Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells

British Journal of Pharmacology

Volumn 173, Issue 6, 2016, Pages 1018-1032

  Horinouchi, Takahiro ^a   Hoshi, Akimasa ^a   Harada, Takuya ^a   Higa, Tsunaki ^a   Karki, Sarita ^a   Terada, Koji ^a   Higashi, Tsunehito ^a   Mai, Yosuke ^a   Nepal, Prabha ^a   Mazaki, Yuichi ^a   Miwa, Soichi ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DEOXYGLUCOSE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE; MESSENGER RNA; MYOD PROTEIN; MYOGENIN; OMIPALISIB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; RAB PROTEIN; RETROVIRUS VECTOR; RNA 18S; SERINE; SMALL INTERFERING RNA; THREONINE; ADRBK1 PROTEIN, RAT; GLUCOSE; MYOG PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; EXPRESSION VECTOR; GENE TRANSFER; GLUCOSE TRANSPORT; HEART MUSCLE CONTRACTILE FORCE; IMMUNOPRECIPITATION; INSULIN RESISTANCE; MUSCLE CELL; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; VASOCONSTRICTION; WESTERN BLOTTING; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; MYOBLAST; PHOSPHORYLATION; SKELETAL MUSCLE CELL;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; ENDOTHELIN-1; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GLUCOSE; INSULIN; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; MYOBLASTS; MYOD PROTEIN; MYOGENIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, MESSENGER; RNA, RIBOSOMAL, 18S;

EID: 84960087595     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13406     Document Type: Article

References (51)

1. Alexander SPH, Davenport AP, Kelly E, Marrion N, Peters JA, Benson HE, et al,. (2015a). The Concise Guide to PHARMACOLOGY 2015/16: G Protein-Coupled Receptors. Br J Pharmacol 172: 5744-5869.
2. Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, et al,. (2015b). The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol 172: 5979-6023.
3. Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, et al,. (2015c). The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol 172: 6024-6109.
4. Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, et al,. (2015d). The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol 172: 6110-6202.
5. Alexander SP, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164: S1-S324.
6. Bentzinger CF, Wang YX, Rudnicki MA, (2012). Building muscle: molecular regulation of myogenesis. Cold Spring Harb Perspect Biol 4: ID a008342.
7. Bradford MM, (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
8. Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SPH, Giembycz MA, et al,. (2015). Experimental design and analysis and their reporting: new guidance for publication in BJP. Br J Pharmacol 172: 3461-3471.
9. DeFronzo RA, (1988). Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37: 667-687.
10. Evron T, Daigle TL, Caron MG, (2012). GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol Sci 33: 154-164.
11. Ferri C, Bellini C, Desideri G, Di Francesco L, Baldoncini R, Santucci A, et al,. (1995). Plasma endothelin-1 levels in obese hypertensive and normotensive men. Diabetes 44: 431-436.
12. Gomes AR, Soares AG, Peviani S, Nascimento RB, Moriscot AS, Salvini TF, (2006). The effect of 30 minutes of passive stretch of the rat soleus muscle on the myogenic differentiation, myostatin, and atrogin-1 gene expressions. Arch Phys Med Rehabil 87: 241-246.
13. Harada T, Horinouchi T, Higa T, Hoshi A, Higashi T, Terada K, et al,. (2014). Endothelin-1 activates extracellular signal-regulated kinases 1/2 via transactivation of platelet-derived growth factor receptor in rat L6 myoblasts. Life Sci 104: 24-31.
14. Horinouchi T, Higashi T, Higa T, Terada K, Mai Y, Aoyagi H, et al,. (2012). Different binding property of STIM1 and its novel splice variant STIM1L to Orai1, TRPC3, and TRPC6 channels. Biochem Biophys Res Commun 428: 252-258.
15. Horinouchi T, Terada K, Higashi T, Miwa S, (2013). Endothelin receptor signaling: new insight into its regulatory mechanisms. J Pharmacol Sci 123: 85-101.
16. Imamura T, Vollenweider P, Egawa K, Clodi M, Ishibashi K, Nakashima N, et al,. (1999). G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3 T3-L1 adipocytes. Mol Cell Biol 19: 6765-6774.
17. Jin P, Sejersen T, Ringertz NR, (1991). Recombinant platelet-derived growth factor-BB stimulates growth and inhibits differentiation of rat L6 myoblasts. J Biol Chem 266: 1245-1249.
18. Kamikawa Y, Ikeda S, Harada K, Ohwatashi A, Yoshida A, (2013). Passive repetitive stretching for a short duration within a week increases myogenic regulatory factors and myosin heavy chain mRNA in rats' skeletal muscles. Scientific World Journal 2013: ID 493656.
19. Kim I, Yang D, Tang X, Carroll JL, (2011). Reference gene validation for qPCR in rat carotid body during postnatal development. BMC Res Notes 4: ID 440.
20. Knight SD, Adams ND, Burgess JL, Chaudhari AM, Darcy MG, Donatelli CA, et al,. (2010). Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med Chem Lett 1: 39-43.
21. βγ-mediated signaling. J Biol Chem 269: 6193-6197.
22. Kurose H, Nishida M, Nagao T, (1999). βγ subunit of heterotrimeric G protein as a new target molecule for drug development. Folia Pharmacol Jpn 114: 75-80.
23. Laplante M, Sabatini DM, (2012). mTOR signaling in growth control and disease. Cell 149: 274-293.
24. Lerman A, Edwards BS, Hallett JW, Heublein DM, Sandberg SM, Burnett JCJ, (1991). Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 325: 997-1001.
25. Leto D, Saltiel AR, (2012). Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol 13: 383-396.
26. Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC, (2005). A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 11: 952-958.
27. Lteif A, Vaishnava P, Baron AD, Mather KJ, (2007). Endothelin limits insulin action in obese/insulin-resistant humans. Diabetes 56: 728-734.
28. Mitsumoto Y, Burdett E, Grant A, Klip A, (1991). Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells. Biochem Biophys Res Commun 175: 652-659.
29. Mitsumoto Y, Klip A, (1992). Development regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells. J Biol Chem 267: 4957-4962.
30. Nevzorova J, Bengtsson T, Evans BA, Summers RJ, (2002). Characterization of the β-adrenoceptor subtype involved in mediation of glucose transport in L6 cells. Br J Pharmacol 137: 9-18.
31. o are target proteins of reactive oxygen species. Nature 408: 492-495.
32. Öberg A, Dehvari N, Bengtsson T, (2011). β-Adrenergic inhibition of contractility in L6 skeletal muscle cells. PLoS One 6: e22304.
33. Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L, (2002). Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5: 566-572.
34. Ottosson-Seeberger A, Lundberg JM, Alvestrand A, Ahlborg G, (1997). Exogenous endothelin-1 causes peripheral insulin resistance in healthy humans. Acta Physiol Scand 161: 211-220.
35. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SPH, Buneman OP, et al,., NC-IUPHAR (2014) The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucl. Acids Res. 42 (Database Issue): D1098-1106.
36. Pernow J, Shemyakin A, Böhm F, (2012). New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus. Life Sci 91: 507-516.
37. Rodríguez-Pascual F, Busnadiego O, Lagares D, Lamas S, (2011). Role of endothelin in the cardiovascular system. Pharmacol Res 63: 463-472.
38. Rubin LJ, (2012). Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. Life Sci 91: 517-521.
39. Ruest LB, Marcotte R, Wang E, (2002). Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. J Biol Chem 277: 5418-5425.
40. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM, (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
41. Schalin-Jäntti C, Yki-Järvinen H, Koranyi L, Bourey R, Lindström J, Nikula-Ijäs P, et al,. (1994). Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives. Diabetologia 37: 401-407.
42. Shemyakin A, Salehzadeh F, Esteves Duque-Guimaraes D, Böhm F, Rullman E, Gustafsson T, et al,. (2011). Endothelin-1 reduces glucose uptake in human skeletal muscle in vivo and in vitro. Diabetes 60: 2061-2067.
43. Shepherd PR, Nave BT, Rincon J, Haigh RJ, Foulstone E, Proud C, et al,. (1997). Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism. Diabetologia 40: 1172-1177.
44. 3. Am J Physiol Endocrinol Metab 293: E536-E544.
45. Takahashi K, Ghatei MA, Lam HC, O'Halloran DJ, Bloom SR, (1990). Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia 33: 306-310.
46. Touyz RM, Schiffrin EL, (2003). Role of endothelin in human hypertension. Can J Physiol Pharmacol 81: 533-541.
47. Tsakiridis T, McDowell HE, Walker T, Downes CP, Hundal HS, Vranic M, et al,. (1995). Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells. Endocrinology 136: 4315-4322.
48. Usui I, Imamura T, Babendure JL, Satoh H, Lu JC, Hupfeld CJ, et al,. (2005). G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Gαq/11 and insulin receptor substrate-1 pathways in 3 T3-L1 adipocytes. Mol Endocrinol 19: 2760-2768.
49. Usui I, Imamura T, Huang J, Satoh H, Olefsky JM, (2003). Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3 T3-L1 adipocytes. J Biol Chem 278: 13765-13774.
50. Usui I, Imamura T, Satoh H, Huang J, Babendure JL, Hupfeld CJ, et al,. (2004). GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. EMBO J 23: 2821-2829.
51. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al,. (1988). A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415.