Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes

Cellular Signalling

Volumn 27, Issue 3, 2015, Pages 707-715

  Fu, Qin ^a,b   Xu, Bing ^b   Parikh, Dippal ^b   Cervantes, David ^c   Xiang, Yang K ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Adrenergic receptor; CAMP; Cardiac contractility; GRK2; Insulin receptor; Internalization

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR KINASE 2; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; ADRBK1 PROTEIN, MOUSE; BETA 1 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; INSULIN RECEPTOR SUBSTRATE; IRS2 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ARTICLE; ATTENUATION; CELL MIGRATION; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; HEART MUSCLE CELL; INTERNALIZATION; MALE; MOUSE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CARDIAC MUSCLE CELL; CELL LINE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUSCLE CONTRACTION; PHOSPHORYLATION; PROTEIN TRANSPORT;

ANIMALS; CELL LINE; COLFORSIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-PROTEIN-COUPLED RECEPTOR KINASE 2; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 84922594993     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.11.018     Document Type: Article

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