Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis

Journal of Biological Chemistry

Volumn 289, Issue 26, 2014, Pages 18603-18613

  Landis, Justine ^a   Shaw, Leslie M ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; CHEMICAL ACTIVATION; GLUCOSE; INSULIN; PATHOLOGY; PROTEINS; SIGNALING; TUMORS;

CELL SURFACE RECEPTORS; GLYCOGEN SYNTHASE KINASE-3; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTORS; LIGAND STIMULATION; PHOSPHATIDYLINOSITOL 3-KINASE; SIGNALING PATHWAYS; TYROSINE RESIDUES;

SUBSTRATES;

GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LACTIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; TYROSINE;

ANIMAL CELL; ARTICLE; BREAST TUMOR; CELL METABOLISM; CONTROLLED STUDY; GLUCOSE TRANSPORT; GLYCOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEIN; AKT; BREAST CANCER; GLUT1; GLYCOGEN SYNTHASE KINASE 3 (GSK-3); GLYCOLYSIS; INSULIN-LIKE GROWTH FACTOR (IGF); IRS-2; PI3K;

AMINO ACID MOTIFS; ANIMALS; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; DOWN-REGULATION; FEMALE; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOLYSIS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; LACTIC ACID; MICE; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84903535463     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.564070     Document Type: Article

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