , Issue.7 , pp. 656-662
    • Zafeiridis, A.1    Jeevanandam, V.2    Houser, S.R.3    Margulies, K.B.4
  • 55
    • 0345310053 scopus 로고    scopus 로고
    • Neurohormonal changes after implantation of a left ventricular assist system
    • Delgado, R. 3rd, Radovancevic, B., Massin, E. K., Frazier, O. H. & Benedict, C. Neurohormonal changes after implantation of a left ventricular assist system. ASAIO J. 44, 299-302 (1998). (Pubitemid 28328744)
    • (1998) ASAIO Journal , vol.44 , Issue.4 , pp. 299-302
    • Delcado, R.1    Radovancevic, B.2    Massin, E.K.3    Frazier, O.H.4    Benedict, C.5
  • 56
    • 0035822606 scopus 로고    scopus 로고
    • Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: A primary role of mechanical unloading underlying reverse remodeling
    • Barbone, A. et al. Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure: a primary role of mechanical unloading underlying reverse remodeling. Circulation 104, 670-675 (2001). (Pubitemid 32738521)
    • (2001) Circulation , vol.104 , Issue.6 , pp. 670-675
    • Barbone, A.1    Holmes, J.W.2    Heerdt, P.M.3    The, A.H.S.4    Naka, Y.5    Joshi, N.6    Daines, M.7    Marks, A.R.8    Oz, M.C.9    Burkhoff, D.10
  • 57
    • 3242810591 scopus 로고    scopus 로고
    • Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the endothelina receptor antagonist trial in heart failure EARTH: Randomised double-blind placebo-controlled trial
    • Anand, I. et al. Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial. Lancet 364, 347-354 (2004).
    • (2004) Lancet , vol.364 , pp. 347-354
    • Anand, I.1
  • 59
    • 2442652789 scopus 로고    scopus 로고
    • Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy
    • DOI 10.1161/01.CIR.0000129233.51320.92
    • Terracciano, C. M. et al. Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy. Circulation 109, 2263-2265 (2004). (Pubitemid 38656863)
    • (2004) Circulation , vol.109 , Issue.19 , pp. 2263-2265
    • Terracciano, C.M.N.1    Hardy, J.2    Birks, E.J.3    Khaghani, A.4    Banner, N.R.5    Yacoub, M.H.6
  • 60
    • 77955298123 scopus 로고    scopus 로고
    • Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart
    • Drakos, S. G. et al. Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart. J. Am. Coll. Cardiol. 56, 382-391 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 382-391
    • Drakos, S.G.1
  • 61
    • 0017315912 scopus 로고
    • Polyploidization of heart muscle nuclei as a prerequisite for heart growth and numerical hyperplasia in heart hypertrophy
    • Sandritter, W. & Adler, C. P. Polyploidization of heart muscle nuclei as a prerequisite for heart growth and numerical hyperplasia in heart hypertrophy. Recent Adv. Stud. Cardiac. Struct. Metab. 12, 115-127 (1976).
    • (1976) Recent Adv. Stud. Cardiac. Struct. Metab. , vol.12 , pp. 115-127
    • Sandritter, W.1    Adler, C.P.2
  • 62
    • 77649253431 scopus 로고    scopus 로고
    • Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart
    • Wohlschlaeger, J. et al. Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart. Circulation 121, 989-996 (2010).
    • (2010) Circulation , vol.121 , pp. 989-996
    • Wohlschlaeger, J.1
  • 65
    • 79751533489 scopus 로고    scopus 로고
    • Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: A prospective study
    • Birks, E. J. et al. Reversal of severe heart failure with a continuous-flow left ventricular assist device and pharmacological therapy: a prospective study. Circulation 123, 381-390 (2011).
    • (2011) Circulation , vol.123 , pp. 381-390
    • Birks, E.J.1
  • 66
    • 13444292824 scopus 로고    scopus 로고
    • Clinical applications of stem cells for the heart
    • DOI 10.1161/01.RES.0000155333.69009.63
    • Wollert, K. C. & Drexler, H. Clinical applications of stem cells for the heart. Circ. Res. 96, 151-163 (2005). (Pubitemid 40209362)
    • (2005) Circulation Research , vol.96 , Issue.2 , pp. 151-163
    • Wollert, K.C.1    Drexler, H.2
  • 68
    • 79954928346 scopus 로고    scopus 로고
    • Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: Functional recovery and reverse remodeling
    • Williams, A. R. et al. Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling. Circ. Res. 108, 792-796 (2011).
    • (2011) Circ. Res. , vol.108 , pp. 792-796
    • Williams, A.R.1
  • 69
    • 78751621958 scopus 로고    scopus 로고
    • Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction
    • Lee, S. T. et al. Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. J. Am. Coll. Cardiol. 57, 455-465 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.57 , pp. 455-465
    • Lee, S.T.1
  • 73
    • 0022623381 scopus 로고
    • Effect of vasodilator therapy on mortality in chronic congestive heart failure: Results of a Veterans Administration Cooperative Study
    • Cohn, J. N. et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study. N. Engl. J. Med. 314, 1547-1552 (1986). (Pubitemid 16114684)
    • (1986) New England Journal of Medicine , vol.314 , Issue.24 , pp. 1547-1552
    • Cohn, J.N.1    Archibald, D.G.2    Ziesche, S.3
  • 74
    • 0025770138 scopus 로고
    • A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure
    • Cohn, J. N. et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N. Engl. J. Med. 325, 303-310 (1991).
    • (1991) N. Engl. J. Med. , vol.325 , pp. 303-310
    • Cohn, J.N.1
  • 75
    • 19644400578 scopus 로고    scopus 로고
    • Combination of isosorbide dinitrate and hydralazine in blacks with heart failure
    • Taylor, A. L. et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N. Engl. J. Med. 351, 2049-2057 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2049-2057
    • Taylor, A.L.1
  • 77
    • 0033667404 scopus 로고    scopus 로고
    • Results of partial left ventriculectomy for dilated cardiomyopathy: Hemodynamic clinical and echocardiographic observations
    • Starling, R. C. et al. Results of partial left ventriculectomy for dilated cardiomyopathy: hemodynamic, clinical and echocardiographic observations. J. Am. Coll. Cardiol. 36, 2098-2103 (2000).
    • (2000) J. Am. Coll. Cardiol. , vol.36 , pp. 2098-2103
    • Starling, R.C.1
  • 79
    • 64549144270 scopus 로고    scopus 로고
    • Coronary bypass surgery with or without surgical ventricular reconstruction
    • Jones, R. H. et al. Coronary bypass surgery with or without surgical ventricular reconstruction. N. Engl. J. Med. 360, 1705-1717 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1705-1717
    • Jones, R.H.1
  • 80
    • 79955477301 scopus 로고    scopus 로고
    • Pharmacotherapy: Inhibiting LV remodeling-The need for a targeted approach
    • Cohn, J. N. Pharmacotherapy: inhibiting LV remodeling-the need for a targeted approach. Nat. Rev. Cardiol. 8, 248-249 (2011).
    • (2011) Nat. Rev. Cardiol. , vol.8 , pp. 248-249
    • Cohn, J.N.1
  • 81
    • 33847309058 scopus 로고    scopus 로고
    • Double-Blind, Randomized, Placebo-Controlled Study of High-Dose HMG CoA Reductase Inhibitor Therapy on Ventricular Remodeling, Pro-Inflammatory Cytokines and Neurohormonal Parameters in Patients With Chronic Systolic Heart Failure
    • DOI 10.1016/j.cardfail.2006.09.008, PII S1071916406012073
    • Krum, H. et al. Double-blind, randomized, placebo-controlled study of high-dose HMG CoA reductase inhibitor therapy on ventricular remodeling, pro-inflammatory cytokines and neurohormonal parameters in patients with chronic systolic heart failure. J. Card. Fail. 13, 1-7 (2007). (Pubitemid 46330836)
    • (2007) Journal of Cardiac Failure , vol.13 , Issue.1 , pp. 1-7
    • Krum, H.1    Ashton, E.2    Reid, C.3    Kalff, V.4    Rogers, J.5    Amarena, J.6    Singh, B.7    Tonkin, A.8
  • 83
    • 0028101383 scopus 로고
    • 2+-ATPase in failing and nonfailing human myocardium
    • 2+-ATPase in failing and nonfailing human myocardium. Circ. Res. 75, 434-442 (1994).
    • (1994) Circ. Res. , vol.75 , pp. 434-442
    • Hasenfuss, G.1
  • 86
    • 56349118816 scopus 로고    scopus 로고
    • Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals
    • Byrne, M. J. et al. Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals. Gene Ther. 15, 1550-1557 (2008).
    • (2008) Gene Ther. , vol.15 , pp. 1550-1557
    • Byrne, M.J.1
  • 87
    • 62649133817 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in cardiac disease CUPID trial a first in human phase 1/2 clinical trial
    • Jaski, B. E. et al. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first in human phase 1/2 clinical trial. J. Card. Fail. 15, 171-181 (2009).
    • (2009) J. Card. Fail. , vol.15 , pp. 171-181
    • Jaski, B.E.1
  • 88
    • 79961032369 scopus 로고    scopus 로고
    • 2+-ATPase in patients with advanced heart failure
    • 2+-ATPase in patients with advanced heart failure. Circulation 124, 304-313 (2011).
    • (2011) Circulation , vol.124 , pp. 304-313
    • Jessup, M.1
  • 89
    • 80053349683 scopus 로고    scopus 로고
    • SUMO1-dependent modulation of SERCA2a in heart failure
    • Kho, C. et al. SUMO1-dependent modulation of SERCA2a in heart failure. Nature 477, 601-605 (2011).
    • (2011) Nature , vol.477 , pp. 601-605
    • Kho, C.1
  • 90
    • 67349149420 scopus 로고    scopus 로고
    • Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
    • Tsai, E. J. & Kass, D. A. Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics. Pharmacol. Ther. 122, 216-238 (2009).
    • (2009) Pharmacol. Ther. , vol.122 , pp. 216-238
    • Tsai, E.J.1    Kass, D.A.2
  • 92
    • 58149104494 scopus 로고    scopus 로고
    • Sildenafil stops progressive chamber cellular and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload
    • Nagayama, T. et al. Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload. J. Am. Coll. Cardiol. 53, 207-215 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 207-215
    • Nagayama, T.1
  • 94
    • 33745812011 scopus 로고    scopus 로고
    • CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
    • DOI 10.1172/JCI27438
    • Backs, J., Song, K., Bezprozvannaya, S., Chang, S. & Olson, E. N. CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J. Clin. Invest. 116, 1853-1864 (2006). (Pubitemid 44033310)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1853-1864
    • Backs, J.1    Song, K.2    Bezprozvannaya, S.3    Chang, S.4    Olson, E.N.5
  • 95
    • 76349084460 scopus 로고    scopus 로고
    • 2+ handling but exacerbates cardiac dysfunction in CaMKIIdc transgenic mice
    • 2+ handling but exacerbates cardiac dysfunction in CaMKIIdc transgenic mice. Circ. Res. 106, 354-362 (2010).
    • (2010) Circ. Res. , vol.106 , pp. 354-362
    • Zhang, T.1
  • 96
    • 79551580284 scopus 로고    scopus 로고
    • PDE5 inhibition with sildenafil improves left ventricular diastolic function cardiac geometry and clinical status in patients with stable systolic heart failure: Results of a 1 year prospective randomized placebo-controlled study
    • Guazzi, M., Vicenzi, M., Arena, R. & Guazzi, M. D. PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1 year, prospective, randomized, placebo-controlled study. Circ. Heart Fail. 4, 8-17 (2011).
    • (2011) Circ. Heart Fail. , vol.4 , pp. 8-17
    • Guazzi, M.1    Vicenzi, M.2    Arena, R.3    Guazzi, M.D.4
  • 98
    • 0019982539 scopus 로고
    • Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts
    • Bristow, M. R. et al. Decreased catecholamine sensitivity and β adrenergic receptor density in failing human hearts. N. Engl. J. Med. 307, 205-211 (1982). (Pubitemid 12079105)
    • (1982) New England Journal of Medicine , vol.307 , Issue.4 , pp. 205-211
    • Bristow, M.R.1    Ginsburg, R.2    Minobe, W.3
  • 99
    • 36249021393 scopus 로고    scopus 로고
    • Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation
    • DOI 10.1016/j.molmed.2007.10.005, PII S147149140700189X
    • Lymperopoulos, A., Rengo, G. & Koch, W. J. Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation. Trends Mol. Med. 13, 503-511 (2007). (Pubitemid 350123195)
    • (2007) Trends in Molecular Medicine , vol.13 , Issue.12 , pp. 503-511
    • Lymperopoulos, A.1    Rengo, G.2    Koch, W.J.3
  • 100
    • 0030798818 scopus 로고    scopus 로고
    • Mechanism of β-adrenergic receptor desensitization in cardiac hypertrophy is increased β-adrenergic receptor kinase
    • DOI 10.1074/jbc.272.27.17223
    • Choi, D. J., Koch, W. J., Hunter, J. J. & Rockman, H. A. Mechanism of β adrenergic receptor desensitization in cardiac hypertrophy is increased β adrenergic receptor kinase. J. Biol. Chem. 272, 17223-17229 (1997). (Pubitemid 27289837)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.27 , pp. 17223-17229
    • Choi, D.-J.1    Koch, W.J.2    Hunter, J.J.3    Rockman, H.A.4
  • 103
    • 0029061324 scopus 로고
    • Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βaRK inhibitor
    • Koch, W. J. et al. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science 268, 1350-1353 (1995).
    • (1995) Science , vol.268 , pp. 1350-1353
    • Koch, W.J.1
  • 104
    • 50949099098 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure
    • Raake, P. W. et al. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ. Res. 103, 413-422 (2008).
    • (2008) Circ. Res. , vol.103 , pp. 413-422
    • Raake, P.W.1
  • 105
    • 59049097977 scopus 로고    scopus 로고
    • Myocardial adeno-associated virus serotype 6 βaRKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure
    • Rengo, G. et al. Myocardial adeno-associated virus serotype 6 βARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation 119, 89-98 (2009).
    • (2009) Circulation , vol.119 , pp. 89-98
    • Rengo, G.1
  • 110
    • 79953693561 scopus 로고    scopus 로고
    • S100A1 gene therapy for heart failure: A novel strategy on the verge of clinical trials
    • Rohde, D. et al. S100A1 gene therapy for heart failure: a novel strategy on the verge of clinical trials. J. Mol. Cell. Cardiol. 50, 777-784 (2011).
    • (2011) J. Mol. Cell. Cardiol. , vol.50 , pp. 777-784
    • Rohde, D.1
  • 111
    • 34848820302 scopus 로고    scopus 로고
    • β Arrestin mediated β1 adrenergic receptor transactivation of the EGFR confers cardioprotection
    • Noma, T. et al. β Arrestin mediated β1 adrenergic receptor transactivation of the EGFR confers cardioprotection. J. Clin. Invest. 117, 2445-2458 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 2445-2458
    • Noma, T.1
  • 114
    • 79960696509 scopus 로고    scopus 로고
    • Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model
    • 92ra64
    • Pleger, S. T. Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model. Sci. Transl. Med. 3, 92ra64 (2011).
    • (2011) Sci. Transl. Med. , vol.3
    • Pleger, S.T.1
  • 115
    • 77951835066 scopus 로고    scopus 로고
    • Thymosin β4: Structure function and biological properties supporting current and future clinical applications
    • Crockford, D., Turjman, N., Allan, C. & Angel, J. Thymosin β4: structure, function, and biological properties supporting current and future clinical applications. Ann. N. Y. Acad. Sci. 1194, 179-189 (2010).
    • (2010) Ann. N. Y. Acad. Sci. , vol.1194 , pp. 179-189
    • Crockford, D.1    Turjman, N.2    Allan, C.3    Angel, J.4
  • 116
    • 61749089404 scopus 로고    scopus 로고
    • Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
    • Takimoto, E. et al. Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J. Clin. Invest. 119, 408-420 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 408-420
    • Takimoto, E.1
  • 118
    • 77949274491 scopus 로고    scopus 로고
    • Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition
    • Koitabashi, N. et al. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. J. Mol. Cell. Cardiol. 48, 713-724 (2010).
    • (2010) J. Mol. Cell. Cardiol. , vol.48 , pp. 713-724
    • Koitabashi, N.1
  • 119
    • 9644281738 scopus 로고    scopus 로고
    • Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
    • DOI 10.1038/nature03000
    • Bock-Marquette, I., Saxena, A., White, M. D., Dimaio, J. M. & Srivastava, D. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432, 466-472 (2004). (Pubitemid 39576522)
    • (2004) Nature , vol.432 , Issue.7016 , pp. 466-472
    • Bock-Marquette, I.1    Saxena, A.2    White, M.D.3    DiMaio, J.M.4    Srivastava, D.5
  • 121
    • 79959819263 scopus 로고    scopus 로고
    • De novo cardiomyocytes from within the activated adult heart after injury
    • Smart, N. et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474, 640-644 (2011).
    • (2011) Nature , vol.474 , pp. 640-644
    • Smart, N.1
  • 123
    • 79960044552 scopus 로고    scopus 로고
    • CaMKII in myocardial hypertrophy and heart failure
    • Anderson, M. E., Brown, J. H. & Bers, D. M. CaMKII in myocardial hypertrophy and heart failure. J. Mol. Cell. Cardiol. 51, 468-473 (2011).
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 468-473
    • Anderson, M.E.1    Brown, J.H.2    Bers, D.M.3
  • 128
    • 80052801123 scopus 로고    scopus 로고
    • Protein kinase Ca as a heart failure therapeutic target
    • Liu, Q. & Molkentin, J. D. Protein kinase Ca as a heart failure therapeutic target. J. Mol. Cell. Cardiol. 51, 474-478 (2010).
    • (2010) J. Mol. Cell. Cardiol. , vol.51 , pp. 474-478
    • Liu, Q.1    Molkentin, J.D.2
  • 129
    • 77951520888 scopus 로고    scopus 로고
    • Gaq-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: The role of protein kinase C
    • Malhotra, R. et al. Gaq-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C. J. Biol. Chem. 285, 13748-13760 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 13748-13760
    • Malhotra, R.1
  • 131
    • 68049086486 scopus 로고    scopus 로고
    • Protein kinase Ca but not PKCβ or PKC regulates contractility and heart failure susceptibility: Implications for ruboxistaurin as a novel therapeutic approach
    • Liu, Q. et al. Protein kinase Ca, but not PKCβ or PKC?, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circ. Res. 105, 194-200 (2009).
    • (2009) Circ. Res. , vol.105 , pp. 194-200
    • Liu, Q.1
  • 133
    • 33947236725 scopus 로고    scopus 로고
    • Effect of ruboxistaurin in patients with diabetic macular edema: Thirty-month results of the randomized PKC-DMES clinical trial
    • PKC DMES Study Group
    • PKC DMES Study Group. Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial. Arch. Ophthalmol. 125, 318-324 (2007).
    • (2007) Arch. Ophthalmol. , vol.125 , pp. 318-324
  • 134
    • 33751520614 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy
    • PKC DRS2 Group et al.
    • PKC DRS2 Group et al. Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology 113, 2221-2230 (2006).
    • (2006) Ophthalmology , vol.113 , pp. 2221-2230
  • 135
    • 80051793072 scopus 로고    scopus 로고
    • Reversibility of adverse calcineurin-dependent cardiac remodeling
    • Berry, J. M. et al. Reversibility of adverse, calcineurin-dependent cardiac remodeling. Circ. Res. 109, 407-417 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 407-417
    • Berry, J.M.1
  • 136
    • 77958087459 scopus 로고    scopus 로고
    • TRP-ing up heart and vessels: Canonical transient receptor potential channels and cardiovascular disease
    • Rowell, J., Koitabashi, N. & Kass, D. A. TRP-ing up heart and vessels: canonical transient receptor potential channels and cardiovascular disease. J. Cardiovasc. Transl. Res. 3, 516-524 (2010).
    • (2010) J. Cardiovasc. Transl. Res. , vol.3 , pp. 516-524
    • Rowell, J.1    Koitabashi, N.2    Kass, D.A.3
  • 137
    • 0141653901 scopus 로고    scopus 로고
    • Ventricular remodeling after infarction and the extracellular collagen matrix: When is enough enough?
    • DOI 10.1161/01.CIR.0000085658.98621.49
    • Jugdutt, B. I. Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? Circulation 108, 1395-1403 (2003). (Pubitemid 37174420)
    • (2003) Circulation , vol.108 , Issue.11 , pp. 1395-1403
    • Jugdutt, B.I.1
  • 140
    • 78751507979 scopus 로고    scopus 로고
    • Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart
    • Creemers, E. E. & Pinto, Y. M. Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc. Res. 89, 265-272 (2011).
    • (2011) Cardiovasc. Res. , vol.89 , pp. 265-272
    • Creemers, E.E.1    Pinto, Y.M.2
  • 141
    • 79957888881 scopus 로고    scopus 로고
    • Pivotal role of cardiomyocyte TGF β signaling in the murine pathological response to sustained pressure overload
    • Koitabashi, N. et al. Pivotal role of cardiomyocyte TGF β signaling in the murine pathological response to sustained pressure overload. J. Clin. Invest. 121, 2301-2312 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2301-2312
    • Koitabashi, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.