The antioxidant edaravone prevents cardiac dysfunction by suppressing oxidative stress in type 1 diabetic rats and in high-glucose-induced injured H9c2 cardiomyoblasts

Canadian Journal of Physiology and Pharmacology

Volumn 94, Issue 9, 2016, Pages 996-1006

  Ji, Lei ^a,b   Liu, Yingying ^c   Zhang, Ying ^a   Chang, Wenguang ^d   Gong, Junli ^b   Wei, Shengnan ^d   Li, Xudong ^b   Qin, Ling ^a  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b Changchun Central Hospital   (China)

^c CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^d JILIN UNIVERSITY   (China)

Author keywords

Apoptosis; Edaravone; Oxidative stress; Type 1 diabetes

Indexed keywords

CASPASE 3; GLUCOSE; NORPHENAZONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; GLUCOSE BLOOD LEVEL; INSULIN; NFE2L2 PROTEIN, RAT; PHENAZONE; PHENYLMETHYLPYRAZOLONE; PPARGC1A PROTEIN, RAT; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CARDIAC MYOBLAST; CELL DEATH; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; HEART DISEASE; HEART FUNCTION; HEART INJURY; INCUBATION TIME; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE CELL; CELL CULTURE TECHNIQUE; DIABETIC CARDIOMYOPATHIES; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENE SILENCING; GLUCOSE BLOOD LEVEL; HYPERTROPHY; METABOLISM; PATHOLOGY;

ANIMALS; ANTIOXIDANTS; ANTIPYRINE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BLOOD GLUCOSE; CASPASE 3; CELL CULTURE TECHNIQUES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; FREE RADICAL SCAVENGERS; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HYPERTROPHY; INSULIN; MALE; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIRTUIN 1; SUPEROXIDE DISMUTASE;

EID: 84985905161     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2015-0587     Document Type: Article

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