-
1
-
-
78650121847
-
Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies
-
Bernardo, B. C., Weeks, K. L., Pretorius, L. & McMullen, J. R. Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. Pharmacol. Ther. 128, 191-227 (2010).
-
(2010)
Pharmacol. Ther
, vol.128
, pp. 191-227
-
-
Bernardo, B.C.1
Weeks, K.L.2
Pretorius, L.3
McMullen, J.R.4
-
2
-
-
33748323383
-
Regulation of cardiac hypertrophy by intracellular signalling pathways
-
Heineke, J. & Molkentin, J. D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature Rev. Mol. Cell Biol. 7, 589-600 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol
, vol.7
, pp. 589-600
-
-
Heineke, J.1
Molkentin, J.D.2
-
3
-
-
84871516341
-
Signaling effectors underlying pathologic growth and remodeling of the heart
-
(in the press
-
Van Berlo, J. H., Maillet, M. & Molkentin, J. D. Signaling effectors underlying pathologic growth and remodeling of the heart. J. Clin. Invest. (in the press).
-
J. Clin. Invest.
-
-
Van Berlo, J.H.1
Maillet, M.2
Molkentin, J.D.3
-
4
-
-
64249107059
-
Evidence for cardiomyocyte renewal in humans
-
Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98-102 (2009).
-
(2009)
Science
, vol.324
, pp. 98-102
-
-
Bergmann, O.1
-
5
-
-
84867241732
-
Cardiomyogenesis in the aging and failing human heart
-
Kajstura, J. et al. Cardiomyogenesis in the aging and failing human heart. Circulation 126, 1869-1881 (2012).
-
(2012)
Circulation
, vol.126
, pp. 1869-1881
-
-
Kajstura, J.1
-
6
-
-
34247877577
-
The fuzzy logic of physiological cardiac hypertrophy
-
Dorn, G. W. The fuzzy logic of physiological cardiac hypertrophy. Hypertension 49, 962-970 (2007).
-
(2007)
Hypertension
, vol.49
, pp. 962-970
-
-
Dorn, G.W.1
-
7
-
-
54249167065
-
Early origins of cardiac hypertrophy: Does cardiomyocyte attrition programme for pathological 'catch-up' growth of the heart?
-
Porrello, E. R., Widdop, R. E. & Delbridge, L. M. Early origins of cardiac hypertrophy: does cardiomyocyte attrition programme for pathological 'catch-up' growth of the heart? Clin. Exp. Pharmacol. Physiol. 35, 1358-1364 (2008).
-
(2008)
Clin. Exp. Pharmacol. Physiol
, vol.35
, pp. 1358-1364
-
-
Porrello, E.R.1
Widdop, R.E.2
Delbridge, L.M.3
-
8
-
-
0015791192
-
Postnatal changes in rat ventricular function
-
Hopkins, S. F. Jr, McCutcheon, E. P. & Wekstein, D. R. Postnatal changes in rat ventricular function. Circ. Res. 32, 685-691 (1973).
-
(1973)
Circ. Res
, vol.32
, pp. 685-691
-
-
Hopkins Jr., S.F.1
McCutcheon, E.P.2
Wekstein, D.R.3
-
9
-
-
0021340250
-
Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy
-
Clubb, F. J. Jr & Bishop, S. P. Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy. Lab. Invest. 50, 571-577 (1984).
-
(1984)
Lab. Invest
, vol.50
, pp. 571-577
-
-
Clubb Jr., F.J.1
Bishop, S.P.2
-
10
-
-
33750016020
-
Heart hypertrophy during pregnancy: A better functioning heart? Trends Cardiovasc
-
Eghbali, M., Wang, Y., Toro, L. & Stefani, E. Heart hypertrophy during pregnancy: a better functioning heart? Trends Cardiovasc. Med. 16, 285-291 (2006).
-
(2006)
Med
, vol.16
, pp. 285-291
-
-
Eghbali, M.1
Wang, Y.2
Toro, L.3
Stefani, E.4
-
11
-
-
77049202424
-
Hypertrophy of the heart; Electrocardiographic distinction between physiologic and pathologic enlargement
-
Winsor, T. & Beckner, G. Hypertrophy of the heart; electrocardiographic distinction between physiologic and pathologic enlargement. Calif. Med. 82, 151-158 (1955).
-
(1955)
Calif. Med
, vol.82
, pp. 151-158
-
-
Winsor, T.1
Beckner, G.2
-
12
-
-
0002801008
-
Skilanglauf and skiwettlauf: ein medizinische sportstudie
-
Henschen, S. Skilanglauf and skiwettlauf: ein medizinische sportstudie. Mitt. Med. Klin. Uppsala 2, 15-18 (1899).
-
(1899)
Mitt. Med. Klin. Uppsala
, vol.2
, pp. 15-18
-
-
Henschen, S.1
-
13
-
-
0018882027
-
Echocardiographic evaluation of long-term effects of exercise on left ventricular hypertrophy and function in professional bicyclists
-
Nishimura, T., Yamada, Y. & Kawai, C. Echocardiographic evaluation of long-term effects of exercise on left ventricular hypertrophy and function in professional bicyclists. Circulation 61, 832-840 (1980).
-
(1980)
Circulation
, vol.61
, pp. 832-840
-
-
Nishimura, T.1
Yamada, Y.2
Kawai, C.3
-
14
-
-
0020659232
-
Myocardial mechanics of athletic hearts in comparison with diseased hearts
-
Sugishita, Y., Koseki, S., Matsuda, M., Yamaguchi, T. & Ito, I. Myocardial mechanics of athletic hearts in comparison with diseased hearts. Am. Heart J. 105, 273-280 (1983).
-
(1983)
Am. Heart J
, vol.105
, pp. 273-280
-
-
Sugishita, Y.1
Koseki, S.2
Matsuda, M.3
Yamaguchi, T.4
Ito, I.5
-
15
-
-
0022347675
-
Capacity for regression of the athletic heart
-
Dickhuth, H. H., Reindell, H., Lehmann, M. & Keul, J. [Capacity for regression of the athletic heart]. Z. Kardiol. 74 (Suppl. 7), 135-143 (1985).
-
(1985)
Z. Kardiol
, vol.74
, Issue.SUPPL. 7
, pp. 135-143
-
-
Dickhuth, H.H.1
Reindell, H.2
Lehmann, M.3
Keul, J.4
-
16
-
-
0036240947
-
Left ventricular hypertrophy and diastolic dysfunction in healthy pregnant women
-
Schannwell, C. M. et al. Left ventricular hypertrophy and diastolic dysfunction in healthy pregnant women. Cardiology 97, 73-78 (2002).
-
(2002)
Cardiology
, vol.97
, pp. 73-78
-
-
Schannwell, C.M.1
-
17
-
-
0034183039
-
Predicting heart growth during puberty: The Muscatine Study
-
Janz, K. F., Dawson, J. D. & Mahoney, L. T. Predicting heart growth during puberty: The Muscatine Study. Pediatrics 105, e63 (2000).
-
(2000)
Pediatrics
, vol.105
-
-
Janz, K.F.1
Dawson, J.D.2
Mahoney, L.T.3
-
18
-
-
0141959158
-
Postnatal anatomical and functional development of the heart: A species comparison
-
Hew, K. W. & Keller, K. A. Postnatal anatomical and functional development of the heart: a species comparison. Birth Defects Res. B. Dev. Reprod. Toxicol. 68, 309-320 (2003).
-
(2003)
Birth Defects Res. B. Dev. Reprod. Toxicol
, vol.68
, pp. 309-320
-
-
Hew, K.W.1
Keller, K.A.2
-
19
-
-
0034711754
-
The athlete's heart. A meta-analysis of cardiac structure and function
-
Pluim, B. M., Zwinderman, A. H., van der Laarse, A. & van der Wall, E. E. The athlete's heart. A meta-analysis of cardiac structure and function. Circulation 101, 336-344 (2000).
-
(2000)
Circulation
, vol.101
, pp. 336-344
-
-
Pluim, B.M.1
Zwinderman, A.H.2
Van Der Laarse, A.3
Van Der Wall, E.E.4
-
20
-
-
0018144643
-
Rapid changes in left ventricular dimensions and mass in response to physical conditioning and deconditioning
-
Ehsani, A. A., Hagberg, J. M. & Hickson, R. C. Rapid changes in left ventricular dimensions and mass in response to physical conditioning and deconditioning. Am. J. Cardiol. 42, 52-56 (1978).
-
(1978)
Am. J. Cardiol
, vol.42
, pp. 52-56
-
-
Ehsani, A.A.1
Hagberg, J.M.2
Hickson, R.C.3
-
21
-
-
0027402810
-
Reduction in left ventricular wall thickness after deconditioning in highly trained Olympic athletes
-
Maron, B. J., Pelliccia, A., Spataro, A. & Granata, M. Reduction in left ventricular wall thickness after deconditioning in highly trained Olympic athletes. Br. Heart J. 69, 125-128 (1993).
-
(1993)
Br. Heart J
, vol.69
, pp. 125-128
-
-
Maron, B.J.1
Pelliccia, A.2
Spataro, A.3
Granata, M.4
-
22
-
-
84871518146
-
Genetics of sudden cardiac death in children and young athletes
-
Sarquella-Brugada, G. et al. Genetics of sudden cardiac death in children and young athletes. Cardiol. Young 24, 1-15 (2012).
-
(2012)
Cardiol. Young
, vol.24
, pp. 1-15
-
-
Sarquella-Brugada, G.1
-
23
-
-
84861058134
-
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy
-
Patten, I. S. et al. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 485, 333-338 (2012).
-
(2012)
Nature
, vol.485
, pp. 333-338
-
-
Patten, I.S.1
-
24
-
-
0017048582
-
Studies on the regulation of myocardial blood flow in man. I. : Training effects on blood flow and metabolism of the healthy heart at rest and during standardized heavy exercise
-
Heiss, H. W. et al. Studies on the regulation of myocardial blood flow in man. I. : Training effects on blood flow and metabolism of the healthy heart at rest and during standardized heavy exercise. Bas. Res. Cardiol. 71, 658-675 (1976).
-
(1976)
Bas. Res. Cardiol
, vol.71
, pp. 658-675
-
-
Heiss, H.W.1
-
25
-
-
0025323254
-
Coronary arteries in physiological hypertrophy: Echocardiographic evidence of increased proximal size in elite athletes
-
Pelliccia, A. et al. Coronary arteries in physiological hypertrophy: echocardiographic evidence of increased proximal size in elite athletes. Int. J. Sports Med. 11, 120-126 (1990).
-
(1990)
Int. J. Sports Med
, vol.11
, pp. 120-126
-
-
Pelliccia, A.1
-
27
-
-
77955980416
-
Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation
-
Lopaschuk, G. D. & Jaswal, J. S. Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. J. Cardiovasc. Pharmacol. 56, 130-140 (2010).
-
(2010)
J. Cardiovasc. Pharmacol
, vol.56
, pp. 130-140
-
-
Lopaschuk, G.D.1
Jaswal, J.S.2
-
28
-
-
0024267688
-
Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments
-
Gertz, E. W., Wisneski, J. A., Stanley, W. C. & Neese, R. A. Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments. J. Clin. Invest. 82, 2017-2025 (1988).
-
(1988)
J. Clin. Invest
, vol.82
, pp. 2017-2025
-
-
Gertz, E.W.1
Wisneski, J.A.2
Stanley, W.C.3
Neese, R.A.4
-
29
-
-
79955391768
-
Mitochondrial adaptations to physiological versus pathological cardiac hypertrophy
-
Abel, E. D. & Doenst, T. Mitochondrial adaptations to physiological versus pathological cardiac hypertrophy. Cardiovasc. Res. 90, 234-242 (2011).
-
(2011)
Cardiovasc. Res
, vol.90
, pp. 234-242
-
-
Abel, E.D.1
Doenst, T.2
-
30
-
-
0347320747
-
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy
-
Wilkins, B. J. et al. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ. Res. 94, 110-118 (2004).
-
(2004)
Circ. Res
, vol.94
, pp. 110-118
-
-
Wilkins, B.J.1
-
31
-
-
0030042756
-
Exercise-and hypertension-induced collagen changes are related to left ventricular function in rat hearts
-
Burgess, M. L. et al. Exercise-and hypertension-induced collagen changes are related to left ventricular function in rat hearts. Am. J. Physiol. 270, H151-H159 (1996).
-
(1996)
Am. J. Physiol
, vol.270
-
-
Burgess, M.L.1
-
32
-
-
0034537227
-
Effects of exercise training on cardiac function, gene expression, and apoptosis in rats
-
Jin, H. et al. Effects of exercise training on cardiac function, gene expression, and apoptosis in rats. Am. J. Physiol. Heart Circ. Physiol. 279, H2994-H3002 (2000).
-
(2000)
Am. J. Physiol. Heart Circ. Physiol
, vol.279
-
-
Jin, H.1
-
33
-
-
0035941414
-
Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes
-
Neri Serneri, G. G. et al. Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circ. Res. 89, 977-982 (2001).
-
(2001)
Circ. Res
, vol.89
, pp. 977-982
-
-
Neri Serneri, G.G.1
-
34
-
-
18844473540
-
Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia
-
Bellomo, D. et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ. Res. 86, e29-e35 (2000).
-
(2000)
Circ. Res
, vol.86
-
-
Bellomo, D.1
-
35
-
-
55449118233
-
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
-
Karpanen, T. et al. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ. Res. 103, 1018-1026 (2008).
-
(2008)
Circ. Res
, vol.103
, pp. 1018-1026
-
-
Karpanen, T.1
-
36
-
-
78149281188
-
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
-
Bry, M. et al. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation 122, 1725-1733 (2010).
-
(2010)
Circulation
, vol.122
, pp. 1725-1733
-
-
Bry, M.1
-
37
-
-
0017834609
-
Thyroxine-binding globulin, triiodothyronine, thyroxine and thyrotropin in newborn infants and children
-
Stubbe, P., Gatz, J., Heidemann, P., Muhlen, A. & Hesch, R. Thyroxine-binding globulin, triiodothyronine, thyroxine and thyrotropin in newborn infants and children. Horm. Metab. Res. 10, 58-61 (1978).
-
(1978)
Horm. Metab. Res
, vol.10
, pp. 58-61
-
-
Stubbe, P.1
Gatz, J.2
Heidemann, P.3
Muhlen, A.4
Hesch, R.5
-
38
-
-
0033983077
-
Hypothyroidism prolongs mitotic activity in the post-natal mouse brain
-
Hadj-Sahraoui, N., Seugnet, I., Ghorbel, M. T. & Demeneix, B. Hypothyroidism prolongs mitotic activity in the post-natal mouse brain. Neurosci. Lett. 280, 79-82 (2000).
-
(2000)
Neurosci. Lett
, vol.280
, pp. 79-82
-
-
Hadj-Sahraoui, N.1
Seugnet, I.2
Ghorbel, M.T.3
Demeneix, B.4
-
39
-
-
0027161712
-
Regulation of myosin heavy chain genes in the heart
-
Morkin, E. Regulation of myosin heavy chain genes in the heart. Circulation 87, 1451-1460 (1993).
-
(1993)
Circulation
, vol.87
, pp. 1451-1460
-
-
Morkin, E.1
-
40
-
-
80052796846
-
Translational potential of thyroid hormone and its analogs
-
Arsanjani, R., McCarren, M., Bahl, J. J. & Goldman, S. Translational potential of thyroid hormone and its analogs. J. Mol. Cell. Cardiol. 51, 506-511 (2011).
-
(2011)
J. Mol. Cell. Cardiol
, vol.51
, pp. 506-511
-
-
Arsanjani, R.1
McCarren, M.2
Bahl, J.J.3
Goldman, S.4
-
41
-
-
33746337947
-
Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways
-
Kenessey, A. & Ojamaa, K. Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. J. Biol. Chem. 281, 20666-20672 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 20666-20672
-
-
Kenessey, A.1
Ojamaa, K.2
-
42
-
-
33644802342
-
Nuclear localization of protein kinase C-α induces thyroid hormone receptor-α1 expression in the cardiomyocyte
-
Kenessey, A., Sullivan, E. A. & Ojamaa, K. Nuclear localization of protein kinase C-α induces thyroid hormone receptor-α1 expression in the cardiomyocyte. Am. J. Physiol. Heart Circ. Physiol. 290, H381-H389 (2006).
-
(2006)
Am. J. Physiol. Heart Circ. Physiol
, vol.290
-
-
Kenessey, A.1
Sullivan, E.A.2
Ojamaa, K.3
-
43
-
-
77954487877
-
Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-α1 and involves targeted covalent histone modifications
-
Belakavadi, M., Saunders, J., Weisleder, N., Raghava, P. S. & Fondell, J. D. Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-α1 and involves targeted covalent histone modifications. Endocrinology 151, 2946-2956 (2010).
-
(2010)
Endocrinology
, vol.151
, pp. 2946-2956
-
-
Belakavadi, M.1
Saunders, J.2
Weisleder, N.3
Raghava, P.S.4
Fondell, J.D.5
-
44
-
-
0030900355
-
Actions of insulin on the mammalian heart: Metabolism, pathology and biochemical mechanisms
-
Brownsey, R. W., Boone, A. N. & Allard, M. F. Actions of insulin on the mammalian heart: metabolism, pathology and biochemical mechanisms. Cardiovasc. Res. 34, 3-24 (1997).
-
(1997)
Cardiovasc. Res
, vol.34
, pp. 3-24
-
-
Brownsey, R.W.1
Boone, A.N.2
Allard, M.F.3
-
45
-
-
33845711358
-
Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
-
Shiojima, I. & Walsh, K. Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev. 20, 3347-3365 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 3347-3365
-
-
Shiojima, I.1
Walsh, K.2
-
46
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki, E. et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372, 186-190 (1994).
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
-
47
-
-
0034699544
-
IRS-2 pathways integrate female reproduction and energy homeostasis
-
Burks, D. J. et al. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407, 377-382 (2000).
-
(2000)
Nature
, vol.407
, pp. 377-382
-
-
Burks, D.J.1
-
48
-
-
0036192939
-
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
-
Belke, D. D. et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J. Clin. Invest. 109, 629-639 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 629-639
-
-
Belke, D.D.1
-
49
-
-
0041357130
-
Minimally invasive aortic banding in mice: Effects of altered cardiomyocyte insulin signaling during pressure overload
-
Hu, P. et al. Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am. J. Physiol. Heart Circ. Physiol. 285, H1261-H1269 (2003).
-
(2003)
Am. J. Physiol. Heart Circ. Physiol
, vol.285
-
-
Hu, P.1
-
50
-
-
67349258584
-
Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction
-
Sena, S. et al. Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction. J. Mol. Cell. Cardiol. 46, 910-918 (2009).
-
(2009)
J. Mol. Cell. Cardiol
, vol.46
, pp. 910-918
-
-
Sena, S.1
-
51
-
-
63649106676
-
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
-
Boudina, S. et al. Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation 119, 1272-1283 (2009).
-
(2009)
Circulation
, vol.119
, pp. 1272-1283
-
-
Boudina, S.1
-
52
-
-
0031740792
-
Genetics of mouse growth
-
Efstratiadis, A. Genetics of mouse growth. Int. J. Dev. Biol. 42, 955-976 (1998).
-
(1998)
Int. J. Dev. Biol
, vol.42
, pp. 955-976
-
-
Efstratiadis, A.1
-
53
-
-
0017097114
-
Growth hormone in exercise: Comparison of physiological and pharmacological stimuli
-
Sutton, J. & Lazarus, L. A. Growth hormone in exercise: comparison of physiological and pharmacological stimuli. J. Appl. Physiol. 41, 523-527 (1976).
-
(1976)
J. Appl. Physiol
, vol.41
, pp. 523-527
-
-
Sutton, J.1
Lazarus, L.A.2
-
54
-
-
0027423419
-
Role of insulin-like growth factors in embryonic and postnatal growth
-
Baker, J., Liu, J. P., Robertson, E. J. & Efstratiadis, A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73-82 (1993).
-
(1993)
Cell
, vol.75
, pp. 73-82
-
-
Baker, J.1
Liu, J.P.2
Robertson, E.J.3
Efstratiadis, A.4
-
55
-
-
0027496895
-
Mice carrying null mutations of the genes encoding insulin-like growth factor i (Igf-1) and type 1 IGF receptor (Igf1r
-
Liu, J. P., Baker, J., Perkins, A. S., Robertson, E. J. & Efstratiadis, A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59-72 (1993).
-
(1993)
Cell
, vol.75
, pp. 59-72
-
-
Liu, J.P.1
Baker, J.2
Perkins, A.S.3
Robertson, E.J.4
Efstratiadis, A.5
-
56
-
-
9444269796
-
Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice
-
Reiss, K. et al. Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc. Natl Acad. Sci. USA 93, 8630-8635 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 8630-8635
-
-
Reiss, K.1
-
57
-
-
0033228631
-
Local insulin-like growth factor i expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice
-
Delaughter, M. C., Taffet, G. E., Fiorotto, M. L., Entman, M. L. & Schwartz, R. J. Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice. FASEB J. 13, 1923-1929 (1999).
-
(1999)
FASEB J
, vol.13
, pp. 1923-1929
-
-
Delaughter, M.C.1
Taffet, G.E.2
Fiorotto, M.L.3
Entman, M.L.4
Schwartz, R.J.5
-
58
-
-
10744223902
-
The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110α) pathway
-
McMullen, J. R. et al. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110α) pathway. J. Biol. Chem. 279, 4782-4793 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 4782-4793
-
-
McMullen, J.R.1
-
59
-
-
55049090844
-
Insulin-like growth factor i receptor signaling is required for exercise-induced cardiac hypertrophy
-
Kim, J. et al. Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol. Endocrinol. 22, 2531-2543 (2008).
-
(2008)
Mol. Endocrinol
, vol.22
, pp. 2531-2543
-
-
Kim, J.1
-
60
-
-
84863966855
-
IGF-IR signaling attenuates the age-related decline of diastolic cardiac function
-
Moellendorf, S. et al. IGF-IR signaling attenuates the age-related decline of diastolic cardiac function. Am. J. Physiol. Endocrinol. Metab. 303, e213-e222 (2012).
-
(2012)
Am. J. Physiol. Endocrinol. Metab
, vol.303
-
-
Moellendorf, S.1
-
61
-
-
77955473072
-
Canonical TRP channels and mechanotransduction: From physiology to disease states
-
Patel, A. et al. Canonical TRP channels and mechanotransduction: from physiology to disease states. Pflugers Arch. 460, 571-581 (2010).
-
(2010)
Pflugers Arch
, vol.460
, pp. 571-581
-
-
Patel, A.1
-
62
-
-
0033526991
-
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1
-
Musarς, A., McCullagh, K. J., Naya, F. J., Olson, E. N. & Rosenthal, N. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature 400, 581-585 (1999).
-
(1999)
Nature
, vol.400
, pp. 581-585
-
-
Musar, A.1
McCullagh, K.J.2
Naya, F.J.3
Olson, E.N.4
Rosenthal, N.5
-
63
-
-
13944263659
-
TRPC1 forms the stretch-activated cation channel in vertebrate cells
-
Maroto, R. et al. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nature Cell Biol. 7, 179-185 (2005).
-
(2005)
Nature Cell Biol
, vol.7
, pp. 179-185
-
-
Maroto, R.1
-
64
-
-
33750802650
-
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
-
Spassova, M. A., Hewavitharana, T., Xu, W., Soboloff, J. & Gill, D. L. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc. Natl Acad. Sci. USA 103, 16586-16591 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 16586-16591
-
-
Spassova, M.A.1
Hewavitharana, T.2
Xu, W.3
Soboloff, J.4
Gill, D.L.5
-
65
-
-
72449170101
-
TRPC1 channels are critical for hypertrophic signaling in the heart
-
Seth, M. et al. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ. Res. 105, 1023-1030 (2009).
-
(2009)
Circ. Res
, vol.105
, pp. 1023-1030
-
-
Seth, M.1
-
66
-
-
77951071535
-
TRPC channels are necessary mediators of pathologic cardiac hypertrophy
-
Wu, X., Eder, P., Chang, B. & Molkentin, J. D. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc. Natl Acad. Sci. USA 107, 7000-7005 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 7000-7005
-
-
Wu, X.1
Eder, P.2
Chang, B.3
Molkentin, J.D.4
-
67
-
-
0037040839
-
Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure
-
Shai, S. Y. et al. Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure. Circ. Res. 90, 458-464 (2002).
-
(2002)
Circ. Res
, vol.90
, pp. 458-464
-
-
Shai, S.Y.1
-
68
-
-
68849083046
-
β3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy
-
Johnston, R. K. et al. β3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy. FASEB J. 23, 2759-2771 (2009).
-
(2009)
FASEB J
, vol.23
, pp. 2759-2771
-
-
Johnston, R.K.1
-
69
-
-
56349153013
-
A broken heart: A stretch too far: An overview of mouse models with mutations in stretch-sensor components
-
Cox, L., Umans, L., Cornelis, F., Huylebroeck, D. & Zwijsen, A. A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components. Int. J. Cardiol. 131, 33-44 (2008).
-
(2008)
Int. J. Cardiol
, vol.131
, pp. 33-44
-
-
Cox, L.1
Umans, L.2
Cornelis, F.3
Huylebroeck, D.4
Zwijsen, A.5
-
70
-
-
39749137483
-
Sense and stretchability: The role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction
-
Linke, W. A. Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction. Cardiovasc. Res. 77, 637-648 (2008).
-
(2008)
Cardiovasc. Res
, vol.77
, pp. 637-648
-
-
Linke, W.A.1
-
71
-
-
84863116641
-
Truncations of titin causing dilated cardiomyopathy
-
Herman, D. S. et al. Truncations of titin causing dilated cardiomyopathy. N. Engl. J. Med. 366, 619-628 (2012).
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 619-628
-
-
Herman, D.S.1
-
72
-
-
0034213075
-
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
-
Shioi, T. et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19, 2537-2548 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 2537-2548
-
-
Shioi, T.1
-
73
-
-
0142027759
-
Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
-
McMullen, J. R. et al. Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc. Natl Acad. Sci. USA 100, 12355-12360 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 12355-12360
-
-
McMullen, J.R.1
-
74
-
-
27144536566
-
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy
-
Luo, J. et al. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol. Cell. Biol. 25, 9491-9502 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 9491-9502
-
-
Luo, J.1
-
75
-
-
68249087374
-
Loss of cardiac phosphoinositide 3-kinase p110α results in contractile dysfunction
-
Lu, Z. et al. Loss of cardiac phosphoinositide 3-kinase p110α results in contractile dysfunction. Circulation 120, 318-325 (2009).
-
(2009)
Circulation
, vol.120
, pp. 318-325
-
-
Lu, Z.1
-
76
-
-
18644372367
-
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
-
Crackower, M. A. et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110, 737-749 (2002).
-
(2002)
Cell
, vol.110
, pp. 737-749
-
-
Crackower, M.A.1
-
77
-
-
2942563750
-
3 binding to PDK1 PH domain defined by knockin mutation
-
McManus, E. J. et al. The in vivo role of PtdIns(3, 4, 5) P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J. 23, 2071-2082 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 2071-2082
-
-
McManus, E.J.1
-
78
-
-
0141737071
-
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
-
Mora, A. et al. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J. 22, 4666-4676 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 4666-4676
-
-
Mora, A.1
-
79
-
-
3242698804
-
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
-
Oudit, G. Y. et al. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J. Mol. Cell. Cardiol. 37, 449-471 (2004).
-
(2004)
J. Mol. Cell. Cardiol
, vol.37
, pp. 449-471
-
-
Oudit, G.Y.1
-
80
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ
-
Cho, H. et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292, 1728-1731 (2001).
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
-
81
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
Chen, W. S. et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15, 2203-2208 (2001).
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
-
82
-
-
0035914388
-
Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F. & Birnbaum, M. J. Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 276, 38349-38352 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
83
-
-
33646449520
-
Akt1 is required for physiological cardiac growth
-
DeBosch, B. et al. Akt1 is required for physiological cardiac growth. Circulation 113, 2097-2104 (2006).
-
(2006)
Circulation
, vol.113
, pp. 2097-2104
-
-
Debosch, B.1
-
84
-
-
0036200937
-
Akt/protein kinase B promotes organ growth in transgenic mice
-
Shioi, T. et al. Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22, 2799-2809 (2002).
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 2799-2809
-
-
Shioi, T.1
-
85
-
-
0037151104
-
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
-
Matsui, T. et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J. Biol. Chem. 277, 22896-22901 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 22896-22901
-
-
Matsui, T.1
-
86
-
-
0037125980
-
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
-
Condorelli, G. et al. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc. Natl Acad. Sci. USA 99, 12333-12338 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 12333-12338
-
-
Condorelli, G.1
-
87
-
-
23644439061
-
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
-
Shiojima, I. et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115, 2108-2118 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, pp. 2108-2118
-
-
Shiojima, I.1
-
88
-
-
1842830427
-
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes
-
Shiraishi, I. et al. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ. Res. 94, 884-891 (2004).
-
(2004)
Circ. Res
, vol.94
, pp. 884-891
-
-
Shiraishi, I.1
-
89
-
-
33644699984
-
Nuclear targeting of Akt enhances ventricular function and myocyte contractility
-
Rota, M. et al. Nuclear targeting of Akt enhances ventricular function and myocyte contractility. Circ. Res. 97, 1332-1341 (2005).
-
(2005)
Circ. Res
, vol.97
, pp. 1332-1341
-
-
Rota, M.1
-
90
-
-
0034597147
-
Glycogen synthase kinase-3β is a negative regulator of cardiomyocyte hypertrophy
-
Haq, S. et al. Glycogen synthase kinase-3β is a negative regulator of cardiomyocyte hypertrophy. J. Cell. Biol. 151, 117-130 (2000).
-
(2000)
J. Cell. Biol
, vol.151
, pp. 117-130
-
-
Haq, S.1
-
91
-
-
0037154168
-
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
-
Antos, C. L. et al. Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo. Proc. Natl Acad. Sci. USA 99, 907-912 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 907-912
-
-
Antos, C.L.1
-
92
-
-
2442714120
-
Glycogen synthase kinase-3β regulates growth, calcium homeostasis, and diastolic function in the heart
-
Michael, A. et al. Glycogen synthase kinase-3β regulates growth, calcium homeostasis, and diastolic function in the heart. J. Biol. Chem. 279, 21383-21393 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 21383-21393
-
-
Michael, A.1
-
93
-
-
20144368308
-
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling
-
Skurk, C. et al. The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J. Biol. Chem. 280, 20814-20823 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 20814-20823
-
-
Skurk, C.1
-
94
-
-
79952577412
-
Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin
-
Malhowski, A. J. et al. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum. Mol. Genet. 20, 1290-1305 (2011).
-
(2011)
Hum. Mol. Genet
, vol.20
, pp. 1290-1305
-
-
Malhowski, A.J.1
-
95
-
-
55649092252
-
Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes
-
Wang, Y. et al. Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 45, 812-820 (2008).
-
(2008)
J. Mol. Cell. Cardiol
, vol.45
, pp. 812-820
-
-
Wang, Y.1
-
96
-
-
46649112177
-
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
-
Shen, W. H. et al. Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function. J. Biol. Chem. 283, 13842-13849 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 13842-13849
-
-
Shen, W.H.1
-
97
-
-
77955290360
-
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice
-
Zhang, D. et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J. Clin. Invest. 120, 2805-2816 (2010).
-
(2010)
J. Clin. Invest
, vol.120
, pp. 2805-2816
-
-
Zhang, D.1
-
98
-
-
79953033875
-
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice
-
Shende, P. et al. Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation 123, 1073-1082 (2011).
-
(2011)
Circulation
, vol.123
, pp. 1073-1082
-
-
Shende, P.1
-
99
-
-
3042707485
-
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy
-
McMullen, J. R. et al. Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Mol. Cell. Biol. 24, 6231-6240 (2004).
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 6231-6240
-
-
McMullen, J.R.1
-
100
-
-
79952073585
-
The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation
-
Tsukada, J., Yoshida, Y., Kominato, Y. & Auron, P. E. The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation. Cytokine 54, 6-19 (2011).
-
(2011)
Cytokine
, vol.54
, pp. 6-19
-
-
Tsukada, J.1
Yoshida, Y.2
Kominato, Y.3
Auron, P.E.4
-
101
-
-
78650472007
-
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling
-
Bostrom, P. et al. C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell 143, 1072-1083 (2010).
-
(2010)
Cell
, vol.143
, pp. 1072-1083
-
-
Bostrom, P.1
-
102
-
-
0034383952
-
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
-
Bueno, O. F. et al. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 19, 6341-6350 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 6341-6350
-
-
Bueno, O.F.1
-
103
-
-
11144358069
-
MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo
-
Lips, D. J. et al. MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation 109, 1938-1941 (2004).
-
(2004)
Circulation
, vol.109
, pp. 1938-1941
-
-
Lips, D.J.1
-
104
-
-
35348921181
-
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo
-
Purcell, N. H. et al. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc. Natl Acad. Sci. USA 104, 14074-14079 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 14074-14079
-
-
Purcell, N.H.1
-
105
-
-
79251617662
-
Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth
-
Kehat, I. et al. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ. Res. 108, 176-183 (2011).
-
(2011)
Circ. Res
, vol.108
, pp. 176-183
-
-
Kehat, I.1
-
106
-
-
77649162900
-
Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy
-
Kehat, I. & Molkentin, J. D. Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy. Ann. NY Acad. Sci. 1188, 96-102 (2010).
-
(2010)
Ann. NY Acad. Sci
, vol.1188
, pp. 96-102
-
-
Kehat, I.1
Molkentin, J.D.2
-
107
-
-
84871899214
-
AMP-activated protein kinase in the control of cardiac metabolism and remodeling
-
Horman, S., Beauloye, C., Vanoverschelde, J. L. & Bertrand, L. AMP-activated protein kinase in the control of cardiac metabolism and remodeling. Curr. Heart Fail. Rep. 9, 164-173 (2012).
-
(2012)
Curr. Heart Fail. Rep
, vol.9
, pp. 164-173
-
-
Horman, S.1
Beauloye, C.2
Vanoverschelde, J.L.3
Bertrand, L.4
-
108
-
-
19944369735
-
Adiponectin-mediated modulation of hypertrophic signals in the heart
-
Shibata, R. et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nature Med. 10, 1384-1389 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 1384-1389
-
-
Shibata, R.1
-
109
-
-
53449089289
-
AMPKα2 counteracts the development of cardiac hypertrophy induced by isoproterenol
-
Zarrinpashneh, E. et al. AMPKα2 counteracts the development of cardiac hypertrophy induced by isoproterenol. Biochem. Biophys. Res. Commun. 376, 677-681 (2008).
-
(2008)
Biochem. Biophys. Res. Commun
, vol.376
, pp. 677-681
-
-
Zarrinpashneh, E.1
-
110
-
-
55949114398
-
AMP activated protein kinase-α2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice
-
Zhang, P. et al. AMP activated protein kinase-α2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension 52, 918-924 (2008).
-
(2008)
Hypertension
, vol.52
, pp. 918-924
-
-
Zhang, P.1
-
111
-
-
33646420605
-
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1
-
Sakamoto, K. et al. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1. Am. J. Physiol. Endocrinol. Metab. 290, e780-e788 (2006).
-
(2006)
Am. J. Physiol. Endocrinol. Metab
, vol.290
-
-
Sakamoto, K.1
-
112
-
-
72149093508
-
Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction
-
Ikeda, Y. et al. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J. Biol. Chem. 284, 35839-35849 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, pp. 35839-35849
-
-
Ikeda, Y.1
-
113
-
-
61949300140
-
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
-
Gundewar, S. et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ. Res. 104, 403-411 (2009).
-
(2009)
Circ. Res
, vol.104
, pp. 403-411
-
-
Gundewar, S.1
-
114
-
-
34347249232
-
Exercise reverses preamyloid oligomer and prolongs survival in αb-crystallin-based desmin-related cardiomyopathy
-
Maloyan, A. et al. Exercise reverses preamyloid oligomer and prolongs survival in αB-crystallin-based desmin-related cardiomyopathy. Proc. Natl Acad. Sci. USA 104, 5995-6000 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 5995-6000
-
-
Maloyan, A.1
-
115
-
-
33645282296
-
Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy
-
Konhilas, J. P. et al. Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. Circ. Res. 98, 540-548 (2006).
-
(2006)
Circ. Res
, vol.98
, pp. 540-548
-
-
Konhilas, J.P.1
-
116
-
-
34249279050
-
MicroRNA-133 controls cardiac hypertrophy
-
Care, A. et al. MicroRNA-133 controls cardiac hypertrophy. Nature Med. 13, 613-618 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 613-618
-
-
Care, A.1
-
117
-
-
84856078602
-
Exercise training prevents the microvascular rarefaction in hypertension balancing angiogenic and apoptotic factors: Role of microRNAs-16,-21, and-126
-
Fernandes, T. et al. Exercise training prevents the microvascular rarefaction in hypertension balancing angiogenic and apoptotic factors: role of microRNAs-16,-21, and-126. Hypertension 59, 513-520 (2012).
-
(2012)
Hypertension
, vol.59
, pp. 513-520
-
-
Fernandes, T.1
-
118
-
-
80052557916
-
MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes
-
Porrello, E. R. et al. MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ. Res. 109, 670-679 (2011).
-
(2011)
Circ. Res
, vol.109
, pp. 670-679
-
-
Porrello, E.R.1
-
119
-
-
34247589595
-
Control of stress-dependent cardiac growth and gene expression by a microRNA
-
van Rooij, E. et al. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575-579 (2007).
-
(2007)
Science
, vol.316
, pp. 575-579
-
-
Van Rooij, E.1
-
120
-
-
70349202176
-
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
-
Callis, T. E. et al. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J. Clin. Invest. 119, 2772-2786 (2009).
-
(2009)
J. Clin. Invest
, vol.119
, pp. 2772-2786
-
-
Callis, T.E.1
-
121
-
-
79251581576
-
MicroRNA-27a regulates β cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor β1 in neonatal rat ventricular myocytes
-
Nishi, H. et al. MicroRNA-27a regulates β cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor β1 in neonatal rat ventricular myocytes. Mol. Cell. Biol. 31, 744-755 (2011).
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 744-755
-
-
Nishi, H.1
|