R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals

Journal of Neurochemistry

Volumn 118, Issue 4, 2011, Pages 596-610

  Kelsall, Ian R ^a   Voss, Martin ^a   Munro, Shonagh ^a,c   Cuthbertson, Daniel J R ^b   Cohen, Patricia T W ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

adenosine; brain glycogen; diabetes; glycogen targeting subunit; protein phosphatase 1; signal transduction

Indexed keywords

ADENOSINE; ALANINE; COMPLEMENTARY DNA; GLUCOSE; GLYCOGEN; GLYCOGEN BINDING PROTEIN 3; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; NORADRENALIN; PHENYLALANINE; PHOSPHOPROTEIN PHOSPHATASE 1; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTOMA CELL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME REGULATION; EXTRACELLULAR SIGNALING; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOBLOTTING; MALE; MEMBRANE BINDING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADENOSINE; ADRENERGIC ALPHA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; ASTROCYTOMA; BRAIN; BRAIN NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; DNA; EXTRACELLULAR SPACE; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NOREPINEPHRINE; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; RNA; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

RODENTIA;

EID: 79960564311     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07345.x     Document Type: Article

References (57)

1. Allaman I., Pellerin L., and, Magistretti P. J., (2000) Protein targeting to glycogen mRNA expression is stimulated by noradrenaline in mouse cortical astrocytes. Glia, 30, 382-391. (Pubitemid 30334339)
2. Allaman I., Lengacher S., Magistretti P. J., and, Pellerin L., (2003) A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression. Am. J. Physiol. Cell Physiol., 284, C696-C704. (Pubitemid 36237522)
3. Allaman I., Pellerin L., and, Magistretti P. J., (2004) Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes. J. Neurochem., 88, 900-908. (Pubitemid 38199311)
4. Armstrong C. G., Browne G. J., Cohen P., and, Cohen P. T. W., (1997) PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1. FEBS Lett., 418, 210-214. (Pubitemid 27514448)
5. Armstrong C. G., Doherty M. J., and, Cohen P. T. W., (1998) Identification of the separate domains in the hepatic glycogen-targeting subunit of protein phosphatase 1 that interact with phosphorylase a, glycogen and protein phosphatase 1. Biochem. J., 336, 699-704. (Pubitemid 29008030)
6. M) is essential for activation of glycogen synthase by exercise. J. Biol. Chem., 276, 39959-39967.
7. Boison D., Chen J. F., and, Fredholm B. B., (2010) Adenosine signaling and function in glial cells. Cell Death Differ., 17, 1071-1082.
8. Bollen M., Keppens S., and, Stalmans W., (1998) Specific features of glycogen metabolism in the liver. Biochem. J., 336, 19-31. (Pubitemid 28532556)
9. Brown A. M., (2004) Brain glycogen re-awakened. J. Neurochem., 89, 537-552. (Pubitemid 38534140)
10. Brown A. M., and, Ransom B. R., (2007) Astrocyte glycogen and brain energy metabolism. Glia, 55, 1263-1271. (Pubitemid 47235367)
11. Browne G. J., Delibegovic M., Keppens S., Stalmans W., and, Cohen P. T. W., (2001) The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Biochem. J., 360, 449-459. (Pubitemid 33151340)
12. Cantarel B. L., Coutinho P. M., Rancurel C., Bernard T., Lombard V., and, Henrissat B., (2009) The Carbohydrate-Active EnZymes database (CAZy): an expert resource for glycogenomics. Nucleic Acids Res., 37, D233-238.
13. Cataldo A. M., and, Broadwell R. D., (1986) Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes. J. Neurocytol., 15, 511-524. (Pubitemid 16045887)
14. Ceulemans H., Stalmans W., and, Bollen M., (2002) Regulator-driven functional diversification of protein phosphatase 1 in eukaryotic evolution. Bioessays, 24, 371-381. (Pubitemid 34305692)
15. Chen Y. H., Hansen L., Chen M. X., Bjrbk C., Vestergaard H., Hansen T., Cohen P. T. W., and, Pedersen O., (1994) Sequence of the human glycogen associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with non-insulin-dependent diabetes mellitus. Diabetes, 43, 1234-1241. (Pubitemid 24361190)
16. Choi I. Y., Seaquist E. R., and, Gruetter R., (2003) Effect of hypoglycemia on brain glycogen metabolism in vivo. J. Neurosci. Res., 72, 25-32. (Pubitemid 36373808)
17. Cohen P., (1989) The structure and regulation of protein phosphatases. Annu. Rev. Biochem., 58, 453-508. (Pubitemid 19172978)
18. Crerar M. M., Karlsson O., Fletterick R. J., and, Hwang P. K., (1995) Chimeric muscle and brain glycogen phosphorylases define protein domains governing isozyme-specific responses to allosteric activation. J. Biol. Chem., 270, 13748-13756.
19. Delibegovic M., Armstrong C. A., Dobbie L., Watt P. W., Smith A. J. H., and, Cohen P. T. W., (2003) Disruption of the striated muscle glycogen targeting subunit, PPP1R3A, of protein phosphatase 1 leads to increased weight gain, fat deposition and development of insulin resistance. Diabetes, 52, 596-604. (Pubitemid 36323564)
20. Dixon A. K., Gubitz A. K., Sirinathsinghji D. J., Richardson P. J., and, Freeman T. C., (1996) Tissue distribution of adenosine receptor mRNAs in the rat. Br. J. Pharmacol., 118, 1461-1468. (Pubitemid 26248800)
21. L) subunit of protein phosphatase-1. FEBS Lett., 375, 284-298.
22. Doherty M. J., Young P. R., and, Cohen P. T. W., (1996) Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver and muscle specific glycogen binding subunits of protein phosphatase 1. FEBS Lett., 399, 339-343. (Pubitemid 26426878)
23. L) of protein phosphatase 1 underlies deficient glycogen synthesis in insulin-dependent diabetic rats and in adrenalectomized starved rats. Biochem. J., 333, 253-257.
24. Dunwiddie T. V., and, Masino S. A., (2001) The role and regulation of adenosine in the central nervous system. Annu. Rev. Neurosci., 24, 31-55. (Pubitemid 32695222)
25. Egloff M.-P., Johnson F., Moorhead G., Cohen P. T. W., Cohen P., and, Barford D., (1997) Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J., 16, 1876-1887. (Pubitemid 27170949)
26. Feoktistov I., and, Biaggioni I., (1997) Adenosine A2B receptors. Pharmacol. Rev., 49, 381-402.
27. Fong N. M., Jensen T. C., Shah A. S., Parekh N. N., Saltiel A. R., and, Brady M. J., (2000) Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism. J. Biol. Chem., 275, 35034-35039.
28. Gl) expressed in hepatocytes. J. Biol. Chem., 275, 26396-26403.
29. Gibbs M. E., Anderson D. G., and, Hertz L., (2006) Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens. Glia, 54, 214-222. (Pubitemid 44230858)
30. Gruetter R., (2003) Glycogen: the forgotten cerebral energy store. J. Neurosci. Res., 74, 179-183. (Pubitemid 37193703)
31. Halse R., Rochford J. J., McCormack J. G., Vandenheede J. R., Hemmings B. A., and, Yeaman S. J., (1999) Control of glycogen synthesis in cultured human muscle cells. J. Biol. Chem., 274, 776-780.
32. Hubbard M. J., and, Cohen P., (1989a) Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzyme. Eur. J. Biochem., 186, 701-709. (Pubitemid 20030125)
33. Hubbard M. J., and, Cohen P., (1989b) Regulation of protein phosphatase-1G from rabbit skeletal muscle. 2. Catalytic subunit translocation is a mechanism for reversible inhibition of activity toward glycogen-bound substrates. Eur. J. Biochem., 186, 711-716. (Pubitemid 20030126)
34. Kelsall I. R., Rosenzweig D., and, Cohen P. T., (2009) Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo. Cell. Signal., 21, 1123-1134.
35. GL, of the muscle-specific glycogen-associated type 1 protein phosphatase, PP1G. Arch. Biochem. Biophys., 388, 135-145. (Pubitemid 32911572)
36. Liu J., and, Brautigan D. L., (2000) Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. J. Biol. Chem., 275, 26074-26081.
37. Magistretti P. J., (2006) Neuron-glia metabolic coupling and plasticity. J. Exp. Biol., 209, 2304-2311. (Pubitemid 44065524)
38. McCrimmon R., (2008) The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes. Diabet. Med., 25, 513-522. (Pubitemid 351590875)
39. Moorhead G., MacKintosh C., Morrice N., and, Cohen P., (1995) Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. FEBS Lett., 362, 101-105.
40. Morgenthaler F. D., Koski D. M., Kraftsik R., Henry P. G., and, Gruetter R., (2006) Biochemical quantification of total brain glycogen concentration in rats under different glycemic states. Neurochem. Int., 48, 616-622.
41. Morgenthaler F. D., van Heeswijk R. B., Xin L., Laus S., Frenkel H., Lei H., and, Gruetter R., (2008) Non-invasive quantification of brain glycogen absolute concentration. J. Neurochem., 107, 1414-1423.
42. Munro S., Ceulemans H., Bollen M., Diplexcito J., and, Cohen P. T. W., (2005) A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. FEBS J., 272, 1478-1489. (Pubitemid 40444936)
43. Paterson J., Kelsall I. R., and, Cohen P. T. W., (2008) Disruption of the striated muscle glycogen targeting subunit of protein phosphatase 1: influence of the genetic background. J. Mol. Endocrinol., 40, 47-59. (Pubitemid 351279509)
44. Pellerin L., Bouzier-Sore A. K., Aubert A., Serres S., Merle M., Costalat R., and, Magistretti P. J., (2007) Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia, 55, 1251-1262. (Pubitemid 47235366)
45. Piton A., Gauthier J., Hamdan F. F., et al. (2010) Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Mol. Psychiatry, Published Online doi:.
46. Printen J. A., Brady M. J., and, Saltiel A. R., (1997) PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science, 275, 1475-1478. (Pubitemid 27111295)
47. Ring D. B., Johnson K. W., Henriksen E. J., et al. (2003) Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilisation in vitro and in vivo. Diabetes, 52, 588-595. (Pubitemid 36323563)
48. Roach P. J., (2002) Glycogen and its metabolism. Curr. Mol. Med., 2, 101-120. (Pubitemid 34649835)
49. Ross M. T., Grafham D. V., Coffey A. J., et al. (2005) The DNA sequence of the human X-chromosome. Nature, 434, 325-337.
50. Seaquist E. R., and, Gruetter R., (2002) Brain glycogen: an insulin-sensitive carbohydrate store. Diabetes Nutr. Metab., 15, 285-289; discussion 289-290.
51. Shevchenko A., Tomas H., Havlis J., Olsen J. V., and, Mann M., (2006) In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat. Protoc., 1, 2856-2860.
52. GL. Mol. Cell. Biol., 21, 2683-2694. (Pubitemid 32244913)
53. Suzuki A., Stern S. A., Bozdagi O., Huntley G. W., Walker R. H., Magistretti P. J., and, Alberini C. M., (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell, 144, 810-823.
54. Gl) Subunit of the glycogen associated protein phosphatase. J. Biol. Chem., 266, 15782-15789. (Pubitemid 21907726)
55. Toole B. J., and, Cohen P. T. W., (2007) The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo. Cell. Signal., 19, 1044-1055. (Pubitemid 46437437)
56. Williamson B. L., Marchese J., and, Morrice N. A., (2006) Automated identification and quantification of protein phosphorylation sites by LC/MS on a hybrid triple quadrupole linear ion trap mass spectrometer. Mol. Cell Proteomics, 5, 337-346. (Pubitemid 43329311)
57. Wu J., Liu J., Thompson I., Oliver C. J., Shenolikar S., and, Brautigan D. L., (1998) A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. FEBS Lett., 439, 185-191. (Pubitemid 28537889)